The Protein Ontology (PRO; http://purl.obolibrary.org/obo/pr) formally defines and describes taxon-specific and taxon-neutral protein-related entities in three major areas: proteins related by evolution; proteins produced from a given gene; and protein-containing complexes. PRO thus serves as a tool for referencing protein entities at any level of specificity. To enhance this ability, and to facilitate the comparison of such entities described in different resources, we developed a standardized representation of proteoforms using UniProtKB as a sequence reference and PSI-MOD as a post-translational modification (...) reference. We illustrate its use in facilitating an alignment between PRO and Reactome protein entities. We also address issues of scalability, describing our first steps into the use of text mining to identify protein-related entities, the large-scale import of proteoform information from expert curated resources, and our ability to dynamically generate PRO terms. Web views for individual terms are now more informative about closely-related terms, including for example an interactive multiple sequence alignment. Finally, we describe recent improvement in semantic utility, with PRO now represented in OWL and as a SPARQL endpoint. These developments will further support the anticipated growth of PRO and facilitate discoverability of and allow aggregation of data relating to protein entities. (shrink)

Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates to (...) UniProtKB in that PRO’s organism-specific classes of proteins encoded by a specific gene correspond to entities documented in UniProtKB entries. PRO relates to the GO in that PRO’s representations of organism-specific protein complexes are subclasses of the organism-agnostic protein complex terms in the GO Cellular Component Ontology. The past few years have seen growth and changes to the PRO, as well as new points of access to the data and new applications of PRO in immunology and proteomics. Here we describe some of these developments. (shrink)

Le Père Ignace Carbonnelle, l'un des principaux fondateurs de la Société scientifique de Bruxelles en 1875 et son secrétaire général depuis cette époque, décède inopinément en 1889 après une quin­zaine d'années durant lesquelles il fut «l'homme fort» de ladite Société. Aussitôt, la Revue des questions scienti­fiques annonce la triste nouvelle, promettant, pour un prochain numéro, une étude détaillée de sa vie et de son œuvre. Elle ne paraîtra jamais, de sorte que sa mort ne fut pas saluée avec l'ampleur qu'on (...) était en droit d'attendre. Et pour cause ! Au ter­me d'une enquête digne d'un roman policier, cette étude révèle que Rome, agacée par l'atomisme de Carbonnelle, profita de sa mort pour rappeler à l'ordre la Société en l'invitant à marcher dans les pas de l'Aquinate. En réponse à cette pressante invi­tation et par un excès de zèle non requis, la Société élut comme président le célèbre thomiste français Edmond Domet de Vor­ges, cependant que le mathématicien Paul Mansion s'attacha d'établir, à partir des publications de Pierre Duhem prônant un retour à une physique des qualités, que la Société se conformait bien, mais à sa manière, aux injonctions romaines. ––– Fr. Ignace Carbonnelle, who founded the Brussels Scientific Society in 1875 and was from this date onwards her Secretary General, passed away suddenly in 1889, after fifteen years during which he was the leading figure of the aforementioned Society. “La Revue des Question scientifique” announced the sad news but promised that their next publication would include a detailed article on the great man and his works. Sadly this article never appeared, meaning that the passing of Fr. Carbonnelle was not marked with the importance which we might have otherwise expected. For what reason, you may well ask? After a detailed investigation, worthy of Agatha Christie herself, it would appear that Rome had been rather alarmed by the “atomism” present in Fr. Carbonnelle's reflections, and had taken the opportunity of his death to invite the Scientific Society to opinions more in line with those of St Thomas. In response to this firmly worded invitation, and with overzealous spontaneity, the Society elected the celebrated French Thomiste Edmond Domet de Vorges as their new President. At the same time the mathematician Paul Mansion relied on the publications of Pierre Duhem, which advocated a stronger adhesion to a physics of an object's qualities, to establish that the Society was, in fact, well aligned with the desires of Rome. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users, accessible at: http://purl.obolibrary.org/obo/ncro.owl. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users, accessible at: http://purl.obolibrary.org/obo/ncro.owl. (shrink)

l. There is an antinomy in Hare's thought between Ought-Implies-Can and No-Indicatives-from-Imperatives. It cannot be resolved by drawing a distinction between implication and entailment. 2. Luther resolved this antinomy in the l6th century, but to understand his solution, we need to understand his problem. He thought the necessity of Divine foreknowledge removed contingency from human acts, thus making it impossible for sinners to do otherwise than sin. 3. Erasmus objected (on behalf of Free Will) that this violates Ought-Implies-Can which he (...) supported with Hare-style ordinary language arguments. 4. Luther a) pointed out the antinomy and b) resolved it by undermining the prescriptivist arguments for Ought-Implies-Can. 5. We can reinforce Luther's argument with an example due to David Lewis. 6. Whatever its merits as a moral principle, Ought-Implies-Can is not a logical truth and should not be included in deontic logics. Most deontic logics, and maybe the discipline itself, should therefore be abandoned. 7. Could it be that Ought-Conversationally-Implies-Can? Yes - in some contexts. But a) even if these contexts are central to the evolution of Ought, the implication is not built into the semantics of the word; b) nor is the parallel implication built into the semantics of orders; and c) in some cases Ought conversationally implies Can, only because Ought-Implies-Can is a background moral belief. d) Points a) and b) suggest a criticism of prescriptivism - that Oughts do not entail imperatives but that the relation is one of conversational implicature. 8. If Ought-Implies-Can is treated as a moral principle, Erasmus' argument for Free Will can be revived (given his Christian assumptions). But it does not 'prove' Pelagianism as Luther supposed. A semi-Pelagian alternative is available. (shrink)

Where Deleuze and Guattari introduce us to “lines of flight,” they transcode the mechanics of “flight” through “capture,” fomenting what is understood by many as Deleuze’s philosophical thesis: forging an analog relationship between univocity and difference via multiplicitious immanence. This is, of course, posed against Freud’s molar unities in their second chapter “One or Several Wolves.” Thus, if Heidegger is the philosopher par excellance of queries between hermeneutics and immanence (the philosopher of anti-immanence), it is Deleuze who asks “what is (...) the relationship between immanence and multiplicity?” While, for radical immanence qua Laruelle and post-Laruelleans, Deleuze is confounded with multiplicity (caught in an eternal Prometheun ἰσονομία (isonomia) where there is no victor), for Deleuze multiplicity and difference are two components that can fit together adeptly. Guided by the principle of univocity, Deleuze describes a world of pure multiplicity—all multiplicities are equally immanent within nature. As Whitehead spoke of “occasions,” Deleuze speaks of specific gatherings (of heterogeneous multiplicities), dubbed “assemblages,” that occasion themselves as blips – blips of singularity on an otherwise smooth plane. Following philosopher Levi R. Bryant's account of "dim media," I situate political lines of flight qua psychogeographies vis-a-vis urban topology. (shrink)

There are two motivations commonly ascribed to historical actors for taking up statistics: to reduce complicated data to a mean value (e.g., Quetelet), and to take account of diversity (e.g., Galton). Different motivations will, it is assumed, lead to different methodological decisions in the practice of the statistical sciences. Karl Pearson and W. F. R. Weldon are generally seen as following directly in Galton’s footsteps. I argue for two related theses in light of this standard interpretation, based on a reading (...) of several sources in which Weldon, independently of Pearson, reflects on his own motivations. First, while Pearson does approach statistics from this "Galtonian" perspective, he is, consistent with his positivist philosophy of science, utilizing statistics to simplify the highly variable data of biology. Weldon, on the other hand, is brought to statistics by a rich empiricism and a desire to preserve the diversity of biological data. Secondly, we have here a counterexample to the claim that divergence in motivation will lead to a corresponding separation in methodology. Pearson and Weldon, despite embracing biometry for different reasons, settled on precisely the same set of statistical tools for the investigation of evolution. (shrink)

Dr. B.R. Ambedkar is one of the names who advocated to change social order of the age-old tradition of suppression and humiliation. He was an intellectual, scholar, statesman and contributed greatly in the nation building. He led a number of movements to emancipate the downtrodden masses and to secure human rights to millions of depressed classes. He has left an indelible imprint through his immense contribution in framing the modern Constitution of free India. He stands as a symbol of struggle (...) for achieving the Social Justice. We can assign several roles to this great personality due to his life full dedication towards his mission of eradicating evils from Indian society. The social evils of Indian society, also neglected this great personality even in intellectual sphere too. The so-called intellectuals of India not honestly discussed his contribution to Indian intellectual heritage, rather what they discussed, also smells their biases towards a Dalit literate and underestimated his great personality. This paper will attempt to discuss important facts about life and a short description of the literature written by Dr. B.R. Ambedkar. This is followed by discussion his philosophy in the five major sections i.e. Feminism and women empowerment, philosophy of education, ideas on social justice and equality, philosophy of politics and economics and philosophy of religion. (shrink)

Values are an important part of human existence, his society and human relations. All social, economic, political, and religious problems are in one sense is reflection of this special abstraction of human knowledge. We are living in a globalized village and thinking much about values rather than practice of it. If we define religion and spirituality we can say that religion is a set of beliefs and rituals that claim to get a person in a right relationship with God, and (...) spirituality is a focus on spiritual things and the spiritual world instead of physical/earthly things. If we think rationally we can find the major evils related to religion exiting in present society are due to lack of proper understanding of religion and spirituality. If we really know our own religions and values associated with it, we can create a beautiful world, full or love and respect for each and every human being. The proper knowledge and practice of any religion’s values can make an integrated man. In the book, The Buddha and His Dhamma, Dr. Ambedkar elucidated the significance and importance of Dhamma in human life. The Dhamma maintained purity of life, which meant abstains from lustful, evil practices. The Dhamma is a perfection of life and giving up craving. Dhamma’s righteousness means right relation of man to man in all sphere of life. The basic idea underlying religion is to create an atmosphere for the spiritual development of the individual. He said that Knowing the proper ways and means is more important than knowing the ideal. The major objective of this paper is to the study the religious philosophy of Dr. B.R. Ambedkar and to study how he established that religious and spiritual values enables religious people in particular and humanity at large to solve contemporary problems. (shrink)

R. G. Collingwood’s 'The Principles of Art' argues that art is the expression of emotion. This dissertation offers a new interpretation of that philosophy, and argues that this interpretation is both hermeneutically and philosophically plausible. The offered interpretation differs from the received interpretation most significantly in treating the concept of ‘art’ as primarily scalarly rather than binarily realisable (this is introduced in ch. 1), and in understanding Collingwood’s use of the term ‘emotion’ more broadly (introduced in ch. 2). -/- After (...) the exposition of ch. 1, the remainder of that chapter and the subsequent three chapters are each centred around one sort of objection. In ch. 1, I consider the objection that Collingwood’s scalar understanding of ‘art’ is deviant and unhelpful. I respond by first observing that the understanding is not deviant, and second that it is more philosophically and artistically illuminating. In ch. 2, I consider the objection that Collingwood’s understanding of ‘emotion’ is so narrow that it fails to do justice to the fact that art can be philosophically potent. I respond that his understanding of ‘emotion’ is broad enough that this objection fails. In ch. 3, I consider the objection that Collingwood has no theoretical room for the prima facie plausible thought that some emotions are not worth expressing in art. In response, I reinterpret the points that appear to support this contention in a way that makes them both more plausible and more Collingwoodian. Finally, in ch. 4, I consider the objection that Collingwood does not have the theoretical room to do justice to the value of the delight we take in art. I respond by arguing that although he does not have this room to say that this delight is itself an artistic value, it does yet have an important place in his philosophy. (shrink)

Dr. B. R. Ambedkar is one of the most eminent intellectual figures of modern India. The present year is being celebrated as 125th Birth Anniversary of Dr. B. R. Ambedkar. Educationist and humanist from all over the world are celebrating 125th Birth Anniversary of Dr. B. R. Ambedkar by organizing various events and programmes. In this regard the Centre for Positive Philosophy and Interdiscipinary Studies (CPPIS) Pehowa (Kurukshetra) took an initiative to be a part of this mega event by organizing (...) an national level esssay competition for students, publication of books, posters and research journals on Dr. B.R. Ambedkar. Dr. B.R. Ambedkar’s ideas, writings and outlook could well be characterized as belonging to that trend of thought called Social Humanism. He developed a socio-ethical philosophy and steadfastly stood for human dignity and freedom, socio-economic justice, material prosperity and spiritual discipline. He showed the enlightening path for Indian society via his ideals of freedom, equality and fraternity and made India a democratic country. The complete works of Dr. B.R. Ambedkar published by the Governemtn of Maharastra and it has taken about 25 years to complete this initiative in 21 Volumes with the name, “Dr. Babasaheb Ambedkar: Writing and Speeches” and covers 14000 pages. In the words of Trilochan Sing, “Above all, Dr. Ambedkar is a philosopher. Those who read his books cannot be failed to be impressed with steadffastness with which he pursues truth; and only those who have dispassionately read his books can frame true estimate of the greatness of the man”. These 21 Volumes includes books published by Dr. B.R. Ambedkar himself and unpublished writings and speaches too. The present volume entitled “Dr. B.R. Ambedkar: The Maker of Modern India” contains 12 research papers on the different aspects of philosophy of Dr. B.R. Ambedkar written by academicians from different branches of knowledge. You can find a variety of dialogues and concen about the theme of the book here. We are not defending this book as a highly an intellectual work but a smaller step to know the various aspects of this great personality and is a start to study his vast wisdom. You suggestions and comments are welcome to its first hand review version. (shrink)

To follow the legacy of Dr. B.R. Ambedkar, a RUSA Sponsored One-Day Facutly Development Programme on “Dr. B.R. Ambedkar, Indian Constitution and Indian Society” organised by the Department of Philosophy and P.G. Department of Public Administation held on 20th January, 2016 was a creative and fruitful effort to bring together the scholars and academicians from several disciplines to participate in the deliberations related to the conceptual understanding and insights of the philosophy of Dr. B.R. Ambedkar.

I thank Professor Otteson for his review of Escape from Leviathan (EFL). His exposition of what I wrote is relatively accurate. I shall here do my best to correct any misunderstandings and reply to his welcome criticisms, ignoring our various points of agreement and his generous praise.

Originally published in 1991, The Laboratory of the Mind: Thought Experiments in the Natural Sciences, is the first monograph to identify and address some of the many interesting questions that pertain to thought experiments. While the putative aim of the book is to explore the nature of thought experimental evidence, it has another important purpose which concerns the crucial role thought experiments play in Brown’s Platonic master argument.In that argument, Brown argues against naturalism and empiricism (Brown 2012), for mathematical Platonism (...) (Brown 2008), and from the Platonist-friendly, abstract universals posited by the Dretske-Tooley-Armstrong (DTA) account of the laws of nature to a more general, physical Platonism. The Laboratory of the Mind is where he takes this final step. (shrink)

XENOLOGY AND XENOTOPOGRAPHY OF BERNHARD WALDENFELS The paper strives to adapt Bernhard Waldenfels’ xenology and so called ‘xenotopography’ for the philosophico-literary studies in fantastic world-building with a special concern of the ‘portal-quest’ model of fantasy and SF. Following Waldenfel’s remarks on the nature of post- Husserlian diastasis of our world [Heimwelt] and otherworld [Fremdwelt] and acknowledging the consequences of allocating one’s attitude towards the otherness in the symbolical borderland [‘sphere of intermonde’] in between, it is examined whether such a model (...) can occur in the fantastic literature and what may be the consequence of xenotopographic reconsideration of its basic ontological premises. Additionally, the article offers an original xenotopograpfic model of worldbuilding which addresses three carefully chosen case studies of fantastic worlds from Orson Scott Card’s Ender’s Game tetralogy, Neil Gaiman’s Stardust and George R. R. Martin’s The Song of Ice and Fire. In the end, it is suggested that hitherto presented xenotopography gravely inspired a postmodern shift in the genres of fantasy and SF which results in more ethically conscious representations of the otherness and even more concise and alien comprehensive world-building. (shrink)

La característica central del pensamiento filosófico del siglo XX (si más no, de la llamada a día de hoy 'filosofía analítica') ha sido el interés por el estudio del lenguaje. El lenguaje religioso no ha sido una excepción a este interés. Uno de los ejemplos más tempranos de esta preocupación por el estudio del lenguaje religioso es el análisis propuesto por R. B. Braithwaite en su "An Empiricist's View of the Nature of Religious Belief" (1955). Dicho muy brevemente, la idea (...) básica de Braithwaite es que el lenguaje religioso no describe el mundo: aquellos que realizan una afirmación de índole religiosa no están aceptando la verdad de una proposición sino que están simplemente expresando su compromiso con un determinado código de conducta. Es por ello, dice Braithwaite, que adoptar una creencia religiosa no consiste en aceptar que el mundo se corresponde con una descripción de hechos determinada, sino en comprometerse a actuar de acuerdo con un código de conducta. El objetivo de este artículo es ofrecer un análisis crítico de la propuesta de Braithwaite. (shrink)

Throughout Peirce’s writing, we witness his developing vision of a machine that scientists will eventually be able to create. Nadin (2010) raised the question:Why do computer scientists continue to ignore Peirce’s sign theory? A review of the literature on Peirce’s theory and the semiotics machine reveals that many authors discussed the machine;however, they donot differentiate between a physical computer machine and its software. This paper discusses the problematic issues involved in converting Peirce’s theory into a programming language, machine and software (...) application. We demonstrate this challenge by introducing Peirce’s sign theory as a software application that runs under an open-source R environment. (shrink)

Carl R. Rogers, the founder of client-centered therapy, contributed to the development of self-reliant learning in education. He applied such concepts of client-centered therapy as realness, prizing, acceptance, trust, and empathy to educational area, and called attention the importance of the authentic relationship between teacher and student with such books as Freedom to Learn, Becoming A Person, and A Way of Being. Besides, he also focused on teachers‟ attitudes in classrooms in his works. His views still continue to influence the (...) practices in both contemporary psychotherapy and education. The current study aims to introduce Rogers‟ views on teachers‟ attitudes facilitating students‟ learning, to discuss the views in the light of existentialist approaches and thus to make contributions to the development of educational environments. (shrink)

Many find it plausible that for a given beneficiary, Y, benefactor, R, and action, ϕ, Y’s being grateful to R for ϕ-ing implies Y’s being grateful that R ϕ-ed. According to some philosophers who hold this view, all instances of gratitude to, or “prepositional gratitude,” are also instances of gratitude that, or “propositional gratitude.” These philosophers believe there is a single unified concept of gratitude, a phenomenon that is essentially gratitude that, and whose manifestations sometimes have additional features that make (...) them instances of gratitude to as well. In this article, I show that view to be mistaken. I base my argument on two hypothetical cases, in each of which a beneficiary, Y, is grateful to a benefactor, R, for ϕ-ing, but not grateful that R ϕ-ed. Generalizing from those cases and other cases of gratitude, I argue that prepositional gratitude is the proper response to benevolence-motivated action and propositional gratitude consists in a beneficiary’s judging a state of affairs to be valuable for himself and welcoming that state of affairs. Because not every instance of a benefactor’s acting benevolently toward a beneficiary is something that beneficiary finds valuable for himself and welcomes, it is possible to be grateful to a benefactor for ϕ-ing but not grateful that she ϕ-ed. Prepositional gratitude and propositional gratitude can each occur without the other and are thus two distinct phenomena. I conclude by explaining the importance of accurately understanding the relationship between prepositional gratitude and propositional gratitude. (shrink)

This article examines the distinction between judicial reasoning flawed by errors on questions of law, properly addressed on appeal, and errors that constitute judicial misconduct and are grounds for removal from the bench. Examples analysed are from the transcripts and reasons for decision in R v George SKQB (2015), appealed to the Saskatchewan Court of Appeal (2016) and the Supreme Court of Canada (2017), and from the sentencing decision rendered by the same judge more than a decade earlier in R (...) v Edmondson SKQB (2003). Both were sexual assault cases. In George a thirty-five year old woman with five children was tried and ultimately acquitted of sexual assault and sexual interference after she was assaulted in her home by a fourteen year old male. Striking similarities between the reasoning and language in the trial decision in George and the sentencing decision in Edmondson demonstrate entrenched antipathy for sexual assault law and the fundamental principles of justice, equality, and impartiality. This is arguably judicial misconduct, persisting despite access in the interim to many years of judicial education programming, not merely legal error. The problem does not lie with the judge alone, however. A toxic mix of misogyny and blindly zealous enforcement of the law appears to have undermined the administration of justice in George from the outset at all levels. The problems are systemic. Were this not the case, it is likely that Barbara George would not have been charged. (shrink)

Scholars are grateful to Cyril Lionel Robert James (1901-1989) and Herbert Aptheker (1915-2003) for their pioneering work in the field of slave revolts. What they've virtually never mentioned, however, let alone explored, was Aptheker’s practice of rendering James invisible. It is highly improbable that Aptheker did not know either of James or of his noteworthy study of the Haitian Revolution, given that the latter was related to the slave revolts that Aptheker did study. Aptheker’s neglect of James was not an (...) anomaly, but rather symptomatic of an ideology that rationalized extreme oppression. (shrink)

Science has always strived for objectivity, for a ‘‘view from nowhere’’ that is not marred by ideology or personal preferences. That is a lofty ideal toward which perhaps it makes sense to strive, but it is hardly the reality. This collection of thirteen essays assembled by Denis R. Alexander and Ronald L. Numbers ought to give much pause to scientists and the public at large, though historians, sociologists and philosophers of science will hardly be surprised by the material covered here.

Wild animal reproduction poses an important moral problem for animal rights theorists. Many wild animals give birth to large numbers of uncared-for offspring, and thus child mortality rates are far higher in nature than they are among human beings. In light of this reproductive strategy – traditionally referred to as the ‘r-strategy’ – does concern for the interests of wild animals require us to intervene in nature? In this paper, I argue that animal rights theorists should embrace fallibility-constrained interventionism: the (...) view that intervention in nature is desirable but should be constrained by our ignorance of the inner workings of ecosystems. Though authors sometimes assume that large-scale intervention requires turning nature into an enormous zoo, I suggest an alternative. With sufficient research, a new form of gene editing called CRISPR promises to one day give us the capacity to intervene without perpetually interfering with wild animals’ liberties. (shrink)

Conspectus of part of John R. Smythies' Analysis of Perception (1956). It presents a summary of his ideas on phenomenal space – the space of one’s imagination, dreams, psychedelic experiences, somatic sensations, visions, hynagogia, etc. – and its relation to physical space.

Abstract: In the present work we have made a critical review of the philosophical propo­ sal of Norwood R. Hanson with the aim of exposing the limits of its theoretical approach on the problem of interpretation in science. The first part of this work exposes the hansonian project, looking for evidence of his contributions to the philosophy of science and scientific thinking. In the following two sections we present a critique to his philosophical proposal. We present two exercises of philosophical (...) reflection that constitute two complementary moments of analysis. On one hand, at the level of methodological analysis, we present a discussion about how the “reversible perspective figures” that have been used for the author as arguments to explain his philosophical proposal, are insufficient to the descrip­ tion of the process of observation and interpretation. On the other hand, at the theoretical level, we question his notion of language and categories to show that his theoretical pro­ posed “vision-interpretation” has based on epistemological and analytic notions. From this perspective, it will be shown that the “hermeneutical-interpretative” approach of Hanson is incomplete, since it does not develop towards an ontology of language and observation. (shrink)

A review of Karen Bennett's /Making Things Up/.

This paper explores R. D. Laing's application of existential and phenomenological tradtions, specifically Hegel and Heidegger, to his groundbreaking work with psychotic process as well as psychotherapeutic practice more generally.

In her re-analysis of the evidence presented in Klein and Nichols (2012) to support their argument that patient R.B. temporarily lost possessory custody of consciously apprehended objects (in this case, objects that normally would be non-inferentially taken as episodic memory), Professor Roache concludes Klein and Nichols's claims are untenable. I argue that Professor Roache is incorrect in her re-interpretation, and that this is due, in part, to lack of sufficient familiarity with psychological theory on memory as well as clinical literature (...) on felt loss of ownership of one’s intentional objects. (shrink)

Mit seinem Einfluß auf die Entwicklung der Physiologie, Physik und Geometrie ist Hermann von Helmholtz wie kaum ein anderer Wissenschaftler der zweiten Hälfte des 19. Jahrhunderts repräsentativ für die Naturforschung in Deutschland. Nicht weniger repräsentativ nimmt sich die Entwicklung seiner Wissenschaftsauffassung aus. Während er bis in die späten 60er Jahre einen emphatischen Wahrheitsanspruch der Wissenschaft vertrat, begann er in der nachfolgenden Zeit, die Geltungsbedingungen der wissenschaftlichen Erkenntnis einer Relativierung zu unterwerfen, die zusammenfassend als Hypothetisierung bezeichnet werden kann. Helmholtz entwickelte damit (...) schon im vergangenen Jahrhundert Ansätze einer Wissenschaftsauffassung , die in erstaunlichem Umfang in die Richtung der Moderne weisen. Wie nah er späteren Wissenschaftsauffassungen bereits gekommen ist, kann ein Vergleich mit Karl R. Poppers Forschungslogik illustrieren. In seiner Forschungslogik ist die Hypothetisierung der wissenschaftlichen Erkenntnis entschieden weiter vorangeschritten als in Heimholtz' Wissenschaftstheorie. Was sich bei Helmholtz erst vage abzuzeichnen beginnt, ist bei ihm bereits explizit formuliertes Programm geworden. Obwohl HeImholtz und Popper in keiner direkten wissenschaftstheoretischen Entwicklungslinie stehen und Popper sich in seinen Schriften auch nur sehr selten und beiläufig auf Helmholtz bezieht, finden sich dennoch überraschende und bisher nicht beachtete Berührungspunkte, die insbesondere dann hervortreten, wenn man Heimholtz' Wissenschaftsauffassung vor dem Hintergrund von Poppers Forschungslogik betrachtet. (shrink)

Conspectus of part of John R. Smythies' Analysis of Perception (1956). It presents a summary of his ideas on phenomenal space – the space of one’s imagination, dreams, psychedelic experiences, somatic sensations, visions, hynagogia, etc. – and its relation to physical space.

Wilfred Sellars's deeply original and systematic thought continues to inspire into the twenty-first century. Part of the explanation must be that Sellars's struggle to integrate a Kantian-Wittgensteinian normative view of meaning and intentionality with a naturalistic outlook remains at the forefront of philosophical inquiry. To acknowledge the deep impact that Sellars has had on their work, a list of prominent, contemporary philosophers honor Sellars's legacy in a volume craftily edited by James R. O'Shea with a superb introduction. Like Sellars's own (...) work, the contributions are distributed across a wide range of topics from, roughly, philosophy of perception, philosophy of... (shrink)

With his influence on the development of physiology, physics and geometry, Hermann von Helmholtz – like few scientists of the second half of the 19th century – is representative of the research in natural science in Germany. The development of his understanding of science is not less representative. Until the late sixties, he emphatically claimed the truth of science; later on, he began to see the conditions for the validity of scientific knowledge in relative terms, and this can, in summary, (...) be referred to as hypothesizing. Already in the past century, HeImholtz made first approaches to an understanding of science, which were incompatible with his own former position and which pointed to the modern age to an astonishingly large extent. A comparison with Karl R. Popper's logic of research will illustrate how closely he nevertheless approached modern understanding of science. In Popper's logic of research, hypothesizing of scientific knowledge is definitely much more advanced than in Helmholtz's theory of science. What begins vaguely to emerge with Helmholtz has already become an explicitly formulated programme with Popper. Although HeImholtz and Popper are not on a direct line of epistemological development and Popper refers to HeImholtz only rarely and casually, there are in fact surprising points of contact which have not been taken notice of so far and which appear above all if one looks at Helmholtz's understanding of science against the background of Popper's logic of research. (shrink)

Review of: R. Steven Turner, In the Eye's Mind: Vision and the Helmholtz-Hering Controversy. xiv + 338 pp., frontis., illus., figs., tables, bibl., index. Princeton, N.J.: Princeton University Press, 1994.

Karen Stohr’s book On Manners argues persuasively that rules of etiquette, though conventional, play an essential moral role, because they “serve as vehicles through which we express important moral values like respect and consideration for the needs, ideas, and opinions of others”. Stohr frequently invokes Kantian concepts and principles in order to make her point. In Part 2 of this essay, I shall argue that the significance of etiquette is better understood using a virtue ethics framework, like that of (...) Confucianism, rather than the language of Kantianism. Within the Chinese tradition, Daoists have frequently been critics of Confucian ritualism. Consequently, in Part 3, I shall consider some possible Daoist critiques of Stohr’s work. (shrink)

A literary approach to scientific practice: Essay Review of R.I.G. Hughes' _The Theoretical Practices of Physics_.

A. Klimczuk, Book review: R. Sackmann, W. Bartl, B. Jonda, K. Kopycka, C. Rademacher, Coping with Demographic Change: A Comparative View on Education and Local Government in Germany and Poland, Cham, Heidelberg, Springer 2015, "Pol-int.org" 2017, https://www.pol-int.org/en/publications/coping-demographic-change-comparative-view-education-and#r59 41.

Personal Values is a delightful and enlightening read. It is teeming with novel insights, ground-breaking distinctions, rich examples, new delineations of the field, refreshing historical reminders, inventive arguments, unprecedented connections, identifications of neglected difficulties, and pioneering proposals. I shall focus here on three of these insights, which are illustrative of the pervasive scrupulousness and inventiveness of the book. The first is that there is a distinction between the supervenience base of values and their constitutive grounds. The second is that FA (...) is admittedly circular (because pro-attitudes have values as formal objects), but that this circularity is benign. The third proposal is that one important kind of for- someome-sake’s attitude⎯prototypically, love⎯is such that it is not justified by the properties it represents its object as exemplifying. This is a small sample of claims not meant to be representative of the book. The reason I have chosen to discuss these in particular is that, while finding them plausible and significant, I believe that each raises a worry that Rønnow-Rasmussen fails to address properly. I shall tentatively suggest a possible solution in each case. (shrink)

I gave the name “R theory of time " to the Buddhist philosophy of time in my 2005 article in The 'Indian International Journal of Buddhist Studies because after studying the currently discussed non Buddhist philosophies of time that have been offered to us by many physicists and analytic philosophers, I found that they seemed to not agree as much as I thought theories of time should with the findings of quantum physicists. Rather, the non Buddhist philosophies of time seemed (...) to only be in agreement with relativistic physics, but not at all in agreement with quantum physics. But on the other hand, it seemed to me that the Buddhist philosophy of time agreed best with quantum theory, and thus I published an article about the Buddhist philosophy of time in order to try to show why. (shrink)

In this short piece, I respond to Brian R. Clack's review of my book, Wittgenstein within the Philosophy of Religion.

We attribute three major insights to Hegel: first, an understanding of the real numbers as the paradigmatic kind of number ; second, a recognition that a quantitative relation has three elements, which is embedded in his conception of measure; and third, a recognition of the phenomenon of divergence of measures such as in second-order or continuous phase transitions in which correlation length diverges. For ease of exposition, we will refer to these three insights as the R First Theory, Tripartite Relations, (...) and Divergence of Measures. Given the constraints of space, we emphasize the first and the third in this paper. (shrink)

A longish (12 page) discussion of Richard Sorabji's excellent book, with a further discussion of what it means for a theory of emotions to be a cognitive theory.

据报道，越南人每年焚烧大约5万吨香纸，不仅是纸币形式， 还有iPhone、汽车、衣服， 甚至是管家形，希望取悦死者。 这种做法被错误地归因于传统的佛教教义，但大多数越南人都不知道它的起源來自于中国。 在生活的其他方面，越南也有许多类似的例子， 他们乐于對自己的文化增添新的规范、价值和信仰，甚至相互矛盾的東西。 这种被称为“文化可加性”的现象促使我们研究越南民间故事所显示的三教（儒教、佛教和道教）的核心价值观和规范之间的共存、相互作用和影响。通过应用贝叶斯逻辑回归，我们评估了一个故事的关键信息是否受宗教（因变 量）支配的可能性，還是受到三个教义有关的价值和反价值在表面的影响（自变量）。 我们的主要发现包括儒教和道教价值在文化上可加性的存在。更具体地说，实证结果表明，道教和儒教的价值观在民间故事中的相互作用或相加， 有助于预测故事的关键信息是否与儒教思想有关，β_{VT⋅VC} = 0.86。 同时，佛教却没有这样的统计趋势。 这些结果有一些重要意义。 首先，这表明了儒教思想的综治地位，因为儒教和道教的价值在一个故事中一起出现，导致了这个故事有儒学主导的关键信息。 因此，它表明了儒学支配地位的证据，并反对对三大宗教的共同根源，或是“三教同源” （“tam giáo đồng nguyên”） 概念的自由解释，认为宗教有统一性或唯一性。 其次，“文化可加性”概念有助于解释许多有趣的社会文化现象，就是越南社会没有不容忍和极端主义的宗教， 在教育里离谱诡辩的现象，科学技术的努力创造的效果低下， 商业中的误导品牌战略。我们知道我们的结果只是初步的， 并且必须进行更多的理论研究和实证研究， 以对 “文化可加性”有充分的解释。.

Amidst the constantly augmenting gastronomic capital of celebrity chefs, this study scrutinizes from a critical discourse analytic angle how Jamie Oliver has managed to carve a global brand identity through a process that is termed (dis)placed branding. A roadmap is furnished as to how Italy as place brand and Italianness are discursively articulated, (dis)placed and appropriated in Jamie Oliver’s travelogues which are reflected in his global brand identity. By enriching the CDA methodological toolbox with a deconstructive reading strategy, it is (...) shown that Oliver’s celebrity equity ultimately boils down to supplementing the localized meaning of place of origin with a simulacral, hyperreal place of origin. In this manner, the celebrity’s recipes become more original than the original or doubly original. The (dis)placed branding process that is outlined in the face of Oliver’s global branding strategy is critically discussed with reference to the employed discursive strategies, lexicogrammatical and multimodal choices. (shrink)

Every year, the Vietnamese people reportedly burned about 50,000 tons of joss papers, which took the form of not only bank notes, but iPhones, cars, clothes, even housekeepers, in hope of pleasing the dead. The practice was mistakenly attributed to traditional Buddhist teachings but originated in fact from China, which most Vietnamese were not aware of. In other aspects of life, there were many similar examples of Vietnamese so ready and comfortable with adding new norms, values, and beliefs, even contradictory (...) ones, to their culture. This phenomenon, dubbed “cultural additivity”, prompted us to study the co-existence, interaction, and influences among core values and norms of the Three Teachings –Confucianism, Buddhism, and Taoism–as shown through Vietnamese folktales. By applying Bayesian logistic regression, we evaluated the possibility of whether the key message of a story was dominated by a religion (dependent variables), as affected by the appearance of values and anti-values pertaining to the Three Teachings in the story (independent variables). Our main findings included the existence of the cultural additivity of Confucian and Taoist values. More specifically, empirical results showed that the interaction or addition of the values of Taoism and Confucianism in folktales together helped predict whether the key message of a story was about Confucianism, β{VT ⋅ VC} = 0.86. Meanwhile, there was no such statistical tendency for Buddhism. The results lead to a number of important implications. First, this showed the dominance of Confucianism because the fact that Confucian and Taoist values appeared together in a story led to the story’s key message dominated by Confucianism. Thus, it presented the evidence of Confucian dominance and against liberal interpretations of the concept of the Common Roots of Three Religions (“tam giáo đồng nguyên”) as religious unification or unicity. Second, the concept of “cultural additivity” could help explain many interesting socio-cultural phenomena, namely the absence of religious intolerance and extremism in the Vietnamese society, outrageous cases of sophistry in education, the low productivity in creative endeavors like science and technology, the misleading branding strategy in business. We are aware that our results are only preliminary and more studies, both theoretical and empirical, must be carried out to give a full account of the explanatory reach of “cultural additivity”. (shrink)