Do trees of life have roots? What do these roots look like? In this contribution, I argue that research on the origins of life might offer glimpses on the topology of these very roots. More specifically, I argue (1) that the roots of the tree of life go well below the level of the commonly mentioned ‘ancestral organisms’ down into the level of much simpler, minimally living entities that might be referred to as ‘protoliving systems’, and (...) (2) that further below, a system of roots gradually dissolves into non-living matter along several functional dimensions. In between non-living and living matter, one finds physico-chemical systems that I propose to characterize by a ‘lifeness signature’. In turn, this ‘lifeness signature’ might also account for a diverse range of biochemical entities that are found to be ‘less-than-living’ yet ‘more-than-non-living’. (shrink)

Internodons are a formalization of Hennig's concept of species. We present an alternative construction of internodons imposing a tree structure on the genealogical network. We prove that the segments (trivial unary trees) from this tree structure are precisely the internodons. We obtain the following spin-offs. First, the generated tree turns out to be an organismal tree of life. Second, this organismal tree is homeomorphic to the phylogenetic Hennigian species tree of life, implying (...) the discovery of a multi-level tree of life: this phylogenetic tree can be obtained by zooming out from the organismal tree, or conversely, the organismal tree of life can be generated by expanding the phylogenetic nodes into unary trees. Finally, the definition of the organismal tree allows an efficient algorithmic transformation of a given genealogical network into its corresponding phylogenetic species tree of life. The latter will be presented in a separate paper. (shrink)

The Tree of Life has traditionally been understood to represent the history of species lineages. However, recently researchers have suggested that it might be better interpreted as representing the history of cellular lineages, sometimes called the Tree of Cells. This paper examines and evaluates reasons offered against this cellular interpretation of the Tree of Life. It argues that some such reasons are bad reasons, based either on a false attribution of essentialism, on a misunderstanding of (...) the problem of lineage identity, or on a limited view of scientific representation. I suggest that debate about the Tree of Cells and other successors to the traditional Tree of Life should be formulated in terms of the purposes these representations may serve. In pursuing this strategy, we see that the Tree of Cells cannot serve one purpose suggested for it: as an explanation for the hierarchical nature of taxonomy. We then explore whether, instead, the tree may play an important role in the dynamic modeling of evolution. As highly-integrated complex systems, cells may influence which lineage components can successfully transfer into them and how they change once integrated. Only if they do in fact have a substantial role to play in this process might the Tree of Cells have some claim to be the Tree of Life. (shrink)

According to Charles S. Peirce and to Mariano Artigas, science is the collective and cooperative activity of all those whose lives are animated by the desire to discover the truth. The particular sciences are branches of a common tree. The unity of science is not achieved by the reduction of the special sciences to more basic ones: the new name for the unity of the sciences is cross-disciplinarity. This is not a union of the sciences themselves, but rather the (...) unity and dialogue of scientists, the real inquirers into the truth. In the light of Peirce’s and Artigas’s teachings, we can see that philosophers are in just the right place to call for this unity of sciences. This call should not be seen as promoting a return to the old scientism, but seeks a deep dialogue between the particular sciences and philosophy in order to deal with the presuppositions of the scientific enterprise. The key to the cross-disciplinarity of knowledge is not revolution, but rather shared efforts in a unique mixture of continuity and fallibilism, of affection and reason, of the attempt to understand others’ disciplines as well as our own. (shrink)

How can humanist principles of respect, dignity, and care inform and improve design for non-human lifeforms? This paper uses ageing and dying urban trees to understand how architectural, urban, and landscape design respond to nonhuman concerns. It draws on research in plant sciences, environmental history, ethics, environmental management, and urban design to ask: how can more-than-human ethics improve multispecies cohabitation in urban forests? The paper hypothesises that concepts of dignity and respect can underline the capabilities of nonhuman lifeforms and lead (...) to improved designs for multispecies cohabitation. To investigate the implications of this ethical framework, we 1) indicate injustices of current management in relation to natural and cultural histories of trees; 2) outline a conceptual framework that includes large old trees as stakeholders in urban communities; and 3) use this framework in a thought experiment with urban trees in Melbourne, outlining comparative design outcomes. Our findings show that the expansion of dignity to include nonhuman life is possible and plausible. Such an extension can justify and encourage design innovation for multiple species and sites. The resulting design practices will lead to improvements by supporting communities of trees at all stages of their life-cycles, including old age, death, and rebirth. This approach requires substantial shifts in accepted thinking and practices including history, ethics, aesthetics, regulation, and education. Design can play a significant role in the necessary transitions by demonstrating tangible and positive outcomes. In this context, history emerges as an essential tool that can extend societal imagination by situating possible future places in the context of ancient and ongoing geological, evolutionary, ecological, and cultural processes. (shrink)

Organismal death is foundational to the evolution of life, and many biological concepts such as natural selection and life history strategy are so fashioned only because individuals are mortal. Organisms, irrespective of their organization, are composed of basic functional units—cells—and it is our understanding of cell death that lies at the heart of most general explanatory frameworks for organismal mortality. Cell death can be exogenous, arising from transmissible diseases, predation, or other misfortunes, but there are also endogenous forms (...) of death that are sometimes the result of adaptive evolution. These endogenous forms of death—often labeled programmed cell death, PCD—originated in the earliest cells and are maintained across the tree of life. Here, we consider two problematic issues related to PCD (and cell mortality generally). First, we trace the original discoveries of cell death from the nineteenth century and place current conceptions of PCD in their historical context. Revisions of our understanding of PCD demand a reassessment of its origin. Our second aim is thus to structure the proposed origin explanations of PCD into coherent arguments. In our analysis we argue for the evolutionary concept of PCD and the viral defense-immunity hypothesis for the origin of PCD. We suggest that this framework offers a plausible account of PCD early in the history of life, and also provides an epistemic basis for the future development of a general evolutionary account of mortality. (shrink)

I applaud recent improvements upon previous guidelines for the assessment of pain in non-human species and the application of their framework towards decapod crustaceans. Rather than constituting a mere intermediate solution between the scientific difficulty of settling questions of animal consciousness and the need for a framework for the purposes of animal welfare legislation, I will argue that the longer lists of criteria for animal sentience should make us realize that animal sentience is a multi-dimensional phenomenon that must be studied (...) with a plethora of methods in order to assess its diversity across the tree of life. (shrink)

Creationists who object to evolution in the science curriculum of public schools often cite Jonathan Well’s book Icons of Evolution in their support (Wells 2000). In the third chapter of his book Wells claims that neither paleontological nor molecular evidence supports the thesis that the history of life is an evolutionary process of descent from preexisting ancestors. We argue that Wells inappropriately relies upon ambiguities inherent in the term ‘Darwinian’ and the phrase ‘Darwin’s theory’. Furthermore, he does not accurately (...) distinguish between the overwhelming evidence that supports the thesis of common descent and controversies that pertain to causal mechanisms such as natural selection. We also argue that Wells’ attempts to undermine the evidence in support of common descent are flawed and his characterization of the relevant data is misleading. In particular, his assessment of the ‘Cambrian explosion’ does not do justice to the fossil record. Nor do his selective references to debate about molecular and paleontological phylogenies constitute a case against common descent. We conclude that the fossil and molecular evidence is more than sufficient to warrant science educators to present common descent as a well-established scientific fact. We also argue that diagrams depicting the ‘tree of life’ can be pedagogically useful as simplified representations of the history of life. (shrink)

Time has puzzled scientists. Some see it as just a tool and a unit of measurement, while others consider time to be a real thing and needs to be measured. There are also those who believe that time is an ancient thing that arose with the creation of the universe and the Earth, running parallel to life in them, and counting every movement, event, or speed in them. While some see it as an essential part and a major component (...) of the virtual relationship that includes life and place, there are also those who see time as a metaphysical thing that only appeared and developed in human consciousness and then mixed with the physics of life. Is duration measured by movement, or is movement measured by duration or time? Here began the dilemma of this research: How did time transform from a concept that reads and measures the flow of time forward, that is, the flow of time, according to Isaac Newton, into a physical measuring tool that calculates the movement, speed, and state of things? Then the concept turned into a tool that calculates the speed of light and tells the story of the origin and development of the universe. Scientists will not agree on a clear, direct, and frank interpretation of the concept of time, but people generally agree that time can be divided into past, present, and future. This division, according to this research, has gradually developed in human consciousness since the manifestations of knowledge appeared in the human mind and began to take its first steps. In the wondrous land where the sun rises repeatedly, the moon also rises, planets and stars appear, trees grow, rivers and seas overflow, storms and rain intensify, light appears and then darkness, and creatures wake up and sleep, mysteriously and repeatedly, until all these phenomena have become Appearances are measurable, with the development of human consciousness. In this brief research paper, we will discuss what is called “the present,” and the validity of its existence in the real time in which we live, and where its place is in human consciousness, and why scientists let it tamper with mathematical, physical, and social matter, and transformed it from a mere thing that does not exist, to a rest stop, which sometimes takes a long time., between the past and the future. (shrink)

“Selfish” gene theories have offered invaluable insight into eukaryotic genome evolution, but they can also be misleading. The “selfish mitochondrion” hypothesis, developed in the 90s explained uniparental organelle inheritance as a mechanism of conflict resolution, improving cooperation between genetically distinct compartments of the cell. But modern population genetic models provided a more general explanation for uniparental inheritance based on mutational variance redistribution, modulating the efficiency of both purifying and adaptive selection. Nevertheless, “selfish” conflict theories still dominate the literature. While these (...) hypotheses are rich in metaphor and highly intuitive, selective focus on only one type of mitochondrial mutation limits the generality of our understanding and hinders progress in mito-nuclear evolution theory. Recognizing that uniparental inheritance may have evolved – and is maintained across the eukaryotic tree of life – because of its influence on mutational variance and improved selection will only increase the generality of our evolutionary reasoning, retaining “selfish” conflict explanations as a special case of a much broader theory. (shrink)

By means of a probabilistic mathematical model, we bring into discussion the origin of life as a stochastic process. We consider only the chance of information emergence in the proteome and genome under the ideal thermodynamic and chemical conditions. For a more realistic model, we used, as a parameter, the information amount in N. equitans genome, the simplest known nowadays, as the equivalent to the first living cell that could have emerged in primitive Earth. We estimated the probability of (...) information emergence by chance as being smaller than 10-500’000. Considering the necessary ideal conditions for information emergence, the probability of the origin of life would be even smaller. (shrink)

hroughout medieval Christianity, religious works of art emerged to illustrate the teachings of the Bible for the largely illiterate population. What, then, is the significance of the psychoactive mushrooms hiding in plain sight in the artwork and icons of many European and Middle-Eastern churches? Does Christianity have a psychedelic history? -/- Providing stunning visual evidence from their anthropological journey throughout Europe and the Middle East, including visits to Roslyn Chapel and Chartres Cathedral, authors Julie and Jerry Brown document the role (...) of visionary plants in Christianity. They retrace the pioneering research of R. Gordon Wasson, the famous “sacred mushroom seeker,” on psychedelics in ancient Greece and India, and among the present-day reindeer herders of Siberia and the Mazatecs of Mexico. Challenging Wasson’s legacy, the authors reveal his secret relationship with the Vatican that led to Wasson’s refusal to pursue his hallucinogen theory into the hallowed halls of Christianity. -/- Examining the Bible and the Gnostic Gospels, the authors provide scriptural support to show that sacred mushrooms were the inspiration for Jesus’ revelation of the Kingdom of Heaven and that he was initiated into these mystical practices in Egypt during the Missing Years. They contend that the Trees of Knowledge and of Immortality in Eden were sacred mushrooms. -/- Uncovering the role played by visionary plants in the origins of Judeo-Christianity, the authors invite us to rethink what we know about the life of Jesus and to consider a controversial theory that challenges us to explore these sacred pathways to the divine. (shrink)

Research groups around the world are currently busy trying to invent new life in the laboratory, looking for extraterrestrial life, or making machines increasingly more life-like. In the case of astrobiology, any newly discovered life would likely be very old, but when discovered it would be new to us. In the case of synthetic organic life or life-like machines, humans will have invented life that did not exist before. Together, these endeavors amount to (...) what we call the emerging plurality of lives because we see a future where we are surrounded by, and interact with, life of many different origins, as well as entities that we have not traditionally seen as being alive. In the future these entities will likely possess properties that we so far have only associated with living beings, thereby transcending and perhaps blurring the borders between life and non-life. (shrink)

This is an edited transcript of a lecture given at the LSE in March 2023. The lecture introduces the “meaning of life” question via Tolstoy’s Confession, then considers the strengths and limitations of religious and secular answers to the question.

An outline of "philosophy of life" as a philosophical discipline is discussed. In today’s academic philosophy, we have “philosophy of biology,” which deals with creatures’ biological phenomena, “philosophy of death,” which concentrates on the concept of human death, and “philosophy of meaning of life,” which investigates difficult problems concerning the meaning of life and living. However, we do not have “philosophy of life,” which deals with philosophical problems concerning human life and the life of (...) non-human creatures. Hence, I proposed to establish “philosophy of life” as an academic discipline. We define philosophy of life as an academic research field that encompasses the following activities: 1) Cross-cultural, comparative, or historical research on philosophies of life, death, and nature. 2) Philosophical and ethical analysis of contemporary issues concerning human and non-human life in the age of modern technology. 3) philosophical analysis of the concepts surrounding life, death, and nature. (shrink)

Origin of life on earth transpired once and from then on, it emerges as an endless eternal process. Matter and energy are constants of the cosmos and the hypothesis is that the origin of life is a moment when these constants intertwined or interacted. Energy from the cosmos interacted with inorganic matter to support matter with retention of this riveted energy, as energy to be circulated within the primitive channelized structures to conserve energy by the materialization of the (...) proton homeostasis mechanisms developed from the obtainable inorganic matter. The driver for these processes as we now confirm, exists in the quantum world and through quantum phenomenal processes could have combined these constants to create the magic of life. Primitive earth was a chemical reactive system that triggered a macromolecular evolution by means of open thermodynamic systems, driven by cyclic gradients of temperature, electromagnetic radiation and chemical potentials which sustained life and proto-consciousness in the first life forms driven by the quantum processes. The origin of life is always an intriguing topic but the purpose for finding the cause should never be inclined towards obliterating it; for if that is the case, the further we seek, the farther it will go. (shrink)

We argue that C. Darwin and more recently W. Hennig worked at times under the simplifying assumption of an eternal biosphere. So motivated, we explicitly consider the consequences which follow mathematically from this assumption, and the infinite graphs it leads to. This assumption admits certain clusters of organisms which have some ideal theoretical properties of species, shining some light onto the species problem. We prove a dualization of a law of T.A. Knight and C. Darwin, and sketch a decomposition result (...) involving the internodons of D. Kornet, J. Metz and H. Schellinx. A further goal of this paper is to respond to B. Sturmfels’ question, “Can biology lead to new theorems?”. (shrink)

Recent work in the psychology of happiness has led some to conclude that we are unreliable assessors of our lives and that skepticism about whether we are happy is a genuine possibility worth taking very seriously. I argue that such claims, if true, have worrisome implications for procreation. In particular, they show that skepticism about whether many if not most people are well positioned to create persons is a genuine possibility worth taking very seriously. This skeptical worry should not be (...) confused with a related but much stronger version of the argument, which says that all human lives are very bad and not worth starting. I criticize the latter stance, but take seriously the former stance and hope it can be answered in future work. (shrink)

Niche construction is a concept that captures a wide array of biological phenomena, from the environmental effects of metabolism to the creation of complex structures such as termite mounds and beaver dams. A central point in niche construction theory is that organisms do not just passively undergo developmental, ecological, or evolutionary processes, but are also active participants in them Evolution: From molecules to men, Cambridge University Press, Cambridge, 1983; Laland KN, Odling-Smee J, Feldman MW, In: KN Laland and T Uller (...) Evolutionary causation: Biological and philosophical reflections, MIT Press, Cambridge, MA, 2019). In this paper, we distinguish between two fundamentally different ways in which organisms are active participants: as agents and as contributors. Roughly, organisms act as agents when niche constructing effects are a result of a goal-directed behavior over which the organisms have some degree of control. Organisms act as contributors when the niche constructing effects do not arise from a goal to perform the constructive activity. As illustrative examples we discuss plants altering leaf-morphology to optimize light exposure as reported by Sultan and bacteria creating novel niches through excreting energy-rich metabolites. The difference between agential and contributional niche construction is important for understanding the different ways organisms can actively participate in development, ecology, and evolution. Additionally, this distinction can increase our understanding of how the capacity of agency is distributed across the tree of life and how agency influences developmental and evolutionary processes. (shrink)

This study focuses on the experimental and philosophical analysis of the meaning of life in death situation, according to Wittgenstein’s way of life and sayings during the war. The method of extraction and analysis of information is grounded theory. For this purpose, Wittgenstein’s writings such as his letters and memories, and other’s texts about his life and his internal moods were analyzed. After analyzing the collected information and categorizing them in frames of open codes, axial codes, etc. (...) we recognized that Wittgenstein's point of view in death situation was supernatural God-centered. By reading Tolstoy gospel and Dostoyevsky's works, Wittgenstein has reached a kind of religious awakening in that period of his life. But before and after the war period he had a naturalistic point of view toward the meaning of life, in which moral values are in the core. (shrink)

The concept of “life” certainly is of some use to distinguish birds and beavers from water and stones. This pragmatic usefulness has led to its construal as a categorical predicate that can sift out living entities from non-living ones depending on their possessing specific properties—reproduction, metabolism, evolvability etc. In this paper, we argue against this binary construal of life. Using text-mining methods across over 30,000 scientific articles, we defend instead a degrees-of-life view and show how these methods (...) can contribute to experimental philosophy of science and concept explication. We apply topic-modeling algorithms to identify which specific properties are attributed to a target set of entities (bacteria, archaea, viruses, prions, plasmids, phages and the molecule of adenine). Eight major clusters of properties were identified together with their relative relevance for each target entity (two that relate to metabolism and catalysis, one to genetics, one to evolvability, one to structure, and—rather unexpectedly—three that concern interactions with the environment broadly construed). While aligning with intuitions—for instance about viruses being less alive than bacteria—these quantitative results also reveal differential degrees of performance that have so far remained elusive or overlooked. Taken together, these analyses provide a conceptual “lifeness space” that makes it possible to move away from a categorical construal of life by empirically assessing the relative lifeness of more-or-less alive entities. (shrink)

1. Some philosophers think that the goodness of a life is determined not only by the goods within that life, but also by the fact that life itself is good [Nagel 1970: 2]: There are elements which...

What could be more inert than mathematical objects? Nothing distinguishes them from rocks and yet, if we examine them in their historical perspective, they don't actually seem to be as lifeless as they do at first. Conceived as they are by humans, they offer a glimpse of the breath that brings them to life. Caught in the web of a language, they cannot extricate themselves from the form that the tensive forces constraining them have given them. While they do (...) not serve a specific biological purpose, they are still, above all, possibilities of life, objects imbued with power. Though they know neither pain nor laughter, their mode or style of existence endows them with a special form of life that structures the givenness, the matter of the other entities in which they participate. Because of this, by intervening in the framework of these entities, mathematical objects condition their form of space, enjoining the entities to submit to a structure that they have not chosen. (shrink)

The concept of life plays a crucial role in the debate on synthetic biology. The first part of this chapter outlines the controversial debate on the status of the concept of life in current science and philosophy. Against this background, synthetic biology and the discourse on its scientific and societal consequences is revealed as an exception. Here, the concept of life is not only used as buzzword but also discussed theoretically and links the ethical aspects with the (...) epistemological prerequisites and the ontological consequences of synthetic biology. The second part examines this point of intersection and analyses some of the issues which are discussed in terms of the concept of life. The third part turns to the history of the concept of life. It offers an examination of scientific and philosophical discourses on life at the turn of the 20th century and suggests a surprising result: In the light of this history, synthetic biology leads to well-known debates, arguments, notions and questions. But it is concluded that the concept of life is too ambiguous and controversial to be useful for capturing the actual practice of synthetic biology. In the fourth part I argue that with regard to the ethical evaluation of synthetic biology, the ambiguity of the concept of life is not as problematic as sometimes held because other challenges are more important. The question whether the activity of synthetic biological systems should be conceived as life or not is primarily theoretical. (shrink)

For Michel Henry, the Cartesian notion of “videre videor” (“I seem to see”) provides the clearest schema of the type of self-affection in which life is experienced, and through which one can provide a properly phenomenological conception of life. It is above all in Henry’s exemplification of the ‘videor’ in terms of affective experience (in undergoing a passion, feeling pain) that one is able to pin down his two principle arguments concerning the nature of this self-affection. The one, (...) regarding the videor as a form of self-awareness, ultimately fails to convince, whereas the same cannot be said for Henry’s analyses of those types of affective experience whose primary characteristic is precisely a form of resistance internal to life itself. This leads to a demonstration of how Henry’s phenomenology of the videor founds an understanding of life that presupposes a form of impotence and limitation, and even finitude, as the very implication of its appearance. (shrink)

The conditions of transport and slaughter at the end of their lives are a major challenge to the welfare of agricultural animals. • End-of-life experiences should be of a greater ethical concern than others of similar intensity and duration, due to their position in the animal’s life. • End-of-life welfare can have both internal importance to the animals and external ethical importance to human decision-makers. • We should pay extra care to ensure that the conditions during transport (...) and slaughter are as positive as possible. (shrink)

I defend origins of life research against an argument, given by Roger White in 2007, that it rests on a mistake. I show how the Bayesian machinery can illuminate the rational search for alternative explanations of currently inexplicable, improbable data, and in particular how it can illuminate the rational search for a secular explanation of the origins of life and of the fine-tuning of the universe.

The odds of encountering a senior citizen selling on the street have increased. The claim that they have no choice but to work and sell on the street, despite the dangers, illnesses, and psychological issues they may face, to provide for their family’s needs is very evident. Therefore, this study explores the quality of life, lived experiences, challenges, and coping mechanisms of senior citizen street vendors in Bulacan, Philippines. The study employed Heideggerian Phenomenology and Interpretative Phenomenological Analysis (IPA). Moreover, (...) the following themes arise (1) Golden years, (2) Socially connected, and (3) Unknown journey. These themes highlighted the experiences and challenges faced by the participants. Moreover, it is highly suggested that local government agencies enhance and strictly monitor the existing program that alleviates mental and physical health concerns and senior citizens' safety and financial assistance. (shrink)

In THE GENEALOGY OF MORALITY Nietzsche assess the value of the value judgments of morality from the perspective of human flourishing. His positive descriptions of the “higher men” he hopes for and the negative descriptions of the decadent humans he thinks morality unfortunately supports both point to a particular substantive conception of what such flourishing comes to. The Genealogy, however, presents us with a puzzle: why does Nietzsche’s own evaluative standard not receive a genealogical critique? The answer to this puzzle, (...) I argue, lies in recognizing the centrality of the notion of “life”, and its connection to power, in Nietzsche’s overall account. Leiter has argued that his “Millian Model” provides the most charitable reconstruction of appeals to a privileged evaluative standard of power; this model ascribes an inference from a strong doctrine of the will to power according to which only power can be desired. I propose a “Benthamite Model” that ascribes an inference from the inescapability of a tendency towards power, a tendency that is essential to life. I argue that this model avoids the objections Leiter directs at the Millian Model. (shrink)

In this paper, I discuss several temporal aspects of paleontology from a philosophical perspective. I begin by presenting the general problem of “taming” deep time to make it comprehensible at a human scale, starting with the traditional geologic time scale: an event-based, relative time scale consisting of a hierarchy of chronological units. Not only does the relative timescale provide a basis for reconstructing many of the general features of the history of life, but it is also consonant with the (...) cognitive processes humans use to think about time. Absolute dating of rocks, fossils, and evolutionary events (such as branching events on the tree of life) can be accomplished through the use of radiometric dating, chronological signals extractable from fossil growth patterns, and the “molecular clock.” Sometimes these different methods of absolute dating, which start from largely independent assumptions and evidentiary bases, converge in their temporal estimates, resulting in a consilience of inductions. At other times they fail to agree, either because fossils and molecules are giving temporal information about different aspects of nature and should not be expected to agree, or because of flawed assumptions that give rise to an inaccurate estimate. I argue that in general, despite the fact that it can be difficult to integrate disparate kinds of evidence, the principle of total evidence should be applied to the dating of evolutionary events. As a historical science, paleontology studies past events we cannot observe directly. This raises questions of epistemic access, meaning that due to the fragmentary nature of the fossil record we may find ourselves without access to the relevant traces to adjudicate between rival hypotheses about the past. The problems and prospects of epistemic access are explored through a case study of the reconstruction of the colors of dinosaurs. The paper closes with a reflection on the Darwin- Lyell metaphor of the fossil record as a highly fragmentary history book, and a call for a reconsideration of the book metaphor in favor of a systems view of the geologic and fossil records. (shrink)

This case study is a retrospection of my family’s experiences that highlight several ELE facets. Following a description, we attempt to explain some of these phenomena from the perspectives of science and other germane disciplines.

Patient-centered care (PCC) is an approach to healthcare that values patients’ preference, need, and autonomy. The estimation of healthcare partly depends on how well PCC is implemented. In addition, the result of clinical research can inform the assessment of the implementation of PCC. In clinical research, health-related quality of life (HRQL) theoretical models offer a conceptual toolbox that informs clinical research and guides the hypotheses generation. Wilson and Cleary (1995) developed the most widely used HRQL theoretical model (Bakas et (...) al., 2012). Ontological assumptions about causation in Wilson and Cleary’s model will influence which kind of hypotheses will be generated. I will argue that Wilson and Cleary’s model instilled a kind of causal bias into hypothesis generation in clinical research on HRQL. Causation from biomedical factors to non-biomedical factors is frequently hypothesized while causation from non-biomedical factors to biomedical factors is rarely hypothesized. It leads to that the interdependence and interaction between constituent parts of patients are ignored, which is an obstacle to the implementation of PCC. In addition, I will propose a revised HRQL theoretical model which avoids the causal bias brought by Wilson and Cleary’s model. By doing so, I leave room for the improvement of the practice of healthcare by analyzing the ontological assumptions about causation. (shrink)

On the shortness of life -- Consolation to Helvia -- On tranquility of mind.

لم يكن العلم يومًا غريبًا عن الفلسفة، بل لقد أدت العلاقة الجدلية المستمرة بينهما إلى مزيد من المصداقية والقبول لبعض النماذج التفسيرية، سواء منها ما كان في الأصل نموذجًا فلسفيًا ثم وجد دعمًا علميًا – كنموذج الذرات والفـراغ عند «ديمرقــريطس» وتبنى النظرية الذرية الحديثة لإطاره العام – أو ما كان منها نموذجًا علميًا تم تداوله فلسفيًا – كنموذج النقاط المادية المتجاذبة عند »نيوتن« وتبنى معظم فلاسفة الحقبة الحديثة له. وفي هذا المقال يهتم الدكتور صلاح عثمان بمناقشة نموذج شجرة الكون لفيلسوف (...) العلم الكندي المعاصر «ستورس مكال»، وأوجه الاختلاف بينه وبين النماذج التفسيرية المماثلة القائمة على فكرة متصل الزمان – مكان، ويُركز على ما يقترحه النموذج من حلٍ لواحدةٍ من أصعب مشكلات العلم والمنطق والفلسفة، ألا وهى مشكلة تحديد شروط الصدق للقضايا المنطقية الشرطية المناقضة للواقع؛ أعني تلك التي لا تُعبر عن حوادث وقعت بالفعل، بل كان من المفترض أن تقع، وبالتالي يصعب تحديد قيمة صدق (صادقة أو كاذبة) لها. هذا النوع من القضايا يرتبط ارتباطًا وثيقًا بتصور القانون العلمي، وتحفل به المقاربات التاريخية والخطط المستقبلية للأفراد والحكومات، لذا تعددت محاولات معالجته من قبل الفلاسفة، وهو ما تجلى مثلاً في النظرية الاستدلالية للقضايا الشرطية التي اقترحها «نيلسون جودمان», ونظرية العقول واعتقاداتها للفيلسوف الإنجليزي «فرانك رامزي», ونظرية العوالم الممكنة للفيلسوفين الأمريكيين المعاصـرين «روبرت ستالنيكر»، و«ديفيد لويس»، وأخيرًا نظرية النموذج الشجري لـ «ستورس مكال». وينتهي المقال إلى نتيجة مؤداها نجاح النموذج في معالجة المشكلة، وإن كان ذلك مرهونًا بالتأكيد على موضوعية قيم الصدق والاحتمال التي تحوزها القضايا الشرطية في مقابل الذات المُدركة، تلك التي تنتقل عبر غُرف انتظار متعددة تقترب رويدًا رويدًا من الحقيقة. . (shrink)

Genes and the Agents of Life undertakes to rethink the place of the individual in the biological sciences, drawing parallels with the cognitive and social sciences. Genes, organisms, and species are all agents of life but how are each of these conceptualized within genetics, developmental biology, evolutionary biology, and systematics? The 2005 book includes highly accessible discussions of genetic encoding, species and natural kinds, and pluralism above the levels of selection, drawing on work from across the biological sciences. (...) The book is a companion to the author's Boundaries of the Mind (2004), also available from Cambridge, where the focus is the cognitive sciences. The book will appeal to a broad range of professionals and students in philosophy, biology, and the history of science. You can download the table of contents and the first chapter here. (shrink)

There has been much debate regarding the 'double-effect' of sedatives and analgesics administered at the end-of-life, and the possibility that health professionals using these drugs are performing 'slow euthanasia.' On the one hand analgesics and sedatives can do much to relieve suffering in the terminally ill. On the other hand, they can hasten death. According to a standard view, the administration of analgesics and sedatives amounts to euthanasia when the drugs are given with an intention to hasten death. In (...) this paper we report a small qualitative study based on interviews with 8 Australian general physicians regarding their understanding of intention in the context of questions about voluntary euthanasia, assisted suicide and particularly the use of analgesic and sedative infusions (including the possibility of voluntary or non-voluntary 'slow euthanasia'). We found a striking ambiguity and uncertainty regarding intentions amongst doctors interviewed. Some were explicit in describing a 'grey' area between palliation and euthanasia, or a continuum between the two. Not one of the respondents was consistent in distinguishing between a foreseen death and an intended death. A major theme was that 'slow euthanasia' may be more psychologically acceptable to doctors than active voluntary euthanasia by bolus injection, partly because the former would usually only result in a small loss of 'time' for patients already very close to death, but also because of the desirable ambiguities surrounding causation and intention when an infusion of analgesics and sedatives is used. The empirical and philosophical implications of these findings are discussed. (shrink)

In the past years, many students had problems with their finances, especially their expenses for education. Many of the students are affected by the crisis financially, emotionally, and by their wellbeing. That is why the government provides programs that will help the students with their problems with school expenses, and that is through the Tertiary Education Subsidy (TES) of the Commission on Higher Education (CHED). Further, the primary goal of this study is to explore the TES Grantees' lived experiences, challenges, (...) and coping mechanisms. Furthermore, these are the study's findings: (1) The grantees find the TES very helpful regarding finances that will tackle their academic needs, such as tuition fees and school learning materials. (2) Many students value government assistance that motivates them to maintain their grades. (shrink)

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: (...) What key questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

Sikhism is a monotheistic religion founded during the 15th century in the Punjab region, by Guru Nanak Dev and continued to progress with ten successive Sikh gurus (the last teaching being the holy scripture Gurū Granth Sāhib Ji). It is the fifth-largest organized religion in the world, with over 30 million Sikhs and one of the most steadily growing. This system of religious philosophy and expression has been traditionally known as the Gurmat (literally 'of the gurus'). The Sikh Scriptures outline (...) the ways in which one can bring their own thinking in line with the Hukam. If one engages in the service of God's creation, this is the best way of working in harmony with the Divine Will. Further, by remembering Waheguru one becomes aware of "God desires" and "Divine essence" within the person is realised. By following these "Divine Values" that benefit His Creation, one ends the cycle of Karma and Transmigration. The objective of this paper is to study the basic life values taught by Sri Guru Gobind Singh ji. (shrink)

As a practicing life scientist, Descartes must have a theory of what it means to be a living being. In this paper, I provide an account of what his theoretical conception of living bodies must be. I then show that this conception might well run afoul of his rejection of final causal explanations in natural philosophy. Nonetheless, I show how Descartes might have made use of such explanations as merely hypothetical, even though he explicitly blocks this move. I conclude (...) by suggesting that there is no reason for him to have blocked the use of hypothetical final causes in this way. (shrink)

The paper aims to clarify the role of the meaning of life in Anselm Müller’s philosophy. Müller says that the ethically good life is the life of acting well, and acting well requires at least a rough conception of the meaning of life, or a conception of what makes a life go well. But why is such a conception required and what does it mean to have such a conception? I argue that such a conception (...) cannot provide us with ultimate ends in our practical deliberations. Nor can its role be merely to provide a standard against which practical reasoning can be assessed. Rather, our conception of the meaning of life is, in the first instance, that which allows us, in our practical reasoning, to see certain considerations as good reasons for certain actions and to weigh reasons for and against different options. One upshot of my interpretation is that Müller should be more optimistic about philosophy’s ability to answer the question of the meaning of life than he allows himself to be. (shrink)

We raise various puzzles about the relationship between God and the meaning of life. These difficulties suggest that, even if we assume that God exists, and even if God’s existence would entail that our lives have meaning, God is not and could not be the source of the meaning of life. We conclude by discussing implications of our arguments: these claims can be used in a novel argument for atheism; these claims undermine an extant argument for God’s existence; (...) and they suggest that atheism is consistent with our lives having meaning. (shrink)

The objective of this paper is to contribute to the international discussions on life and scientific technology by examining the images and concepts of life in contemporary Japan. In English the word Inochi can be rendered as "life". However, the nuances of the Japanese term differ in certain cases, and therefore I have chosen to use the term much as is. I first discuss the linguistic meanings of the word, and then consider several important features of the (...) images of inochi that have appeared in publications and responses from questionnaires on this topic. Some philosophical and metaphysical interpretations of the concept of inochi are then proposed. Finally a brief outline of the study of life is presented, suggesting a new way to approach bioethics and discussions on environmental issues. (shrink)

Drawing upon Husserl and Merleau-Ponty’s phenomenological constitution of the Other through Einfülhung, I argue that the hierarchical distinction between higher and lower animals – which has been dismissed by Heidegger for being anthropocentric – must not be conceived as an objective distinction between “primitive” animals and “more evolved” ones, but rather corresponds to a phenomenological distinction between familiar and unfamiliar animals.

Basant (Spring) is a time of dawning light, new life, new birth, and new hope — a time of warmth, vitality, dancing, and blossoming. Every year she comes out of the cold darkness and captivatingly dances around us. She embraces us with her warmth, intoxicates us with her aroma. Like a potent elixir, spring revitalizes our hope. She breathes life into the dead and teaches us the lessons of renewal and rebirth [1]. The dawn of Basant has well (...) appreciated in Gurbani as; "Among the months, blessed is the month when spring always comes."[Mehl First, SGGS: 1168]; "The delightful season of spring has come." [Mehl First, SGGS: 1168] Every year, the vernal equinox occurs on the 21st of March. It indicates the starting of long, brighter days. The birds trill, bees buzz, and the buds of plants and trees burst forth. Humans stroll with a bit more spring in their step and sparkle in their eyes. Gurbani appreciates the blooming of Spring as; "The season of spring has come. It blossoms forth luxuriantly." [Mehl Fifth, SGGS: 1185] Feeling good in spring is more than psychological. The more extended light period of spring days has the power to change our biochemistry in positive ways. The increased sunlight exposure affects hormonal and metabolic functions. We feel more optimistic and resilient; even our reproductive patterns are affected by the light of spring. (shrink)

The logical problem of artificial intelligence—the question of whether the notion sometimes referred to as ‘strong’ AI is self-contradictory—is, essentially, the question of whether an artificial form of life is possible. This question has an immediately paradoxical character, which can be made explicit if we recast it (in terms that would ordinarily seem to be implied by it) as the question of whether an unnatural form of nature is possible. The present paper seeks to explain this paradoxical kind of (...) possibility by arguing that machines can share the human form of life and thus acquire human mindedness, which is to say they can be intelligent, conscious, sentient, etc. in precisely the way that a human being typically is. (shrink)

Biological organisms, languages and selves are normative entities, so must be understood in terms of norms. Mechanistic understanding is based on causal necessity, but normative understanding relies on a grasp of the contingencies of evolution, history and personal experience.

This article proposes a novel strategy, one that draws on insights from antidiscrimination law, for addressing a persistent challenge in medical ethics and the philosophy of disability: whether health systems can consider quality of life without unjustly discriminating against individuals with disabilities. It argues that rather than uniformly considering or ignoring quality of life, health systems should take a more nuanced approach. Under the article's proposal, health systems should treat cases where quality of life suffers because of (...) disability-focused exclusion or injustice differently from cases where lower quality of life results from laws of nature, resource scarcity, or appropriate tradeoffs. Decisionmakers should ignore quality-of-life losses that result from injustice or exclusion when ignoring them would improve the prospects of individuals with disabilities; in contrast, they should consider quality-of-life losses that are unavoidable or stem from resource scarcity or permissible tradeoffs. On this proposal, while health systems should not amplify existing injustice against individuals with disabilities, they are not required to altogether ignore the potential effects of disability on quality of life. (shrink)