Konjenital hipotiroidi, yenidoğan döneminde uzamış sarılığın önde gelen nedenlerinden biridir ve önlenebilir zeka geriliğinin en sık nedenidir. Bu kesitsel çalışmada Eylül 80-Mart 2005 tarihleri arasında Gaziantep Çocuk Hastanesi'ne başvuran uzamış sarılığı olan 2006 ayaktan hastada konjenital hipotiroidi sıklığı araştırıldı. Plazma total bilirubin düzeyi 5 mg/dL'nin üzerinde olan hastalar çalışmaya dahil edildi (12.3±4.6 mg/dL), direkt hiperbilirubinemisi olan hastalar çalışmaya dahil edilmedi. Hastalar 15-45 gün arasındaydı. Konjenital hipotiroidi tanı kriterleri serum TSH düzeyi 20 mU/L'nin üzerinde idi. Konjenital hipotiroidi tanısı uzamış sarılığı olan (...) 3 hastanın 4'inde (%5.6) konuldu. TSH düzeyi dört hastada 3 mU/L'nin, bir hastada ise 80 mU/L'nin üzerindeydi. Verilerimiz, konjenital hipotiroidizmin uzamış sarılığı olan yenidoğanların önemli bir bölümünü oluşturduğuna işaret etmektedir. (shrink)

Though researchers working on congenital aphantasia (henceforth “aphantasia”) agree that this condition involves an impairment in the ability to voluntarily generate visual imagery, disagreement looms large as to which other impairments are exhibited by aphantasic subjects. This article offers the first extensive review of studies on aphantasia, and proposes that aphantasic subjects exhibit a cluster of impairments. It puts forward a novel cognitive theory of aphantasia, building on the constructive episodic simulation hypothesis of memory and imagination. It argues that (...) aphantasia is best explained as a malfunction of processes in the episodic system, and is therefore an episodic system condition. (shrink)

The rapid development of artificial womb technologies means that we must consider if and when it is permissible to kill the human subject of ectogestation—recently termed a ‘gestateling’ by Elizabeth Chloe Romanis—prior to ‘birth’. We describe the act of deliberately killing the gestateling as gestaticide, and argue that there are good reasons to maintain that gestaticide is morally equivalent to infanticide, which we consider to be morally impermissible. First, we argue that gestaticide is harder to justify than abortion, primarily because (...) the gestateling is completely independent of its biological parents. Second, we argue that gestaticide is morally equivalent to infanticide. To demonstrate this, we explain that gestatelings are born in a straightforward sense, which entails that killing them is infanticide. However, to strengthen our overall claim, we also show that if gestatelings are not considered to have been born, killing them is still equivalent to killing neonates with congenital anomalies and disabilities, which again is infanticide. We conclude by considering how our discussion of gestaticide has implications for the permissibility of withdrawing life-sustaining treatment from gestatelings. (shrink)

Epistemic peer disagreement raises interesting questions, both in epistemology and in philosophy of science. When is it reasonable to defer to the opinion of others, and when should we hold fast to our original beliefs? What can we learn from the fact that an epistemic peer disagrees with us? A question that has received relatively little attention in these debates is the value of epistemic peer disagreement—can it help us to further epistemic goals, and, if so, how? We investigate this (...) through a recent case in paleoanthropology: the debate on the taxonomic status of Homo floresiensis remains unresolved, with some authors arguing the fossils represent a novel hominin species, and others claiming that they are Homo sapiens with congenital growth disorders. Our examination of this case in the recent history of science provides insights into the value of peer disagreement, indicating that it is especially valuable if one does not straightaway defer to a peer’s conclusions, but nevertheless remains open to a peer’s evidence and arguments. (shrink)

Modal epistemologists parse modal conditions on knowledge in terms of metaphysical possibilities or ways the world might have been. This is problematic. Understanding modal conditions on knowledge this way has made modal epistemology, as currently worked out, unable to account for epistemic luck in the case of necessary truths, and unable to characterise widely discussed issues such as the problem of religious diversity and the perceived epistemological problem with knowledge of abstract objects. Moreover, there is reason to think that this (...) is a congenital defect of orthodox modal epistemology. This way of characterising modal epistemology is however optional. It is shown that one can non-circularly characterise modal conditions on knowledge in terms of epistemic possibilities, or ways the world might be for the target agent. Characterising the anti-luck condition in terms of epistemic possibilities removes the impediment to understanding epistemic luck in the case of necessary truths and opens the door to using these conditions to shed new light on some longstanding epistemological problems. (shrink)

The paradigm of referent tracking is based on a realist presupposition which rejects so-called negative entities (congenital absent nipple, and the like) as spurious. How, then, can a referent tracking-based Electronic Health Record deal with what are standardly called ‘negative findings’? To answer this question we carried out an analysis of some 748 sentences drawn from patient charts and containing some form of negation. Our analysis shows that to deal with these sentences we need to introduce a new ontological (...) relationship between a particular and a universal, which holds when no instance of the universal has a specific qualified ontological relation with the particular. This relation is found to be able to accommodate nearly all occurrences of negative findings in the examined sample, in ways which involve no reference to negative entities. (shrink)

Social cognition researchers have become increasingly interested in the ways that behavioral, physiological, and neural coupling facilitate social interaction and interpersonal understanding. We distinguish two ways of conceptualizing the role of such coupling processes in social cognition: strong and moderate interactionism. According to strong interactionism (SI), low-level coupling processes are alternatives to higher-level individual cognitive processes; the former at least sometimes render the latter superfluous. Moderate interactionism (MI) on the other hand, is an integrative approach. Its guiding assumption is that (...) higher-level cognitive processes are likely to have been shaped by the need to coordinate, modulate, and extract information from low-level coupling processes. In this paper, we present a case study on Möbius Syndrome (MS) in order to contrast SI and MI. We show how MS—a form of congenital bilateral facial paralysis—can be a fruitful source of insight for research exploring the relation between high-level cognition and low-level coupling. Lacking a capacity for facial expression, individuals with MS are deprived of a primary channel for gestural coupling. According to SI, they lack an essential enabling feature for social interaction and interpersonal understanding more generally and thus ought to exhibit severe deficits in these areas. We challenge SI’s prediction and show how MS cases offer compelling reasons for instead adopting MI’s pluralistic model of social interaction and interpersonal understanding. We conclude that investigations of coupling processes within social interaction should inform rather than marginalize or eliminate investigation of higher-level individual cognition. (shrink)

In the period of emergence of early modern science, ‘monsters’ or individuals with physical congenital anomalies were considered as rare events which required special explanations entailing assumptions about the laws of nature. This concern with monsters was shared by representatives of the new science and Late Scholastic authors of university textbooks. This paper will reconstruct the main theses of the treatment of monsters in Late Scholastic textbooks, by focusing on the question as to how their accounts conceived nature’s regularity (...) and teleology. It shows that they developed a naturalistic teratology in which, in contrast to the naturalistic explanations usually offered by the new science, finality was at central stage. This general point does not impede our noticing that some authors were closer to the views emerging in the Scientific Revolution insofar as they conceived nature as relatively autonomous from God and gave a relevant place to efficient secondary causation. In this connection, this paper suggests that the concept of the laws of nature developed by the new science –as exception-less regularities—transferred to nature’s regularity the ‘strong’ character that Late Scholasticism attributed to finality and that the decline of the Late Scholastic view of finality played as an important concomitant factor permitting the transformation of the concept of laws of nature. (shrink)

It has a long history for the exploration of the origin and essence of human consciousness with different definitions and explanations in various fields such as philosophy, medicine, sociology, biology, and psychology. However, all of them had not been recognized so far. The main reason is that the complexity of consciousness leads to the inability of various fields to understand its essence fully, reasonably, and comprehensively, and there are still significant differences for it, and which have become an eternal mystery. (...) So, it is necessary to delve deeper into it. Here we show that this article concludes that the origin of consciousness comes from natural matter, the essence of consciousness is material information, the ability of consciousness is the degree to which the complexity and orderliness of material information are utilized, and consciousness has the attributes of congenital, materiality, systematicness, complexity, dynamics, difference, and selfness according to the analysis, summary and induction of knowledge from various disciplines. (shrink)

The argument for vegetarianism from overlapping species goes like this. Every individual who is the subject of a life has a right to life. Some humans—e.g., the severely congenitally cognitively limited—lack language, rationality, autonomy, and self-consciousness, and yet they are subjects of a life. Severely congenitally cognitively limited humans have a right to life. Some animals—e.g., all mammals—lack language, rationality, autonomy, and self-consciousness, and yet they are subjects of a life. We ought to treat like cases alike. The cases of (...) some humans are like the cases of some animals. Therefore, some animals have a right to life. -/- The argument seems not to have moved many people to change their diets. The reason, I suggest, is not because the argument is unsound but because our ability to change our dietary practices is difficult and we lack the imaginative resources to see the world from a nonhuman perspective. -/- I suggest that creative artists are of great value here, and I provide an example by referring to the work of the American novelist, Cormac McCarthy. (shrink)

How does visual imagination differ from visual perceptual experience? And how should we describe experiences of visual imagery? Moreover how can people who have visual imagery convey what it is like to have it to those who have never had it – congenital aphantisics? This paper addresses these questions using examples of illusions and other perceptual phenomena to hone in on the answers.

The aim of this chapter is to shed new light on the question of what newly sighted subjects are capable of seeing on the basis of previous experience with mind- independent, external objects and their properties through touch alone. This question is also known as "Molyneux’s question." Much of the empirically driven debate surrounding this question has been centered on the nature of the representational content of the subjects' visual experiences. It has generally been assumed that the meaning of "seeing" (...) deployed in these disputes is more or less clear and unproblematic, and therefore requires no analysis or clarification. In this chapter, we wish to challenge this assumption. We argue that getting clear on the meaning of "seeing" is the only feasible way to determine whether the empirical attempts to answer Molyneux’s question accurately capture what newly sighted subjects are in fact capable of seeing. Specifically, we show that the dominant interpretations of the empirical results from a recent study (Held et al., 2011) fail to take into account that seeing can be not only purely visual but also epistemic in that it requires background knowledge (such as what an object with a particular viewpoint-independent shape looks like from a particular perspective). (shrink)

In this paper it is shown that Heyting and Co-Heyting mereological systems provide a convenient conceptual framework for spatial reasoning, in which spatial concepts such as connectedness, interior parts, (exterior) contact, and boundary can be defined in a natural and intuitively appealing way. This fact refutes the wide-spread contention that mereology cannot deal with the more advanced aspects of spatial reasoning and therefore has to be enhanced by further non-mereological concepts to overcome its congenital limitations. The allegedly unmereological concept (...) of boundary is treated in detail and shown to be essentially affected by mereological considerations. More precisely, the concept of boundary turns out to be realizable in a variety of different mereologically grounded versions. In particular, every part K of a Heyting algebra H gives rise to a well-behaved K-relative boundary operator. (shrink)

In this paper I argue that the idiosyncrasy of linguistic competence fosters semantic conceptions in which meanings are taken for granted, such as the one that Quine calls ‘uncritical semantics’ or ‘the myth of the museum’. This is due to the degree of automaticity in the use of language which is needed for fluent conversation. Indeed, fluent conversation requires that we speakers instinctively associate each word or sentence with its meaning (or linguistic use), and instinctively resort to the conceptual repertoire (...) of our language, without calling into question that the meaning of a particular word, or the conceptual repertoire of our language, could have been different than they are. This habit of taking meanings for granted, inherent to our linguistic ability, sometimes interferes with our semantic research, hampering it. In order to illustrate this problem, I pinpoint four places in Quine’s work where, despite his acknowledged analytical rigour, and despite his congenital aversion to the habit of taking meanings for granted, he himself appears to slip into this habit, inadvertently. (shrink)

Eastern philosophy and western science have convergent and divergent viewpoints for their explanation of consciousness. Convergence is found for the practice of meditation allowing besides a time dependent consciousness, the experience of a timeless consciousness and its beneficial effect on psychological wellbeing and medical improvements, which are confirmed by multiple scientific publications. Theories of quantum mechanics with non-locality and timelessness also show astonishing correlation to eastern philosophy, such as the theory of Penrose-Hameroff (ORC-OR), which explains consciousness by reduction of quantum (...) superposition in the brain. Divergence appears in the interpretation of the subjective experience of timeless consciousness. In eastern philosophy, meditation at a higher level of awareness allows the personal experience of timeless and non-dual consciousness, considered as an empirical proof for the existence of pure consciousness or spirituality existing before the material world and creating it by design. Western science acknowledges the subjective, non-dual experience, and its multiple beneficial effects, however, the interpretation of spirituality designing the material universe is in disagreement with the Darwinian Theory of mutation and selection. A design should create an ideal universe without the injustice of 3% congenital birth defects and later genetic health problems. The western viewpoint of selection is more adapted to explain congenital errors. The gap between subjectivity and objectivity, the mind-body problem, is in eastern philosophy reduced to the dominance of subjectivity over objectivity, whereas western science attributes equal values to both. Nevertheless, there remains an astonishing complementarity between eastern and western practices. (shrink)

How "red", "green" were defined? Through analyzing how two children with congenitally inverted color sensations corresponding to red flags and green grass accept their grand mothers’ teaching about colors, the paper get opposite conclusions against logical empiricism. The “red” and “green” and other names of properties of objects were defined by objective physical properties (or together with behavior, such as in defining “beauty”), instead our sensations. So language directly points to things in themselves passing through sensations and presentative world. It (...) is not that things in themselves are unknowable, but that sensations and presentative world cannot be exactly described by daily language. (shrink)

This paper introduces three new criteria that a theory of personal identity ought to satisfy: (1) material holism, (2) narrative unity, and (3) narrative integrity. Material holism guards against the undesirable consequence of positing the person as part and existentially distinct from the organismal whole, of which it is dependent and interconnected. Narrative unity ensures that continuity between the beginning, middle, and end of a human life is sufficiently accounted for. Narrative integrity secures fidelity and congruence between each part and (...) the whole, the whole to each part. Jeff McMahan’s Embodied Mind Account (EM) fails to satisfy each of these. On McMahan’s account, human persons and human organisms are distinct entities, human persons come into existence after its human organism, and human persons may go out of existence before their human organism. Moreover, fetuses, infants, the congenitally severely cognitively impaired, those with severe dementia, and the comatose are non-persons. A theory of personal identity that incorporates holism and narrative can provide a better explanation of human existence, life and death, and the identity paradox of dicephalic twins. If accepted, EM must either be rejected or ameliorated, and the new criteria ought to be incorporated in contemporary research of personal identity. (shrink)

Myocardial disarray is the screening tool for HCM (hypertrophy cardiomyopathy). It is also found in hypertension, congenital heart disease, corpulmonale, etc. Many patients died from heart failure due to myocardial disarray. The risk of premature death may be determined by the degree of myocyte disarray. This article reviews the anatomical explanation of myocardial disarray. It also discusses the pathogenesis of the myocardial disorganization that causes heart failure. How to measure myocardial disarray has also been assessed. Therefore, early detection of (...) myocardial disarray is advised to prevent heart failure. (shrink)

In the last few decades psychologists have gained a clearer picture of the notion of happiness and a more sophisticated account of its explanation. Their research has serious consequences for any ethic based on the maximization of happiness, especially John Stuart Mill’s classical eudaimonistic utilitarianism. In the most general terms, the research indicates that a congenital basis for homeostatic levels of happiness in populations, the hedonic treadmill effect, and other personality factors, contribute to maintain a satisfactory level of happiness (...) over the long run for a large percentage of any population, and relatively independently of the circumstances of the population. Consequently, although there are certainly ethical reasons to address the conditions of persons and populations, it is of marginal value to base such decisions on improvements in their levels of happiness. The happiness of others is not a sensible criterion for ethical decision-making. (shrink)

This article discusses an anomaly in the English law of reproductive liability: that is, an inconsistency between the law’s approach to wrongful life claims and its approach to cases of negligent selection of gametes or embryos in infertility treatments (the selection cases). The article begins with an account of the legal position, which brings into view the relevant inconsistency: while the law treats wrongful life claims as non- actionable, it recognises a cause of action in the selection cases, although the (...) selection cases bear a relevant resemblance to wrongful life claims. The article then considers arguments that may be invoked in an attempt to reconcile the above two strands of the law. Three of these counterarguments consist in attempts to distinguish the selection cases from wrongful life claims. It is argued that these attempts fail to reveal a valid basis for treating these situations differently. A fourth possible counterargument levels against the present analysis a charge of reductio ad absurdum. It is shown that this argument suffers from a fundamental flaw caused by confusion between different senses of the term “identity”. Finally, the article discusses possible changes to the legal position that could rectify the problem. It argues that one of these changes, which focuses on legal redress for violation of personal autonomy, is particularly apt to resolve the problem at hand, but also highlights the need for further inquiry into the broader implications of introducing this form of redress into the law of torts. (shrink)

Given that they are chance events, there can be no scientific demonstration or knowledge of monsters. There are still, however, many recognizable elements of scientific explanation in Aristotle's Generation of Animals Book IV chapter 4. What happens in cases of monsters and deformities occurs in the process of generation, and there is much that we can know scientifically about this process—working from the animal’s essential attributes outward to factors that influence these processes. In particular, we find Aristotle looking for and (...) investigating whether “for the most part” correlations are causally relevant and linked to essence. Even though the birth of monsters is scientifically inexplicable, the features of animals that tend to produce them can be known about. I will explain how it is that producing more than one offspring per birth is a knowable feature of a kind. This feature, along with others, can then give us a much better grasp on what happens in particular instances of monstrous birth. (shrink)