As a contribution to a wider discussion on moral discernment in theological anthropology, this paper seeks to answer the question “What is the impact of mental illness on an individual’s ability to make moral decisions?” Written from a clinical psychiatric perspective, it considers recent contributions from psychology, neuropsychology and imaging technology. It notes that the popular conception that mental illness necessarily robs an individual of moral responsibility is largely unfounded. Most people who suffer from mental health problems do not lose (...) the capacity to make moral decisions, and mental illness on its own rarely explains anti-social or criminal behaviour. Moreover, the assumptions of some scientists, that recent developments in neuropsychology and brain imaging suggest biological determinism, must be treated with caution. (shrink)

We are developing the Neurological Disease Ontology (ND) to provide a framework to enable representation of aspects of neurological diseases that are relevant to their treatment and study. ND is a representational tool that addresses the need for unambiguous annotation, storage, and retrieval of data associated with the treatment and study of neurological diseases. ND is being developed in compliance with the Open Biomedical Ontology Foundry principles and builds upon the paradigm established by the Ontology for General Medical Science (OGMS) (...) for the representation of entities in the domain of disease and medical practice. Initial applications of ND will include the annotation and analysis of large data sets and patient records for Alzheimer’s disease, multiple sclerosis, and stroke. (shrink)

We have begun work on two separate but related ontologies for the study of neurological diseases. The first, the Neurological Disease Ontology (ND), is intended to provide a set of controlled, logically connected classes to describe the range of neurological diseases and their associated signs and symptoms, assessments, diagnoses, and interventions that are encountered in the course of clinical practice. ND is built as an extension of the Ontology for General Medical Sciences — a high-level candidate OBO Foundry ontology that (...) provides a set of general classes that can be used to describe general aspects of medical science. ND is being built with classes utilizing both textual and axiomatized definitions that describe and formalize the relations between instances of other classes within the ontology itself as well as to external ontologies such as the Gene Ontology, Cell Ontology, Protein Ontology, and Chemical Entities of Biological Interest. In addition, references to similar or associated terms in external ontologies, vocabularies and terminologies are included when possible. Initial work on ND is focused on the areas of Alzheimer’s and other diseases associated with dementia, multiple sclerosis, and stroke and cerebrovascular disease. Extensions to additional groups of neurological diseases are planned. The second ontology, the Neuro-Psychological Testing Ontology (NPT), is intended to provide a set of classes for the annotation of neuropsychological testing data. The intention of this ontology is to allow for the integration of results from a variety of neuropsychological tests that assay similar measures of cognitive functioning. Neuro-psychological testing is an important component in developing the clinical picture used in the diagnosis of patients with a range of neurological diseases, such as Alzheimer’s disease and multiple sclerosis, and following stroke or traumatic brain injury. NPT is being developed as an extension to the Ontology for Biomedical Investigations. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Job motivation remains an area of concern among researchers due to the rising issues of poor or lack of motivation among workers. This refers to one’s personal will or drives to perform a task at work. Meanwhile, job satisfaction refers to an employee’s sense of fulfillment with his or her work experience. Therefore, the current study utilized the descriptive- correlational research design to investigate the impact of job motivation on the job satisfaction of accountants. To gather essential data and achieve (...) the objectives of the study, Multidimensional Work Motivational Scale (MWMS) and Minnesota Satisfaction Questionnaire (MSQ) were administered to the target respondents. The collected data were then analyzed using a Multiple Regression Analysis; findings revealed that job motivation has a significant impact on the job satisfaction of accountants. Additionally, the results of this study were carefully evaluated and discussed, and recommendations were made to benefit the stakeholders of the study and contribute to the existing body of knowledge. (shrink)

According to one large family of views, scientific explanations explain a phenomenon (such as an event or a regularity) by subsuming it under a general representation, model, prototype, or schema (see Bechtel, W., & Abrahamsen, A. (2005). Explanation: A mechanist alternative. Studies in History and Philosophy of Biological and Biomedical Sciences, 36(2), 421–441; Churchland, P. M. (1989). A neurocomputational perspective: The nature of mind and the structure of science. Cambridge: MIT Press; Darden (2006); Hempel, C. G. (1965). Aspects of scientific (...) explanation. In C. G. Hempel (Ed.), Aspects of scientific explanation (pp. 331–496). New York: Free Press; Kitcher (1989); Machamer, P., Darden, L., & Craver, C. F. (2000). Thinking about mechanisms. Philosophy of Science, 67(1), 1–25). My concern is with the minimal suggestion that an adequate philosophical theory of scientific explanation can limit its attention to the format or structure with which theories are represented. The representational subsumption view is a plausible hypothesis about the psychology of understanding. It is also a plausible claim about how scientists present their knowledge to the world. However, one cannot address the central questions for a philosophical theory of scientific explanation without turning one’s attention from the structure of representations to the basic commitments about the worldly structures that plausibly count as explanatory. A philosophical theory of scientific explanation should achieve two goals. The first is explanatory demarcation. It should show how explanation relates with other scientific achievements, such as control, description, measurement, prediction, and taxonomy. The second is explanatory normativity. It should say when putative explanations succeed and fail. One cannot achieve these goals without undertaking commitments about the kinds of ontic structures that plausibly count as explanatory. Representations convey explanatory information about a phenomenon when and only when they describe the ontic explanations for those phenomena. (shrink)

ABSTRACT: This paper develops an account of what it is for a proposition to be self- evident to someone, based on the idea that certain propositions are such that to fully understand them is to believe them. It argues that when a proposition p is self-evident to one, one has non-inferential a priori justification for believing that p and, a welcome feature, a justification that does not involve exercising any special sort of intuitive faculty; if, in addition, it is true (...) that p and there exists no reason to believe that the proposition that p is incoherent, then one knows a priori that p. The paper argues that certain deeply contingent truths, e.g., the truth that I would now express by saying “I exist”, can be self-evident to, and thus known a priori by, the person they are about at the time they are about; but, since they cannot be known a priori, or even expressed, by anyone else or at any other time, they should not count as a priori truths. (shrink)

Critical notice of Images of Science by P. M. Churchland and C. A. Hooker.

I resolve an argument over “flat” versus “dimensioned” theories of realization. The theories concern, in part, whether realized and realizing properties are instantiated by the same individual (the flat theory) or different individuals in a part-whole relationship (the dimensioned theory). Carl Gillett has argued that the two views conflict, and that flat theories should be rejected on grounds that they fail to capture scientific cases involving a dimensioned relation between individuals and their constituent parts. I argue on the contrary (...) that the two types of theory complement one another, even on the same range of scientific cases. I illustrate the point with two popular functionalist versions of flat and dimensioned positions – causal-role functionalism and a functional analysis by decomposition – that combine into a larger picture I call “comprehensive functional realization.” I also respond to some possible objections to this synthesis of functionalist views. (shrink)

Thomas Polger and Laurence Shapiro argue that Carl Gillett's much publicized dimensioned theory of realization is incoherent, being subject to a reductio. Their argument turns on the fact that Gillett's definition of realization makes property instances the exclusive relata of the realization relation, while his belief in multiple realization implies its denial, namely, that properties are the relata of the realization relation on occasions of multiple realization. Others like Sydney Shoemaker have also expressed their view of realization in terms (...) of property instances, yet they too have accepted the multiple realizability of properties. Thus I am interested in the more general issue raised by Polger and Shapiro's argument. Specifically, I show how to supplement a theory of realization with a category-inclusive auxiliary assumption, which avoids the stated reductio. I then offer a few reasons to justify the proposed category-inclusive view of realization, making some comparisons to supervenience and causation along the way. (shrink)

Psychoanalytic self-psychology as outlined by such depth psychologists as Jung, Fordham, Winnicott and Kohut provide a framework for conceptualizing a relationship of complementarity between psychic and immune defence as well as loss of bodily and self integration in disease. Physicist Erwin Schrödinger’s thesis that the so-called “arrow of time” does not necessarily deal a mortal blow to its creator is reminiscent of the concept of timeless dimensions of the unconscious mind and the Self in Analytical Psychology, manifest for instance, in (...) dream content and archetypal symbols. These notions are not only consistent with the concepts of timelessness and meaningful coincidence (synchronicity) in psychoanalysis. They are also implicitly spiritual with intimations of a numinous dimension of the evolutionary process in which humanity participates. This includes the idea that an evolving God becomes conscious through and is completed by humankind in a process (Incarnational) theology which regards the numinous as both immanent and transcendent. And concepts of mind which transcend the individual in a transpersonal sense. The treatment of the psychophysical problem by depth psychologist Carl Jung and physicist Wolfgang Pauli with their notion of the unconscious archetypes as timeless, cosmic ordering and regulating principles creating a bridge between mind and matter in a relationship of complementarity is compatible with such a perspective on the numinous which might in turn be useful for contemporary theology and spirituality. (shrink)

The purpose of the study. The aims of this research are to determine the teachers' reading style, determine their reading speed, and determine which reading methods are the teachers' strengths and weaknesses utilizing a thorough evaluation of reading techniques from Hawker Brownlow Education. This study utilized the comprehensive assessment of reading strategies from Hawker Brownlow Education. This material is composed of four series of tests namely, Reading Comprehension 1- Historical Fiction, Reading Comprehension 2- History Article, Reading Comprehension 3- Kate Wrote (...) About a Special Zoo, and Reading Comprehension 4- Email written by Carl with different reading passages using the same 12 reading strategies. It is found that readers can effectively comprehend when they use the following strategies namely, finding word meaning in context, understanding sequence, and making predictions. Therefore, the four series of assessments, show that there are varied ways of comprehending a material that might directly influence the duration and time limit allocated in reading and answering the material, the recurring events of the same material used, and the scheduling of reading comprehension tests. (shrink)

In telling the story of Thomas Willis and the collective investigations of body and brain in 17th-century England with tremendous energy and enthusiasm, journalist Carl Zimmer has written one of the best recent books of popular history of science. The full range of readers will be rewarded by Zimmer’s synthetic scholarship and his evident pleasure in the language of the primary texts. While he owes much to the work of Robert Frank and Robert Martensen in particular, Zimmer has negotiated (...) a vast secondary literature on the major figures of early modern natural philosophy. His decision not to discuss scholarly controversy directly, but rather ‘to give accounts of these people that were consistent with the current consensus’ (p.304) is understandable given the mass market at which he has successfully aimed: yet such a voice would bring a welcome freshness to specialists’ debates. (shrink)

Carl Hempel (1965) argued that probabilistic hypotheses are limited in what they can explain. He contended that a hypothesis cannot explain why E is true if the hypothesis says that E has a probability less than 0.5. Wesley Salmon (1971, 1984, 1990, 1998) and Richard Jeffrey (1969) argued to the contrary, contending that P can explain why E is true even when P says that E’s probability is very low. This debate concerned noncontrastive explananda. Here, a view of contrastive (...) causal explanation is described and defended. It provides a new limit on what probabilistic hypotheses can explain; the limitation is that P cannot explain why E is true rather than A if P assign E a probability that is less than or equal to the probability that P assigns to A. The view entails that a true deterministic theory and a true probabilistic theory that apply to the same explanandum partition are such that the deterministic theory explains all the true contrastive propositions constructable from that partition, whereas the probabilistic theory often fails to do so. (shrink)

Many contemporary epistemologists hold that a subject S’s true belief that p counts as knowledge only if S’s belief that p is also, in some important sense, safe. I describe accounts of this safety condition from John Hawthorne, Duncan Pritchard, and Ernest Sosa. There have been three counterexamples to safety proposed in the recent literature, from Comesaña, Neta and Rohrbaugh, and Kelp. I explain why all three proposals fail: each moves fallaciously from the fact that S was at epistemic (...) risk just before forming her belief to the conclusion that S’s belief was formed unsafely. In light of lessons from their failure, I provide a new and successful counterexample to the safety condition on knowledge. It follows, then, that knowledge need not be safe. Safety at a time depends counterfactually on what would likely happen at that time or soon after in a way that knowledge does not. I close by considering one objection concerning higher-order safety. (shrink)

In this paper I develop a version of contextualism that I call interests contextualism. Interests contextualism is the view that the truth-conditions of knowledge ascribing and denying sentences are partly determined by the ascriber’s interests and purposes. It therefore stands in opposition to the usual view on which the truth-conditions are partly determined by the ascriber’s conversational context. I give an argument against one particular implementation of the usual view, differentiate interests contextualism from other prominent versions of contextualism and argue (...) that, unlike those versions, interests contextualism can mitigate against the epistemic descent objection put forward by Duncan Pritchard in his ‘Contextualism, Scepticism, and the Problem of Epistemic Descent’ (the objection is that, on the contextualist view, an ascriber of knowledge cannot, for some subject S and proposition p, properly ascribe knowledge that p to S if that ascriber has previously retracted an earlier ascription of knowledge that p to S). (shrink)

The claim of this paper is that the everyday functions of knowledge make most sense if we see knowledge as contrastive. That is, we can best understand how the concept does what it does by thinking in terms of a relation “a knows that p rather than q.” There is always a contrast with an alternative. Contrastive interpretations of knowledge, and objections to them, have become fairly common in recent philosophy. The version defended here is fairly mild in that there (...) is no suggestion that we cannot think in terms of a simpler not explicitly contrastive relation “a knows that p.” Some, for instance Schaffer (2005) and Karjalainen and Morton (2003), have hinted that this stronger possibility may be right. But all that I am arguing now is that facts that are easily expressed in contrastive terms are vital to understanding why we need the concept of knowledge. In a piece that is in some ways a companion to this one ("Contrastivism" in Duncan Pritchard and Sven Bernecker, eds. The Routledge Companion to Epistemology. Routledge 2010, 513-522), I give a general survey of theories of contrastive knowledge and the differences between them. (shrink)

This monograph contributes to the scientific misconduct debate from an oblique perspective, by analysing seven novels devoted to this issue, namely: Arrowsmith by Sinclair Lewis (1925), The affair by C.P. Snow (1960), Cantor’s Dilemma by Carl Djerassi (1989), Perlmann’s Silence by Pascal Mercier (1995), Intuition by Allegra Goodman (2006), Solar by Ian McEwan (2010) and Derailment by Diederik Stapel (2012). Scientific misconduct, i.e. fabrication, falsification, plagiarism, but also other questionable research practices, have become a focus of concern for academic (...) communities worldwide, but also for managers, funders and publishers of research. The aforementioned novels offer intriguing windows into integrity challenges emerging in contemporary research practices. They are analysed from a continental philosophical perspective, providing a stage where various voices, positions and modes of discourse are mutually exposed to one another, so that they critically address and question one another. They force us to start from the admission that we do not really know what misconduct is. Subsequently, by providing case histories of misconduct, they address integrity challenges not only in terms of individual deviance but also in terms of systemic crisis, due to current transformations in the ways in which knowledge is produced. Rather than functioning as moral vignettes, the author argues that misconduct novels challenge us to reconsider some of the basic conceptual building blocks of integrity discourse. (shrink)

Sensitivity and safety are modal concepts of knowledge. A person’s belief that p is sensitive if and only if in the closest possible world where p is false S does not believe that p. A person’s belief that p is safe if and only if in most near-by possible worlds in which S continues to form her belief that p in the same way as in the actual world the belief continues to be true. Robert Nozick claims that sensitivity is (...) a necessary condition for knowledge. Ernest Sosa, Timothy Williamson and Duncan Pritchard argue among others that safety is necessary for knowledge. I shall contest both views by offering counterexamples of persons, to whom it is highly plausible to ascribe knowledge although their beliefs are neither sensitive nor safe. I conclude that neither sensitivity nor safety is a necessary condition for knowledge and that insensitive and unsafe knowledge exists. (shrink)

I argue that we should question the orthodox way of thinking about epistemological disjunctivism. I suggest that we can formulate epistemological disjunctivism in terms of states of seeing things as opposed to states of seeing that p. Not only does this alternative formulation capture the core aspects of epistemological disjunctivism as standardly formulated, it has two salient advantages. First, it avoids a crucial problem that arises for a standard formulation of epistemological disjunctivism—the basis problem. And second, it is less committed (...) than standard formulations are in the metaphysics of perception. (shrink)

This chapter both explains the origins of emotivism in C. K. Ogden and I. A. Richards, R. B. Braithwaite, Austin Duncan-Jones, A. J. Ayer and Charles Stevenson (along with the endorsement by Frank P. Ramsey, and the summary of C. D. Broad), and looks at MacIntyre's criticisms of emotivism as the inevitable result of Moore's attack on naturalistic ethics and his ushering in the fact/value, which was a historical product of the Enlightenment.

In this paper, I respond to an objection raised by Duncan Pritchard and Jesper Kallestrup against virtue epistemology. In particular, they argue that the virtue epistemologist must either deny that S knows that p only if S believes that p because of S’s virtuous operation or deny that intuitive cases of testimonial knowledge. Their dilemma has roots in the apparent ease by which we obtain testimonial knowledge and, thus, how the virtue epistemologist can explain such knowledge in a way (...) that both preserves testimonial knowledge and grounds it in one’s virtues. I argue that the virtue epistemologist has a way to accomplish both tasks if we take epistemic trust to be an intellectual virtue. I briefly discuss what such trust must look like and then apply it to the dilemma at hand: showing that a key intellectual virtue plausibly operates in cases of testimonial knowledge and/or belief. (shrink)

Epistemological disjunctivism says that one can know that p on the rational basis of one’s seeing that p. The basis problem for disjunctivism says that that can’t be since seeing that p entails knowing that p on account of simply being the way in which one knows that p. In defense of their view disjunctivists have rejected the idea that seeing that p is just a way of knowing that p (the SwK thesis). That manoeuvre is familiar. In this paper (...) I explore the prospects for rejecting instead the thought that if the SwK thesis is true then seeing that p can’t be one’s rational basis for perceptual knowledge. I explore two strategies. The first situates disjunctivism within the context of a ‘knowledge-first’ approach that seeks to reverse the traditional understanding of the relationship between perceptual knowledge and justification (or rational support). But I argue that a more interesting strategy situates disjunctivism within a context that accepts a more nuanced understanding of perceptual beliefs. The proposal that I introduce reimagines disjunctivism in light of a bifurcated conception of perceptual knowledge that would see it cleaved along two dimensions. On the picture that results perceptual knowledge at the judgemental level is rationally supported by perceptual knowledge at the merely functional or ‘animal’ level. This supports a form of disjunctivism that I think is currently off the radar: one that’s consistent both with the SwK thesis and a commitment to a traditional reductive account of perceptual knowledge. (shrink)

This paper explores religious belief in connection with epistemological disjunctivism. It applies recent advances in epistemological disjunctivism to the religious case for displaying an attractive model of specifically Christian religious belief. What results is a heretofore unoccupied position in religious epistemology—a view I call ‘religious epistemological disjunctivism’. My general argument is that RED furnishes superior explanations for the sort of ‘grasp of the truth’ which should undergird ‘matured Christian conviction’ of religious propositions. To this end I first display the more (...) familiar perceptual epistemological disjunctivism, contrasting it with both externalist and classically internalist views. This prepares the way for introducing RED with its own distinctive factive mental state operator—pneuming that p. In this second section I present the RED model, not failing to address a potential problem concerning religious disagreement. I also clarify RED’s distinctive internalist aspect, describing how it comports with contemporary internalist thinking in epistemology. I then move in section three to criticize externalist and classical internalist views, showing where they fail to make proper sense of the sort of knowing which should ground mature Christian conviction. Specifically, I highlight three intuitions which I think any theory of religious belief should capture: what I call the case-closed intuition, the good believer intuition, and the Plantingian platitude. This is all to set up for the final section where I argue that RED is superior for understanding proper religious believing—capturing the aforementioned intuitions. (shrink)

Open theists deny that God knows future contingents. Most open theists justify this denial by adopting the position that there are no future contingent truths to be known. In this paper we examine some of the arguments put forward for this position in two recent articles in this journal, one by Dale Tuggy and one by Alan Rhoda, Gregory Boyd, and Thomas Belt. The arguments concern time, modality, and the semantics of ‘will’ statements. We explain why we find none of (...) these arguments persuasive. This wide road leads only to destruction. (shrink)

PRINCÍPIOS DA DIGESTÃO DOS ALIMENTOS NOS BEZERROS -/- -/- E. I. C. da Silva -/- Departamento de Agropecuária – IFPE Campus Belo Jardim -/- Departamento de Zootecnia – UFRPE sede -/- -/- PRINCÍPIOS DA DIGESTÃO DOS ALIMENTOS NOS BEZERROS -/- -/- INTRODUÇÃO -/- Se todos os bezerros pudessem ser criados por suas mães, haveria pouca necessidade de inúmeros livros, artigos e trabalhos, como esse, sobre a criação e o manejo básico desses animais. A maioria das vacas desempenha um ótimo papel (...) na criação dos seus descendentes, desde que sejam tomados os devidos cuidados com relação a alimentação, saúde e a outros aspectos relativos à criação desses neonatos. A essência da pecuária bovina relativa à criação de bezerros é manter esses animais vivos e aptos o suficiente para desempenhar atividades produtivas de grande importância na propriedade. Para tanto, os criadores necessitam entender o desenvolvimento do trato digestivo do bezerro e os conceitos básicos da digestão dos alimentos por ele, e é isso que pretendo aclarar de forma clara e concisa com esse trabalho. -/- -/- 1.1 O TRATO DIGESTIVO DO BEZERRO -/- Um animal adulto necessita de quatro estômagos funcionais para dar-lhe a capacidade de utilizar a ampla gama de alimentos disponíveis. -/- O retículo e o rúmen abrigam milhões de micróbios que fermentam e digerem o material vegetal, em especial às presentes nas forragens. O omaso permite a absorção de água do conteúdo do intestino. O abomaso, ou quarto estômago, é o verdadeiro estômago, comparável ao dos humanos, e permite a digestão ácida dos alimentos. -/- O bezerro muito jovem não desenvolve a capacidade de digerir o pasto, sendo assim o abomaso é o único estômago funcional ao nascer. Tanto os animais recém-nascidos como os adultos têm um intestino delgado funcional que permite a digestão alcalina dos alimentos. -/- A figura 1 ilustra a anatomia dos estômagos e intestino delgado de um bezerro recém-nascido. Esse diagrama esquemático mostra as dimensões relativas dos quatro estômagos, o sulco esofágico, que vai do esôfago até o abomaso, e o esfíncter pilórico ou válvula no fundo do abomaso, que controla a velocidade de movimento do conteúdo do intestino no duodeno. -/- O omaso e o abomaso representam cerca de 70% da capacidade total do estômago no bezerro recém-nascido. Por outro lado, nas vacas adultas, eles compõem apenas 30% da capacidade total do estômago (figura 2). -/- A digestão dos alimentos é auxiliada pela secreção de certos produtos químicos denominados enzimas, que estão presentes nas várias partes do intestino. Por exemplo, os bezerros produzem a enzima renina na parede do abomasal para auxiliar na digestão das proteínas do leite, enquanto a lactase é produzida na parede do duodeno para a digestão do açúcar do leite (lactose). Estas enzimas operam mais eficazmente em diferentes níveis de acidez no conteúdo do intestino, ácido no abomaso e alcalino no duodeno. Para conseguir isso, o bezerro segrega eletrólitos, ou sais minerais, com as enzimas, para mudar o conteúdo do intestino de um tipo para outro. -/- Os produtos finais da digestão dos diferentes componentes dos alimentos são absorvidos através da parede do intestino, mediante as vilosidades intestinais, para a corrente sanguínea, onde são levados para as diferentes partes do corpo para o crescimento e desenvolvimento do animal. -/- -/- 1.2 O BEZERRO ALIMENTADO COM LEITE -/- O Leite ou substituto do leite, quer seja apreendido através de uma teta ou bebido de um balde, é canalizado do esôfago através do sulco esofágico para o abomaso. Este sulco é um pequeno canal na parede do rúmen que é controlado por músculos que permitem que os líquidos sejam diretamente enviados para o abomaso e que não entrem no rúmen. O sulco é ativado em resposta a diferentes estímulos. Funciona bem quando os bezerros amamentam-se através das tetas das mães, mas às vezes não funciona quando bebem de um balde. Essa parece ser uma condição psicológica em resposta aos bezerros separados de suas mães. A maioria dos bezerros podem ser treinados pelo tratador para beber o leite do balde rapidamente e bem, a metodologia empregada é a da persuasão do animal, ao qual o mesmo possa responder positivamente à nova rotina diária e à mãe substituta na forma do criador do bezerro. Quando o leite ou o substituto do leite entra no abomaso, forma um coágulo firme dentro de alguns minutos sob a influência das enzimas renina e pepsina. Este é o mesmo processo envolvido na fabricação de queijo ou junket, usando renina para coagular a proteína do leite. A coagulação do leite retarda a taxa em que flui para fora do abomaso, permitindo assim uma liberação constante de nutrientes alimentares em todo o intestino e, eventualmente, para a corrente sanguínea. Pode levar de 12 a 18 horas para que a coalhada de leite seja totalmente digerida. -/- As enzimas que atuam nas proteínas do leite requerem um ambiente ácido e esse é fornecido pela secreção do ácido clorídrico no abomaso. No entanto, até que a digestão ácida esteja operando de forma eficiente, e isso pode levar até sete dias, a única forma de proteína que pode ser digerida é a caseína. Não há substituto para a caseína no bezerro muito jovem. Os substitutos do leite que contêm outras formas de proteína não podem ser devidamente digeridos até que os bezerros sejam mais velhos. Logo, é necessário muito cuidado para não fornecer substitutos ou sucedâneos que contenham fontes proteicas que não possam ser digeridas pelo estômago do animal, para que não ocasione complicações gastrintestinais. -/- A digestão do leite pode ser melhorada com a inclusão de coalho, que pode ser obtido a partir de fábricas de queijo ou aditivos comerciais de leite de bezerro para a primeira semana ou mais. Esses produtos comerciais podem fornecer ácidos adicionais para reduzir o pH abomasal e incrementar a quantidade de enzimas e bactérias específicas para aumentar a taxa de degradação da coalhada de leite. Tais aditivos são chamados probióticos, na medida em que ajudam nos processos digestivos normais. A pesquisa nem sempre os encontrou para melhorar o desempenho e a saúde dos bezerros, e eles são mais propensos a ser benéficos quando os bezerros estão sofrendo de problemas de saúde. Além disso, a sua eficácia, em termos de custo-benefício é, por vezes, questionada. -/- Qualquer leite de uma alimentação anterior está envolvido neste coágulo recém-formado. As proteínas líquidas de soro de leite e a lactose são rapidamente separadas da coalhada de leite e passam para o abomaso. A gordura do leite contida na coalhada de leite é decomposta por outra enzima, a lipase. Esta é secretado na boca pela saliva e incorporada quando o leite é engolido. A alimentação pelas tetas em vez da alimentação através do balde parece produzir mais saliva e, portanto, mais lipase. A digestão adicional da proteína do leite e da gordura ocorre no duodeno com a ajuda das enzimas produzidas no pâncreas. -/- A lactose, que é rapidamente liberada da coalhada de leite no abomaso, é dividida em glicose e galactose e estas são absorvidas na corrente sanguínea para formar a principal fonte de energia para os bezerros jovens. -/- As gorduras são divididas em ácidos graxos e glicerol para absorção e uso como energia, enquanto as proteínas são divididas em aminoácidos e peptídeos para absorção e uso como fontes de proteína corporal. -/- O amido de cereais, por exemplo, é uma importante fonte de energia em bezerros mais velhos, mas esses animais, nas suas primeiras semanas de vida, não conseguem digerir o amido. -/- O abomaso não é ácido até que o bezerro tenha 1-2 dias de idade e isso apresenta vantagens e desvantagens. A principal vantagem é que as proteínas imunes no colostro não podem ser digeridas nesse compartimento estomacal, por isso são absorvidas na corrente sanguínea na mesma forma quando produzidas pela vaca. Isso garante o seu papel como anticorpos para proteger contra as doenças e infecções. A baixa acidez do conteúdo abomasal no bezerro recém-nascido constitui um risco potencial das bactérias (e provavelmente vírus) tomadas através da boca. Estes não serão mortos pela digestão ácida, sendo assim podem passar para os intestinos, onde podem fazer mal ao bezerro recém-nascido. -/- Todos os bezerros pegam bactérias nos primeiros dias de vida e isso é essencial para o desenvolvimento normal do rúmen (flora microbiana). No entanto, a primeira bactéria a colonizar o intestino também pode causar danos. Desde que o bezerro tenha bebido colostro, os anticorpos maternos podem controlar a propagação dessas bactérias mais nocivas. -/- O bezerro alimentado com leite deve, então, produzir uma digestão ácida no abomaso e uma digestão alcalina no duodeno. Isto é conseguido pela produção de eletrólitos na parede do intestino. -/- Bezerros que sofrem de escoriações devido a distúrbios nutricionais ou infecções bacterianas podem perder grandes quantidades de água e eletrólitos em suas fezes. Estes devem ser reabastecidos como parte do tratamento para as escoriações. -/- O colostro é o primeiro leite produzido por vacas recém-paridas. Além de fornecer nutrientes essenciais para a alimentação animal, fornece anticorpos maternos que permitem a transferência passiva de imunidade contra doenças. As recomendações para a alimentação com colostro serão abordadas brevemente em outro trabalho. -/- -/- 1.3 DESENVOLVIMENTO DO RÚMEN E O PROCESSO DE DESMAME -/- Quando os bezerros são desmamados, o custo da criação diminui acentuadamente. Os custos de alimentação são mais baixos, os insumos de trabalho são reduzidos e a incidência de problemas de saúde é menor. No sentido econômico, faz sentido desmamar os bezerros assim que for razoável. No entanto, o bezerro é forçado a sofrer várias mudanças dramáticas, a saber: -/-  A fonte primária de nutrientes muda de líquido para sólido. -/-  A quantidade de matéria seca que o bezerro recebe é reduzida. -/-  O bezerro deve adaptar-se de um tipo monogástrico a um ruminante de digestão, que inclui a fermentação de alimentos. -/-  Mudanças na habitação e no manejo muitas vezes ocorrem em torno do desmame, o que pode aumentar o estresse. -/- Ao nascer, o rúmen é uma parte pequena e estéril do intestino que, ao desmame deve se tornar o compartimento mais importante dos quatro estômagos. Deve aumentar em tamanho, atividade metabólica interna e fluxo sanguíneo externo. Os cinco requisitos para o desenvolvimento ruminal são: -/-  Estabelecimento de bactérias. -/-  Líquido. -/-  Saída de material (ação muscular). -/-  Capacidade absortiva do tecido. -/-  Substrato para permitir o crescimento bacteriano, tais como minerais reciclados, bem como nutrientes para alimentação. -/- Antes do consumo de alimentos sólidos, as bactérias existentes fermentam o cabelo ingerido, o estrato e o leite que flui do abomaso para o rúmen. A maior parte da água que entra no rúmen provém da água livre (água real não contida no leite ou na solução substituta do leite). O leite contornará o rúmen através do sulco esofágico, enquanto a água livre não. -/- O rúmen se desenvolve a partir de um órgão muito pequeno em bezerros recém-nascidos (1-2 L) para a parte mais importante do intestino (25-30 L) por 3 meses de idade. Ele pode aumentar muito rapidamente durante as primeiras semanas de vida, dado o manejo da alimentação direita. -/- O crescimento do rúmen ocorre apenas sob a influência dos produtos finais da digestão no mesmo, que resultam da fermentação de alimentos sólidos pelos micróbios presentes nesse compartimento. O desenvolvimento ocorre em grande parte através do crescimento das papilas ruminais (figura 5 e 6) na parede ruminal (estruturas semelhantes a folhas na superfície interna), que aumentam a área superficial do rúmen e, portanto, a sua capacidade de absorver estes produtos finais de digestão. Portanto, os concentrados favorecem melhor o desenvolvimento dessas papilas ruminais. Para tanto, é necessário, com um tempo, ir incrementando a dieta sólida gradativamente para que esses animais deixem de consumir o leite das vacas produtoras e possam alimentar-se de ração e pastagens, que é a finalidade da criação de bovinos, ou seja, criar animais com menor custo possível e engordá-los através de ração, mas principalmente de pastagens. -/- A capacidade do rúmen e a ingestão de alimentos sólidos estão intimamente relacionadas. O desenvolvimento do rúmen é muito lento em bezerros alimentados com grandes quantidades de leite. O leite satisfaz seus apetites para que eles não tenham fome suficiente para comer qualquer alimento sólido. Logo, é necessário diminuir paulatinamente o fornecedor do leite para esses animais, favorecendo a ingestão de alimentos sólidos e desenvolvendo o rúmen, estômago que digere as fibras das forragens e que os tona animais peculiares. -/- A ruminação pode ocorrer com cerca de 2 semanas de idade e é uma boa indicação de que o rúmen está se desenvolvendo. Alimentos sólidos, bem como a ruminação, estimulam a produção de saliva e isso fornece nutrientes como ureia e bicarbonato de sódio para produzir os substratos para o crescimento e desenvolvimento da flora bacteriana. -/- No desmame precoce, é importante limitar a quantidade de leite oferecida e a sua disponibilidade durante todo o dia. Também é essencial fornecer alimentos sólidos. Os grosseiros (de baixa ou alta qualidade) devem ser oferecidos em combinação com concentrados de alta qualidade. -/- O criador deve tomar cuidado com o fornecimento de alimentos como a ração farelada, uma vez que essa ração pode entrar pelas vias nasais e ocasionar complicações respiratórias; há alguns relatos de bezerros mortos após a ingestão de ração farelada, na autópsia de um dos casos foi diagnosticada uma morte por esses grãos farelados presentes no pulmão. Portanto, para evitar complicações o ideal é que se forneça uma ração denominada peletizada. -/- Os alimentos grosseiros (volumosos) estimulam o desenvolvimento do rúmen, enquanto os concentrados fornecem nutrientes para a alimentação animal que não são fornecidos pelas quantidades limitadas de leite oferecidas. Sem os concentrados, o crescimento dos bezerros é lento, mas o rúmen ainda se desenvolve, resultando em animais barrigudos. -/- A ureia fornece nitrogênio para os micróbios, enquanto o bicarbonato de sódio atua como um tampão ruminal, ajudando a manter um pH estável no conteúdo do rúmen. Isso é, particularmente, importante quando os bezerros comem grandes quantidades de grãos de cereais na vida adulta, pois os micróbios do rúmen podem produzir muito ácido lático durante a fermentação desse material. -/- Envenenamento por grãos ou acidose ocorre quando os níveis de ácido lático são excessivamente elevados e tornam-se tóxicos para os micróbios do rúmen e, eventualmente, para o animal. Assim como os produtos finais que são absorvidos através da parede do rúmen, a fermentação microbiana produz os gases dióxido de carbono e metano e estes são normalmente exalados. Quando algo impede a fuga destes gases do rúmen, o inchaço pode se manifestar em qualquer fase da vida, diz-se do animal estufado. -/- -/- 1.4 O PAPEL DA FORRAGEM NO PROCESSO DE DESMAME -/- Existem inúmeras controvérsias acerca do papel da forragem no processo de desmame. Pesquisas realizadas na década de 1980 indicaram claramente que a forragem era benéfica, enquanto pesquisas da década de 1990 descobriram que nem sempre era necessário o fornecimento da forragem para que os bezerros fossem desmamados e que não sofresse estresse e nem apresentasse baixa eficiência produtiva e reprodutiva no futuro. Na maioria das pesquisas anteriores, os bezerros eram desmamados com a oferta de concentrados moídos como pellets com ou sem a presença de feno longo ou palha. Porém, a inclusão de forragens na dieta melhorou a ingestão e o desempenho, além de permitir o desmame precoce. -/- Na pesquisa posterior, os bezerros geralmente alimentavam-se de concentrados grosseiramente moídos, além de alguns volumosos, enquanto alguns até incluíam volumosos picados finos na mistura (às vezes chamados de mistura muesli por apresentar o capim e a ração). Nesses estudos, verificou-se que a inclusão de feno ou palha adicional teve pouco efeito no desempenho pré-desmame. -/- Os sistemas de criação de bezerros australianos frequentemente diferem dos demais, especialmente em áreas de parto sazonais. Um número excessivo elevado de bezerros precisam ser criados de uma só vez para lhes fornecer, a todos, currais individuais durante todo o seu período de amamentação. Consequentemente, os bezerros são criados em grupos. Além disso, os ingredientes da maioria dos concentrados para esses animais são finamente moídos. Nessas situações, descobriu-se que a palha limpa é um alimento útil e que deve ser incluso no período pré-desmame. Alguns agricultores preferem feno de boa qualidade, porém estes agricultores geralmente têm bezerros em grupos muito pequenos, muitas vezes um ou dois, por isso possuem maior controle sobre a ingestão de forragem. -/- Figura 7: A alimentação volumosa de bezerros alimentados com leite é uma questão controversa. Imagem cedida pelo IPA -/- É difícil e, portanto, mais caro que os produtores de rações incorporem feno picado nas refeições dos bezerros. Os pellets são muito mais fáceis, pois eles vão fluir para silos. Por fim, os produtores de leite devem incluir o componente volumoso no regime alimentar pré-desmame. A pastagem não é a fonte ideal de forragem volumosa para os bezerros alimentados com leite, uma vez que possui muito pouca fibra e uma baixa densidade de energia alimentar. O seu elevado teor de água limita a sua capacidade de fornecer energia alimentar adequada aos animais em crescimento. Para ingerir a pastagem a capacidade ruminal deveria ser maior, bezerros jovens simplesmente não conseguem comer pasto suficiente, a menos que seja de alta em qualidade. -/- Os bezerros criados com leite e fornecimento gradual de concentrados apresentam uma boa função ruminal às 3 semanas de vida, além de possuírem uma suficiente capacidade ruminal para o desmame entre às 4-6 semanas de idade. No entanto, se a dieta for baseada em leite restrito e pastagem de alta qualidade, a capacidade do rúmen pode não ser suficiente para o desmame até às 8-10 semanas de vida. Mesmo assim, as taxas de crescimento seriam menores em bezerros desmamados com base alimentar somente à pasto, uma vez que a ingestão de energia é insuficiente devido às limitações físicas da capacidade ruminal. -/- Se a qualidade for muito boa e produza apetite, os bezerros preferem volumosos ao invés do concentrado, o que leva a uma ingestão reduzida de nutrientes durante alimentação, tendo como efeito um crescimento mais lento. Quando volumosos e concentrados fornecem apetite no animal, juntamente com o leite limitado, os bezerros podem comer cerca de 10% de palha e 90% de concentrados. Sem o volumoso e a ruminação resultante, o desenvolvimento do rúmen será mais lento devido à falta de saliva e produtos finais da digestão de fibras presentes na parede celular das forragens. -/- -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- -/- BEN ASHER, Aharon. Manual de cría de becerras. Zaragoza: Acribia, 1999. -/- BITTAR, Carla Maris Machado; PORTAL, Rafaela Nunes Sanchez; PEREIRA, Anna Carolina Fett da Cunha. Criação de bezerras leiteiras. Piracicaba: EDUSP, 2018. -/- BLUM, J. W. Nutritional physiology of neonatal calves. Journal of animal physiology and animal nutrition, v. 90, n. 1‐2, p. 1-11, 2006. -/- CAMPOS, OF de. Criação de bezerros até a desmama. Coronel Pacheco: EMBRAPA/CNPGL, 1985. -/- COELHO, S. G. Criação de bezerros. II Simpósio Mineiro de Buiatria, Anais., Belo Horizonte, 2005. -/- DAVIS, Carl L. et al. The development, nutrition, and management of the young calf. Iowa State University Press, 1998. -/- DE OLIVEIRA, Juliana Silva; DE MOURA ZANINE, Anderson; SANTOS, Edson Mauro. Fisiologia, manejo e alimentação de bezerros de corte. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, v. 10, n. 1, 2007. -/- DRACKLEY, James K. Calf nutrition from birth to breeding. Veterinary Clinics of North America: Food Animal Practice, v. 24, n. 1, p. 55-86, 2008. -/- FERREIRA, Lucas Silveira et al. Desempenho animal e desenvolvimento do rúmen de bezerros leiteiros aleitados com leite integral ou sucedâneo. Boletim de Indústria Animal, v. 65, n. 4, p. 337-345, 2008. -/- GUILLOTEAU, P.; ZABIELSKI, R.; BLUM, J. W. Gastrointestinal tract and digestion in the young ruminant: ontogenesis, adaptations, consequences and manipulations. J Physiol Pharmacol, v. 60, n. Suppl 1, p. 37-46, 2009. -/- HUBER, J. T. Development of the digestive and metabolic apparatus of the calf. Journal of Dairy Science, v. 52, n. 8, p. 1303-1315, 1969. -/- LONGENBACH, J. I.; HEINRICHS, Arlyn Judson. A review of the importance and physiological role of curd formation in the abomasum of young calves. Animal feed science and technology, v. 73, n. 1-2, p. 85-97, 1998. -/- LOPES, Marcos Aurélio; VIEIRA, P. de F. Criação de bezerros leiteiros. Jaboticabal: Funep, 1998. -/- LUCCI, Carlos de Sousa. Bovinos leiteiros jovens: nutrição, manejo, doenças. São Paulo: Nobel, 1989. -/- ROY, James Henry Barstow et al. The calf. Boston: Butterworths., 1980. -/- SAVAGE, E. S.; MCCAY, C. M. The nutrition of calves; A review. Journal of Dairy Science, v. 25, n. 7, p. 595-650, 1942. -/- THIVEND, P.; TOULLEC, R.; GUILLOTEAU, P. Digestive adaptation in the preruminant. In: Digestive physiology and metabolism in ruminants. Springer, Dordrecht, 1980. p. 561-585. (shrink)

Comentaba en el Prólogo a la 1ª edición que nos cuesta distinguir las técnicas de los métodos y aceptar que la buena investigación clínica es la que se realiza con método riguroso. Este método reposa en cuatro pilares: que la pregunta o cuestión formulada sea relevante, que esté enunciada de manera precisa y operativa, que sea abordada o respondida con el mejor medio disponible en cada circunstancia, y que evite redundancias o repeticiones de cuestiones que ya han sido examinadas por (...) otros investigadores. Añadía que es imprescindible una dosis de curiosidad y de entusiasmo por lo que se examina. Como se ha dicho con frecuencia, el ensayo clínico es, entre los métodos de investigación clínica, el "patrón oro", el que, gracias a su característica inherente (la distribución aleatoria), está sujeto a menores posibilidades de sesgos. Esta consideración no ha cambiado. Sin embargo, mayor validez interna del método no implica mayor relevancia de los resultados obtenidos. Actualmente es común examinar protocolos de ensayos clínicos bien diseñados, cuyo "único" problema es que pretenden evaluar aspectos de escaso interés farmacológico, terapéutico, epidemiológico o sanitario. ¿Qué interés tiene la evaluación del quinto fármaco de una serie en una indicación para la que ya hay cuatro análogos que le han precedido en su desarrollo? ¿Qué interés tiene la evaluación de un nuevo hipocolesterolemiante o de un nuevo fármaco para la osteoporosis si no se conocen, respectivamente, el impacto de la hipercolesterolemia como factor de riesgo de cardiopatía isquémica o la epidemiología de las fracturas en mujeres postmenopáusicas en nuestro medio? En relación con estos ejemplos, tendría mucho más interés conocer los determinantes epidemiológicos y la historia natural de la cardiopatía isquémica en nuestro medio y conocer la epidemiología de las fracturas "espontáneas" y su impacto sobre la demanda asistencial; para ello serían de mucha utilidad métodos de investigación cuya validez intrínseca podría ser considerada "subóptima" en comparación con el ensayo clínico. En los últimos años ha irrumpido con fuerza en numerosísimas publicaciones el concepto de la "medicina basada en pruebas". Esta moda refleja en parte la importancia que de manera creciente reguladores e industria farmacéutica han concedido a los ensayos clínicos: se ha alcanzado un consenso global sobre la necesidad de demostrar la "eficacia" de los nuevos medicamentos por medio de ensayos clínicos controlados. De este modo, los organismos reguladores y autoridades sanitarias exigen ensayos clínicos como uno de los elementos necesarios para obtener el registro de un nuevo medicamento. Como consecuencia, se realizan y publican muchos más ensayos clínicos que antaño, y actualmente se pueden encontrar ensayos que sustentan la eficacia de la mayoría de los medicamentos disponibles en indicaciones específicas. Si hace unos años bastaba con examinar si había ensayos clínicos que demostraran la eficacia de un determinado medicamento antes de adoptarlo como uno de los de uso común (o de incluirlo en el formulario de un hospital), en la actualidad estas decisiones son más complejas, y se basan sobre todo en una consideración atenta de los objetivos, los métodos y los resultados de cada ensayo o de otros estudios destinados a evaluar eficacia, seguridad, conveniencia o comodidad y coste. Un buen clínico debe saber a la vez leer críticamente las publicaciones científicas y producir información relevante. Leer críticamente significa evaluar la pertinencia de los problemas investigados, los métodos aplicados y la interpretación de los resultados obtenidos. Producir información relevante implica saber identificar los problemas que deben y pueden ser objeto de investigación, formularlos, y ser protagonista (generalmente como parte de un equipo) de la elaboración del plan de investigación. En los últimos años se han publicado varios textos similares al que tiene en sus manos, todos ellos de gran calidad. El presente no pretende ser el más exhaustivo, sino sobre todo interesar a los profesionales sanitarios en el apasionante campo de la investigación clínica, en su sentido más amplio, estimulando la autonomía del lector para investigar un problema o una situación, y para aprender a leer las publicaciones científicas clínicas. Su lectura debe contribuir a que términos como "doble ciego", "p<0,05", "casos y controles", etc. dejen de ser fetiches-misterios, para convertirse en herramientas conceptualmente sencillas, útiles para la evaluación de la actividad asistencial. Esta nueva edición está muy ampliada respecto a la anterior. Se han reorganizado las generalidades sobre los objetivos y métodos de la investigación clínica, se han ampliado algunos aspectos del ensayo clínico, como el análisis de subgrupos, los aspectos estadísticos y éticos y las publicaciones sobre ensayos clínicos, se han añadido cuatro nuevos capítulos, sobre efectividad y eficacia, metaanálisis, ensayos en un solo paciente y farmacoeconomía, y el Glosario ha sido revisado y ampliado (sobre todo con términos de farmacocinética, desarrollo preclínico de fármacos, estadística y biotecnología genética), e incluye casi 750 términos. Para su elaboración me he basado en numerosos textos y diccionarios,a aunque he reformulado la mayoría de las definiciones y he optado por añadir en ocasiones algún comentario personal a muchas de ellas. Carles Vallvé ha escrito el capítulo sobre Normas de Buena Práctica Clínica. Agradezco asimismo las precisones y comentarios de Eulalia Dalmau, Javier Jiménez, Josep Maria Castel y Xavier Vidal, así como los comentarios a versiones anteriores de Fernando Antezana y Jorleny Rojas. Eduard Diogène me sugirió la idea de la portada, El sueño de la razón produce monstruos, que Goya comentaba así: " La fantasía abandonada de la razón produce monstruos imposibles: unida con ella es madre de las artes y origen de sus marabillas" La 1ª edición de este libro, que fue promovida por Zeneca, tuvo una amplia difusión, en España y en América Latina. AstraZeneca me propuso preparar esta 2ª edición del mismo modo abierto que en ocasión de la primera; su actual Director Médico Ramón Estiarte me ha ayudado en la selección de términos para el Glosario. A él y al anterior Director Médico de Zeneca, Manuel Martín, agradezco su idea inicial, su estímulo y ayuda, y las facilidades que han dado para la difusión de este libro. Joan-Ramon Laporte. (shrink)

The subject of the article is a mass psychology of B.P. Vysheslavtsev. This is a socio-philosophical conception, which created by Vysheslavtsev through the synthesizing of German classical philosophy, neo-Kantianism, Russian religious philosophy and analytical psychology. He developed the mass psychology in close collaboration with C.G. Jung by his direct order. The mass psychology, despite the heterogeneity of its foundations, became an organic continuation of analytical psychology. Moreover, there is reason to suppose that Vysheslavtsev's socio-philosophical and religious ideas influenced all of (...) Jung’s later work. The main method used was a comparative analysis of the ideas of Vysheslavtsev and Jung, as well as a critical interpretation of the original sources, including unpublished archival materials — letters and manuscripts. The novelty lies in the fact that previously the mass psychology of Vysheslavtsev eluded the attention of researchers. This is primarily due to the inaccessibility of sources on this issue, since some of them are either not published and stored in archives, including the Bakhmeteff Archive (Columbia University in the City of New York) and C.G. Jung Papers Collection (ETH Zurich University Archive), or was published in rare foreign journals and not translated into Russian. At the same time, without these sources it is difficult to understand not only the evolution of Vysheslavtsev’s views, but also the logic and reasons for the development of Jung’s ideas from the 1940s to his death. Thus, this article is intended to partially replenish these gaps in the history of Russian and European philosophy and psychology. Предметом исследования данной статьи является созданная на основе синтеза немецкой классической философии, неокантианства, русской религиозной философии и аналитической психологии социально-философская концепция Б.П. Вышеславцева, названная им "массовая психология". Данная концепция разрабатывалась в тесном взаимодействии с К.Г. Юнгом, в том числе, по его непосредственному заказу. Массовая психология Вышеславцева, несмотря на разнородность её основ, стала органичным продолжением аналитической психологии. Более того, есть основания полагать, что социально-философские и религиозные идеи Вышеславцева оказали влияние на всё позднее творчество Юнга. В качестве основного метода использовался компаративный анализ идей Вышеславцева и Юнга, а также критическая интерпретация первоисточников, включая неопубликованные архивные материалы - письма и рукописи. Новизна заключается в том, что ранее массовая психология Вышеславцева ускользала от внимания исследователей. Обусловлено это, в первую очередь, труднодоступностью источников по данной проблеме, так как часть из них либо не опубликована и хранится в архивах, в том числе в Бахметьевском архиве Колумбийского университета (Нью-Йорк) и Архиве Юнга (Цюрих), либо была опубликована в редких иностранных изданиях и не переведена на русский язык. Вместе с тем, без данных источников трудно понять не только эволюцию взглядов Вышеславцева, итогом которой стал труд "Кризис индустриальной культуры", но также логику и причины развития представлений Юнга начиная с 1940-х годов и заканчивая его смертью. Тем самым, данная статья призвана отчасти восполнить указанные лакуны в истории русской и европейской философии и психологии. (shrink)

Grey zone attacks tend to paralyze response for two reasons. First, they present us with choice scenarios of inherently dilemmatic structure, e.g., Prisoners’ Dilemmas and games of chicken, complicated by difficult conditions of choice, such as choice under risk or amid vagueness. Second, they exploit our uncertainty about how much we do or should care about the things under attack¬—each attack is small in effect, but their effects accumulate: how should we decide whether to treat a given attack as something (...) meriting a serious response rather than a mere irritation to be ignored? This chapter brings standard decision theoretic tools to bear on the issues, tools such as the maximization of expected utility principle, and the precautionary principle. But it also develops three innovations. It shows that seeing it as possible to make choices not just of actions given our values, but also choices of values themselves, can extricate us from certain kinds of decision paralysis. It shows how we can rationally regard ourselves as having bright decision lines even when nothing in the circumstance of choice has these lines in its structure. And it shows how certain conflict escalation risks from the former two strategies can be managed by both parties seeing that cooperation can yield a sharable surplus of goods, and that cooperation can be rational upon a rationally defensible change in their values so that each comes to derive utility from the success of both parties. This yields cooperative solutions to what amount to Prisoners’ Dilemmas. The Cold War was prosecuted on the logic of strategic rationality and that part of game theory that is deterrence theory. We need a new logic from decision theorists for the games that constitute grey zone conflict. (shrink)

This chapter looks at the discussion of materialism in John Locke’s Essay concerning Human Understanding, and then at parts of the Anglophone reaction to those discussions. It considers the early criticisms of Locke by Edward Stillingfleet and the anonymous author of three sets of Remarks on Locke’s Essay. It then looks at some other ways in which readers reacted to Locke’s discussions: the views of Anthony Collins and John Toland, which one might be tempted to think of as Lockean materialism; (...) William Carroll’s reading of Locke as a Spinozistic materialist; and the dualistic Lockeanism of William Duncan’s Lockean logic textbook. (shrink)

The author presents reasons for thinking that the evil we observe in the world is not even prima facie evidence against the existence of God.

An exploration of RA Duff's 'communicative theory of punishment' in contexts of deep legal and cultural pluralism.

Research on human decision making is at the present time undergoing rapid changes. From previously being much focused on models and approaches with an origin in economy, much of the present day research finds its inspiration from disciplinary approaches concerned with incorporating more of the context that the decision making takes place in. This context includes psychological aspects of the decision maker and social-cultural aspects of the situation he or she acts in. All human decision making occurs in dynamically changing (...) contexts. One factor contributing to this is that human beings or groups in many situations act as entrepreneurs trying to improve the situation for themselves or their organization. Given that this is the case, it is of increasing interest for both researchers and practitioners interested in the social aspects of decision making to consider the relation between creativity and decision making. (shrink)

The language of rights pervades modern social and political discourse and yet there is deep disagreement amongst citizens, politicians and philosophers about just what they mean. Who has them? Who should have them? Who can claim them? What are the grounds upon which they can be claimed? How are they related to other important moral and political values such as community, virtue, autonomy, democracy and social justice? In this book, Duncan Ivison offers a unique and accessible integration of, and (...) introduction to, the history and philosophy of rights. He focuses especially on the politics of rights: the fact that rights have always been, and will remain, deeply contested. He discusses not only the historical contexts in which some of the leading philosophers of rights formed their arguments, but also the moral and logical issues they raise for thinking about the nature of rights more generally. At each step, Ivison also considers various deep criticisms of rights, including those made by communitarian, feminist, Marxist and postmodern critics. The book is aimed at students and readers coming to these issues for the first time, but also at more knowledgeable readers looking for a distinctive integration of history and theory as applied to questions about the nature of rights today. (shrink)

I discuss Hume's views about whether simplicity and generality are positive features of explanations. In criticizing Hobbes and others who base their systems of morality on self interest, Hume diagnoses their errors as resulting from a "love of simplicity". These worries about whether simplicity is a positive feature of explanations emerge in Hume's thinking over time. But Hume does not completely reject the idea that it's good to seek simple explanations. What Hume thinks we need is good judgment about when (...) we are going too far in our search for simple explanations. These worries about simplicity are not unique to Hume. We can see versions of them in the work of Hutcheson, Smith, and Reid. (shrink)

Las organizaciones públicas se comunican con los ciudadanos de diversas formas, y no están ajenas a la utilización de las redes sociales. La investigación tiene como finalidad analizar la comunicación de la Responsabilidad Social de las empresas públicas uruguayas, a través de la red Twitter. Para el análisis de los tweets se emplea la herramienta Burrrd, Twelets y se utiliza, como referencia, la metodología propuesta por Aldeanueva y Arrabal (2018), identificando un diccionario de términos relacionados con responsabilidad social en las (...) publicaciones realizadas, agrupándolos por temáticas comunes, a fin de analizar qué comunican las organizaciones públicas sobre su responsabilidad social. (shrink)

This paper reviews six attempts to give cooperative solutions to Prisoners Dilemmas: symmetry (agents are in identical situations, so should choose the same way, so should both choose cooperation because that’s better for each), mechanism (each agent should delegate the decision to a machine which will choose cooperation for them provided the other does likewise), inducement (the agents should make a side bet which pays off only upon both cooperating), resolution (each agent should resolve to cooperate, then act on the (...) resolution), alternative principle (rationality requires not dominance reasoning and so defecting, but constrained maximization or resolution compliance or “sophisticated” choosing, and so cooperation), and preference revision (each agent should acquire conditional preferences to cooperate, then cooperate provided the other agent has acquired similar preferences). It distinguishes one-stage from two-stage games, as well as endogenously available solutions (ones available to agents in the circumstances of the game merely due to the nature of rationality) from solutions requiring exogenous devices. It contrasts Edward McClennen’s endogenous solution, which is some combination of resolution and alternative principle solution, with David Gauthier’s endogenous alternative principle solution. It argues that all have problems, ones best solved by the endogenous preference revision solution defended by Duncan MacIntosh. (shrink)

The original – and often continuing – sin of countries with a settler colonial past is their brutal treatment of indigenous peoples. This challenging legacy continues to confront modern liberal democracies ranging from the USA and Canada to Australia, New Zealand and beyond. Duncan Ivison’s book considers how these states can justly accommodate indigenous populations today. He shows how indigenous movements have gained prominence in the past decade, driving both domestic and international campaigns for change. He examines how the (...) claims made by these movements challenge liberal conceptions of the state, rights, political community, identity and legitimacy. Interweaving a lucid introduction to the debates with his own original argument, he contends that we need to move beyond complaints about the ‘politics of identity’ and towards a more historically and theoretically nuanced liberalism better suited to our times. This book will be a key resource for students and scholars interested in political theory, historic injustice, Indigenous studies and the history of political thought. (shrink)

The classical theory of probability has long been abandoned and is seen by most philosophers as a non-contender—a mere precursor to newer and better theories. In this paper I argue that this is a mistake. The main reasons for its rejection—all related to the notorious principle of indifference—are that it is circular, of limited applicability, inconsistent, and dependent upon unjustified empirical assumptions. I argue that none of these claims is true and that the classical theory remains to be refuted.

The Ashgate Research Companion to Multiculturalism brings together a collection of new essays by leading and emerging scholars in the humanities and social sciences on some of the key issues facing multiculturalism today. It provides a comprehensive and cutting-edge treatment of this important and hotly contested field, offering scholars and students a clear account of the leading theories and critiques of multiculturalism that have developed over the past twenty-five years, as well as a sense of the challenges facing multiculturalism in (...) the future. Key leading scholars, including James Bohman, Barbara Arneil, Avigail Eisenberg, Ghassan Hage, and Paul Patton, discuss multiculturalism in different cultural and national contexts and across a range of disciplinary approaches. In addition to contributions, Duncan Ivison also provides a comprehensive Introduction which surveys the field and offers an extensive guide to further reading. (shrink)

A powerful argument against the counterfactual comparative account of harm is that it cannot distinguish harming from failing to benefit. In reply to this problem, I suggest a new account of harm. The account is a counterfactual comparative one, but it counts as harms only those events that make a person occupy his level of well-being at the world at which the event occurs. This account distinguishes harming from failing to benefit in a way that accommodates our intuitions about the (...) standard problem cases. In laying the groundwork for this account, I also demonstrate that rival accounts of harm are able to distinguish harming from failing to benefit only if, and because, they also appeal to the distinction between making upshots happen and allowing upshots to happen. One important implication of my discussion is that preserving the moral asymmetry between harming and failing to benefit requires a commitment to the existence of a metaphysical and moral distinction between making and allowing. (shrink)

Postcolonial Liberalism presents a compelling account of the challenges to liberal political theory by claims to cultural and political autonomy and land rights made by indigenous peoples today. It also confronts the sensitive issue of how liberalism has been used to justify and legitimate colonialism. Ivison argues that there is a pressing need to re-shape liberal thought to become more receptive to indigenous aspirations and modes of being. What is distinctive about the book is the middle way it charts between (...) separatism, on the one hand, and assimilation, on the other. These two options present a false dichotomy as to what might constitute a genuinely postcolonial liberal society. In defending this ideal, the book addresses important recent debates over the nature of public reason, justice in multicultural and multinational societies, collective responsibility for the past, and clashes between individual and group rights. (shrink)

There have been two distinctive aspects to James Tully’s approach to the study of imperialism over the years, and both are put to work in these remarkable volumes. The first is his belief in two seemingly contradictory claims: (i) that imperialism is much more pervasive than usually thought (conceptually, historically and practically); and yet (ii) that there are many more forms of resistance to it than usually appreciated. (Part of a symposium in Political Theory on James Tully's 'Public Philosophy in (...) a New Key'). (shrink)

There are two kinds of resentment relevant to the politics of multiculturalism today. 1 The first, which is basically Nietzsche’s conception of ressentiment, occurs under conditions in which people are subject to systematic and structural deprivation of things they want (and need), combined with a sense of powerlessness about being able to do anything about it. It manifests itself in terms of a focused anger or hatred towards that group of people who seem to have everything they want, and yet (...) also symbolize their powerlessness to get it. For Nietzsche, of course, it was out of this set of emotions and psychological state of mind that the ‘slave revolt’ that gave birth to modern morality emerged, supplanting the aristocratic values oriented around good and bad with the reactive and slavish values of those oriented around good and evil (Nietzsche 1989: 36- 39). The desire to lash out or take revenge against those who you perceive as keeping you down, keeping you from enjoying all the benefits and advantages others enjoy and that you want or feel you deserve, for Nietzsche, is a basic emotional orientation that can – in combination with other complex forces - reshape an entire culture. A second form of resentment is of a more moralized kind; a reactive sentiment bound up with holding another morally accountable for their actions. I resent your curtailment of my liberty, for example, just because I believe we share certain moral commitments – for example, a.. (shrink)

In this essay we argue for the Janus-faced nature of hope. We show that attempts to sanitise the concept of hope either by separating it conceptually from other phenomena such as wishful thinking, or, more generally, by seeking to minimise the negative aspects of hope, do not help us to understand the nature of hope and its functions as regards religion. Drawing on functional accounts of religion from Clifford Geertz and Tamas Pataki, who both—in their different ways—see the function of (...) religion in terms of its capacity to satisfy deep psychological needs, we demonstrate that religion uniquely positions itself with regard to hope’s two faces, simultaneously exploiting positive and negative aspects of hope. (shrink)

The debate over the constitutional recognition of Indigenous peoples is a deeply political one. That might appear to be a controversial claim. After all, there has been much talk about minimising the scope for disagreement between ‘constitutional conservatives’ and supporters of more expansive constitutional recognition. And there is concern to ensure that any potential referendum enjoys the maximum conditions and opportunity for success. However, my argument shall be that any form of constitutional recognition of Australia’s First Peoples needs to be (...) seen as part of an ongoing transformation in the relations between Indigenous peoples and the Australian state. (shrink)

I argue that there is nothing in Kant’s moral theory that legitimates condemnation of same-sex relations and that the arguments from natural ends Kant relies on in doing so are unjustified by the constraints placed upon morality to avoid the empirical determination of judgments. In order to make clear why same-sex activity does not contradict the requirements of the moral law, we need to understand Kant’s account of legitimate sexual activity. I provide this reconstruction in the first section, drawing upon (...) the Lectures on Ethics and Metaphysics of Morals. In the second section, I critique the first kind of argument that grounds Kant’s assessment, that from natural ends. I show how it is based upon underlying teleological premises and raise doubts concerning Kant’s reliance on “regulative ideas” in making a consistent ethical theory. In the third section, I argue that same-sex activity that conforms to the conditions of the moral law, especially given the concepts of consent and reciprocity, are in conformity with Kant’s formal requirement of the law of pure practical reason, and therefore cannot justifiably be condemned on those grounds. Finally, I conclude with some discussion about Rawls and political liberalism. I hope to show how the present Kantian revival in ethical theory can place itself in opposition to the conservative and homophobic hysteria surrounding debates on political and legal issues such as same-sex “marriage.”. (shrink)

My aim in this chapter is to take the complexity of our histories of rights as seriously as the nature of rights themselves. Let me say immediately that the point is not to satisfy our sense of moral superiority by smugly pointing out the prejudices found in arguments made over three hundred years ago. We have more than our own share of problems and prejudices to deal with. Rather, in coming to grips with this history, and especially how early-modern political (...) theorists struggled with the extension and application of natural rights to the ‘New World’, we may learn something about our own struggles to extend human rights beyond the boundaries of the state system of which Grotius, Hobbes, Locke and Vattel were among the key intellectual architects. For Richard Tuck, the autonomous rights-bearing agent at the heart of liberal individualism is a product of seventeenth-century theorizing about the nature of the autonomous state acting in the international sphere. The sovereign individual is the ‘traditional cousin of the sovereign state’, argues Tuck, and especially the aggressive, violent, and minimally constrained relative described by Hugo Grotius, Thomas Hobbes, John Locke and Emer de Vattel. Thus the connection between liberalism and imperialism, on this reading, is not merely chronological or historical but metaphysical. The analogy between the sovereign state and the sovereign individual acting on the basis of their natural rights, constrained by the recognition of the basic rights of others (but not much more than that) represents an influential vision of liberal freedom. This minimalist account of freedom represents only one vision, however, and Tuck’s account of the pre-history of liberal rights has to be balanced against other conceptions, including more emancipatory ones. (shrink)

In this paper I explore the implications of the notion of hyperspace for scientific realism and the sort of theoretical activity represented by the attempt to arrive at a literal characterization of the noumenal realities that natural science, especially physics, investigates. I conclude that whether or not this enterprise is possible, its being so depends on factors outside of our control for which no internal means of correction is possible. Only a very attenuated form of scientific realism, then, can reasonably (...) be endorsed by sober philosophy. (shrink)