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  1. Who is a Modeler?Michael Weisberg - 2007 - British Journal for the Philosophy of Science 58 (2):207-233.
    Many standard philosophical accounts of scientific practice fail to distinguish between modeling and other types of theory construction. This failure is unfortunate because there are important contrasts among the goals, procedures, and representations employed by modelers and other kinds of theorists. We can see some of these differences intuitively when we reflect on the methods of theorists such as Vito Volterra and Linus Pauling on the one hand, and Charles Darwin and Dimitri Mendeleev on the other. Much of Volterra's and (...)
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  • Understanding scientific progress: the noetic account.Finnur Dellsén - 2021 - Synthese 199 (3-4):11249-11278.
    What is scientific progress? This paper advances an interpretation of this question, and an account that serves to answer it. Roughly, the question is here understood to concern what type of cognitive change with respect to a topic X constitutes a scientific improvement with respect to X. The answer explored in the paper is that the requisite type of cognitive change occurs when scientific results are made publicly available so as to make it possible for anyone to increase their understanding (...)
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  • Exploratory hypothesis tests can be more compelling than confirmatory hypothesis tests.Mark Rubin & Chris Donkin - 2024 - Philosophical Psychology 37 (8):2019-2047.
    Preregistration has been proposed as a useful method for making a publicly verifiable distinction between confirmatory hypothesis tests, which involve planned tests of ante hoc hypotheses, and exploratory hypothesis tests, which involve unplanned tests of post hoc hypotheses. This distinction is thought to be important because it has been proposed that confirmatory hypothesis tests provide more compelling results (less uncertain, less tentative, less open to bias) than exploratory hypothesis tests. In this article, we challenge this proposition and argue that there (...)
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  • State of the Field: Why novel prediction matters.Heather Douglas & P. D. Magnus - 2013 - Studies in History and Philosophy of Science Part A 44 (4):580-589.
    There is considerable disagreement about the epistemic value of novel predictive success, i.e. when a scientist predicts an unexpected phenomenon, experiments are conducted, and the prediction proves to be accurate. We survey the field on this question, noting both fully articulated views such as weak and strong predictivism, and more nascent views, such as pluralist reasons for the instrumental value of prediction. By examining the various reasons offered for the value of prediction across a range of inferential contexts , we (...)
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  • Novel Predictions and the No Miracle Argument.Mario Alai - 2014 - Erkenntnis 79 (2):297-326.
    Predictivists use the no miracle argument to argue that “novel” predictions are decisive evidence for theories, while mere accommodation of “old” data cannot confirm to a significant degree. But deductivists claim that since confirmation is a logical theory-data relationship, predicted data cannot confirm more than merely deduced data, and cite historical cases in which known data confirmed theories quite strongly. On the other hand, the advantage of prediction over accommodation is needed by scientific realists to resist Laudan’s criticisms of the (...)
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  • On the predilections for predictions.David Harker - 2008 - British Journal for the Philosophy of Science 59 (3):429-453.
    Scientific theories are developed in response to a certain set of phenomena and subsequently evaluated, at least partially, in terms of the quality of fit between those same theories and appropriately distinctive phenomena. To differentiate between these two stages it is popular to describe the former as involving the accommodation of data and the latter as involving the prediction of data. Predictivism is the view that, ceteris paribus, correctly predicting data confers greater confirmation than successfully accommodating data. In this paper, (...)
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  • Prediction and accommodation revisited.John Worrall - 2014 - Studies in History and Philosophy of Science Part A 45 (1):54-61.
    The paper presents a further articulation and defence of the view on prediction and accommodation that I have proposed earlier. It operates by analysing two accounts of the issue-by Patrick Maher and by Marc Lange-that, at least at first sight, appear to be rivals to my own. Maher claims that the time-order of theory and evidence may be important in terms of degree of confirmation, while that claim is explicitly denied in my account. I argue, however, that when his account (...)
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  • The atomic number revolution in chemistry: a Kuhnian analysis.K. Brad Wray - 2017 - Foundations of Chemistry 20 (3):209-217.
    This paper argues that the field of chemistry underwent a significant change of theory in the early twentieth century, when atomic number replaced atomic weight as the principle for ordering and identifying the chemical elements. It is a classic case of a Kuhnian revolution. In the process of addressing anomalies, chemists who were trained to see elements as defined by their atomic weight discovered that their theoretical assumptions were impediments to understanding the chemical world. The only way to normalize the (...)
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  • Novelty, coherence, and Mendeleev’s periodic table.Samuel Schindler - 2014 - Studies in History and Philosophy of Science Part A 45:62-69.
    Predictivism is the view that successful predictions of “novel” evidence carry more confirmational weight than accommodations of already known evidence. Novelty, in this context, has traditionally been conceived of as temporal novelty. However temporal predictivism has been criticized for lacking a rationale: why should the time order of theory and evidence matter? Instead, it has been proposed, novelty should be construed in terms of use-novelty, according to which evidence is novel if it was not used in the construction of a (...)
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  • Prediction and the 'periodic law': a rejoinder to Barnes.John Worrall - 2005 - Studies in History and Philosophy of Science Part A 36 (4):817-826.
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  • A coherentist conception of ad hoc hypotheses.Samuel Schindler - 2018 - Studies in History and Philosophy of Science Part A 67:54-64.
    What does it mean for a hypothesis to be ad hoc? One prominent account has it that ad hoc hypotheses have no independent empirical support. Others have viewed ad hoc judgements as subjective. Here I critically review both of these views and defend my own Coherentist Conception of Ad hocness by working out its conceptual and descriptive attractions.
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  • Causal explanation and the periodic table.Lauren N. Ross - 2018 - Synthese 198 (1):79-103.
    The periodic table represents and organizes all known chemical elements on the basis of their properties. While the importance of this table in chemistry is uncontroversial, the role that it plays in scientific reasoning remains heavily disputed. Many philosophers deny the explanatory role of the table and insist that it is “merely” classificatory (Shapere, in F. Suppe (Ed.) The structure of scientific theories, University of Illinois Press, Illinois, 1977; Scerri in Erkenntnis 47:229–243, 1997). In particular, it has been claimed that (...)
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  • Are laws of nature and scientific theories peculiar in chemistry? Scrutinizing mendeleev's discovery.R. Vihalemm - 2003 - Foundations of Chemistry 5 (1):7-22.
    The problem of the peculiarcharacter of chemical laws and theories is a central topic in philosophy of chemistry. Oneof the most characteristic and, at the sametime, most puzzling examples in discussions onchemical laws and theories is Mendeleev''speriodic law. This law seems to be essentiallydifferent in its nature from the exact laws ofclassical physics, the latter being usuallyregarded as a paradigm of science byphilosophers. In this paper the main argumentsconcerning the peculiar character of chemicallaws and theories are examined. The laws ofchemistry (...)
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  • Thermodynamic foundations of physical chemistry: reversible processes and thermal equilibrium into the history.Raffaele Pisano, Abdelkader Anakkar, Emilio Marco Pellegrino & Maxime Nagels - 2018 - Foundations of Chemistry 21 (3):297-323.
    In the history of science, the birth of classical chemistry and thermodynamics produced an anomaly within Newtonian mechanical paradigm: force and acceleration were no longer citizens of new cited sciences. Scholars tried to reintroduce them within mechanistic approaches, as the case of the kinetic gas theory. Nevertheless, Thermodynamics, in general, and its Second Law, in particular, gradually affirmed their role of dominant not-reducible cognitive paradigms for various scientific disciplines: more than twenty formulations of Second Law—a sort of indisputable intellectual wealth—are (...)
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  • Predictivism and model selection.Alireza Fatollahi - 2023 - European Journal for Philosophy of Science 13 (1):1-28.
    There has been a lively debate in the philosophy of science over _predictivism_: the thesis that successfully predicting a given body of data provides stronger evidence for a theory than merely accommodating the same body of data. I argue for a very strong version of the thesis using statistical results on the so-called “model selection” problem. This is the problem of finding the optimal model (family of hypotheses) given a body of data. The key idea that I will borrow from (...)
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  • On Mendeleev’s predictions: comment on Scerri and Worrall.Eric Barnes - 2005 - Studies in History and Philosophy of Science Part A 36 (4):801-812.
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  • An Epistemic Advantage of Accommodation over Prediction.Finnur Dellsén - forthcoming - Philosophers' Imprint.
    Many philosophers have argued that a hypothesis is better confirmed by some data if the hypothesis was not specifically designed to fit the data. ‘Prediction’, they argue, is superior to ‘accommodation’. Others deny that there is any epistemic advantage to prediction, and conclude that prediction and accommodation are epistemically on a par. This paper argues that there is a respect in which accommodation is superior to prediction. Specifically, the information that the data was accommodated rather than predicted suggests that the (...)
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  • Theoretical fertility McMullin-style.Samuel Schindler - 2017 - European Journal for Philosophy of Science 7 (1):151-173.
    A theory’s fertility is one of the standard theoretical virtues. But how is it to be construed? In current philosophical discourse, particularly in the realism debate, theoretical fertility is usually understood in terms of novel success: a theory is fertile if it manages to make successful novel predictions. Another, more permissible, notion of fertility can be found in the work of Ernan McMullin. This kind of fertility, McMullin claims, gives us just as strong grounds for realism. My paper critically assesses (...)
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  • The big test of corroboration.Darrell Patrick Rowbottom - 2008 - International Studies in the Philosophy of Science 22 (3):293 – 302.
    This paper presents a new 'discontinuous' view of Popper's theory of corroboration, where theories cease to have corroboration values when new severe tests are devised which have not yet been performed, on the basis of a passage from The Logic of Scientific Discovery. Through subsequent analysis and discussion, a novel problem for Popper's account of corroboration, which holds also for the standard view, emerges. This is the problem of the Big Test : that the severest test of any hypothesis is (...)
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  • Use-novel predictions and Mendeleev’s periodic table: response to Scerri and Worrall.Samuel Schindler - 2008 - Studies in History and Philosophy of Science Part A 39 (2):265-269.
    In this paper I comment on a recent paper by [Scerri, E., & Worrall, J. . Prediction and the periodic table. Studies in History and Philosophy of Science, 32, 407–452.] about the role temporally novel and use-novel predictions played in the acceptance of Mendeleev’s periodic table after the proposal of the latter in 1869. Scerri and Worrall allege that whereas temporally novel predictions—despite Brush’s earlier claim to the contrary—did not carry any special epistemic weight, use-novel predictions did indeed contribute to (...)
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  • Values and periodicity: Mendeleev's reception of the equations of Mills, Chicherin, and Vincent.Karoliina Pulkkinen - 2019 - Centaurus 61 (4):405-423.
    This article focuses on the Russian chemist Dmitri Ivanovich Mendeleev's assessment of certain representations of various aspects of the periodic system that employed more mathematical methodology. The equations of interest were created by E. J. Mills, B. N. Chicherin, and J. H. Vincent. The English chemist Mills tried to find a firmer numerical basis for the periodicity of the elements. The Russian lawyer and political philosopher Chicherin was convinced of the existence of a mathematical law underlying the periodic system. The (...)
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  • Reifying mathematics? Prediction and symmetry classification.Sorin Bangu - 2008 - Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics 39 (2):239-258.
    In this paper I reconstruct and critically examine the reasoning leading to the famous prediction of the ‘omega minus’ particle by M. Gell-Mann and Y. Ne’eman (in 1962) on the basis of a symmetry classification scheme. While the peculiarity of this prediction has occasionally been noticed in the literature, a detailed treatment of the methodological problems it poses has not been offered yet. By spelling out the characteristics of this type of prediction, I aim to underscore the challenges raised by (...)
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  • Response to Barnes’s critique of Scerri and Worral.Eric R. Scerri - 2005 - Studies in History and Philosophy of Science Part A 36 (4):813-816.
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  • An appraisal of Mendeleev’s contribution to the development of the periodic table.Mansoor Niaz, María A. Rodríguez & Angmary Brito - 2004 - Studies in History and Philosophy of Science Part A 35 (2):271-282.
    Historians and philosophers of science generally conceptualize scientific progress to be dichotomous, viz., experimental observations lead to scientific laws, which later facilitate the elaboration of explanatory theories. There is considerable controversy in the literature with respect to Mendeleev’s contribution to the origin, nature, and development of the periodic table. The objectives of this study are to explore and reconstruct: a) periodicity in the periodic table as a function of atomic theory; b) role of predictions in scientific theories and its implications (...)
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  • Scientific discovery: that-what’s and what-that’s.Samuel Schindler - 2015 - Ergo: An Open Access Journal of Philosophy 2.
    In this paper I defend Kuhn’s view of scientific discovery, which involves two central tenets, namely that a scientific discovery always requires a discovery-that and a discovery-what, and that there are two kinds of scientific discovery, resulting from the temporal order of the discovery-that and the discovery-what. I identify two problems with Kuhn’s account and offer solutions to them from a realist stance. Alternatives to Kuhn’s account are also discussed.
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  • What’s Really at Issue with Novel Predictions?Robert G. Hudson - 2007 - Synthese 155 (1):1-20.
    In this paper I distinguish two kinds of predictivism, 'timeless' and 'historicized'. The former is the conventional understanding of predictivism. However, I argue that its defense in the works of John Worrall and Patrick Maher is wanting. Alternatively, I promote an historicized predictivism, and briefly defend such a predictivism at the end of the paper.
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  • Accomodation, prediction, and confirmation.Lee McIntyre - 2001 - Perspectives on Science 9 (3):308-323.
    : In this paper I argue that belief in the greater confirmatory value of prediction over accommodation can best be understood as a function of the practice rather than the logic of science. Attempts to account for this asymmetry within the logic of science have revealed no non-arbitrary way to address the problem of underdetermination as it applies to prediction and thus have failed to account for the preference for prediction over accommodation on logical grounds. Instead, I propose a model (...)
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  • Predictivism and the periodic table.Stephen G. Brush - 2007 - Studies in History and Philosophy of Science Part A 38 (1):256-259.
    This is a comment on the paper by Barnes and the responses from Scerri and Worrall, debating the thesis that a fact successfully predicted by a theory is stronger evidence than a similar fact known before the prediction was made. Since Barnes and Scerri both use evidence presented in my paper on Mendeleev’s periodic law to support their views, I reiterate my own position on predictivism. I do not argue for or against predictivism in the normative sense that philosophers of (...)
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  • Predictivism for pluralists.Eric Christian Barnes - 2005 - British Journal for the Philosophy of Science 56 (3):421-450.
    Predictivism asserts that novel confirmations carry special probative weight. Epistemic pluralism asserts that the judgments of agents (about, e.g., the probabilities of theories) carry epistemic import. In this paper, I propose a new theory of predictivism that is tailored to pluralistic evaluators of theories. I replace the orthodox notion of use-novelty with a notion of endorsement-novelty, and argue that the intuition that predictivism is true has two roots. I provide a detailed Bayesian rendering of this theory and argue that pluralistic (...)
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  • The Value of Completeness: How Mendeleev Used His Periodic System to Make Predictions.Karoliina Pulkkinen - 2019 - Philosophy of Science 86 (5):1318-1329.
    Dmitrii Mendeleev’s periodic system is known for its predictive accuracy, but talk of its completeness is rarer. This is surprising because completeness was a quality that Mendeleev saw as important for a systematization of the chemical elements. Here, I explain how Mendeleev’s valuing of completeness influenced the development of his periodic system. After introducing five indicators of its completeness, I zoom into one in particular: Mendeleev’s inclusion of a schematic row of oxides. I then show how it guided Mendeleev’s predictions (...)
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  • Accommodation and prediction: The case of the persistent head.David Harker - 2006 - British Journal for the Philosophy of Science 57 (2):309-321.
    A not unpopular thesis, when it comes to the confirmation of scientific theories, is that data which were used in the construction of a theory afford poorer support for that theory than data that played no role. Some compelling thought experiments have been offered in favour of this view, not as proof but rather to add some intuitive plausibility. In this paper I consider such thought experiments and argue that they do not support the thesis; the perceived importance of prediction (...)
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  • Predictive hypotheses are ineffectual in resolving complex biochemical systems.Michael Fry - 2018 - History and Philosophy of the Life Sciences 40 (2):25.
    Scientific hypotheses may either predict particular unknown facts or accommodate previously-known data. Although affirmed predictions are intuitively more rewarding than accommodations of established facts, opinions divide whether predictive hypotheses are also epistemically superior to accommodation hypotheses. This paper examines the contribution of predictive hypotheses to discoveries of several bio-molecular systems. Having all the necessary elements of the system known beforehand, an abstract predictive hypothesis of semiconservative mode of DNA replication was successfully affirmed. However, in defining the genetic code whose biochemical (...)
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  • Chemical Laws, Idealization and Approximation.Emma Tobin - 2013 - Science & Education 22 (7):1581-1592.
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  • How Mendeleev issued his predictions: comment on Andrea Woody.Chris Campbell & Karoliina Pulkkinen - 2020 - Foundations of Chemistry 22 (2):197-215.
    Much has been said about the accuracy of the famous predictions of the Russian chemist Dmitrii Ivanovich Mendeleev, but far less has been written on how he made his predictions. Here we offer an explanation on how Mendeleev used his periodic system to predict both physical and chemical properties of little-known and entirely unknown chemical elements. We argue that there seems to be compelling evidence in favour of Mendeleev genuinely relying on his periodic system in the course of issuing his (...)
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  • The value of laws in chemistry.Vanessa A. Seifert - 2024 - Foundations of Chemistry 26 (3):355-368.
    In philosophy, the empirical success of a science is often explained by the fact that it has managed to discover some law(s) of nature. This line of thought has not been thoroughly explored with respect to chemistry. The aim of this paper is to fill this gap by showing how we could think about laws in chemistry. Specifically, it briefly presents how laws of nature are understood in philosophy of science. It then discusses two case studies from chemistry—the periodic table (...)
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  • Levin and Ghins on the “no miracle” argument and naturalism.Mario Alai - 2012 - European Journal for Philosophy of Science 2 (1):85-110.
    On the basis of Levin’s claim that truth is not a scientific explanatory factor, Michel Ghins argues that the “no miracle” argument (NMA) is not scientific, therefore scientific realism is not a scientific hypothesis, and naturalism is wrong. I argue that there are genuine senses of ‘scientific’ and ‘explanation’ in which truth can yield scientific explanations. Hence, the NMA can be considered scientific in the sense that it hinges on a scientific explanation, it follows a typically scientific inferential pattern (IBE), (...)
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  • Predictivism and avoidance of ad hoc-ness: An empirical study.Samuel Schindler - 2024 - Studies in History and Philosophy of Science Part A 104 (C):68-77.
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  • The problem of chemical laws.Hernan Lucas Accorinti - 2024 - Foundations of Chemistry 26 (3):343-353.
    In this paper, we will address a recurring problem in the field of the general philosophy of science but one that takes on particular relevance in the context of chemistry: the problem surrounding scientific laws. The main challenge is that the laws of chemistry are not universal; moreover, in practice, they are stated alongside numerous exceptions. Given that there are exceptions, we could argue that what the laws assert is neither universally true nor necessary. But if that's the case, are (...)
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  • Periodic law, chemical elements and scientific discoveries: considerations from Norwood Hanson and Thomas Kuhn.Cristina Spolti Lorenzetti, Anabel Cardoso Raicik & Luiz O. Q. Peduzzi - 2024 - Foundations of Chemistry 26 (3):447-465.
    The theme surrounding scientific discoveries is quite neglected in and about the sciences, especially in terms of historical and epistemological understanding. Discoveries are often treated as simple information about dates, places, and people. This work presents discussions centered on historical episodes related to chemical elements and the Periodic Law, based on reflections by Thomas Kuhn and Norwood Hanson, aiming to highlight and contextualize specific scientific discoveries' conceptual and epistemological structure. With that in mind, issues related to the inseparability of the (...)
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  • Il ruolo del sistema periodico degli elementi nel caratterizzare la chimica classica come teoria scientifica.Antonio Drago - 2014 - Epistemologia 37 (1):37-57.
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  • What to make of Mendeleev’s predictions?K. Brad Wray - 2018 - Foundations of Chemistry 21 (2):139-143.
    I critically examine Stewart’s suggestion that we should weigh the various predictions Mendeleev made differently. I argue that in his effort to justify discounting the weight of some of Mendeleev’s failures, Stewart invokes a principle that will, in turn, reduce the weight of some of the successful predictions Mendeleev made. So Stewart’s strategy will not necessarily lead to a net gain in Mendeleev’s favor.
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  • Predictions, retrodictions and the periodic table.Michael Akeroyd - 2003 - Foundations of Chemistry 5 (1):85-88.
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  • The philosophical significance of Mendeleev’s successful predictions of the properties of gallium and scandium.Michael Akeroyd - 2010 - Foundations of Chemistry 12 (2):117-122.
    The philosophical significance of Dmitri Mendeleev’s successful predictions of the properties of gallium and scandium vis a vis the acceptance of the Periodic Table 1874–1886 has been debated recently. This author presents evidence that De Boisbaudran and Cleve both respectively predicted the possible existence of gallium and scandium, but on the basis of the old TRIAD methodology. This suggests that these successful Mendeleev predictions were therefore not independent corroboration of the concept of the Periodic System. Instead the significantly independent predictive (...)
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  • Prediction and Novel Facts in the Methodology of Scientific Research Programs.Wenceslao J. Gonzalez - 2015 - In Philosophico-Methodological Analysis of Prediction and its Role in Economics. Cham: Imprint: Springer. pp. 103-124.
    In the methodology of scientific research programs (MSRP) there are important features on the problem of prediction, especially regarding novel facts. In his approach, Imre Lakatos proposed three different levels on prediction: aim, process, and assessment. Chapter 5 pays attention to the characterization of prediction in the methodology of research programs. Thus, it takes into account several features: (1) its pragmatic characterization, (2) the logical perspective as a proposition, (3) the epistemological component, (4) its role in the appraisal of research (...)
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  • How to be a scientific realist (if at all): a study of partial realism.Dean Peters - 2012 - Dissertation, London School of Economics
    "Partial realism" is a common position in the contemporary philosophy of science literature. It states that the "essential" elements of empirically successful scientific theories accurately represent corresponding features the world. This thesis makes several novel contributions related to this position. Firstly, it offers a new definition of the concept of “empirical success”, representing a principled merger between the use-novelty and unification accounts. Secondly, it provides a comparative critical analysis of various accounts of which elements are "essential" to the success of (...)
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  • Prediction, accommodation and the periodic table: a reappraisal.Sergio Gabriele Maria Sereno - 2020 - Foundations of Chemistry 22 (3):477-488.
    The history of the diffusion and confirmation of Mendeleev’s periodic table of elements has proven to be a challenging testbed for contemporary philosophical debates on the role of predictions in science. More than ten years of fruitful literature came after Scerri and Worrall :407–452, 2001) versus Maher and Lipton ; nevertheless, such a long-lasting debate left quite a few open questions. The aim of this contribution is to go through the various cases that emerged during the debate, in an effort (...)
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  • Two arguments for scientific realism unified.Harker David - 2010 - Studies in History and Philosophy of Science Part A 41 (2):192-202.
    Inferences from scientific success to the approximate truth of successful theories remain central to the most influential arguments for scientific realism. Challenges to such inferences, however, based on radical discontinuities within the history of science, have motivated a distinctive style of revision to the original argument. Conceding the historical claim, selective realists argue that accompanying even the most revolutionary change is the retention of significant parts of replaced theories, and that a realist attitude towards the systematically retained constituents of our (...)
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  • Breaking the law: Promoting domain-specificity in chemical education in the context of arguing about the periodic law. [REVIEW]Sibel Erduran - 2007 - Foundations of Chemistry 9 (3):247-263.
    In this paper, domain-specificity is presented as an understudied problem in chemical education. This argument is unpacked by drawing from two bodies of literature: learning of science and epistemology of science, both themes that have cognitive as well as philosophical undertones. The wider context is students’ engagement in scientific inquiry, an important goal for science education and one that has not been well executed in everyday classrooms. The focus on science learning illustrates the role of domain specificity in scientific reasoning. (...)
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  • Mendeleev's discovery of the periodic law: The origin and the reception. [REVIEW]Masanori Kaji - 2003 - Foundations of Chemistry 5 (3):189-214.
    This paper addresses the conceptual as well as social origins of Mendeleev’s discovery of the periodic law and its reception by the chemical community by taking account of three factors: Mendeleev’s early research and its relevance to the discovery; his concepts of chemistry, especially that of the chemical elements; and the social context of the discovery and the reception in the chemical community. Mendeleev's clear distinction between abstract elements and simple bodies was a departure from Lavoisier’s famous definition of elements (...)
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  • Crick's Adaptor Hypothesis and the Discovery of Transfer RNA: Experiment Surpassing Theoretical Prediction.Michael Fry - 2022 - Philosophy, Theory, and Practice in Biology 14 (11):1-31.
    Historically, hypotheses failed in most cases to correctly forecast the workings of complex biological systems. Francis Crick’s adaptor hypothesis, however, stands out as an exceptional case of a confirmed abstract prediction. This hypothesis presciently anticipated the existence of RNA adaptors that function as bridges between amino acids and the chemically different nucleic acid template for proteins. Crick conjectured that the adaptors are enzymatically charged with cognate amino acids, they bind to complementary protein-coding nucleic acid, and their liberated amino acids are (...)
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