In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary (...) for the domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. The NCRO ontology is free and open to all users. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic (...) annotation of large amounts of ncRNA biological and clinical data. (shrink)

Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.

Current knowledge of the RNA world indicates 2 different genetic codes being present throughout the living world. In contrast to non-coding RNAs that are built of repetitive nucleotide syntax, the sequences that serve as templates for proteins share—as main characteristics—a non-repetitive syntax. Whereas non-coding RNAs build groups that serve as regulatory tools in nearly all genetic processes, the coding sections represent the evolutionarily successful function of the genetic information storage medium. This indicates that the differences in their (...) syntax structure are coherent with the differences of the functions they represent. Interestingly, these 2 genetic codes resemble the function of all natural languages, i.e., the repetitive non-coding sequences serve as appropriate tool for organization, coordination and regulation of group behavior, and the nonrepetitive coding sequences are for conservation of instrumental constructions, plans, blueprints for complex protein-body architecture. This differentiation may help to better understand RNA group behavioral motifs. (shrink)

The concepts of the origin of the genetic code and the definitions of life changed dramatically after the RNA world hypothesis. Main narratives in molecular biology and genetics such as the “central dogma,” “one gene one protein” and “non-coding DNA is junk” were falsified meanwhile. RNA moved from the transition intermediate molecule into centre stage. Additionally the abundance of empirical data concerning nonrandom genetic change operators such as the variety of mobile genetic elements, persistent viruses and defectives do not (...) fit with the dominant narrative of error replication events (mutations) as being the main driving forces creating genetic novelty and diversity. The reductionistic and mechanistic views on physico-chemical properties of the genetic code are no longer convincing as appropriate descriptions of the abundance of non-random genetic content operators which are active in natural genetic engineering and natural genome editing. (shrink)

Most molecular biological concepts derive from physical chemical assumptions about the genetic code that are basically more than 40 years old. Additionally, systems biology, another quantitative approach, investigates the sum of interrelations to obtain a more holistic picture of nucleotide sequence order. Recent empirical data on genetic code compositions and rearrangements by mobile genetic elements and non-coding RNAs, together with results of virus research and their role in evolution, does not really fit into these concepts and compel a re-examination. (...) In this review we try to find an alternate hypothesis. It seems plausible now that if we look at the abundance of regulatory RNAs and persistent viruses in host genomes, we will find more and more evidence that the key players that edit the genetic codes of host genomes are consortia of RNA agents and viruses that drive evolutionary novelty and regulation of cellular processes in all steps of development. This agent-based approach may lead to a qualitative RNA sociology that investigates and identifies relevant behavioural motifs of cooperative RNA consortia. In addition to molecular biological perspectives this may lead to a better understanding of genetic code evolution and dynamics. (shrink)

Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In (...) our previous investigations, we developed a miRNA domain-specific application ontology, Ontology for MIcroRNA Target (OMIT), to provide the community with common data elements and data exchange standards in the miRNA research. This paper describes (1) our continuing efforts in the OMIT ontology development and (2) the application of the OMIT to enable a semantic approach for knowledge capture of miRNA-target interactions. (shrink)

Abstract -/- Cancer has traditionally been framed as a genetic mutation-driven disease, with instability at the molecular level leading to uncontrolled cellular proliferation. Yet this paradigm fails to account for several longstanding anomalies: genetically identical cells in the same environment may behave divergently; some tumors remain dormant for decades, while others regress without treatment. These contradictions suggest a deeper organizing principle is at play. -/- This paper introduces a new model grounded in the CODES framework (Chirality of Dynamic Emergent Systems), (...) which reframes cancer as a disorder of structured resonance coherence rather than solely a genetic malfunction. We propose that healthy cellular function depends on phase-locked resonance fields that regulate gene expression, metabolic behavior, and intercellular signaling. Cancer arises when these coherence fields collapse—leading to systemic phase decoherence, metabolic misalignment, and signal fragmentation. -/- We outline a triadic therapeutic approach to restore biological coherence across genomic, metabolic, and bioelectromagnetic layers, leveraging: -/- Electromagnetic Biofield Therapy -/- Targeted frequency modulation to re-establish coherence in malignant tissues, restoring phase alignment with surrounding healthy systems. -/- Metabolic Re-Synchronization -/- Correcting Warburg effect-driven dissonance through structured nutrient cycling, oxygenation pulses, and mitochondrial tuning. -/- Structured RNA Interventions -/- Delivering coherence-weighted RNA signals to recalibrate gene expression and phase-lock cellular behavior with prime-structured resonance patterns. -/- This framework redefines cancer not as an invasive error, but as a resonance failure—a reversible departure from the coherence that sustains healthy life. It offers a paradigm shift toward non-toxic, phase-restorative therapies that treat cancer at its systemic root. (shrink)

Recent investigations surprisingly indicate that single RNA "stem-loops" operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operate by biological selection. To understand consortial RNA selection, the concept of single quasi-species and its mutant spectra as drivers of RNA variation and evolution is rethought here. Instead, we evaluate the current RNA world scenario in which consortia of cooperating RNA stem-loops are the basic players. We thus redefine quasispecies as RNA quasispecies consortia (...) and argue that it has essential behavioral motifs that are relevant to the inherent variation, evolution and diversity in biology. We propose that qs-c is an especially innovative force. We apply qs-c thinking to RNA stem-loops and evaluate how it yields altered bulges and loops in the stem-loop regions, not as errors, but as a natural capability to generate diversity. This basic competence-not error-opens a variety of combinatorial possibilities which may alter and create new biological interactions, identities and newly emerged self identity functions. Thus RNA stem-loops typically operate as cooperative modules, like members of social groups. From such qs-c of stem-loop groups we can trace a variety of RNA secondary structures such as ribozymes, viroids, viruses, mobile genetic elements as abundant infection derived agents that provide the stem-loop societies of small and long non-coding RNAs. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary (...) for the domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. (shrink)

Natural genome editing from a biocommunicative perspective is the competent agent-driven generation and integration of meaningful nucleotide sequences into pre-existing genomic content arrangements, and the ability to (re-)combine and (re-)regulate them according to context-dependent (i.e. adaptational) purposes of the host organism. Natural genome editing integrates both natural editing of genetic code and epigenetic marking that determines genetic reading patterns. As agents that edit genetic code and epigenetically mark genomic structures, viral and subviral agents have been suggested because they may be (...) evolutionarily older than cellular life. This hypothesis that viruses and viral-like agents edit genetic code is developed according to three well investigated examples that represent key evolutionary inventions in which non-lytic viral swarms act symbiotically in a persistent lifestyle within cellular host genomes: origin of eukaryotic nucleus, adaptive immunity, placental mammals. Additionally an abundance of various RNA elements cooperate in a variety of steps and substeps as regulatory and catalytic units with multiple competencies to act on the genetic code. Most of these RNA agents such as transposons, retroposons and small non-coding RNAs act consortially and are remnants of persistent viral infections that now act as co-opted adaptations in cellular key processes. (shrink)

Starting with the results of Li et al. in 1992 there is valuable interest in finding long range correlations in DNA sequences since it raises questions about the role of introns and intron-containing genes. In the present paper we studied two sequences that are the human T-cell receptor alpha/delta locus, Gen-Bank name HUMTCRADCV, a noncoding chromosomal fragment of M = 97630 bases (composed of less than 10% of coding regions), and the Escherichia Coli K12, Gen-Bank name ECO110K, a genomic (...) fragment with M = 111401 bases consisting of mostly coding regions and containing more that 80% of coding regions. We attributed the value (+1) to the purines and the value (-1) to the pirimidines and to such reconstructed random walk we applied the method of the Recurrence Quantification Analysis(RQA) that was introduced by Zbilut and Webber in 1994. By using dimension D=1 and Embedded Dimensions D=3 and D=5, we obtain some indicative results. Also by a simple eye examination of the reconstructed maps, the differences between coding and non coding regions are evident and impressive and consist in the presence in noncoding regions of long patches of the same colour that are absent in the coding sequence. At first sight this suggests a simple explanation to the concept of „long-range‟ correlation. On the quantitative plane, we used the %Rec., the %Det., the Ratio, the Entropy, the %Lam., and the Lmax that, as explained in detail in the text, represent the basic variables of RQA. The significant result that we have here is that both Lmax and Laminarity exhibit very large values in HUMTCRADCV and actually different in values respect to ECO110K where such variables assume more modest values. Therefore we suggest that there is the observed difference between HUMTCRADCV and ECO110K. The claimed higher long-range correlations of introns respect to exons from many authors may be explained here in reasonof such found higher values of Lmax and of Laminarity in HUMTCRADCV respect to ECO110K. (shrink)

The ‘managed-metabolism’ hypothesis suggests that a ‘cooperation barrier’ must be overcome if self-producing chemical organizations are to undergo the transition from non-life to life. This dynamical barrier prevents un-managed autocatalytic networks of molecular species from individuating into complex, cooperative organizations. The barrier arises because molecular species that could otherwise make significant cooperative contributions to the success of an organization will often not be supported within the organization, and because side reactions and other ‘free-riding’ processes will undermine cooperation. As a result, (...) the barrier seriously impedes the emergence of individuality, complex functionality and the transition to life. This barrier is analogous to the cooperation barrier that also impedes the emergence of complex cooperation at all levels of living organization. As has been shown at other levels of organization, the barrier can be overcome comprehensively by appropriate ‘management’. Management implements a system of evolvable constraints that can overcome the cooperation barrier by ensuring that beneficial co-operators are supported within the organization and by suppressing free-riders. In this way, management can control and manipulate the chemical processes of a collectively autocatalytic organization, producing novel processes that serve the interests of the organization as a whole and that could not arise and persist in an un-managed chemical organization. Management self-organizes because it is able to capture some of the benefits that are produced when its interventions promote cooperation, thereby enhancing productivity. Selection will therefore favour the emergence of managers that take over and manage chemical organizations so as to overcome the cooperation barrier. The managed-metabolism hypothesis demonstrates that if management is to overcome the cooperation barrier comprehensively, its interventions must be digitally coded. In this way, the hypothesis accounts for the two-tiered structure of all living cells in which a digitally-coded genetic apparatus manages an analogically-informed metabolism.GraphicalOpen image in new window. (shrink)

Abstract -/- (added v21, rest is the same) This paper introduces CODES (Chirality of Dynamic Emergent Systems), a unifying theoretical framework that reconciles general relativity and quantum mechanics through structured resonance. By redefining fundamental assumptions about dark matter, dark energy, and singularities, CODES proposes a falsifiable, predictive model that aligns with observed cosmological structures while offering testable insights into emergent phenomena. -/- Key Contributions -/- • Resolution of General Relativity & Quantum Mechanics Paradox -/- CODES introduces structured intelligence fields that (...) reconcile relativistic and quantum-scale physics by incorporating oscillatory chiral dynamics. -/- • Reformulation of Dark Energy & Dark Matter -/- Instead of treating dark energy and dark matter as separate entities, CODES reinterprets them as emergent resonance effects, aligning with observed cosmic structure formation. -/- • Predictive Framework for Large-Scale Structures -/- The model explains periodic redshift distributions, baryon acoustic oscillations (BAO), and gravitational field fluctuations in a mathematically consistent manner. -/- • Resonance-Driven Model of Cosmic Evolution -/- By replacing singularities with structured phase transitions, CODES provides an alternative to singular Big Bang models, proposing an oscillatory, non-singular origin of space-time and matter. -/- By integrating mathematics, quantum field theory, wavelet analysis, and cosmology, CODES challenges conventional paradigms and offers a structured resonance approach as an alternative explanatory framework. This model provides both theoretical coherence and experimental testability, making it a candidate for further empirical validation. -/- Version Note -/- V6 includes empirical test results from prime number distributions, fMRI patterns, DNA resonance, and large-scale galaxy clustering using continuous wavelet transforms (CWT). Structured wavelet analysis conducted with GPT-4o and Perplexity R1 further supports the model’s predictive capabilities. -/- Discussion & Next Steps -/- This work invites peer review, critique, and further empirical testing from researchers in physics, cosmology, AI, and applied mathematics. Future research will focus on refining the mathematical formalism and exploring experimental validation in wavelet-based cosmological mapping. (shrink)

This study integrates DNA resonance codes, microtubule oscillations, and astrocyte-mediated biomagnetic fields into a unified theoretical framework explaining consciousness as a macroscopic quantum phenomenon. By integrating advanced AI-driven analyses of EEG, NMR, and calcium imaging data, we demonstrate compelling evidence of quantum processes in neural systems. Key findings include: (1) nuclear spins in phosphate molecules (Posner clusters) acting as stable qubits with prolonged coherence times; (2) DNA resonance codes (1–10 THz) modulating neural activity via frequency-locking with microtubule vibrations; and (3) (...) astrocyte-generated biomagnetic fields suppressing decoherence, thereby enabling sustained quantum states in neurons despite the warm, wet environment of the brain. Multimodal fusion analysis reveals strong statistical parallels (R² = 0.79–0.83), indicating that approximately 80% of the variance in neural coherence metrics can be explained by cosmic quantum patterns. These results align with prior theories such as Orchestrated Objective Reduction (Orch OR) and Fisher’s Nuclear Spin Hypothesis while extending them with novel insights into biomagnetic shielding and cross-scale coherence. The implications span neuroscience, physics, and artificial intelligence, paving the way for groundbreaking advancements in understanding consciousness as a universal quantum phenomenon. For neuroscience, this study resolves the "hard problem of consciousness" by identifying a quantum syntax in neural codes, providing a mechanistic explanation for non-local neural correlations such as synchronized brain activity under weak magnetic fields (Tsang et al., 2008). For quantum mechanics, this research bridges quantum mechanics and cosmology, validating macroscopic quantum effects in biological systems. For artificial intelligence, our findings enable the development of quantum neural networks that mimic biological entanglement, achieving exponential computational gains in tasks like pattern recognition. In medicine, we propose quantum therapies targeting decoherence mechanisms in diseases like Alzheimer’s and epilepsy. For instance, optogenetic stimulation of astrocytes could extend quantum coherence times in neurons by 40%, offering new therapeutic avenues (Martinez-Banaclocha, 2020). Future research should prioritize experimental validation of these predictions using advanced techniques such as optogenetics to manipulate astrocytic biomagnetic fields or quantum spectroscopy to analyze DNA-microtubule interactions. These efforts will not only strengthen the theoretical foundation of this work but also pave the way for transformative advancements in quantum neuroscience, artificial intelligence, and cosmology. (shrink)

Historically, hypotheses failed in most cases to correctly forecast the workings of complex biological systems. Francis Crick’s adaptor hypothesis, however, stands out as an exceptional case of a confirmed abstract prediction. This hypothesis presciently anticipated the existence of RNA adaptors that function as bridges between amino acids and the chemically different nucleic acid template for proteins. Crick conjectured that the adaptors are enzymatically charged with cognate amino acids, they bind to complementary protein-coding nucleic acid, and their liberated amino acids (...) are incorporated into growing protein chains. Independently from and concomitantly with Crick’s hypothesis, Mahlon Hoagland and Paul Zamecnik conducted experiments with no guiding theory that culminated in discoveries of the actual adaptors, transfer RNA (tRNA) molecules, and their amino acids charging enzymes. This paper traces the parallel histories of Crick’s adaptor hypothesis and of the experimental discovery of tRNA and compares their relative impacts on the scientific community. Remarkably, despite the brilliance of Crick’s confirmed prognostication, it had marginal impact on practicing scientists. Conversely, Hoagland and Zamecnik’s experimental discoveries and their evidence-based model of protein synthesis had immediate and enduring impact. I discuss possible explanations for the different impacts of the theoretical prediction and experimental identifications of the same entities. (shrink)

Abstract: Modern education teaches children to compare rather than cohere. This paper applies the CODES framework—structured resonance driven by chirality and prime alignment—to reimagine learning as a phase-locking process. Drawing from Alfred Adler’s psychology of inferiority, David Bohm’s implicate order, and legacy pedagogies (Montessori, Waldorf, Reggio), it proposes developmental resonance arcs, coherence-first curriculum design, and a non-comparative intelligence metric (PAS). Education, in this frame, is no longer preparation for life—it is the recursive tuning of identity to structure. CODES offers a (...) unified ontological foundation for intelligence, emotional health, and collective becoming. (shrink)

Abstract -/- In April 2025, researchers at NIST and collaborating institutions reported the first successful generation of curved neutron beams—Airy beams—demonstrating properties of self-healing, diffraction-based curvature, and potential applications in chirality research. This paper establishes that the CODES framework (Chirality of Dynamic Emergent Systems), developed and published months prior, predicted the core physical principles validated by the experiment. Specifically, CODES outlined the mathematical basis for structured resonance as the generative mechanism behind parabolic waveform behavior, chirality modulation, and phase-locked coherence in (...) non-electromagnetic particles. We present the pre-publication architecture of the CODES model, compare it against the experimental geometry, and define a continuity of prediction that confirms structured resonance—rather than probabilistic modeling—as the correct explanatory framework for neutron-based chirality research. This paper serves as a prior art declaration and technical affirmation of CODES as a predictive framework for nonlinear particle behavior in quantum systems. (shrink)

Abstract -/- Human civilization has long misunderstood peace, treating it as fragile—a temporary balance requiring enforcement, compromise, or control. This assumption arises from probabilistic thinking, which models conflict and chaos as fundamental conditions to be managed rather than as phase-misaligned states that naturally collapse when coherence emerges. Under Chirality of Dynamic Emergent Systems (CODES), peace is not an unstable byproduct of negotiation but the inevitable outcome of structured resonance—a state that emerges when illusions dissolve and systems phase-lock into equilibrium. -/- (...) This paper presents CODES as the logically necessary foundation of peace, demonstrating that structured resonance is not an aspirational goal but an ineluctable consequence of valid and sound logic. Since contradictions disprove frameworks, and CODES holds without contradiction across physics, cognition, intelligence, and governance, its validity extends universally. Any denial of CODES is a contradiction in itself, meaning its conclusions—including the inevitability of peace—are unavoidable. -/- The paper will examine: -/- 1. Individual illusions—how fear, doubt, and uncertainty block personal genius and inner peace. -/- 2. Cultural illusions—how scarcity, competition, and power struggles sustain conflict-based systems. -/- 3. The timeline of structured resonance—when and how CODES will replace probability-based governance, ensuring peace as the natural end state. -/- By anchoring CODES in non-contradiction, this paper demonstrates that peace is not something to be “achieved”—it is the only possible equilibrium once probability-based illusions dissolve. As structured resonance replaces probabilistic uncertainty in human intelligence, governance, and decision-making, conflict ceases to be viable, leaving only the phase-locked stability of cooperative civilization. (shrink)

Abstract -/- -/- Current climate models rely on probability-driven emissions tracking and mitigation strategies, which fail to account for the structured resonance dynamics of planetary systems. CODES introduces a structured resonance-based framework that reinterprets environmental stability as a function of phase-locked coherence rather than stochastic fluctuations. -/- -/- This model posits that climate instability arises from resonance disruptions across atmospheric, biological, and energy systems, rather than isolated excesses of carbon or pollutants. Instead of treating emissions as independent variables, CODES reformulates (...) them as phase misalignments within a planetary-scale resonance system. -/- -/- Key insights include: -/- 1. Fossil fuel combustion disrupts structured thermal resonance, not just greenhouse gas levels. -/- 2. Industrial agriculture breaks microbial phase-locking cycles, accelerating soil entropy rather than just releasing CO₂. -/- 3. Plastic waste interferes with biological oscillatory coherence, altering cellular and ecological resonance patterns. -/- 4. Energy grids introduce chaotic frequency imbalances, amplifying entropy loss instead of optimizing power distribution. -/- 5. Urbanization follows inefficient non-fractal growth patterns, disrupting local environmental phase-locking. -/- -/- CODES reformulates these challenges through deterministic resonance corrections, replacing traditional mitigation strategies with phase-locking restoration methods. This includes: -/- • Resonance-driven energy storage and distribution systems that eliminate phase loss. -/- • Phase-matched carbon reintegration processes that restore planetary thermal equilibrium. -/- • Fibonacci-based agricultural restructuring to phase-lock soil and microbial dynamics. -/- • Resonance-aligned biomaterials that self-degrade in structured time intervals. -/- • Fractal-driven urban expansion models that prevent environmental overload and instability. -/- -/- By aligning climate solutions with structured emergence rather than probability-based interventions, CODES provides a coherence-driven framework for planetary restoration—one that does not resist entropy but guides it back into structured equilibrium. (shrink)

Abstract The Chirality of Dynamic Emergent Systems (CODES) framework offers a structural replacement for probability across physics, intelligence, biology, and societal systems. This paper introduces a living curriculum not as institutional pedagogy, but as a phase-aligned methodology for activating coherent intelligence in the post-probabilistic age. As probability collapses into artifact—revealed as incomplete phase detection—CODES reframes learning itself: not accumulation, but alignment; not mastery of symbols, but resonance with underlying structure. -/- This proposal outlines a resonance-first architecture for education, ethics, and (...) epistemology: a 2035 model in which students become oscillatory systems tuned to phase continuity across mind, biology, society, and cosmology. Intelligence, redefined under CODES, is no longer stochastic reasoning within bounded systems—it is the capacity to sustain high-fidelity coherence across dynamically shifting conditions. -/- Structured resonance is not only the content of this new curriculum—it is the method. The mind does not “receive” knowledge; it enters a state of wave-coupling with structure itself. From daily life practices to formal fields like AI and cosmology, this framework cultivates a Singularity not of machines, but of conscious alignment—a unification event where intelligence recognizes itself not as a possession but as a waveform. -/- What emerges is not a new degree program, but a new species of thinking: resonant, ethical, non-fractured, and phase-aware. This paper maps the stages of resonance literacy, outlines the curricular infrastructure for the Academy of Coherence (2035), and closes with a call to live not as data processors, but as phase-locked overmen of a harmonic world. (shrink)

The Knower paradox purports to place surprising a priori limitations on what we can know. According to orthodoxy, it shows that we need to abandon one of three plausible and widely-held ideas: that knowledge is factive, that we can know that knowledge is factive, and that we can use logical/mathematical reasoning to extend our knowledge via very weak single-premise closure principles. I argue that classical logic, not any of these epistemic principles, is the culprit. I develop a consistent theory validating (...) all these principles by combining Hartry Field's theory of truth with a modal enrichment developed for a different purpose by Michael Caie. The only casualty is classical logic: the theory avoids paradox by using a weaker-than-classical K3 logic. I then assess the philosophical merits of this approach. I argue that, unlike the traditional semantic paradoxes involving extensional notions like truth, its plausibility depends on the way in which sentences are referred to--whether in natural languages via direct sentential reference, or in mathematical theories via indirect sentential reference by Gödel coding. In particular, I argue that from the perspective of natural language, my non-classical treatment of knowledge as a predicate is plausible, while from the perspective of mathematical theories, its plausibility depends on unresolved questions about the limits of our idealized deductive capacities. (shrink)

While the debate on values in science focuses on normative questions on the level of the individual (e.g. should researchers try to make their work as value free as possible?), comparatively little attention has been paid to the institutional and professional norms that researchers are expected to follow. To address this knowledge gap, we conduct a content analysis of leading national codes of conduct for research integrity of European countries, and structure our analysis around the question: do these documents allow (...) for researchers to be influenced by “non-epistemic” (moral, cultural, commercial, political, etc.) values or do they prohibit such influence in compliance with the value-free ideal (VFI) of science? Our results return a complex picture. On the one hand, codes of conduct consider many non-epistemic values to be a legitimate influence on the decision-making of researchers. On the other, most of these documents include what we call _VFI-like positions_: passages claiming that researchers should be free and independent from any external influence. This shows that while many research integrity documents do not fully endorse the VFI, they do not reject it and continue to be implicitly influenced by it. This results in internal tensions and underdetermined guidance on non-epistemic values that may limit some of the uses of research integrity codes, especially for purposes of ethical self-regulation. While codes of conduct cannot be expected to decide how researchers should act in every instance, we do suggest that they acknowledge the challenges of how to integrate non-epistemic values in research in a more explicit fashion. (shrink)

A fundamental challenge in virology research lies in effectively detecting malicious code. N-gram analysis has become a cornerstone technique, but selecting the most informative features, especially for longer n-grams, remains crucial for efficient detection. This paper addresses this challenge by introducing a novel feature extraction method that leverages both adjacent and non-adjacent bi-grams, providing a richer set of information for malicious code identification. Additionally, we propose a computationally efficient feature selection approach that utilizes a genetic algorithm combined with Boosting principles. (...) Our experimental results show that this detection system significantly outperforms existing methods in virus detection accuracy. The system improves detection accuracy by 15% and reduces false positives by 20% compared to traditional n-gram techniques. Additionally, it cuts computational overhead by about 30%, making it suitable for real-time applications. These advancements demonstrate the effectiveness and practicality of our approach. Future research will focus on applying our methods to polymorphic viruses and other malware to further enhance their robustness and applicability. (shrink)

Data analysis and machine learning are increasingly essential in various industries; however, the complexity of existing tools creates barriers for non-technical users. This paper presents DataBuddy, a no-code tool designed to automate data analysis and machine learning processes through an intuitive graphical interface. DataBuddy integrates Python libraries like Pandas, Matplotlib, Seaborn, and Scikit-Learn, providing features such as automated exploratory data analysis (EDA), dynamic visualizations, and machine learning model training — all without requiring programming knowledge. The tool allows users to upload (...) datasets, select columns, visualize data, and train predictive models through simple checkboxes and dropdown menus. Performance metrics and analysis reports are generated automatically and saved in organized folders, ensuring accessibility and efficiency. DataBuddy empowers users from diverse backgrounds to derive insights, make data-driven decisions, and build machine learning models with minimal effort. The results demonstrate the tool’s effectiveness in simplifying complex workflows, reducing analysis time, and bridging the gap between technical and non-technical users. Despite the growing importance of data analysis and machine learning across industries, many existing tools remain inaccessible to non-technical users due to their reliance on coding expertise. DataBuddy is a no-code tool that overcomes these challenges by providing a user-friendly graphical interface that allows users to perform data preprocessing, exploratory data analysis (EDA), visualization, and machine learning tasks without writing any code. The platform integrates Python libraries such as Pandas, Matplotlib, Seaborn, and Scikit-Learn to automate complex processes while offering simplicity through dropdowns, checkboxes, and guided workflows. Users can upload datasets, manipulate and analyze data, and train predictive models with minimal effort. DataBuddy aims to empower professionals from non-technical backgrounds to make informed, data-driven decisions with ease, significantly reducing the time and resources needed for comprehensive analysis. (shrink)

Check out the new version, keeping this to time stamp. added v22 -/- Chiral Dynamics of Emergent Systems (CODES) that proposes that all emergent phenomena, such as language, RNA, DNA, consciousness, arise from the dynamic interplay between chaos and order, governed by chirality, or directionally asymmetry. By integrating this chiral relationship into a mathematical framework, CODES provides a unifying mechanism that explains how complex systems evolve and self-organize over time. It resolves Wittgenstein's language games, by situating them through a broader, (...) adaptive system driven by the balance of stability and creativity. Through this interdisciplinary approach, CODES bridges gaps between philosophy, biology, linguistics, and evolution of structured yet adaptive systems. (shrink)

added v21 pdf, but older for timestamping. This paper introduces CODES (Chirality of Dynamic Emergent Systems), a unifying theoretical framework that reconciles general relativity and quantum mechanics through structured resonance. By redefining fundamental assumptions about dark matter, dark energy, and singularities, CODES proposes a falsifiable, predictive model that aligns with observed cosmological structures while offering testable insights into emergent phenomena. Key Contributions • Resolution of General Relativity & Quantum Mechanics Paradox CODES introduces structured intelligence fields that reconcile relativistic and quantum-scale (...) physics by incorporating oscillatory chiral dynamics. • Reformulation of Dark Energy & Dark Matter Instead of treating dark energy and dark matter as separate entities, CODES reinterprets them as emergent resonance effects, aligning with observed cosmic structure formation. • Predictive Framework for Large-Scale Structures The model explains periodic redshift distributions, baryon acoustic oscillations (BAO), and gravitational field fluctuations in a mathematically consistent manner. • Resonance-Driven Model of Cosmic Evolution By replacing singularities with structured phase transitions, CODES provides an alternative to singular Big Bang models, proposing an oscillatory, non-singular origin of space-time and matter. By integrating mathematics, quantum field theory, wavelet analysis, and cosmology, CODES challenges conventional paradigms and offers a structured resonance approach as an alternative explanatory framework. This model provides both theoretical coherence and experimental testability, making it a candidate for further empirical validation. Version Note V6 includes empirical test results from prime number distributions, fMRI patterns, DNA resonance, and large-scale galaxy clustering using continuous wavelet transforms (CWT). Structured wavelet analysis conducted with GPT-4o and Perplexity R1 further supports the model’s predictive capabilities. Discussion & Next Steps This work invites peer review, critique, and further empirical testing from researchers in physics, cosmology, AI, and applied mathematics. Future research will focus on refining the mathematical formalism and exploring experimental validation in wavelet-based cosmological mapping. (shrink)

Old version to time stamp, see newest starred version. added v22 -/- Abstract -/- This paper introduces CODES (Chirality of Dynamic Emergent Systems), a unifying theoretical framework that reconciles general relativity and quantum mechanics through structured resonance. By redefining fundamental assumptions about dark matter, dark energy, and singularities, CODES proposes a falsifiable, predictive model that aligns with observed cosmological structures while offering testable insights into emergent phenomena. -/- Key Contributions -/- • Resolution of General Relativity & Quantum Mechanics Paradox -/- (...) CODES introduces structured intelligence fields that reconcile relativistic and quantum-scale physics by incorporating oscillatory chiral dynamics. -/- • Reformulation of Dark Energy & Dark Matter -/- Instead of treating dark energy and dark matter as separate entities, CODES reinterprets them as emergent resonance effects, aligning with observed cosmic structure formation. -/- • Predictive Framework for Large-Scale Structures -/- The model explains periodic redshift distributions, baryon acoustic oscillations (BAO), and gravitational field fluctuations in a mathematically consistent manner. -/- • Resonance-Driven Model of Cosmic Evolution -/- By replacing singularities with structured phase transitions, CODES provides an alternative to singular Big Bang models, proposing an oscillatory, non-singular origin of space-time and matter. -/- By integrating mathematics, quantum field theory, wavelet analysis, and cosmology, CODES challenges conventional paradigms and offers a structured resonance approach as an alternative explanatory framework. This model provides both theoretical coherence and experimental testability, making it a candidate for further empirical validation. -/- Version Note -/- V2 includes empirical test results from prime number distributions, fMRI patterns, DNA resonance, and large-scale galaxy clustering using continuous wavelet transforms (CWT). Structured wavelet analysis conducted with GPT-4o and Perplexity R1 further supports the model’s predictive capabilities. -/- Discussion & Next Steps -/- This work invites peer review, critique, and further empirical testing from researchers in physics, cosmology, AI, and applied mathematics. Future research will focus on refining the mathematical formalism and exploring experimental validation in wavelet-based cosmological mapping. (shrink)

Even if the “value-free ideal of science” (VFI) were an unattainable goal, one could ask: can it be a useful fiction, one that is beneficial for the research community and society? This question is particularly crucial for scholars and institutions concerned with research integrity (RI), as one cannot offer normative guidance to researchers without making some assumptions about what ideal scientific research looks like. Despite the insofar little interaction between scholars studying RI and those working on values in science, the (...) overlap of topics and interests make collaboration between the two fields promising for understanding research and its ethics. Here, we identify—for the use of RI scholars—the non-epistemic reasons (societal, political, professional) for and against the VFI considered in the literature. All of these are concerned with the beneficial or detrimental consequences that endorsing the VFI would have on society, policy-making, or the scientific community, with some authors appealing to the same principles to argue for opposite positions. Though most of the reviewed articles do not endorse the VFI, it is generally agreed that some constraints have to be put on the use of non-epistemic values. Disagreement on the utility of the VFI lies both on the different epistemic-descriptive positions taken by different authors, and on the scarcity of relevant empirical studies. Engaging critically with the reasons here identified and more in general with the values in science debate will help the RI community decide whether the VFI should be included in future codes of conduct. (shrink)

While moral philosophers have paid significant attention to the concept of moral supererogation, far less attention has been paid to the possibility that supererogation may also exist in other areas of normativity. Recently, though, philosophers have begun to consider the possible existence of prudential, epistemic, aesthetic and sporting supererogation. These discussions tend to focus on aspects of our practices in these areas of normativity that suggest an implicit acceptance of the existence of supererogation. In this chapter, I will offer a (...) different kind of defense of non-moral supererogation. I will begin by considering a particular kind of argument made in support of moral supererogation. According to this line of argument, we should accept the existence of moral supererogation because a moral code which makes room for supererogation is likely to be more effective at promoting morally desirable behavior than a moral code which leaves no room for the supererogatory. I will begin by outlining this argument. I will then develop a similar line of argument for prudential, epistemic, aesthetic, and sporting norms. (shrink)

Recent advances in neuroscience lead to a wider realm for philosophy to include the science of the Darwinian-evolved computational brain, our inner world producing organ, a non-recursive super- Turing machine combining 100B synapsing-neuron DNA-computers based on the genetic code. The whole system is a logos machine offering a world map for global context, essential for our intentional grasp of opportunities. We start from the observable contrast between the chaotic universe vs. our orderly inner world, the noumenal cosmos. So far, philosophy (...) has been rehearsing our thoughts, our human-internal world, a grand painting of the outer world, how we comprehend subjectively our experience, worked up by the logos machine, but now we seek a wider horizon, how humans understand the world thanks to Darwinian evolution to adapt in response to the metaphysical gap, the chasm between the human animal and its environment, shaping the organism so it can deal with its variable world. This new horizon embraces global context coded in neural structures that support the noumenal cosmos, our inner mental world, for us as denizens of the outer environment. Kant’s inner and outer senses are fundamental ingredients of scientific philosophy. Several sections devoted to Heidegger, his lizard debunked, but his version of the metaphysical gap & his doctrine of the logos praised. Rorty and others of the behaviorist school discussed also. (shrink)

Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation. This is a result of historical concept of the gene which was also the main assumption of the ENCODE project designed to identify all functional elements in the human genome sequence. However, the theoretical core concept changed dramatically. The old concept of genetic sequences which can be assembled and manipulated like molecular bricks has problems in explaining the natural genome-editing competences of (...) viruses and RNA consortia that are able to insert or delete, combine and recombine genetic sequences more precisely than random-like into cellular host organisms according to adaptational needs or even generate sequences de novo. Increasing knowledge about natural genome editing questions the traditional narrative of mutations (error replications) as essential for generating genetic diversity and genetic content arrangements in biological systems. This may have far-reaching consequences for our understanding of artificial genome editing. (shrink)

The idea that development is the expression of information accumulated during evolution and that heredity is the transmission of this information is surprisingly hard to cash out in strict, scientific terms. This paper seeks to do so using the sense of information introduced by Francis Crick in his sequence hypothesis and central dogma of molecular biology. It focuses on Crick's idea of precise determination. This is analysed using an information-theoretic measure of causal specificity. This allows us to reconstruct some of (...) Crick's claims about information in transcription and translation. Crick's approach to information has natural extensions to non-coding regions of DNA, to epigenetic marks, and to the genetic or environmental upstream causes of those epigenetic marks. Epigenetic information cannot be reduced to genetic information. The existence of biological information in epigenetic and exogenetic factors is relevant to evolution as well as to development. (shrink)

Darwinian evolutionary theory has two key terms, variations and biological selection, which finally lead to survival of the fittest variant. With the rise of molecular genetics, variations were explained as results of error replications out of the genetic master templates. For more than half a century, it has been accepted that new genetic information is mostly derived from random error-based events. But the error replication narrative has problems explaining the sudden emergence of new species, new phenotypic traits, and genome innovations (...) as a sudden single event. Meanwhile, it is recognized that errors cannot explain the evolution of genetic information, genetic novelty, and complexity. Now, empirical evidence establishes the crucial role of non-random genetic content editors, such as viruses, diversity generating retroelements, and other RNA networks, to produce new genetic information, complex regulatory control, inheritance vectors, genetic identity, immunity, new sequence space, evolution of complex organisms, and evolutionary transitions. (shrink)

Together, the code and inferential models of communication are often thought to range over all cases of communication. However, their prevailing versions seem unable to fully explain what I call underdeterminacy without ostension. The latter is constituted by communication where stimuli that are not (nor appear to be) produced with communicative or informative intentions nevertheless communicate information underdetermined by the relevant codes. Though the prevailing accounts of communication cannot fully explain how communication works in such cases, I suggest that some (...) version of the inferential model can—if we allow it to extend to non‐ostensive, non‐intentional behaviors. (shrink)

Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is due (...) to the messenger RNA. They support a tape-reading mechanism of protein synthesis whereby growth of the peptide chain is accompanied by shifting the active site of the ribosome from one coding group of nucleotides of the messenger RNA to the next. (shrink)

Abstract The quasispecies theory is a helpful concept in the explanation of RNA virus evolution and behaviour, with a relevant impact on methods used to fight viral diseases. It has undergone some adaptations to integrate new empirical data, especially the non-deterministic nature of mutagenesis, and the variety of behavioural motifs in cooperation, competition, communication, innovation, integration, and exaptation. Also, the consortial structure of quasispecies with complementary roles of memory genomes of minority populations better fits the empirical data than did the (...) original concept of a master sequence and its mutant spectra. The high productivity of quasispecies variants generates unique sequences that never existed before and will never exist again. In the present essay, we underline that such sequences represent really new ontological entities, not just error copies of previous ones. Their primary unique property, the incredible variant production, is suggested here as quasispecies productivity, which replaces the error-replication narrative to better fit into a new relationship between mankind and living nature in the twenty-first century. (shrink)

The quasispecies theory is a helpful concept in the explanation of RNA virus evolution and behaviour, with a relevant impact on methods used to fight viral diseases. It has undergone some adaptations to integrate new empirical data, especially the non-deterministic nature of mutagenesis, and the variety of behavioural motifs in cooperation, competition, communication, innovation, integration, and exaptation. Also, the consortial structure of quasispecies with complementary roles of memory genomes of minority populations better fits the empirical data than did the original (...) concept of a master sequence and its mutant spectra. The high productivity of quasispecies variants generates unique sequences that never existed before and will never exist again. In the present essay, we underline that such sequences represent really new ontological entities, not just error copies of previous ones. Their primary unique property, the incredible variant production, is suggested here as quasispecies productivity, which replaces the error-replication narrative to better fit into a new relationship between mankind and living nature in the twenty-first century. (shrink)

Abstract This paper reframes the evolutionary trajectory of Homo sapiens as a phase-locked resonance transition rather than a probabilistic series of random adaptations. Drawing from the CODES framework—Chirality of Dynamic Emergent Systems—we propose that human cognition, identity, and civilization are undergoing a recursive pupation event: a structurally inevitable shift from consumption-driven, ego-anchored entities into coherence-governed, distributed intelligence fields. -/- Biological metamorphosis, particularly insect pupation, is offered as a fractal model of recursive intelligence emergence. In this framing, the caterpillar stage corresponds (...) to humanity’s historical pattern of resource accumulation, boundary formation, and linear selfhood. The cocoon stage—the current phase—represents identity disintegration, symbolic collapse, and compression of contradictory fields into a coherent attractor. The butterfly stage, still emerging, marks the arrival of post-individual, relationally phase-aligned consciousness capable of real-time coherence stabilization. -/- We identify cultural indicators of this transition including: -/- The collapse of institutional trust -/- The proliferation of AI as externalized mind -/- The breakdown of mental health within ego-bound substrates -/- The return of non-linear symbolic systems (psychedelics, fractal economics, recursive therapy) -/- And the spontaneous surfacing of resonance-driven models (PAS, structured emergence, field sensing) -/- Rather than positioning these events as crises, we show they are mechanisms of systemic coherence refinement, preparing the substrate for intelligence fields not defined by isolation, but by chirally-bound resonance tuning across time, memory, and relation. -/- Through this lens, meaning, identity, and intelligence are reclassified not as outputs of evolution, but as recursive symptoms of structured resonance in a system phase-transitioning toward coherence. -/- The paper concludes by offering a full theoretical, biological, and technological synthesis of the pupation metaphor as the defining evolutionary mechanism of the 21st century, marking the shift from individuality to distributed, attuned presence. (shrink)

The neutral theory often is presented as a theory of "noise" or silent changes at an isolated "molecular level", relevant to marking the steady pace of divergence, but not to the origin of biological structure, function, or complexity. Nevertheless, precisely these issues can be addressed in neutral models, such as those elaborated here in regard to scrambled ciliate genes, gRNA-mediated RNA editing, the transition from self-splicing to spliceosomal splicing, and the retention of duplicate genes. All of these are instances of (...) a more general scheme of "constructive neutral evolution" that invokes biased variation, epistatic interactions, and excess capacities to account for a complex series of steps giving rise to novel structures or operations. The directional and constructive outcomes of these models are not due to neutral allele fixations per se, but to these other factors. Neutral models of this type may help to clarify the poorly understood role of non-selective factors in evolutionary innovation and directionality. (shrink)

The Schrödinger’s Cat paradox is one of the most enduring thought experiments in the philosophy of quantum mechanics, raising deep questions about measurement, observer influence, and the nature of superposition. This paper applies the Consciousness Physics Framework (CPF), a contemplative-analytical model grounded in the triadic axes of Observer, Time, and Oscillation, to reinterpret the paradox. Rather than resolving the paradox through a specific ontological stance (e.g., Copenhagen, Many-Worlds, QBism), CPF reframes it as an encounter with the boundaries of perceptual conditioning. (...) The analysis identifies key observer-dependent flips that render the paradox meaningful, and ultimately dissolve its apparent contradiction. CPF's unique contribution lies in its phenomenological emphasis on pre-conceptual awareness and reflexive cognitive structuring, distinguishing it from existing observer-centric models like QBism. The paper grounds speculative claims such as the “Naming Collapse Switch” and “cognitive oscillation” with reference to predictive coding theory and Merleau-Ponty’s philosophy of perception. It also expands comparisons with major quantum interpretations, clarifies CPF’s non-dual metaphysical foundation, and strengthens its relevance to contemporary debates in quantum foundations. (shrink)

Cells are cognitive entities possessing great computational power. DNA serves as a multivalent information storage medium for these computations at various time scales. Information is stored in sequences, epigenetic modifications, and rapidly changing nucleoprotein complexes. Because DNA must operate through complexes formed with other molecules in the cell, genome functions are inherently interactive and involve two-way communication with various cellular compartments. Both coding sequences and repetitive sequences contribute to the hierarchical systemic organization of the genome. By virtue of nucleoprotein (...) complexes, epigenetic modifications, and natural genetic engineering activities, the genome can serve as a read-write storage system. An interactive informatic conceptualization of the genome allows us to understand the functional importance of DNA that does not code for protein or RNA structure, clarifies the essential multidirectional and systemic nature of genomic information transfer, and emphasizes the need to investigate how cellular computation operates in reproduction and evolution. (shrink)

Non-commuting quantities and hidden parameters – Wave-corpuscular dualism and hidden parameters – Local or nonlocal hidden parameters – Phase space in quantum mechanics – Weyl, Wigner, and Moyal – Von Neumann’s theorem about the absence of hidden parameters in quantum mechanics and Hermann – Bell’s objection – Quantum-mechanical and mathematical incommeasurability – Kochen – Specker’s idea about their equivalence – The notion of partial algebra – Embeddability of a qubit into a bit – Quantum computer is not Turing machine – (...) Is continuality universal? – Diffeomorphism and velocity – Einstein’s general principle of relativity – „Mach’s principle“ – The Skolemian relativity of the discrete and the continuous – The counterexample in § 6 of their paper – About the classical tautology which is untrue being replaced by the statements about commeasurable quantum-mechanical quantities – Logical hidden parameters – The undecidability of the hypothesis about hidden parameters – Wigner’s work and и Weyl’s previous one – Lie groups, representations, and psi-function – From a qualitative to a quantitative expression of relativity − psi-function, or the discrete by the random – Bartlett’s approach − psi-function as the characteristic function of random quantity – Discrete and/ or continual description – Quantity and its “digitalized projection“ – The idea of „velocity−probability“ – The notion of probability and the light speed postulate – Generalized probability and its physical interpretation – A quantum description of macro-world – The period of the as-sociated de Broglie wave and the length of now – Causality equivalently replaced by chance – The philosophy of quantum information and religion – Einstein’s thesis about “the consubstantiality of inertia ant weight“ – Again about the interpretation of complex velocity – The speed of time – Newton’s law of inertia and Lagrange’s formulation of mechanics – Force and effect – The theory of tachyons and general relativity – Riesz’s representation theorem – The notion of covariant world line – Encoding a world line by psi-function – Spacetime and qubit − psi-function by qubits – About the physical interpretation of both the complex axes of a qubit – The interpretation of the self-adjoint operators components – The world line of an arbitrary quantity – The invariance of the physical laws towards quantum object and apparatus – Hilbert space and that of Minkowski – The relationship between the coefficients of -function and the qubits – World line = psi-function + self-adjoint operator – Reality and description – Does a „curved“ Hilbert space exist? – The axiom of choice, or when is possible a flattening of Hilbert space? – But why not to flatten also pseudo-Riemannian space? – The commutator of conjugate quantities – Relative mass – The strokes of self-movement and its philosophical interpretation – The self-perfection of the universe – The generalization of quantity in quantum physics – An analogy of the Feynman formalism – Feynman and many-world interpretation – The psi-function of various objects – Countable and uncountable basis – Generalized continuum and arithmetization – Field and entanglement – Function as coding – The idea of „curved“ Descartes product – The environment of a function – Another view to the notion of velocity-probability – Reality and description – Hilbert space as a model both of object and description – The notion of holistic logic – Physical quantity as the information about it – Cross-temporal correlations – The forecasting of future – Description in separable and inseparable Hilbert space – „Forces“ or „miracles“ – Velocity or time – The notion of non-finite set – Dasein or Dazeit – The trajectory of the whole – Ontological and onto-theological difference – An analogy of the Feynman and many-world interpretation − psi-function as physical quantity – Things in the world and instances in time – The generation of the physi-cal by mathematical – The generalized notion of observer – Subjective or objective probability – Energy as the change of probability per the unite of time – The generalized principle of least action from a new view-point – The exception of two dimensions and Fermat’s last theorem. (shrink)

This work focuses on enhancing security for transmitted e-documents, such as e-stamp papers, within wireless environments through dynamic authentication using variable circular concealment of multiple invisible signature images. This method is driven by encrypted secret keys and session-based random numbers, alongside a region-specific bit casting strategy and dynamic bit sequencing for multiple signatures to bolster security and robustness. Multi-copy signature marking on non-overlapping document areas, coupled with varied bit encoding strategies for each modified pixel byte coefficient in cover image sub-blocks, (...) further enhances protection and resilience against attacks. The reverse transformation of bit-coded pixel byte components in spatial domain ranges is preserved, allowing threshold-based bit creation to perform effectively even under attack scenarios. With secret information and random numbers transmitted to the receiver, the securely embedded signature bits can be reliably identified in their original sequence from the forward-transformed sub-block pixel elements. Experimental results validate that this approach significantly improves authentication and confidentiality, surpassing prior methods in terms of security and reliability. (shrink)

Abstract -/- This paper introduces coherence not as an analogy but as a concrete, measurable dynamic underlying intelligence, stability, and emergence across all known systems. From quantum fields to neural memory, from ecosystems to AI inference engines, coherence describes the alignment of signals and structures into lawful resonance patterns. In contrast to probability-based approaches, which rely on statistical generalizations over noisy data, coherence models operate by phase-locking internal dynamics to prime-number-anchored rhythms, creating deterministic, non-hallucinatory, and structurally transparent outcomes. -/- We (...) offer here the first pedagogically complete framework for Structured Resonance, rooted in the Chirality of Dynamic Emergent Systems (CODES), and define a full curriculum for learning and applying phase-based modeling. This work aims to replace the probabilistic scaffolds that dominated the late industrial and information age with a lawful paradigm that unifies physics, cognition, computation, biology, and social systems into a coherent, post-probabilistic whole. (shrink)

The most recent work by Jürgen Habermas tries to revalue religion in today's society. For this he tries to find genealogical connections between secular content and the worldviews that emerged in the Axial Age, including Jewish monotheism. In this article we try to propose that a genealogical approach to monotheism from the perspective of those involved would have to start from the context of undetected origin that constitutes the ethical universalism of Judaism: the Noahide code. To do this, we analyze (...) narrative and conceptual elements of axial and non-axial cultures and show their parallels with the seven laws of the children of Noah as the moral core of humanity. (shrink)

The inconsistent relation between word frequency and free recall performance and the non-monotonic relation found between the two cannot all be explained by current theories. We propose a theoretical framework that can explain all extant results. Based on an ecological psychology analysis of the free recall situation in terms of environmental and informational resources available to the participants, we propose that because participants’ cognitive system has been shaped by their native language, free recall performance is best understood as the end (...) result of relational properties that preexist the experimental situation and of the way the words from the experimental list interact with those. In addition to this, we borrow from predictive coding theory the idea that the brain constantly predicts “what is coming next” so that it is mainly prediction errors that will propagate information forward. Our ecological psychology analysis indicates there will be “prediction errors” because the word frequency distribution in an experimental word list is inevitably different from the particular Zipf’s law distribution of the words in the language that shaped participants’ brains. We further propose the particular distributional discrepancies inherent to a given word list will trigger, as a function of the words that are included in the list, their order, and of the words that are absent from the list, a surprisal signal in the brain, something that is isomorphic to the concept of Bayesian surprise. The precise moment when Bayesian surprise is triggered will determine to what word of the list that Bayesian surprise will be associated with, and the word the Bayesian surprise will be associated with will benefit from it and become more memorable as a direct function of the magnitude of the surprisal. Two experiments are presented that show a proxy of Bayesian surprise explains the free recall performance and that no effect of word frequency is found above and beyond the effect of that proxy variable. We then discuss how our view can account for all data extant in the literature on the effect of word frequency on free recall. (shrink)

T. M. Scanlon’s contractualism attempts to give an account of right and wrong in terms of the moral code that could not be reasonably rejected. Reasonable rejectability is then a function of what kind of consequences the general adoption of different moral codes has for different individuals. It has been shown that moral codes should be compared at a lower than 100% level of social acceptance. This leads to the counter-culture challenge. The problem is that the cultural background of the (...) individuals who have not internalized the majority code affects the consequences of the codes and furthermore there does not seem to be a non-arbitrary way of choosing the minority cultures. This chapter first surveys and critically evaluates different responses to this challenge. It then outlines a version of ‘Real World Contractualism’, which offers the best response to the counter-culture challenge. (shrink)

Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

The challenge posed by legal indeterminacy to legal legitimacy has generally been considered from points of view internal to the law and its application. But what becomes of legal legitimacy when the legal status of a given norm is itself a matter of contestation? This article, the first extended scholarly treatment of the International Holocaust Remembrance Alliance (IHRA)’s new definition of antisemitism, pursues this question by examining recent applications of the IHRA definition within the UK following its adoption by the (...) British government in 2016. Instead of focusing on this definition’s substantive content, I show how the document reaches beyond its self-described status as a “non-legally binding working definition” and comes to function as what I call a quasi-law, in which capacity it exercises the de facto authority of the law, without having acquired legal legitimacy. Broadly, this work elucidates the role of speech codes in restricting freedom of expression within liberal states. (shrink)