Os minerais possuem uma influência direta em diversos processos fisiológicos no organismo animal e, mesmo com tamanha importância, por vezes são negligenciados pelos produtores para seu fornecimento para os animais. Este estudo teve como objetivo avaliar o desempenho reprodutivo de rebanhos de bovinos, caprinos e ovinos em 8 propriedades rurais nas cidades de Sanharó, Pesqueira, Arcoverde, Belo Jardim e São Bento do Una através da adição de suplemento mineral e mistura múltipla aos animais de forma a atender suas necessidades básicas (...) para mantença e reprodução. Foram avaliados os desempenhos de 4 touros e 25 vacas, 3 bodes e 50 cabras e 4 carneiros e 48 ovelhas em diferentes propriedades, avaliando como a adição de um suplemento mineral específico da espécie impacta de forma positiva nos índices reprodutivos avaliados que foram taxa de cio, taxa de serviço, taxa de concepção, taxa de fertilidade, taxa de prenhez, taxa de perdas gestacionais, taxa de natalidade e taxa de mortalidade. O experimento teve duração de 2 anos e pôde-se avaliar cerca de 2 partos nas vacas e, mais ou menos, 3 partos em cabras e ovelhas. Os dados foram computados e avaliados estatisticamente no Excel para conferir se os índices reprodutivos melhoraram em função da adição de minerais na ração dos animais. Conferiu-se que houve diferença significativa entre todos os índices avaliados, ou seja, a adição de minerais na ração dos animais melhora a eficiência reprodutiva de machos e fêmeas de animais ruminantes, sendo de suma importância sua disponibilização de forma correta para alcançar bons índices reprodutivos na fazenda na busca pela obtenção de neonatos que poderão ser comercializados. -/- REFERÊNCIAS BIBLIOGRÁFICAS ASTRO, G. B. A importância da adição de minerais na dieta de caprinos e ovinos no Agreste de Pernambuco. Trabalho de Conclusão de Curso (Técnico Subsequente em Agropecuária) - IFPE Campus Belo Jardim. Belo Jardim, 2023. 44 p. BALAMURUGAN, B. et al. Mineral an important nutrient for efficient reproductive health in dairy cattle. Int. J. Environ. Sci. Technol, v. 6, n. 1, p. 694-701, 2017. Barros NN, Bomfim MAD. Mistura múltipla para caprinos e ovinos. In: Anais VIII PECNORDESTE – Seminário Nordestino de Pecuária, 8; 2004; Fortaleza, Brasil. Fortaleza: FAEC, 2004. p. 50-57. BERCHIELLI, T. T.; PIRES, A. V.; OLIVEIRA, S. G. (Eds.). Nutrição de ruminantes. Jaboticabal: Funep, 2011. COTTA, T. Minerais e vitaminas para bovinos, ovinos e caprinos. Viçosa: Aprenda Fácil, 2001. DANTAS, C. C. O.; DE MATTOS NEGRÃO, F. Funções e sintomas de deficiência dos minerais essenciais utilizados para suplementação dos bovinos de corte. UNICiências, v. 14, n. 2, 2010. DA SILVA EIC. A água na nutrição animal. 1ª ed. Recife, PE: Instituto Agronômico de Pernambuco, 2023. DA SILVA, Emanuel Isaque Cordeiro. Cálculos de consumo e digestibilidade de alimentos e nutrientes para ruminantes. Revista Universitária Brasileira, v. 1, n. 3, 2023. DA SILVA, Emanuel Isaque Cordeiro. Concentrados e Rações Para Cabras em Lactação. 2022. DA SILVA, Emanuel Isaque Cordeiro. Efeitos da raça e do manejo nutricional sobre as características de qualidade da carcaça e da carne em ovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia da Reprodução de Bovinos Leiteiros: Aspectos Básicos e Clínicos. Emanuel Isaque Cordeiro da Silva, 2022. DA SILVA, Emanuel Isaque Cordeiro. Formulação de ração para caprinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação de ração para ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Avaliação de Suplemento Mineral Para Caprinos. Instrução Técnica Para o Produtor Rural de Pernambuco, v. 3, n. 1, p. 1-4, 2023. DA SILVA, Emanuel Isaque Cordeiro. Formulação e fabricação de rações para ruminantes. 1ª ed. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Fabricação de Rações Para Ruminantes: Bovinos, Caprinos e Ovinos. 2021. DA SILVA, Emanuel Isaque Cordeiro. Manejo Reprodutivo e Índices Zootécnicos em Gado de Leite. 2023. DA SILVA, Emanuel Isaque Cordeiro. Métodos de Formulação e Balanceamento de Rações para Bovinos. Belo Jardim: Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição e Suplementação Mineral de Bovinos de Corte. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. DA SILVA, Emanuel Isaque Cordeiro. Opções de concentrados para vacas em lactação no Semiárido. 2022. DA SILVA, Emanuel Isaque Cordeiro. Relação e Efeitos Bioquímico-nutricionais Sobre os Cistos Ovarianos em Vacas. DA SILVA, Emanuel Isaque Cordeiro. Relação e Efeitos Bioquímico-nutricionais Sobre os Transtornos do Ciclo Estral em Vacas. DA SILVA, E. I. C. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. DE MENDONÇA JÚNIOR, A. F. et al. Minerais: importância de uso na dieta de ruminantes. Agropecuária Científica no Semiárido, v. 7, n. 1, p. 01-13, 2011. DE PAULA SILVEIRA, L. Suplementação mineral para bovinos. Medicina Veterinária e Zootecnia, v. 11, n. 5, p. 489-500, 2017. FADLALLA, I. M. T. The Interactions of Some Minerals Elements in Health and Reproductive Performance of Dairy Cows. New Advances in the Dairy Industry, 2022. FERGUSON, J. D. Nutrition and reproduction in dairy cows. Veterinary clinics of North America: Food animal practice, v. 7, n. 2, p. 483-507, 1991. GALVANI, D. B.; BOMFIM, MAD. Mistura múltipla para caprinos e ovinos: nova fórmula dispensa adaptação. 2015. HAENLEIN, G. F. W.; ANKE, M. Mineral and trace element research in goats: A review. Small Ruminant Research, v. 95, n. 1, p. 2-19, 2011. KAWAS, J. R.; ANDRADE-MONTEMAYOR, H.; LU, C. D. Strategic nutrient supplementation of free-ranging goats. Small Ruminant Research, v. 89, n. 2-3, p. 234-243, 2010. KESSLER, J. Mineral nutrition of goats. In: Goat nutrition, v. 46, p. 104-119, 1991. LOPES, H. O. S. Suplementação de baixo custo para bovinos: mineral e alimentar. 1998. MANERA, D. B. et al. Mineral mixtures from solid salt residues for lambs. Revista Brasileira de Zootecnia, v. 43, p. 485-491, 2014. MASTERS, D. G. Practical implications of mineral and vitamin imbalance in grazing sheep. Animal Production Science, v. 58, n. 8, p. 1438-1450, 2018. MORAES, S. da S. Importância da suplementação mineral para bovinos de corte. Campo Grande, MS: Embrapa Gado de Corte, 2001., 2001. NICODEMO, M. L. F. et al. Minerais na eficiência reprodutiva de bovinos. 1ª ed. São Carlos: Embrapa Pecuária Sudeste, 2008. 50 p. NIX, J.. Trace minerals important for goat reproduction. Sweetlix Livestock Supplement System, 2002. NOGUEIRA, É. et al. Nutrição aplicada à reprodução de bovinos de corte. In: MEDEIROS, S. R. et al. (Eds.). Nutrição de bovinos de corte: fundamentos e aplicações. 1ª ed. Brasília: Embrapa, 2015. p. 143-156. PASA, C.. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2010. PEIXOTO, P. V. et al. Eficiência reprodutiva de matrizes bovinas de corte submetidas a três diferentes tipos de suplementação mineral. Pesquisa Veterinária Brasileira, v. 23, p. 125-130, 2003. PRADA, F. Influência da nutrição animal na reprodução de touros: revisão. Revista de Educação Continuada do CRMV-SP, v. 8, n. 1, p. 68-76, 2005. ROGÉRIO, M. C. P. et al. Manejo alimentar de caprinos e ovinos nos trópicos. Veterinária e Zootecnia, v. 23, n. 3, p. 326-346, 2016. SARTORI, R.; GUARDIEIRO, M. M. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. SHARMA, M. C. et al. Mineral nutrition and reproductive performance of the dairy animals: a review. The Indian Journal of Animal Sciences, v. 77, n. 7, 2007. SILVA, D. C. et al. Importância do uso de minerais na dieta de bovinos reprodutores. Vet. zootec, p. 38-52, 2018. SOUZA, G. V. Suplementação de minerais na reprodução de bovinos. Trabalho de Conclusão de Curso (Graduação em Zootecnia) - UFG. Jataí, 2014. 32 p. TEIXEIRA, J. C. Nutrição de ruminantes. Lavras: FAEPE, 1992. UNDERWOOD, E. J.; SUTTLE, N. F. Los minerales en la nutrición del ganado. 3ª ed. Zaragoza: Acribia, 2003. VALADARES FILHO, S. C. et al. (Eds.). Tabelas brasileiras de composição de alimentos para ruminantes. 1ª ed. Viçosa: UFV, 2015. VALENTIM, J. K. et al. Fatores nutricionais aplicados à reprodução de ruminantes. UNICIÊNCIAS, v. 23, n. 2, p. 77-82, 2019. VASCONCELOS, F. F. Suplementação mineral no manejo reprodutivo ovino. Dissertação (Mestrado em Medicina Veterinária) - Centro de Ciências Rurais, UFSM. Santa Maria, 2012. 50 p. VÁZQUEZ-ARMIJO, J. F. et al. Trace elements in sheep and goats reproduction: a review. Tropical and Subtropical Agroecosystems, v. 14, n. 1, p. 1-13, 2011. VELLADURAI, C.; SELVARAJU, M.; NAPOLEAN, R. E. Effects of macro and micro minerals on reproduction in dairy cattle a review. International Journal of Scientific Research in Science and Technology, v. 2, n. 1, p. 68-70, 2016. YASOTHAI, R. Importance of minerals on reproduction in dairy cattle. International Journal of Science, Environment and Technology, v. 3, n. 6, p. 2051-2057, 2014. (shrink)

RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE OS TRANSTORNOS DO CICLO ESTRAL DE VACAS -/- Emanuel Isaque Cordeiro da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim [email protected] ou [email protected] WhatsApp: (82)98143-8399 -/- •__6. Transtornos do ciclo estral -/- Qualquer alteração na frequência, duração ou intensidade do ciclo estral é considerada uma perturbação do ciclo, cujas origens variam etiologicamente. As perturbações do ciclo podem originar-se em qualquer das partes do eixo hipotálamo-hipófise-ovário (FRAZER, 2005; GORDON, 1996). Pode ou não ser do tipo (...) permanente e pode depender de sua origem, momento e intensidade cursar com outras alterações reprodutivas, por exemplo uma retenção do corpo lúteo, dá lugar a prolongamento da fase lútea, altos níveis de progesterona circulante e pode, finalmente, desencadear em um cisto luteal ou em uma metrite. Entre os fatores desencadeadores da falha do ciclo estral estão os fatores de origem nutricional, dentre eles: 6.1 Minerais 6.1.1 Relação Na:K (Sódio: Potássio) A deficiência de sódio pode causar distúrbios do ciclo estral, isto porque as células animais intracelularmente possuem uma alta concentração de K e uma baixa concentração de Na, esta relação pode chegar a 10:1 ou mais, em relação ao meio externo. Com esta relação, as concentrações intracelulares estão em equilíbrio com o meio externo. A absorção e secreção de cátions pela célula para conseguir o equilíbrio é simultânea, gerada por um sistema de transporte específico chamado "bomba Na-K". Se a nível celular não existe um balanço iônico de K:Na, a maior prioridade das células tubulares do rim é a de conseguir novamente um equilíbrio, o mecanismo destas células é o da reabsorção do íon que se encontre em excesso de água, diminuindo a quantidade deste no líquido para manter as funções em equilíbrio dinâmico. Os desequilíbrios não compensados a nível celular ou renal, levam a alterações na condutividade nervosa por alteração da bomba de transmissão elétrica. O ciclo estral é alterado por diminuir a expressividade dos sinais comportamentais de estro, que são produzidos por concentrações crescentes de estrogênio mas com alta necessidade de adequação nervosa para a exposição corporal do cio e a aceitação da monta. O potássio, em particular, desempenha um papel fundamental como coator em certas interações enzimáticas, incluindo a transferência de energia, a síntese de proteínas e o metabolismo de hidratos de carbono, em especial nos sistemas em que o ADP está envolvido, as hexoquinases e a anidrase carbônica. O sódio, por sua vez, é o principal cátion extracelular, regula o equilíbrio hídrico no organismo e a mecânica de fluidos, desta forma regula a pressão osmótica e a troca aquosa nos tecidos. Devido a esta função, um dos fatores importantes do fluxo Na:K é o rim, que é controlado pela aldosterona, a principal hormona reguladora da absorção de sódio e excreção de potássio. Qualquer desequilíbrio na relação Na:K, afetará o ciclo estral, de maneira direta e indireta, através da alteração na síntese de proteínas e da perda da regulação hídrica, fator importante pelas secreções que devem acompanhar as manifestações de cio/estro. 6.1.2 Relação Cobalto (Co) A deficiência de cobalto gera um efeito biológico determinado pela sua presença na molécula da vitamina B12, a qual regula a hematopoese (Ativa a síntese de protoporfirina) e afeta o metabolismo do nitrogênio e dos carboidratos. A vitamina B12 atua como uma coenzima da transmetilação (síntese do glutamato mutase, metilmalonil-CoA-Mutase, diol-dehidratase e redução dos ribonucleótidos a desoxirribonucleótidos, isomerização da a-lisina, etc.). Especialmente em ruminantes, a reação mutase da metilmalonina-CoA está relacionada com o metabolismo do ácido propiônico e, portanto, com a síntese de glicose e o equilíbrio energético. O cobalto também está envolvido na carboxilação da propionil-CoA à metilmalonil-CoA e na isomerização deste último para succinil-CoA. O metabolismo do ácido propiônico ocorre no fígado e é reduzido pelo fato do metilmalonil não poder ser convertido em succinil-CoA, impedindo a sua passagem para oxalacetato e glicose, gerando uma relação inversa entre os níveis de energia e proteína; causando uma diminuição de GnRH que afeta negativamente a liberação de LH que, por sua vez, cria um aumento na FSH. Isso produz uma anulação da ovulação e, consequentemente, ausência de um ciclo estral verdadeiro. Vale reforçar que, para prevenção da deficiência do cobalto, o criador pode optar pelo fornecimento de volumosos que dispõem de quantidades de cobalto que suprem as exigências dos animais, ou pela inserção de sais de cobalto à mistura da ração, sempre no intervalo sugerido de 0,07 e 0,11 mg/kg para cada animal, suprindo a necessidade do mesmo e garantindo assim a prevenção dos transtornos do ciclo estral ou outras afecções do sistema reprodutivo. 6.1.3 Relação Cobre (Cu) e Molibdênio (Mo) A deficiência de cobre gera, indiretamente, molibdênio, durante esse processo, tanto o macho como a fêmea são inférteis ou sub-férteis, mas, em geral, os transtornos surgem não por molibdeniose mas por hipocuprose condicionada por excesso de molibdênio nas pastagens e pelos sulfatos presentes na água de bebida (BREM, 2016). Isso leva à formação de tiomolibdato no rúmen, que por sua vez combina com o cobre para formar tiomolibdato de cobre, sal muito insolúvel. O tiomolibdato presente, formado em excesso e que não encontra cobre suficiente, contribuirá para produzir a diarreia, limitando ainda mais a absorção de cobre. A interferência mais importante do molibdênio ocorre no processo metabólico do cobre, interferindo sua atividade enzimática. O molibdênio atua sobre o complexo sulfeto-oxidase hepático. A enzima que está envolvida na oxidação de metabolitos sulfurados, reduz a sua atividade na presença de altos teores de molibdênio, especialmente quando a quantidade de cobre é baixa. Daqui resulta a formação de sulfureto de cobre, muito insolúvel e, portanto, pouco ou nada utilizável pelas células e/ou tecidos (QUIROZ-ROCHA & BOUDA, 2001). O excesso de molibdênio nas pastagens ou na água de bebida reduz a quantidade de cobre no fígado, mas para uma dada dose de molibdênio, esta redução é diretamente proporcional ao aumento dos sulfatos na ingestão, porque só na presença de sulfatos o molibdênio exerce sua ação limitante. O melhor modo de tratar o molibdênio e a ação dos sulfatos sobre o cobre, é aumentar a quantidade de cobre disponível pelos animais, seja por via bucal ou parenteral. Desta forma, há aumentos na cupremia e no ganho de peso. É conveniente, para o efeito, efetuar um controle dos resultados mediante a observação clínica, pesagem dos animais e análise de cobre no sangue. Isso permitirá estabelecer as doses ideais e adequadas para cada estabelecimento e efetuar um estudo econômico da suplementação (BAVERA, 2002). Como já foi tratado o requerimento do cobre para evitar os problemas reprodutivos das vacas, falemos do molibdênio (Mo). O Mo é um elemento primordial para bovinos leiteiros, uma vez que é componente de uma enzima presente no leite (xantina oxidasse). A deficiência de Mo a nível prático não foi relatada, porém casos podem acontecer. Para ovinos, que é uma espécie ruminante, a concentração exigida pelo animal em Mo presente na MS é de 5 a 10 mg/kg, porém deve levar em consideração a relação crítica entre o Mo e o Cu que deve ser no máximo 20 e nunca superior. O nível crítico de toxidade de Mo nos alimentos volumosos (forrageiras, gramíneas e leguminosas) não pode ultrapassar os 6% por kg de MS. Através de todos esses cuidados, o criador poderá obter sucesso tanto na prevenção contra os distúrbios do ciclo estral das vacas, quanto de outras complicações como toxidade, desnutrição, etc. 6.2 Relação energia:proteína Em relação ao aumento do consumo de proteína crua ou de deficiência de energia, aumenta-se a quantidade de ureia no sangue e produz-se uma toxicidade tecidular, afetando o endométrio e diminuindo a produção de prostaglandinas, que são as encarregadas de manter o corpo lúteo, caso não se mantenha acaba provocando um ciclo estral longo. A situação pode ser explicada a nível do eixo hipotálamo-hipófise, no qual os baixos níveis de glicose inibem a secreção de GnRH e resultam na diminuição da pulsatilidade da LH, seja por ação direta ou mediada através das ß-endorfinas. Outro fator que afeta o crescimento folicular é a nutrição, especificamente a perda da condição corporal, quando o animal não se alimenta direito ou quando se alimenta não tem uma condição balanceada que supra suas exigências nutricionais e que tenha um aceitável ganho de peso diário (GPD), acaba perdendo massa muscular ou de gordura, em outras palavras altera-se a condição corporal do mesmo, e se a perda for de 22 a 24 % de peso corporal (PC), os animais que perdem essa condição entram em anestro o que acaba tornando um animal inviável para a reprodução e também para o abate, uma vez que encontra-se fora do peso ideal. Tanto as proteínas quanto a energia foram tratados em trabalhos anteriores, porém nunca é tarde para salientar que ambas devem ser fornecidas em qualidade e quantidade que consiga favorecer ao desenvolvimento do animal e aos mecanismos fisiológicos do mesmo. 6.3 Fito-toxidade Finalmente, um fator adicional que induz a alteração da ciclicidade estral são os fitoestrógenos, plantas com altos teores de isoflavonas que possuem, no organismo animal, uma ação estrogênica. Os fitoestrógenos estão amplamente difundidos, nos trevos, alfafa, milho e nas pastagens de cultivo intensivo. Os fitoestrogênios são diferentes dos estrogênios produzidos pelo animal, mas a sua ação é idêntica nos receptores do trato reprodutivo; o seu metabolismo e excreção é diferente (por exemplo, desmetilização) e a sua excreção renal através dos glicoronosidos, assim mesmo a formação de ésteres sulfatos no tecido hepático é menor, acumulando-se em circulação e alterando a duração da fase estrogênica do ciclo, isso leva à ninfomania das vacas e com ela a perda da função reprodutiva. Deve-se estar atento ao pasto que se cultiva e ao solo em que se implanta o pasto, uma vez que o solo pode ter excessos de minerais prejudiciais ao animal e que o coloque em uma situação de toxidade, já que a planta absorve do solo o excesso e da planta vai para o animal por meio direto ou pela silagem. Um exemplo é o teor de molibdênio na planta que não pode ser maior que 6%, se for ocorrerá inúmeras transformações fisiológicas maléficas ao animal, que acabará sendo descartado do objetivo que seria a reprodução na fazenda. -/- Apoio -/- Realização -/- REFERÊNCIAS BIBLIOGRÁFICAS BAVERA, Guillermo Alejandro. Aguas y aguadas para el ganado. Rio Cuarto: Inter-Medica Editorial, 2009. BERCHIELLI, Telma Teresinha; PIRES, Alexandre Vaz; OLIVEIRA, SG de. Nutrição de ruminantes. Jaboticabal: funep, 2006. BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. BREM, J. J. et al. Alteraciones del ciclo estral provocadas por un alto ingreso de molibdeno en vaquillonas Brangus y respuesta a la suplementación con cobre. Revista Veterinaria, v. 12, n. 1 y 2, p. 28-33, 2016. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. GRAHAM, Thomas W. Trace element deficiencies in cattle. Veterinary clinics of North America: food animal practice, v. 7, n. 1, p. 153-215, 1991. GUEDES, Luciana Freitas et al. A importância do cobre, molibdênio e enxofre na alimentação de ovinos. Nucleus Animalium, v. 10, n. 2, p. 7-22, 2018. HURLEY, W. L.; DOANE, R. M. Recent developments in the roles of vitamins and minerals in reproduction. Journal of Dairy Science, v. 72, n. 3, p. 784-804, 1989. KUMAR, Sudhir et al. Importance of micro minerals in reproductive performance of livestock. Veterinary world, v. 4, n. 5, p. 230, 2011. MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. MILLS, C. F. Cobalt deficiency and cobalt requirements of ruminants. Recent advances in animal nutrition, p. 129-141, 1981. NICODEMO, M. L. F.; SERENO, J. R. B.; AMARAL, T. B. Minerais na eficiência reprodutiva de bovinos. Embrapa Pecuária Sudeste-Documentos (INFOTECA-E), São Carlos, 2008. PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. QUIROZ-ROCHA, Gerardo F.; BOUDA, Jan. Fisiopatología de las deficiencias de cobre en rumiantes y su diagnóstico. Vet. Méx, v. 32, n. 4, p. 289, 2001. SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. YASOTHAI, R. Importance of minerals on reproduction in dairy cattle. International Journal of Science, Environment and Technology, v. 3, n. 6, p. 2051-2057, 2014. Emanuel Isaque Cordeiro da Silva Belo Jardim, 29 de março de 2020. (shrink)

Essa pesquisa elege como material específico de análise uma sequência de cursos oferecidos pelo “YouTube Academy” para a criação, gerenciamento e divulgação de uma empresa associada à plataforma de vídeos do YouTube. O objetivo é investigar os modos de imbricação e/ou separação entre o sujeito e a empresa. Para construir os procedimentos analíticos, delimitamos as seguintes perguntas: Como as formas imaginárias do sujeito (o “eu”, a identidade e a individualidade) estão relacionadas com a criação e o funcionamento de uma empresa (...) no YouTube? Como o trabalho e as relações de trabalho são significados nessa discursividade? A pesquisa é filiada à Análise de Discurso Materialista, em diálogo com autores que analisam as relações de trabalho contemporâneas. O olhar discursivo chega a três regularidades: 1) homogeneização das diferentes condições de produção no trabalho dos youtubers; 2) o paralelismo discursivo entre sujeito, canal e empresa (negócio); 3) uma retórica do equilíbrio entre “vida profissional” e “vida pessoal”. O material se sustenta no funcionamento de uma busca pela saturação dos sentidos com soluções e cursos para cada uma das etapas da (re)produção desse trabalho, para a suposta totalidade do processo. The specific analysis material for this essay was chosen from a sequence of courses, offered by the “YouTube Academy”, with the aim of creating, managing and announcing a company associated with the YouTube video platform. Its goal is to examine the ways of imbrication and/or separation between the subject and the company. In order to build the analytical procedures, we delineated the following questions: How are the imaginary for ms of the subject (the “self” as identity and individuality) related to the creation and operation of a company on YouTube? How are work and work relations meant in this discursivity? The research is affiliated with Materialist Discourse Analysis, in dialogue with authors who analyze contemporary work relations. The discursive look reaches three regularities: 1) homogenization of the different production conditions in the work of “youtubers”; 2) the discursive parallelism between subject, channel and company (busi-ness); 3) a rhetoric of the balance between “professional life” and “personal life”. The material is based on the operation of a search for the saturation of the senses with solutions and courses for each of the stages of the (re)production of this work, for the supposed totality of the process. (shrink)

As ciências médicas, biomédicas, humanas e sociais têm avançado de forma frenética nos últimos anos. Com isso, se faz cada vez mais necessário o debate ético que visa contemplar o respeito à dignidade humana, animal e ao meio ambiente. A bioética se dedica a esse debate e se propõe a estendê-lo a setores não acadêmicos, como sociedades de proteção dos animais, dos direitos humanos e até grupos religiosos. Essa diversidade de opiniões não só é interessante, mas necessária, uma vez que (...) os valores praticados em uma sociedade provêm de uma construção social cujos blocos fundamentais têm origem na família e nos diversos grupos sociais nos quais os indivíduos estão inseridos desde o seu nascimento. A proposta deste livro é fomentar esse debate, fornecendo conceitos e visões sobre temas selecionados da pesquisa e da prática médica, biotecnológica e de áreas correlatas. Em um contexto mundial de intolerância política, social, étnica e de gênero, oportunidades de debate também possuem um papel social de auxiliar no desenvolvimento consciente da cidadania e do respeito ao próximo. Sobretudo, o debate nos faz enxergar o outro como parelho, ainda que cada um possua as suas especificidades, opiniões e histórias de vida. (shrink)

Autogestão, autoempreendedorismo, infotrabalho, trabalho intermitente, criptomoeda, uberização, proletariado de serviços e servidão digital delineiam uma série de designações indicativas das mudanças das condições de (re)produção do Capital nas suas formas contemporâneas. Grandes corporações como Google, Facebook e Amazon participam desse processo tanto no eixo da infraestrutura econômica, quanto na produção discursiva que sustenta ideologicamente as relações de trabalho determinadas pelo Aparelho Digital. Essa pesquisa elege como material específico de análise uma sequência de cursos oferecidos pelo “YouTube Academy” para a criação, (...) gerenciamento e divulgação de uma empresa associada à plataforma de vídeos do YouTube. O objetivo é investigar os modos de imbricação e/ou separação entre o sujeito e a empresa. Para construir os procedimentos analíticos, delimitamos as seguintes perguntas: Como as formas imaginárias do sujeito (o “eu”, a identidade e a individualidade) estão relacionadas com a criação e o funcionamento de uma empresa no YouTube? Como o trabalho e as relações de trabalho são significados nessa discursividade? O olhar discursivo é ainda guiado por compreensões de pesquisas anteriores: o modo como o “eu” é discursivizado em produto, o funcionamento da “empresa de si” como modelo de identificação e a empresarialidade. As referências passam por Michel Pêcheux, Eni Orlandi, Suzy Lagazzi, Luciana Nogueira, Guilherme Adorno, Joel Bombardelli, Pierre Dardot, Christian Laval e Ricardo Antunes. O conceito de político, compreendido discursivamente como conflito e disputa pelos sentidos - e seus efeitos de deslocamento, assim como o apagamento do político do lugar que lhe seria próprio - e o conceito de exterioridade discursiva são mais enfaticamente mobilizados na pesquisa, além das discussões em torno do discurso neoliberal e da psicologização do sujeito pelos efeitos discursivos de liberdade e autonomia. Um trabalho de análise da constituição da discursividade que tem o “sentido (já) lá” como resultado do efeito de exterioridade. Esperamos mostrar, assim, como, nas condições de produção sócio-históricas de um “Imperialismo Digital”, uma mudança da “economia política do poder-dizer” afeta os modos de circulação não só dos discursos, mas do próprio Capital. (shrink)

This study analyses behavioral psychological facilitators and barriers to using different carsharing business models. It identifies the most preferable carsharing business models for different trip purposes as well as the main motivators for using it. Users of carsharing services (N=1,121) in German cities completed a questionnaire distributed by five operators representing three different business models: freefloating (FF), round-trip station-based (RTSB), and peer-to-peer (P2P). All analyses are performed from a Bayesian perspective and further discussion of the statistical analyses is included. The (...) main results indicate that there are different preferences for carsharing business models depending on the trip purpose, with a trade-off between free-floating and round-trip station-based business models. The peer-to-peer business model stood out for short holiday trips. Age, educational level, and income affected the probability of selecting different carsharing operators. Users of FF and RTSB differ regarding driving habits and trust in the services. (shrink)

Protopolybia sedula is a social swarming wasp, widely spread throughout many countries in the Americas, including most of Brazil. Despite its distribution, studies of its behavioral ecology are scarce. This study aimed to describe its foraging activity and relation to climatic variables in the city of Juiz de Fora in southeastern Brazil. Three colonies were under observation between 07:00 and 18:00 during April 2012, January 2013, and March 2013. Every 30 minutes, the number of foragers leaving and returning to the (...) colony was registered along with air temperature and relative humidity. Activity began around 07:30¸ increased between 10:30 and 14:30, and ended around 18:30. A mean of 52.7 exits and 54 returns were measured every 30 minutes. The daily mean values were 1,107 ± 510.6 exits and 1,135 ± 854.8 returns. Only one colony showed a significant correlation between forager exits and temperature (rs = 0.8055; P < 0.0001) and between exits and relative humidity (rs = -0.7441; P = 0.0001). This paper shows that climatic variables are likely to have little control on the foraging rhythm of P. sedula when compared to other species, suggesting the interaction of other external and internal factors as stimuli of species foraging behavior. (shrink)

According to Heidegger's Being and Time, social relations are constitutive of the core features of human agency. On this view, which I call a ‘strong conception’ of sociality, the core features of human agency cannot obtain in an individual subject independently of social relations to others. I explain the strong conception of sociality captured by Heidegger's underdeveloped notion of ‘being-with’ by reconstructing Heidegger's critique of the ‘weak conception’ of sociality characteristic of Kant's theory of agency. According to a weak conception, (...) sociality is a mere aggregation of individual subjects and the core features of human agency are built into each individual mind. The weak conception of sociality remains today widely taken for granted. I show that Christine Korsgaard, one of the most creative contemporary appropriators of Kant, operates with a weak conception of sociality and that this produces a problematic explanatory deficiency in her view: she is unable to explain the peculiar motivational efficacy of shared social norms. Heidegger's view is tailor made to explain this phenomenon. I end by sketching how Heidegger provides a social explanation of a major systematic concern animating Korsgaard, the concern with the importance of individual autonomy and answerability in human life. (shrink)

Does the recent success of Podemos and Syriza herald a new era of inclusive, egalitarian left populism? Because leaders of both parties are former students of Ernesto Laclau and cite his account of populism as guiding their political practice, this essay considers whether his theory supports hope for a new kind of populism. For Laclau, the essence of populism is an “empty signifier” that provides a means by which anyone can identify with the people as a whole. However, the concept (...) of the empty signifier is not as neutral as he assumes. As I show by analyzing the role of race in his theory, some subjects are constituted in a way that prevents their unmediated identification with the people. Consequently, Laclau’s view should be read as symptomatic of the problems with populist logic if its adherents are to avoid reproducing its exclusions and practice a more inclusive politics. (shrink)

This chapter first surveys general issues in the epistemic internalism / externalism debate: what is the distinction, what motivates it, and what arguments can be given on both sides. -/- The second part of the chapter will examine the internalism / externalism debate as regards to the specific case of the epistemology of memory belief.

(Added April 2023: This draft is superseded by Briggs, R.A., & George, B.R. (2023). 'What Even Is Gender?'. Routledge. DOI 10.4324/9781003053330, and in particular by the first three chapters thereof. While this much earlier draft remains available for archival purposes, you are encouraged to read and cite the 2023 book and to use its terminology.) -/- This paper presents a new taxonomy of sex/gender concepts based on the idea of starting with a few basic components of the sex/gender system, and (...) exhausting the possible types of simple associations and identities based on these. The resulting system is significantly more fine-grained than most competitors, and helps to clarify a number of points of confusion and conceptual tension in academic and activist conversations about feminism, transgender politics, and the social analysis of gender. (shrink)

A presente dissertação se propõe analisar, a partir do pensamento aristotélico, a noção de causalidade acidental no tocante a sua fusikh; ejpisthvmh. Aristóteles, buscando encontrar as causas que explicam o vir-a-ser dos seres por natureza, se deparou com os acidentes e, não podendo deixar nenhum evento sem causa, postulou a existência de causas acidentais. Apesar de o acidente não ser objeto de ciência, a possibilidade de seu vir a ser salvaguarda o mundo da fuvsi" de um determinismo causal absoluto: eis (...) o papel e a importância de uma causalidade acidental no mundo físico aristotélico. (shrink)

These days the two most popular approaches to belief ascription are Millianism and Contextualism. The former approach is inconsistent with the existence of ordinary Frege cases, such as Lois believing that Superman flies while failing to believe that Clark Kent flies. The Millian holds that the only truth-conditionally relevant aspect of a proper name is its referent or extension. Contextualism, as I will define it for the purposes of this essay, includes all theories according to which ascriptions of the form (...) ‘S believes that a is F’ and ‘S believes that b is F’, where ‘a’ and ‘b’ are coreferential proper names, may, depending on the context, differ in truth-value even though in those very contexts each ascription relates the same believer to the very same proposition. What the two theories have in common is the claim that names are Millian. What separates the two theories is what they say about belief contexts. In this essay I prove that Millianism is true, Contextualism is true, or our intuitions regarding belief ascriptions are hopelessly inaccurate. As a consequence, my argument is a proof that either names and many general terms are Millian or our intuitions regarding belief ascriptions are hopelessly inaccurate. (shrink)

This paper investigates a well-known case of simultaneous discovery in twentieth-century chemistry, the origins of the concept of hybridisation, in the light of Kuhn's insights. There has been no ambiguity as to who discovered this concept, when it was "rst in print, and how important it was. The full-#edged form of the concept was published in 1931 independently by two American scientists John C. Slater (1900}1976) and Linus Pauling (1901}1994), although both of them had made their ideas public earlier: Slater (...) at the American Physical Society meetings in 1930, and Pauling in the Proceedings of the National Academy of Sciences in 1928. Slater and Pauling both argued for the necessity of using an s orbital as well as three p orbitals in the carbon atom in order to explain carbon's four valences and the tetrahedral structure of methane. The metaphor &hybridisation' for denoting this mix of s and p orbitals was "rst used by Robert S. Mulliken and J. H. Van Vleck before gaining currency with the scienti"c community around 1935.2 The concept of hybridisation was indeed indispensable for extending the quantum-mechanical interpretation of the chemical bond as an electron pairing from diatomic molecules to polyatomic ones. To be sure, the emergence of hybridisation attests to scientists' growing interest in exploring the borderland between physics and chemistry, a trend that led to the creation of physical chemistry in the late nineteenth century and of chemical physics and quantum chemistry in the 1920s and 30s. Slater and Pauling themselves experienced and on many occasions talked about the fruitfulness of interdisciplinary research; and historians have legitimately illuminated their works by examining them in this broad context.3 Yet the careful analysis of their research notes and published papers reveals that Slater and Pauling were working in quite disparate disciplinary traditions, with di!erent approaches, for di!erent audiences, and towards di!erent goals. The aim of this paper is to explore their di!erent routes to a common destination*hybridisation*and thereby to explicate tensions existing between physics and chemistry amidst the institutional and conceptual overlapping of the two disciplines. (shrink)

Some objections to the idea that disputed territories should be auctioned.

I defend the following version of the ought-implies-can principle: (OIC) by virtue of conceptual necessity, an agent at a given time has an (objective, pro tanto) obligation to do only what the agent at that time has the ability and opportunity to do. In short, obligations correspond to ability plus opportunity. My argument has three premises: (1) obligations correspond to reasons for action; (2) reasons for action correspond to potential actions; (3) potential actions correspond to ability plus opportunity. In the (...) bulk of the paper I address six objections to OIC: three objections based on putative counterexamples, and three objections based on arguments to the effect that OIC conflicts with the is/ought thesis, the possibility of hard determinism, and the denial of the Principle of Alternate Possibilities. (shrink)

Universal Energetic Field Theory -/- Additional Argumentation No1: Newton's Third Law relation with the Universal Energetic Field -/- The atom nucleus Quarks energy, and their three generations energy or energy gain, are too submit to the (Albert Einstein) “Law Of The Conservation Of Energy”. Thus, throughout the Quarks 3 generations energetic states and generations transformations, the Newton's Third Law impose the addition of the Universal Energetic Field theory. Martin B.J. Thibault December 2020 .

In his Edifying Discourses, Soren Kierkegaard published a sermon entitled ‘The Unchangeableness of God’ in which he reiterated the dogma which dominated Catholic, Protestant and even Jewish expressions of classical supernaturalist theology from the first century A.D. until the advent of process theology in the twentieth century. The dogma that as a perfect being, God must be totally unchanging in every conceivable respect was expressed by Kierkegaard in such ways as: He changes all, Himself unchanged. When everything seems stable and (...) in the overturn of all things, He remains equally unchanged; no change touches Him, not even the shadow of a change; in unaltered clearness He, the father of lights, remained eternally unchanged. 1. (shrink)

The New Evil Demon problem has been hotly debated since the case was introduced in the early 1980’s (e.g. Lehrer and Cohen 1983; Cohen 1984), and there seems to be recent increased interest in the topic. In a forthcoming collection of papers on the New Evil Demon problem (Dutant and Dorsch, forthcoming), at least two of the papers, both by prominent epistemologists, attempt to resist the problem by appealing to the distinction between justification and excuses. My primary aim here is (...) to critically evaluate this new excuse maneuver as a response to the New Evil Demon problem. -/- Their response attempts to give us reason to reject the idea that victims of the New Evil Demon have justification for believing as they do. I shall argue that this approach is ultimately unsuccessful, however much of value can be learned from these attempts. In particular, progress in the debate can be made by following those who advance the excuse maneuver and make explicit the connection between epistemic justification and epistemic norms. By doing so, the questions being debated are clarified, as is the methodology being used to attempt to answer them. (shrink)

This paper attempts to open the debate on the idea of local and territorial development of microregional nodes in the Province of Buenos Aires. Under this approach, a model that proposes the creation of Municipal Development Forum, with the participation of local actors, generate local development program is proposed. The proposal is formulated for territories over 5,000 and below 30,000 inhabitants. This criterion is based on the applicability of the proposed model to municipalities with potential for territorial development, large and (...) balanced internal consumption, but where progress is hindered by the proximity of one or two political jurisdictions of a larger productive scale that have became regional administrative centers. The development program will consider a diagnosis of the productive profile of the territory and its relationship with the characteristics and origin of goods or services consumed at the municipality. This territorial development model aims to move towards self-sufficiency on goods and services, to create new jobs and to promote effective and efficient use of local resources. In short, we propose to tackle territorial development from an innovative perspective, focusing on the creation of Municipal Development Fora that foster the improvement and growth of the productive system, the creation of jobs, local identity and the consumption of goods and services locally produced. (shrink)

The current and the next issues of “Spazio Filosofico”, both devoted to Festival (Festival I and II respectively), are dedicated to Ugo Perone on the occasion of his 70th birthday. Perone’s friends and colleagues have chosen to celebrate his birthday in a philosophical way, namely, with a reflection on the concept of festival/holiday [festa] and its meaning for us today. Thrifty spirits might object that a journal issue is like a gift – one is enough. Are these not times of (...) economic crisis? There is no real festival, however, without a Zugabe: without an addition, an encore, or a supplement. Hence, two issues, both devoted to a single concept. The choice of the theme has not been accidental – the concept of “festival/holiday” plays in fact an important role in Perone’s thought. In an essay that is often quoted in various contributions to the two issues, Perone understands the pair of concepts “ultimate/penultimate,” which has been discussed by Dietrich Bonhoeffer, in terms of “holidays/everydayness.” For Bonhoeffer, God is present not where human abilities fail but rather “at the center of the village.” Likewise, for Perone, the square, which is the “symbol for the holiday time,” is the center of town. It is even, “at the same time, the center of town and its interruption.” . (shrink)

What is it to be a woman? What is it to be a man? We start by laying out desiderata for an analysis of 'woman' and 'man': descriptively, it should link these gender categories to sex biology without reducing them to sex biology, and politically, it should help us explain and combat traditional sexism while also allowing us to make sense of the activist view that gendering should be consensual. Using a Putnam-style 'Twin Earth' example, we argue that none of (...) the existing analyses in the feminist literature succeeds in meeting all of our desiderata. Finally, we propose a positive account that we believe can satisfy all the desiderata outlined. According to our theory, the genders 'woman' and 'man' are individuated not by their contemporary connections to sex biology, but by their historical continuity with classes that were originally closely connected to sex biology. (shrink)

What makes an intellectual virtue a virtue? A straightforward and influential answer to this question has been given by virtue-reliabilists: a trait is a virtue only insofar as it is truth-conducive. In this paper I shall contend that recent arguments advanced by Jack Kwong in defence of the reliabilist view are good as far as they go, in that they advance the debate by usefully clarifying ways in how best to understand the nature of open-mindedness. But I shall argue that (...) these considerations do not establish the desired conclusions that open-mindedness is truth-conducive. To establish these much stronger conclusions we would need an adequate reply to what I shall call Montmarquet’s objection. I argue that Linda Zagzebski’s reply to Montmarquet’s objection, to which Kwong defers, is inadequate. I conclude that it is contingent if open-mindedness is truth-conducive, and if a necessary tie to truth is what makes an intellectual virtue a virtue, then the status of open-mindedness as an intellectual virtue is jeopardised. We either need an adequate reliabilist response to Montmarquet’s objection, or else seek alternative accounts of what it is that makes a virtue a virtue. I conclude by briefly outlining some alternatives. (shrink)

In common with traditional forms of epistemic internalism, epistemological disjunctivism attempts to incorporate an awareness condition on justification. Unlike traditional forms of internalism, however, epistemological disjunctivism rejects the so-called New Evil Genius thesis. In so far as epistemological disjunctivism rejects the New Evil Genius thesis, it is revisionary. -/- After explaining what epistemological disjunctivism is, and how it relates to traditional forms of epistemic internalism / externalism, I shall argue that the epistemological disjunctivist’s account of the intuitions underlying the New (...) Evil Genius thought experiment is at best incomplete. As presented, therefore, epistemological disjunctivism is unable to accommodate the core guiding intuitions of epistemic internalism. Given the stated aim of not being revisionary on this score, the view is at a dialectical disadvantage over the traditional forms of epistemic internalism the position is meant to replace. Unfortunately, therefore, at present, the impasse between internalism and externalism remains. (shrink)

In this paper, I argue that self-awareness is intertwined with one's awareness of possibilities for action. I show this by critically examining Dan Zahavi's multidimensional account of the self. I argue that the distinction Zahavi makes among 'pre-reflective minimal', 'interpersonal', and 'normative' dimensions of selfhood needs to be refined in order to accommodate what I call 'pre-reflective self-understanding'. The latter is a normative dimension of selfhood manifest not in reflection and deliberation, but in the habits and style of a person’s (...) pre-reflective absorption in the world. After reviewing Zahavi's multidimensional account and revealing this gap in his explanatory taxonomy, I draw upon Heidegger, Merleau-Ponty, and Frankfurt in order to sketch an account of pre-reflective self-understanding. I end by raising an objection to Zahavi’s claim for the primitive and foundational status of pre-reflective self-awareness. To carve off self-awareness from the self’s practical immersion in a situation where things and possibilities already matter and draw one to act is to distort the phenomena. A more careful phenomenology of pre-reflective action shows that pre-reflective self-awareness and pre-reflective self-understanding are co-constitutive, both mutually for each other and jointly for everyday experience. (shrink)

In this article I argue that the value of epistemic justification cannot be adequately explained as being instrumental to truth. I intend to show that false belief, which is no means to truth, can nevertheless still be of epistemic value. This in turn will make a good prima facie case that justification is valuable for its own sake. If this is right, we will have also found reason to think that truth value monism is false: assuming that true belief does (...) have value, there is more of final epistemic value than mere true belief. (shrink)

Influential cases have been provided that seem to suggest that one can fail to have knowledge because of the social environment. If not a distinct kind of social defeater, is there a uniquely social phenomenon that defeats knowledge? My aim in this paper is to explore these questions. I shall argue that despite initial appearances to the contrary, we have no reason to accept a special class of social defeater, nor any essentially social defeat phenomenon. We can explain putative cases (...) of social defeat with our existing epistemological apparatus. (shrink)

The acquisition of a new skill usually proceeds through five stages, from novice to expert, with a sixth stage of mastery available for highly motivated performers. In this chapter, we re-state the six stages of the Dreyfus Skill Model, paying new attention to the transitions and interrelations between them. While discussing the fifth stage, expertise, we unpack the claim that, “when things are proceeding normally, experts don’t solve problems and don’t make decisions; they do what normally works” (Dreyfus & Dreyfus, (...) 1988, pp. 30 – 31). This leads us to offer an account of the “perspectival deliberation” that arises for experts and masters and that is distinct from the calculative deliberation characteristic of the lower stages of skillfulness. (shrink)

In general, epistemic internalists hold that an individual’s justification for a belief is exhausted by her reflectively accessible reasons for thinking that the contents of her beliefs are true. Applying this to the epistemology of testimony, a hearer’s justification for beliefs acquired through testimony is exhausted by her reflectively accessible reasons to think that the contents of the speaker’s testimony is true. A consequence of internalism is that subjects that are alike with respect to their reflectively accessible reasons are alike (...) with respect to what they have justification to believe. Testimony should be thought no different: hearers that are alike with respect to reflectively accessible reasons to think that a speaker’s testimony is true are alike with respect to their justification for beliefs based upon that testimony. But it has been recently argued that this view faces powerful counterexamples. So the central question is this: assuming that a hearer can acquire justification to believe a proposition through the testimony of a speaker, can epistemic internalism provide the resources to explain how such justification is possible? My aim in this paper is to address these counterexamples, and in so doing, defend epistemic internalist accounts of testimony. (shrink)

Imperatives cannot be true, but they can be obeyed or binding: `Surrender!' is obeyed if you surrender and is binding if you have a reason to surrender. A pure declarative argument — whose premisses and conclusion are declaratives — is valid exactly if, necessarily, its conclusion is true if the conjunction of its premisses is true; similarly, I suggest, a pure imperative argument — whose premisses and conclusion are imperatives — is obedience-valid (alternatively: bindingness-valid) exactly if, necessarily, its conclusion is (...) obeyed (alternatively: binding) if the conjunction of its premisses is. I argue that there are two kinds of bindingness, and that a vacillation between two corresponding variants of bindingness-validity largely explains conflicting intuitions concerning the validity of some pure imperative arguments. I prove that for each of those two variants of bindingness-validity there is an equivalent variant of obedience-validity. Finally, I address alternative accounts of pure imperative inference. (shrink)

This article attempts to open the debate on a territorial development perspective that fixes the interest in organized territories that are characterized by the existence of a community with a local identity, politically and administratively regulated. We conceive these territories as subjects of development promotion interventions. For this we propose a model for the creation of Municipal Development Forums, which with the participation of local actors, can generate a tailor-made Local Development Program. The development program will consider a diagnosis of (...) the productive profile of the territory and its relationship with the characteristics and origin of goods or services consumed at the municipality. Based on the diagnosis, the causes of the decoupling between the local production system and consumption needs can be detected. And with this, find a way to readjust local production systems to meet the demand for goods and services of the inhabitants, generating new companies and encouraging local consumption. (shrink)

In 2035 global egg demand will have risen 50% from 1985. Because we are not able to tell in the egg whether it will become a male or female chick, billons of one day-old male chicks will be killed. International research initiatives are underway in this area, and governments encourage the development of an alternative with the goal of eliminating the culling of day-old male chicks. The Netherlands holds an exceptional position in the European egg trade, but is also the (...) only country in the European Union where the downside of the egg sector, the practice of killing day-old male chicks, is a recurrent subject of societal debate. ‘Preventing the killing of young animals’ and ‘in ovo sex determination’ are the two alternative approaches available to solve this problem. It is clear that both approaches solve the problem of killing day-old male chicks, either by keeping them alive or by preventing them from living, but they also raise a lot of new animal welfare-related dilemmas. A thorough analysis was undertaken of these dilemmas and the results are presented in this article. The analysis resulted in an ethical framework based on the two main approaches in bioethics: a consequentialist approach and a deontological approach. This ethical framework was used to develop an online survey administered to ascertain Dutch public opinion about these alternative approaches. The results show that neither alternative will be fully accepted, or accepted by more than half of Dutch society. However, the survey does provide an insight into the motives that are important for people’s choice: food safety and a good treatment of animals. Irrespective of the approach chosen, these values should be safeguarded and communicated clearly. (shrink)

Often, there are conceptual differences between politicians, officials, academics and professionals on key concepts related to forms of administrative organization of the State and in relation to the categorization of the various subjects who directs their actions. Settle these differences contribute to the implementation of the modernization of the State. It is also necessary to distinguish conceptually between different degrees of protection can be invoked by natural and legal persons in the administration. To help settle these conceptual differences, we will (...) propose some key definitions related to governance, from a literature review and analysis of the actions of the state. (shrink)

Mitochondrial DNA (mtDNA) diseases are a group of neuromuscular diseases that often cause suffering and premature death. New mitochondrial replacement techniques (MRTs) may offer women with mtDNA diseases the opportunity to have healthy offspring to whom they are genetically related. MRTs will likely be ready to license for clinical use in the near future and a discussion of the ethics of the clinical introduction ofMRTs is needed. This paper begins by evaluating three concerns about the safety of MRTs for clinical (...) use on humans: (1) Is it ethical to use MRTs if safe alternatives exist? (2) Would persons with three genetic contributors be at risk of suffering? and (3) Can society trust that MRTs will be made available for humans only once adequate safety testing has taken place, and that MRTs will only be licensed for clinical use in a way that minimises risks? It is then argued that the ethics debate about MRTs should be reoriented towards recommendingways to reduce the possible risks of MRT use on humans. Two recommendations are made: (1) licensed clinical access to MRTs should only be granted to prospective parents if they intend to tell their children about their MRT conception by adulthood; and (2) sex selection should be used in conjunction with the clinical use ofMRTs, in order to reduce transgenerational health risks. (shrink)

This article seeks to establish the development of rural communities, with up to 500 inhabitants, with the creation of a Rural Tourism Development Forum and a Tourism Development Program with local identity. It is proposed to capitalize on cultural assets and local knowledge, to strengthen the profile and tourist circuits, local services and enterprises, agro-tourism and other related economic and social activities. The objective is to contribute to territorial tourism development from an innovative perspective, which, based on the efficient use (...) of local resources, generates employment and improves the quality of life of its inhabitants, capitalizing on the advantages of tourist activity. The methodology used consisted in analyzing the problems of local development, identifying the obstacles and conceiving tourism as a solution and sustenance that allowed the elaboration of the model. (shrink)

The current resurgence of interest in cognition and in the nature of cognitive processing has brought with it also a renewed interest in the early work of Husserl, which contains one of the most sustained attempts to come to grips with the problems of logic from a cognitive point of view. Logic, for Husserl, is a theory of science; but it is a theory which takes seriously the idea that scientific theories are constituted by the mental acts of cognitive subjects. (...) The present essay begins with an exposition of Husserl's act-based conception of what a science is, and goes on to consider his account of the role of linguistic meanings, of the ontology of scientific objects, and of evidence and truth. The essay concentrates almost exclusively on the Logical Investigations of 1900/01. This is not only because this work, which is surely Husserl's single most important masterpiece, has been overshadowed first of all by his Ideas I and then later by the Crisis. It is also because the Investigations contain, in a peculiarly clear and pregnant form, a whole panoply of ideas on logic and cognitive theory which either simply disappeared in Husserl's own later writings or became obfuscated by an admixture of that great mystery which is 'transcendental phenomenology'. (shrink)

In the wake of the advent of genome editing technology CRISPR-Cas9 (clustered regularly interspaced palindromic repeat (CRISPR)-associated protein 9), there has been a global debate around the implications of manipulating the human genome. While CRISPR-based germline gene editing is new, the debate about the ethics of gene editing is not – for several decades now, scholars have debated the ethics of making heritable changes to the human genome. The arguments that have been raised both for and against the use of (...) genetic technologies in human reproduction reiterate much of the arguments made in the pre-CRISPR debate. As such, it is instructive for South Africa to reflect on these arguments now, in considering our position on the regulation of the use of this novel biotechnology. There are two dominant schools of thought in this area, bioliberalism and bioconservatism. Bioconservatives raise concerns about the risks of genetic manipulation, and argue that it ought to be limited or prohibited to avert these risks to human health and human nature. Bioliberal scholars are more open to the prospect of genetic manipulation, because of its potential utility. In this article, I conclude that in liberal democracies such as our own, bioliberal arguments ought to be seriously considered when formulating policy on human genome editing because of the extent to which they resonate with our Constitutional values and human rights. I further suggest that there is a need for an enquiry into the relevance of African perspectives on the ethical questions that arise concerning germline genome editing. (shrink)

The aim of this paper was to present ongoing research on the social representations relating to ritalin in Brazil between 1998 and 2008. Over this period, there was a considerable increase in ritalin usage and expansion of its use to purposes other than therapeutic use. Ritalin has been used not only for treating attention disorders, but also to enhance cognitive functions in healthy individuals. The research has developed through two fields of investigation with different methodologies. In the first field, Brazilian (...) scientific and popular publications have been investigated, with analysis on the arguments justifying ritalin usage and how scientific results are disseminated to the lay public in large-circulation newspapers. In the second field, focus groups have been used to explore the social representations that university students, students' parents and healthcare professionals have in relation to the use of ritalin for enhancing cognitive performance. -/- . (shrink)

Proponents of the problem of animal suffering claim that the millions of years of apparent nonhuman animal pain and suffering provides evidence against the existence of God. Neo-Cartesianism attempts to avoid this problem mainly by denying the existence of phenomenal consciousness in nonhuman animals. However, neo-Cartesian options regarding animal minds have failed to compel many. In this essay, I explore an answer to the problem of animal suffering inspired by the medieval theologian Thomas Aquinas. Instead of focusing on phenomenal consciousness, (...) the neo-Thomistic view of animal minds focuses on self-awareness. After proposing and providing evidence for this view, I conclude that nonhuman animal suffering is not morally significant. (shrink)

Early Heidegger argues that a “homogenous space of nature” can be revealed by stripping away the intelligibility of Dasein's everyday world, a process he calls “deworlding.” Given this, some interpreters have suggested that Heidegger, despite not having worked out the details himself, is also committed to a notion of deworlded time. Such a “natural time” would amount to an endogenous sequentiality in which events are ordered independently of Dasein and the stand it takes on its being. I show that Heidegger (...) was indeed committed to such a temporal realism even though his treatment of these issues is somewhat scattered and pulled in different directions. In the course of my reconstruction, I renew an interpretation of Heidegger that stresses Dasein's thrownness into nature and I answer William Blattner's powerful interpretation of Heidegger as a failed temporal idealist who was unable to derive the sequentiality of ordinary time from Dasein's non-sequential originary temporality. Heidegger did not attempt to derive sequentiality; instead, he understood it as a built-in feature of the natural universe by which Dasein's activities are constrained. World-time turns out to be a co-production of Dasein's non-sequential originary temporality and the endogenous sequentiality of events in nature. (shrink)

This paper provides an interpretation of the existential conception of selfhood that follows from Merleau-Ponty’s account of perception. On this view, people relate to themselves not by “looking within” in acts of introspection but, first, by “looking without” at the field of solicitations in which they are immersed and, eventually, in Merleau-Ponty’s words, by “making explicit” the “melodic unity” or “immanent sense” of their behavior. To make sense of this, I draw out a distinction latent in Merleau-Ponty’s view between a (...) pre-reflective sense of self and a reflective self-interpretation. The former is a suite of abilities and dispositions in light of which a person is aware of and drawn to act in a situation. This sense of self undergoes transitions over time, is constitutively susceptible to moments of disorientation, and tends toward but never achieves full coherence. Reflective self-interpretation is an activity whereby someone—provisionally and defeasibly—clarifies, articulates, and gets a better “grip” on how they are prereflectively drawn to act. I ground this interpretation in a detailed reading of Merleau-Ponty’s treatment of romantic love and I corroborate it by examining his account of the emergence of class-consciousness in the self-interpretation of a worker. (shrink)

Both Martin Heidegger and Harry Frankfurt have argued that the fundamental feature of human identity is care. Both contend that caring is bound up with the fact that we are finite beings related to our own impending death, and both argue that caring has a distinctive, circular and non-instantaneous, temporal structure. In this paper, I explore the way Heidegger and Frankfurt each understand the relations among care, death, and time, and I argue for the superiority of Heideggerian version of this (...) nest of claims. Frankfurt claims that we should conceive of the most basic commitments which practically orient a person in the world and define his identity (“volitional necessities”) as naturalistic facts, foundational for and located completely without the normative space of reasons. In support of this he appeals to the supposedly foundational role played in human life by the instinct for self-preservation, what Frankfurt calls the “love of living.” The claim is that in questions of practical identity there is a definite priority of the factual over the normative. Frankfurt’s naturalistic model of volitional necessity is motivated by a misunderstanding of the temporal structure of care, a misunderstanding that helps lead him to an implausible conception of the basic structures of human identity. Heidegger advances an anti-naturalistic conception of caring, one bound up with his way of understanding how human beings relate to their own future. I argue that the existential, temporal, and normative significance that Frankfurt attributes to the naturalized “love of living” is better captured by the Heideggerian claim that human identity is defined by being “for-the-sake-of” certain projects and commitments, a way of being lived out in the way Heidegger calls “being-towards-death.”. (shrink)

We presuppose a position of scientific realism to the effect (i) that the world exists and (ii) that through the working out of ever more sophisticated theories our scientific picture of reality will approximate ever more closely to the world as it really is. Against this background consider, now, the following question: 1. Do the empirical theories with the help of which we seek to approximate a good or true picture of reality rest on any non-empirical presuppositions? One can answer (...) this question with either a 'yes' or a 'no'. 'No' is the preferred answer of most contemporary methodologists -- Murray Rothbard is one distinguished counterexample to this trend -- who maintain that empirical theories are completely free of non-empirical ('a priori') admixtures and who see science as a matter of the gathering of pure 'data' obtained through simple observation. From such data scientific propositions are then supposed to be somehow capable of being established. (shrink)

Epistemic internalism, by stressing the indispensability of the subject’s perspective, strikes many as plausible at first blush. However, many people have tended to reject the position because certain kinds of beliefs have been thought to pose special problems for epistemic internalism. For example, internalists tend to hold that so long as a justifier is available to the subject either immediately or upon introspection, it can serve to justify beliefs. Many have thought it obvious that no such view can be correct, (...) as it has been alleged that internalism cannot account for the possibility of the justification of beliefs stored in memory. -/- My aim in this paper is to offer a response that explains how memory justification is possible in a way that is consistent with epistemic internalism and an awareness condition on justification. Specifically, I will explore the plausibility of various options open to internalists, including both foundationalist and non-foundationalist approaches to the structure of justification. I intend to show that despite other difficult challenges that epistemic internalism might face, memory belief poses no special problems that the resources of internalism cannot adequately address. (shrink)

In this introduction, we cover some ways in which the topic of noise is discussed today, and then point to some important open questions about noise and its experience. We then provide a synopsis of the papers collected in the volume.

The APA has recently taken steps to address concerns related to teaching and supporting philosophers and students who come from less privileged backgrounds. I want to add to this project by fleshing out some concrete ways that philosophy professors contribute to the challenges faced by first-generation and financially disadvantaged philosophers and students. I hope that in making these behaviors explicit, it may be easier for faculty to acknowledge and overcome them.