Background: Microbiome biomarker discovery for patient diagnosis, prognosis, and risk evaluation is attracting broad interest. Selected groups of microbial features provide signatures that characterize host disease states such as cancer or cardio-metabolic diseases. Yet, the current predictive models stemming from machine learning still behave as black boxes and seldom generalize well. Their interpretation is challenging for physicians and biologists, which makes them difficult to trust and use routinely in the physician-patient decision-making process. Novel methods that provide interpretability and biological insight (...) are needed. Here, we introduce "predomics", an original machine learning approach inspired by microbial ecosystem interactions that is tailored for metagenomics data. It discovers accurate predictive signatures and provides unprecedented interpretability. The decision provided by the predictive model is based on a simple, yet powerful score computed by adding, subtracting, or dividing cumulative abundance of microbiome measurements. -/- Results: Tested on >100 datasets, we demonstrate that predomics models are simple and highly interpretable. Even with such simplicity, they are at least as accurate as state-of-the-art methods. The family of best models, discovered during the learning process, offers the ability to distil biological information and to decipher the predictability signatures of the studied condition. In a proof-of-concept experiment, we successfully predicted body corpulence and metabolic improvement after bariatric surgery using pre-surgery microbiome data. -/- Conclusions: Predomics is a new algorithm that helps in providing reliable and trustworthy diagnostic decisions in the microbiome field. Predomics is in accord with societal and legal requirements that plead for an explainable artificial intelligence approach in the medical field. (shrink)

Regulation by design (RBD) is a growing research field that explores, develops, and criticises the regulative function of design. In this article, we provide a qualitative thematic synthesis of the existing literature. The aim is to explore and analyse RBD’s core features, practices, limitations, and related governance implications. To fulfil this aim, we examine the extant literature on RBD in the context of digital technologies. We start by identifying and structuring the core features of RBD, namely the goals, regulators, regulatees, (...) methods, and technologies. Building on that structure, we distinguish among three types of RBD practices: compliance by design, value creation by design, and optimisation by design. We then explore the challenges and limitations of RBD practices, which stem from risks associated with compliance by design, contextual limitations, or methodological uncertainty. Finally, we examine the governance implications of RBD and outline possible future directions of the research field and its practices. (shrink)

This contribution aims at providing a more concrete and accurate understanding of Doughnut economics, its model, and its ideas. In doing so, it provides a comprehensive description of the Doughnut and its connection with the Sustainable Development Goals. Then, it inquires into the philosophical background of Doughnut economics, elucidating its existential rationale that relies on human dignity. Further, examples of four AI applications are used to showcase how the Doughnut model would address their use and challenges that arise thereof. From (...) this testing exercise transpires the understanding that another limitation is required in the Doughnut model, pursuant to its philosophical background. Therefore, besides economic activities that may breach the ecological ceiling or the social foundation, activities that infringe human dignity, without breaching any of the boundaries, are also incompatible with the Doughnut model. This complementing proposal is conceptually represented within the model of Doughnut economics. (shrink)

This research examines the implications of religious moderation on interfaith marriages in the city of Manado. The method used is qualitative with a case study approach; data collection is through observation, interviews, and documentation, which is then processed using the triangulation method. The findings show that religious moderation indirectly influences the sustainability of interfaith marriages in Manado. The implications are realized in the form of religious moderation, which aims to eliminate or minimize violence in the name of religion and uphold (...) diversity through upholding the values of tolerance, thereby increasing guarantees for the continuity of interfaith marriages. These implications become more complex than the laws governing interfaith marriages, especially the Marriage Law (UU Number 16 of 2019) and the Compilation of Islamic Law (KHI). The implications of religious moderation in interfaith marriages underscore the need for legal transformation that recognizes religious diversity as a social asset, encourages interreligious dialogue, and ensures that legal regulations do not hinder individual religious freedom. Encouraging policy reforms that respect differences in beliefs is crucial in creating inclusive spaces and respecting human rights in interfaith marriages. (shrink)

The research team of Madrasah Tsanawiyah Negeri 1 Bolaang Mongondow Timur has a work program called NGOBRAS RISET (Talking About Research). NGOBRAS RISET is a mentoring and training activity on research and writing scientific papers. The purpose of this activity is to provide research training and write scientific papers for students and teachers accompanying the research group. In NGOBRAS RISET IV MTs Negeri 1 Boltim invited two assistants to discuss the research proposal prepared by the research team group. In the (...) process of training, they are given knowledge about the procedure for conducting research and writing scientific papers. The results show that the MTs Negeri 1 Boltim research team group can understand the procedures for research and writing scientific papers, as well as the shortcomings contained in the proposal of the MTs Negeri 1 Boltim research team group can be overcome. (shrink)

Academic excellence and intelligence are commonly lauded as commendable attributes synonymous with success. However, a disconcerting trend has surfaced within educational institutions, challenging the prevailing narrative of scholastic accomplishment—smart shaming. This research delves into the increasing concern of smart shaming within educational settings, particularly at Immaculate Conception College of Balayan, Inc., questioning the predominant emphasis on academic excellence and intelligence. A qualitative case study design, along with judgmental sampling, was employed to examine fifteen (15) student leaders who had experienced smart (...) shaming on campus. Thematic analysis revealed that sarcastic remarks including "edi wow," "Okay ikaw na matalino," "bidabida," and "sipsip" were a prevalent manifestation of smart shaming, adversely affecting emotional well-being, academic and leadership prowess, mental health, and self-perception. Coping mechanisms, predominantly centered around ignoring and focusing on goals, were identified. The findings underscore the imperative for educators to remain vigilant regarding instances of smart shaming in classrooms, promoting open communication to ensure student well-being. Additionally, guidance counselors play a pivotal role in aiding students in effectively navigating the repercussions of smart shaming. This study advocates for proactive programs and interventions to address and alleviate the deleterious effects of smart shaming on students. (shrink)

Stereotypes within any society have consequences that are sometimes harmful and also affect targeted group of persons or ethnic group in a common way. One of the cultural stereotypes about Efik women is that they hardly believe in ‘…till death do us apart’ promised during monogamous marriage rite, that is, they walk out of marriage when conditions are unbearable. The misinterpretations of some exhortations given to the couples at Efik traditional marriage rite seem to support this claim. For example: ‘Eyen (...) mi nyamkkenyam, nnọ ke ndọ; ebot ebot edi unyam. Mm’ ifonke mendiyak, abang okubomo ikim okuwaha utong’. This exhortation is translated as: ‘I have not sold my child but given her to you in marriage; only goat is for sale. If she is no longer good for you bring her back. Let nothing malevolent happen to her.’ This implies that the life of one’s daughter is priced over marriage. One of the aims of this article is to investigate the context of this statement and how it has shaped people’s perception of marriage among the Efiks in Nigeria. In addition, this paper seeks to deconstruct some of the stereotypical views on Efik traditional marriage with regard to the female gender. Theories of Correspondent Inferences and Attribution in Social Psychology are used in understanding how women in Efik culture respond to marriage. Data from quantitative analysis of questionnaires and oral interviews threw more light on how cultural changes influence marriage institution among the Efiks. The findings of the research show that intermarriage, education, peer group influence, Western religious cultures, socio-economic conditions, etc., have necessitated the reconsideration of stereotypical views on marriage in Efik culture. (shrink)

The prevailing judgement concerning Merleau-Ponty’s encounter with Saussure’s linguistics is that, although important for the evolution of Merleau-Ponty’s philosophy of language, it was based on a mistaken or at least highly idiosyncratic interpretation of Saussure’s ideas. Significantly, the rendering of Saussure that has been common both in Merleau-Ponty scholarship and in linguistics hinges on the structuralist development of the Genevan linguist’s ideas. This article argues that another reading of Saussure, in the light of certain passages of the Course of General (...) Linguistics forgotten by the structuralists, and of the manuscripts related to the published works, shows to the contrary that Merleau-Ponty’s account was sustainable. An understanding of Saussure’s ideas that does not flinch from their paradoxical features can elucidate the French phenomenologist’s views on language and expression. Moreover, the “linguistic turn” in Merleau-Ponty’s philosophical development, identified by James Edie for example, does not seem to have been so clear-cut as has previously been believed; the influence of Saussure’s thought had certainly begun before Merleau-Ponty wrote Phenomenology of Perception -/- En français: « La rencontre de Merleau-Ponty avec la linguistique saussurienne : lecture fautive, réinterpretation ou prolongement ? » Inspirée de la linguistique Saussurienne, la philosophie du langage de Merleau-Ponty a souvent été considérée comme une interprétation erronée des idées de Ferdinand de Saussure ou tout du moins comme une traduction singulière de son œuvre. On remarque cependant que la relecture critique du linguiste genevois, qu’elle soit effectuée à partir de l’œuvre merleau-pontienne ou, plus généralement, dans le champ de la linguistique, repose en grande partie sur les modes d’analyse structuralistes. À la lumière de certains passages du Cours de linguistique générale négligés par les structuralistes, et des manuscrits qui se rapportent aux œuvres publiées, cet article défendra l’idée que l’interprétation de la pensée saussurienne par Merleau-Ponty reste à bien des égards pertinente, pour autant qu’elle ne recule pas devant les traits paradoxaux résultant de la pensée saussurienne. Un questionnement de la pensée de Saussure ne reculant pas devant ses traits paradoxaux peut contribuer à accroître notre compréhension des notions de langage et d’expression chez le phénoménologue français. Dans ce cadre, le « tournant linguistique » merleau-pontien, décrit par James Edie, ne paraît pas aussi net que l’on l’a soutenu auparavant : l’influence de la pensée de Saussure s’est certainement faite sentir avant l’écriture de Phénoménologie de la perception. (shrink)

My paper focuses on what and how Kant had accomplished with his intended “re- form of metaphysics” through “reason’s entering the secure path of science”. In this respect, I will argue that the influence of (pure) sciences on Kant’s programme was a major one, and this may be best highlighted if one assumes that he developed his mature theory only in the B edi- tion of his Critique (1787), where the influence of the model of pure a priori sciences turn (...) to be decisive. This influence, as we already know, is closely related to the “reform of metaphysics” by “reason’s entering the secure path of science”. My claim is upheld also by the historical ar- gument that only in the Prolegomena (1783) and in the B edition of the Critique Kant explicitly conceived the idea of “metaphysics as science”. Therefore, the necessary steps in dealing with “metaphysics as science” must consider the A Critique, the Prolegomena, and the B Critique in this precise order. Assuming this order, my approach will involve three parts: in the first I will investigate the idea of the reform of metaphysics from the A Critique, in the second I will take into account “reason’s entering the secure path of science” (in the Prolegomena and the B Cri- tique), i.e., philosophy as science (the discipline within the B Critique); finally, I will argue that understanding Kant’s “idea of philosophy as science” can best be achieved by focusing on the role and place that pure sciences have in the transcendental philosophy of the B Critique, where its structure and content are themed and projected within the methodological frame of the “ex- periment of pure reason”. (shrink)

Tato studie se zabývá zobrazováním alchymie v malbách, knižních ilustracích i v architektuře v období raného novověku. Na jednotlivých příkladech obrazů či ilustrací prezentuje různé aspekty alchymistova života i jeho práce. Nezabývá se symbolickou alchymickou ikonografií, ale zaměří se především na zobrazování prostředí a vybavení alchymických dílen i osobností samotných alchymistů. Soustředí se zejména na vyobrazení zařízení alchymických laboratorií, s nimiž se lze setkat jak u renesančních malířů, tak v ilustracích alchymických rukopisů a poměrně ojediněle i v české architektuře. Poskytuje (...) také pohled na vyobrazení vzniklá v souvislosti s literární kritikou alchymie. Alchymisté byli zejména v dílech předních evropských humanistů často záměrně zesměšňováni, kritizováni a označováni za blázny a zloděje. V závěru se zabývá vybranými příklady ze žánrového umění, kde byli rovněž alchymisté zobrazováni často satiricky, ale i s určitou úctou, jako vzdělaní učenci. Výtvarné umění raného novověku nám představuje různé aspekty života alchymistů a je v dnešní době jednou z možností, jak se přiblížit porozumění jejich vědeckým aktivitám. Jak však studie ukazuje, k těmto obrazovým materiálům je třeba přistupovat kriticky. (shrink)

Teaching at a private, conservative religious institution poses unique challenges for equality, diversity, and inclusivity education (EDI). Given the realities of the student population in the Honors College of a private, religious institution, it is necessary to first introduce students to the contemporary realities of inequality and oppression and thus the need for EDI. This chapter proposes a conceptual framework and pedagogical suggestions for teaching basic concepts of social justice in a team-taught, interdisciplinary social science course. The course integrates four (...) different approaches to justice: theoretical, social scientific, narratological, and experiential. The discussion of the experiential dimension of the course references practical pedagogical strategies for making social justice and inequality real for our students. Understanding the realities of social inequality and its roots can foster a better understanding of the social forces and structures that perpetuate inequality. Furthermore, this approach can plant the intellectual and empathic seeds to challenge in-group bias and hopefully germinate into fruitful interaction with diverse others. Finally, this rich, interdisciplinary encounter with social inequality and justice can prepare students to work for just social structures that will lead to a more inclusive world. (shrink)

Tato studie je recenzní statí ke knize Andrew MCGETTIGAN, The Great University Gamble: Money, Markets and the Future of Higher Education. London: Pluto Press, 2013. Klíčovým motivem studie je využití McGettiganovy analýzy technických aspektů reformy univerzitního systému započaté v Anglii na konci první dekády jednadvacátého století pro výklad vzestupu specifického režimu vzdělávání vyjádřeného v jazyce a logice „trhu a peněz". Vzestup tohoto režimu je interpretován s ohledem na procesy odpojování univerzitního prostředí od dosavadního vzdělávacího rámce spojeného s veřejnými zájmy. Studium (...) způsobů, jakými procházejí peníze zaváděným systémem vzdělávání, odkrývá novou podobu konfrontace klasických ideálů univerzitní výchovy s realitou masového vzdělávání. (shrink)

Tato studie se zabývá dvěma spřízněnými jevy odehrávajícími se ve vědeckém prostředí. Jedná se o fenomén frustrace ve vědecké praxi a s ním spojenou touhu po rozpoznání vlastního výzkumu vědeckou komunitou a následně o otázku uznání od akademického společenství. Zmíněné fenomény jsou přitom úzce propojeny s ústředním tématem filosofie a sociologie vědy: kdo rozhoduje, co bude předmětem vědeckého bádání? Předkládaná studie nejprve představuje Mertonův mýtus o okamžitém rozpoznání vědeckého objevu a následně prostřednictvím exkurzu do oblasti ekonomie a na příkladech z (...) vědecké praxe poukazuje na jeho neplatnost. V závěru textu jsou společně s jejich dekonstrukcí navrhnuta možná řešení popsaných problémů. Text je také kritickým návratem ke dvěma studiím Josepha Agassiho, žáka Karla R. Poppera a tvrdošíjného zastánce kritického racionalismu, neboť právě Agassi ve svých dílech rozebírá dopady vědeckého vyloučení a neochoty naslouchat. (shrink)