The presence of symmetries in physical theories implies a pernicious form of underdetermination. In order to avoid this theoretical vice, philosophers often espouse a principle called Leibniz Equivalence, which states that symmetry-related models represent the same state of affairs. Moreover, philosophers have claimed that the existence of non-trivial symmetries motivates us to accept the Invariance Principle, which states that quantities that vary under a theory’s symmetries aren’t physically real. Leibniz Equivalence and the Invariance Principle are often seen as part of (...) the same package. I argue that this is a mistake: Leibniz Equivalence and the Invariance Principle are orthogonal to each other. This means that it is possible to hold that symmetry-related models represent the same state of affairs whilst having a realist attitude towards variant quantities. Various arguments have been presented in favour of the Invariance Principle: a rejection of the Invariance Principle is inter alia supposed to cause indeterminism, undetectability or failure of reference. I respond that these arguments at best support Leibniz Equivalence. (shrink)

The distinction between dimensions and units in physics is commonplace. But are dimensions a feature of reality? The most widely-held view is that they are no more than a tool for keeping track of the values of quantities under a change of units. This anti-realist position is supported by an argument from underdetermination: one can assign dimensions to quantities in many different ways, all of which are empirically equivalent. In contrast, I defend a form of dimensional realism, on which some (...) assignments of dimensions to quantities better describe reality than others. The argument I provide is a form of inference to the best explanation. In particular, the technique of dimensional analysis is explanatory, but it is only successful for certain systems of dimensions. Since these dimensional systems support scientific explanations, we have reason to believe that they are real. (shrink)

Exposome research is put forward as a major tool for solving the nature-versus-nurture debate because the exposome is said to represent “the nature of nurture.” Against this influential idea, we argue that the adoption of the nature-versus-nurture debate into the exposome research program is a mistake that needs to be undone to allow for a proper bioethical assessment of exposome research. We first argue that this adoption is originally based on an equivocation between the traditional nature-versus-nurture debate and a debate (...) about disease prediction/etiology. Second, due to this mistake, exposome research is pushed to adopt a limited conception of agential control that is harmful to one's thinking about the good that exposome research can do for human health and wellbeing. To fully excise the nature-versus-nurture debate from exposome research, we argue that exposome researchers and bioethicists need to think about the exposome afresh from the perspective of actionability. We define the concept of actionability and related concepts and show how these can be used to analyze the ethical aspects of the exposome. In particular, we focus on refuting the popular “gun analogy” in exposome research, returning results to study participants and risk-taking in the context of a well-lived life. (shrink)

Ruetsche ([2011]) argues that the occurrence of unitarily inequivalent representations in quantum theories with infinitely many degrees of freedom poses a novel interpretational problem. According to Ruetsche, such theories compel us to reject the so-called ideal of pristine interpretation; she puts forward the ‘coalescence approach’ as an alternative. In this paper I offer a novel defence of the coalescence approach. The defence rests on the claim that the ideal of pristine interpretation already fails before one considers the peculiarities of QM∞: (...) there are pre-QM∞ parallels to coalescence. Despite this departure from pristinism, the ‘modest’ view that emerges poses no threat to scientific realism. (shrink)

In recent years, exposome research has been put forward as the next frontier for the study of human health and disease. Exposome research entails the analysis of the totality of environmental exposures and their corresponding biological responses within the human body. Increasingly, this is operationalized by big-data approaches to map the effects of internal as well as external exposures using smart sensors and multiomics technologies. However, the ethical implications of exposome research are still only rarely discussed in the literature. Therefore, (...) we conducted a systematic review of the academic literature regarding both the exposome and underlying research fields and approaches, to map the ethical aspects that are relevant to exposome research. We identify five ethical themes that are prominent in ethics discussions: the goals of exposome research, its standards, its tools, how it relates to study participants, and the consequences of its products. Furthermore, we provide a number of general principles for how future ethics research can best make use of our comprehensive overview of the ethical aspects of exposome research. Lastly, we highlight three aspects of exposome research that are most in need of ethical reflection: the actionability of its findings, the epidemiological or clinical norms applicable to exposome research, and the meaning and action–implications of bias. (shrink)

Background: Exposomics, the study of the exposome, is flourishing, but the field is not well defined. The term “exposome” refers to all environmental influences and associated biological responses throughout the lifespan. However, this definition is very similar to that of the term “environment”—the external elements and conditions that surround and affect the life and development of an organism. Consequently, the exposome seems to be nothing more than a synonym for the environment, and exposomics a synonym for environmental research. As a (...) result, some have rebranded their “standard” environmental health research with the neologistic exposome term, whereas others ignore or seek to abandon the seemingly redundant concept of the exposome. -/- Objectives: We argue that exposomics needs to sharpen its mission focus to counteract this apparent redundancy. Exposomics should be defined as a research program in environmental health aimed at enabling a comprehensive and discovery-driven approach to identifying environmental determinants of human health. Similar to the aim of the Human Genome Project, exposomics aims to analyze the complete complexity of exposures and their corresponding biological responses. Exposomics’ primary premise is that the existence of undiscovered, potentially interconnected, nongenetic (environmental) risk factors for health necessitates a comprehensive discovery-driven analysis approach. -/- Discussion: We argue that exposomics researchers should adopt our reconceptualization of exposomics and focus on the productiveness and integrity of their research program: its purpose and principles. We suggest that exposomics researchers should coordinate the writing of reviews that assess the program’s productiveness and integrity, as well as provide a platform for exposomics researchers to define their vision for the field. (shrink)

It is now standard to interpret symmetry-related models of physical theories as representing the same state of affairs. Recently, a debate has sprung up around the question when this interpretational move is warranted. In particular, Møller-Nielsen :1253–1264, 2017) has argued that one is only allowed to interpret symmetry-related models as physically equivalent when one has a characterisation of their common content. I disambiguate two versions of this claim. On the first, a perspicuous interpretation is required: an account of the models’ (...) common ontology. On the second, stricter, version of this claim, a perspicuous formalism is required in addition: one whose mathematical structures ‘intrinsically’ represent the physical world, in the sense of Field. Using Dewar’s :485–521, 2019) distinction between internal and external sophistication as a case study, I argue that the second requirement is decisive. This clarifies the conditions under which it is warranted to interpret symmetry-related models as physically equivalent. (shrink)

Recently, Dewar (2019) has suggested that one can apply the strategy of 'sophistication' - as exemplified by sophisticated substantivalism as a response to the diffeomorphism invariance of General Relativity - to gauge theories such as electrodynamics. This requires a shift to the formalism of fibre bundles. In this paper, I develop and defend this suggestion. Where my approach differs from previous discussions is that I focus on the metaphysical picture underlying the fibre bundle formalism. In particular, I aim to affirm (...) the physical reality of gauge properties. I argue that this allows for a local and separable explanation of the Aharonov-Bohm effect. Its puzzling features are explained by a form of holism inherent to fibre bundles. (shrink)

Shifts are a well-known feature of the literature on spacetime symmetries. Recently, discussions have focused on so-called dynamic shifts, which by analogy with static and kinematic shifts enact arbitrary linear accelerations of all matter (as well as a change in the gravitational potential). But in mathematical formulations of these shifts, the analogy breaks down: while static and kinematic shift act on the matter field, the dynamic shift acts on spacetime structure instead. I formulate a different, `active' version of the dynamic (...) shift which does act on matter. (shrink)

Physics presents us with a symphony of natural constants: G, h, c, etc. Up to this point, constants have received comparatively little philosophical attention. In this paper I provide an account of dimensionful constants, in particular the gravitational constant. I propose that they represent inter-quantity structure in the form of relations between quantities with different dimensions. I use this account of G to settle a debate over whether mass scalings are symmetries of Newtonian Gravitation. I argue that they are not, (...) but only if we interpret mass anti-quidditistically. This is analogous to anti-haecceitism in the presence of spacetime symmetries. (shrink)

This paper addresses Joseph Heath’s attempt to derive moral obligations from the conditions that are specified by the model of the perfectly competitive market. Through his market failures approach to business ethics he argues that firms should behave as if they are operating in a perfectly competitive market. However, I argue that this derivation of moral obligations runs counter to the metaethical principle that moral actions need to be voluntarily chosen from a set of alternatives. To the extent that Milton (...) Friedman’s derivation follows the same lines, my objection is also applicable to his approach to business ethics. I bring out the fact that the conditions required by the model of the perfectly competitive market cannot be realized in the actual world and argue that this causes problems for any moral obligations that might follow. My objection is illustrated by an intuitive example of someone set to an impossible task. I also bring in a way that Heath could work around this objection, but I argue that this would imply the collapse of his approach into another kind of theory that he wishes to distinguish himself from. More deeply, I show that my metaethical objection has epistemological consequences that undermine the very basis of the model of the perfectly competitive market. I conclude by stating that we need a different conception of competition, pointing to the facts that such a perspective would need to take into account, and suggesting that the concept of rivalry is up to the job. (shrink)

It is often claimed that one can avoid the kind of underdetermination that is a typical consequence of symmetries in physics by stipulating that symmetry-related models represent the same state of affairs (Leibniz Equivalence). But recent commentators (Dasgupta 2011; Pooley 2021; Pooley and Read 2021; Teitel 2021a) have responded that claims about the representational capacities of models are irrelevant to the issue of underdetermination, which concerns possible worlds themselves. In this paper I distinguish two versions of this objection: (1) that (...) a theory’s formalism does not (fully) determine the space of physical possibilities, and (2) that the relevant notion of possibility is not physical possibility. I offer a refutation of each. (shrink)

Although physical theories routinely posit absolute quantities, such as absolute position or intrinsic mass, it seems that only comparative quantities such as distance and mass ratio are observable. But even if there are in fact only distances and mass ratios, the success of absolutist theories means that the world looks just as if there are absolute positions and intrinsic masses. If comparativism is nevertheless true, there is a sense in which this is a cosmic conspiracy: the comparative quantities satisfy certain (...) relations that only absolutism can explain. I show that such cosmic conspiracies are a pervasive feature of comparativist theories. The argument is structurally similar to the well-known No Miracles Argument for scientific realism. Just as anti-realism cannot explain the empirical adequacy of our theories in general, so comparativism cannot explain the empirical adequacy of absolutist theories in particular. (shrink)

The infamous Hole Argument has led philosophers to develop various versions of substantivalism, of which metric essentialism and sophisticated substantivalism are the most popular. In this journal, Trevor Teitel has recently advanced novel arguments against both positions. However, Teitel does not discuss the position of Jeremy Butterfield, which appeals to Lewisian counterpart theory in order to avoid the Hole Argument. In this note I show that the Lewis-Butterfield view is immune to Teitel’s challenges.

We start by presenting three different views that jointly imply that every person has many conscious beings in their immediate vicinity, and that the number greatly varies from person to person. We then present and assess an argument to the conclusion that how confident someone should be in these views should sensitively depend on how massive they happen to be. According to the argument, sometimes irreducibly de se observations can be powerful evidence for or against believing in metaphysical theories.

Female crested gibbons (genus Nomascus) perform conspicuous sequences of twitching movements involving the rump and extremities. However, these dances have attracted little scientific attention and their structure and meaning remain largely obscure. Here we analyse close-range video recordings of captive crested gibbons, extracting descriptions of dance in four species (N. annamensis, N. gabriellae, N. leucogenys and N. siki). In addition, we report results from a survey amongst relevant professionals clarifying behavioural contexts of dance in captive and wild crested gibbons. Our (...) results demonstrate that dances in Nomascus represent a common and intentional form of visual communication restricted to sexually mature females. Whilst primarily used as a proceptive signal to solicit copulation, dances occur in a wide range of contexts related to arousal and/or frustration in captivity. A linguistically informed view of this sequential behaviour demonstrates that movement within dances is organized in groups and follows an isochronous rhythm — patterns not described for visual displays in other non-human primates. We argue that applying the concept of dance to gibbons allows us to expand our understanding of communication in non-human primates and to develop hypotheses on the rules and regularities characterising it. We propose that crested gibbon dances likely evolved from less elaborate rhythmic proceptive signals, similar to those found in siamangs. Although dance displays in humans and crested gibbons share a number of key characteristics, they cannot be assumed to be homologous. Nevertheless, gibbon dances represent a striking model behaviour to investigate the use of complex gestural signals in hominoid primates. (shrink)

Suppose that an altruistic agent who is uncertain between evidential and causal decision theory finds herself in a situation where these theories give conflicting verdicts. We argue that even if she has significantly higher credence in CDT, she should nevertheless act in accordance with EDT. First, we claim that the appropriate response to normative uncertainty is to hedge one's bets. That is, if the stakes are much higher on one theory than another, and the credences you assign to each of (...) these theories are not very different, then it is appropriate to choose the option that performs best on the high-stakes theory. Second, we show that, given the assumption of altruism, the existence of correlated decision makers will increase the stakes for EDT but leave the stakes for CDT unaffected. Together these two claims imply that whenever there are sufficiently many correlated agents, the appropriate response is to act in accordance with EDT. (shrink)

This article examines Hegel’s aesthetic judgment of the German romantic painter Caspar David Friedrich, which only first came to light in 1995 with the publication of the separate edition of the Ascheberg transcript of Hegel’s first lecture course on aesthetics, held at the University of Berlin in the winter semester of 1820/21. Firstly, before interpreting Hegel's criticism in more detail, I consider the current state of research on the relationship between Hegel and Caspar David Friedrich. It is striking (...) to note how little resonance Hegel’s judgment has found in the secondary literature. Going beyond some of the more speculative results of earlier scholarship, I show that by consulting a number of overlooked original German sources and documents from the years 1820-1821 it is possible to precisely determine those paintings of Caspar David Friedrich that Hegel would have known about and even viewed in person at that time. By comparing Hegel’s criticism in the Ascheberg transcript with these particular paintings of Friedrich viewed by Hegel in Dresden, and by furthermore reading this criticism in the larger context of Hegel's considerations on style and the topic of mysteriousness in painting, I argue that a number of consequences can be drawn from the philosopher’s two key reproaches of severity and affectation that are significant for both Hegel scholarship and Caspar David Friedrich research. (shrink)

Cet ouvrage oriente la réflexion philosophique sur le romantisme allemand dans une voie nouvelle ayant pour point de départ la singularité des paysages peints par Caspar David Friedrich, et pour concept opératoire majeur la romantisation du monde, dont Novalis a fait le programme d’une philosophie spécifique. Analyser la critique par Hegel du style de Friedrich ; étudier l’invention par Novalis, dans le prolongement de Herder, de quelque chose comme un paysage-corps ; suivre au-delà de Kant le destin du concept (...) de sublime : tels sont les moments principaux d’un parcours qui permet de mettre au jour les liens existant entre la peinture de Friedrich et la problématique de la « révélation » énoncée par Novalis dans ses fragments sur la philosophie romantique. (shrink)

Ernst Mayr argued that the emergence of biology as a special science in the early nineteenth century was possible due to the demise of the mathematical model of science and its insistence on demonstrative knowledge. More recently, John Zammito has claimed that the rise of biology as a special science was due to a distinctive experimental, anti-metaphysical, anti-mathematical, and anti-rationalist strand of thought coming from outside of Germany. In this paper we argue that this narrative neglects the important role played (...) by the mathematical and axiomatic model of science in the emergence of biology as a special science. We show that several major actors involved in the emergence of biology as a science in Germany were working with an axiomatic conception of science that goes back at least to Aristotle and was popular in mid-eighteenth-century German academic circles due to its endorsement by Christian Wolff. More specifically, we show that at least two major contributors to the emergence of biology in Germany—Caspar Friedrich Wolff and Gottfried Reinhold Treviranus—sought to provide a conception of the new science of life that satisfies the criteria of a traditional axiomatic ideal of science. Both C.F. Wolff and Treviranus took over strong commitments to the axiomatic model of science from major philosophers of their time, Christian Wolff and Friedrich Wilhelm Joseph Schelling, respectively. The ideal of biology as an axiomatic science with specific biological fundamental concepts and principles thus played a role in the emergence of biology as a special science. (shrink)

The theories of pre-existence and epigenesis are typically taken to be opposing theories of generation in the seventeenth and eighteenth centuries. One can be a pre-existence theorist only if one does not espouse epigenesis and vice versa. It has also been recognized, however, that the line between pre-existence and epigenesis in the nineteenth century, at least, is considerably less sharp and clear than it was in earlier centuries. The debate (1759-1777) between Albrecht von Haller and Caspar Friedrich Wolff on (...) their theories of generation is usually taken to be a debate between a pre-existence theorist and an epigeneticist, and the supposed fact that these two theories of generation are mutually exclusive explains (so the story goes) the divide between Haller and Wolff. However, it’s not clear that Haller endorsed an especially robust form of pre-existence, and nor is it clear that Wolff’s theory of generation -- once he considered it carefully -- is clear epigenetic. Rather, Haller’s theory of generation is marked by traces of epigensis and Wolff’s theory has elements of pre-existence theory. This is not to say that their theories of generation are basically the same, but the debate between the two ought not to be framed in terms of pre-existence versus epigenesis. Their points of difference must be explained in some other way. In this way, their controversy bears characteristics of similar disputes over generation in the nineteenth century more than it resembles those in the seventeenth century. In this paper, I argue that (a) Haller’s and Wolff’s theories both blend elements from pre-existence and epigenesis; (b) but there are still deeply-rooted differences between the two generation theories; (c) one source of these differences is that Haller and Wolff have divergent conceptions of what an adequate explanation is; (d) we can see that they have different conceptions of what constitutes an adequate explanation by paying heed to their evaluations of Descartes’ epistemology and methodology in his theory of generation (such as it is); and (e) this shows that one of the main differences between Haller’s generation theory and that of Wolff is the degree to which each thinks we need to (and indeed can) explain the nature of the causes -- both efficient and final -- at play during the formation of organic beings. (shrink)

The results of empirical research show that people prefer to help identified individuals rather than unidentified ones. This preference has an important influence on many private and public decisions, for example concerning vaccination or the distribution of healthcare resources. The aim of this article is to define the terms: “identified”, “unidentified”, “statistical”, and then to analyze three philosophical arguments concerning the normative implications of this preference: 1) contractualism ex ante ; 2) fair distribution of chances and risks; 3) principles regarding (...) the concentration of good effects and the distribution of bad effects. I will demonstrate that these arguments, which are related to interesting philosophical problems, such as counterfactuals, are not convincing. (shrink)

This paper defends the view that one's own mental states are metaphysically privileged vis-à-vis the mental states of others, even if only subjectively so. This is an instance of a more general view called Subjectivism, according to which reality is only subjectively the way it is. After characterizing Subjectivism in analogy to two relatively familiar views in the metaphysics of modality and time, I compare the Subjectivist View of the Mental with Egocentric Presentism, a version of Subjectivism recently advocated by (...) Caspar Hare. I argue that the Subjectivist View of the Mental goes a considerable way towards solving certain long-standing philosophical puzzles having to do with the unity of consciousness, the contents of self-awareness and the intransmissibility of experiential knowledge through testimony. (shrink)

The characterization of objective, normative reasons to φ as facts (or truths) that count in favor of φ-ing is widely accepted. But are there any further conditions that considerations which count in favor of φ-ing must meet, in order to count as a reason to φ? In this brief paper, I consider and reject one such condition, recently proposed by Caspar Hare.

This article considers how Portuguese cinema questions the possibility of any cinematic representation of national identity. By exposing the subjective mechanisms and the artistic construction of Manoel de Oliveira's Cristóvão Colombo, o enigma (2007), I argue that the film serves as a portrait despite being an affective landscape—what John Caspar Lavater has referred to as a physiognomic. Oliveira achieves this through the atemporal depiction of his own experience of the facts and fictions of Portuguese history. I also examine the (...) Wagnerian concept of Gesamtkunstwerk (" total art ") along with more recent conceptions of " impure cinema. ". (shrink)

Peter Harrison explains the disappearance of symbolic meanings of animals from seventeenth-century works in natural history through what he calls the “literalist mentality of the reformers.” By contrast, the present article argues in favor of a different understanding of the connection between hermeneutics and Protestant natural history. Martin Luther, Philipp Melanchthon, Johannes Brenz, Johannes Oecolampadius, and Jean Calvin continued to assign moral meanings to natural particulars, and moral interpretations can still be found in the writings of Protestant naturalists such as (...) Conrad Gesner, Caspar Heldelinus, Jeremias Wilde, Thomas Penny, and Thomas Moffett. If there are differences between Protestant and Catholic interpretations of animals, then these differences derive from the reformer’s greater insistence on providing textual support for assigning symbolic meanings, their resulting greater reluctance in assigning prophetic meanings to animals, and their elimination of spiritual interpretations of animals that are in tension with central tenets of Protestant theology. These differences in hermeneutics and theology may explain some of the divergences between the symbolic interpretations of animals proposed by Protestant natural historians and their Catholic colleague, Ulisse Aldrovandi. (shrink)

The introductory personal remarks refer to my motivations for choosing research projects, and for moving from physics to molecular biology and then to development, with Hydra as a model system. Historically, Trembley’s discovery of Hydra regeneration in 1744 was the begin¬ning of developmental biology as we understand it, with passionate debates about preformation versus de novo generation, mechanisms versus organisms. In fact, seemingly conflicting bottom-up and top-down concepts are both required in combination to understand development. In modern terms, this means (...) analysing the molecules involved, as well as searching for physical principles underlying development within systems of molecules, cells and tissues. During the last decade, molecular biology has provided surprising and impressive evidence that the same types of mol¬ecules and molecular systems are involved in pattern formation in a wide range of organisms, including coelenterates like Hydra, and thus appear to have been “invented” early in evolution. Likewise, the features of certain systems, especially those of developmental regulation, are found in many different organisms. This includes the generation of spatial structures by the interplay of self-enhancing activation and “lateral” inhibitory effects of wider range, which is a main topic of my essay. Hydra regeneration is a particularly clear model for the formation of defined patterns within initially near-uniform tissues. In conclusion, this essay emphasizes the analysis of development in terms of physical laws, including the application of mathematics, and insists that Hydra was, and will continue to be, a rewarding model for understanding general features of embryogenesis and regeneration. -/- -/- . (shrink)