The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

This article identifies an argument in Hobbes’s writings often overlooked but relevant to current philosophical debates. Political philosophers tend to categorize his thought as representing consent or rescue theories of political authority. Though these interpretations have textual support and are understandable, they leave out one of his most compelling arguments – what we call the lesser evil argument for political authority, expressed most explicitly in Chapter 20 of Leviathan. Hobbes frankly admits the state’s evils but appeals to the significant disparity (...) between those evils and the greater evils outside the state as a basis for political authority. More than a passing observation, aspects of the lesser evil argument appear in each of his three major political works. In addition to outlining this argument, the article examines its significance both for Hobbes scholarship and recent philosophical debates on political authority. (shrink)

Hasan's (1984) Model of Cohesive Harmony Analysis (CHA) represents one of the first attempts within the SFL framework to devise a relatively objective index for measuring a text's coherence. As a development of the classic "cohesion analysis"(Halliday & Hasan 1976), it probes into the coherence of a text by considering discourse structure as being based in both the syntagmatic and the paradigmatic semantic relations between components of clauses. More than thirty years later, it is still widely used as an effective (...) tool for language teaching and linguistic pathology. This paper will trace its origin, introduce its basic concepts and analytical procedure, describe its applications and consider its possible future development. (shrink)

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

This article investigates a central yet perplexing term yiming in the ‘Qiwulun’ chapter of the Zhuangzi. Yiming describes a crucial way to detach from epistemic distinctions and debates. This term is often explained as ‘using ming’ or contradictorily as ‘stopping ming’. Yet neither of the two explanations can provide a full understanding of how yiming is adopted. I take three steps to explain yiming. First, taking an etymological approach, I argue that ming can be formulated as ‘X shining on Y’. (...) Second, I use the formula of ‘X shining on Y’ to account for yiming and argue that this term refers specifically to ‘using tian to shine on everything’. Third, I unpack a cluster of tian-associated metaphors, which provides a deep understanding of yiming as an ideal way to mental tranquility. (shrink)

Regulative virtue epistemology argues that intellectual virtues can adjust and guide one’s epistemic actions as well as improve on the quality of the epistemic actions. For regulative virtue epistemologists, intellectual virtues can be cultivated to a higher degree; when the quality of intellectual virtue is better, the resulting quality of epistemic action is better. The intellectual virtues that regulative epistemologists talk about are character virtues (such as intellectual courage and open-mindedness) rather than faculty virtues (such as sight and hearing), since (...) they don’t think that faculty virtues could be cultivated. This article refers to Xunzi’s philosophy, explaining how a regulative faculty-based virtue epistemology is possible. If this explanation works, on the one hand, a new branch of contemporary virtue epistemology is shown, and, on the other hand, a clear theoretical framework of Xunzi’s epistemology is constructed. (shrink)

This paper examines the Confucian concept of tian, conventionally translated into English as “Heaven.‘ The secondary literature on tian has primarily focused on the question of what tian is: e.g., whether tian is an anthropomorphic deity or a naturalistic force, or whether tian is transcendent or immanent. Instead, this paper locates tian with respect to the ethical life of human beings, and argues that the two conflicting concepts of “moral economy‘ and “contingency‘ are main (...) characteristics of tian. This paper further investigates these characteristics in Kongzi’s and Mengzi’s ethical thought: how they conceptualized moral economy and contingency, and how their different conceptualizations shaped their respective ethical programs: Kongzi’s ethics of faith and Mengzi’s ethics of confidence. (shrink)

This paper proposes a reinterpretation of the Chinese worldview on equilibrium/nonequilibrium and yin-yang. Important terminologies and concepts that constitute Yijing have correlative aspects with irreversible thermodynamics and quantum reality- instability, nonlinearity, nonequilibrium and temporality. Ilya Prigogine is a Nobel laureate noted for his contribution to dissipative structures and their role in thermodynamic systems far from equilibrium, complexity and irreversibility. His expressions, as argued in this paper, resonate with the principles in Yijing. Thus, this paper attempts to re-state existing interpretations of (...) Yijing’s ideas with reference to science. Understanding Yijing’s terms and concepts must be contextualised to account for its pervasiveness of temporality and the change process. Otherwise, these cardinal concepts may be misconstrued as a hodgepodge of Eastern traditions with no relevance to modern science. This paper concentrates on the fundamental role of indeterminism in nonlinear systems on classical and quantum levels using Yijing’s conceptual framework. It concludes that the dominant ideas in Yijing and ancient Chinese philosophy resonate with the current scientific belief – the end of certainty. Instability, far-from-equilibrium, irreversibility, probability, bifurcation, and self-organisation are intrinsic properties of nature appearing at all levels, from particle, protein folding, and DNA double helix to cosmological scales. Information is the basis of all changes, and the agency of change is the human (‘ren’) with a consciousness existing in the probability space between heaven (‘tian’) and earth (‘di’). Finally, this paper outlines a modelling approach with the self-organising human in the centre between heaven and earth, representing living systems as discrete dynamical systems presented with binary choices (yin-yang). The interplay of yin and yang lines in a hexagram is thought to reflect the changing dynamics of a given situation, and the interpretation of the hexagram is based on the relationships between the yin and yang lines based on informational availability. In this way, the concepts of yin-yang and information causality are central to Yijing's understanding of change and are clarified in this paper. (shrink)

The Chinese rites controversy is typically characterized as a religious quarrel between different Catholic orders over whether it was permissible for Chinese converts to observe traditional rites and use the terms tian and shangdi to refer to the Christian God. As such, it is often argued that the conflict was shaped predominantly by the divergent theological attitudes between the rites-supporting Jesuits and their anti-rites opponents towards “accommodation.” By examining the Jesuit missionary Kilian Stumpf's Acta Pekinensia—a detailed chronicle of the (...) papal legate Charles-Thomas Maillard de Tournon's 1705–6 investigation into the controversy in Beijing—this article proposes that ostensibly religious disputes between Catholic orders consisted primarily of disagreements over ancient Chinese history. Stumpf's text shows that missionaries’ understandings of antiquity were constructed through their interpretations of ancient Chinese books and their interactions with the Kangxi Emperor. The article suggests that the historiographical characterization of the controversy as “religious” has its roots in the Vatican suppression of the rites, which served to erase the historical nature of the conflict exposed in the Acta Pekinensia. (shrink)

This paper aims to offer a critical review of the recent nonconceptualist reading of the Kantian notion of sensible intuition. I raise two main objections. First, nonconceptualist readers fail to distinguish connected but different anti-intellectualist claims in the contemporary philosophy of mind and language. Second, I will argue that nonconceptual readings fail because Kan- tian intuitions do not possess a representational content of their own that can be veridical or falsidical in a similar way to how the content of (...) propositional attitudes is true or false. In this paper, I will support my own reading that sensible intuition is better seen as what Evans and McDowell have called a de re sense, whose main characteristic is object dependence. In this sense, Kantian sensible intuitions can be seen as a sensible mode of donation of objects. In my reading, the Kantian opposition between intuitions and concepts is best seen as the opposition between the objectual de re perception of something and the propositional de dicto apperception that something is the case rather than the opposition between nonconceptual and conceptual contents. However, if Kantian sensible intuition is not a mental state with nonconceptual content, it is certainly in the general anti-intellectualist neighborhood. (shrink)

This article, translated into Chinese by Tian Kaifang, summarizes and critically reflects on the current state of the literature that has recently begun to put Chinese Confucianism into dialogue with characteristically African conceptions of what is good, what fundamentally exists, and how to obtain knowledge. As most of this literature has addressed value theory, this article focuses largely on it, too. It first illustrates how similar the foundational values are between the two cultural traditions; central to both traditional China (...) and Africa is an ethic prescribing the development of one’s humanness through virtues that honour harmonious relationships. The article then indicates how the two traditions nonetheless have different understandings of the nature of harmony, which have grounded divergent judgments of which practices are morally desirable. The final section of the article discusses ontology and epistemology, which are extremely under-developed in the comparative literature, and it suggests some avenues for future research on these topics. (shrink)

This paper aims to offer a critical review of the recent noncontextualist reading of the Kantian notion of sensible intuition. I raise two main objections. First, nonconceptualist readers fail to distinguish connected but different anti-intellectualist claims in the contemporary philosophy of mind and language. Second, I will argue that nonconceptual readings fail because Kan- tian intuitions do not possess a representational content of their own that can be veridical or falsidical in a similar way to how the content of (...) propositional attitudes is true or false. In this paper, I will support my own reading that sensible intuition is better seen as what Evans and McDowell have called a de re sense, whose main characteristic is object dependence. In this sense, Kantian sensible intuitions can be seen as a sensible mode of donation of objects. In my reading, the Kantian opposition between intuitions and concepts is best seen as the opposition between the objectual de re perception of something and the propositional de dicto apperception that something is the case rather than the opposition between nonconceptual and conceptual contents. However, if Kantian sensible intuition is not a mental state with nonconceptual content, it is certainly in the general anti-intellectualist neighborhood. (shrink)

This volum includes 37 papers of mathematics or applied mathematics written by the author alone or in collaboration with the following co-authors: Cătălin Barbu, Mihály Bencze, Octavian Cira, Marian Niţu, Ion Pătraşcu, Mircea E. Şelariu, Rajan Alex, Xingsen Li, Tudor Păroiu, Luige Vlădăreanu, Victor Vlădăreanu, Ştefan Vlăduţescu, Yingjie Tian, Mohd Anasri, Lucian Căpitanu, Valeri Kroumov, Kimihiro Okuyama, Gabriela Tonţ, A. A. Adewara, Manoj K. Chaudhary, Mukesh Kumar, Sachin Malik, Alka Mittal, Neetish Sharma, Rakesh K. Shukla, Ashish K. Singh, Jayant (...) Singh, Rajesh Singh, V.V. Singh, Hansraj Yadav, Amit Bhaghel, Dipti Chauhan, V. Christianto, Priti Singh, and Dmitri Rabounski. (shrink)

Friedrich Schleiermacher suggested that his project was to make Christianity compatible with reason and with the natural sciences. This article argues that Schleiermacher re- jected Christian doctrine und developed a religion which he called ‘Christian’ but which does not contain the Chris- tian doctrine and which is not rational. The article sketches Schleiermachers rejection of Christian doctrine, examines his claim that the natural sciences exclude miracles, criti- cises Schleiermachers non-cognitivism, and sketches the role of doctrine in Christianity.