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  1. Rethinking Hereditary Relations: The Reconstitutor as the Evolutionary Unit of Heredity.Sophie J. Veigl, Javier Suárez & Adrian Stencel - 2022 - Synthese 200 (5):1-42.
    This paper introduces the reconstitutor as a comprehensive unit of heredity within the context of evolutionary research. A reconstitutor is the structure resulting from a set of relationships between different elements or processes that are actively involved in the recreation of a specific phenotypic variant in each generation regardless of the biomolecular basis of the elements or whether they stand in a continuous line of ancestry. Firstly, we justify the necessity of introducing the reconstitutor by showing the limitations of other (...)
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  2. From Chance to Choice: Genetics and Justice, by Allen Buchanan, Dan W. Brock, Norman Daniels, & Daniel Wikler. [REVIEW]Louis Caruana - 2005 - Heythrop Journal 46 (4):584-587.
    Scientific knowledge of how genes work is giving human beings unprecedented power to shape future human lives, for better or for worse. People involved in government, business and science are facing new questions related to the application of genetic technologies to human beings. Our technical knowledge is growing fast, but does our moral wisdom grow at the same rate?
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  3. Ethical Issues in Global Neuroimaging Genetics Collaborations.Andrea Palk, Judy Illes, Paul Thompson & D. Stein - 2020 - NeuroImage 117208 (221):1-10.
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  4. Developing Gamified Instructional Materials in Genetics for Grade 12 STEM.Aaron Funa & Jhonner Ricafort - 2019 - International Journal of Engineering Science and Computing 9 (3):20597-20600.
    As technology advances, the demand for innovative instructional materials also increases. As a result, the Department of Education urges teachers to develop instructional materials. This study was conducted at Bulusan National High School, Bulusan, Sorsogon, Philippines SY 2018-2019 which was aimed to develop gamified instructional materials in genetics that would aid in teaching and learning process of grade 12 STEM students. The developed gamified materials were collectively called the GIM in Genetics which is comprised of two parts; namely, Student’s Portfolio (...)
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  5. Genopower: On Genomics, Disability, and Impairment.Joel Michael Reynolds - 2021 - Foucault Studies 31.
    Since the completion of the human genome project in 2003, genomic sequencing, analysis, and interpretation have become staples of research in medicine and the life sciences more generally. While much ink has been spilled concerning genomics’ precipitous rise, there is little agreement among scholars concerning its meaning, both in general and with respect to our current moment. Some claim genomics is neither new, nor noteworthy; others claim it is a novel and worrisome instrument of newgenics. Contrary to the approaches of (...)
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  6. The Circle of Time.Ilexa Yardley - 2021 - Https://Medium.Com/the-Circular-Theory/.
    ‘One’ and ‘Two.’ (Zero and one). Are, technically, circumference and diameter.
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  7. Death Gene as It is Understood by Theology and Genetics.Tudor Cosmin Ciocan & Alina Martinescu - 2014 - Dialogo 1 (1):83-88.
    This paper is trying to put together two different researches, from theology and from genetics, about a general and undetermined topic, death. It is undetermined because no one can say something demonstrable and unequivocal about it, since no person alive can cross over the edge of life and come back from the domain of death with information about it. But we can discuss nevertheless things that are obvious and possible to be reasonably inferred about death even by livings. In this (...)
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  8. Health for Whom? Bioethics and the Challenge of Justice for Genomic Medicine.Joel Michael Reynolds - 2020 - Hastings Center Report 50 (supplement S1):S2-S5.
    The guiding premise from which this special report begins is the conviction and hope that justice is at the normative heart of medicine and that it is the perpetual task of bioethics to bring concerns of justice to bear on medical practice. On such an account, justice is medicine's lifeblood, that by which it contributes to life as opposed to diminishing it. It is in this larger, historical, intersectional, critical, and ethically minded context that we must approach pressing questions facing (...)
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  9. Urbis Et Orbis: Non-Euclidean Space of History.Alex V. Halapsis - 2015 - The European Philosophical and Historical Discourse 1 (2):37-42.
    Social space is superimposed on the civilization map of the world whereas the social time is correlated with the duration of civilization existence. Within own civilization the concept space is non-homogeneous, there are “singled out points” — “concept factories”. As social structures, cities may exist rather long, sometimes during several millennia, but as concept centres they are limited by the duration of civilization existence. If civilization is a “concept universe”, nobody and nothing may cross the boundaries, which include cities as (...)
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  10. Habermas and the Question of Bioethics.Hille Haker - 2019 - European Journal for Philosophy of Religion 11 (4):61-86.
    In The Future of Human Nature, Jürgen Habermas raises the question of whether the embryonic genetic diagnosis and genetic modification threatens the foundations of the species ethics that underlies current understandings of morality. While morality, in the normative sense, is based on moral interactions enabling communicative action, justification, and reciprocal respect, the reification involved in the new technologies may preclude individuals to uphold a sense of the undisposability of human life and the inviolability of human beings that is necessary for (...)
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  11. El gen de la monogamia podría actuar también en humanos.Luis Santiago Lario Herrero - 2008 - Tendencias21 2008.
    Una investigación realizada en humanos ha desvelado la existencia de ciertas variantes genéticas en la conformación del gen AVPR1A que se traducirían en una mayor o menor disposición y aptitud hacia la vida en pareja. Eso significa que la actividad de ese gen influiría en la calidad de la vida conyugal y muy probablemente interferiría en la orientación de nuestro mundo afectivo.
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  12. The Monogamy Gene Could Also Act in Humans.Luis Santiago Lario Herrero - 2008 - Tendencias21 2008.
    Research has revealed that genetic variations in the human gene AVPR1A affect the disposition and aptitude of individuals to live in a relationship. Thus the activity of this gene could influence the quality of marital relationships and very likely our emotional inclinations.
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  13. The Altruism Paradox: A Consequence of Mistaken Genetic Modeling.Yussif Yakubu - 2013 - Biological Theory 8 (1):103-113.
    The theoretical heuristic of assuming distinct alleles (or genotypes) for alternative phenotypes is the foundation of the paradigm of evolutionary explanation we call the Modern Synthesis. In modeling the evolution of sociality, the heuristic has been to set altruism and selfishness as alternative phenotypes under distinct genotypes, which has been dubbed the “phenotypic gambit.” The prevalence of the altruistic genotype that is of lower evolutionary fitness relative to the alternative genotype for non-altruistic behavior in populations is the basis of the (...)
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  14. Prisoners of Abstraction? The Theory and Measure of Genetic Variation, and the Very Concept of 'Race'.Jonathan Michael Kaplan & Rasmus Grønfeldt Winther - 2013 - Biological Theory 7 (1):401-412.
    It is illegitimate to read any ontology about "race" off of biological theory or data. Indeed, the technical meaning of "genetic variation" is fluid, and there is no single theoretical agreed-upon criterion for defining and distinguishing populations (or groups or clusters) given a particular set of genetic variation data. Thus, by analyzing three formal senses of "genetic variation"—diversity, differentiation, and heterozygosity—we argue that the use of biological theory for making epistemic claims about "race" can only seem plausible when it relies (...)
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  15. Genetic Determinism and the Innate-Acquired Distinction.Maria Kronfeldner - 2009 - Medicine Studies 1 (2):167-181.
    This article illustrates in which sense genetic determinism is still part of the contemporary interactionist consensus in medicine. Three dimensions of this consensus are discussed: kinds of causes, a continuum of traits ranging from monogenetic diseases to car accidents, and different kinds of determination due to different norms of reaction. On this basis, this article explicates in which sense the interactionist consensus presupposes the innate?acquired distinction. After a descriptive Part 1, Part 2 reviews why the innate?acquired distinction is under attack (...)
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  16. Genetic Variance–Covariance Matrices: A Critique of the Evolutionary Quantitative Genetics Research Program.Massimo Pigliucci - 2006 - Biology and Philosophy 21 (1):1-23.
    This paper outlines a critique of the use of the genetic variance–covariance matrix (G), one of the central concepts in the modern study of natural selection and evolution. Specifically, I argue that for both conceptual and empirical reasons, studies of G cannot be used to elucidate so-called constraints on natural selection, nor can they be employed to detect or to measure past selection in natural populations – contrary to what assumed by most practicing biologists. I suggest that the search for (...)
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  17. On the Limits of Quantitative Genetics for the Study of Phenotypic Evolution.Massimo Pigliucci & Carl D. Schlichting - 1997 - Acta Biotheoretica 45 (2):143-160.
    During the last two decades the role of quantitative genetics in evolutionary theory has expanded considerably. Quantitative genetic-based models addressing long term phenotypic evolution, evolution in multiple environments (phenotypic plasticity) and evolution of ontogenies (developmental trajectories) have been proposed. Yet, the mathematical foundations of quantitative genetics were laid with a very different set of problems in mind (mostly the prediction of short term responses to artificial selection), and at a time in which any details of the genetic machinery were virtually (...)
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Classical Genetics
  1. Of Stirps and Chromosomes: Generality Through Detail.Charles H. Pence - 2022 - Studies in History and Philosophy of Science Part A 94:177-190.
    One claim found in the received historiography of the biometrical school (comprised primarily of Francis Galton, Karl Pearson, and W. F. R. Weldon) is that one of the biometricians' great flaws was their inability to look past their population-focused, statistical, gradualist understanding of evolutionary change – which led, in part, to their ignoring developments in cellular biology around 1900. I will argue, on the contrary, that the work of the biometricians was, from its earliest days, fundamentally concerned with connections between (...)
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  2. Beyond Mendelism and Biometry.Yafeng Shan - 2021 - Studies in History and Philosophy of Science Part A 89:155-163.
    Historiographical analyses of the development of genetics in the first decade of the 20th century have been to a great extent framed in the context of the Mendelian-Biometrician controversy. Much has been discussed on the nature, origin, development, and legacy of the controversy. However, such a framework is becoming less useful and fruitful. This paper challenges the traditional historiography framed by the Mendelian-Biometrician distinction. It argues that the Mendelian-Biometrician distinction fails to reflect the theoretical and methodological diversity in the controversy. (...)
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  3. Mendel on Developmental Information.Yafeng Shan - 2021 - In Chris Meyns (ed.), Information and the History of Philosophy. London: Routledge. pp. 262-280.
    It has been widely received that one of Gregor Mendel’s most important contributions to the history of genetics is his novel work on developmental information (for example, the proposal of the famous Mendelian ratios like 1:2:1, 3:1, and 9:3:3:1). This view is well evidenced by the fact that much of early Mendelians’ work in the 1900s focuses on the retrodiction (viz. the re-analysis of the pre-exist data with Mendel’s approach). However, there is no consensus on what Mendel meant by development (...)
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  4. Die Architektur der Synthese. Entstehung und Philosophie der modernen Evolutionstheorie.Marcel Weber - 1996 - Dissertation, University of Konstanz
    This Ph.D. thesis provides a pilosophical account of the structure of the evolutionary synthesis of the 1930s and 40s. The first, more historical part analyses how classical genetics came to be integrated into evolutionary thinking, highlighting in particular the importance of chromosomal mapping of Drosophila strains collected in the wild by Dobzansky, but also the work of Goldschmidt, Sumners, Timofeeff-Ressovsky and others. The second, more philosophical part attempts to answer the question wherein the unity of the synthesis consisted. I argue (...)
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  5. Kuhn’s “Wrong Turning” and Legacy Today.Yafeng Shan - 2020 - Synthese 197 (1):381-406.
    Alexander Bird indicates that the significance of Thomas Kuhn in the history of philosophy of science is somehow paradoxical. On the one hand, Kuhn was one of the most influential and important philosophers of science in the second half of the twentieth century. On the other hand, nowadays there is little distinctively Kuhn’s legacy in the sense that most of Kuhn’s work has no longer any philosophical significance. Bird argues that the explanation of the paradox of Kuhn’s legacy is that (...)
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  6. El genoma de los filósofos.Enrique Morata (ed.) - 2015 - Bubok.
    Trying to understand the genome with the classical philosophers. ISBN 978-84-686-6311-1, Bubok, 2015.This book cannot be download at Philpapers due to its 240 MB size . It can be read and download at the web Scribd.
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  7. Darwinland.Enrique Morata (ed.) - 2014 - America Star Books.
    A briefing of the book "Darwinland" , America Star, 2014.
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  8. Antes del universo.Enrique Morata - 2014 - Scribd.
    On the current fashion to look after a previous universe to explain the laws of our Universe.Esperando al nuevo Aristóteles, regreso a Henri Bergson y el "Parménides", el otro universo de Plotino. In Spanish.
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  9. THE HYBRIDIZATION WORK OF MENDEL, 102 YEARS AFTER STARTING THE CONTROVERSY.Rafael María Román-Bravo, Rogelio Garcidueñas-Piña, Ruy Ortiz-Rodríguez, Atilio Miguel Atencio-León, Luis Fabian Yáñez-Cuéllar & Jose Atilio Aranguren-Méndez - 2014 - Revista Cientifica, FCV-LUZ 24 (1):38-46.
    This research was carried out in order to verify by simulation Mendel’s laws and seek for the clarification, from the author’s point of view, the Mendel-Fisher controversy. It was demonstrated from: the experimental procedure and the first two steps of the Hardy-Weinberg law, that the null hypothesis in such experiments is absolutely and undeniably true. Consequently, repeating hybridizing experiments as those showed by Mendel, it makes sense to expect a highly coincidence between the observed and the expected cell frequencies. By (...)
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  10. Ejemplares, modelos y principios en la genética clásica.Pablo Lorenzano - 2005 - Scientiae Studia 3 (2):185-203.
    Taking as starting point Kuhn’s analysis of science textbooks and its application to Sinnott and Dunn’s (1925), it will be discussed the problem of the existence of laws in biology. In particular, it will be showed, in accordance with the proposals of Darden (1991) and Schaffner (1980, 1986, 1993), the relevance of the exemplars, diagrammatically or graphically represented, in the way in which is carried out the teaching and learning process of classical genetics, inasmuch as the information contained in them, (...)
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  11. Experimentation Versus Theory Choice: A Social-Epistemological Approach.Marcel Weber - 2011 - In Hans Bernhard Schmid, Daniel Sirtes & Marcel Weber (eds.), Collective Epistemology. Ontos. pp. 20--203.
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Classical and Molecular Genetics
  1. Of Stirps and Chromosomes: Generality Through Detail.Charles H. Pence - 2022 - Studies in History and Philosophy of Science Part A 94:177-190.
    One claim found in the received historiography of the biometrical school (comprised primarily of Francis Galton, Karl Pearson, and W. F. R. Weldon) is that one of the biometricians' great flaws was their inability to look past their population-focused, statistical, gradualist understanding of evolutionary change – which led, in part, to their ignoring developments in cellular biology around 1900. I will argue, on the contrary, that the work of the biometricians was, from its earliest days, fundamentally concerned with connections between (...)
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  2. The Meaning of "Cause" in Genetics.Kate E. Lynch - 2021 - Combining Human Genetics and Causal Inference to Understand Human Disease and Development. Cold Spring Harbor Perspectives in Medicine.
    Causation has multiple distinct meanings in genetics. One reason for this is meaning slippage between two concepts of the gene: Mendelian and molecular. Another reason is that a variety of genetic methods address different kinds of causal relationships. Some genetic studies address causes of traits in individuals, which can only be assessed when single genes follow predictable inheritance patterns that reliably cause a trait. A second sense concerns the causes of trait differences within a population. Whereas some single genes can (...)
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  3. Genetics, Epigenetics, Paragenetics: Getting Closer to Life.Bhakti Madhava Puri - 2014 - The Harmonizer.
    Gregor Mendel (1822-1884) was the first to explain that certain 'traits' were inherited in plants from one generation to the next. These would later become known as genes. Frederich Miescher in 1869 analyzed a substance from the nucleus of cells, which he therefore called nuclein. Further study of nuclein revealed that it contained elements like hydrogen, oxygen, nitrogen and phosphorous, with a specific ratio of nitrogen to phosphorous. Then in 1878 Albrecht Kossel determined that nuclein contained nucleic acid, from which (...)
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  4. Beyond Quantitative and Qualitative Traits: Three Telling Cases in the Life Sciences.Davide Serpico - 2020 - Biology and Philosophy 35 (3):1-26.
    This paper challenges the common assumption that some phenotypic traits are quantitative while others are qualitative. The distinction between these two kinds of traits is widely influential in biological and biomedical research as well as in scientific education and communication. This is probably due to both historical and epistemological reasons. However, the quantitative/qualitative distinction involves a variety of simplifications on the genetic causes of phenotypic variability and on the development of complex traits. Here, I examine three cases from the life (...)
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  5. La differenza tra ereditarietà ed ereditabilità nello studio dei tratti psicologici.Davide Serpico - 2020 - Medicalive Magazine 6 (1):7-21.
    ITA: In questo articolo analizzerò la differenza tra il concetto di ereditarietà e quello di ereditabilità. In primo luogo, evidenzierò come i due concetti derivino storicamente da differenti tradizioni nello studio della variabili-tà fenotipica e del rapporto genotipo-fenotipo. Secondariamente, illustrerò gli aspetti teorici e metodologici alla base dei due concetti, che sono peraltro collegati a differenti aree delle scienze biologiche. Infine, spigherò brevemente come si sia recentemente tentato, con molte difficoltà, di connettere lo studio dei meccanismi dell’ereditarietà allo studio dell’ereditabilità. (...)
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  6. Re-Examining the Gene in Personalized Genomics.Jordan Bartol - 2013 - Science & Education 22 (10):2529-2546.
    Personalized genomics companies (PG; also called ‘direct-to-consumer genetics’) are businesses marketing genetic testing to consumers over the Internet. While much has been written about these new businesses, little attention has been given to their roles in science communication. This paper provides an analysis of the gene concept presented to customers and the relation between the information given and the science behind PG. Two quite different gene concepts are present in company rhetoric, but only one features in the science. To explain (...)
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  7. Effect of Trigona Honey to mRNA Expression of Interleukin-6 on Salmonella Typhi Induced of BALB/C Mice.Yuliana Syam, Rosdiana Natsir, Sutji Pratiwi Rahardjo, Andi Nilawati Usman, Ressy Dwiyanti & Mochammad Hatta - 2016 - American Journal of Microbiological Research 4 (3):77-80.
    Weak inflammatory response after Salmonella infection can cause persistent infection and facilitate the long survival of pathogens. Honey can induce key immunomodulators such as TNF-α, interleukin-6 (IL-6) and IL-1, that it can be used in the treatment of bacterial infectious diseases caused by Salmonella typhi. The purpose of this study is to determine the effect of honey on the mRNA expression of IL-6 in Salmonella enterica Typhi induced of BABL/c mice. The study used experimental pretest-posttest control design. Honey treatment was (...)
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  8. THE HYBRIDIZATION WORK OF MENDEL, 102 YEARS AFTER STARTING THE CONTROVERSY.Rafael María Román-Bravo, Rogelio Garcidueñas-Piña, Ruy Ortiz-Rodríguez, Atilio Miguel Atencio-León, Luis Fabian Yáñez-Cuéllar & Jose Atilio Aranguren-Méndez - 2014 - Revista Cientifica, FCV-LUZ 24 (1):38-46.
    This research was carried out in order to verify by simulation Mendel’s laws and seek for the clarification, from the author’s point of view, the Mendel-Fisher controversy. It was demonstrated from: the experimental procedure and the first two steps of the Hardy-Weinberg law, that the null hypothesis in such experiments is absolutely and undeniably true. Consequently, repeating hybridizing experiments as those showed by Mendel, it makes sense to expect a highly coincidence between the observed and the expected cell frequencies. By (...)
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  9. Mechanism Schemas and the Relationship Between Biological Theories.Tudor M. Baetu - 2011 - In Phyllis McKay Illari Federica Russo (ed.), Causality in the Sciences. Oxford University Press.
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Genotypes and Phenotypes
  1. The Meaning of "Cause" in Genetics.Kate E. Lynch - 2021 - Combining Human Genetics and Causal Inference to Understand Human Disease and Development. Cold Spring Harbor Perspectives in Medicine.
    Causation has multiple distinct meanings in genetics. One reason for this is meaning slippage between two concepts of the gene: Mendelian and molecular. Another reason is that a variety of genetic methods address different kinds of causal relationships. Some genetic studies address causes of traits in individuals, which can only be assessed when single genes follow predictable inheritance patterns that reliably cause a trait. A second sense concerns the causes of trait differences within a population. Whereas some single genes can (...)
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  2. L'intelligenza tra natura e cultura.Davide Serpico - 2022 - Turin: Rosenberg & Sellier.
    ENG: We all have our own ideas about what it is like to be intelligent. Indeed, even the experts disagree on this topic. This has generated diverse theories on the nature of intelligence and its genetic and environmental bases. Many scientific and philosophical questions thus remain unaddressed: is it possible to characterize intelligence in scientific terms? What do IQ tests measure? How is intelligence influenced by genetics, epigenetics, and the environment? What are the ethical and social implications of the research (...)
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  3. THE NATURE/CULTURE DIVIDE: A Difference in Degree or in Kind?Iñaki Xavier Larrauri Pertierra - 2020 - InCircolo - Rivista di Filosofia E Culture 10 (1):290-306.
    This essay explores the relation between nature and culture and analyses it from the perspective of contemporary evolutionary theory. Both animals and humans are conceived of as attaining both natural and cultural features that interact with each other on a number of levels of varying complexity: nature as cultural, nature as influenced by culture, culture as natural, and culture as influenced by nature. “Nature as cultural” is meant to express a decoupling of behavioral/phenotypic changes of an organism from its genetic (...)
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  4. 评论"我们硬连线吗?克拉克·格兰斯坦·牛津 (2000) (Review of “Are We Hardwired? by Clark & Grunstein (2000)) (修订2019).Michael Richard Starks - 2020 - In 欢迎来到地球上的地狱: 婴儿,气候变化,比特币,卡特尔,中国,民主,多样性,养成基因,平等,黑客,人权,伊斯兰教,自由主义,繁荣,网络,混乱。饥饿,疾病,暴力,人工智能,战争. Las Vegas, NV USA: Reality Press. pp. 82-84.
    这是一个对行为上基因/环境相互作用的极好的回顾,尽管有点过时,但却是一个简单而值得阅读的。他们从双胞胎研究开始,这些研究显示了遗传学对行为的压倒性影响。他们注意到朱迪思·哈里斯越来越广为人知的研究,这 些研究扩展并总结了共享家庭环境对行为几乎没有影响的事实,领养的孩子长大后与选择的继兄弟姐妹一样不同。随机。一个基本点,他们(和几乎所有谁讨论行为遗传学)没有注意到的是,数百(取决于你的观点)人类行为普 遍性,包括我们个性的所有基本,是由我们的基因100%决定,与法线没有变化。每个人都把树看成一棵树,而不是一块石头,寻找和吃食物,生气和嫉妒等等。因此,他们主要讨论的是,环境(文化)能在多大程度上影响各 种特征的显示程度,而不是它们的外观。 最后,他们以通常的政治正确方式讨论优生学,没有注意到我们和所有生物体是自然优生学的产物,并且试图用医学、农业和整个文明来击败自然选择,灾难性的任何社会,坚持这样做。多达50%的所有受孕,或大约1亿/年 ,以早期自然流产结束,几乎所有的母亲都没有意识到。这种对缺陷基因的自然剔除推动了进化,使我们相对地保持遗传健康,并使社会成为可能。基因足以破坏文明,但人口过剩会先破坏文明。 那些希望从现代两个系统的观点来看为人类行为建立一个全面的最新框架的人,可以查阅我的书《路德维希的哲学、心理学、Min d和语言的逻辑结构》维特根斯坦和约翰·西尔的二等奖(2019年)。那些对我更多的作品感兴趣的人可能会看到《会说话的猴子——一个末日星球上的哲学、心理学、科学、宗教和政治——文章和评论2006-2017 年'3rd ed(2019)。.
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  5. Beyond Quantitative and Qualitative Traits: Three Telling Cases in the Life Sciences.Davide Serpico - 2020 - Biology and Philosophy 35 (3):1-26.
    This paper challenges the common assumption that some phenotypic traits are quantitative while others are qualitative. The distinction between these two kinds of traits is widely influential in biological and biomedical research as well as in scientific education and communication. This is probably due to both historical and epistemological reasons. However, the quantitative/qualitative distinction involves a variety of simplifications on the genetic causes of phenotypic variability and on the development of complex traits. Here, I examine three cases from the life (...)
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  6. An Invitation to Explore Unexamined Shifts and Variety in the Meanings of Genotype and Phenotype, and Their Distinction.Peter J. Taylor - 2018 - Philosophy, Theory, and Practice in Biology 10 (6).
    Noting minimal philosophical attention to the shift of the meanings of “genotype” and “phenotype,” and their distinction, as well as to the variety of meanings that have co-existed over the last hundred years, this note invites readers to join in exploring the implications of shifts that have been left unexamined.
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  7. Finding Our Way Through Phenotypes.Andrew R. Deans, Suzanna E. Lewis, Eva Huala, Salvatore S. Anzaldo, Michael Ashburner, James P. Balhoff, David C. Blackburn, Judith A. Blake, J. Gordon Burleigh, Bruno Chanet, Laurel D. Cooper, Mélanie Courtot, Sándor Csösz, Hong Cui, Barry Smith & Others - 2015 - PLoS Biol 13 (1):e1002033.
    Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...)
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  8. FRUSTRATION: PHYSICO-CHEMICAL PREREQUISITES FOR THE CONSTRUCTION OF A SYNTHETIC CELL.Antoine Danchin & Agnieszka Sekowska - 2008 - In Martin G. Hicks and Carsten Kettner (ed.), Proceedings of the International Beilstein Symposium on Systems Chemistry May 26th – 30th, 2008 Bozen, Italy. Beilstein Institute. pp. 1-19.
    To construct a synthetic cell we need to understand the rules that permit life. A central idea in modern biology is that in addition to the four entities making reality, matter, energy, space and time, a fifth one, information, plays a central role. As a consequence of this central importance of the management of information, the bacterial cell is organised as a Turing machine, where the machine, with its compartments defining an inside and an outside and its metabolism, reads and (...)
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  9. Military Genomic Testing: Proportionality, Expected Benefits, and the Connection Between Genotypes and Phenotypes.Charles H. Pence - 2015 - Journal of Law and the Biosciences 2 (1):85-91.
    Mehlman and Li offer a framework for approaching the bioethical issues raised by the military use of genomics that is compellingly grounded in both the contemporary civilian and military ethics of medical research, arguing that military commanders must be bound by the two principles of paternal- ism and proportionality. I agree fully. But I argue here that this is a much higher bar than we may fully realize. Just as the principle of proportionality relies upon a thorough assessment of harms (...)
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  10. The Dispositional Genome: Primus Inter Pares.Christopher J. Austin - 2015 - Biology and Philosophy 30 (2):227-246.
    According to the proponents of Developmental Systems Theory and the Causal Parity Thesis, the privileging of the genome as “first among equals” with respect to the development of phenotypic traits is more a reflection of our own heuristic prejudice than of ontology - the underlying causal structures responsible for that specified development no more single out the genome as primary than they do other broadly “environmental” factors. Parting with the methodology of the popular responses to the Thesis, this paper offers (...)
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  11. Unifying Diseases From a Genetic Point of View: The Example of the Genetic Theory of Infectious Diseases.Marie Darrason - 2013 - Theoretical Medicine and Bioethics 34 (4):327-344.
    In the contemporary biomedical literature, every disease is considered genetic. This extension of the concept of genetic disease is usually interpreted either in a trivial or genocentrist sense, but it is never taken seriously as the expression of a genetic theory of disease. However, a group of French researchers defend the idea of a genetic theory of infectious diseases. By identifying four common genetic mechanisms (Mendelian predisposition to multiple infections, Mendelian predisposition to one infection, and major gene and polygenic predispositions), (...)
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  12. Selection Without Replicators: The Origin of Genes, and the Replicator/Interactor Distinction in Etiobiology.John S. Wilkins, Ian Musgrave & Clem Stanyon - 2012 - Biology and Philosophy 27 (2):215-239.
    Genes are thought to have evolved from long-lived and multiply-interactive molecules in the early stages of the origins of life. However, at that stage there were no replicators, and the distinction between interactors and replicators did not yet apply. Nevertheless, the process of evolution that proceeded from initial autocatalytic hypercycles to full organisms was a Darwinian process of selection of favourable variants. We distinguish therefore between Neo-Darwinian evolution and the related Weismannian and Central Dogma divisions, on the one hand, and (...)
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  13. Genotype–Phenotype Mapping and the End of the ‘Genes as Blueprint’ Metaphor.Massimo Pigliucci - 2010 - Philosophical Transactions Royal Society B 365:557–566.
    In a now classic paper published in 1991, Alberch introduced the concept of genotype–phenotype (G!P) mapping to provide a framework for a more sophisticated discussion of the integration between genetics and developmental biology that was then available. The advent of evo-devo first and of the genomic era later would seem to have superseded talk of transitions in phenotypic space and the like, central to Alberch’s approach. On the contrary, this paper shows that recent empirical and theoretical advances have only sharpened (...)
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