Significant associations have been found between specific human leukocyte antigen (HLA) alleles and organ transplant rejection, autoimmune disease development, and the response to infection. Traditional searches for disease associations have conventionally measured risk associated with the presence of individual HLA alleles. However, given the high level of HLA polymorphism, the pattern of amino acid variability, and the fact that most of the HLA variation occurs at functionally important sites, it may be that a combination of variable amino acid sites shared (...) by several alleles (shared epitopes) are better descriptors of the actual causative genetic variants. Here we describe a novel approach to genetic association analysis in which genes/proteins are broken down into smaller sequence features and then variant types defined for each feature, allowing for independent analysis of disease association with each sequence feature variant type. We have used this approach to analyze a cohort of systemic sclerosis patients and show that a sequence feature composed of specific amino acid residues in peptide binding pockets 4 and 7 of HLA-DRB1 explains much of the molecular determinant of risk for systemic sclerosis. (shrink)

America and the world are in the process of collapse from excessive population growth, most of it for the last century, and now all of it, due to 3rd world people. Consumption of resources and the addition of 4 billion more ca. 2100 will collapse industrial civilization and bring about starvation, disease, violence and war on a staggering scale. The earth loses about 2% of its topsoil every year, so as it nears 2100, most of its food growing capacity will (...) be gone. Billions will die and nuclear war is all but certain. In America, this is being hugely accelerated by massive immigration and immigrant reproduction, combined with abuses made possible by democracy. Depraved human nature inexorably turns the dream of democracy and diversity into a nightmare of crime and poverty. China will continue to overwhelm America and the world, as long as it maintains the dictatorship which limits selfishness. The root cause of collapse is the inability of our innate psychology to adapt to the modern world, which leads people to treat unrelated persons as though they had common interests. The idea of human rights is an evil fantasy promoted by leftists to draw attention away from the merciless destruction of the earth by unrestrained 3rd world motherhood. This, plus ignorance of basic biology and psychology, leads to the social engineering delusions of the partially educated who control democratic societies. Few understand that if you help one person you harm someone else—there is no free lunch and every single item anyone consumes destroys the earth beyond repair. Consequently, social policies everywhere are unsustainable and one by one all societies without stringent controls on selfishness will collapse into anarchy or dictatorship. The most basic facts, almost never mentioned, are that there are not enough resources in America or the world to lift a significant percentage of the poor out of poverty and keep them there. The attempt to do this is bankrupting America and destroying the world. The earth’s capacity to produce food decreases daily, as does our genetic quality. And now, as always, by far the greatest enemy of the poor is other poor and not the rich. Without dramatic and immediate changes, there is no hope for preventing the collapse of America, or any country that follows a democratic system. -/- Those interested in all my writings in their most recent versions may download from this site my e-book ‘Philosophy, Human Nature and the Collapse of Civilization Michael Starks (2016)- Articles and Reviews 2006-2016’ by Michael Starks First Ed. 662p (2016). -/- All of my papers and books have now been published in revised versions both in ebooks and in printed books. -/- Talking Monkeys: Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B071HVC7YP. -/- The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle--Articles and Reviews 2006-2016 (2017) https://www.amazon.com/dp/B071P1RP1B. -/- Suicidal Utopian Delusions in the 21st century: Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B0711R5LGX . (shrink)

Lilly was one of the greatest scientists and pioneers on the limits of human possibility but after his death a collective amnesia has descended and he is now almost forgotten. His Wiki is good but inevitably incomplete so here are a few missing details and viewpoints. Lilly was a generation (or more) ahead of his time. He is almost single-handedly responsible for the great interest in dolphins (which led to the Marine Mammal Protection Act in the USA and helped to (...) found the animal rights movement). In 1958 he noted that the brains of elephants and cetaceans were larger than ours, that we should not abuse them and that it was one our most important projects to communicate with them. He invented sensory isolation tanks (at NIMH in 1954) and used them extensively with and without powerful psychoactive drugs at a time when it was thought that either the brain would shut down or one would go insane if external stimuli were eliminated. He created methods for implanting electrodes in mammal brains and was planning to do it to himself. He was one of the first to make serious use of computers in bioscience research and created the hardware and software to make the first attempts to communicate with dolphins. He self experimented with dangerous physiological investigations in high altitude medicine for the military during WW2, took LSD with dolphins and movie stars, submitted himself to the rigors of various forms of yoga and of Arica training, and taught classes at Esalen. He was a computer pioneer who forsaw the rapid advances in A.I. and it's inevitable clash with humans. He was the first one to investigate the bizarre psychedelic ketamine (" vitamin K "), and his results (published in the two last chapters of his book `The Scientist`) are still the best data on the dose/effect relation of any psychedelic on one person. It cured his lifelong daily migraine headaches (see http://www.conspiracyarchive.com/UFOs/Gorightly.htm). And all this happened before most of us were born! He had courage, honesty and integrity that is rare anywhere and almost nonexistent in science. His goal was to find the ultimate truth about everything and he went about as far as anyone ever has. He had little patience with the stupid and hypocritical games one has to play to fit into monkey society. Of course the reaction of the establishment was predictable. He left the NIMH and was never given any government or academic support for the last 35 years of his life. His paper and comments at a conference on sensory deprivation were removed from the published version. He was not invited to government sponsored symposia on dolphins (he had refused to help develop them as weapons), though he clearly knew more about them than anyone in the world. He liked to live and work on the edge and few could keep up with him, as his books make clear. If you have read some of his other books it will be much easier going. He was a pioneer in consciousness research and pushed the boundaries of our understanding of who we are and what we might become. Among other things he catalogs the various states reached by drugs, meditation, and isolation, tries to determine their significance, and suggests how to use them. I very briefly review and comment on his life and work. -/- Those interested in all my writings in their most recent versions may download from this site my e-book ‘Philosophy, Human Nature and the Collapse of Civilization Michael Starks (2016)- Articles and Reviews 2006-2016’ by Michael Starks First Ed. 662p (2016). -/- All of my papers and books have now been published in revised versions both in ebooks and in printed books. -/- Talking Monkeys: Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B071HVC7YP. -/- The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle--Articles and Reviews 2006-2016 (2017) https://www.amazon.com/dp/B071P1RP1B. -/- Suicidal Utopian Delusions in the 21st century: Philosophy, Human Nature and the Collapse of Civilization - Articles and Reviews 2006-2017 (2017) https://www.amazon.com/dp/B0711R5LGX -/- . (shrink)

Passion is a hidden issue behind or at the heart of, contemporary theoretical debates about nationalism, identity politics and religious fundamentalism. It is not that reason and passion cannot be conceptually distinguished. They are, however, always entangled in practice - and this entanglement itself requires a conceptual account. So it is my ambition to blur the line between reason and passion: to rationalize (some of) the passions and to impassion reason. Passionate intensity has a legitimate place in the social world. (...) This extension of rational legitimacy to the political passions seems to me a useful revision of liberal theory which has been too pre-occupied in recent years with the construction of dispassionate deliberative procedures. It opens the way for better accounts of social connection and conflict and for more explicit and self-conscious answers to the unavoidable political questions: which side are you on? Key Words: conviction • interest • liberalism • passion • politics • Yeats. (shrink)

The predominant view in developmental psychology is that young children are able to reason with the concept of desire prior to being able to reason with the concept of belief. We propose an explanation of this phenomenon that focuses on the cognitive tasks that competence with the belief and desire concepts enable young children to perform. We show that cognitive tasks that are typically considered fundamental to our competence with the belief and desire concepts can be performed with the concept (...) of desire in the absence of competence with the concept of belief, whereas the reverse is considerably less feasible. (shrink)

We argue that many recent philosophical discussions about the reference of everyday concepts of intentional states have implicitly been predicated on descriptive theories of reference. To rectify this, we attempt to demonstrate how a causal theory can be applied to intentional concepts. Specifically, we argue that some phenomena in early social de- velopment ðe.g., mimicry, gaze following, and emotional contagionÞ can serve as refer- ence fixers that enable children to track others’ intentional states and, thus, to refer to those states. (...) This allows intentional concepts to be anchored to their referents, even if folk psy- chological descriptions turn out to be false. (shrink)

In the exploratory study reported here, we tested the efficacy of an intervention designed to train teenagers with Möbius syndrome (MS) to increase the use of alternative communication strategies (e.g., gestures) to compensate for their lack of facial expressivity. Specifically, we expected the intervention to increase the level of rapport experienced in social interactions by our participants. In addition, we aimed to identify the mechanisms responsible for any such increase in rapport. In the study, five teenagers with MS interacted with (...) three naïve participants without MS before the intervention, and with three different naïve participants without MS after the intervention. Rapport was assessed by self-report and by behavioral coders who rated videos of the interactions. Individual non-verbal behavior was assessed via behavioral coders, whereas verbal behavior was automatically extracted from the sound files. Alignment was assessed using cross recurrence quantification analysis and mixed-effects models. The results showed that observer-coded rapport was greater after the intervention, whereas self-reported rapport did not change significantly. Observer-coded gesture and expressivity increased in participants with and without MS, whereas overall linguistic alignment decreased. Fidgeting and repetitiveness of verbal behavior also decreased in both groups. In sum, the intervention may impact non-verbal and verbal behavior in participants with and without MS, increasing rapport as well as overall gesturing, while decreasing alignment. (shrink)

Subjectivism about normativity (SN) is the view that norms are never intrinsic to things but are instead always imposed from without. After clarifying what SN is, I argue against it on the basis of its implications concerning intentionality. Intentional states with the mind-to-world direction of fit are essentially norm-subservient, i.e., essentially subject to norms such as truth, coherence, and the like. SN implies that nothing is intrinsically an intentional state of the mind-to-world sort: its being such a state is only (...) a status relative to the imposition of a norm. If one rejects this view of mind-to-world states, then one has grounds for rejecting SN itself. If one accepts it, an infinite regress arises that makes it impossible for norms to be imposed, which means that SN has undermined itself. (shrink)

Suppose a fire broke out in a fertility clinic. One had time to save either a young girl, or a tray of ten human embryos. Would it be wrong to save the girl? According to Michael Sandel, the moral intuition is to save the girl; what is more, one ought to do so, and this demonstrates that human embryos do not possess full personhood, and hence deserve only limited respect and may be killed for medical research. We will argue, (...) however, that no relevant ethical implications can be drawn from the thought experiment. It demonstrates neither that one always ought to let the embryos die, nor does it allow for any general conclusion concerning the moral status of human embryos. (shrink)

I provide a critical survey of some of the major findings of Wittgenstein and Searle on the logical structure of intentionality (mind, language, behavior), taking as my starting point Wittgenstein’s fundamental discovery –that all truly ‘philosophical’ problems are the same—confusions about how to use language in a particular context, and so all solutions are the same—looking at how language can be used in the context at issue so that its truth conditions (Conditions of Satisfaction or COS) are clear. The basic (...) problem is that one can say anything but one cannot mean (state clear COS for) any arbitrary utterance and meaning is only possible in a very specific context. I begin with ‘On Certainty’ and continue the analysis of recent writings by and about them from the perspective of the two systems of thought, employing a new table of intentionality and dual systems nomenclature. (shrink)

This article presents a critical analysis of two influential readings of Kant’s Second Analogy, namely, Gerd Buchdahl’s “modest reading” and Michael Friedman’s “strong reading.” After pointing out the textual and philosophical problems with each, I advance an alternative reading of the Second Analogy argument. On my reading, the Second Analogy argument proves the existence of necessary and strictly universal causal laws. This, however, does not guarantee that Kant has a solution for the problem of induction. After I explain why (...) the empirical lawfulness of nature does not guarantee the empirical uniformity of nature, I examine the modal status of empirical laws in Kant and argue contra Buchdahl and Friedman that empirical laws express two different kinds of necessity that are not reducible to each other. -/- . (shrink)

Michael Sandel’s latest book is not a scholarly work but is clearly intended as a work of public philosophy—a contribution to public rather than academic discourse. The book makes two moves. The first, which takes up most of it, is to demonstrate by means of a great many examples, mostly culled from newspaper stories, that markets and money corrupt—degrade—the goods they are used to allocate. The second follows from the first as Sandel’s proposed solution: we as a society should (...) deliberate together about the proper meaning and purpose of various goods, relationships, and activities (such as baseball and education) and how they should be valued. -/- Public philosophy is a different genre from academic philosophy, but that does not mean that it cannot be held to high standards. In my view, while this book does provide food for thought and food for conversation, it nevertheless has significant failings as a work of public philosophy rather than journalistic social activism on the model of Naomi Klein’s No logo (1999). (shrink)

To combat the ecological crisis, fundamental change is required in how humans perceive nature. This paper proposes that the human-nature bifurcation, a metaphysical mental model that is deeply entrenched and may be environmentally unsound, stems from embodied and tacitly-held substance-biased belief systems. Process philosophy can aid us, among other things, in providing an alternative framework for reinterpreting this bifurcation by drawing an ontological bridge between humans and nature, thus providing a coherent philosophical basis for sustainable dwelling and policy-making. Michael (...) Polanyi's epistemology can further help us understand these environmentally-oriented tacit processes of knowing, and also provide a basis for the political and educational implementation of process-philosophical insights, particularly via the nudging of mental models. (shrink)

A review of Michael Madary's book Visual Phenomenology.

Given the ascribed antinaturalist theory of judgment, Green’s Nietzsche cannot stop with the error theory. “Kant and Spir argue that the only way an objectively valid judgment about an object is possible is if the qualities attributed to the object are unconditionally united in the mind, that is, united in an atemporal and necessary manner”. Thoughts, and the subjects that have them, must be timeless. There must also be a “necessary connection between thought and its object”. Reality, on the other (...) hand, isn’t timeless: there is change, or becoming—this is Nietzsche’s naturalism. Thus, the connection between thoughts and reality fails, there is no timeless subject to have thoughts, and so: “We do not think”. It follows that there are no thoughts to be false—no error theory—and naturalism itself “cannot be thought”. Green calls this Nietzsche’s “noncognitivism” and concludes that the contradictions between Nietzsche’s naturalism, error theory, and noncognitivism mean that he “did not have one considered epistemological position” —a rather mild way of putting it. (shrink)

Michael Devitt develops a hybrid causal theory of non-empty proper names and certain singular terms that semantically resemble them. He considers that the use of a name designates an object not by virtue of the different information we know about it, but by a causal network that starts from the first uses of the name to designate the object, through a "reference borrowing" from the previous uses. DOI: 10.13140/RG.2.2.35828.50564.

Michael Devitt dezvoltă o teorie cauzală hibridă a numelor proprii negoale și a anumitor termeni singulari care seamănă semantic cu acestea. Acesta consideră că utilizarea unui nume, desemnează un obiect nu în virtutea diferitelor informații pe care le știm despre el, ci a unei rețele de cauzalitate care începe de la primele utilizări ale numelui pentru a desemna obiectul, printr-un "împrumut de referință" de la utilizările anterioare. DOI: 10.13140/RG.2.2.25499.41769.

I review Michael T. Ferejohn's "Formal Causes: Definition, Explanation, and Primacy in Socratic and Aristotelian Thought".

Michael Crichton‟s latest novel Next (2006) is his third about genomics. Yet, whereas Jurassic Park (and its sequel The lost world) contained stories about sequencing, reconstructing and revivifying the genomes of (extinct) animals, Next analyses the impact of genomics in the biomedical sphere: its consequences for human life (health, labour, sexuality, family life). Gene patenting, and the philosophy of genetic determinism that inspired and legitimised this practice, is at the root of most of the soap-like absurdities Crichton stages in (...) his novel. (shrink)

This article explores the implications of Michael Polanyi's concept of Tacit Knowledge for religious belief in general, and Christianity in particular, by investigating the relationship of tacit knowledge to commitment in scientific investigation, and extrapolating that relationship to commitments in the area of religious belief.

This interview was carried out on 13 December 2018 as Michael Williams was in Porto for a meeting of the Contextualism Network organised by the MLAG – Mind, Language, and Action Research Group (Institute of Philosophy of the University of Porto). We would like to thank him for his willingness to reply to our questions. -/- .

In 1949, the Department of Philosophy at the University of Manchester organized a symposium “Mind and Machine” with Michael Polanyi, the mathematicians Alan Turing and Max Newman, the neurologists Geoff rey Jeff erson and J. Z. Young, and others as participants. Th is event is known among Turing scholars, because it laid the seed for Turing’s famous paper on “Computing Machinery and Intelligence”, but it is scarcely documented. Here, the transcript of this event, together with Polanyi’s original statement and (...) his notes taken at a lecture by Jeff erson, are edited and commented for the fi rst time. Th e originals are in the Regenstein Library of the University of Chicago. Th e introduction highlights elements of the debate that included neurophysiology, mathematics, the mind-body-machine problem, and consciousness and shows that Turing’s approach, as documented here, does not lend itself to reductionism. (shrink)

In this book, law professors Sherry F. Colb and Michael C. Dorf argue that: -/- many non-human animals, at least vertebrates, are morally considerable and prima facie wrong to harm because they are sentient, i.e., conscious and capable of experiencing pains and pleasures; most aborted human fetuses are not sentient -- their brains and nervous systems are not yet developed enough for sentience -- and so the motivating moral concern for animals doesn't apply to most abortions[2]; later abortions affecting (...) sentient fetuses, while rare, raise serious moral concerns, but these abortions -- like all abortions -- invariably involve the interests and rights of the pregnant woman, which can make these abortions morally permissible. For a book claiming to explore the "connections" between debates about the two issues, just the summary from the book flap -- basically, what's above -- makes it appear that there really isn't much connection between the topics, at least at the core ethical level. Animals are sentient, early fetuses are not, and so the moral arguments about the two issues don't overlap or share premises. While the authors hope to use insights from one issue to shed light on the other, I find that differences in the issues limit these insights. (shrink)

The Event of the Thing by Michael Marder is probably one of the most comprehensive and integrative readings of Derrida's oeuvre to date. A virtue of the book is that, despite the comprehensiveness of its subject matter, it does not assume the removed posture of an introduction, an exposition, or an explication. Its relation to the Derridian text is much more internal and intimate, and it should be noted that it presupposes a rather thorough knowledge of Derrida's oeuvre as (...) well as of Derrida's philosophical “reading list” (primarily Husserl, Heidegger, Freud, Marx, and Kant). Marder's confident and elegant prose reveals…. (shrink)

Timothy Michael Fowler has argued that, as a consequence of their commitment to neutrality in regard to comprehensive doctrines, political liberals face a dilemma. In essence, the dilemma for political liberals is that either they have to give up their commitment to neutrality (which is an indispensible part of their view), or they have to allow harm to children. Fowler’s case for this dilemma depends on ascribing to political liberals a view which grants parents a great degree of freedom (...) in deciding on the education of their children. I show that ascribing this view to political liberals rests upon a misinterpretation of political liberalism. Since political liberals have access to reasons based upon the interests of children, they need not yield to parent’s wishes about the education of their children. A correct understanding of political liberalism thus shows that political liberals do not face the dilemma envisaged by Fowler. (shrink)

This is a review and critical commentary on Michael Plaxton's 2015 book, Implied Consent and Sexual Assault, in which he proposes that the legal definition of sexual consent be amended to permit sexual partners to define the terms and conditions of sexual consent in accordance with private "normative commitments" between themselves. The proposed "reform" is intended to permit an individual to agree to be a party to sexual activity that would otherwise constitute sexual assault under Canadian law. For reasons (...) explained in the review, this reviewer concludes that Plaxton's proposal and the rationale he presents in support of its adoption are unpersuasive. (shrink)

This is a review of Michael Kelly's _Iconoclasm in Aesthetics_.

A critical review of Michael Ridge's book Impassioned Belief.

A long critical notice of Michael Forster's recent book, "Kant and Skepticism." We argue that Forster's characterization of Kant's response to skepticism is both textually dubious and philosophically flawed. -/- .

This is a rough translation of Michael Frede's "La théorie aristotélicienne de l'intellect agent" published in 1996. This insightful paper contains an important interpretation of Aristotle's notoriously difficult theory of the active intellect from De Anima III, 5. I worked up a translation during some research and thought others might benefit from having an English translation available (I couldn't find one after a cursory internet search). It's not perfect, but it should give one a sense for Frede's argument that (...) the agent intellect is the same as the divine intellect of Metaphysics Lambda. I welcome any comments or suggestions for improvement, please email me at smurray8@nd.edu. (shrink)

Michael Hunter, The Boyle Papers: Understanding the Manuscripts of Robert Boyle. With contributions by Edward B. Davis, Harriet Knight, Charles Littleton and Lawrence M. Principe. Aldershot, England; Burlington, VT: Ashgate, 2007. Pp. xiii + 674. US$139.95/£70.00 HB. -/- The publication by Michael Hunter of this revised edition of the catalogue of the Boyle Papers contributes admirably to the renaissance in Boyle studies which has taken place over the past decade and a half. Robert Boyle (1627–91), arguably the most (...) influential British scientist of the late seventeenth century, was a pioneering experimenter, profound thinker, and figure-head of the new science in its early years of development. This volume brings together the materials necessary for understanding the Boyle archive, one of the most important archives from this period, which has been at the Royal Society since 1769. (shrink)

Review of "Goods and Virtues" by Michael Slote.

An extensive review of Michael Friedman's recent book.

Michael Quante’s book Person offers a systematic and argumentative assessment of the question what a person is and accounts for the multiple aspects that play a role in our everyday understanding of the term. Quante is skeptical about the possibility of constructing a purely psychological account of the person and proposes to base the diachronic unity conditions of persons on the human organism. At the same time he acknowledges that psychological considerations, including the notion of a person’s personality, are (...) important for practical purposes. However, one may wonder why he proposes the human organism as the remedy for the alleged shortcomings of the psychological approach, rather than introducing an additional physical continuity requirement of the cerebrum or other parts of the brain. (shrink)

Review of Truth and Realism, edited by Patrick Greenough and Michael Lynch.

Do frogs have lips? In thinking of an answer to this question, many people form a mental image of a frog and scrutinise it to find the answer. But what are they doing when they do this? The imagery debate that Michael Tye addresses in this book is between two kinds of answer to this question: the "pictorialist" answer that images are in important ways like pictures, and the "descriptionalist" answer that they are more like descriptions. Versions of these (...) views have been held both by philosophers and psychologists. Tye's book aims to disentangle the various claims made by pictorialists and descriptionalists and to defend a theory which incorporates elements from the description and picture theories. (shrink)

The Routledge Companion to Virtue Ethics, edited by Lorraine Besser-Jones and Michael Slote, is unusual among the recent crop of handbooks, encyclopedias, and compendiums in philosophy in a couple of respects. First, as well as presenting up-to-date surveys of the field, the Companion includes a number of entries that also engage in argument and negotiate tensions between different positions—some even questioning the nature of virtue ethics itself. These chapters are particularly interesting as they demonstrate the use of philosophical methodology (...) in debates about VE. Second, the volume engages with non-Western perspectives on virtue theory and VE, with several chapters showing the... (shrink)

La teoria del potere di Michael Mann è una delle prospettive più influenti nell’ambito della ricerca sul potere contemporanea. La sua grande carica innovativa è data dal modello teorico che Mann elabora nella sua opera più ampia e conosciuta, The Sources of Social Power: le relazioni di potere succedutesi nella storia umana possono essere ripercorse e spiegate sulla base delle quattro categorie costituite dal potere ideologico, economico, militare e politico. Grazie a questa chiave analitica Mann offre risposte empiricamente documentate (...) e teoricamente affascinanti a fondamentali interrogativi storico-politici: come e perché sono sorte le prime grandi civiltà dell’antichità? Come si è generata la proprietà privata? In che modo sono nati gli Stati nazionali? A quali condizioni può prodursi una rivoluzione? Il volume ripercorre, e discute criticamente, il complesso delle ricerche svolte da Mann; esse, facendo luce sul passato, offrono una chiave originale per capire come si è formata la società in cui viviamo, e ci permettono di valutare più chiaramente, in quanto studiosi e cittadini, le scelte che ci si prospettano per il futuro. (shrink)

Philosophy, that most misunderstood of intellectual pursuits, is often mocked; and no part of philosophy is as often mocked as metaphysics. The image of the ‘speculative metaphysician’ dreaming up abstract pictures of the world has been held up for ridicule by poets, playwrights, novelists, journalists as well as by other philosophers. The Logical Positivists in the first half of the 20th Century rejected all metaphysical speculations as ‘meaningless’ since they could not be verified by scientific experiment; in the later part (...) of the century, Wittgenstein criticised systematic metaphysics as being a kind of intellectual disease resulting from our reading false pictures of the world into the grammar of our language. The common suspicion underlying many of these attacks is that ultimately, all metaphysics is a kind of nonsense, and that metaphysicians don’t really know what they are talking about. This suspicion is not new. Nicolas-Sébastien Chamfort commented in 1796, ‘I am tempted to say of metaphysicians what Scaliger used to say of the Basques: they are said to understand one another, but I don’t believe a word of it.’ Some contemporary philosophers may agree. (shrink)