Antibiotic-resistant bacteria pose a serious threat to our health. Our ability to destroy deadly bacteria by using antibiotics have not only improved our lives by curing infections, it also allows us to undertake otherwise dangerous treatments from chemotherapies to invasive surgeries. The emergence of antibiotic resistance, I argue, is a consequence of various iterations of prisoner’s dilemmas. To wit, each participant (from patients to nations) has rational self-interest to pursue a course of action that is suboptimal for (...) all of us. The standard solutions to prisoner’s dilemma look to realign cost-benefit such that individuals’ interests match those of the collective. However, the lack of a global organization to enforce an effective carrot-and-stick system makes it unlikely that we can solve the antibiotic resistance problem this way. I argue that our best chance might be an attempt to teach altruism and convince individuals to act not out of their self-interests. (shrink)

Self-medication of antibiotics is an irrational use of drugs, contributing to microbial resistance, increasing healthcare costs and higher mortality and morbidity. This study aimed to assess self-medication with antibiotics without a medical prescription in the community of Libya. This is a cross-sectional study conducted from June to December 2022 and the total number of participants was 200. The design of the study and sample size were modified according to the proficiency of pharmacists and the medical and non-medical population of (...) Libya. The questionnaire was developed in English and Arabic language and was distributed through social media platforms. The questions were used after a thorough literature search and assessing the validity and reliability. The significant signs regarding reasons for the treatment by self-medication drugs of antibiotics, because of its various drugs of antibiotic by pharmacist (n=80, 40.0%) and family (n=90, 45.0%) compared with experience and physicians by used prescription was 13 (6.50%) and significant sings regarding by nasal congestion self-medication of various antibiotics (n=100, 50.0%). This sign must be practiced based on a previous physician’s prescription. The antibiotics are often self-administered as patients feel that they will save money and time but this can lead to substantial adverse drug reactions, antibiotic resistance, treatment failure and drug-related toxicity. This study respondent's medical and non-medical public of Libya who should be relatively informed and educated about the risk of treatment by self-medication of antibiotics with the development of resistance. (shrink)

Background: Increasing resistance of Pseudomonas aeruginosa to ciprofloxacin in ICU/burn units has created a problem in the treatment of infections caused by this microorganism. -/- Methods: Fifty P. aeruginosa strains were isolated from burn patients hospitalized in the Kerman Hospital during May 1999-April 2000 and were tested for in-vitro sensitivity to different antibiotics by disc diffusion breakpoint assay. The isolates were subjected to minimum inhibitory concentration (MIC) test by agar dilution method. Existence of the plasmids was also investigated in (...) the isolates. -/- Results: Thirty-four patients infected with ciprofloxacin strains showed MIC of 8 mg/ml [p<0.001]. Sixteen patients were infected with sensitive strains exhibiting MIC range of 0.0125-0.125 ± 0.033 mg/ml. The isolates were also also resistant to other antibiotics [p<0.001]. Plasmid isolation and agarose gel electrophoresis (0.7%) revealed three plasmid bands in strains 8 and 16, and one band in strain 35. -/- Conclusion: The emergence of ciprofloxacin resistance of P. aeruginosa in burn patients is alarming since this antibiotic has only recently been introduced onto the market in Iran. One important observation was that some isolates exhibited cross resistance to other antibiotics. Furthermore, some strains were carriers of plasmids which might have acted as the potential source of acquired resistance in the hospital setting. -/- . (shrink)

See "What's Wrong with Factory Farming?" (2015) for an updated treatment of these issues.

Antimicrobial resistance (AMR) is a global public health disaster driven largely by antibiotic use in human health care. Doctors considering whether to prescribe antibiotics face an ethical conflict between upholding individual patient health and advancing public health aims. Existing literature mainly examines whether patients awaiting consultations desire or expect to receive antibiotic prescriptions, but does not report views of the wider public regarding conditions under which doctors should prescribe antibiotics. It also does not explore the ethical significance (...) of public views or their sensitivity to awareness of AMR risks or the standpoint (self-interested or impartial) taken by participants. Methods: An online survey was conducted with a sample of the U.S. public (n = 158). Participants were asked to indicate what relative priority should be given to individual patients and society-at-large from various standpoints and in various contexts, including antibiotic prescription. Results: Of the participants, 50.3% thought that doctors should generally prioritize individual patients over society, whereas 32.0% prioritized society over individual patients. When asked in the context of AMR, 39.2% prioritized individuals whereas 45.5% prioritized society. Participants were significantly less willing to prioritize society over individuals when they themselves were the patient, both in general (p = .001) and in relation to AMR specifically (p = .006). Conclusions: Participants’ attitudes were more oriented to society and sensitive to collective responsibility when informed about the social costs of antibiotic use and when considered from a third-person rather than first-person perspective. That is, as participants came closer to taking the perspective of an informed and impartial “ideal observer,” their support for prioritizing society increased. Our findings suggest that, insofar as antibiotic policies and practices should be informed by attitudes that are impartial and well-informed, there is significant support for prioritizing society. (shrink)

Introduction: In our study, we aimed to examine the strains isolated from vaginal swab samples sent to our laboratory from various clinics with a pre-diagnosis of vulvovaginitis and antibiotic resistance rates, retrospectively.

This paper addresses a family of issues surrounding the biological phenomenon of resistance and its representation in realist ontologies. The treatments of resistance terms in various existing ontologies are examined and found to be either overly narrow, internally inconsistent, or otherwise problematic. We propose a more coherent characterization of resistance in terms of what we shall call blocking dispositions, which are collections of mutually coordinated dispositions which are of such a sort that they cannot undergo simultaneous realization (...) within a single bearer. A definition of ‘protective resistance’ is proposed for use in the Infectious Disease Ontology (IDO) and we show how this definition can be used to characterize the antibiotic resistance in Methicillin-Resistant Staphylococcus aureus (MRSA). The ontological relations between entities in our MRSA case study are used alongside a series of logical inference rules to illustrate logical reasoning about resistance. A description logic representation of blocking dispositions is also provided. We demonstrate that our characterization of resistance is sufficiently general to cover two other cases of resistance in the infectious disease domain involving HIV and malaria. (shrink)

Microbial biofilm created huge burden in treatment of both community and hospital infections. A biofilm is complex communities of bacteria attached to a surface or interface enclosed in an exopolysaccharide matrix and protected from unfavorable conditions such as presence of antibiotics, host defense or oxidative stresses. Biofilms are often considered hot spot for horizontal gene transfer among same or different bacterial species. Furthermore, bacteria with increased hydrophobicity facilitate biofilm formation by reducing repulsion between the extracellular matrix and the bacterium. There (...) is a marked increase in the rate of persons nonresponsive to antibiotic therapy for infections of the Urinary Tract (UTIs), burns and upper respiratory tract due to biofilm formations. It is estimated that 90% of nosocomial infections are mediated by biofilm. The role of biofilm in infections has become so great that the treatment of such antibiotic resistance infections is proving difficult and costly to health care systems. The biofilm related infections varied from dental plaque, destruction of prosthetic valve to death of cystic fibrosis patients. This review aims to provide a summary of role of bacterial biofilm and its clinical implications for the patients. (shrink)

Objective: The objective of this study was to evaluate the clinical efficacy and appropriateness of colistin therapy in patients with hematological malignancies. -/- Methods: Age, gender, type of hematologic malignancy, and potential carbapenem-resistant microorganism risk factors were all noted in this retrospective study. In empirical and agent-specific treatment groups, differences in demographic features, risk factors, treatment responses, and side effects were compared. -/- Results: Sixty-three patients were included, 54% were male, and the median age was 49. In the last three (...) months, the hospitalization rate history was 68%, and four patients had a hospitalization history in the ICU. Carbapenem-resistant K. pneumoniae colonization was present in 22 patients (35%). Gram-negative microorganisms were isolated in 34 patients (54%). The carbapenem, quinolone, and colistin resistance rates were 82%, 76%, and 4% respectively. Clinical and microbiological response rates were 60% and 69%. 7 and 28-day mortality rates were 17% and 35%. There was no significant difference in demographic data and comorbidities in empirical (n=48) and agent-specific (n=15) treatment groups. The rate of carbapenem and glycopeptide treatments before colistin was higher in the empirical treatment group (p = 0.004; p = 0.001). The rate of starting combined antibiotics was higher in the empirical treatment group (p = 0.016). Two of the patients developed renal failure in the first week after treatment. -/- Conclusion: The use of empirical colistin may be unavoidable given the risk considerations. Shortly, colistin-resistant strains may also be a factor affecting treatment success negatively. (shrink)

Forty years’ experience as a bacterial geneticist has taught me that bacteria possess many cognitive, computational and evolutionary capabilities unimaginable in the first six decades of the twentieth century. Analysis of cellular processes such as metabolism, regulation of protein synthesis, and DNA repair established that bacteria continually monitor their external and internal environments and compute functional outputs based on information provided by their sensory apparatus. Studies of genetic recombination, lysogeny, antibiotic resistance and my own work on transposable elements (...) revealed multiple widespread bacterial systems for mobilizing and engineering DNA molecules. Examination of colony development and organization led me to appreciate how extensive multicellular collaboration is among the majority of bacterial species. Contemporary research in many laboratories on cell–cell signaling, symbiosis and pathogenesis show that bacteria utilise sophisticated mechanisms for intercellular communication and even have the ability to commandeer the basic cell biology of ‘higher’ plants and animals to meet their own needs. This remarkable series of observations requires us to revise basic ideas about biological information processing and recognise that even the smallest cells are sentient beings. (shrink)

Surveillance programs supporting the management of One Health issues such as antibiotic resistance are complex systems in themselves. Designing ethical surveillance systems is thus a complex task (retroactive and iterative), yet one that is also complicated to implement and evaluate (e.g., sharing, collaboration, and governance). The governance of health surveillance requires attention to ethical concerns about data and knowledge (e.g., performance, trust, accountability, and transparency) and empowerment ethics, also referred to as a form of responsible self-governance. Ethics in (...) reflexive governance operates as a systematic critical-thinking procedure that aims to define its value: What are the “right” criteria to justify how to govern “good” actions for a “better” future? The objective is to lay the foundations for a methodological framework in empirical bioethics, the rudiments of which have been applied to a case study to building reflexive governance in One Health. This ongoing critical thinking process involves “mapping, framing, and shaping” the dynamics of interests and perspectives that could jeopardize a “better” future. This paper proposes to hybridize methods to combine insights from collective deliberation and expert evaluation through a reflexive governance functioning as a community-based action-ethics methodology. The intention is to empower individuals and associations in a dialogue with society, which operation is carried out using a case study approach on data sharing systems. We based our reasoning on a feasibility study conducted in Québec, Canada (2018–2021), envisioning an antibiotic use surveillance program in animal health for 2023. Using the adaptive cycle and governance techniques and perspectives, we synthesize an alternative governance model rooted in the value of empowerment. The framework, depicted as a new “research and design (R&D)” practice, is linking operation and innovation by bridging the gap between Reflexive, Evaluative, and Deliberative reasonings and by intellectualizing the management of democratizing critical thinking locally (collective ethics) by recognizing its context (social ethics). Drawing on the literature in One Health and sustainable development studies, this article describes how a communitarian and pragmatic approach can broaden the vision of feasibility studies to ease collaboration through public-private-academic partnerships. The result is a process that “reassembles” the One Health paradigm under the perspective of global bioethics to create bridges between the person and the ecosystem through pragmatic ethics. (shrink)

The world is in a state of crisis. Global problems that threaten our future include: the climate crisis; the destruction of natural habitats, catastrophic loss of wild life, and mass extinction of species; lethal modern war; the spread of modern armaments; the menace of nuclear weapons; pollution of earth, sea and air; rapid rise in the human population; increasing antibiotic resistance; the degradation of democratic politics, brought about in part by the internet. It is not just that universities (...) around the world have failed to help humanity solve these global problems; even worse, they have made the genesis of these problems possible. Modern science and technology, developed in universities, have made possible modern industry and agriculture, modern hygiene and medicine, modern power production and travel, modern armaments, which in turn make possible much that is good, all the great benefits of the modern world, but also all the global crises that now threaten our future. What has gone wrong? The fault lies with the whole conception of inquiry built into universities around the world. The basic idea is to help promote human welfare by, in the first instance, acquiring scientific knowledge and technological know-how. First, knowledge is to be acquired; once acquired, it can be applied to help solve social problems, and promote human welfare. But this basic idea is an intellectual disaster. Judged from the standpoint of promoting human welfare, it is profoundly and damagingly irrational, in a structural way. As a result of being restricted to the tasks of acquiring and applying knowledge, universities are prevented from doing what they most need to do to help humanity solve global problems, namely, engage actively with the public to promote action designed to solve global problems. We need urgently to bring about a revolution in universities around the world, wherever possible, so that their central task becomes to help humanity learn how to solve the climate crisis and other problems of living, local and global, so that we may make progress towards a good, civilized world. Almost every branch and aspect of the university needs to change. (shrink)

The Consequences of Human Overpopulation: Nature’s Automatic Balancing Mechanism -/- Introduction -/- Throughout history, civilizations have risen and fallen due to their ability—or failure—to manage resources and population growth. In today’s world, human overpopulation has reached an unprecedented scale, straining ecosystems, depleting resources, and accelerating climate change. If population growth remains unchecked, nature will impose its own form of balance through disease, war, famine, and environmental collapse. This essay explores how overpopulation mirrors invasive species behavior and how nature’s corrective mechanisms (...) will inevitably restore equilibrium if humans fail to act. -/- Human Overpopulation as an Invasive Species Phenomenon -/- In ecology, an invasive species is one that spreads uncontrollably, outcompeting native species and destabilizing ecosystems. Humans fit this description in many ways. Over the past centuries, human populations have expanded across the planet, altering environments, driving species to extinction, and consuming resources at an unsustainable rate. -/- Characteristics of an Invasive Species in Human Behavior: -/- 1. Uncontrolled Growth – The human population has increased exponentially, surpassing eight billion and continuing to rise. -/- 2. Resource Overconsumption – Forests are cleared, water sources are depleted, and fossil fuels are burned at unsustainable rates. -/- 3. Disruption of Ecosystems – Pollution, habitat destruction, and climate change have permanently altered natural cycles. -/- 4. Lack of Natural Population Control – Unlike other species, humans have eliminated most natural predators and diseases through medicine and technology. -/- When any species exceeds the carrying capacity of its environment, nature enforces balance through survival pressures. Humanity is not exempt from this rule. -/- Nature’s Methods of Population Control -/- If humans fail to regulate their own numbers, natural forces will intervene. The following mechanisms have historically served as population checks and will continue to do so: -/- 1. Disease and Pandemics -/- Throughout history, pandemics have significantly reduced human populations. The Black Death in the 14th century wiped out nearly 50% of Europe’s population, and more recently, COVID-19 caused millions of deaths worldwide. Overpopulation leads to dense urban areas where diseases spread rapidly. Additionally, antibiotic resistance and new viruses could emerge as unintended consequences of human activity, leading to more devastating outbreaks. -/- 2. War and Conflict -/- As resources become scarce, competition intensifies. Wars often arise from disputes over land, water, food, and energy. In modern times, conflicts in regions suffering from overpopulation and resource depletion—such as the Middle East and parts of Africa—demonstrate this pattern. Future conflicts over freshwater, fertile land, and energy resources are highly likely. -/- 3. Famine and Food Shortages -/- The global food supply is under strain as agricultural land becomes exhausted and climate change disrupts weather patterns. As the population grows, the demand for food increases, but overfarming leads to soil degradation, making it harder to produce enough food. Countries already facing food insecurity will suffer the most, leading to malnutrition, starvation, and potential mass migrations. -/- 4. Environmental Collapse -/- Unchecked human activity is leading to deforestation, biodiversity loss, and pollution. Climate change, fueled by overpopulation and industrialization, is causing more frequent and severe natural disasters, including hurricanes, droughts, and wildfires. These environmental catastrophes will destroy infrastructure, displace millions, and further strain already limited resources. -/- 5. Social Breakdown and Crime -/- Overpopulation leads to overcrowded cities, economic inequality, and competition for jobs and resources. In societies where basic needs cannot be met, crime rates rise, and social unrest becomes more frequent. Countries with high population densities and weak governance structures are already experiencing increased violence, civil conflicts, and failing economies. -/- Can Humanity Avoid Nature’s Harsh Correction? -/- Unlike other species, humans have the ability to recognize and mitigate the consequences of their actions. There are two possible paths: -/- 1. Self-Regulation Through Sustainable Policies -/- Governments and organizations can promote family planning, education, and birth control to stabilize population growth. -/- Shifting toward sustainable agriculture, renewable energy, and resource conservation can help prevent environmental collapse. -/- Strengthening international cooperation to manage resource distribution and prevent conflicts can reduce the risks of war and famine. -/- 2. Ignoring the Problem and Facing Natural Consequences -/- If humanity refuses to control its population, disease, war, famine, and environmental collapse will enforce balance. -/- The poorest regions will suffer first, but wealthier nations will also experience economic decline, migration crises, and societal breakdown. -/- Conclusion -/- Human overpopulation follows the pattern of an invasive species, consuming resources at an unsustainable rate and destabilizing ecosystems. While humans have the intelligence and technology to regulate their own numbers, history suggests that if we fail to act, nature will impose balance through suffering and destruction. Whether through pandemics, war, famine, or climate disasters, population control will occur—either by human intervention or by nature’s unforgiving hand. -/- The choice is clear: Will humanity take responsibility for its future, or will we wait for nature to correct our mistakes in the most brutal way possible? -/- . (shrink)

Two great problems of learning confront humanity: learning about the universe, and about ourselves and other living things as a part of the universe; and learning how to create a good, civilized, enlightened, wise world. We have solved the first great problem of learning – we did that when we created modern science and technology in the 17th century. But we have not yet solved the second one. That combination of solving the first problem, failing to solve the second one, (...) is very, very, dangerous. Almost all our current global problems have arisen as a result. Modern science and technology immensely increase our powers to act (for some of us), but not our power to act wisely. Modern science and technology lead to modern industry, modern agriculture, travel, medicine, hygiene and armaments, and these in turn lead to much that is of benefit, but also to all our current global problems: population growth, habitat destruction, loss of wild life, mass extinction of species, lethal modern war, the menace of nuclear weapons, pollution of earth, sea and air, antibiotic resistance, degradation of democracy facilitated by the internet and, most serious of all, the climate crisis. Now that we have modern science and technology, wisdom has become, not a private luxury, but a public necessity. But how is it to be achieved? Here is the solution. We can learn from the solution to the first great problem of learning how to solve the second one. That was the basic idea of the 18th century Enlightenment, but in implementing it, the philosophes of the Enlightenment blundered. They got the progress-achieving methods of science wrong; they failed to generalize them properly; and they applied them, not to social life but to creating social science. Their mistakes are still built into academia today. In order to learn how to create a civilized, enlightened world, the key thing we need to do is to cure academia of the structural blunders we have inherited from the Enlightenment. We need to bring about a revolution in science, and in academia more broadly so that the basic aim becomes wisdom, and not just knowledge – wisdom being the capacity, active endeavour and desire to realize what is of value in life for oneself and others, wisdom thus including knowledge and technological know-how, but much else besides. The outcome of the revolution we need would be universities radically transformed, so that they become rationally and actively devoted to helping people solve problems of living, including global problems, thus making progress to as good, civilized, enlightened a world as possible. (shrink)

Clinical microbiology serves as a partner to clinicians in the diagnosis and treatment of infectious diseases. Antibiotics are prescribed empirically before the availability of antimicrobial susceptibility testing data, especially when the patient's medical status could deteriorate by suspending the treatment. To investigate the impact of antimicrobial susceptibility testing on the management of outpatients with suspected bacterial infection in Libyan patients, a cross-sectional prospective study concluded on microbial microdroplet culture by including outpatients with suspected bacterial infection, who have done antimicrobial susceptibility (...) testing. Thus, 53 Libyan patients with urinary tract infections and 14 Libyan patients with skin infections were included in this study. Before the availability of antimicrobial susceptibility testing data, 25 patients were appropriately treated while 42 patients were inappropriately treated. After the availability of antimicrobial susceptibility testing data, the number of appropriately treated patients increased to 57 patients. Thus, antimicrobial susceptibility testing improved the management of 41 patients by discontinuing an unnecessary antibiotic in four patients, starting necessary antibiotic therapy in 18 patients, and changing to more appropriate antibiotic in 19 patients. However, the antimicrobial susceptibility testing has no impact on the management of 24 patients and has led to the worsening of the management of two patients. The effect of antimicrobial susceptibility testing of antibiotic de-escalation was assessed in 35 patients; however, antibiotic de-escalation occurred in six patients. Thus, data of antimicrobial susceptibility testing has improved the management of Libyan outpatients with bacterial infection but their role in antibiotic de-escalation was slight. (shrink)

This chapter explores the question of whether or not individual agents are under a moral obligation to reduce their ‘antimicrobial footprint’. An agent’s antimicrobial footprint measures the extent to which her actions are causally linked to the use of antibiotics. As such, it is not necessarily a measure of her contribution to antimicrobial resistance. Talking about people’s antimicrobial footprint in a way we talk about our carbon footprint may be helpful for drawing attention to the global effects of individual (...) behaviour and for highlighting that our choices can collectively make a real difference. But can we be morally obligated to make a contribution to resolving a collective action problem when our individual contributions by themselves make no discernible difference? I will focus on two lines of argument in favour of such obligations: whether a failure to reduce one’s antimicrobial footprint is unfair and whether it constitutes wrongdoing because it is harmful. I conclude by suggesting that the argument from collective harm is ultimately more successful. (shrink)

In this paper, we redefine the target of evolutionary explanations by proposing the “evosystem” as an alternative to populations, lineages and species. Evosystems account for changes in the distribution of heritable variation within individual Darwinian populations (evolution by natural selection, drift, or constructive neutral evolution), but also for changes in the networks of interactions within or between Darwinian populations and changes in the abiotic environment (whether these changes are caused by the organic entities or not). The evosystem can thereby become (...) a centerpiece for a redefined evolutionary science, that is, evolutionary studies, that apprehends through a single framework the variety of evolutionary processes that lie at various scales. To illustrate the importance of this broadened perspective on evolution, we use a case of antimicrobial resistance evolution: the spread of the blaNDM gene family and the related resistance to carbapenem antibiotics observed globally, and show how evolutionary studies can contribute to answering contemporary socially relevant challenges. (shrink)

Creativity and Intelligence: Emergent Properties of the Brain as a Balancing Mechanism for Overpopulation, Natural Disasters, and Diseases -/- The human brain is an extraordinary organ, capable of producing creativity and intelligence as emergent properties that allow humanity to address complex challenges. These traits are not merely tools for individual survival; they function as collective mechanisms to adapt to large-scale issues that threaten humanity’s balance with the environment. Overpopulation, natural disasters, and the prevalence of diseases and illnesses represent some of (...) the most significant pressures on human societies. Through the brain’s capacity for problem-solving and innovation, humanity has developed strategies to mitigate these challenges and maintain equilibrium within the universal law of balance. -/- The Brain as a Balancing Mechanism -/- At its essence, the brain operates as a dynamic system that processes external stimuli and generates adaptive responses. Creativity and intelligence arise from this system as tools to predict, analyze, and address challenges that disrupt balance. Overpopulation, natural disasters, and diseases disrupt human life on social, economic, and environmental levels, testing the brain’s ability to create solutions. -/- Creativity in Addressing Overpopulation -/- Overpopulation places immense strain on resources, ecosystems, and social structures, often leading to food shortages, environmental degradation, and urban overcrowding. The brain’s creative capacity has allowed humans to develop innovations to address these issues. Urban agriculture, such as vertical farming, is an example of how creativity has transformed food production in densely populated areas, reducing dependence on traditional farmland and conserving resources. Similarly, advancements in renewable energy technologies, such as solar and wind power, reduce the ecological footprint of growing populations, providing sustainable solutions to energy needs. -/- Creativity also plays a critical role in social policies and education. Family planning programs and reproductive health education have empowered individuals, particularly women, to make informed decisions, reducing population growth rates in many regions. These initiatives reflect the brain’s ability to create holistic solutions that align societal needs with the preservation of natural balance. -/- Intelligence in Managing Natural Disasters -/- Natural disasters, unpredictable and often catastrophic, require intelligent strategies to mitigate their impact. Intelligence enables humans to analyze data, predict disasters, and prepare for their consequences. Early warning systems for tsunamis, hurricanes, and earthquakes exemplify this, providing communities with critical time to evacuate and take protective measures. -/- Furthermore, intelligence drives the design of resilient infrastructure that can withstand disasters. For instance, earthquake-resistant buildings and flood mitigation systems demonstrate the brain’s capacity to transform scientific knowledge into practical solutions. These innovations save lives, reduce economic losses, and facilitate faster recovery after disasters, ensuring that human societies maintain their balance despite nature’s unpredictability. -/- Creativity and Intelligence in Combating Diseases and Illnesses -/- Diseases and illnesses have long been among humanity’s greatest challenges, especially in the context of overpopulation, which facilitates the rapid spread of infectious diseases. The brain’s emergent properties of creativity and intelligence have been critical in combating these threats through advancements in medicine, public health, and technology. -/- The development of vaccines, antibiotics, and antiviral drugs highlights humanity’s creative response to disease. For example, the eradication of smallpox and the near-elimination of polio are milestones achieved through creative and intelligent applications of medical science. During the COVID-19 pandemic, intelligence and creativity led to the rapid development of vaccines using mRNA technology, showcasing the brain’s ability to adapt to new challenges at an unprecedented pace. -/- Public health strategies, such as sanitation systems, clean water initiatives, and disease surveillance networks, also reflect the brain’s ability to create systemic solutions. These measures have significantly reduced the burden of communicable diseases, particularly in densely populated areas. Moreover, advancements in artificial intelligence and biotechnology continue to enhance humanity’s ability to detect, prevent, and treat illnesses. -/- The Interplay of Creativity, Intelligence, and Feedback Mechanisms -/- Creativity and intelligence act as feedback mechanisms that enable humans to respond to disruptions while maintaining balance within the universal law of nature. Overpopulation, natural disasters, and diseases disrupt this balance, prompting the brain to generate solutions that restore harmony. -/- For instance, urban planning that incorporates green spaces and sustainable infrastructure addresses the environmental strain caused by overpopulation. Similarly, the integration of traditional knowledge with modern technologies enhances disaster resilience. In the context of diseases, the collaboration of global institutions and local communities reflects the brain’s capacity to balance innovation with cultural and social considerations. -/- Challenges and Ethical Considerations -/- While creativity and intelligence empower humanity to address these challenges, they also carry significant ethical responsibilities. Technological advancements must align with principles of sustainability and equity. For example, while vaccines have saved millions of lives, unequal access to these innovations highlights the need for ethical distribution systems. Similarly, urban development projects must prioritize environmental conservation and community well-being to avoid exacerbating existing imbalances. -/- Additionally, the misuse of intelligence and creativity—such as the development of biological weapons or unsustainable industrial practices—can worsen the effects of overpopulation, natural disasters, and diseases. Ensuring that human ingenuity aligns with the principles of balance and harmony is essential to avoid unintended consequences. -/- Conclusion -/- Creativity and intelligence are emergent properties of the human brain that have enabled humanity to adapt to and mitigate the negative effects of overpopulation, natural disasters, and diseases. These traits function as balancing mechanisms, allowing humans to innovate and maintain harmony within the framework of natural laws. However, the application of these capabilities must be guided by ethical considerations and a commitment to sustainability. By aligning human creativity and intelligence with the universal law of balance, humanity can navigate its most pressing challenges and build a more resilient and equitable future. -/- . (shrink)

The Unified Theory of Free Will: The Three Universal Laws, Systemic Imbalance, and Nature’s Self-Correction -/- By Angelito Malicse -/- Introduction -/- For centuries, the concept of free will has been debated, with perspectives ranging from determinism to compatibilism and libertarianism. However, these traditional views fail to acknowledge the natural laws that govern human decision-making. By synthesizing the Universal Law of Balance in Nature, the Universal Feedback Loop Mechanism, and the Error-Free System, we establish a unified theory of free will—a (...) structured approach to human choices within the constraints of natural order. -/- Additionally, it is crucial to recognize the tolerance limits of hierarchical systems—both natural and man-made. When human decisions exceed these limits and imbalances persist, nature will automatically step in to restore equilibrium. This natural correction often manifests in disruptive ways, such as natural disasters, economic collapses, or social upheavals. Understanding these dynamics is essential to ensuring stability across all systems. -/- Furthermore, human emotions, which have evolved as essential survival mechanisms, play a dual role in maintaining or disrupting balance. Emotions influence decision-making, motivation, and social interactions. When properly regulated, they help individuals and societies adapt to challenges and maintain systemic harmony. However, when emotions exceed their tolerance limits—such as excessive fear leading to panic or unchecked anger causing conflict—they contribute to systemic imbalance and dysfunction. -/- The Three Universal Laws and Their Role in Decision-Making -/- 1. Universal Law of Balance in Nature -/- Every system—biological, social, and technological—operates within specific tolerance limits. Decisions that align with natural balance maintain stability, while those that exceed these limits lead to disruption. If humans fail to correct imbalances, nature will forcefully restore equilibrium, often through unpredictable and catastrophic means. -/- Examples of Balance, Systemic Imbalance, and Natural Correction: -/- Personal Health: A balanced diet sustains physical well-being, while excessive consumption leads to obesity and related diseases. If ignored, the body self-corrects through metabolic disorders and immune system responses. -/- Economic Stability: A balanced economy fosters growth, while financial mismanagement leads to economic crashes. Recessions and inflation serve as corrective mechanisms for financial excesses. -/- Environmental Sustainability: Responsible resource management ensures long-term survival, whereas overexploitation leads to climate change and natural disasters such as droughts and hurricanes, which force societies to adapt. -/- Ecosystem Regulation: Overfishing disrupts marine populations, but nature counters with species migration and ecological shifts that eventually restore stability. -/- Energy Consumption: Overuse of fossil fuels accelerates climate change, prompting extreme weather events and necessitating the shift to renewable energy sources. -/- 2. Universal Feedback Loop Mechanism -/- Decision-making must incorporate continuous feedback to ensure adaptation and refinement. Ignoring or distorting feedback results in inefficiencies and systemic collapse. -/- Examples of Feedback, Systemic Imbalance, and Nature’s Response: -/- Business Adaptation: Companies that respond to consumer feedback thrive, while those that ignore it collapse due to declining market relevance. -/- Political Governance: Leaders who suppress public concerns foster unrest, often leading to revolutions or government overhauls. -/- Technological Development: AI systems trained on biased or incomplete data develop flawed decision-making patterns, necessitating retraining and regulation. -/- 3. Error-Free System -/- Every decision has consequences, and ensuring 100 percent correct information is essential to maintaining systemic balance. Errors in data, assumptions, or implementation can trigger unintended disruptions. -/- Examples of Cause and Effect, Misinformation, and Systemic Collapse: -/- Academic Success: Proper study methods enhance learning, while reliance on ineffective strategies results in poor educational outcomes. -/- Industrialization and Environmental Impact: Sustainable practices protect ecosystems, while reliance on false environmental data accelerates degradation. -/- Global Resource Consumption: Inaccurate assessments of resource availability lead to economic and geopolitical instability. -/- The Evolution and Purpose of the Duality of Human Emotions -/- Human emotions have evolved as critical mechanisms for survival, adaptation, and social cohesion. They function as regulatory signals that guide decision-making, helping individuals and societies maintain equilibrium. However, emotions also possess a dual nature, where their misalignment or overexpression can lead to instability and dysfunction. -/- Positive Role of Emotions in Systemic Balance: -/- Empathy and Cooperation: Emotions such as compassion and trust foster social cohesion, strengthening communities and enhancing cooperation. -/- Fear and Caution: A moderate level of fear helps individuals assess risks and avoid dangerous situations, ensuring personal and collective safety. -/- Motivation and Ambition: Positive emotions such as enthusiasm and joy drive personal growth, innovation, and societal progress. -/- Negative Role of Emotions in Systemic Imbalance: -/- Excessive Fear and Panic: When fear surpasses a system’s tolerance limit, it leads to irrational decision-making, paranoia, and social instability. -/- Unchecked Anger and Conflict: Intense anger without regulation contributes to violence, political unrest, and societal fragmentation. -/- Despair and Apathy: Chronic negative emotions, such as depression and hopelessness, reduce individual productivity and can weaken societal resilience. -/- Examples of Emotional Duality in Decision-Making: -/- Public Health Responses: Balanced fear leads to precautionary health measures, while excessive panic results in chaos (e.g., misinformation-fueled reactions during pandemics). -/- Leadership and Governance: A compassionate leader fosters unity, while an authoritarian leader driven by anger and paranoia destabilizes societies. -/- Market Behavior: Optimistic investors drive economic growth, while fear-driven panic selling causes financial crashes. -/- Effects of Systemic Imbalances and Nature’s Automatic Correction -/- When human decisions disrupt equilibrium and corrective actions are not taken, nature enforces balance through forceful interventions. -/- Examples of Human-Induced Imbalances and Nature’s Response: -/- Healthcare Systems: Overuse of antibiotics results in drug-resistant bacteria, increasing disease severity and forcing new medical advancements. -/- Economic Systems: Financial bubbles burst, leading to recessions that correct speculative excesses. -/- Political Systems: Corrupt governance leads to revolutions, shifts in power, and societal restructuring. -/- Environmental Systems: Deforestation causes soil erosion and desertification, forcing human migrations and altering agriculture. -/- Overpopulation: Excessive growth strains resources, leading to food shortages, pandemics, and natural events that regulate population levels. -/- Urban Expansion: Overcrowding leads to declining infrastructure, pollution, and social conflicts, often prompting mass relocations and policy reforms. -/- Conclusion -/- Free will is not an arbitrary concept but a structured system governed by natural laws. By understanding the Universal Law of Balance in Nature, the Universal Feedback Loop Mechanism, and the Error-Free System, we can align human decisions with nature’s equilibrium. -/- Additionally, recognizing the evolution and duality of human emotions is essential for maintaining stability in personal and societal decision-making. If humanity fails to correct imbalances, nature will automatically restore equilibrium, often in ways that are catastrophic and beyond human control. -/- By integrating these principles into education, governance, and AI development, we pave the way for a rational, ethical, and self-correcting society. -/- . (shrink)

Monkeypox, an infectious disease caused by the Orthopoxvirus, was identified in humans in 1970. It has recently emerged as a global health concern due to outbreaks beyond its endemic regions in Central and West Africa. This review examines the current state of medical treatments for monkeypox as of 2024, focusing on antiviral agents, immunotherapies, and supportive care measures. Monkeypox manifests with symptoms including fever, rash, and lymphadenopathy, with severe cases more common in immunocompromised individuals. Antiviral therapies such as tecovirimat and (...) brincidofovir are central to treatment strategies, with tecovirimat demonstrating efficacy in alleviating symptoms and reducing viral shedding. Emerging treatment strategies involve novel lipid-based formulations and combination therapies that integrate antivirals with immune-modulating agents. Supportive care remains essential, involving analgesics and antibiotics for secondary infections, while the MVA-BN vaccine plays a critical role in prevention. Research emphasizes the need for a deeper understanding of viral pathogenesis and host immune responses to improve therapeutic and preventive measures. Despite significant advancements, challenges remain, including potential antiviral resistance, disparities in healthcare access, and the necessity for enhanced diagnostic and surveillance capabilities. This review highlights the imperative for ongoing research, international collaboration, and investment in healthcare infrastructure to advance the management and prevention of monkeypox and to prepare for future outbreaks. (shrink)

Do other earthly forms of life evolved to the level of intelligent life? Cancer and resistance to antibiotics obliged to ask this question. Signs of intelligence are found at its simplest levels. We try to see if logic is used at these levels. Peter of Spain’s suppositio materialis is applied to the chemical signals of cells. Dynamic Logic is used to understand these chemical communications. <System of communications> is used, instead of “language”. The development of life appears as the (...) development of an axiomatic system. The rights of unborn humans and God’s rights over His own creation appear as the most powerful arguments for conservationism. (shrink)

The scope and type of property rights recognized over the effectiveness of antibiotics have a direct effect on how those claiming ownership engage in the exploitation and stewardship of this scarce resource. We examine the different property claims and rights the four major interest groups are asserting on antibiotics: (i) the inventors, (ii) those demanding that the resource be treated like any other transferable commodity, (iii) those advocating usage restrictions based on good stewardship principles and (iv) those considering the resource (...) as common heritage of humankind. (shrink)

Beliefs can be resistant to evidence. Nonetheless, the orthodox view in epistemology analyzes beliefs as evidence-responsive attitudes. I address this tension by deploying analytical tools on capacities and masking to show that the cognitive science of evidence-resistance supports rather than undermines the orthodox view. In doing so, I argue for the claim that belief requires the capacity for evidence-responsiveness. More precisely, if a subject believes that p, then they have the capacity to rationally respond to evidence bearing on p. (...) Because capacities for evidence-responsiveness are fallible and may be masked, beliefs can be held in the face of counter-evidence. Indeed, I will argue that our best science of belief supports the claim that evidence-resistant beliefs result from masks on evidence-responsiveness capacities. This account of belief not only allows for resistance to evidence, but provides us with a framework for describing and explaining actual cases of evidence-resistance. (shrink)

Imaginative resistance refers to a phenomenon in which people resist engaging in particular prompted imaginative activities. On one influential diagnosis of imaginative resistance, the systematic difficulties are due to these particular propositions’ discordance with real-world norms. This essay argues that this influential diagnosis is too simple. While imagination is indeed by default constrained by real-world norms during narrative engagement, it can be freed with the power of genre conventions and expectations.

We experience resistance when we are engaging with fictional works which present certain (for example, morally objectionable) claims. But in virtue of what properties do sentences trigger this ‘imaginative resistance’? I argue that while most accounts of imaginative resistance have looked for semantic properties in virtue of which sentences trigger it, this is unlikely to give us a coherent account, because imaginative resistance is a pragmatic phenomenon. It works in a way very similar to Paul Grice's (...) widely analysed ‘conversational implicature’. (shrink)

Readers of fictions sometimes resist taking certain kinds of claims to be true according to those fictions, even when they appear explicitly or follow from applying ordinary principles of interpretation. This "imaginative resistance" is often taken to be significant for a range of philosophical projects outside aesthetics, including giving us evidence about what is possible and what is impossible, as well as the limits of conceivability, or readers' normative commitments. I will argue that this phenomenon cannot do the theoretical (...) work that has been asked of it. Resistance to taking things to be fictional is often best explained by unfamiliarity with kinds of fictions than any representational, normative, or cognitive limits. With training and experience, any understandable proposition can be made fictional and be taken to be fictional by readers. This requires a new understanding both of imaginative resistance, and what it might be able to tell us about topics like conceivability or the bounds of possibility. (shrink)

In this paper, we clarify, unpack, and ultimately resist what is perhaps the most prominent argument for the compatibility of free will and determinism: the epistemic argument for compatibilism. We focus on one such argument as articulated by David Lewis: (i) we know we are free, (ii) for all we know everything is predetermined, (iii) if we know we are free but for all we know everything is predetermined, then for all we know we are free but everything is predetermined, (...) (iv) if for all we know we are free but predetermined, then it is really possible that we are, so (v) compatibilism. We uncover how the crucial epistemic modality underlying (iv) must be understood, and contend that, understood this way, the libertarian can resist (iv). Importantly, however, resisting the argument does commit the libertarian to what has been called “flip-flopping”—but we argue that this is perfectly coherent. We conclude by articulating two crucially ways the libertarian can resist the argument, by saying that we can know that determinism is false "from the armchair". (shrink)

This essay proposes a new way to read José Martí's idea of "Nuestra América," one that focuses on the mode of the call for unity toward liberation and decoloniality. In particular, I offer the arguments for this Latin American unity that would define a collective form of resistance against our colonial past and present (Europe) and an imperialist future (USA). It can be argued that it is extremely difficult to translate the Cuban author's thought by itself to our contemporary (...) struggles, and that this notion runs the risk of being an outdated, naïve, and even detrimental reduction of a too complex racial reality. In this essay, I defend a way in which this notion is still relevant today by alluding to the mode of a decolonial return to one's own land in the works of Édouard Glissant and Gloria Anzaldúa. In these two authors I see elements of the criticism of a colonial rootedness and filiation, linking a decolonial attitude toward the land with a particular way of returning to it: one that challenges a mythical, pure territorial space, and also reimagines the temporality of the return by focusing on the present. With the help of this novel gesture of returning to the land, I argue that Martí's nuestra América voices a call for unity and independence that still has value beyond its undeniable shortcomings. (shrink)

Imaginative resistance refers to a phenomenon in which people resist engaging in particular prompted imaginative activities. Philosophers have primarily theorized about this phenomenon from the armchair. In this paper, we demonstrate the utility of empirical methods for investigating imaginative resistance. We present two studies that help to establish the psychological reality of imaginative resistance, and to uncover one factor that is significant for explaining this phenomenon but low in psychological salience: genre. Furthermore, our studies have the methodological (...) upshot of showing how empirical tools can complement the predominant armchair approach to philosophical aesthetics. (shrink)

People seem more divided than ever before over social and political issues, entrenched in their existing beliefs and unwilling to change them. Empirical research on mechanisms driving this resistance to belief change has focused on a limited set of well-known, charged, contentious issues and has not accounted for deliberation over reasons and arguments in belief formation prior to experimental sessions. With a large, heterogeneous sample (N = 3,001), we attempt to overcome these existing problems, and we investigate the causes (...) and consequences of resistance to belief change for five diverse and less contentious socio-political issues. After participants chose initially to support or oppose a given socio-political position, they were provided with reasons favoring their chosen position (affirming reasons), reasons favoring the other, unchosen position (conflicting reasons), or all reasons for both positions (reasons for both sides). Our results indicate that participants are more likely to stick with their initial decisions than to change them no matter which reasons are considered, and that this resistance to belief change is likely due to a motivated, biased evaluation of the reasons to support their initial beliefs (prior-belief bias). More specifically, they rated affirming reasons more favorably than conflicting reasons—even after accounting for reported prior knowledge about the issue, the novelty of the reasons presented, and the reported strategy used to make the initial decision. In many cases, participants who did not change their positions tended to become more confident in the superiority of their positions after considering many reasons for both sides. (shrink)

The social categories to which we belong—Latino, disabled, American, woman— causally influence our lives in deep and unavoidable ways. One might be pulled over by police because one is Latino, or one might receive a COVID vaccine sooner because one is American. Membership in these social categories most often falls outside of our control. This paper argues that membership in social categories constitutes a restriction on human agency, creating a situation of non-ideal agency for many human individuals. -/- However, there (...) are ways to resist the causal influence of social categories, and certain socially marginalized groups can be understood as attempting to do just this. I discuss two instances of social category resistance: gender pronouns and the rights of trans individuals. I suggest that the intentional declaration of gender pronouns (“she/her” or “they/them”) can be understood as an attempt to resist the causal powers of nonconsensual social categorization. Similarly, one among many reasons to support the rights of trans individuals is that their self-declarations of gender identity can be viewed as a reclamation of agency in the face of causal constraints imposed by socially defined and imposed gender categories. This lesson can be generalized to people belonging to a broad range of marginalized groups. (shrink)

In this chapter, we evaluate the politically generative dynamic of urban space. Notably, we put forward the notion of the ‘multiplier effect’ of the urban, referring to its ingrained tendency to multiply resistance to oppression and violence being exerted against subaltern groups and minorities and, in doing so, to turn this multiplied resistance into an active force of social change. We, therefore, look at the twofold valence of ‘resistance’: negative and affirmative. Resistance initially takes form as (...) a defensive response to oppression and violence. When this happens, the urban becomes the living platform for a multiplying dynamic of encounter and, potentially, of inter-group solidarity, thus laying the foundations for a cooperative – rather than competitive, as in neoliberal rationality, or inimical, as in national-populist reason – way of ‘being together’. After having developed this argument against the backdrop of the women’s movement in Tehran and the urban disobedience to anti-immigration policies in Italy, our chapter concludes by reflecting on the multiplier effect of urban resistance within the current context of national revanchism. (shrink)

Abstract: In this research, an Artificial Neural Network (ANN) model was developed and tested to predict efficiency of antibiotics in treating various bacteria types. Attributes that were taken in account are: organism name, specimen type, and antibiotic name as input and susceptibility as an output. A model based on one input, one hidden, and one output layers concept topology was developed and trained using a data from Queensland government's website. The evaluation shows that the ANN model is capable of (...) correctly predicting the susceptibility of organisms to the antibiotics with 98% accuracy. -/- . (shrink)

The problem of imaginative resistance holds interest for aestheticians, literary theorists, ethicists, philosophers of mind, and epistemologists. We present a somewhat opinionated overview of the philosophical discussion to date. We begin by introducing the phenomenon of imaginative resistance. We then review existing responses to the problem, giving special attention to recent research directions. Finally, we consider the philosophical significance that imaginative resistance has—or, at least, is alleged to have—for issues in moral psychology, theories of cognitive architecture, and (...) modal epistemology. (shrink)

I defend the view that the experience of resistance gives us a direct phenomenal access to the mind-independence of perceptual objects. In the first part, I address a humean objection against the very possibility of experiencing existential mind-independence. The possibility of an experience of mind-independence being secured, I argue in the second part that the experience of resistance is the only kind of experience by which we directly access existential mind-independence.

What reasons stand in favor of (or against) violent resistance to oppression? I distinguish two kinds of normative reasons that bear relevantly in such a practical deliberation. I argue that in addition to reasons of impartial morality, victims’ personal projects and relationships may also provide reasons for (or against) violent resistance. Moreover, there is no guarantee that conflicts will not occur between such reasons. Thus, some acts of violent resistance may arise from situations of radical choice in (...) which impartial moral reasons and personal reasons pull the agent in opposite directions. Regardless of what we ultimately think agents facing such decisions ought to do all things considered, recognizing such conflicts is crucial for understanding the circumstances that give rise to violence and for better sympathizing with victims who are pushed to such extreme modes of resistance. (shrink)

With the advance of CRISPR technology, parents will be tempted to create superior offspring who are healthier, smarter, and stronger. In addition to the fact that many of these procedures are considered immoral for Catholics, they could change human nature in radical and possibly disastrous ways. This article focuses on the question of human perfectionism. First, by considering the relationship between human nature and technology, it analyzes whether such advances can improve human nature in addition to curing diseases. Next, it (...) looks at the moral and spiritual dimensions of perfection by analyzing the cardinal virtues. It argues that seeking perfection in the physical sense alone may not be prudent or wise and may produce greater injustices and weaken the human spirit in the long run. Understanding our true calling to perfection can help us resist the temptation of hubris to enhance the human race through technology. (shrink)

Frederick Douglass, in his first autobiography, Narrative of the Life of Frederick Douglass, describes how his sociopolitical identity was scripted by the white other and how his spatiotemporal existence was likewise constrained through constant surveillance and disciplinary dispositifs. Even so, Douglass was able to assert his humanity through creative acts of resistance. In this essay, I highlight the ways in which Douglass refused to accept the other-imposed narrative, demonstrating with his life the truth of his being—a human being unwilling (...) to be classified as thing or property. As I engage selected passages and key events from Douglass's narrative, I likewise explore the ways in which the resistance tactics. (shrink)

Linda Martín Alcoff and others have emphasised that the discipline of philosophy suffers from a ‘demographic problem’. The persistence of this problem is partly the consequence of various forms of resistance to efforts to address the demographic problem. Such resistance is complex and takes many forms and could be responded to in different ways. In this paper, I argue that our attempts to explain and understand the phenomenon of resistance should use a kind of explanatory pluralism that, (...) following Quassim Cassam, I call multidimensionalism. I describe four general kinds of resistance and consider varying explanations, focusing on those focused on vices and social structures. I argue that vice-explanations and structural- explanations are both mutually consistent and mutually entailing. If so, there is no need to choose between vice explanations and structural explanations or any other kinds of explanation. We can and should be multidimensionalists: using many together is better. (shrink)

In evolutionary medicine and other related fields, the concept of evolutionary mismatch is used to explain phenomena whereby traits reduce in adaptive value and eventually become maladaptive as the environment changes. This article argues that there is a similar problem of persistent adaptivity—what has been called the problem of evolutionary novelty—and it introduces the concept of mismatch resistance in order to explain phenomena whereby traits retain their adaptive value in novel environments that are radically different from the organisms’ environment (...) of evolutionary adaptedness (EEA). The possible role of variability selection in the evolution of mismatch-resistant traits is discussed, and it is suggested that mismatch resistance provides a useful tool for making progress on certain issues related to evolutionary theory, such as the modularity debate, cases of adaptivity outside of organisms’ ancestral environment, and the viability of naturalism as an overarching philosophical framework for understanding the natural world. (shrink)