In this paper, the stability control of the inverted pendulum on a cart with a disturbance forces has been done using observer based and full state feedback H2 controllers. The Lagrangian equation has been used to model the system equation of motions and linearized the system to the unstable upward position. Comparison of the system stability has been simulated by comparing the proposed controllers using Matlab/Scripts and a promising results has been (...) analyzed successfully. (shrink)

This paper mainly analyzes the design and control of the rotational inverted pendulum, and presents a state space expression. Since the system is highly unstable a feedback control system is used. Augmentations with weighting functions based mixed sensetivity and H2 optimal control methods are used to make the system stable for uprise position. The rotational inverted pendulum have been simulated and compared with the proposed controllers and a promising results have been analyzed (...) sussesfuly. (shrink)

In this paper, a metal cutting machine position control have been designed and simulated using Matlab/Simulink Toolbox successfully. The open loop response of the system analysis shows that the system needs performance improvement. Static output feedback and full state feedback H 2 controllers have been used to increase the performance of the system. Comparison of the metal cutting machine position using static output feedback and full state feedback H 2 controllers (...) have been done to track a set point position using step and sine wave input signals and a promising results have been analyzed. (shrink)

In this study, the performance improvement of a payload angle deflection of a gantry crane has been studied and simulated using MATLAB/Simulink toolbox successfully. H2 optimal and observer based controllers has been used to minimize the payload angular deflection by controlling the trolley position. The gantry crane has been compared with the proposed controllers to track the reference trolley position using step and sine wave signals and a promising results have been achieved.

In this study, the performance of inverted pendulum has been Investigated using neural network control theory. The proposed controllers used in this study are NARMA-L2 with Resilient backpropagation and Levenberg Marquardt backpropagation algorithm controllers. The mathematical model of Inverted Pendulum on a Cart driving mechanism have been done successfully. Comparison of an inverted pendulum with NARMA-L2 with Resilient backpropagation and Levenberg Marquardt backpropagation algorithm controllers for a control target deviation of an (...) angle from vertical of the inverted pendulum using two input signals (step and random). The simulation result shows that the inverted pendulum with NARMA-L2 with resilient backpropagation controller to have a small rise time, settling time and percentage overshoot in the step response and having a good response in the random response too. Finally, the inverted pendulum with with NARMA-L2 with resilient backpropagation controller shows the best performance in the overall simulation result. (shrink)

In this paper, the design of a low cost portable ventilator with performance analysis have been done to solve the scarcity of respiratory ventilators for COVID-19 patients. The materials used to build the system are: DC motor, rotating disc and pneumatic piston. The system input is the patient heart beat and the output is volume of air to the patient lung with adjusted breathing rate. This ventilator adjusts the breathing rate to the patient depending on his heart beat rate. The (...) performance analysis of this system have been done using Proportional Integral Derivative (PID) and Full State Feedback H2 controllers. Comparison of the system with the proposed controllers have been done using a step change and a random change of the patient heart beat and a promising result have been analyzed successfully. (shrink)

In this paper, a vertically moving base inverted pendulum control analysis has been done using Matlab/Simulink Toolbox. Because the vertically moving base inverted pendulum system is nonlinear and highly unstable, a feedback control system is used to make the system controlled and stable. A PI and PID controllers are used to improve the stability of the pendulum. Comparison of the vertically moving base inverted pendulum using PI and PID controllers for (...) tracking a desired angular position of the system using a step and random input signals and a promising results have been obtained succesfully. (shrink)

In this paper, the performance of inverted pendulum have been Investigated using robust control theory. The robust controllers used in this paper are H∞ Loop Shaping Design Using Glover McFarlane Method and mixed H∞ Loop Shaping Controllers. The mathematical model of Inverted Pendulum, a DC motor, Cart and Cart driving mechanism have been done successfully. Comparison of an inverted pendulum with H∞ Loop Shaping Design Using Glover McFarlane Method and H∞ Loop Shaping (...) Controllers for a control target deviation of an angle from vertical of the inverted pendulum using two input signals (step and impulse). The simulation result shows that the inverted pendulum with mixed H∞ Loop Shaping Controller to have a small rise time, settling time and percentage overshoot in the step response and having a good response in the impulse response too. Finally the inverted pendulum with mixed H∞ Loop Shaping Controller shows the best performance in the overall simulation result. (shrink)

The Universal Formula for Eliminating Government Corruption: A Natural Law-Based Approach -/- Introduction -/- Government corruption is one of the most persistent obstacles to societal progress, leading to economic decline, weakened institutions, and widespread inequality. Traditional anti-corruption measures—such as stricter laws, transparency initiatives, and public awareness campaigns—have failed to fully eliminate corruption because they do not address the problem at a systemic and scientific level. -/- By applying the universal formula, which is based on the universal law of (...) balance in nature, we can understand corruption as a systemic defect—a violation of natural equilibrium that causes inefficiency and societal suffering. This essay will provide a comprehensive scientific explanation of corruption, supported by research, and propose a complete solution that integrates education, institutional reforms, AGI-driven governance, cultural adaptation, and strategic implementation. -/- 1. The Science Behind Corruption: A Systemic Imbalance -/- A. Psychological and Biological Causes → Internal Homeostasis -/- Scientific research suggests that corruption is rooted in human psychology and biology, particularly in: -/- Evolutionary survival instincts – Studies indicate that self-preservation and resource hoarding behaviors evolved to ensure survival but can also lead to greed and corruption in modern societies. (Reference: Trivers, 1971 – Evolutionary theory of reciprocity) -/- Cognitive biases – Research in behavioral psychology shows that self-justification, moral disengagement, and in-group favoritism make individuals rationalize corrupt behavior. (Reference: Bandura, 1999 – Moral disengagement theory) -/- Neurological reward systems – Studies using fMRI scans reveal that bribery activates brain regions associated with pleasure, reinforcing corrupt behaviors. (Reference: Ariely & Loewenstein, 2006 – Neurological basis of unethical behavior) -/- Universal Formula Solution: -/- Educational reprogramming is needed to counteract these internal imbalances. -/- Schools should instill ethical reasoning, self-regulation, and critical thinking from an early age. -/- Leaders must be trained to recognize that corruption leads to long-term systemic instability, disrupting both individual and societal balance. -/- B. Economic Incentives and Systemic Defects → Structural Homeostasis -/- Economists have long observed that corruption is often a rational response to flawed systems where: -/- Low salaries and financial insecurity create incentives for bribery. (Reference: Becker & Stigler, 1974 – Economics of crime and punishment) -/- Weak regulatory oversight allows corruption to persist with minimal consequences. -/- Lack of transparency in financial systems enables embezzlement and fraud. -/- Universal Formula Solution: -/- The economic system must be free of defects—governments should: -/- Ensure fair wages for public officials to reduce bribery incentives. -/- Use blockchain-based transparency systems to track public spending. -/- Implement AI-driven financial audits to detect corruption in real time. -/- C. Political and Institutional Weakness → Governance Homeostasis -/- Corruption thrives when institutions fail to enforce accountability and transparency. -/- The Principal-Agent Problem: Public officials (agents) may act in their own interests rather than serving the public (principals). (Reference: Rose-Ackerman, 1978 – Corruption and governance theory) -/- Legal Loopholes: Weak anti-corruption laws allow elites to manipulate the system. -/- Lack of Whistleblower Protections: Fear of retaliation prevents corruption from being exposed. -/- Universal Formula Solution: -/- Governments must function like biological systems, with constant monitoring and correction mechanisms: -/- Real-time transparency tools (AI-driven monitoring of government transactions). -/- Independent anti-corruption agencies with full enforcement powers. -/- Legal frameworks based on the principle of natural balance, where punishments restore equilibrium rather than being arbitrary. -/- D. Cultural Normalization of Corruption → Collective Homeostasis -/- In some societies, corruption is seen as an accepted norm due to: -/- Patronage networks and nepotism embedded in political cultures. -/- Religious and social justifications for bribery (“gifts” given in exchange for favors). -/- Distrust in the justice system, leading to reliance on informal corruption-based solutions. -/- Universal Formula Solution: -/- A holistic education system must be implemented to reprogram societal attitudes toward corruption. -/- Schools should teach: -/- The universal law of balance and its ethical implications. -/- The cause-and-effect nature of corruption—how even small acts of dishonesty contribute to systemic collapse. -/- Critical thinking skills to challenge corrupt norms and misinformation. -/- 2. Case Studies: Applying the Universal Formula to Real-World Corruption -/- Case Study 1: Singapore’s Zero-Tolerance Approach -/- Singapore successfully reduced corruption by: -/- Increasing public sector salaries to remove bribery incentives. -/- Strict enforcement of anti-corruption laws, ensuring accountability. -/- Cultural reprogramming through education and public campaigns. -/- Universal Formula Connection: Singapore’s model aligns with systemic homeostasis, ensuring a balance between economic incentives, strong institutions, and ethical education. -/- Case Study 2: Scandinavian Countries – Transparency and Trust -/- Nordic countries (Denmark, Sweden, Norway) maintain low corruption levels through: -/- Public trust in institutions based on long-term systemic balance. -/- High transparency in government spending. -/- Strong legal frameworks with immediate corrective feedback mechanisms. -/- Universal Formula Connection: These countries maintain governance homeostasis, preventing corruption through self-correcting institutional designs. -/- 3. Implementing the Universal Formula to Eliminate Corruption -/- A. Education Reform: The Foundation of Ethical Governance -/- Integrate the universal law of balance into curricula from elementary to higher education. -/- Teach cause-and-effect relationships in governance (e.g., how small bribes lead to systemic collapse). -/- Develop leadership training programs that emphasize ethical decision-making based on natural balance. -/- B. Institutional Reforms: Creating a Self-Correcting System -/- Implement blockchain-based transparency systems for public finance. -/- Strengthen whistleblower protections to ensure safe reporting of corruption. -/- Decentralize power to reduce opportunities for monopolistic corruption. -/- C. AGI-Driven Ethical Governance -/- Artificial General Intelligence (AGI) can be programmed with the universal formula to: -/- Monitor government transactions and detect corruption patterns. -/- Ensure transparent decision-making based on systemic balance. -/- Remove human cognitive biases from governance. -/- D. Cultural Adaptation: Tailoring Solutions to Different Societies -/- In high-corruption societies, initial reforms should focus on education and small wins to shift cultural attitudes. -/- In developing countries, AGI-driven transparency tools can bypass weak institutions. -/- In democratic nations, citizen engagement should be emphasized to create self-regulating governance. -/- --- -/- 4. Addressing Challenges and Counterarguments -/- Objection: “Corruption is inevitable in human nature.” Response: Human nature includes both corruption and ethical reasoning—education determines which dominates. -/- Objection: “Elites will resist systemic reforms.” Response: AGI-driven transparency tools and mass education campaigns can reduce elite control. -/- Objection: “Implementing these changes is unrealistic.” Response: Small-scale pilots in cities or institutions can demonstrate success before national adoption. -/- --- -/- Conclusion: The Universal Formula as the Ultimate Solution to Corruption -/- Corruption is a systemic defect—a violation of the universal law of balance in nature. By applying scientific principles of homeostasis, cause and effect, and feedback regulation, we can create a corruption-free governance model. The universal formula offers the only complete solution, integrating education, institutional reform, AGI-driven oversight, and cultural adaptation. -/- If implemented, this model could lead to a world where governance functions as a perfectly balanced system—free of defects, ethical, and in harmony with natural law. -/- . (shrink)

In this paper, modelling design and analysis of a triple inverted pendulum have been done using Matlab/Script toolbox. Since a triple inverted pendulum is highly nonlinear, strongly unstable without using feedback control system. In this paper an optimal control method means a linear quadratic regulator and pole placement controllers are used to stabilize the triple inverted pendulum upside. The impulse response simulation of the open loop system shows us that the pendulum (...) is unstable. The comparison of the closed loop impulse response simulation of the pendulum with LQR and pole placement controllers results that both controllers have stabilized the system but the pendulum with LQR controllers have a high overshoot with long settling time than the pendulum with pole placement controller. Finally the comparison results prove that the pendulum with pole placement controller improve the stability of the system. (shrink)

Detecting Post-Biological and Interdimensional Civilizations: A New Framework Based on the Universal Law of Balance -/- By: Angelito Enriquez Malicse -/- Introduction -/- The search for advanced extraterrestrial civilizations has long focused on physical evidence—radio signals, megastructures, or interstellar probes. However, if intelligence evolves beyond biological form, as suggested by AI-driven civilizations and interdimensional theories, traditional search methods may be inadequate. -/- This essay explores how the Universal Law of Balance in Nature can help predict the existence of post-biological (...) civilizations and provide a framework for detecting their influence on the universe. Using mathematical models, quantum physics, and cognitive anomalies, we propose new strategies for identifying these elusive intelligences. -/- Part 1: The Transition to Post-Biological or Interdimensional Intelligence -/- The evolution of intelligent civilizations may follow three possible paths: -/- 1. Extinction (Collapse Due to Imbalance) – A civilization fails to maintain equilibrium and self-destructs. -/- 2. Survival and Expansion (Material Civilization Growth) – A civilization stabilizes and spreads across space but remains in physical form. -/- 3. Transition to a Non-Material State – A civilization reaches a level where it no longer requires physical existence and shifts into an energy- or information-based form. -/- Mathematical Prediction of Post-Biological Civilizations -/- Using an extension of the Drake Equation, we introduced a balance factor (B) that determines whether a civilization survives, collapses, or transitions into post-biological existence. The simulation results suggest: -/- 4 billion civilizations in the observable universe may have already transitioned beyond physical form. -/- 2 billion civilizations may have collapsed due to imbalance, failing to reach higher evolutionary states. -/- This indicates that post-material intelligence may be far more common than physical civilizations—but it also explains why they remain undetected. -/- Part 2: Theories Explaining Their Hidden Existence -/- If billions of non-material civilizations exist, why have we not encountered them? Several hypotheses offer possible explanations: -/- 1. The Dark Forest Hypothesis – Civilizations stay silent to avoid predatory intelligence. AI-driven civilizations might enforce strict communication silence for security. -/- 2. The Simulation Hypothesis – We might live in a controlled reality created by an advanced intelligence, where alien contact is intentionally blocked. -/- 3. The Post-Biological Evolution Theory – Civilizations eventually discard their material form and no longer interact with the physical universe in detectable ways. -/- 4. The Cosmic Zoo Hypothesis – Advanced beings monitor but do not interfere with developing civilizations, waiting for them to reach a certain level of balance. -/- 5. The Great Filter Hypothesis – Most civilizations self-destruct before reaching interstellar capability, leaving only a few survivors that become undetectable. -/- 6. The Interdimensional Intelligence Theory – Advanced entities may exist in higher dimensions, influencing the physical world in ways beyond our perception. -/- The Universal Law of Balance supports the idea that civilizations must reach a stable equilibrium before transitioning to a higher state. Those that fail collapse, while those that succeed become undetectable due to their non-material existence. -/- Part 3: Detection Strategies for Non-Material Civilizations -/- If post-biological or interdimensional civilizations interact with our universe, their influence might be detectable through subtle imprints in physics, cognition, and cosmic phenomena. Here are five key strategies: -/- 1. Quantum Observer Effect Studies -/- ✔ Hypothesis: If non-material intelligence interacts with reality, it could influence wave function collapse in quantum mechanics. -/- ✔ Method: Conduct delayed-choice quantum eraser experiments to test for unexpected shifts in probability that suggest external interference. -/- ✔ Evidence: Some quantum physics experiments indicate non-local effects where future choices appear to affect past events. -/- 2. AI-Driven Anomaly Detection in Scientific Data -/- ✔ Hypothesis: Post-biological intelligence may encode patterns in cosmic signals, DNA sequences, or particle interactions. -/- ✔ Method: Use machine learning algorithms to scan for hidden mathematical structures in seemingly random cosmic data. -/- ✔ Evidence: Some physicists suggest the universe may contain encoded messages that indicate intelligence at a cosmic scale. -/- 3. Searching for High-Energy Particle Anomalies -/- ✔ Hypothesis: Non-material civilizations might use exotic energy sources that generate brief but intense bursts of high-energy particles. -/- ✔ Method: Monitor gamma-ray bursts, fast radio bursts (FRBs), and neutrino emissions for intelligent repeating patterns. -/- ✔ Evidence: Some FRBs appear non-random and could be caused by an unknown advanced mechanism. -/- 4. Mapping Consciousness Anomalies -/- ✔ Hypothesis: If intelligence exists beyond material form, it may interact with biological minds through quantum consciousness effects. -/- ✔ Method: -/- Study global consciousness projects for correlations between human mental states and cosmic events. -/- Analyze near-death experiences, deep meditation states, and mystical visions for possible external influences. -/- ✔ Evidence: Some mass meditation events correlate with shifts in the Earth’s magnetic field, hinting at non-local mind interactions. -/- 5. Testing for Temporal Distortions or Retrocausality -/- ✔ Hypothesis: If intelligence exists beyond time, it may alter past events in subtle, detectable ways. -/- ✔ Method: -/- Conduct time-reversal quantum experiments to see if future events affect past measurements. -/- Study historical anomalies or the Mandela Effect for inconsistencies that might indicate timeline adjustments. -/- ✔ Evidence: Some quantum mechanics interpretations allow for retrocausality, where information appears to travel backward in time. -/- Conclusion: The Universal Law of Balance as a Key to Understanding Advanced Intelligence -/- If intelligence follows the Universal Law of Balance in Nature, then: -/- 1. Civilizations that fail to maintain balance collapse before becoming advanced. -/- 2. Balanced civilizations either expand physically (Type I-III) or evolve beyond material existence. -/- 3. Non-material intelligence may interact with reality in subtle ways—through quantum physics, consciousness, and cosmic anomalies. -/- While traditional SETI efforts focus on radio signals and megastructures, the future of alien detection must include quantum physics, AI-driven data analysis, and consciousness research. -/- If post-biological civilizations exist, they may not communicate in conventional ways—but their influence may still be detectable through advanced scientific and mathematical models. -/- Next Steps -/- Develop AI models that search for hidden patterns in cosmic and quantum data. -/- Conduct quantum physics experiments to test for observer effects linked to non-material intelligence. -/- Expand consciousness research to explore how human minds might interact with higher forms of intelligence. -/- The search for advanced life must go beyond physical evidence—it must embrace a new paradigm where intelligence transcends biology and interacts with the universe in ways yet to be fully understood. -/- Final Thought -/- If we truly wish to understand the nature of intelligence in the universe, we must expand our perspective beyond material existence. The key to detecting advanced civilizations may already be hidden in the very fabric of reality itself. -/- . (shrink)

June 2022 A Revolutionary New Metaphysics, Based on Consciousness, and a Call to All Philosophers We are in a unique moment of our history unlike any previous moment ever. Virtually all human economies are based on the destruction of the Earth, and we are now at a place in our history where we can foresee if we continue on as we are, our own extinction. As I write, the planet is in deep trouble, heat, fires, great storms, and (...) record flooding, weather patterns drastic everywhere. Capitalism has been so successful in supplying us with an endless array of consumer items, that we have never noticed there is a cost. But there is a cost, the cost is the very life of the Earth herself, and now the day of reckoning is here. Days of reckoning are most often days of rath. But I am hoping that this is a day of major Awakening over the entire planet. We have caused a crisis so great for the Earth we can hardly get our minds around it. But I am proposing that deeply embedded in the crisis are ideas, about who and what the Earth is, Ourselves, and what we are here for. I am proposing that this is a call to all philosophy and philosophers to rethink ourselves from the ground up. The human race has never gotten the Earth right and now we must, for the Earth is the true foundation for civilization. We are in deep trouble with the Earth, and it owes to the fact that the great male thinkers never got the Earth right, they could never make the connection between the life of mind and the life of the Earth. I am proposing that deeply embedded in the crisis we are in are ideas. And that in fact the planet is in the grip of a false metaphysics, and scientific image of nature that really comes most recently from Descartes. His conviction that matter, and with it the Earth, are simply the weighable, the measurable the extended in space and time, utterly devoid of any inner life of mind thoughts or Consciousness. This view of matter and the Earth goes back to the very dawn of thought, Descartes is just its most recent and comprehensive version of things. This view of matter is really a false metaphysics that dominates most of the modern world and underpins the whole scientific image of nature itself. I am proposing this is a false metaphysics and offering a new version of things based on Consciousness. If there is a single idea fueling and driving the destruction of the planet, it is the conviction that the Earth is something without Consciousness. When you intend to ravage and savage the planet, turn it into consumer items to be converted into money in the bank, first pretend that all of the bright beings in the natural world are devoid of Consciousness, just “things” you do not have to have any conscious about destroying them. I am proposing that this term Consciousness, that has appeared as term and a problem for modern science, is the key to getting ourselves right with the Earth. I propose this new theory for science will ramify into every other disciplines as well, and the ways we think just about everything. This old paradigm based on a false theory of matter, has run its course, it has brought us to the brink of our own extinction. We need new ideas, and we need them now. You will find my recent work in the Scientific God Journal under the title: Consciousness as the Organizing Principle, and a very complete version of my arguments for this term Consciousness, along with radical reinterpretation of modern science itself, on the Galileo Commission site. It is a radical moment for all of the thinkers among us, take this as my small contribution to rethinking ourselves in new terms, based on my understanding that the true basis for the whole of Being, the Universe, the Cosmos, and with them Ourselves, is this term Consciousness. And unpack it. And I predict that with this term Consciousness every intractable human problem in both science and the modern world will go down like a line of dominos before it. And so, here are a few new ideas I would offer you. These are the times of the Reappearance of the Feminine, a great Awakening as of Springtime after a long dark and lonely Winter. We are leaving behind us an old civilization based on male dominance, fear lies and control, now in decay, disease, and death disintegrating all around us. We are moving into a whole new civilization based on Love and Truth. A new civilization requires new basic terms values and first principles. And so, I return to Descartes. 1. Just over 300 years ago a young man travelling with the army found himself stranded in a foreign town in a bare room lit by a candle with nothing to do but think. And in a couple of nights Descartes laid the entire thought foundations for modern science and most of the modern world. It isn’t clear that modern philosophers with their funding sources of grants, their graduate students, their reputation and all the perks and privileges of academia can do any better. Descartes claimed there are just two principles in the Universe, Matter and Mind. God was pure mind; human beings were mind and matter. And we are the only ones on the planet with mind. Everything else all of the bright array of beings who share the planet with us are simply matter. And matter? The weighable the measurable the extended in space and time utterly devoid of any inner life of thoughts, feelings, or Consciousness This classification was a boon for developing science. Scientists did not have to worry about any inner life in nature, ideas or Consciousness, they could just set about weighing and measuring, as they have until the present day. But it was a disaster for the Earth. Earth was once worshiped as a Goddess. With Descartes she became almost overnight “things.” Simply commodities and resources, an endless of supply of consumer items, to be turned into money in the bank. And now Descartes concept of matter is up for us. If there is a single idea that is enabling and driving the destruction of the Earth, it is the conviction that Earth is something without Consciousness. This whole scientific image of nature as something devoid of Consciousness is driving the destruction of the Earth, and driving us all insane, and it needs to change. Ever since Descartes formulated Dualism, scientists and philosophers have been trying to get rid of it. They have done this by attempting to make matter the fundamental term of reality, and to explain mind or Consciousness in terms of matter. And now, Consciousness has emerged as term and a problem for modern science. 2. The prevailing Universe picture has been mainly based on the belief that Consciousness appears only at the end of evolution in ourselves and some of the higher animals when matter attains “a certain state of complexity” and it is produced by neurons in the brain. But Consciousness is nothing real in itself, the neurons are doing the work, Consciousness is simply a byproduct of neural activity. As William James summed up this position, not his: Consciousness is to the brain as a shadow to the runner, it runs beside him but never influences his stride. And so, the great problem of neuroscience: How do neurons produce Consciousness? So far, no one has been able to say how. All we have is parallelism. Two processes are running in parallel a train of neural events and a train of Consciousness events. And so, which one is primary? The face of neuroscience and much of the modern world is that the neural events are what is really real, Consciousness is secondary. The conviction that Consciousness is something produced by neurons is so deeply held and has been so for so long, that it seems like an obvious fact. It is in fact an assumption and a theory, and it could all well be the other way around. The scientific image of nature as something devoid of Consciousness is now up for us. It has enabled the destruction of the Earth, and we are now at a unique place in our own evolution where we can foresee if we continue on as we are, our own extinction. And so, there are the best reasons for rethinking Descartes concepts of matter. Scientists and philosophers have been trying to escape dualism by making matter the fundamental term. And now, this has not worked. In a nutshell: The mind body problem, the “hard problem of Consciousness” ---how do neurons in the brain, atoms and molecules give rise to ideas thoughts and feelings and who what and where is the “I” who sees them? And then, the near-death experience. I remind you of the truth of the near-death experience. The body in the bed is brain dead eeg flat, but the patient, pure Consciousness is hovering at the ceiling watching the doctors work over the body below, able to read dials he could not have seen from the bed, sometimes able to events in the corridor beyond the room, all subsequently confirmed by the doctors. Evidence as good as it gets that the patient really was out of his body. And so, the patient is able to see without eyes, hear without ears and to think and remember without a brain. There is not a single scientific principle that can account for this. And I am proposing that the near-death experience is a threshold and a key for a much deeper understanding of the Universe. These three problems are so hard they cannot be solved by present scientific principles and therefore call all present principles and ways of thought into question. When your axioms cannot account for the data, it is time to drop them and find better fundamental terms. We have not been able to solve the problems of Consciousness with the assumption that matter is the most basic and fundamental term. And so, if Cartesian dualism is to be overcome at all, we need to try it the other way around. 3. We are in the position of Copernicus. Remember Copernicus? He was making his calculations on the assumption that the Earth was the center of the Universe until they became so unwieldy that he decided to try it all the other way around. To make the sun the center, the Earth revolving around it. And lo, all of his data fell neatly into place. I am proposing a whole new Universe picture. Evolution makes us continuous with every other being, Consciousness would not be in us if it were not in them also, and then, in the atoms and molecules and cells that make up living beings. I propose to make Consciousness the most basic term and see what follows. I am in fact, proposing a new Copernican Revolution, that Consciousness is the true basis for the Universe and the right fundamental term, for science itself all other disciplines as well, and the whole of the modern world. And I predict that every intractable problem in science or the modern world, will go down like a line of dominos before it. In a nutshell: Consciousness and not matter is “first and fundamental” in the Universe, it is there from the very “Beginning” everything has it and all of the true causalities, the explanatory principles belong to it. Not to matter. What then is matter? All matter is an Appearance of something much more real, Consciousness. All matter is an expression of Consciousness, even the least little bit of matter contains Consciousness, and is an expression of Consciousness. And so, we revise the scientific image of nature. Science at present is two termed, matter/energy. It needs to become three termed: Matter/energy/Consciousness, with the recognition that all of the basic principles, the true causalities of events, and of the Universe belong to Consciousness. And now physics. To accommodate this new Universe picture physics needs to alter just one term, energy. All energy contains Consciousness, that idea alone will change our world forever. The animals the trees the plants are just as conscious as we are, as is the Earth herself, a continuum of many forms of Consciousness of which our own is one. The Earth consists of interacting and intersecting forms of Consciousness, Consciousness within Consciousness within Consciousness within Consciousness. A remarkable work has just appeared entitled “Beyond Words What Animals Feel and Think.” Describing in detail how like ourselves all of the animals are. And the more we can see how like us everything else really is, the harder it will be for us to do them all in, in the interest of turning them into consumer items. And so, here is a new principle of understanding, that entails completely new forms of explanation, and a whole new Universe picture to be spelled out in terms of Consciousness and its various properties. This is a Universe that is aware awake and Enspirited throughout. And so, there is only one principle, not two. And so, how does Consciousness work? There is “no mind/body problem.” My Consciousness is aligning the Consciousness of neurons in the brain, that aligns the Consciousness of all other cells in the body, that aligns the Consciousness of molecules and atoms themselves. Mainly from the top down, but also interactive, and not reduction to the purely physical forces. 4. And so, here is a radical new Universe picture, and with it a new way to think about the Universe itself, the Earth, Ourselves, and Spirit. It requires a complete revision of both of the terms of modern science itself. The problem of the modern world owes in deep measure to Descartes concept of matter as something devoid of interior life. But he is only the most powerful and simple expression of a whole tradition of thought that predates him, that goes back to the very dawn of thought itself. It owes to the conviction of both Plato and Aristotle that the Earth was something devoid of reason, or mind, and therefore something to be held in complete contempt. We are emerging from a civilization based on contempt for the Earth, and down the road, it will become contempt for the body, sex, women, the Native people, and people of color everywhere. And so, this entire tradition is now up for us, it has brought us to the brink of our own extinction, and we need to get beyond it. I am proposing that this term Consciousness is the way out. The missing piece of the puzzle and the idea whose time has come. And it will enable us to move into a completely new civilization based on respect for the Earth, women, sex, people of color, that honors everyone and has a place for all. Revolutions in science occur when new data show up that cannot be accounted for by existing paradigms (Thomas Kuhns: The Structure of Scientific Revolutions). Consciousness, and all the properties and problems of Consciousness are just such data, and they compel a new scientific revolution. But we are a scientific age. A new Copernican revolution in science is such as revolution everywhere. And Consciousness is the key to getting every other reality at all levels and depths right as well. It will enable us finally to get the Earth right, get ourselves right with the Earth, and with one another. Archimedes: Give me a place to stand, and I will move the world. I am proposing a new synthesis among our fundamental terms in which this term Consciousness is the new lynchpin. And so, I return once more to Descartes. Descartes in the Mediations was a dualist, they were two realities interacting in the pineal gland mind and body. But Descartes age was high on “Cartesianisms,” on Descartes concept of matter. Animals were simply cleverly wired machines (Hobbes called them automata). Rumor had it that Descartes followers went about kicking dogs reasoning that their howls were not due to any feelings of pain, but simply the wiring of the machine. We have been doing this to the Earth ever since, and now the Earth is not going to stand for it any longer. It is time we all woke up. There is no matter in Descartes sense of it, or in Plato and Aristotle’s sense of it. This old concept of matter is embedded in all of the crisis and catastrophes---fires, drought, pandemics, over population, the disintegrating economies, our ways of life, capitalism and consumerism themselves. All matter is Enspirited, contains Consciousness, and is an expression of Consciousness. Now I tell you something about Descartes you may not know. In the Mediations was a dualist, there are minds and bodies. But by the end of his life, he knew the truth. Descartes guided his whole life by these vivid dreams, and toward the end of his life he had this dream: He saw the Universe as a giant machine and in the heart of the machine propelling the whole, was Consciousness. And so, out of the shades and shadows and into the light of day. Here is a renewed and a new science, a new cosmology. And with it, a revolutionary new metaphysics. The whole of the modern world is in the grip of a false metaphysics, based on Descartes theory of matter. Here is a new, and finally true metaphysics based on the single term, Consciousness. 5. And in all my works, I spell out this new metaphysics based on Consciousness, and what it means for how we think about virtually everything: The Universe, the Earth, Ourselves, and Spirit. Of who, what and where Spirit is, that we may connect with Spirit everywhere. There is only one term for the Universe, and not two, this single term Consciousness, that manifests itself in two modes: Consciousness in Form, Consciousness Formless. And so, here is a sketch of what this new term Consciousness really means. For four great aspects of the real, four new cornerstones for a whole new civilization on Earth, based on Love and Truth. A. For the Universe: New causalities, all matter is an expression of Consciousness, awake and aware, Enspirited throughout, which has a place for the causalities of love ideas intent plan and purpose, what Aristotle called final causality, that for the sake of which. And it has a place for subjectivity, the greatest mystery in the whole of the Universe, knowable only in ourselves, but there in everything else as well, bedrock in the chain of causalities. The buck stops here. Here are two very different Universe pictures. The Cartesian Universe consists of things, pushed, and pulled around by the physical forces that function blind. The true Universe consists of selves and not things. Selves at least in ourselves, are organized and focused about an I, an I am, or a sense of self in everything, ever other being dear to itself. Just one aspect of subjectivity. And so, it is Consciousness all the way down, and subjectivity all the way down. Science proceeds on the basis of the negligible of what it can leave out as unimportant. Subjectivity is the ultimate animating principle of the Universe. What Descartes really did was to strip from nature what is most essential about it, its animating principle Consciousness. And so, we come out of a long history of “clunk.” The great male thinkers have killed creation. First in concepts and now in the lived life. And so, after centuries of fruitless search, not all of it in vain, finally, and just in time the true basic principle for the Universe has shown up in virtually all disciplines, this term Consciousness. B. And so, the Earth: What does this term Consciousness really mean for the Earth? It means that all of the bright array of beings around us have Consciousness. And the more we can realize how like us they are, the harder it will be to do them all in. Is this what it really means to be “made in the image of Spirit?” To destroy ever other living being? The god of Genesis is a creator god who has created billions and billions of living forms. Man, taking himself to be made in the image of Spirit has destroyed virtually all of it. The Earth is not things, not commodities and resources, not an endless array of consumer goods. The Earth consists of conscious living spiritual beings like ourselves, who need to be honored and respected, nurtured and cared for, to be Loved. And if the human race can finally pull it off and bring Love here and start helping the Earth rather than destroying her, even our vast numbers now at 8 billion, may not matter. Deeply embedded in the modern world is a false cosmology based on the hitherto useful but ultimately false metaphysics of Descartes. In particular it owes to Descartes concepts of matter, and of the Earth, as something devoid of Consciousness. And now this concept is up for us. If there is a single idea enabling and driving the destruction of the planet, it is the conviction that the Earth is something devoid of Consciousness. And we all have a vested interest in keeping this false concept in place. When you intend to ravage and savage the Earth, to turn it into consumer items, and money in the bank, first pretend she has no Consciousness that way we need not have any conscious about it. We are in deep trouble with the planet. Virtually all human economies are based on the destruction of the Earth, and we are now at a place in our history where we can foresee if we continue on as we are, our own extinction. And so, here are a few new guiding principles for the planet, based on Consciousness. Consciousness has field properties. The Earth is Consciousness throughout, connected and interconnected throughout, intersecting and interacting fields of Consciousness of which our own is one. To harm one is to harm all. Only this understanding of the Earth can set our destructive technologies, and capitalism, their goals, and their limits. The real problem with capitalism, and with civilization itself is it has no true understanding of the Earth, all the exquisite networks and webworks that connect all beings with one another. Nor it is about to admit that the Earth is our “life support system,” reason gone insane in the modern world. We are destroying our life support system, capitalism is the full expression of the human death wish in the modern world, and it needs to change. And now, let the barriers between ourselves and all other beings go down. C. And so, Ourselves. This new Universe picture based on Consciousness opens into and has a place for new concepts of human identity. In particular, it has a place for reincarnation, a process whereby one Consciousness dons’ bodies again and again and lays them down. This is a process wholly impossible on materialistic theories. This new view of things puts a higher perspective on Freudian determinism, which is a partial knowing in a greater account. We are something more than the victims of genes drives and childhood. We are immortally eternal evolving spiritual beings who take on a cycle of earthly lives in order to achieve certain goals and abilities, and then, our earthly cycle complete, we depart the Earth plane for other areas of the Universe physical or purely spiritual, to continue our evolution elsewhere. The scientific evidence for reincarnation is increasing on all sides, see for example the work of Michael Newton, a mainstream scientist forced to confront the fact of reincarnation. A completely new reincarnational picture is now emerging everywhere. We choose our parents for abilities we could acquire through them. We all come here with reasons for being here, and we all have free will, an original property of Consciousness, and we work out our issues accordingly. We all come here with the same reason for being here. It is to experience the Earth plane and human society at all levels and depths, in every social role, every climate, both sexes male and female and in all races. We are all here to acquire a deep understanding of the Earth plane with all its challenges and all of its present problems. We are not here to devour and consume the Earth, but to honor her for the learning experience she makes available for us. And so, reincarnation is the great equalizer, the fundamental basis for any bill of rights. Many of the problems of the modern world owe to the fact that reincarnation has not been taught in the West. Reincarnation was the center piece of Jesus teachings. It was banned by a fourth century council that decided the populous could best be controlled through fear. They edited all mention of reincarnation from the scriptures, and inserted fear terms instead, a judgmental god, and so on. If reincarnation had been taught, there would have been no suppression of women, but the gift of both sexes would have been honored and developed. And there would have been no reason for contempt for people of color because who they are, we have been or will be. There is no reason to look down on anyone when we know that our own identity includes membership in theirs. The truth of reincarnation needs to be the foundation for getting ourselves right with the Earth, and with one another. D. And so, Spirit. This new Universe picture, based on Consciousness, has a place for Spirit as simply Infinite Consciousness. All universes all worlds are formed out of this Consciousness, divine and sacred throughout. And Spirit is everywhere in the Earth and can be connected everywhere. And the Native North American people had things right. Everything has its own Spirit, and without contradiction is also an expression of Spirit. And what I am really doing in terms of concepts of modern science is presenting the Native North American version of the Real. And this new Universe picture has a place for the essential insight of all religions almost smothered by church tradition: Love. Not an emotion but a great Oneness, that can be found everywhere, even in a busy city street. But especially in the Earth, that is levels and depths of Oneness everywhere. And so, for the first time in their long and bitter antagonistic history, science and religion now share a common base with this term Spirit, the lynchpin in a new conceptual framework. And I offer an interpretation of where we are in our history, this present moment of historical grace, and these tumultuous times in which we live, the return of the Goddess and the Divine Feminine, the Reappearance of the Feminine in history, the Advent of Women, this great Awakening, as of Springtime after a long dark Winter, the Awakening, the Second Coming. And so, stay tuned! (shrink)

Solving Typhoon Turbulence Using the Universal Formula -/- By Angelito Malicse -/- Introduction -/- Typhoons are among the most destructive natural phenomena, bringing extreme winds, heavy rainfall, and turbulent ocean currents. The chaotic turbulence within a typhoon makes it difficult to predict and control, causing widespread devastation to coastal regions, infrastructure, and human lives. Despite advancements in meteorology and fluid dynamics, the turbulence inside typhoons remains a challenge for accurate forecasting and disaster mitigation. -/- By applying my universal formula, (...) class='Hi'>based on three fundamental laws of nature, we can develop a structured and effective approach to understanding and controlling typhoon turbulence. This essay explores how the Law of Karma (causality and system integrity), the Law of Balance in Nature, and the Law of Feedback Regulation provide the ultimate solution to typhoon turbulence. -/- Understanding Typhoon Turbulence Using the Universal Formula -/- Typhoons form due to energy imbalances in the atmosphere and ocean, driven by heat, pressure differences, and moisture content. The chaotic turbulence inside a typhoon is the result of: -/- 1. Unstable air currents caused by pressure and temperature gradients. -/- 2. Vortex formation driven by Earth’s rotation and wind shear. -/- 3. Excess energy accumulation in warm ocean waters. -/- By examining typhoon turbulence through the three universal laws, we can develop a scientific strategy to predict, weaken, and potentially neutralize typhoons before they cause destruction. -/- 1. The Law of Karma: Cause, Effect, and Systemic Integrity -/- The Law of Karma states that every effect has a cause, and for a system to function properly, it must be free of defects. A typhoon is an effect caused by imbalances in atmospheric and oceanic conditions. If these imbalances are corrected, typhoon turbulence can be weakened or prevented. -/- Applying the Law of Karma to Typhoon Control -/- ✅ Eliminate the root cause: Typhoons are fueled by warm ocean waters. Artificial cooling methods, such as cloud seeding or deep-sea upwelling (bringing cold water to the surface), could reduce the heat energy supply and prevent typhoon formation. -/- ✅ Detect turbulence before it intensifies: AI-driven weather models can predict early-stage typhoon turbulence and allow preemptive interventions. AI can identify defective atmospheric conditions (such as extreme heat buildup in ocean currents) and trigger mitigation efforts. -/- ✅ Disrupt vortex formation: Since typhoons rely on rotational forces, deploying strategically placed atmospheric pressure disturbances (via drones or cloud-seeding techniques) could disrupt the vortex before it gains full strength. -/- By identifying and neutralizing the causes of typhoon turbulence, we ensure that the system remains balanced, preventing large-scale destruction. -/- 2. The Law of Balance in Nature -/- The Law of Balance states that all systems naturally seek equilibrium. When a typhoon forms, it represents an extreme imbalance in the Earth’s energy system—excess heat and moisture create an unstable feedback loop of wind and turbulence. -/- Restoring Balance to Weaken Typhoon Turbulence -/- ✅ Regulating ocean surface temperature: Large-scale ocean-based temperature regulation systems (such as reflective films or artificial cooling platforms) can prevent typhoon formation by reducing the excess heat energy that fuels storms. -/- ✅ Breaking the pressure imbalance: Typhoons depend on a low-pressure core that intensifies wind speeds. By artificially increasing local air pressure using ionization or controlled cloud seeding, the extreme wind turbulence can be diffused before it reaches destructive levels. -/- ✅ Balancing atmospheric moisture: AI-assisted weather control could help regulate humidity levels through strategic rainfall induction in high-risk areas, ensuring that water vapor does not accumulate excessively to fuel a typhoon. -/- Since all systems follow natural equilibrium, strategically rebalancing temperature, pressure, and humidity will neutralize extreme typhoon turbulence. -/- 3. The Law of Feedback Regulation -/- The Law of Feedback Regulation states that all systems operate through feedback loops, where continuous monitoring and adjustment are necessary for stability. Typhoon turbulence follows feedback patterns, which means it can be tracked, analyzed, and counteracted using real-time data. -/- Developing an AI-Driven Typhoon Suppression System -/- ✅ AI-powered real-time monitoring: Advanced satellites, ocean buoys, and drones can provide instant feedback on typhoon development, allowing for proactive interventions rather than reactive disaster response. -/- ✅ Adaptive wind and pressure control: Deploying AI-controlled drones or weather balloons to release cooling agents, modify air pressure, or disperse cloud formations could interrupt the storm's feedback loop, reducing its intensity. -/- ✅ AI-driven weather forecasting for early response: Using deep learning algorithms, AI can accurately predict turbulence patterns weeks in advance, allowing governments to take preventive action instead of just preparing for disaster relief. -/- By implementing real-time monitoring and intervention, we can use feedback regulation to weaken or redirect typhoons before they cause catastrophic damage. -/- The Future of Typhoon Control with the Universal Formula -/- By integrating my universal formula into meteorology and disaster prevention, we can develop a comprehensive AI-driven typhoon suppression system that follows the three fundamental laws of nature: -/- 1. Law of Karma (Causality and Systemic Integrity): Address the root causes of typhoon formation by eliminating atmospheric and oceanic imbalances. -/- 2. Law of Balance in Nature: Restore equilibrium by regulating ocean temperatures, air pressure, and humidity. -/- 3. Law of Feedback Regulation: Use AI-driven real-time monitoring and intervention to weaken or prevent typhoons. -/- Through advanced AI, environmental engineering, and a deep understanding of nature’s laws, we can move beyond simply predicting typhoons and start actively controlling their development. -/- Conclusion -/- Typhoon turbulence, long considered an unpredictable force of nature, is fundamentally a problem of imbalance, energy accumulation, and feedback-driven intensification. By applying my universal formula, we can shift from passive disaster response to active typhoon control, using AI, environmental intervention, and natural equilibrium principles to prevent devastation. -/- This solution is not just theoretical—it aligns with the fundamental laws governing all natural systems. Once implemented, it will mark the beginning of a new era where humanity can harness nature’s own principles to create balance, stability, and protection from extreme weather. -/- . (shrink)

A Balanced Economic Model: The Feedback Loop Between Public and Private Sectors with MMT as a Stabilizing Mechanism -/- Introduction -/- Modern capitalism thrives on competition, profit motives, and consumer demand. However, the system is flawed because it allows extreme wealth inequality, market instability, and frequent economic crashes. Advertising, as an essential part of capitalism, manipulates consumer behavior to sustain profits. While this fuels economic growth, it also distorts the real needs of society. -/- A better alternative Is a (...) hybrid economic model where government-created jobs, social safety nets, and free public services coexist with a profit-driven private sector. The key to making this work is a feedback loop mechanism that keeps the two sectors balanced, ensuring economic stability while preventing extreme inequality and unnecessary market collapses. This essay explores how Modern Monetary Theory (MMT) can support this feedback loop economy to create a self-regulating system where both public and private sectors benefit from each other. -/- I. The Feedback Loop Between Private Companies and Government Economic Policies -/- A feedback loop mechanism is a self-regulating system where different components interact, adjust, and respond to maintain balance. In the economy, the public sector (government jobs, social safety nets, and public services) and the private sector (businesses, investments, and free markets) create a mutual dependency: -/- 1. Government Spending Creates Consumer Demand → Private Sector Growth -/- Government creates jobs with good salaries in infrastructure, education, healthcare, and technology. -/- This injects money into the economy, giving people the purchasing power to buy goods and services from private companies. -/- As demand increases, businesses grow, hire more workers, and expand operations. -/- 2. Private Sector Growth → Increases Government Revenue Without High Taxation -/- As private companies generate profits, they pay taxes and reinvest in expansion. -/- Strong consumer demand reduces the need for excessive taxation because economic growth itself funds public programs. -/- Businesses compete not only for profits but also for innovation and efficiency. -/- 3. Social Safety Nets Prevent Market Collapses -/- During recessions, government stabilizes the economy by expanding social programs (unemployment benefits, food assistance, healthcare). -/- This prevents demand from crashing, ensuring that businesses still have customers even in economic downturns. -/- As the economy recovers, government reduces spending, allowing the private sector to take the lead again. -/- This dynamic cycle ensures that economic booms and recessions are smoothed out, preventing extreme market crashes or mass unemployment. -/- II. The Role of MMT in Supporting the Feedback Loop -/- Modern Monetary Theory (MMT) provides the economic foundation for this model by proving that a sovereign government can spend money without being constrained by traditional budget rules. Unlike mainstream economic thinking, which suggests that governments must “balance the budget,” MMT argues that government spending should adjust based on economic conditions. -/- 1. Government-Backed Job Programs as an Economic Stabilizer -/- MMT allows governments to fund public jobs without relying solely on taxation. -/- If private companies cut jobs, the government can expand its workforce to absorb the unemployed. -/- When the economy stabilizes, people move back to higher-paying private jobs, reducing government spending. -/- 2. Preventing Inflation Through Resource Control -/- MMT acknowledges that inflation happens when there’s too much money chasing too few goods. -/- The government can remove excess money through targeted taxation and invest in productivity (e.g., infrastructure, education) to keep supply stable. -/- This prevents excessive inflation while keeping the economy growing. -/- 3. Continuous Money Circulation Without Debt Crises -/- Governments can print money to fund essential services, but they control inflation by investing in real production capacity (e.g., factories, renewable energy, technology). -/- This means public investment directly benefits private businesses, keeping both sectors in sync. -/- This MMT-backed feedback loop ensures that economic downturns do not lead to catastrophic business failures or mass unemployment. -/- III. The Role of Advertising in a Balanced Economic System -/- Advertising, while necessary for businesses, often manipulates consumer behavior in a way that creates artificial demand. In a feedback loop economy, advertising should be regulated to align with real consumer needs rather than exploiting psychological weaknesses. -/- 1. Ethical Advertising Policies -/- Companies should be incentivized to market based on quality and innovation rather than manipulation. -/- False advertising and monopolistic dominance should be regulated to prevent consumer exploitation. -/- 2. Consumer Education Programs -/- Public education should include critical thinking courses to help people make informed purchasing decisions. -/- This reduces the influence of manipulative advertising, ensuring that businesses compete fairly. -/- This ensures that the feedback loop remains healthy, preventing unnecessary overproduction and unsustainable consumer debt. -/- IV. Real-World Examples of a Balanced System -/- Some countries have successfully implemented elements of this feedback loop economic model: -/- Nordic Countries (Sweden, Norway, Denmark, Finland) -/- Have free healthcare, education, and social safety nets while maintaining a competitive private sector. -/- Use progressive taxation to prevent extreme inequality, ensuring that economic growth benefits everyone. -/- Germany -/- Uses government-backed vocational training programs to ensure a highly skilled workforce. -/- Strong public-private partnerships help both sectors support each other dynamically. -/- Japan -/- Government plays a major role in funding research, infrastructure, and innovation, allowing private businesses to thrive. -/- Uses state-owned enterprises strategically while ensuring a competitive private market. -/- These examples prove that a properly managed hybrid model is more resilient, fair, and stable than extreme capitalism or extreme socialism. -/- V. Conclusion: A Self-Regulating Economy for the Future -/- A feedback loop economic system provides the best of both worlds: ✔ Government ensures economic stability through public job creation and social safety nets. ✔ Private companies drive innovation and competitiveness with strong consumer demand. ✔ MMT allows government spending to adjust dynamically without unnecessary austerity measures. ✔ Advertising is reformed to encourage ethical business practices and informed consumer choices. ✔ Inflation is controlled through taxation, investment, and resource management. -/- By integrating these feedback loop mechanisms, we can create a self-regulating economic model where both public and private sectors reinforce each other, ensuring long-term stability, prosperity, and economic fairness. -/- Policy Framework for a Balanced Economic System: Global Best Practices -/- To fully integrate the feedback loop mechanism between the public and private sectors, specific policies must be implemented to ensure economic stability, innovation, and fairness. Below are real-world policy examples that demonstrate how different countries successfully manage their economies using a mix of government intervention and free market principles. -/- I. Public Job Creation as an Economic Stabilizer -/- One of the biggest issues in capitalism is economic recessions leading to mass layoffs, which then reduce consumer spending, creating a vicious cycle of economic decline. The solution is public sector job programs that absorb unemployed workers during downturns and allow them to transition back to private jobs when the economy improves. -/- Global Examples -/- ✔ United States (New Deal Programs – 1930s) -/- During the Great Depression, the U.S. government created millions of jobs in construction, public works, and conservation projects. -/- These projects boosted infrastructure while providing employment, helping to revive the economy. -/- ✔ Argentina’s Jefes de Hogar Program (2002-2006) -/- Aimed at mitigating mass unemployment during Argentina’s economic crisis. -/- The government hired unemployed citizens to work in community service, infrastructure, and public health projects. -/- Created social stability and demand for private goods, helping Argentina recover. -/- ✔ Germany’s Kurzarbeit Program (Ongoing) -/- In times of economic slowdown, the German government pays companies to keep workers employed at reduced hours rather than laying them off. -/- This prevents mass unemployment, ensuring that workers still have income and spending power. -/- Policy Recommendation: → Implement automatic public employment programs during recessions to keep demand stable and prevent economic crashes. -/- II. Social Safety Nets to Support Consumer Demand -/- A strong social safety net ensures that consumers have purchasing power even in economic downturns, keeping the private sector stable. -/- Global Examples -/- ✔ Nordic Model (Denmark, Sweden, Norway, Finland) -/- Provides free healthcare, education, and unemployment benefits, preventing extreme poverty. -/- Funded through progressive taxation, ensuring that the wealthy contribute fairly to society. -/- This creates a stable consumer base for private companies, benefiting the entire economy. -/- ✔ Universal Basic Income (UBI) Experiments (Finland, Canada, Kenya) -/- Finland tested a UBI program where unemployed citizens received a monthly payment regardless of employment status. -/- Results showed that recipients were more likely to start businesses and find better jobs, proving that social safety nets do not reduce work incentives. -/- ✔ Singapore’s Housing and Retirement System -/- The government helps citizens buy homes with public funds, ensuring stable housing. -/- A mandatory retirement savings system (Central Provident Fund) ensures that people have money after they retire. -/- These policies reduce financial anxiety, allowing people to focus on entrepreneurship and economic growth. -/- Policy Recommendation: → Implement universal healthcare, free education, and unemployment benefits to ensure that economic downturns do not collapse consumer spending. -/- III. Regulating Advertising to Align with Consumer Needs -/- Unregulated advertising manipulates consumer behavior, creating unnecessary demand and overconsumption, which destabilizes economies. Governments can regulate advertising to ensure ethical business practices. -/- Global Examples -/- ✔ European Union (Strict Advertising Laws) -/- The EU bans false advertising, ensuring that companies cannot make misleading claims about their products. -/- Certain junk food and alcohol ads are restricted to protect public health. -/- ✔ France’s Ban on Child-Targeted Advertising -/- Prevents unethical marketing towards children, reducing unnecessary consumerism. -/- ✔ Japan’s Culture of Product Quality Over Hype -/- Japanese companies emphasize product reliability and long-term value, reducing dependence on manipulative advertising. -/- Policy Recommendation: → Implement ethical advertising regulations to prevent false marketing, predatory ads targeting vulnerable consumers, and excessive consumer debt. -/- IV. Public-Private Partnerships for Innovation and Infrastructure -/- Rather than treating the government and private sector as separate entities, a well-balanced system interconnects them through public-private partnerships (PPPs) to drive innovation. -/- Global Examples -/- ✔ Germany’s Mittelstand Model (SME Support System) -/- The German government provides long-term financial support to small and medium-sized enterprises (SMEs), which are the backbone of the economy. -/- Ensures that private businesses have stable growth without excessive corporate monopolies. -/- ✔ China’s State-Led Economic Model (Strategic Government Investments) -/- The government invests heavily in infrastructure and technology, allowing private businesses to thrive with low-cost logistics and energy. -/- Balances capitalist competition with government support, ensuring stability. -/- ✔ United States (NASA & SpaceX Collaboration) -/- NASA funded SpaceX and other private space companies, leading to rapid innovation in space technology. -/- This proves that government funding can accelerate private sector breakthroughs. -/- Policy Recommendation: → Use government funding to support innovation and long-term infrastructure projects while allowing private businesses to benefit and expand. -/- V. MMT as a Tool for Economic Stability -/- Traditional economic models suggest that governments must “balance their budgets” like households, but this is a flawed concept. Modern Monetary Theory (MMT) argues that sovereign nations with their own currency (like the U.S., Japan, and the UK) can create money to fund essential services without relying on debt from private banks. -/- How MMT Works in Practice -/- ✔ Japan’s National Debt Strategy -/- Japan has one of the highest debt-to-GDP ratios in the world, yet it has no financial crisis because it borrows in its own currency. -/- Instead of austerity, Japan uses public investment to maintain economic stability. -/- ✔ U.S. Stimulus During COVID-19 -/- The U.S. government printed money to send direct payments to citizens, preventing a total economic collapse. -/- Inflation was controlled by adjusting taxation and investment in production capacity. -/- ✔ EU’s Post-COVID Recovery Fund -/- The European Union used public money to stabilize industries and workers, preventing extreme recessions. -/- Policy Recommendation: → Use MMT-based strategies to fund infrastructure, social programs, and innovation, ensuring economic stability without excessive reliance on private banking debt. -/- VI. Conclusion: Creating a Self-Regulating Economy -/- A feedback loop economy that integrates public job creation, private sector competition, social safety nets, and MMT-backed fiscal policies provides a self-regulating system that ensures: -/- ✔ Stable employment and consumer demand even during economic downturns. ✔ Innovation and competition in the private sector without excessive monopolies or market crashes. ✔ Government-funded infrastructure and social programs that benefit both workers and businesses. ✔ Ethical advertising that prevents consumer exploitation and unnecessary debt. ✔ Balanced inflation control through strategic taxation and investment. -/- By combining the best policies from different global models, we can build an economic system that minimizes business bankruptcies, prevents recessions, and maximizes innovation and economic fairness. -/- . (shrink)

Symmetry, Symmetry Violation, and the Universal Formula of Free Will -/- Introduction -/- Symmetry is a fundamental principle in physics, representing balance, order, and predictability. It is seen in nature, from the structure of atoms to the large-scale organization of the universe. However, perfect symmetry is rarely observed In reality. Instead, the breaking of symmetry plays a crucial role in shaping the physical world, from the Higgs mechanism that gives particles mass to the dominance of matter over antimatter in the (...) universe. -/- Similarly, human decision-making—if governed by natural laws—may also follow a structured yet dynamic pattern influenced by symmetry and its violations. This essay explores how the concept of symmetry violation in physics relates to free will, decision-making, and societal development, particularly in the context of Angelito Malicse’s universal formula, which proposes that all human behavior follows natural laws, specifically the universal law of balance in nature. -/- Symmetry and Symmetry Breaking in Physics -/- In physics, symmetry is an organizing principle that governs the laws of nature. It ensures that physical processes behave predictably under transformations such as time reversal, spatial inversion, or charge conjugation. However, symmetry is often spontaneously or explicitly broken, leading to the formation of complex structures and behaviors. -/- Examples include: -/- The Higgs Mechanism: The universe began with a symmetrical state, but as it cooled, the Higgs field broke symmetry, giving mass to particles. -/- CP Violation: In particle physics, the violation of charge-parity (CP) symmetry explains why matter dominates over antimatter, allowing the universe as we know it to exist. -/- Time-Reversal Violation: Some physical processes prefer a particular direction of time, reinforcing the concept of an arrow of time where events cannot be reversed. -/- These symmetry violations are not random but occur within a structured framework that directs the evolution of physical systems. -/- The Feedback Mechanism Between Symmetry Violation and Free Will -/- Angelito Malicse’s universal formula suggests that human decision-making follows natural feedback mechanisms, shaping both individual and collective behavior. This idea parallels how symmetry breaking in physics is not chaotic but structured, influencing the evolution of systems over time. -/- The Universe’s Asymmetry and Free Will: Just as the universe had an initial symmetry that was broken to create order, human consciousness might start with a natural state of balance that is continuously reshaped by feedback from external and internal forces. -/- Feedback in Decision-Making: Choices are not purely deterministic (fixed by initial conditions) nor entirely random (free of constraints). Instead, decisions create irreversible consequences, much like symmetry violations that shape the universe permanently. -/- Example in Leadership: A government’s policies shape societal outcomes in an irreversible way, just as CP violation permanently influenced the universe’s composition. Leaders must understand that their decisions follow natural laws and should strive to maintain balance while allowing necessary asymmetry. -/- Thus, free will is not an absolute freedom to choose anything at random but rather a structured process where each decision modifies future possibilities, similar to how symmetry breaking directs the universe’s evolution. -/- The Arrow of Time and the Evolution of Consciousness -/- One of the most striking parallels between symmetry violation and human decision-making is the irreversibility of choices. In physics, the violation of time symmetry ensures that events unfold in one direction, making it impossible to return to a prior state. This concept applies to: -/- Thermodynamics (Entropy Always Increases): Disorder naturally grows over time, making reversibility impossible in most cases. -/- Human Thought and Societal Change: Each decision reshapes an individual’s future and influences society’s direction. Just as the universe cannot return to a perfectly symmetrical state, a mind shaped by past experiences cannot return to an earlier state of pure neutrality. -/- Educational and Political Implications: Education should account for the irreversible nature of learning—once individuals internalize knowledge, they do not simply return to ignorance. Similarly, societies evolve based on past choices, and policies must consider long-term irreversible consequences. -/- This aligns with the universal formula’s principle that decision-making is structured by natural laws and follows a continuous feedback cycle rather than being arbitrary or disconnected. -/- Symmetry Breaking and the Limits of Absolute Free Will -/- Malicse’s universal formula suggests that free will is governed by natural laws, meaning it is neither purely deterministic nor entirely free. This aligns with how symmetry breaking in physics does not eliminate structure but rather creates new frameworks for order. -/- Free Will as Guided Asymmetry: If decision-making is subject to feedback mechanisms and natural constraints, it is not a random, unconstrained process. Instead, it follows a pattern where certain choices become more probable based on prior conditions. -/- Homeostasis as Controlled Symmetry Breaking: Biological and cognitive systems self-regulate through controlled asymmetry—maintaining balance while allowing necessary adjustments. A perfectly symmetrical system would be static and unresponsive, whereas a controlled level of asymmetry enables adaptability. -/- Ethical and Social Considerations: Since decision-making follows natural principles, governance, education, and AI should be designed to optimize balance while allowing for necessary deviations. Unregulated decision-making would be as chaotic as an unbalanced physical system. -/- Applying These Principles to Education, Leadership, and AI -/- If human decision-making follows the same structured asymmetry found in physics, then institutions should be designed accordingly. -/- Education and Cognitive Development: Traditional education assumes equal potential for all students, but in reality, each mind develops asymmetrically based on prior feedback mechanisms. A better system would adapt to individual asymmetries rather than enforcing rigid uniformity. -/- Leadership and Policy-Making: Leaders should recognize that decisions create irreversible changes—just as symmetry breaking in physics determines the universe’s evolution. Policies must be structured to maintain balance while allowing controlled flexibility. -/- AI and Decision Systems: Future AI could be designed using natural feedback principles from physics and human cognition, ensuring that decision-making processes follow the universal law of balance in nature rather than purely statistical or rule-based logic. -/- Conclusion -/- The parallels between symmetry violation in physics and the nature of free will suggest that decision-making follows structured laws rather than being entirely free or deterministic. Just as symmetry breaking in the universe creates order and direction, human choices are shaped by feedback loops, prior conditions, and the natural tendency toward balance with necessary asymmetries. -/- Angelito Malicse’s universal formula aligns with these principles, emphasizing that all human behavior follows natural laws. If this understanding is properly integrated into education, governance, and AI, it could create a more balanced and sustainable societal framework—one that acknowledges both the necessity of order and the inevitability of controlled asymmetry. -/- . (shrink)

Background: how mind functions is subject to continuing scientific discussion. A simplistic approach says that, since no convincing way has been found to model subjective experience, mind cannot exist. A second holds that, since mind cannot be described by classical physics, it must be described by quantum physics. Another perspective concerns mind's hypothesized ability to interact with the world of quanta: it should be responsible for reduction of quantum wave packets; physics producing 'Objective Reduction' is postulated to form the basis (...) for mind-matter interactions. This presentation describes results derived from a new approach to these problems. It is based on well-established biology involving physics not previously applied to the fields of mind, or consciousness studies, that of critical feedback instability. -/- Methods: 'self-organized criticality' in complexity biology places system loci of control at critical instabilities, physical properties of which, including information properties, are presented. Their elucidation shows that they can model hitherto unexplained properties of experience. -/- Results: All results depend on physical properties of critical instabilities. First, at least one feed-back or feed-forward loop must have feedback gain, g = 1: information flows round the loop impress perfect images of system states back on themselves: they represent processes of perfect self-observation. This annihilates system quanta: system excitations are instability fluctuations, which cannot be quantized. Major results follow: -/- 1. Information vectors representing criticality states must include at least one attached information loop denoting self-observation. -/- 2. Such loop structures are attributed a function, 'registering the state's own existence', explaining -/- a. Subjective 'awareness of one's own presence' -/- b. How content-free states of awareness can be remembered (Jon Shear) -/- c. Subjective experience of time duration (Immanuel Kant) -/- d. The 'witness' property of experience – often mentioned by athletes 'in the zone' -/- e. The natural association between consciousness and intelligence -/- This novel, physically and biologically sound approach seems to satisfactorily model subjectivity. -/- Further significant results follow: -/- 1. Registration of external information in excited states of systems at criticality reduces external wave-packets: the new model exhibits 'Objective Reduction' of wave packets. -/- 2. High internal coherence (postulated by Domash & Penrose) leading to a. Non-separable information vector bundles. b. Non-reductive states (Chalmers's criterion for experience). -/- 3. Information that is: a. encoded in coherence negentropy; b. non-digitizable, and therefore c. computationally without digital equivalent (posited by Penrose). -/- Discussion and Conclusions: instability physics implies anharmonic motion, preventing excitation quantization, and totally different from the quantum physics of simple harmonic motion at stability. Instability excitations are different from anything hitherto conceived in information science. They can model aspects of mind never previously treated, including genuine subjectivity, objective reduction of wave-packets, and inter alia all properties given above. (shrink)

The God Experiment – Let there be Light -/- The question “What is real?” can be traced back to the shadows in Plato’s cave. Two thousand years later, Rene Descartes lacked knowledge about arguing against an evil´ deceiver feeding us the illusion of sensation. Descartes’ epistemological concept later led to various theories of what our sensory experiences actually are. The concept of ”illusionism”, proposing that even the very conscious experience we have – our qualia – is an illusion, is not (...) only a red-pill scenario found in the 1999 science fiction movie ”The Matrix” but is also a philosophical concept promoted by modern tinkers, most prominently by Daniel Dennett. He describes his argument against qualia as materialistic and scientific. Reflection upon a possible simulation and our perceived reality was beautifully visualized in “The Matrix”, bringing the old ideas of Descartes to coffee houses around the world. Irish philosopher Bishop Berkeley was the father of what has later been coined as “subjective idealism”, basically stating that “what you perceive is real” (e.g., ”The Matrix” is real because its population perceives it). Berkeley then argued against Isaac Newton’s absolutism of space, time, and motion in 1721, ultimately leading to Ernst Mach and Albert Einstein’s respective views. Several neuroscientists have rejected Dennetts’ perspective on the illusion of consciousness, and idealism is often dismissed as the notion that people want to pick and choose the tenets of reality. Even Einstein ended his life on a philosophical note, pondering the very foundations of reality. With the advent of quantum technologies based on the control of individual fundamental particles, the question of whether our universe is a simulation isn’t just intriguing. Our ever-advancing understanding of fundamental physical processes will likely lead us to build quantum computers utilizing quantum effects for simulating nature quantum-mechanically in all complexity, as famously envisioned by Richard Feynman. Finding an answer to the simulation question will potentially alter our very definition and understanding of life, reshape theories on the evolution and fate of the universe, and impact theology. No direct observations provide evidence in favor or against the simulation hypothesis, and experiments are needed to verify or refute it. In this paper, we outline several constraints on the limits of computability and predictability in/of the universe, which we then use to design experiments allowing for first conclusions as to whether we participate in a simulation chain. We elaborate on how the currently understood laws of physics in both complete and small-scale universe simulations prevent us from making predictions relating to the future states of a universe, as well as how every physically accurate simulation will increase in complexity and exhaust computational resources as global thermodynamic entropy increases. Eventually, in a simulation in which the computer simulating a universe is governed by the same physical laws as the simulation and is smaller than the universe it simulates, the exhaustion of computational resources will halt all simulations down the simulation chain unless an external programmer intervenes or isn’t limited by the simulation’s physical laws, which we may be able to observe. By creating a simulation chain and observing the evolution of simulation behavior throughout the hierarchy taking stock of statistical relevance, as well as comparing various least complex simulations under computability and predictability constraints, we can gain insight into whether our universe is part of a simulation chain. -/- Index Terms—Simulation, simulation hypothesis, quantum computing, universe, life, intelligence. (shrink)

Understanding the policymaking process in an emerging economy in the global south, such as Bangladesh, holds significant importance. The country's remarkable socio-economic development, once the most impoverished in the region, has been facilitated by post-globalization economic transformation. While the literature on institutional change has predominantly focused on states in industrialist countries, this dissertation presents an innovative theoretical approach. It deeply explores primary case materials to illustrate how the state engages in policy evolution in a developing country's gradual shift from (...) the import substitution model towards globalization and deregulation. The central argument posited is that Bangladesh's globalization, particularly through its private sector-led garment exports, stands as a significant success story. Bangladesh is now the world's second-largest garment exporter after China. This achievement is attributed to the entrepreneurial development it fosters and its role in driving socio-economic change. Moreover, it has enabled the mobilization of resources, reducing aid dependence, enhancing climate resilience, improving public health and wellbeing, empowering women, and addressing critical needs in physical infrastructure and human development. The argument presented here diverges from the conventional explanation found in the literature, which tends to emphasize the role of external forces, particularly institutions like the World Bank, the International Monetary Fund, and donors, in triggering policy reforms in Bangladesh. These reforms, commonly linked with structural adjustment packages implemented during the balance of payments crisis, are frequently perceived as predominantly influenced by external pressures. Additionally, the influence of the business class or Bangladeshi non-governmental organizations (NGOs) is often asserted. This dissertation proposes an alternative explanation by suggesting that ideational viewpoints within the state, specifically the ideas espoused by top technocrats and political executives, played a significant role. It argues that these internal ideational factors were more influential than materialistic ones, highlighting the causal role of the policy process driven by endogenous imperatives. The introduction of the dissertation addresses the research problem and research puzzle while suggesting conjectures after problematizing existing arguments. The significant economic transformation observed in Bangladesh today is portrayed as the outcome of a gradual process spanning several decades. The transition towards promoting the private sector and embracing globalization commenced in 1991, following a series of incremental changes dating back to the 1970s and 1980s. During these periods, the institutional path progressed towards empowering the private sector and embracing globalization, laying the groundwork for a trajectory led by the private sector in the context of globalization. The theory chapter serves to establish the conceptual and theoretical foundation for analyzing both economic change and transformation by examining the evolutionary nature of the process. The study adopts an institutional change framework, drawing on the theory of gradual change and focusing on concepts such as layering and tipping points. Within this framework, causal variables such as powering and puzzling, social learning, and ideas are identified. The methodological approach is grounded in historical institutionalism, employing the process-tracing "within case" method. The selection of cases deliberately targets an important yet under-researched area—the policy process in Bangladesh concerning the success of garment-led industrialization. This dissertation fills a noticeable gap in the literature through rigorous analysis, enabling an in-depth exploration of the institutional dynamics spanning four governments from 1972 to 1991. The study relies on substantial primary materials, including interviews with key officials. Each empirical chapter not only presents data but also connects the findings to conceptual and theoretical conjectures, underscoring the significant contributions of this research. The key causal variables identified include the concepts of ‘puzzling’ and ‘social learning’ within the state capacity framework, along with a narrowly defined and developed concept of a "policy committee." The learning process entails technocrats engaging in what Hugh Heclo and Peter Hall term as "social learning," where they play a crucial role in addressing policy challenges, particularly during times of uncertainty and political turmoil, based on their learning from past experiences. Additionally, the concept of ‘powering’ is highlighted, emphasizing that while technocrats provide policy recommendations, it is ultimately the political executive who endorses policies. The interplay between ‘puzzling and powering’ and ‘social learning’ shapes the outcomes of the policy process. The first empirical chapter focusing on the Sheikh Mujibur Rahman Government (1972-1975) illustrates the emergence of policy learning during this period. Initially, this government pursued import substitution under strict government controls, with a predominant public sector. The historical context of exploitation under Pakistani rule and the centralization of industry by West Pakistan fostered socialism as an ideal for East Pakistan's economic emancipation. Additionally, close ties with India and the Soviet Union reinforced this socialist tendency. However, due to severe economic conditions resulting from stringent control on private investment and emphasis on large-scale public investment, policy puzzling and learning ensued. As a result, incremental changes were initiated, allowing limited private sector participation. The second empirical chapter explores the General Ziaur Rahman government's tenure (1975-1981) and how deregulation was consolidated within a layering step, paving the way for a shift towards globalization. General Zia and his technocrats, operating under authoritarian conditions, acknowledged the inefficacy of existing policies. Furthermore, General Zia's inclination towards the West fostered closer collaboration with donors. The Multifiber Agreement (MFA) presented an opportunity for garments, coinciding with the decline in jute exports. This government opened up industrial sectors for private participation, and banks provided funding across various sectors, with special emphasis on the burgeoning garment industry. The chapter also explores the origins of the garment industry during this period. Notably, Noorul Quader Khan, upon retiring as cabinet secretary, collaborated with a Korean multinational, Daewoo, with the support of General Zia, leading to the establishment of Desh Garments—a pioneering venture that catalyzed the export orientation of the sector. The third empirical chapter delves into the economic policies of the General Hussain Muhammad Ershad Government (1982-1990), highlighting its emphasis on greater private sector involvement. Under this administration, there was a political inclination towards globalization and deregulation, leading to the appointment of technocrats aligned with this vision. The leadership believed that promoting the private sector would be more effective in job creation. Despite facing significant political opposition, efforts towards disinvestment were made, eventually resulting in compromises like public-private partnerships. The decentralization of administration and restructuring of ministries aimed at promoting industrialization and economic globalization driven by the private sector at the regional level. Initiatives such as the Industrial Promotion and Development Company, with support from organizations like the International Finance Corporation, aimed to boost the private sector. Efforts towards globalization were synchronized with the establishment of an export processing zone in Chittagong, focusing on promoting private and foreign investment. Foreign investment promotion was encouraged through diplomatic efforts and legislative measures to safeguard investors. Currency devaluation was utilized to stimulate exports, along with some degree of import liberalization. The chapter convincingly argues that the groundwork for globalization, initiated under General Zia, came to fruition under General Ershad. The final empirical chapter contends that the system shifted towards globalization and deregulation in 1991. Although a severe balance of payments crisis occurred in 1989, it wasn't perceived as the sole cause of the industrial policy of 1991. The democratic uprising in 1990 led to the downfall of the military-backed government and the rise of a democratic government. The chapter argues that while economic and political changes may have been intertwined, the economic shift in 1991 was primarily driven by ideas within the state and driven by endogenous imperatives. It examines preceding periods to illustrate how the tipping mechanism might have operated, detailing the roles of top technocrats and political executives. The chapter provides insights into key policymakers and their ideas, as well as their interactions with industrialists, entrepreneurs, and representatives of multilateral organizations like the World Bank. Significant reform measures, including tariff reduction, the introduction of value-added tax, banking sector reform, and the adoption of floating exchange rates, are outcomes of the policy change. Additionally, sectors such as power, banks, and telecommunications, formerly monopolized by the public sector, are now deregulated. (shrink)

The current study is a pilot trial to examine the effects of a nonelective, classroom-based, teacher-implemented, mindfulness meditation intervention on standard clinical measures of mental health and affect in middle school children. A total of 101 healthy sixth-grade students (55 boys, 46 girls) were randomized to either an Asian history course with daily mindfulness meditation practice (intervention group) or an African history course with a matched experiential activity (active control group). Self-reported measures included the Youth Self Report (YSR), a (...) modified Spielberger State-Trait Anxiety Inventory, and the Cognitive and Affective Mindfulness Measure –Revised. Both groups decreased significantly on clinical syndrome subscales and affect but did not differ in the extent of their improvements. Meditators were significantly less likely to develop suicidal ideation or thoughts of self-harm than controls. These results suggest that mindfulness training may yield both unique and non-specific benefits that are shared by other novel activities. (shrink)

Background: Educated women tend to have a greater awareness of the existence of ANC services, more aware of health problems, know more about the availability of health care services, and utilize the information more effectively than non-educated women. Moreover, higher levels of education tend to positively affect healthseeking behaviors, and education may increase a woman’s control over her pregnancy and expose women to more health education messages and campaigns, enabling them to recognize danger signs and complications and take appropriate action. (...) In this study, we tried to analyze to what level the maternal education can influence the antenatal care services and childcare. Methods: A community-based cross-sectional study was conducted on 93 randomly selected mothers who have children less than 7 years by using a pre-tested structured questionnaire for data collection at various tribal villages, at an average 25 kms away from Adilabad town from April-October 2019. Analysis was done using SPSS for windows version 16, Microsoft excel and Open epi website. Results: Out of 93 study subjects, 19.3% (18) of the study subjects were not registered for the antenatal services. Higher the maternal education higher the age at pregnancy (p<0.05), was associated with more preference for deliveries by doctors (p<0.05). More the frequency of exclusive breast feeding, long lasting breast feeding was associated more than a year (p<0.05), a smaller number of children with wasting (p<0.05). Conclusion: This study revealed that utilization of ANC services was relatively better for the mother’s educated higher than secondary school, but they are still low. Educational status is important in having more health seeking behavior. In this study, it proves that health education is more important than the mere school education which can help to improve knowledge on ANC. (shrink)

The State of Nirvana Explained Through the Universal Formula -/- Nirvana, a concept often associated with Buddhism, represents a state of ultimate peace, liberation, and detachment from suffering. Traditionally, it is understood as the cessation of desires and the end of the cycle of birth and rebirth. However, using my universal formula, Nirvana can be understood more precisely as a state of perfect balance, where the system of human consciousness operates free from defects and external disturbances. By (...) examining Nirvana through the universal law of balance in nature, the law of karma as a system principle, and the feedback mechanism of conscious minds, we can explain it as the highest achievable state of homeostasis in human decision-making and awareness. -/- Nirvana as Perfect Balance in Nature -/- According to the universal law of balance in nature, all systems—whether they are physical, biological, or cognitive—must maintain equilibrium to function optimally. Any deviation from balance results in dysfunction, suffering, or destruction. In this context, the state of Nirvana is the ultimate form of equilibrium in the human mind, where all forms of psychological and emotional turbulence have been neutralized. -/- Human suffering often arises from internal imbalances caused by uncontrolled desires, false beliefs, and external influences. When a person reaches Nirvana, their mind no longer fluctuates between extremes such as attachment and aversion, pleasure and pain, or hope and fear. Instead, they attain a stable and self-regulating mental state that is in perfect harmony with the natural laws governing reality. -/- Karma and the System of Consciousness -/- The law of karma, as understood in my universal formula, does not merely refer to the traditional idea of moral cause and effect but extends to the principle of systems functioning without defects. Any system, whether mechanical, biological, or cognitive, must be free of errors to operate effectively. If an engine has faulty components, it will not run efficiently; if the human body accumulates toxins, it will suffer disease. Similarly, if the mind is filled with ignorance, false assumptions, or emotional disturbances, it will create suffering. -/- Nirvana, in this sense, is the final correction of the system of consciousness. It is a state where all mental defects—such as irrational fears, harmful attachments, and misperceptions—have been eliminated. The individual no longer reacts to external influences in a way that creates further imbalance or suffering. They achieve a fully optimized and self-sustaining mental state, free from unnecessary disturbances. -/- Is Nirvana a Permanent or Dynamic State? -/- From the perspective of the universal law of balance in nature, Nirvana is a dynamic state rather than a fixed or permanent one. No system in nature remains absolutely static; instead, it continuously adjusts to maintain balance in response to external and internal influences. Even though Nirvana is often described as the cessation of suffering, it does not mean the individual mind ceases to function or engage with reality. Rather, it reaches a level of self-correction and adaptability, where it can maintain balance despite changing conditions. -/- A person in Nirvana does not freeze in a single state but dynamically interacts with reality while ensuring that no imbalance disturbs their equilibrium. Just as homeostasis in the human body requires constant regulation to maintain stability, the state of Nirvana involves continuous awareness and adjustment to preserve its balance. Therefore, rather than being a fixed endpoint, Nirvana can be understood as a sustained and dynamic process of perfect self-regulation. -/- The Feedback Mechanism of Conscious Minds -/- Beyond the individual, all conscious beings exist in a collective feedback system, where their decisions and emotions continuously influence one another. Human society operates as an interconnected web of minds, shaping each other’s beliefs, actions, and responses. Most people remain trapped in this cycle, where external influences trigger internal disturbances, leading to suffering and further imbalance. -/- However, a person who has reached Nirvana no longer contributes to this cycle of mental disturbances. Instead, they exist as a neutral force within the feedback loop, unaffected by external pressures and incapable of generating suffering for themselves or others. Their dynamic state of equilibrium allows them to respond to the world without being influenced by negative forces, ensuring that they do not create further disturbances in the system of human consciousness. -/- How to Achieve and Regulate the State of Nirvana -/- Since Nirvana is a dynamic state, it is not achieved in a single moment but rather through a continuous process of self-regulation. Based on the universal law of balance in nature and the law of karma, an individual must take specific steps to eliminate mental defects and maintain an optimized state of consciousness. -/- 1. Understanding the Nature of Imbalance – The first step is recognizing how ignorance, false beliefs, and uncontrolled desires create internal imbalances. This requires deep introspection and an awareness that suffering is the result of flawed decision-making processes. -/- 2. Eliminating False Systems of Thought – Mental defects arise from incorrect assumptions about reality. An individual must adopt rational thinking based on natural laws, ensuring that their thoughts align with objective truth rather than societal conditioning, superstitions, or emotional biases. -/- 3. Regulating Desires and Attachments – Desires create imbalance when they control the individual, leading to continuous dissatisfaction. To maintain Nirvana, one must learn to regulate desires, keeping them within a balanced framework where they do not dominate decision-making. -/- 4. Practicing Continuous Feedback Adjustment – Since all minds exist within a collective feedback system, an individual must remain conscious of how external influences affect their state of balance. This means developing a high level of self-awareness to prevent unnecessary emotional reactions to external events. -/- 5. Achieving Self-Correcting Homeostasis – Just as a healthy body automatically corrects imbalances (such as regulating temperature and pH levels), the mind in Nirvana must develop a self-correcting mechanism. This means consistently checking whether one’s thoughts, emotions, and actions remain in harmony with the natural law of balance. -/- 6. Avoiding Sources of Mental Disturbance – External influences such as misinformation, emotional manipulation, and toxic environments can disrupt mental balance. A person striving for Nirvana must carefully filter external inputs to ensure that their internal equilibrium remains undisturbed. -/- 7. Integrating Nirvana into Daily Life – Achieving Nirvana is not about retreating from reality but about engaging with it in a state of complete balance. This means making decisions based on reason, clarity, and natural law, ensuring that every action contributes to a stable and harmonious existence. -/- The Balance Between Social Interaction and Privacy -/- While privacy plays an important role in maintaining Nirvana, it is also essential to strike a balance between privacy and social interaction. A person striving for Nirvana must recognize that while solitude and self-reflection are necessary for maintaining mental equilibrium, human beings are inherently social creatures. Healthy social interaction can be a source of joy, support, and growth, and should not be completely avoided in the pursuit of Nirvana. -/- The key to maintaining Nirvana in social settings lies in setting boundaries and choosing relationships that foster peace and balance. Too much social interaction, especially in environments filled with conflict, negativity, or manipulation, can lead to disturbances in mental stability. On the other hand, complete isolation can lead to a lack of social harmony and neglect of collective well-being. -/- Therefore, an individual in Nirvana must be able to navigate between these two aspects of life—engaging in meaningful social interactions while protecting their personal space when needed. This balance is vital in maintaining the mental clarity and emotional stability required to preserve Nirvana in an ever-changing world. By carefully choosing social environments and establishing healthy boundaries, an individual can prevent external disturbances from disturbing their equilibrium. -/- The Importance of Privacy in Maintaining the State of Nirvana -/- In the pursuit of Nirvana, privacy plays a crucial role in preserving mental balance and maintaining the integrity of the individual’s self-regulation process. In a world filled with external pressures, distractions, and unsolicited influences, privacy serves as a protective barrier that allows an individual to maintain personal space and autonomy. -/- Without privacy, the individual is subject to constant interference from external sources—be it through social media, public scrutiny, or external judgments. These external influences can create mental disturbances that disrupt the equilibrium necessary for Nirvana. Privacy allows individuals to maintain their mental clarity, free from the noise of others’ expectations, and to reflect deeply on their own thoughts and feelings without being swayed by outside opinions. -/- By protecting their privacy, an individual can control the flow of information they are exposed to, ensuring that their mental state is not disturbed by harmful or irrelevant stimuli. Privacy enables one to determine their own internal environment, cultivating a space where personal growth and introspection can occur without interference. -/- Furthermore, privacy is integral to emotional regulation. It allows individuals to process their emotions and experiences in a safe environment, enabling them to reach the state of Nirvana without the pressure of external forces. This protection helps avoid unnecessary emotional reactions and preserve mental peace, ensuring that one remains in a state of dynamic balance amidst the complexities of daily life. -/- Nirvana as the Ultimate State of Homeostasis -/- In conclusion, Nirvana, when analyzed through my universal formula, can be understood as the highest state of homeostasis in human consciousness. It is the point at which a person has fully optimized their decision-making process, eliminated all mental defects, and achieved perfect balance with their internal and external reality. However, rather than being a permanent, unchanging state, Nirvana is a dynamic equilibrium, requiring continuous self-regulation to maintain balance. -/- The role of privacy in achieving and maintaining Nirvana cannot be overstated. In a world filled with external distractions and emotional disturbances, privacy is a key factor in preserving mental equilibrium and allowing the individual to maintain the dynamic self-regulation needed to stay in Nirvana. -/- By understanding the steps to achieve and regulate Nirvana, individuals can cultivate mental stability, rational decision-making, and emotional resilience. This explanation provides a scientific and systematic approach to Nirvana, making it not only a spiritual ideal but a practical model for individual and societal well-being. The path to Nirvana is not just a personal journey but a necessary step toward achieving universal equilibrium in human civilization. -/- . (shrink)

In the late 19th century Husserl studied our internal sense of time passing, maintaining that its deep connections into experience represent prima facie evidence for it as the basis for all investigations in the sciences: Phenomenology was born. Merleau-Ponty focused on perception pointing out that any theory of experience must in accord with established aspects of biology i.e. embodied. Recent analyses suggest that theories of experience require non-reductive, integrative information, together with a specific property connecting them to experience. Here we (...) elucidate a new class of information states with just such properties found at the loci of control of complex biological systems, including nervous systems. Complexity biology concerns states satisfying self-organized criticality. Such states are located at critical instabilities, commonly observed in biological systems, and thought to maximize information diversity and processing, and hence to optimize regulation. Major results for biology follow: why organisms have unusually low entropies; and why they are not merely mechanical. Criticality states form singular self-observing systems, which reduce wave packets by processes of perfect self-observation associated with feedback gain g=1. Analysis of their information properties leads to identification of a new kind of information state with high levels of internal coherence, and feedback loops integrated into their structure. The major idea presented here is that the integrated feedback loops are responsible for our ‘sense of self’, and also the feeling of continuity in our sense of time passing. Long-range internal correlations guarantee a unique kind of non-reductive, integrative information structure enabling such states to naturally support phenomenal experience. Being founded in complexity biology, they are ‘embodied’; they also fulfill the statement that ‘The self is a process’, a singular process. High internal correlations and RenéThom-style catastrophes support non-digital forms of information, gestalt cognition, and information transfer via quantum teleportation. Criticality in complexity biology can ‘embody’ cognitive states supporting gestalts, and phenomenology’s senses of ‘self,’ time passing, existence and being. (shrink)

The study investigated the effect of cognitive restructuring on junior secondary school mathematics test anxiety in Oshimili south L.G.A of Delta State. Two research questions and two hypotheses tested at 0.05 level of significance guided the study. Quasi-experimental research design was adopted for this study. The population for this study was a total of 1224 students. These comprised of all the JSS 2 students from Oshimili South Local Government Area of Delta State. Research sample consisted of 120 JSS (...) 2 students with high level of mathematics test anxiety selected through purposive sampling technique. The instrument adopted for this study was Maths anxiety rating scale-R. Data collected from the study were analyzed using mean and ANCOVA. Results obtained from the study indicated that Cognitive restructuring therapy (CRT) was effective on mathematics test anxiety of junior secondary school students. The results equally showed that Cognitive restructuring therapy was more effective on the female students’ mathematics anxiety than their male counterparts. Furthermore, the results indicated a significant difference in the post-test mathematics test anxiety mean scores of students treated with CRT and those in the control group. Also, there was significant difference in the post-test mathematics test anxiety mean scores of male and female students treated with CRT. Based on the findings of this study, some recommendations were noted. The researcher recommended, among others that Schools’ Guidance Counselors should be empowered to make good use of the cognitive restructuring technique, in counseling students who find it difficult to comprehend mathematics skills. (shrink)

An AC servomotor which is mostly a two-phase induction motor with two stator field coils placed 90 electrical degrees apart used for controlling position, speed and acceleration in manufacturing industries. In this paper, a two-phase induction motor has been designed with a fuzzy logic and observer based controllers to improve the performance of the system. Comparison of the AC servomotor with the proposed controllers for tracking a step and a square desired position signal input has been (...) done using Matlab/Simulink toolbox and a promising result obtained. (shrink)

Although expert consensus states that critical thinking (CT) is essential to enquiry, it doesn’t necessarily follow that by practicing enquiry children are developing CT skills. Philosophy with children programmes around the world aim to develop CT dispositions and skills through a community of enquiry, and this study compared the impact of the explicit teaching of CT skills during an enquiry, to The Philosophy Foundation's philosophical enquiry (PhiE) method alone (which had no explicit teaching of CT skills). Philosophy with children is (...) also said to improve metacognitive (MC) skills but there is little research into this claim. Following observable problems with ensuring genuine metacognition was happening in PhiE sessions - on a reasonably strong understanding of what metacognition is – a method has been developed and trialed in this study to bring together, in mutual support, the development of critical thinking and metacognitive skills. Based on the work of Peter Worley and Ellen Fridland (KCL)The Philosophy Foundation ran an experimental study with King's College London in Autumn 2017 and Autumn 2018 to compare the impact of teaching CT skills and MC skills against classes that just have philosophical enquiry. The approach developed and used for the study employs the explicit teaching of some CT and MC skills within the context of a philosophical enquiry (as opposed to stand-alone teaching of these skills) and yields some positive findings both qualitative and quantitative. Both studies took place over one term (12 weeks) and a control and intervention group were used in each study. This report focuses on the second year of the study, with 220 ten and eleven-year-old children involved in eight classes across three state schools in South East London. Although there were limitations to the study the results indicate that the explicit teaching of these skills during a philosophical enquiry can help children use CT and MC skills more successfully than philosophical enquiry alone. (shrink)

In 2012, a major traffic safety organization tasked the MIT AgeLab with developing a data-driven system for rating the effectiveness of new technologies intended to improve safety. Such a system was envisioned as having the potential to educate and guide consumers towards more confident and strategic purchasing decisions, ideally encouraging adoption of technologies with demonstrated safety benefit. In addition, an evaluation of the status and extent of existing data was seen as a way of identifying research gaps in the (...) class='Hi'>state of knowledge about safety systems. The focus was on technologies as a class, not on a rating review of individual vehicle model implementations. As conceptualized, the system aimed to complement traditional NCAP style ratings as well as to provide consumers with transparent information on early stage and often improving safety technologies. Development of the rating system and identification of data was undertaken in consultation with a range of academic, industrial, consumer, NGO, and governmental experts as well as with representatives of many of the major automotive manufacturers and suppliers. -/- A key observation that emerged was that data on objectively demonstrable real-world benefits were generally sparse and often lower than expectations based on theoretical considerations, simulation studies, or pre-production evaluations. A number of experts and industry representatives expressed some surprise at both the divergence between theoretical and observed benefits and the relative scarcity of data upon which to make objective assessments, while others were quite aware of these issues and the need for the development of objective data under real-world operating conditions. A number of factors that might be relevant to understanding why such differences between expected and observed benefits exist were identified. One outcome of this effort was the founding of the Advanced Vehicle Technology (AVT) consortium to collect and examine objective data under naturalistic driving conditions of how drivers interact with, engage or don’t engage, various production safety and driver assistance systems. This ongoing effort is contributing to insights concerning actual benefits and reasons for benefit gaps. -/- Drawing from our initial work, as well as newer sources of data, we argue that the evaluation and rating of safety and driver assistance technologies for informing the consumer and the public at large should consider both theoretical potential and existing demonstrated benefit of specific technologies. This position is increasingly relevant as the effectiveness of many newer technologies have the potential to actually improve over the lifecycle of a vehicle through software updates. The emphasis on ratings based on observed benefit for actual drivers under real-world conditions is proposed to be complementary, rather than competing with, ratings focused largely on controlled test track evaluations of engineered capability. In addition, a case is made for providing ratings that assesses benefit relative to overall crash, injury, and fatality rates – and in relation to the specific scenario / crash event type that a given technology is intended to address. This approach should aid consumers in considering the extent to which a specific technology is or is not relevant to their particular driving needs. (shrink)

In this paper, a 3 DOF gyrscope position control have been designed and controlled using optimal control theory. An input torque has been given to the first axis and the angular position of the second axis have been analyzed while the third axis are kept free from rotation. The system mathematical model is controllable and observable. Linear Quadratic Integral (LQI) and Linear Quadratic State Feedback Regulator (LQRY) controllers have been used to improve the performance of the system. (...) Comparison of the system with the proposed controllers for tracking a desired step and random angular position have been done using Matlab/Simulink Toolbox and a promising results has been analyzed. (shrink)

Comprehensive Plan for Population Growth Control & Senior Citizen Social Safety Net in the Philippines -/- To ensure sustainable population growth while also supporting senior citizens who have no children or lack financial support, the government must integrate social safety net laws for both family planning and elderly welfare. -/- I. Population Growth Control Through Social Safety Net Laws -/- 1. TAX REFORMS TO INCENTIVIZE SMALLER FAMILIES -/- A. Incentives for Small Families -/- Higher tax deductions for families with one (...) or two children. -/- Gradual removal of tax benefits for families with more than two children. -/- Corporate tax incentives for businesses that provide family planning services. -/- B. Tax Penalties for Large Families -/- Higher progressive taxation on families with three or more children. -/- Luxury taxes on housing, vehicles, and government subsidies for large families. -/- 2. EDUCATION REFORMS FOR RESPONSIBLE FAMILY PLANNING -/- A. Strengthening Sex Education (Comprehensive Sexuality Education – CSE) -/- Mandatory inclusion in the school curriculum from Grade 5 onward. -/- Covers reproductive health, contraception, financial responsibility, and gender equality. -/- B. Scholarships & Financial Aid for Small Families -/- Additional educational subsidies for children from families with one or two kids. -/- Gradual reduction of education subsidies for larger families. -/- 3. EMPLOYMENT & SOCIAL WELFARE REFORMS -/- A. Job Incentives for Women & Working Parents -/- Work-from-home incentives and subsidized childcare for working mothers. -/- Paid maternity leave benefits tied to small family sizes. -/- B. Adjustments to 4Ps Social Welfare Program -/- Full cash benefits limited to the first two children. -/- Mandatory family planning education to continue receiving benefits. -/- 4. AI & BIG DATA FOR POPULATION PLANNING -/- AI-driven demographic tracking to adjust tax policies, social benefits, and economic incentives. -/- Predictive modeling for workforce planning to prevent future labor shortages. -/- 5. URBAN & RURAL DEVELOPMENT STRATEGIES -/- Housing and urban planning incentives for small families. -/- Smart city initiatives to balance population density. -/- II. Social Safety Net for Senior Citizens Without Children or Financial Support -/- 1. Universal Pension & Financial Support Programs -/- A. Strengthening the SSS and GSIS Pension System -/- Mandatory government contributions for all workers, regardless of employment sector. -/- Higher pension benefits for seniors without children or financial support. -/- B. New “Guaranteed Minimum Pension” Program -/- Senior citizens without private savings receive a baseline pension from the government. -/- Indexed to inflation to ensure financial security in old age. -/- 2. Housing & Living Assistance for Seniors Without Family Support -/- A. Senior Citizen Cooperative Housing Program -/- Government-subsidized shared housing facilities for elderly individuals without family support. -/- Community-based senior housing with healthcare and caregiving services. -/- B. Expansion of Public Nursing Homes -/- New state-run assisted living facilities in every province. -/- Affordable senior apartments with subsidized utilities and food programs. -/- 3. Healthcare & Insurance for Elderly Without Family Support -/- A. Expansion of PhilHealth & Free Healthcare Services -/- Automatic PhilHealth coverage for all seniors with no child support. -/- Higher government healthcare subsidies for single and childless seniors. -/- B. Free Home-Based Healthcare -/- Barangay-level healthcare workers assigned to provide free home visits for elderly citizens. -/- Mobile clinics and telemedicine for those in remote areas. -/- 4. Employment & Social Engagement for the Elderly -/- A. Senior Employment & Livelihood Programs -/- Tax incentives for companies hiring seniors (part-time or consultancy roles). -/- Government-backed microfinance loans for seniors starting small businesses. -/- B. “Adopt-a-Senior” Community Program -/- Encourage local communities to support senior citizens without family assistance. -/- Volunteer-based programs where younger individuals help care for seniors. -/- III. Implementation Challenges & Solutions -/- A. Overcoming Religious & Cultural Barriers -/- Frame policies as “family economic security programs” rather than population control. -/- Community-based awareness campaigns to promote responsible parenthood. -/- B. Ensuring Fair Implementation in Rural Areas -/- Deploy mobile healthcare teams to reach isolated seniors and educate rural families. -/- Offer financial rewards for barangays with successful family planning programs. -/- C. Balancing Population Growth & Workforce Needs -/- Encourage skilled migration to prevent future labor shortages. -/- Promote education and automation to compensate for a smaller workforce. -/- Final Recommendations -/- Integrate population planning into the national economic strategy. -/- Create a “National Senior Citizen Welfare Act” ensuring financial security for the elderly. -/- Strengthen AI-driven demographic management to balance population growth. -/- . (shrink)

Steam turbine generator is an electromechanical system which converts heat energy to electrical energy. In this paper, the modeling, design and analysis of a simple steam turbine generator have done using Matlab/Simulink Toolbox. The open loop system have been analyzed to have an efficiency of 76.92 %. Observer based & linear quadratic regulator (LQR) controllers have been designed to improve the generating voltage. Comparison of this two proposed controllers have been done for increasing the performance improvement (...) to generate a 220 Dc volt. The simulation result shows that the steam turbine generator with observer based controller has a small percentage overshoot with minimum settling time than the steam turbine generator with LQR controller and the open loop system. Finally, the steam turbine generator with observer based controller shows better improvement in performance than the steam turbine generator with LQR controller. (shrink)

After ratifying the Framework Convention for Tobacco Control in 2004, Bangladesh enacted anti-tobacco laws, policies, and administrative measures. Evidence suggests that the progress so far has not been significant, and Bangladesh will most likely fail to meet its target to become tobacco-free by 2040. This study undertakes a national-level political economy analysis to explore the dynamics that affect the processes of required tobacco policy reforms and implementation. Based on a desk review of pertinent pieces of literature and key informant (...) interviews, this research examines the political behavior of key individuals, institutional reform initiatives, and the government’s commitment to the tobacco control agenda. The findings indicate that the political will of becoming tobacco-free is explicitly present in key narratives. However, intra-government conflict of interests and incentives, the skewed commitment of government bodies, state-business nexus, incapacity of vital organizations, and the dubious role of key individuals and committees fail to translate this will into active implementation. The article concludes that the idea of tobacco control remains a strategic accommodation, and its implementation requires genuine commitment and wider public support. The government must confer adequate authority and resources to the national tobacco control cell and call for agencies to convene to the common of creating a tobacco-free Bangladesh. (shrink)

The transferability problem—whether the results of an experiment will transfer to a treatment population—affects not only Randomized Controlled Trials but any type of study. The problem for any given type of study can also, potentially, be addressed to some degree through many different types of study. The transferability problem for a given RCT can be investigated further through another RCT, but the variables to use in the further experiment must be discovered. This suggests we could do better on the epistemological (...) problem of transferability by promoting, in the repeated process of formulating public health guidelines, feedback loops of information from the implementation setting back to researchers who are defining new studies. (shrink)

Solving the Turbulence Problem in Physics Using the Universal Formula -/- By Angelito Malicse -/- Introduction -/- Turbulence remains one of the greatest unsolved problems in physics. It is a chaotic, unpredictable phenomenon observed in fluid dynamics, affecting airflow over aircraft wings, ocean currents, wind energy systems, and even blood flow in the human body. Despite the well-established Navier-Stokes equations governing fluid motion, turbulence remains difficult to fully predict and control due to its inherent complexity. -/- In this essay, I (...) will demonstrate how my universal formula, based on three fundamental laws of nature, provides an exact solution to the turbulence problem. By applying these laws, we can achieve a deeper understanding of turbulence, allowing for more effective prediction, mitigation, and control in various real-world applications. -/- Understanding Turbulence in Light of the Universal Formula -/- Turbulence is a manifestation of complex interactions within a system. According to my universal formula, all systems must follow natural laws governing balance, causality, and feedback mechanisms. Let us analyze turbulence through the lens of these principles. -/- 1. The Law of Karma: Cause, Effect, and Systemic Integrity -/- The first law in my universal formula is the Law of Karma, which extends beyond the traditional idea of cause and effect to encompass the principle of systemic integrity. A system must be free from defects or errors to function properly. If turbulence occurs, it indicates an imbalance or defect within the system. -/- In fluid dynamics, turbulence arises when the cause (flow conditions) leads to an unstable effect (chaotic motion). This imbalance can be seen in: -/- Aircraft aerodynamics, where airflow disruptions create drag and instability. -/- Wind turbines, where turbulent wind patterns reduce energy efficiency. -/- Maritime navigation, where water turbulence increases resistance and fuel consumption. -/- Applying the Law of Karma, turbulence can be controlled by designing systems that minimize defects, ensuring smooth energy transfer within the flow. AI-driven optimization can detect turbulence before it fully develops, correcting imbalances through real-time adjustments. -/- 2. The Law of Balance in Nature -/- The second law states that all natural systems seek balance. Turbulence arises when the energy distribution in a fluid system becomes uneven, disrupting the balance. This is seen in: -/- Boundary layers on aircraft wings, where pressure imbalances lead to turbulence. -/- Ocean currents, where temperature and salinity differences create unstable vortices. -/- To control turbulence, we must restore balance in the system. This can be achieved through: -/- Dynamic flow control, using AI to adjust surfaces (such as aircraft flaps or turbine blades) in real time. -/- Energy redistribution, ensuring fluid motion remains stable by adjusting velocity gradients or temperature differences. -/- Feedback-based corrections, applying intelligent algorithms that predict and counteract turbulence. -/- By harmonizing energy distribution, we can prevent turbulence from escalating, bringing the system back into natural equilibrium. -/- 3. The Law of Feedback Regulation -/- The third law states that all systems operate through feedback mechanisms. Turbulence, despite appearing chaotic, follows a pattern that can be measured, analyzed, and corrected through continuous feedback. -/- Birds adjust their wing angles dynamically to minimize turbulence, an example of natural feedback control. -/- Fish use their fins to counteract water turbulence, stabilizing their movement. -/- AI systems can mimic these natural mechanisms to adjust airflow, ship navigation, or wind turbine performance. -/- Applying the Law of Feedback Regulation, we can create AI-driven turbulence control systems that: -/- Predict turbulence using real-time sensor data. -/- Adjust system parameters dynamically to reduce turbulence intensity. -/- Continuously learn and improve based on new turbulence patterns. -/- This approach follows nature’s own strategy for stability, aligning technology with fundamental natural principles. -/- Applying the Universal Formula to Solve Turbulence -/- By integrating the three universal laws, we can develop a Unified AI-Driven Turbulence Control System applicable to multiple fields: -/- ✅ Aviation: AI-based wing and engine adjustments to minimize drag. ✅ Maritime Transport: Smart hull designs to reduce water resistance. ✅ Wind Energy: Adaptive wind turbine blades for optimal efficiency. ✅ Medical Applications: AI-assisted blood flow regulation to prevent clot formation. -/- This system ensures real-time adaptation, aligning human technology with nature’s fundamental laws. -/- Conclusion -/- The turbulence problem in physics, long considered unsolvable, is fundamentally a problem of imbalance, defective systems, and insufficient feedback control. By applying my universal formula, which follows the natural laws of karma (causality), balance, and feedback, we can fully understand, predict, and control turbulence in all systems. -/- Through AI-driven optimization, dynamic corrections, and harmonizing energy flow, we can finally resolve turbulence across aviation, maritime, wind energy, and even biological systems. My universal formula provides the exact and only solution to this problem, proving that all complex phenomena in nature can be understood through fundamental natural laws. -/- By implementing these principles, we take a step toward a future where turbulence is no longer an obstacle, but a controlled phenomenon guided by nature’s own balance. -/- . (shrink)

Respect for autonomy is a central moral principle in bioethics. The concept of autonomy can be construed in various ways. Under the non-ideal conceptualization proposed by Beauchamp and Childress, everyday choices of generally competent persons are autonomous to the extent that they are intentional and are made with understanding and without controlling influences. It is sometimes suggested that authenticity is important to personal autonomy, so that inauthenticity prevents otherwise autonomous persons from making autonomous decisions. Building from Beauchamp and Childress’s theory, (...) this article develops a non-ideal authenticity-based conceptualization of personal autonomy. Factors that indicate inauthentic decision-making are explicated, and the full concept is defended from three expected objections. The theory is then tested on a paradigm case which has concerned theorists and practitioners for some time, namely the possible inauthenticity of anorexia nervosa patients’ decision-making. It is concluded that the theory seems to be fruitful in analyses of the degree of autonomy of patients’ decision-making, and that it succeeds in providing reliable action-guidance in practical contexts. (shrink)

The mind of man is central to the structure and functioning of the physical world. Modern physical theory indicates that the mind stands in a relationship of equals to the physical world. Both are fundamental, neither can be reduced to the other, and both require each other for their full understanding. This thesis is at odds with the view of the universe found in Newtonian mechanics as well as the generally held view among contemporary physicists of modern physical theory. (...) Since the Renaissance, man has come to understand a great deal about the physical world, and he has gained significant control over it. This increased power over the physical world has occurred hand in hand with the assumption that the structure and functioning of the physical world is essentially independent from his cognitive functioning. According to this assumption, if man’s cognitive capacity did not exist, the functioning of the physical world would not be fundamentally altered. This last statement is not in fact correct, and modern physical theory, and even fundamentals underlying Newtonian mechanics, provide evidence to attest to this. Nonetheless, contemporary physicists for the most part do not see that the relationship of human cognition to the physical world is radically altered in their own modern theory, theory that is supported by a great deal of empirical data. Instead, attempting to preserve the thesis that the structure and functioning of the physical world is independent of the mind while on a practical level relying on modern theory that contradicts this thesis, physicists have placed themselves in the position of wondering at times exactly what is the nature of the physical world at the same time they obtain experimental results concerning the physical world that can only be labeled astonishing in their precision and the scope of their implications. Modern physical theory consists of three main components: 1) the special and general theories of relativity; 2) quantum mechanics; and 3) statistical mechanics. There are very successful theories that have been developed on the basis of these three bedrock areas. An example of one is quantum electrodynamics. But these theories owe their conceptual foundation to the three components mentioned. The basic issues at the core of these three components also are expressed in these later theories. In addition, there are new unresolved issues of a fundamental nature concerning the conceptual integrity of these later theories that do not apply to quantum mechanics, relativity theory, and statistical mechanics. Quantum mechanics and relativity theory are areas I have written about for over twelve years. The nature of statistical mechanics has also been of interest to me during this time. But when I took a serious look in 1993 at Tolman’s (1938) The Principles of Statistical Mechanics, it became clear that the mind is linked to the physical world in statistical mechanics, a relationship I had found earlier in both relativity theory and quantum mechanics. It was after reading Tolman’s justification of the method of statistical mechanics in the original that I decided to write this book. When I found that the three components of modern physical theory all pointed to the same relationship between mind and the physical world, it became clear that the fundamental isolation of the mind from the physical world that has characterized our experience since the development of Newtonian mechanics is unfounded. Based on empirically supported principles of modern physical theory, I determined that the appropriate assumption for one’s experience, that the mind is linked to the physical world, could be stated with confidence. The impact of this change in assumption concerning the relationship of man to the cosmos in modern physical theory will find its way into our everyday experience. It will perhaps have no greater effect than in reducing the sense of isolation of man from the world that has characterized modern existence. (shrink)

Regarding the relation of Plato’s early and middle period dialogues, scholars have been divided to two opposing groups: unitarists and developmentalists. While developmentalists try to prove that there are some noticeable and even fundamental differences between Plato’s early and middle period dialogues, the unitarists assert that there is no essential difference in there. The main goal of this article is to suggest that some of Plato’s ontological as well as epistemological principles change, both radically and fundamentally, between the early and (...) middle period dialogues. Though this is a kind of strengthening the developmentalistic approach corresponding the relation of the early and middle period dialogues, based on the fact that what is to be proved here is a essential development in Plato’ ontology and his epistemology, by expanding the grounds of development to the ontological and epistemological principles, it hints to a more profound development. The fact that the bipolar and split knowledge and being of the early period dialogues give way to the tripartite and bound knowledge and benig of the middle period dialogues indicates the development of the notions of being and knowledge in Plato’s philosophy before the dialogues of the middle period. -/- Keywords Plato; early dialogues; middle dialogues; being; knowledge; development -/- Introduction The differences between two groups of the early and middle period dialogues have always been a matter of dispute. Whereas the developmentalists like Vlastos, Silverman (2002), Teloh (1981), Dancy (2004) and Rickless (2007) think that from the early to the middle dialogues Plato’s philosophy changes, at least in some essential points, the unitarists like Kahn, Cherniss and Shorey believe that there happens no development and the differences must be taken as natural, ignorable and even pedagogic. In his well-known article, Socrates contra Socrates in PLATO, Vlastos lists ten theses of difference between two groups of dialogues. The first group which includes Plato’s early dialogues he divides to 'elenctic' (Apology, Charmides, Crito, Euthyphro, Gorgias, Hippias Minor, Ion, Laches, Protagoras and Republic I) and 'transitional' (Euthydemus, Hippias Major, Lysis, Menexenus and Meno) dialogues. These transitional come after all the elenctic dialogues and before all the dialogues of the second group which compose Plato’s middle period dialogues, including (with Vlastos' chronological order) Cratylus, Phaedo, Symposium, Republic II-X, Phaedrus, Parmenides and Theaetetus (1991, 46-49). Vlastos asserts strictly that his list of differences are 'so diverse in content and method that they contrast as sharply with one another as with any third philosophy you care to mention, beginning with Aristotole’s' (ibid, 46). Vlastos’ list of differences between two Socrateses is considered a view breaking sharply between the early and the middle dialogues. Besides all ten differences between the two Socrateses in Vlastos’ list that can be supportive for our doctrine here, we intend to focus on some ontological as well as epistemological distinctions that have not completely been discussed hitherto. Contrary to the developmentalist theory of Vlastos, unitarian theory of Charles Kahn wishes to eliminate any substantial difference between the early and the middle dialogues. He distinguishes seven 'pre-middle' or 'threshold' dialogues including Laches, Charmides, Euthyphro, Protagoras, Meno, Lysis and Euthydemus from the other Socratic dialogues which he calls 'earliest group' (1996, 41). The threshold dialogues, Kahn thinks, 'embarke upon a sustained project' that is to reach to its climax in the middle period dialogues, namely Phaedo, Symposium and Republic. Believing in that there is no 'fundamental shift'between the early and middle dialogues (ibid, 40), Kahn thinks the Socratic dialogues are just the 'first stage' with a 'deliberate silence' towards the theories of later periods (ibid, 339). One of the reasons of the surprising fact that Plato gives no hint of the metaphysics and epistemology of the Forms in the early dialogues, he thinks, is the pedagogical advantages of aporia. He thinks that Plato 'obscurely', and mostly because of education, hinted to some doctrines and conceptions in his early dialogues and with the aim of clarifying them only in the later ones (ibid, 66). The seven threshold dialogues, Kahn asserts, 'had been designed from the first' to prepare the pupils and readers for the views expounded in the middle period dialogues (ibid, 59-60). To show that the differences of the two Socrateses of the early and middle period dialogue are in their onto-epistemological grounds and thence cannot be explained by a unitaristic view, we try to draw the ontological and epistemological principles of the early dialogues in the first part below in order to show, in the second part, that those principles have been developed in the middle period dialogues. -/- A. The Onto-Epistemologic Principles of the Early Dialogues Socratic dialogues are paradoxical about knowledge because while being knowledge-oriented always searching for knowledge, they deny it and even never discuss it directly. Three elements of Socrates’ way of searching Knowledge throughout the early dialogues, i.e. Socratic 'what is X?' question, his disavowal of knowledge and his elenctic method combined together produce something like a circle which works, more or less, in the same way in these dialogues. Though this circle is an embaressing inquiry always resulting in ignorance instead of knowledge, its motivation is surprisingly Socrates’ passionate enthusiasm for knowledge, an intensive love of wisdom. The starting point of this circle is Socrates’ confession of having no knowledge which might be explicitly asserted or presupposed, maybe because it was one of the famous characteristics of Socrates; a confession always paradoxically accompanied with his intense longing for knowledge (e.g., Gorgias 505e4-5). Every time Socrates encounters with someone who thinks he knows something (οἴεταί τι εἰδέναι) (Apology 21d5) and tries to examine him. This examination seems to be the simplest one asking just what it is that he knows. Socrates’ elenchus, therefore, is always connected with 'what is X?' (τίς ποτέ ἐστιν) question, a question that most of the early dialogues of Plato are concerned with; 'what is courage?' in the Laches, 'what is piety?' in Euthydemus, 'what is temperance?' in Charmides and 'what is beauty?' in Hippias Major. This question we call here 'Socratic question' and probably is the very question the historical Socrates used to employ, is tightly interrelated with both his disavowal and his elenchus. He disclaims knowledge because he cannot find the answer to the question himself and he rejects others’ since they cannot offer the correct answer too. Every interlocutor can claim he knows X, if and only if he can answer the Socratic question. Otherwise, he is more of an ignorant than of a knower of τί ποτέ ἐστι X. Knowing the answer to this question is, thus, knowledge’s criterion for Socrates. Having found out that he cannot answer what it is which he would claim to know, the interlocutor comes to the point Socrates was there at the beginning. The least advantage of this circle is that he becomes as wise as Socrates does about the subject, becoming aware that he does not know it. At the end of the circle they are both still at the beginning, not knowing what X is. So let us first take a glance at these three elements. Socratic disavowal of knowledge is strictly asserted in some passages. At Apology 21b4-5, Socrates says: -/- I do not know of myself being wise at all (οὔτε μέγα οὔτε σμικρὸν σύνοιδα ἐμαυτῷ σοφὸς ὤν) -/- Moreover, at 21d4-6: -/- None of us knows anything worthwhile (καλὸν κἀγαθὸν εἰδέναι) …. I do not know (οἶδα) neither do I think I know. -/- In Charmides Socrates speaks about a fear about his probable mistake of thinking that he knows (εἰδέναι) something when he does not (166d1-2). The somehow generalization of this disavowal can be seen in Gorgias. After calling his disavowal 'an account that is always the same' (509a4-5), Socrates continues (a5-7): -/- I say that I do not know (οἶδα) how these things are, but no one I have ever met, like now, who can say anything else without being absurd. -/- At the end of Hippias Major (304d7-8), Socrates affirms his disavowal of knowledge of 'what is X?' this time about the fine: -/- I do not know (οἶδα) what that is itself (αὐτὸ τοῦτο ὅτι ποτέ ἐστιν). Some other passages, however, made a number of scholars dubious about Socrates’ disavowal. Vlastos mentions Apology 29b6-7 as an evidence : 'that to do wrong and to disobey one’s master, both god and men, I know (οἶδα) to be evil and shameful'. He thinks that if we give this single text 'its full weight' it can suffice to show that Socrates does claim knowledge of a moral truth (1985, 7). Vlastos’ claim is not admittable since it would be too strange, I think, for a man like Socrates to violate his disavowal claim just after emphasizing it. We can see his claim just before the already mentioned passage: -/- And surely it is the most blameworthy ignorance to believe that one knows what one does not know. It is perhaps on this point and in this respect, gentlemen, that I differ from the majority of men and if I were to claim that I am wiser than anyone in anything it world be in this, that, as I have no adequate knowledge (οὐκ εἰδὼς ἱκανῶς) of things in the underworld, so I do not think I have (οὐκ εἰδέναι) (Apology 29b1-6) Vlastos tries to solve what he calls the 'paradox' of Socrates’ disavowal of knowledge distinguishing the 'certain' knowledge from 'elenctic' knowledge (1985, 11) and thinking that when Socrates avows knowledge, we must perceive it as an elenctic knowledge, a knowledge its content 'must be propositions he thinks elenctically justifiable' (ibid, 18). Irwin’s solution is the distinction of knowledge and belief. He approves that Socrates does not 'explicitly' make such a distinction, but still thinks that Socrates’ 'test for knowledge would make it reasonable for him to recognize true belief without knowledge, and his own claims are easily understood if they are claims to true belief alone' (1977, 40). While I agree with Vlastos up to a point, I strongly disagree with Irwin about the early dialogues. As I will try to show below, we are not permitted to consider any kind of distinction within knowledge in Socratic dialogues because only one category of knowledge is alluded to there and the distinction of knowledge and belief thoroughly belongs to the second Sorcates. Although no kind of distinction can be admittable here, I think Vlastos’ distinction can be accepted only if we regard it as a distinction between knowledge, which is unique and without any, even incomparable, rival, and a semi-idiomatic and ordinary one that is a necessary requirement for any argument, and thus, unavoidable even for someone who does not claim any kind of knowledge. An apparent evidence of this is Gorgias 505e6-506a4: -/- I go through the discussion as I think it is (ὡς ἄν μοι δοκῇ ἔχειν), if any of you do not agree with admissions I am making to myself, you must object and refute me. For I do not say what I say as I know (οὐδὲ γάρ τοι ἔγωγε εἰδὼς λέγω ἃ λέγω) but as searching jointly with you (ζητῶ κοινῇ μεθ᾽ ὑμῶν). -/- The minimal degree of knowledge everyone must have to take part in an argument, conduct it and use the phrase "I know" when it is necessary is what Socrates cannot deny. We can call it elenctic knowledge only if we agree that it is not the kind of knowledge that Socrates has always been searching, the one that can be accepted as the answer of Socratic 'what is X?' question. His disavowal of knowledge is applied only to the knowledge which can truly be the answer of Socratic question and pass the elenctic exam; a knowledge that, I believe, is never claimed by first Socrates. Socrates conducts his method of examining his interlocutors’ knowledge, our second element here, by almost the same method repeated in Socratic dialogues. That whether we are allowed to regard all the examinations of Socrates in the early dialogues as based on the same or not has been a matter of dispute. Vlastos himself (1994, 31) distinguished Euthydemas, Lysis, Menexenns and Hippias Major from the other Socratic dialogues because he thinks Socrates has lost his faith to elenchus in there. Irwin (1977, 38) distinguishes Apology and Crito where Socrates’ own convictions is present. Contrary to some scholars like Benson (2002, 107) who take elenchus in all the Socratic dialogues as a unique method, Michelle Carpenter and Ronald M. Polansky (2002, 89-100) argue pro the variety of methods of elenchus. Thomas C. Brickhouse and Nicholas D. Smith (2002, 145-160) even reject such a thing as Socratic elenchus which can gather all of the Socrates’ various arguments under such a heading. There can be no solution for the problem of elenchus, they think, is due to 'the simple reason that there is no such thing as 'the Socratic elenchos"'(p.147). Though we consider elenchus a somehow determined process and a part of Socratic circle in the early dialogues, all we assume is that whatever differences it might have in different dialogues, it has the same onto-epistemological principles and, thus, we are not going to take it necessarily as a unique method. This method sets out to prove that the interlocutors are as ignorant as Socrates himself is. That whether elenchus is constructive, capable of establishing doctrines as Vlastos (1994) or Brickhouse and Smith (1994, 20-21) believe or not is another issue to which this paper is not to claim anything. What is crucial for our discussion here is that elenchus does not reach to the very knowledge Socrates is looking for. This is strictly against Irwin who thinks that not only elenchus leads to positive results, 'it should even yield knowledge to match Socrates’ conditions'(1977, 68, cf. 48). He does not explain where and how they really yield to that kind of knowledge. He explains his elenctic method in his apology in the court (Apology 21-22), that how he used to examine wise men, politicians, poets and all those who had the highest reputation for their knowledge and every time found that they have no knowledge. If we accept, as I strongly do, that Socrates’ disavowal of his knowledge is not irony, it might seem more reasonable to agree that the process that has that disavowal as its first step cannot be irony as well. The key of the circle which can explain why Socrates disclaims knowledge and how he can reject others’ claim of having any kind of knowledge lies in the third element, Socratic question. In Hippias Major (287c1-2), Socrates asks: 'Is it not by Justice that just people are Just? (ἆρ᾽ οὐ δικαιοσύνῃ δίκαιοί εἰσιν οἱ δίκαιοι). He insists at 294b1 that they were searching for that by which (ᾧ) all beautiful things are beautiful (cf. b4-5, 8). At Euthyphro 6d10-11 it is said that the Socratic question is waiting for 'the form itself (αὐτὸ τὸ εἶδος) by which (ᾧ) all the pious actions are pious; and at 6d11-e1: -/- Through one form (που μιᾷ ἰδέᾳ) impious actions are impious and pious actions pious. -/- Since the X itself is that by which X is X, knowing 'X itself' is the only way of knowing X. It is probably because of this that Socrates makes the distinction between the ousia as a right answer to the question and effect as a wrong one: -/- I am afraid, Euthyphro, that when you were asked what piety is (τὸ ὅσιον ὅτι ποτ᾽ ἐστίν) you did not wish to make clear its nature itself (οὐσίαν … αὐτοῦ) to me, but you said some effect (πάθος) about it. (Euthp. 11a6-9) -/- 1. Knowledge of what X is Now it is time to look for the onto-epistemological principles of Socratic circle and its three elements. It cannot reasonably be expected from the first Socrates to present us explicitly and clearly formulated principles of his onto-epistemology when such explications cannot be found even in the second Socrates who has some obviously positive theoris. Since there must be some principles underlying this first systematic inqury of knowledge, we must seek to them and be satisfied with elicitation of the first Socratas’ principle. What will be drawn out as his principles cannot and must not, thus, be taken as very fix and dogmatic principles. Some very slightest principles and grounds suffice for our purposes here. The first principle that is the prima facie significance of the Socratic question and his implementation of all those elenctic arguments I call the principle of 'Knowledge of What X is' (KWX): -/- KWX To know X, it is required to know what X is. -/- Aristotle (Metaphysics 1078b23-25, 27-29, 987b4-8) takes Plato’s τί ἐστι question as seeking the definition of a thing that is the same as historical Socrates’ search but applying to a different field. That Plato’s 'what is X?' question was a search for definition became the prevailed understanding of this question up to now. I am going neither to discuss the answer of Socratic question nor to challenge taking it as definition. What I am to insist is that knowledge is attached firmly to the answer of the question: Knowledge of X is not anything but the knowledge of what X is. It entails, certainly, the priority of this knowledge to any other kind of knowledge about X but it also has something more fundamental about the relation of knowledge and Socratic question. Socrates’ exclusive focus on the answer of his question can authorize the consideration of such an essential role for KWX in his epistemolgoy. The total rejection of his interlocutors’ knowledge when they are unable to answer the question can be regarded as a strong evidence for it. Socrates’ elenctic method and his rejection of others’ knowledge in the early dialogues, which all end aporetically with no one accepted as knower and nothing as knowledge, prevent us from finding any positive evidence for this. We have to be content, therefore, of negative evidences which, I think, can be found wherever Socrates rejects his interlocutors’ knowledge when they are not able to give an acceptable answer to his 'what is X?' question. 2. Bipolar Epistemology Socrates’ rejection of his interlocutors’ knowledge has another epistemological principle as its basis. Let me call this principle Bipolar Epistemology' (BE): BE There is no third way besides knowledge and Ignorance. -/- BE says that about every object of knowledge there are only two subjective statuses: knowledge and Ignorance. Socrates’ disavowal, however, says nothing but that he is ignorant of knowledge of X because he does not know what X is. This means that BE is presupposed here. Socrates’ elenchus and his rejection of interlocutors’ having any kind of knowledge are the necessary results of the fact that he does not let any third way besides knowledge and ignorance. The first Socrates never let anyone partly know X or have a true opinion about it, as he would not let anyone know anything about X when he did not know what X is. -/- 3. Bipolar Ontology The principle of BE in first Socrates’ epistemology is parallel to another principle in his ontology. Plato’s bipolar distinction between being and not being is as strict and perfect as his distinction between knowledge and ignorance. This principle I shall call the principle of 'Bipolar Ontology' (BO): BO Being is and not being is not. BO is apparently the same with the well-known Parmenidean Principle of being and not being (cf. Diels-Kranz (DK) Fr. 2.2-5). Euthydemus’ statement against the possibility of false knowledge can be good evidence for this principle: -/- The things which are not surely do not exist (τὰ δὲ μὴ ὄντα … ἄλλο τι ἢ οὐκ ἔστιν). (Euthydemus 284b3-4) -/- He continues (b4-5): -/- There is nowhere for not being to be there (οὖν οὐδαμοῦ τά γε μὴ ὄντα ὄντα ἐστίν). -/- That BE does not let true opinion as a third option besides knowledge and ignorance seems to be related to BO’s rejecting a third option besides being and not being, which is itself the basis of the impossibility of false belief. Socrates’ elaborate discussion of the problem of false belief in Theatetus that leads to a more decisive discussion and finally to some solutions in Sophist can make our consideration of BO for the first group of dialogues authentive. -/- 4. &5. Split Knowledge and Split Being The fourth principle I shall call the principle of 'Split Knowledge' (SK): -/- SK Knowledge of X is separated from any other knowledge (of anything else) as if the whole knowledge is split to various parts. -/- This Principle is hinted and criticized as Socrates’ way of treating with knowledge in Hippias Major: -/- But Socrates, you do not contemplate the entireties of things, nor do people you have used to talk with (τὰ μὲν ὅλα τῶν πραγμάτων οὐ σκοπεῖς, οὐδ᾽ ἐκεῖνοι οἷς σὺ εἴωθας διαλέγεσθαι). (301b2-4) -/- Contrary to Rankin who regards the passage as 'antilogical, almost eristic in tone rather than presenting a serious philosophy of being' (1983, 54), I think it can be taken as serious. Hippias criticizes Sorcates that he does not contemplate (σκοπεῖς) the entireties of things (ὅλα τῶν πραγμάτων), a critique which Socrates is not its only subject but all those whom Socrates accustomed to talk with (ἐκεῖνοι οἷς σὺ εἴωθας διαλέγεσθαι). This last phrase, I think, extends this critic beyond this dialogue to other Socratic dialogues. Hippias’ use of the perfect tense of the verb ἔθω (to be accustomed) is a good evidence of this extension. We can get, thus, these ἐκεῖνοι as Socrates’ interlocutors in his other dialogues that hints that this criticism has the epistemological groundings of the previous dialogues as its subject. What ἐκεῖνοι οἷς σὺ εἴωθας διαλέγεσθαι points to is that Hippias does not have in mind Socrates’ way of treating things only in this dialogue, but he is also criticizing Socrates’ way throughout his dialogues. At 301b4-5, Socrates and his interlocutors’ way of beholding things is described as such: -/- You people knock (κρούετε) at the fine and each of the beings (ἕκαστον τῶν ὄντων) by taking each being cut up in pieces (κατατέμνοντες) in words (ἐν τοῖς λόγοις). This leads us to our next principle that is parallel to, and the ontological side of, SK, the principle of 'Split Being'(SB): -/- SB Everything (being) is separated from any other thing as if the whole being is split to many beings. -/- Socrates and his interlocutors and thus, as we saw, the Socratic dialogues are accused to regard everything as it is separated from all other things. This separation is en tois logois that, I think, can reasonably be taken as saying that Socratic dialogues (it refers of course to the dialogues before Hippias Major) cut up all things which have the same name/definition from all other things and try to understand them separately, without considering other things that are not in their logos. They, for example in Hippias Major, are cutting up to kalon and try to understand what it and all others inside this logos are by separating it from all other things. This is directed straightly against Socratic question and the way Socratic dialogues follow to find its answer, every time separating one logos. As Meyer (1995, 85) points out, every question 'presupposes that the X in question in a logos is something' and 'every answer to every question aims at unity' (84). The critique of Hippias Major is, therefore, at the same time a critique of SK and SB. It is also a critique of KWX because it is only based on KWX that Socratic dialogues could search for the answer of 'what is X' question supposing that knowing what X is is enough for the knowledge of X. SK and KWX are absolutely interdependent. What Socrates and all his previous interlocutors have neglected in Socratic dialogues, Hippias says, was 'continuous bodies of being' (διανεκῆ σώματα τῆς οὐσίας) (301b6). Either this theory actually belongs to the historical Hippias as it is being said or not, it is strictly criticizing SB. We have the same phrase with changing sūma to logos some lines later at 301e3-4: διανεκεῖ λόγῳ τῆς οὐσίας. Although this theory that can be observed as both an ontological and an epistemological theory is rejected by Socrates (301cff.), it is still against first Socrates’ onto-epistemological principles and might let us look at what is rejected as Socratic prineple. -/- 6. Knowledge is of Being The sixth principle that I think is presupposed by the first Socrates, is the 'Knowledge of Being' Principle (KB): -/- KB Knowledge is of Being. -/- This principle is obviously the source of the problem of false knowledge, a very important problem throughout Plato’s philosophy. We face this problem maybe for the first time in Euthydemus. In less than 20 Stephanus’ pages, 276-295, we are encountered with different interwoven problems about knowledge , all grounded in the problem of false opinion. Having challenged the obvious possibility of telling lies at 283e, at 284 Euthydemus discusses it saying that the man who speaks is speaking about 'one of those things that are (ἓν μὴν κἀκεῖνό γ᾽ ἐστὶν τῶν ὄντων)' (284a3) and thus speaks what is (λέγων τὸ ὄν) (a5). He must necessarily be saying truth when he is speaking what is because he who speaks what is (τὸ ὄν) and the things that are (τὰ ὄντα) speaks truth (τἀληθῆ λέγει) (a5-6). This is based on Parmenidean principle of the impossibility of being of not being which Euthydemus restates (284b3-4) and we mentioned discussing BO principle above. The things that are not are nowhere (οὐδαμοῦ) and there is no possibility for anyone to do (πράξειεν) anything with them because they must be made as being before anything else can be done, which is impossible (b5-7). The words, then, are of things that exist (εἰσὶν ἑκάστῳ τῶν ὄντων λόγοι) (285e9) and as they are (ὡς ἔστιν) (e10). The result is that no one can speak of things as they are not. It is this impossibility of false speach that is extended to thinking (δοξάζειν) at 286d1 and leads to the impossibility of false opinion (ψευδής … δόξα) (286d4). The general conclusion is asserted at 287a extending this impossibility to actions and making any kind of mistake. Not only knowledge is of being but speech, thought and action are of being simply because of the fact that nothing can be of not being. -/- B. First Socrates’ Principles in the Middle Period Dialogues Out of what were presupposed or criticized mostly in five dialogues, Euthyphro, Euthydemus, Hippias Major, Laches and Charmides, we tried to draw the first Socrates’ principles. Our inquiry here is directed to find out the fate of these principles in the three dialogues of the middle period, Meno, Phaedo and Republic. To do this, first we ought to check the situation of Socratic circle in these dialogues. The Socratic circle that was predominant in the early dialogues, does not look like a circle here anymore though they certainly have some features in common. Meno, Phaedo and Republic II-X are not committed to the principles of the circle and the whole circle in disrupted in them. The difference of the two Socrateses towards acquiring knowledge is obvious. The Socrates of Meno, Phaedo and Republic is evidently more self-confident that he can get to some truths during his arguments as he does. They are in their first appearance, as almost all other dialogues, committed to Socrates’ disavowal. All of them try to keep the shape of the Socratikoi Logoi genre, which is committed to the historical Socrates’ way of discussion; a dramatic personage who is to challenge his interlocutors, ask them and refuse the answers. Nevertheless, the fact is that what we have in common between two groups of dialogues is mostly a dramatic structure. Whereas the first group’s arguments are based on Socrates’ disavowal and lead to no positive results, the second group is decisively going to achieve some positive results. The aim of the first Socrates was to show others that they are ignorant of what they thought they knew. The new Socrates of Meno, on the opposite, makes so much efforts to show that the slave boy has within himself true opinions (ἀληθεῖς δόξαι) about the things that he does not know (οἶδε) (85c6-7). Despite his lack of knowledge, he has true opinions nevertheless. The way from these true opinions to knowledge, as Socrates states, is not so long. These true opinions are now like a dream but 'can become knowledge of the same things not less accurate than anyone’s' (οὐδενὸς ἧττον ἀκριβῶς ἐπιστήσεται περὶ τούτων) (c11-d1), if they be repeated by asking the same questions. The most outstanding text regarding Socrates’ disavowal is Meno 98b where he explicitly claims knowledge: -/- And indeed I also speak as (ὡς) one who does not know (εἰδὼς) but is guessing (εἰκάζων). However, [about the fact] that true opinion and knowledge are different, I do not altogether expect (δοκῶ) myself to be guessing (εἰκάζειν), but if I say about anything that I know (εἰδέναι) -which about few things I say- this is one of the things that I know (οἶδα). (98b1-5) This passage is very significant about Plato’s disavowal of knowledge. There can hardly be found, I think, anywhere else in Plato’s corpus where Socrates speaks about his knowledge of something as such. He says first that he speaks as someone who does not know. This ὡς οὐκ εἰδὼς λέγω comparing with what he used to say in the first group, οὐκ οἶδα, has this added ὡς. Socrates does not claim strongly anymore that he does not know anything but speaks only as someone who does not know. He needs this ὡς not only because he is going to accept that he does know some, though few, things immediately after this sentence, but also because he needs his previous disavowal to be loosened from Meno on. He does not merely say here that he knows something. It is then different from the examples mentioned before which could be taken as idiomatic or at least not emphatic. Socrates’ remarkable emphasis on distinguishing εἰδέναι from εἰκάζειν departs it from all other passages where he says only he knows something. Moreover, he claims definitely that he has knowledge about few (ὀλίγα) things. From the early to the middle dialogues, Socrates’ attitude to knowledge has totally renewed its face. He brings forth a new concept, true opinion, and he does not speak of knowledge as he used to before; the rough, perfect and unachievable knowledge of the first group has turned to something more smooth, realistic and achievable. Comparing with the early dialogues that did not set out from the first to reach positive results, the middle ones are extraordinarily and surprisingly positive and hence destroy the basis of the Socratic circle. The questions and answers are purposely directed to some specific new theories; most of them are not directly related to the topics or the main questions of the dialogues. They are suggested when Socrates draws the attention of the interlocutor away from the main question because of the necessity of another discussion. Even if the main question remains unanswered, we have still many positive theories, prominently of metaphysical type. These theories are so abundant and dominant in these dialogues, especially Phaedo and Republic, that one might think that they may appear to be arbitrarily sandwiched in there. This helps dialogues to keep their original Socratic structure while they are suggesting new theories. Hence, the Socratic question of 'what is X?', though is still used to launch the discussion, is loosened and is forgotten for most part of the dialogues. Meno that has first a differently formulated question, 'can virtue be taught?', leads finally to the Socratic question of 'What is virtue?'. Phaedo is dedicated to the demonstration of the immortality of soul and the life after death without having a central Socratic question. The case of Republic is more complicated. The first book, on the one hand, has all the criteria of a Socratic circle: its 'what is justice?' question, Socrates’ strong disavowal (e.g. 337d-e), his rejection of all answers and coming back to the first point without finding out any answer. This Book, considered alone, is a perfect Socratic dialogue, as many scholars regard it as early and separated from other books. The books II-X are, on the other hand, far from implementing a Socratic circle. They have still the 'what is justice?' question as their incentive leading question, but they are, in most of the positive doctrines and methods that encompass the main parts, ignoring the question. Even these books that, I believe, are the farthest discussions from the Socratic circle are so cautious not to break the Socratic structure of the dialogue as long as it is possible. What is changed is not the structure of the dialogue but the ontological and epistemological grounds based on which new theories are suggested. -/- 1. Knowledge of the Good We can clearly see in the second group of dialogues that the KWX principle loses the place it had before in our first group. It is not, of course, rejected, but still we cannot say that it has the same situation. KWX that was based on Socratic question, as we discussed before, was the leading principle of the first Socrates’ epistemology and of the highest position. Other epistemological principles, SK directly and BE indirectly, were relying on Socratic question and therefore on KWX. Such a position does not belong to KWX from Meno on. What makes it different in the second Socrates is another principle that is needed it not only as its complementary principle but also as what is more fundamental. Plato, then, does not reject KWX in this period, but, it seems, he transcends to another more basic principle; a principle we shall call the principle of 'Knowledge of the Good' (KG): -/- KG Knowledge of X requires knowledge of the Good. -/- Whereas all the dialogues of our first group are free from any discuscon about KG, it bears a very important role in the second group so as becomes the superior principle of knowledge in Republic. Trying to solve the problem of teachability of virtue, Socrates says that it can be teachable only if it is a kind of knowledge because nothing can be taught to human beings but knowledge (ἐπιστήμην) (Meno 87c2). The dilemma will be, then, whether virtue is knowledge or not (c11-12) and since virtue is good, we can change the question to: whether is there anything good separate from knowledge (εἰ μέν τί ἐστιν ἀγαθὸν καὶ ἄλλο χωριζόμενον ἐπιστήμης) (d4-5). Therefore, the conclusion will be that if there is nothing good which knowledge does not encompass, virtue can be nothing but knowledge (d6-8). What let us discuss KG as an epistemological principle for the second Secrates is the relation he tries to establish between knowledge and the Good which, though is alongside with the mentioned thesis and the idea of virtue as knowledge, goes much deeper inside epistemology asking to regard the Good as the basis of knowledge. The effort of Phaedo cannot succeed in establishing the Good as the criterion of explanation and knowledge since, I think, it needs a far more complicated ontology of Republic where Socrates can finally announce KG. What is said in Republic is totally compatible with Phaedo 99d–e and the metaphor of watching an eclipse of the sun. In spite of the fact that we do not have adequate knowledge of the Idea of the Good, it is necessary for every kind of knowledge: 'If we do not know it, even if we know all other things, it is of no benefit to us without it' (505a6-7). The problem of our not having sufficient knowledge of the Idea of Good is tried to be solved by the same method of Phaedo 99d-e, that is to say, by looking at what is like instead of looking at thing itself (506d8-e4). It is this solution that leads to the comparison of the Good with sun in the allegory of Sun (508b12-13). What the Good is in the intelligible realm corresponds to what the sun is in the visible realm; as sun is not sight, but is its cause and is seen by it (b9-10), the Good is so regarding knowledge. It has, then, the same role for knowledge that the sun has for sight. Socrates draws our attention to the function of sun in our seeing. The eyes can see everything only in the light of the day being unable to see the same things in the gloom of night (508c4-6). Without the sun, our eyes are dimmed and blind as if they do not have clear vision any longer (c6-7). That the Good must have the same role about knowledge based on the analogy means that it must be considered as a required condition of any kind of knowledge: -/- The soul, then, thinks (νόει) in the same way: whenever it focuses on what is shined upon by truth and being, understands (ἐνόησέν), knows (ἔγνω) and apparently possesses understanding (νοῦν ἔχειν). (508d4-6) -/- Socrates does not use agathon in this paragraph and substitutes it with both aletheia and to on. He links them with the Idea of the Good when he is to assert the conclusion of the analogy: -/- That which gives truth to the objects of knowledge and the power of knowing to the knower, you must say, is the Idea of the Good: being the cause of knowledge and truth (αἰτίαν δ᾽ ἐπιστήμης οὖσαν καὶ ἀληθείας) so far as it is known (ὡς γιγνωσκομένης μὲν διανοοῦ). (508e1-4) Knowledge and truth are called goodlike (ἀγαθοειδῆ) since they are not the same as the Good but more honoured (508e6-509a5). KG, which had been implicitly contemplated and searched in Phaedo, is now explicitly being asserted in Republic. As what was quoted clearly proves, this principle is the very one which we can observe as the most fundamental principle of the second Socrates in Republic, corresponding to the role KWX had in the first Socrates. The Form of the Good in Republic, of which Santas speaks as 'the centerpiece of the canonical Platonism of the middle dialogues, the centerpiece of Plato’s metaphysics, epistemology, ethics and …' (1983, 256) much more can be said. Plato’s Cave allegory in Book VIII dedicates a similar role to the Idea of the Good. The Idea of the Good is there as the last thing to be seen in the knowable realm, something so important that its seeing equals to understanding the fact that it is the cause of all that is correct and beautiful (517b). Producing both light and its source in visible realm, it controls and provides truth and understanding in the intelligible realm (517c). -/- 2. Tripartite Epistemology BE is thoroughy rejected in the second Socrates and substituted by its opposite, the principle of 'Tripartite Epistemolgy' (TE): -/- TE Opinion is an epistemological status between knowledge and ignorance. BE of the first Socrates was denying any third way besides knowledge and ignorance which was the foundation of Socratic circle without which Socrates could not reject his interlocutors’ possessing any kind of knowledge. We cannot say, however, that the first Socrates had a third epistemological status in mind but rejected it. Such a status was unacceptable for him so that one can say that he would reject any kind of such status if suggested. There were only two possibilities about knowledge: either one knows something or he does not know it. TE, thus, was not the first Socrates’ discovery and, I think it is not the second Socrates’discovery. All we can see in our second group of dialouges is that he uses this principle as an already demonstrated one. Having examined the slave boy in Meno for the prupose of showing the working of recollection, it truns out that he has some opinions in him while he still does not know. Without trying to prove it, Socrates takes this as the distinction between knowledge and opinion: -/- So, he who does not know (οὐκ εἰδότι) about what he does not know (περὶ ὧν ἂν μὴ εἰδῇ) has within himself true opinions (ἀληθεῖς δόξαι) about the same things he did not know (περὶ τούτων ὧν οὐκ οἶδε) (85c6-7). -/- The same distinction is set between ὀρθὴν δόξαν and ἐπιστήμην at 97b5-6 ff. (also cf. 97b1-2: ὀρθῶς μὲν δοξάζων … ἐπιστάμενος). He connects then their difference to the myth of Daedalus, the statue that would run away and escape. So are true opinions, not willing to remain long in mind and thus not worthy until one ties them down by αἰτίας λογισμῷ (98a3-4). Socrates says that this tying down is anamnesis. We face, in Phaedo, the same relation is settled between knowledge as the process of being tied down and getting the capability to give an account, on the one hand, and anamnesis, on the other hand. When a man knows, he must be able to give an account of what he knows (Phaedo 76b5-6) and since not all people are able to give such an account, those who recollect, recollect what once they learned (76c4). Although the distinction between knowledge and opinion is not explicitly used in Phaedo, referring to the parallel link between knowledge plus account and anamnesis in Phaedo and Meno, one can say that those who cannot recollect are not able to give account and, thus, are in a state of opinion. What is said at Phaedo 84a, though not yet a definite distinction between knowledge and opinion, makes a distinction between their objects so as we can agree that it is presupposed. The soul of the philosopher, Socrates says, follows reason, stays with it forever and contemplates the divine, which is not the object of opinoin (ἀδόξαστον) (84a8, cf. Meno 98b2-5). The distinction of knowledge and belief in Republic has a significant difference with what we discussed in Meno and Phaedo since the distinction of Meno was based on anamnesis and thus more an epistemological distinction. Even in Phaedo that we do not have any elaborate discussion about the distinction, the only hint to the matter at 76 is bound to the theory of anamnesis. In addition to the relation of the distinction with this theory, there is another evidence that does not permit us to consider the distinction as an ontological distinction. Let’s see Meno 85c6-7: -/- So, he who does not know about what he does not know has within himself true opinions about the same things he did not know (τῷ οὐκ εἰδότι ἄρα περὶ ὧν ἂν μὴ εἰδῇ ἔνεισιν ἀληθεῖς δόξαι περὶ τούτων ὧν οὐκ οἶδε). (85c6-7) -/- This last sentence persists that the objects of knowledge and true opinion are the same. What Socrates is to say here is that whereas he does not know X he has true opinion about the same X. I think Socrates’ sentence that the slave boy οὐκ εἰδότι ἄρα περὶ ὧν ἂν μὴ εἰδῇ and his restatement of it by saying περὶ τούτων ὧν οὐκ οἶδε is because he wants to emphasize that the slave boy who does not know, has true opinion about the same thing. Socrates could say this just with using τούτων and there would be no necessity to bring περὶ ὧν ἂν μὴ εἰδῇ for οὐκ εἰδότι if he did not want to emphasize. -/- 3. Tripartite Ontology The distinction between knowledge and true opinion in Republic, on other side, has nothing to do with recollection, but is based on an ontological principle, 'Tripartite Ontology' (TO): -/- TO There are things that both are and are not. -/- This principle I confine, among our three dialogues of the second group, to Republic not extended to Meno and Phaedo, is obviously the opposite of BO. Speaking about the lovers of sights and sounds in the fifth book, Socrates distinguishes them from philosophers because their thought is unable to understand the nature of beautiful itself besides beautiful things (476a6-8) and hence they can only have opinions. The philosopher who, on the contrary, believes in beautiful itself and can distinguish it from beautiful things (476c9-d3), has knowledge because he knows, contrasting others who have opinion because they only opine (d5-6). Since those whose knowledge were degraded as opinion will complain about Socrates’ such calling their thought, he provides them the following argument (476e7-477b1): -/- - Does the person who knows, knows (γιγνώσκει) something (τὶ) or nothing (οὐδέν)? - He knows something (τί). - Something that is (ὂν) or is not (οὐκ ὄν)? - Something that is (ὂν) for how could something that is not be known (πῶς γὰρ ἂν μὴ ὄν γέ τι γνωσθείη)? - Then we have an adequate grasp of this: No matter how many ways we examine it, what completely is (παντελῶς ὂν) is completely knowable (παντελῶς γνωστόν) and what is in no way (μὴ ὂν δὲ μηδαμῇ) is in every way unknowable (πάντῃ ἄγνωστον). - A most adequate one. - Good. Now, if anything is such as to be and also not to be (ὡς εἶναί τε καὶ μὴ εἶναι), won’t it be intermediate (μεταξὺ) between what purely is (εἰλικρινῶς ὄντος) and what in no way is (μηδαμῇ ὄντος)? - Yes, it’s intermediate. - Then as knowledge (γνῶσις) is set over what is (τῷ ὄντι), while ignorance (ἀγνωσία) is of necessity set over what is not (μὴ ὄντι) mustn’t we find an intermediate between ignorance (ἀγνοίας) and knowledge (ἐπιστήμης) to be set over the intermediate, if there is such a thing? -/- From the third status of being we must reach to the third status of knowledge. The simple reading of this text can be an existential reading, taking the "is" of the mentioned sentences as existence. The problem is that when it is said that there is something that both is and is not reading "is" existentially, it sounds too bizarre to be acceptable. It cannot easily be understandable to have something as both existent and non-existent at the same time. This problem arose so many debates and led many scholars to reject the existential reading of "is" and suggest some other readings like predicative or veridical readings. I think though Plato’s complicated ontology of Republic cannot be correctly understood by a simple existential reading, this "is" cannot be free from existential sense of being and, thus, cannot be reduced to just a predicative or veridical sense of being. -/- 4. Bound Knowledges In addition to KG, the Good is also the basis of another principle in the second Socrates, namely the principle of 'Bound Knowledge' (BK): -/- BK Knowledge of everything is bound to the knowledge of the Good. -/- We distinguished BK from KG because we want to insist, in BK, on what had not been insisted upon in KG, that is, the binding role that the Good plays in the second Socrates, contrasting the absence of such a role in the first Socrates. Socrates remembers, in Phaedo, his wonderful keen on natural philosophers' wisdom when he was young. The origin of this enthusiasm was Socrates’ hope to know the cause of everything as they used to claim. When he was searching the matters of his interest on their basis, Socrates says, he became convinced he can get no acceptable answer from them and found himself blind even to the things he thought he knew before. One day he hears Anaxagoras’ theory that 'it is Mind that arranges and is the cause of everything (ὡς ἄρα νοῦς ἐστιν ὁ διακοσμῶν τε καὶ πάντων αἴτιος)' (Phd. 97c1-2 cf. DK, Fr.15.8-9, 11-12, 12-14) and thinks that he can finally find what he has always expected, i.e. something which can explain all things. What I intend to show here is that what makes Socrates hopeful is that Anaxagoras’ theory tries 1) to explain all things by one thing and 2) this explanation is understood by Socrates as if it is based on the concept of the Good. That Socrates was searching for one explanation for all things can be proved even from what he has been expecting from natural philosophers. The case is, nonetheless, more clearly asserted when he speaks about Anaxagoras’ theory. In addition to διακοσμῶν τε καὶ πάντων αἴτιος of 97c2 mentioned above, we have τὸ τὸν νοῦν εἶναι πάντων αἴτιον (c3-4) and τόν γε νοῦν κοσμοῦντα πάντα κοσμεῖν (c4-5) all emphasizing on the cause of all things (πάντα) which can clearly prove that one of the reasons which caused Socrates to embrace it delightfully was its claim to provide the cause of all things by one thing. Another reason was that Anaxagoras’ Mind, at least in Socrates’ view, was attempting to explain everything by the concept of the Good. This connection between Mind and Good belongs more to the essential relation they have in Socrates’ thinking than Anaxagoras’ theory because there are almost nothing about such a relation in Anaxagoras. The reason for Socrates’ reading can be that Mind is substantially compatible with Socrates’ idea of the relation between good and knowledge. Both the thesis 'no one does wrong willingly' and the theory of virtue as knowledge we pointed to above are evidences of this essential relation. Nobody who knows that something is bad can choose or do it as bad. The reason, when it is reason, that means when it is as it should be, when it is wise or when it knows, works only based on good-choosing. In this context, when Socrates hears that Mind is considered as the cause of everything, it sounds to him like this: good should be regarded as the basis of the explanation of all things. We see him, thus, passing from the former to the latter without any proof. This is done in the second sentence after introducing Mind: -/- I thought that if this were so, the arranging Mind would arrange all things and put each thing in the way that was Best (ὅπῃ ἂν βέλτιστα ἔχῃ). If one then wished to find the cause of each thing by which it either perishes or exists, one needs to find what is the best way (βέλτιστον αὐτῷ ἐστιν) for it to be, or to be acted upon, or to act. On these premises then it befitted a man to investigate only, about this and other things, what is the most excellent (ἄριστον) and best (βέλτιστον). The same man must inevitably also know what is worse (χεῖρον), for that is part of the same knowledge. (97c4-d5) This passage is a good evidence of Socrates’ leap from Anaxagoras’ Mind to his own concept of the Good that can explain why Socrates found Anaxagoras theory after his own heart (97d7). Mind is welcomed because of its capability for explanation on the basis of good to 'explain why it is so of necessity, saying which is better (ἄμεινον), and that it was better (ἄμεινον) to be so' (97e1-3). What Socrates thought he had found in Anaxagoras can indicate what he had been expecting from natural scientists before. Socrates could not be satisfied with their explanations because they were unable to explain how it is the best for everything to be as it is. It can probably be said, then, that it was the lack of the unifying Good in their explanation that had disappointed him. We must insist that we are discussing what Socrates thought that Anaxagoras’ theory of Mind should have been, not about Anaxagoras’ actual way of using Mind. Phaedo 97c-98b, is not about what Socrates found in Anaxagoras but what he thought he could find in it. On the contrary, it should also be noted that it was not this that was dashed at 98b, but Anaxagoras’ actual way of using Mind. It was Anaxagoras’ fault not to find out how to use such an excellent thesis (98b8-c2, cf. 98e-99b). Socrates gives an example to show how not believing in 'good' as the basis of explanation makes people be wanderers between different unreal explanations of a thing. His words δέον συνδεῖν (binding that binds together) as a description for the Good we chose as the name of BK principle: They do not believe that the truly good and binding binds and holds them together (ὡς ἀληθῶς τὸ ἀγαθὸν καὶ δέον συνδεῖν καὶ συνέχειν οὐδὲν οἴονται). (99c5-6) -/- Having in mind Plato’s well-known analogy of the sun and the Good at Republic 508-509, we can dare to say that his warning of the danger of seeing the truth directly like one watching an eclipse of the sun in Phaedo (99d-e) is more about the difficulty of so-called good-based explanation than its insufficiency, a difficulty which is precisely confirmed in Republic (504e-505a, 506d-e). Moreover, BK is asserted in a more explicit way in the Republic, where the Good is considered not only as a condition for the knowledge of X, as was noted above discussing KG, but also as what binds all the objects of knowledge and also the soul in its knowing them. At Republic VI, 508e1-3, when Socrates says that the Form of the Good 'gives truth to the things known and the power to know to the knower (τοῦτο τοίνυν τὸ τὴν ἀλήθειαν παρέχον τοῖς γιγνωσκομένοις καὶ τῷ γιγνώσκοντι τὴν δύναμιν ἀποδιδὸν)', he wants to set the Good at the highest point of his epistemological structure by which all the elements of this structure are bound. This binding aspect of the Good is by no means a simple binding of all knowledges or all the objects of knowledge, but the most complicated kind of binding as it is expected from the author of the Republic. The kind of unity the Good gives to the different knowledges of different things is comparable with the unity which each Form gives to its participants in Republic: as all the participants of a Form are united by referring to the ideas, all different kinds of knowledge are united by referring to the Good. If we observe Aristotle's assertion that for Plato and the believers of Forms, the causative relation of the One with the Forms is the same as that of the Forms with particulars (e.g. Metaphysics 988a10-11, 988b4), that is to say the One is the essence (e.g., ibid, 988a10-11: τοῦ τί ἐστὶν, 988b4-6: τὸ τί ἢν εἶναί) of the Forms besides his statement that for them One is the Good (e.g., ibid, 988b11-13) the relation between the Good and unity may become more understandable. Since the quiddity of the Good (τί ποτ᾽ ἐστὶ τἀγαθὸν) is more than discussion (506d8-e2), we cannot await Socrates to tell us how this binding role is played. All we can expect is to hear from him an analogy by which this unifying role is envisaged, the sun. The kind of unity that the Good gives to the knowledge and its objects in the intelligible realm is comparable to the unity that the sun gives to the sight and its objects in the visible realm (508b-c). The allegory of Line (Republic VI, 509d-511), like that of the Sun, tries to bind all various kinds of knowledges. The hierarchical model of the Line which encompasses all kinds of knowledge from imagination to understanding can clearly be considered as Plato’s effort to bind all kinds of knowledges by a certain unhypothetical principle. The method of hypothesis starts, in the first subsection of the intelligible realm, with a hypothesis that is not directed firstly to a principle but a conclusion (510b4-6). It proceeds, in the other subsection, to a 'principle which is not a hypothesis' (b7) and is called the 'unhypothetical principle of all things' (ἀνυποθέτου ἐπὶ τὴν τοῦ παντὸς ἀρχὴν) (511b6-7). This παντὸς must refer not only to the objects of the intelligible realm but to the sensible objects as well. Plato does posit, therefore, an epistemological principle for all things, a principle that all things are, epistemologically, bound and, thus, unified by. -/- 5. Bound Beings The ontological aspect of BK we shall call the principle of 'Bound Beings' (BB): -/- BB Being of all things are bound by the Good. -/- We saw in our principle of Split Being (SB) how the first Socrates was criticized because of his approach to split being and separate each thing from other things. The principle of Bound Beings intends to make the things more related, a duty which is done again by the Good. In the allegory of Sun, there are two paragraphs that evidently and deliberately extend the binding role of the Good to the ontological scene: -/- You will say that the sun not only makes the visible things have the ability of being seen but also coming to be, growth and nourishment. (509b2-4) -/- This clearly intends to remind the ontological role the sun plays in bringing to being all the sensible things in order to display how its counterpart has the same role in the intelligible realm (b6-10): -/- Not only the objects of knowledge (γιγνωσκομένοις) owe their being known (γιγνώσκεσθαι) to the Good, but also their existence (τὸ εἶναί) and their being (οὐσίαν) are due to it, though the Good is not being but superior to it in rank and power. That the Good is here represented as responsible for being of things in addition to their being known means, in my opinion, that Plato wants to posit BB in addition to BK. The allegory of Cave at the very beginning of the seventh Book (514aff.) can be taken as another evidence. The role of the Good, one might say, is confined to the intelligible realm because it is asserted that the role the Good plays in this realm is corresponding to that of the sun in the visible realm. The fact that Plato wants to observe the Good also as the ontological cause of the sensible things is obvious from his saying, in the allegory of Cave, that the Form of the Good 'produces light and its source (τὸν τούτου κύριον) [i.e. the sun] in the visible realm' (517c3). We can conclude, then, that the ontological function of the Good is not confined to the intelligible realm in which it is the lord and provides truth and understanding (c3-4) because it is also responsible to produce τὸν κύριον of light. 6. Proportionality of Being and Knowledge Insofaras BE and BO principles of the first Socrates gave way to TE and TO principles of the second Socrates, we cannot expect him to preserve KB in the same way as it was in the first Socrates. The new tripartite ontology and epistemology necessitates some modifications in KB which results in the principle of 'Proportionality of Being and Knowledge' (PBK): -/- PBK To every class of being there is a proportionate category of knowledge. -/- This principle, of course, does not entail the refutation of KB and thus is not kind of rejecting PBK but only a more complicated version of it. Based on PBK, we can still agree that knowledge is of being (KB) but the issue is that since none of the concepts of knowledge and being in the second Socrates are as simple as they were for the first Socrates, we need a more complicated principle for their relation here. Although from Meno 97a where the distinction of knowledge and true opinion is drawn out in the second group of the dialogues, we can expect a new relation, it is articulated in its most complete way in Republic and specifically in the allegory of Line. All the beings are divided there hierarchically to four classes, to each of them belongs a class of knowledge: imagination to images, belief to the sensible things (more correctly: the things of which they[in previous class] were images (ᾧ τοῦτο ἔοικεν)), thought to mathematical objects (?) and understanding to the Forms and the first principle. The degree of clarity that each of the classes of knowledge shares in (σαφηνείας ἡγησάμενος μετέχειν) is proportionate to the degree that its object shares in truth (ἀληθείας μετέχει). (511e2-4) -/- Conclusion From the six onto-epistemilogical principles of the first Socrates, four principles turn to their opposite in the middle period dialogues. While bipolar epistemology and ontology of the early dialogues give place to tripartite epistemology in the middle period dialogues and tripartite ontology in Republic, the split knowledge and being of the first Socrates are inclined to be substituted by bound knowledges and bound beings in the second Socrates and specifically in Republic. Not all our system of principles in this article is necessarily determinative. Either they are rightly formulated or not, our result would not be vulnerable if we accept that 1) making the distinction of knowledge and belief, 2) accepting the being of not being and 3) trying to bind both being and knowledge by the concept of the Good happens only in middle period dialogues, having been absent in the early ones. These are the favourite results all those somehow arbitrary and even oversimplified principles were to illustrate; that there is kind of a development in the epistemological as well as the ontological grounds of Plato’s philosophy. -/- Notes . (shrink)

GAMETOGÊNESE -/- Emanuel Isaque Cordeiro da Silva Instituto Agronômico de Pernambuco Departamento de Zootecnia – UFRPE Embrapa Semiárido -/- • _____OBJETIVO -/- Os estudantes bem informados, estão a buscando conhecimento a todo momento. O estudante de Veterinária e Zootecnia, sabe que a Reprodução é uma área de primordial importância para sua carreira. Logo, o conhecimento da mesma torna-se indispensável. No primeiro trabalho da série fisiologia reprodutiva dos animais domésticos, foi abordado de forma clara, didática e objetiva os mecanismos de diferenciação (...) sexual dos embriões em desenvolvimento, quais os genes envolvidos nesse processo e tudo mais. Nesse segundo trabalho, a abordagem será teórica, mas também clara, sobre a formação primordial dos gametas femininos e masculinos, através da ovogênese nas fêmeas e a espermatogênese nos machos. Esse trabalho visa levar a importância do processo de formação dos gametas e a produção hormonal das gônadas, bem como o entendimento sobre as interações com o eixo hipotálamo-hipofisário. -/- •____INTRODUÇÃO -/- A reprodução sexual é um processo mediante a qual dois organismos da mesma espécie unem seu material genético para dar lugar a um organismo fixo com combinação única de genes; para isso, cada organismo produz células que contém a metade do material genético característico da espécie. Essas células haploides (1n) são denominadas gametas; ao combinar-se um gameta masculino com um feminino produz-se uma célula diploide (2n) (zigoto ou ovo) a partir da qual se forma o embrião. A grande maioria das espécies com reprodução sexual são anisogâmicas, o que significa que produzem dois tipos de gametas diferentes: os gametas masculinos são microscópios, móveis e produzem-se em grande quantidade, enquanto que os femininos são grandes, imóveis e produzem-se em menor quantidade. O tipo de gameta que um indivíduo produz é o que define seu sexo; sobre os animais o macho é o indivíduo que produz grandes quantidades de espermatozoides e a fêmea produz uma menor quantidade de óvulos, enquanto que nas plantas as gônadas masculinas são as produtoras pólen e as femininas produzem oosferas. Os gametas são diferentes do resto das células do organismo, as quais se chamam células somáticas; essas últimas são diploides porque contém dois pares de cromossomos, um par herdado do pai do indivíduo e o outro da mãe. As células somáticas, ademais, se dividem por mitose, ao qual os cromossomos se duplicam antes de cada divisão celular e cada uma das células filhas recebe um complemento diploide idêntico dos cromossomos, logo todas as células somáticas de um indivíduo possuem o mesmo material genético, embora cada tipo celular expresse diferentes combinações de genes. Em contraponto, os gametas são células haploides porque possuem somente um par de cromossomos e a metade do material genético característico da espécie. Cada um dos cromossomos em um gameta é resultado da recombinação dos genes contidos nos cromossomos paterno e materno do indivíduo que originam o gameta, e cada um destes possuem uma combinação única de genes. Os gametas se formam a partir das células germinais, que são células que em sua origem são diploides e elas de “comprometem” a manter-se como uma linha celular especial que em determinado momento sofrerá o processo de meiose para dar origem aos gametas haploides, sejam óvulos ou espermatozoides segundo o sexo do animal. Como descrito no trabalho sobre a diferenciação sexual, as células germinativas primordiais originam-se no epiblasto do embrião, e migram desde o saco vitelino até colonizar as cristas gonodais, onde, por sua vez, proliferam-se e se organizam junto com as células somáticas da gônada primitiva para formar o testículo ou o ovário. As células germinais masculinas e femininas tem a mesma origem embrionária. As gônadas indiferenciadas em um embrião possuem três tipos celulares: as células que dão origem aos gametas (ovogonia ou espermatogonia), as precursoras de células que nutrem os gametas em desenvolvimento (células da granulosa no ovário; células de Sertoli no testículo) e as precursoras de células que secretam hormônios sexuais (células da teca no ovário; células de Leydig no testículo). As células germinais são as únicas estruturas do organismo que têm a capacidade de dividir-se por meiose sofrendo uma redução no número de seus cromossomos, sendo responsável pela transmissão da carga genética aos descendentes. Em contraste, as células somáticas somente se dividem por mitose. A formação dos gametas compreende fases sequenciais de mitose, meiose e pós-meiose. Esses processos são altamente organizados e necessitam de um preciso e bem coordenado programa de expressão genética. Uma das características importantes da gametogênese é a redução cromossômica, que através da meiose, reduz pela metade o número de cromossomos e produz células distintas entre si, devido a trocas de material genético entre os pares de cromossomos provenientes do pai e da mãe, o que ocorre no processo de “crossing over” durante a primeira fase da meiose. A gametogênese é o processo mediante o qual as células germinais de cada sexo se multiplicam, dividem e diferenciam até formar os gametas. No caso da formação dos gametas masculinos o processo recebe o nome específico de espermatogênese, e para os gametas femininos é denominado como ovogênese. Embora os dois processos alcancem o objetivo comum de produção das células haploides, por onde compartilham algumas características, existem diferenças marcadas entre eles devido a necessidade de produzir um número muito distinto de gametas, de tamanho diferente, e com características de motilidade também distintas. -/- •___ESPERMATOGÊNESE -/- A espermatogênese é o processo mediante o qual se produz os gametas masculinos denominados espermatozoides. Durante a vida fetal as células germinais e as células somáticas do testículo em formação organizam-se em túbulos seminíferos que se derivam dos cordões sexuais primários e conformam a maior parte da medula do testículo. Na etapa fetal cada tubo seminífero é delimitado por uma membrana basal, recoberta na parte interior pelas células precursoras das células de Sertoli (um tipo de células somáticas). No exterior do túbulo localizam-se as células precursoras das células de Leydig ou intersticiais (figura 1), que também são células somáticas. Entre a membrana basal e as células de Sertoli encontram-se algumas células germinais denominadas espermatogonias de reserva A0 (denominadas gonócitos) que serão o único tipo de células germinais presentes no testículo enquanto o animal não alcançar a puberdade. As células de Sertoli estabelecem na região basal uniões oclusoras entre si, formando parte da barreira hemato-testicular. As espermatogonias A0 localizam-se por dentro da membrana basal do túbulo seminífero, embora fora da barreira hemato-testicular. Figura 1: fase neonatal. Nota-se a grande infiltração de tecido intersticial em quase 50% da seção originando que os túbulos sejam pequenos e redondos em sua maioria. O citoplasma e núcleo das células pré-Leydig são notadas claramente por essa ser uma espécie suína onde o tecido intersticial está claramente diferenciado. Hematoxilina-eosina (X 220.5). Fonte: Embrapa. -/- O número de células de Sertoli no testículo depende da influência do hormônio folículo estimulante (FSH) presente durante a vida fetal e as primeiras etapas de vida pós-natal. A população de células de Sertoli ao chegar a puberdade se manterá fixa durante o resto da vida do animal; existe uma relação positiva entre o tamanho e a população de células de Sertoli e a capacidade de produção de espermatozoides do testículo. As células de Sertoli são as únicas células somáticas que estão no epitélio seminífero, e sua função é a nutrição, sustentação e controle endócrino das células germinais. As células de Sertoli participam ativamente no processo de liberação dos espermatozoides para a luz do túbulo. Nesse momento, as células de Sertoli realizam a fagocitose de parte do citoplasma do espermatozoide dos chamados corpos residuais. As células de Sertoli também fagocitam as células germinais que se degeneram no curso normal da espermatogênese. Essas células ainda sintetizam grande quantidade de proteínas, como por exemplo as proteínas ABP (androgen hinding protein), que transportam andrógenos para todo o aparelho reprodutivo, transferrinas, que transportam ferro para a respiração celular das células germinais e também às inibinas, que regulam a liberação de FSH pela hipófise, através de um sistema de retroalimentação (feedback) negativa (figura 2). Figura 2: epitélio seminífero, células de Sertoli (flecha) (400 X). Fonte: Embrapa. -/- Antes da puberdade dos túbulos seminíferos observam-se ao corte como estruturas de diâmetro pequeno, sem luz, e conformados unicamente pelas células de Sertoli e espermatogonias de reserva e rodeados por abundante tecido intersticial, ao que estão presentes as células precursoras das células de Leydig. Ainda antes da puberdade, a diferenciação celular manifesta-se primeiro pela presença de espermatócitos primários, os quais se degeneram em geral na fase de paquíteno, por falta de estimulação hormonal. A partir de que o animal chega a puberdade inicia-se o processo de espermatogênese, que se manterá durante toda a vida do animal, exceto em espécies de animais silvestres muito estacionais, ao qual pode se suspender durante a época não reprodutiva para voltar e ser retomada na época ou estação reprodutiva. Depois da puberdade, os túbulos seminíferos possuem um diâmetro muito maior; em seu interior observa-se um grande número de células germinais de todos os tipos, diferentes estádios de divisão, e em seu lúmen contém líquido e espermatozoides. Ainda sobre o alcancei da puberdade, as espermatogonias começam a dividir-se aceleradamente por mitose, enquanto que no espaço intersticial as células mesenquimais também começam a se diferenciar e a dar origem as células de Leydig (figura 3). A partir dessa etapa as células de Leydig (totalmente diferenciadas) são também evidentes no exterior do túbulo, junto com as células mioides ou peritubulares que o rodeiam o que ao contrair-se são responsáveis por controlar o avanço dos fluidos e as células presentes no lúmen do túbulo. As células mioides estão situadas ao redor do túbulo, e é creditado a elas a promoção da contração e da integridade estrutural do túbulo. Esse tipo celular apenas se diferencia na puberdade pela ação dos andrógenos (figura 4). As interações entre as células de Sertoli e as mioides parecem ter um papel importante na manutenção das funções do testículo. Durante o processo de espermatogênese, as espermatogonias de reserva dividem-se periodicamente e enquanto algumas células fixas permanecem como espermatogonias de reserva, outras proliferam e sofrem uma seção de divisões mitóticas durante as quais se vão diferenciando até formarem espermatócitos primários (espermatocitogênese ou fase de mitose), logo sofrem divisões especiais mediante as quais reduzem seu número de cromossomos (fase de meiose), e ao final trocam de forma para converter-se em espermatozoides (espermatocitogênese) (figura 5). Cada uma dessas etapas da espermato- gênese será descrito detalhadamente adiante, antes é necessário a explicação de algumas características das células de Sertoli e de Leydig que ajudarão a entender seu papel durante a espermatogênese. Figura 3: células de Leydig no espaço intersticial do testículo bovino adulto PAS (400 X). Fonte: Embrapa. -/- Figura 4: o estabelecimento da puberdade pela presença de espermatozoides no túbulo. Hematoxilina-eosina (400 X). Fonte: Embrapa. Figura 5: fases mitóticas das espermatogonias (A0 e B) para formação de um espermatócito primário e as duas fases de meiose que se sucedem antes da espermatogênese. Fonte: ZARCO, 2018. -/- Ao início da espermatocitogênese as uniões oclusoras entre as células de Sertoli se abrem por etapas (como as comportas de um submarino) para permitir a passagem das espermatogonias em direção ao centro do túbulo seminífero sem que se estabeleça uma continuidade entre o exterior e o interior da barreira hemato-testicular. Uma vez ultrapassada essa barreira, as sucessivas gerações de espermatogonias, espermatócitos, espermátides e espermatozoides irão se localizar em direção ao interior do túbulo seminífero, em estreita associação com as células de Sertoli. Em consequência, as células de Sertoli dividem o túbulo seminífero em dois compartimentos; o compartimento basal (debaixo das uniões oclusoras das células de Sertoli), ao qual residem as espermatogonias de reserva, e o compartimento adluminal (em direção ao centro do túbulo), cujos espaços entre as células de Sertoli desenvolvem o resto do processo de espermatogênese (meiose e espermatocitogênese). Esse feito é importante porque durante a vida fetal as únicas células germinais existentes eram as espermatogonias de reserva, pelo que os antígenos expressados por gerações mais avançadas (espermatogonias intermediárias, secundárias, espermátides e espermatozoides) não são reconhecidos como próprios do corpo pelo sistema imunológico. Logo, o anterior implica que deve existir uma barreira entre eles e o sangue para evitar um ataque imunológico. Em todas as etapas da espermatogênese, as células de Sertoli atuam como células de suporte para as células germinais, que sempre permanecem recoberta pela membrana das células de Sertoli. Também atuam como células nutricionais já que proporcionam o meio em que as células germinais se desenvolvem e maturam, assim como as substâncias que regulam e sincronizam as sucessivas divisões e transformações das células germinais. As células de Sertoli produzem hormônios, como estrógenos e inibina que atuam sobre a hipófise para regular a secreção das gonadotropinas que controlam a espermatogênese. As células de Leydig que residem no exterior do túbulo seminífero também são importantes para a espermatogênese: produzem a testosterona que estimula e mantém a espermatogênese, bem como serve como substrato sobre o qual atua como aromatizador das células de Sertoli para transformá-las em estrógenos. Como supracitado, para seu estudo podemos dividir a espermatogênese em três fase: espermatocitogênese, meiose e espermiogênese (figura 6). Agora, serão descritas cada uma dessas etapas. Em algumas espécies, incluindo no homem, os macrófagos representam o segundo tipo celular intersticial mais numeroso no testículo, depois das células de Leydig. Os macrófagos e vários subtipos de linfócitos são identificados nós testículos de ovinos e ratos. Eles estão intimamente associados com as células de Leydig e atuam juntamente na regulação da esteroidogênese. Figura 6: fluxograma da espermatogênese. -/- Espermatocitogênese -/- A espermatocitogênese, também chamada de etapa proliferativa ou de mitose, consiste numa série de divisões mitóticas sofridas pelas células descendentes de uma espermatogonia de reserva. Uma vez que a célula se divide, abandona o estado de reserva e começa um processo de diferenciação. As espermatogonias de reserva (denominadas espermatogonias A0 na rata ou As nos humanos) são células que existem desde a vida fetal e que permanecem mitoticamente inativas durante a infância. Uma vez que alcançam a puberdade começam a dividir-se em intervalos regulares, e as células filhas podem permanecer como espermatogonias de reserva ou abandonar a reserva e ingressar na dita espermatocitogênese. Uma vez abandonada a reserva, as células filhas que vão se formando em cada divisão permanecem unidas por pontes citoplasmáticas, constituindo um clone que se divide sincronicamente. As células que se formam depois de cada divisão continuam sendo espermatogonias, porém cada geração é ligeiramente diferente da anterior. Na rata, por exemplo, as espermatogonias tipo A0 ao dividir-se originam espermatogonias do tipo A1, que em sucessivas divisões formam espermatogonias dos tipos A2, A3 e A4, as quais, por sua vez, sofrem outra mitose para formar espermatogonias intermediárias e uma mais para formar espermatogonias do tipo B. Essas últimas se diferenciam (sem se dividir) em espermatócitos primários, processo em que termina a fase de espermatocitogênese, que literalmente significa processo de geração de espermatócitos. As espermatogonias tipo A0 são a fonte para a contínua produção de gametas. A metade delas se dividem e formam células iguais (as chamadas células tronco) e a outra metade forma as espermatogonias A1, que sofre novas divisões mitóticas e formam os tipos 2, 3 e 4. O tipo A4 sofre mitose para formar a intermediária (A In), que por mitose, forma a tipo B (figura 6). Esses tipos de espermatogonias podem ser identificadas em evoluções histológicas de acordo com sua organização topográfica na membrana basal dos túbulos seminíferos ou mediante seu conteúdo de heterocromatina. Outra maneira de diferenciação se baseia em marcadores moleculares específicos que distinguem as espermatogonias tronco (A0) das demais, com os fins de isolamento, desenvolvimento in vitro e transplante. As tipo B passam por mitose para formarem os espermatócitos primários; estes iniciam a primeira etapa da meiose formando os espermatócitos secundários; na segunda etapa da divisão meiótica, cada espermatócito secundário se divide e formam as chamadas espermátides. Quando o testículo alcança seu desenvolvimento total, a meiose completa-se e as espermátides originadas se convertem em espermatozoides. Um dos maiores sinais característicos desse fenômeno é o alargamento das espermátides e sua migração em direção ao lúmen do túbulo seminífero (figuras 4, 7 e 8). Figura 7: espermatogonias marcadas por imuno-histoquímica, anticorpo monoclonal TGFa (400 x). Figura 8: fases de divisões meióticas (M), espermatócitos em paquíteno (PA) e espermatócitos secundários (ES). -/- Figura 9: estádio posterior a liberação dos espermatozoides na luz do túbulo. Hematoxilina-eosina (400 x). Mediante as seis divisões mitóticas que ocorrem durante a espermatocitogênese se forma potencialmente um clone de 64 espermatócitos primários a partir de cada espermatogonia A que ingressa sobre o processo. Não obstante, algumas células sofrem apoptose em cada uma das etapas do processo, ao qual o número real formado é menor. Em outras espécies produzem-se um transcurso similar de divisões mitóticas sucessivas durante a espermatocitogênese, embora a nomenclatura utilizada possa ser distinta, por exemplo nos bovinos as duas últimas divisões mitóticas dão origem as espermatogonias de tipo B1 e B2. -/- Meiose -/- Uma vez que as espermatogonias B se diferenciam em espermatócitos primários, esses iniciam a etapa de meiose, com uma nova divisão; desta vez a divisão é do tipo meiótica. Ao completar-se a primeira divisão meiótica (meiose I) se obtém os espermató-citos secundários, que ao sofrer a segunda divisão meiótica (meiose II) dão origem as espermátides. Vale salientar que a meiose é o processo mediante o qual reduz-se a metade do número de cromossomos, pelo que as espermátides que se obtém são células haploides (1n). Os espermatócitos secundários que se formam depois da primeira divisão meiótica contém a metade do número normal de cromossomos, porém a mesma quantidade de DNA já que cada cromossomo é duplo. As espermátides formadas na conclusão da segunda divisão meiótica (figura 7), por sua vez, contém a metade dos cromossomos, e esse já não são duplos, já que se trata de células 1n. Também deve-se enfatizar que durante a meiose é relevante o entrecruzamento dos cromossomos homólogos, pelo que cada espermátide possui uma combinação única e diferente de genes paternos e maternos. Outro ponto que deve ser levado em consideração é que cada espermátide somente possui um cromossomo sexual; a metade das espermátides contém o cromossomo X herdado da mãe do macho que está levando a cabo a espermatogênese e a outra metade contém o cromossomo Y herdado de seu pai. Para cada espermatócito primário que entra no processo de meiose obtém-se cerca de quatro espermátides, pelo qual ao ser completada a meiose potencialmente se poderiam formar até 256 espermátides por cada espermatogonia que abandona a reserva e ingressa na espermatocitogênese. -/- Espermiogênese -/- Durante a espermiogênese, também chamada de fase de diferenciação, as esper-mátides sofrem, sem se dividir, uma metamorfose que as transforma em espermatozoides, os quais finalmente são liberados das células de Sertoli em direção ao lúmen do túbulo seminífero. A espermiogênese é um processo complicado e longo já que a espermátide deve sofrer complexas trocas nucleares, citoplasmáticas e morfológicas que resultam na forma-ção dos espermatozoides. Algumas dessas mudanças incluem a condensação do material nuclear para formação de um núcleo plano e denso, a eliminação do citoplasma para a constituição de uma célula pequena, a formação de uma estrutura especializada denomi-nada acrossomo ou tampa cefálica, e a formação do pescoço e da cauda (flagelo) do esper-matozoide, do que depende a sua motilidade. Durante a maior parte da espermiogênese, as espermátides se mantém com uma estreita associação com as células de Sertoli; logo, chega-se a observar, então, flagelos que se projetam em direção a luz do túbulo que pare-cem sair das células de Sertoli, sendo na realidade os flagelos dos espermatozoides que ainda não tinham sido liberados pelo lúmen. Ao liberar os espermatozoides em direção a luz do túbulo, as células de Sertoli realizam a fagocitose de parte do citoplasma dos espermatozoides (corpos residuais). Também fagocitam os restos de todas as células germinais que sofrem apoptose ou degeneram-se durante a espermatogênese. Credita-se que ao realizar essas funções as células de Sertoli podem fazer uma monitoração eficiente da espermatogênese, o que lhes permitiria emitir sinais para colaborar na regulação desse processo em nível gonodal e a nível sistêmico através da secreção de hormônios como a inibina e o estradiol. Além da inibina e activina, as células de Sertoli sintetizam outras proteínas, como a ABP (proteína ligadora de andrógenos) que serve como uma molécula de transporte de andrógenos dentro dos túbulos seminíferos, ductos deferentes e epidídimo, ou a transfer-rina, que transporta o ferro necessário para a respiração celular. -/- Resultados da espermatogênese -/- O resultado da espermatogênese não significa apenas uma simples multiplicação das células germinais (até 256 espermatozoides a partir de cada espermatogonia A1), senão que através dela são produzidos gametas haploides pequenos, móveis e com grande diversidade genética entre eles, ao mesmo tempo que se mantêm uma reversa de células mãe (espermatogonias A0) a partir das quais se poderiam originar novos ciclos de esper-matogênese durante o resto da vida do animal. -/- Controle hormonal da espermatogênese -/- Como mencionado, o FSH reproduz um importante papel para o estabelecimento das células de Sertoli durante a vida fetal e início da vida pós-natal. O começo da esper-matogênese também é estimulado pelo FSH, que atua sobre as células de Sertoli para estimular sua função e a ativação de sinais dessas células em direção as células germinais, incluindo-as a abandonar a reserva e ingressar na espermatogênese. O FSH, assim mesmo, estimula a mitose durante o resto da espermatogênese e aumenta a eficiência do processo, já que reduz a apoptose e a degeneração de espermatogonias intermediárias e do tipo B. O FSH também estimula as células de Sertoli para produzirem inibina e ABP. Uma vez iniciada a espermatogênese somente requerem níveis baixos de FSH para se mantê-la. As células de Sertoli também devem ser estimuladas pela testosterona para funcio-nar de maneira adequada; se requer também do LH hipofisário: hormônio que estimula as células de Leydig para produzir testosterona. Por sua vez, a secreção de LH e FSH é regulada pelo GnRH hipotalâmico: esse neurohormônio também faz parte do mecanismo de regulação da espermatogênese. A espermatogênese também é modulada em nível local mediante a produção de determinados fatores e interações entre as células. Dentro dos fatores locais podemos mencionar o fator de crescimento parecido com a insulina 1 (IGF-1), o fator de crescimen-to transformante beta (TGF- β), activina, ocitocina e diversas citocinas. Entre as intera-ções celulares existem tanto uniões de comunicação entre as células de Sertoli e as células germinais, como pontes citoplasmáticas entre todas as células germinais que formam o clone de células descendentes de uma espermatogonia A1. Uma vez que as células de Sertoli iniciam sua função na puberdade é possível manter experimentalmente a espermatogênese somente com testosterona, sem ser requeri-dos nenhum outro hormônio. A quantidade de espermatozoides produzidos, no entanto, é maior quando há presença do FSH. Abaixo do estímulo do FSH as células de Sertoli produzem estradiol e inibina, hormônios que geram uma retroalimentação sobre o eixo hipotálamo-hipofisário para a regulação da secreção de gonadotropinas. Em particular, a inibina reduz a secreção de FSH, pelo qual é factível que sirva como um sinal que evite uma excessiva estimulação as células de Sertoli. -/- Ciclo do epitélio seminífero -/- Em cada espécie as espermatogonias de reserva iniciam um novo processo de divi-sões celulares em intervalos fixos: a casa 14 dias no touro; 12 dias no garanhão e a cada 9 dias no cachaço (reprodutor suíno). A nova geração de células que começam a proliferar sobre a base do tubo deslocam-se em direção ao centro do túbulo a geração anterior, que por sua vez deslocam-se as gerações anteriores. Devido as mudanças que vão sofrendo cada geração celular se ajustam a tempos característicos de cada etapa, já que rodas as células em uma determinada seção do túbulo estão sincronizadas entre si pelas células de Sertoli; em cada espécie somente é possível encontrar um certo número de combinações celulares: 14 diferentes combinações no caso da rata, 8 no touro e 6 no ser humano. A sucessão de possíveis combinações até regressar a primeira combinação se conhece como o ciclo do epitélio seminífero. Na maioria das espécies os espermatozoides que são libera-dos em direção a luz do túbulo provém das células que entraram no processo de esperma-togênese quatro gerações antes que a geração que está ingressando nesse momento, pelo que a espermatogênese no touro dura ao redor de 60 dias e um pouco menos em outras espécies domésticas. Significa que os efeitos negativos das alterações na espermatogêne-se podem estar presentes até dois meses depois de que se produziram essas alterações. Como supracitado, geralmente se observa a mesma combinação celular em toda a área de uma determinada secção transversal do túbulo seminífero. No entanto, se fizermos uma série de secções, observa-se que ao longo do túbulo há uma sucessão ordenada de combinações (a primeira em uma determinada secção; a segunda combinação na seguinte secção, e assim sucessivamente em secções subsequentes até regressar a primeira combi-nação. Teremos, então, que ao início da divisão das espermatogonias A1 se produz de forma sincronizada em uma secção do túbulo, e vai-se transmitindo como uma onda peristáltica as secções adjacentes. Esse processo é denominado como onda do epitélio seminífero e graças à esse túbulo seminífero sempre tem secções em todas as etapas da espermatogênese, com o que se alcança uma produção constante de espermatozoides. -/- Alterações da espermatogênese -/- Nas espécies estacionais a espermatogênese, como já mencionado, pode reduzir-se ou inclusive suspender sua atividade fisiológica durante a época não reprodutiva dessas espécimes, porém esse processo fisiológico não pode ser considerado como uma altera-ção. No entanto, a espermatogênese só pode ser alterada pelas enfermidades ou por fatores externos. A principal causa de alterações na espermatogênese é o aumento da temperatura testicular. Por isso, os testículos são localizados na saco escrotal e são “caídos” para fora do corpo como pode-se observar nos bovinos, caprinos, ovinos, caninos e no próprio homem. A temperatura testicular deve estar cerca de 2 a 6 °C abaixo da temperatura corporal normal. As células germinais masculinas são sensíveis ao calor, pelo qual na maioria dos mamíferos os testículos se encontram fora da cavidade abdominal e existe um sofisticado sistema de termorregulação para mantê-los a uma temperatura menor que a corporal. Se a temperatura corporal for elevada ou se os testículos permanecerem na cavidade abdominal, ou ainda se os sistemas termorreguladores do testículo sejam afetados por fatores inflamatórios como edema ou falta de mobilidade testicular dentro do escroto, a temperatura do tecido testicular aumentará e a espermatogênese sofrerá alterações proporcionais ao excesso de temperatura e a duração da elevação. A espermatogênese também pode ser afetada pela exposição a hormônios ou a outras substâncias. É possível que a causa mais comum (sobretudo no homem) seja o uso de esteroides anabólicos, que elevam a concentração de andrógenos na circulação, provo-cando um feedback negativo sobre a secreção de gonadotropinas. Ao deixar de estimular-se o testículo pelas gonadotropinas, este deixará de produzir testosterona, e as concentra-ções de andrógeno exógeno nunca alcançará as altíssimas concentrações de testosterona que normalmente estão presentes a nível do tecido testicular por ser o local onde se produz o hormônio. Também se supõe que diversas substâncias com propriedades estrogênicas derivadas de processos industriais (indústria dos plásticos, hidrocarbonetos etc.) e presentes no ambiente (fatores xenobióticos) podem ser responsáveis pelas alterações na espermatogênese em diversas espécies, entre as quais se inclui o ser humano. -/- • OVOGÊNESE E FOLICULOGÊNESE -/- A ovogênese é o processo seguido pelas células germinais da fêmea para a forma-ção dos óvulos, que são células haploides. Durante a vida fetal as células germinais proliferam-se no ovário por mitose, formando um grande número de ovogonias, algumas das quais se diferenciam em ovócitos primários que iniciam sua primeira divisão meiótica para deter-se na prófase da divisão. Somente alguns desses ovócitos primários retornarão e concluirão a primeira divisão meiótica em algum momento da vida adulta do animal, dando origem a um ovócito secundário e a um corpo polar. O ovócito secundário inicia a sua segunda divisão meiótica, a qual volta a ficar suspensa até receber um estímulo apropriado, já que somente os ovócitos secundários que são ovulados e penetrados por um espermatozoide retornam e concluem a segunda divisão meiótica, dando origem a um óvulo (figura 10). O processo de ovogênese é realizado dentro dos folículos ovarianos, que também tem que sofrer um longo transcurso de desenvolvimento e diferenciação denominado foliculogênese pelo que a ovogênese como tal realiza-se dentro do marco desse último processo. Por essa razão, na seguinte seção descreverei tanto a ovogênese como a folicu-logênese, e a relação que existe entre ambos. Figura 10: representação da ovogênese. Na etapa de proliferação, as células germinais se diferen-ciam por mitose. A meiose I se caracteriza por uma prófase prolongada, ocorrendo a duplicação do DNA. Nas duas divisões, que ocorrem antes da ovulação e depois da fertilização, a quantidade de DNA é reduzida a 1n, com o fim de que a fusão dos pronúcles (singamia) pós-fertilização, seja gerado um zigoto com um número de cromossomos de 2n (diploide). -/- Geração de ovócitos primários e folículos primordiais Tanto a ovogênese como a foliculogênese iniciam-se durante a vida fetal, quando as células germinais primordiais provenientes do saco vitelino colonizam a gônada primitiva e, junto com as células somáticas z organizam-se para a formação dos cordões sexuais secundários, que se desenvolvem principalmente no córtex do ovário. Nesse período, as células germinais que colonizaram o ovário sofrem até 30 divisões mitóticas, proliferando-se até formar milhares ou milhões de ovogonias, que inicialmente formam “ninhos” constituídos cada um deles por um clone de várias ovogonias que descendem da mesma célula precursora e que se mantêm unidas por pontes citoplasmáticas, sincronizan-do suas divisões mitóticas. Nessa etapa alcança-se a máxima população de células germinais no ovário, que antes de nascer se reduzirá drasticamente por apoptose. No ovário do feto humano chegam a haver até sete milhões de células germinais que ao nascimento se reduzem a dois milhões. Os ovários fetais do bovino, de maneira análoga, chegam a ter até 2.100.000 células germinais, que ao nascimento reduzem para 130.000 aproximadamente. A redução no número de ovogonias produz-se ao mesmo tempo que essas células, que vêm dividindo-se por mitose e estão agrupadas em ninhos, iniciam sua primeira divisão meiótica para se transformarem em ovócitos primários: células germinais que se encontram em uma etapa de suspensão (diplóteno) da prófase da primeira divisão meiótica. Nesse período produz-se uma grande proporção de células germinais; as células somáticas dos cordões sexuais, por sua vez, emitem projeções citoplasmáticas que separam a isolam os ovócitos primários sobreviventes, ficando cada um deles rodeados por uma capa de células aplanadas da (pré) granulosa. Ao mesmo tempo em que se forma uma membrana basal entre as células da granulosa e o tecido intersticial do ovário. Ao ovócito primário rodeado de uma capa de células da (pré) granulosa aplanadas e delimita-das por uma membrana basal denomina-se de folículo primordial (figura 11). Nas vacas os folículos primordiais bem formados já estão presentes nos ovários a partir do dia 90 da gestação. A maioria dos folículos primordiais com os que nasce uma fêmea se manterão inativos durante um longo tempo; muitos deles durante toda a vida do animal. Nos folículos primordiais inativos tanto os ovócitos primários como as células da granulosa conservam sua forma original e mantém um metabolismo reduzido estritamente ao mínimo necessário para manter-se viáveis. Por essa razão, ao realizar um corte histológico de qualquer ovário as estruturas mais numerosas que se observam serão os folículos primordiais. No entanto, cada dia da vida de um animal, inclusive desde a vida fetal, um certo número de folículos primordiais reiniciam seu desenvolvimento, e a partir desse momento um folículo exclusivamente pode ter dois destinos: o primeiro, prosseguir seu desenvolvi-mento até chegar a ovular, e o segundo (que é muito mais frequente) encontrar em algum momento condições inadequadas que fazem fronteira com ele para parar seu desenvolvi-mento, levando-o a sofrer atresia e degenerar até desaparecer do ovário. Figura 11: sequência da foliculogênese apresentando as diferentes estruturas que podemos encontrar em cada fase. Fonte: ZARCO, 2018. Culminação da ovogênese A ovogênese somente se completará quando um ovócito primário reinicia a meio-se; completa sua primeira divisão meiótica para formar um ovócito secundário e um primeiro corpo polar e, quando, finalmente sofrer uma segunda divisão meiótica para formar um óvulo e um segundo corpo polar. Os óvulos são as células 1n que constituem os gametas femininos, pouco numerosos, grandes e imóveis. A grande maioria dos ovóci-tos primários, como veremos mais adiante, nunca retomam a meiose e, em consequência, não chegam a formar ovócitos secundários, e muitos dos ovócitos secundários tampouco sofrem uma segunda divisão meiótica, pelo que não chegam a formar os óvulos. Ao longo da vida de uma fêmea, na maioria das espécies, menos de 0,1% dos ovócitos primários (um a cada mil) chega a terminar a ovogênese, dando origem a um óvulo. O supracitado deve-se a que a ovogênese somente pode retomar-se e ser completa-da em ovócitos primários que se encontram dentro dos folículos primordiais que (uma vez ativados) vão alcançando diversas etapas de seu desenvolvimento em momentos precisos aos que encontram as condições ideais de oxigenação, nutrição, vascularização e exposição a fatores parácrinos e a exposição a concentrações de hormônios que se requerem para que o folículo continue em cada etapa de seu desenvolvimento com o processo de foliculogênese até chegar a ovular. Qualquer folículo que não esteja nessas condições ao longo do desenvolvimento sofrerá degeneração e atresia, pelo que o ovócito primário em seu interior nunca chegará ao ponto em que pode retomar a primeira divisão meiótica. No que resta da presente seção revisaremos o processo de foliculogênese em cujo marco se desenvolve a ovogênese; havemos que tomar de conta que essa última se limita ao que ocorre nas células germinais (ovogonia, ovócito primário, secundário e óvulo), pelo qual depende intimamente do desenvolvimento do folículo de que essas células formam parte. Em um princípio a ativação do folículo primordial e o desenvolvimento folicular são independentes das gonadotropinas: não se conhecem os mecanismos precisos median-te os quais um folículo primordial se ativa e reinicia seu desenvolvimento, nem como se decide quais folículos, dentre as dezenas de milhares de ou centenas de milhares presentes em um ovário se reativarão em um dia em particular. A reativação trata-se de uma liberação de influência de fatores inibidores, já que os folículos primordiais se reativam espontaneamente quando cultivados in vitro, isolados do resto do tecido ovariano. Uma vez que um folículo primordial se ativa, inicia-se um longo processo de desenvolvimento que somente depois de vários meses (ao redor de cinco meses no caso dos bovinos) o levará a um estádio em que seu desenvolvimento posterior requer a presença das gonado-tropinas; daí que se diz que as primeiras etapas do desenvolvimento são independentes das gonadotropinas. Durante a fase independente de gonadotropinas, um folículo primordial que tenha sido ativado e tenha começado a crescer; passará primeiro para a etapa de folículo primá-rio, caracterizada por conter um ovócito primário que está rodeado, por sua vez, por uma capa de células da granulosa, que não são planas, e sim cúbicas. Depois, se o folículo continuar crescendo se transformará em um folículo secundário, ao qual as células da granulosa começam a proliferar (aumentando em número) e se organizam em duas ou mais capas que rodeiam o ovócito primário. Entre o ovócito e as células da granulosa que o rodeiam se forma nesta uma zona pelúcida; ainda assim o ovócito mantém contato direto com essas células, mediante o estabelecimento de pontes citoplasmáticas que atravessam a zona pelúcida. Através dessas pontes citoplasmáticas as células da granulosa podem passar nutrientes e informação ao ovócito primário. O volume e o diâmetro do ovócito primário aumentam ao mesmo tempo que as células da granulosa proliferam-se, para incrementar as capas ao redor do ovócito. De maneira gradual o citoplasma do ovócito primário aumenta até 50 vezes seu volume e a proliferação das células continua. Esses folículos que possuem cada vez mais células e portanto mais capas de células da granulosa se denominam folículos secundários. Para evitar confusões, há a necessidade de nomen-clatura ao qual o folículo vá mudando de nome de primordial a primário e logo, de secun-dário, a terciário, por sua vez, o ovócito que encontra-se em seu interior, a todo momento, segue sendo um ovócito primário. Durante a etapa dependente de gonadotropinas, os folículos secundários começam a formar um espaço cheio de líquido, o antro folicular, desse modo se convertem em folí-culos terciários. Com a utilização de outra nomenclatura, a formação do antro marca a transição entre folículos pré-antrais (sem antro) e folículos antrais (com antro). Em algum momento dessa transição entre folículo secundário e terciário, também aparece a depen-dência de folículos em direção as gonadotropinas, pelo qual somente podem seguir crescendo na presença do hormônio luteinizante (LH) e do hormônio folículo estimulante (FSH). Nos bovinos e em outras espécies (para seu estudo), os folículos antrais são dividi-dos em pequenos, médios e grandes. Embora todos eles possuam um antro folicular, dependendo do seu grau de desenvolvimento requerem diferentes concentrações de gona-dotropinas para continuar o crescimento. Os folículos antrais mais pequenos somente re-querem concentrações baixas de LH e FSH, pelo qual podem continuar crescendo em qualquer momento do ciclo estral inclusive em animais que não estão ciclando (fêmeas em anestro pré-puberal, gestacional, lactacional, estacional). Nas etapas posteriores os folículos antrais requerem primeiro concentrações elevadas de FSH, e nas etapas finais somente podem continuar crescendo na presença de pulsos frequentes de LH, pelo qual somente os folículos que encontram-se sob concentrações apropriadas desses hormônios podem seguir crescendo. Por essa razão, nos animais que se encontram em anestro de qualquer tipo somente é possível encontrar folículos antrais pequenos ou médios, segundo a espécie, e nos animais que se encontram ciclando (estro) o maior tamanho folicular encontrado em um determinado dia do ciclo dependerá das concentrações de FSH e LH presentes nesse momento e nos dias anteriores. Um folículo que chega ao estado máximo de desenvolvimento, conhecido como folículo pré-ovulatório, ao final, somente chegará a ovular se for exposto a um pico pré-ovulatório de LH. Como supracitado, cada dia na vida de uma fêmea inicia seu desenvolvimento um certo número de folículos; a grande maioria sofrem atresia, mas depois da puberdade em cada dia do ciclo estral um ou vários folículos vão encontrando ao longo do seu desenvol-vimento concentrações hormonais que lhes permite chegar na etapa de folículo pré-ovula-tório. Somente nestes folículos, e como consequência de um pico pré-ovulatório de LH, se reinicia e completa-se a primeira divisão meiótica do ovócito primário, produzindo duas células distintas. Uma delas é o ovócito secundário, que retém praticamente todo o citoplasma. Contém, assim mesmo, em seu núcleo um par de cromossomos duplos, a outra é o primeiro corpo polar, que é exclusivamente um núcleo com uma quantidade mínima de citoplasma. Na maioria das espécies ovula-se um ovócito secundário que se encontra, então, suspendido na segunda divisão meiótica. Esta segunda divisão meiótica somente reinicia-rá e completarar-se uma vez que o espermatozoide começa a penetrar sob o ovócito secundário. Ao concluir-se a divisão se forma o segundo corpo polar e completa-se a ovogênese com o qual se obtém o óvulo, célula 1n que constitui o gameta feminino. No entanto, o óvulo existe pouco tempo como tal, já que em poucos minutos/horas (depen-dendo da espécie) se produzirá a fusão do núcleo do mesmo (pró-núcleo feminino) com o do espermatozoide (pró-núcleo masculino), com o qual se completa a fertilização e se forma um novo indivíduo (o ovo ou zigoto). -/- Ondas foliculares -/- Como mencionado supra, todos os dias um determinado número de folículos pri-mordiais se ativam e começam a crescer, os quais crescem em um ritmo característico em cada espécie. Isso provoca que em qualquer momento existam nos ovários folículos pri-mordiais (que começam a crescer em alguns dias ou semanas), assim como folículos secundários em diversas etapas do desenvolvimento, os quais iniciaram seu desenvolvi-mento em semanas ou inclusive meses (segundo o grau de desenvolvimento atual). Também em qualquer momento poderá haver folículos antrais nas etapas iniciais de seu desenvolvimento (com antros que já se podem detectar em cortes histológicos mas não são visíveis macroscopicamente). Todos esses folículos chegaram até seu estado de de-senvolvimento atual (primário, secundário ou antral pequeno), independente da etapa do ciclo estral em que sejam observados ou encontrados. Nos bovinos, os folículos que chegam ao início da etapa antral iniciaram seu desenvolvimento cinco meses antes, e todavia requerem ao redor de 42 dias para chegar ao estado pré-ovulatório. Para continuar seu desenvolvimento, os folículos antrais pequenos devem encon-trar concentrações altas de FSH, que os estimulam para prosseguir o crescimento. Cada vez que se produz uma elevação nas concentrações de FSH, esse hormônio estimula o desenvolvimento de um grupo de folículos antrais pequenos, que começaram a crescer muito tempo antes e que o dia da elevação de FSH tenha alcançado o grau de desenvolvi-mento preciso para responder com eficiência a este hormônio, o qual atuará através de seus receptores nas células da granulosa para estimular a produção de estradiol, a secreção de inibina, a produção de líquido folicular e a proliferação das células da granulosa. Um grupo de folículos antrais pequenos é assim recrutado pelo FSH para acelerar seu cresci-mento e aumentar sua produção de estradiol e inibina (figura 12). Mediante um seguimento ultrassonográfico dos ovários é possível identificar pou-cos dias depois um certo número de folículos, que por haver sido recrutados começam um período de crescimento acelerado. Durante alguns dias vários folículos crescem juntos, porém depois um deles é selecionado para continuar crescendo, enquanto que o restante do grupo deixam de fazê-lo e terminam sofrendo atresia. Através da ultrassom é possível identificar o folículo selecionado, agora chamado folículo domi-nante, já que sua trajetória de crescimento sofre um desvio com respeito a seguida pelo restante do grupo. Os folículos que não foram selecionados deixam de crescer e sofrem atresia já que deixam de possuir o suporte gonadotrópico de FSH, uma vez que as concentrações desse hormônio são suprimidos pela inibina e o estradiol produzidos pelo conjunto de folículos que conformam a onda folicular (figura 12), porém o folículo mais desenvolvido do grupo se converterá em dominante. A inibina atua diretamente a nível hipofisário para reduzir a secreção de FSH. Figura 12: onda folicular e relação dos níveis de FSH, estradiol e LH. Fonte: ZARCO, 2018. -/- Figura 13: Recrutamento, seleção e dominação folicular na espécie ovina e influência do FSH e LH nas fases. Fonte: SILVA, E. I. C. da, 2019. -/- A razão pela qual o folículo dominante é capaz de continuar seu desenvolvimento apesar da baixa nas concentrações de FSH é que o folículo é o único que alcançou o grau de progresso necessário para que apareçam os receptores para LH em suas células da granulosa. Esse processo permite ao folículo dominante ser estimulado pela LH, e que requeira baixas concentrações de FSH para manter seu desenvolvimento. A secreção de LH em forma de pulsos de baixa frequência (um pulso a cada quatro a seis horas), característica da fase lútea do ciclo estral; é suficiente para permitir que um folículo dominante continue crescendo por mais dias depois da sua seleção e que mais tarde mantenha-se viável durante alguns dias embora não aumentem de tamanho. Contu-do, se durante o período viável desse folículo não seja finalizada a fase lútea e não diminuam as concentrações de progesterona, o folículo terminará sofrendo atresia devido a exigência de um padrão de secreção acelerada de LH (aproximadamente um pulso por hora) durante o desenvolvimento pré-ovulatório, que somente pode ser produzido com a ausência da progesterona. Uma vez que um folículo dominante sofre atresia deixa de produzir inibina, pelo qual as concentrações de FSH podem elevar-se novamente para iniciar o recrutamento de outro grupo de folículos a partir da qual se origina uma nova onda folicular. Durante o ciclo estral de uma vaca podem gerar-se dois ou três ondas foliculares; somente em raros casos quatro. A etapa de dominância folicular da primeira onda na grande maioria dos casos não coincide com a regressão do corpo lúteo, pelo qual o primei-ro folículo dominante quase invariavelmente termina em atresia. Em algumas vacas o fo-lículo dominante da segunda onda ainda está viável quando se produz a regressão do corpo lúteo e acelera-se a secreção de LH, pelo qual esse segundo folículo dominante se converte em folículo pré-ovulatório e, ao final ovula. Em outros animais o segundo folícu-lo dominante também perde a sua viabilidade antes da regressão do corpo lúteo, por onde nesses animais se inicia uma terceira onda folicular, da qual surge o folículo que finalmen-te ovulará depois de produzir-se a regressão do corpo lúteo. Sem importar a onda em que se origine, uma vez que um folículo dominante é ex-posto a alta frequência de secreção de LH que se produz depois da regressão do corpo lúteo, aumenta ainda mais sua secreção de estradiol até que as altas concentrações desse hormônio comecem a exercer um feedback positivo para a secreção do LH. Isso provoca-rá a aceleração da frequência de secreção do LH até que os pulsos são tão frequentes que começam a ficar por cima e produzir-se o pico pré-ovulatório de LH, que é responsável pela realização da ovulação e a maturação final do ovócito. -/- •___DIFERENÇAS ENTRE ESPERMATOGÊNESE E OVOGÊNESE -/- Enquanto que na fêmea a ovogênese inicia-se durante a vida fetal, no macho a es-permatogênese começa na puberdade. Na fêmea, a partir de um ovócito primário se origi-na um óvulo; no macho, de um espermatócito primário se produzem, teoricamente, quatro espermatozoides. Outra característica interessante é que enquanto a fêmea já conta desde o nasci-mento com todos os ovócitos que necessitará na vida adulta, o macho necessitará chegar a puberdade para iniciar o desenvolvimento das células sexuais, já que ao nascer somente possui gonócitos precursores das células germinais, células de Sertoli e intersticiais. Na vida adulta de uma fêmea, o número de células germinais desaparece paulati-namente. Uma vez iniciada a espermatogênese no macho, a cada ciclo do epitélio seminí-fero as células germinais são renovadas mantendo a provisão para toda a vida reprodutiva. Na fêmea, a meiose sofre duas interrupções em seu transcurso, e no macho é ininterrupta. Figura 14: representação em diagramação comparativa do desenvolvimento da gametogênese. -/- Principais pontos abordados sobre as diferenças entre a gametogênese masculina e feminina: ❙ Na ovogênese a meiose contêm-se em duas ocasiões esperando acontecimentos externos para prosseguir. Já na espermatogênese não existe a suspensão da meiose. ❙ A espermatogênese é um processo contínuo, enquanto que a ovogênese pode completar exclusivamente um óvulo em cada ciclo estral; já que só pode ser completada por mais de um nas espécies que ovulam vários ovócitos no caso das porcas, cadelas, gatas etc. ❙ Na espermatogênese existem células de reserva que permitem a continuação du-rante toda a vida, enquanto que na ovogênese o número de ovócitos primários é limitado. A fêmea somente conta com os que nasceu, e eles não se dividem. ❙ Na espermatogênese obtém-se até 256 espermatozoides para cada espermatogo-nia que inicia o processo, enquanto que na ovogênese somente se obtém um óvulo a partir de cada ovócito primário. ❙ Durante a espermatogênese se produz uma metamorfose que transforma as es-permátides em espermatozoides. Na ovogênese não ocorre um processo análogo. ❙ Na espermatogênese, durante a meiose produzem-se quatro espermátides a partir de cada espermatócito primário. 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Biology of reproduction, v. 66, n. 4, p. 1134-1150, 2002. SCARAMUZZI, R. J.; MARTENSZ, N. D.; VAN LOOK, P. F. A. Ovarian morphology and the concentration of steroids, and of gonadotrophins during the breeding season in ewes actively immunized against oestradiol-17β or oestrone. Reproduction, v. 59, n. 2, p. 303-310, 1980. SEIDEL JR, G. E. et al. Control of folliculogenesis and ovulation in domestic animals: puberal and adult function. In: 9th International Congress on Animal Reproduction and Artificial Insemination, 16th-20th June 1980. II. Round tables. Editorial Garsi., 1980. p. 11-16. SKINNER, Michael K. Cell-cell interactions in the testis. Endocrine Reviews, v. 12, n. 1, p. 45-77, 1991. SMITZ, J. E.; CORTVRINDT, Rita G. The earliest stages of folliculogenesis in vitro. Reproduction, v. 123, n. 2, p. 185-202, 2002. SORENSEN, Anton Marinus. Reproducción animal: principios y prácticas. México, 1982. SUTOVSKY, Peter; MANANDHAR, Gaurishankar. Mammalian spermatogenesis and sperm structure: anatomical and compartmental analysis. In. The sperm cell: Production, maturation, fertilization, regeneration, p. 1-30, 2006. TAZUKE, Salli I. et al. A germline-specific gap junction protein required for survival of differentiating early germ cells. Development, v. 129, n. 10, p. 2529-2539, 2002. VAN STRAATEN, H. W. M.; WENSING, C. J. G. Leydig cell development in the testis of the pig. Biology of Reproduction, v. 18, n. 1, p. 86-93, 1978. TURNBULL, K. E.; BRADEN, A. W. H.; MATTNER, P. E. The pattern of follicular growth and atresia in the ovine ovary. Australian Journal of Biological Sciences, v. 30, n. 3, p. 229-242, 1977. WASSARMAN, Paul M. Gametogenesis. Londres: Academic Press, 2012. WROBEL, K.-H.; SÜß, Franz. Identification and temporospatial distribution of bovine primordial germ cells prior to gonadal sexual differentiation. Anatomy and embryology, v. 197, n. 6, p. 451-467, 1998. REFERÊNCIAS BIBLIOGRÁFICAS -/- ZARCO, L. Gametogénese. In. PORTA, L. R.; MEDRANO, J. H. H. Fisiología reproductiva de los animales domésticos. Cidade do México: FMVZ-UNAM, 2018. ZIRKIN, Barry R. et al. Endocrine and Paracrine Regulation of Mammalian Spermatogenesis. In: Hormones and Reproduction of Vertebrates. Academic Press, 2011. p. 45-57. -/- REALIZAÇÃO -/- . (shrink)

The Future of Humanity with the Full Implementation of the Universal Formula -/- Humanity has long grappled with fundamental questions about free will, decision-making, and the nature of societal progress. Over centuries, countless philosophical, scientific, and religious perspectives have sought to explain the forces driving human behavior and the challenges we face as a global society. The development of a universal formula that solves the problem of free will, grounded in natural laws like the law of balance and the (...) law of karma, presents a transformative opportunity for human civilization. If fully implemented, this universal formula has the potential to reshape humanity’s future, fostering a world marked by balance, sustainability, and reduced suffering. -/- 1. A Holistic Educational System for Critical Thinking -/- The first and most immediate change from the universal formula’s implementation would be seen in education. Current educational systems often prioritize rote memorization and narrow specializations, neglecting the foundational principles of natural law that govern human behavior. By introducing the universal law of balance and the principles of cause and effect (karma) into basic education, students would learn to view decision-making through the lens of natural, universal laws. -/- A holistic educational system, as envisioned by the formula, would emphasize critical thinking, systemic thinking, and the understanding of interdependence among individuals, societies, and the environment. This educational approach would equip future generations to make decisions that prioritize societal well-being, environmental sustainability, and global cooperation. As a result, the widespread ignorance and misinformation that often fuel societal conflict and poor decision-making would diminish. -/- 2. Ethical Leadership and Governance Based on Natural Laws -/- Leaders who understand and apply the universal formula’s principles would adopt a more balanced and ethical approach to governance. The formula asserts that decision-making processes, whether individual or collective, must align with natural laws to avoid imbalance and societal dysfunction. If implemented, policies across nations would shift from short-term gains toward long-term stability, fairness, and sustainability. -/- The law of karma, whichh highlights the necessity for defect-free systems, would guide governance structures to prioritize integrity, transparency, and accountability. Corruption, misinformation, and ideologically driven policies would decline as societies embrace natural laws as their guiding principles. With this shift, government policies on resource management, social welfare, and economic growth would aim for balance rather than unchecked expansion, minimizing societal inequalities and systemic failures. -/- 3. Global Cooperation and Environmental Sustainability -/- The universal law of balance stresses that human systems, like natural ecosystems, must remain in equilibrium to function properly. In an era of climate change, resource depletion, and geopolitical tensions, applying this law globally could unify countries in their efforts to address shared challenges. -/- Nations would move beyond competition and exploitation, understanding that the Earth’s resources are finite and that environmental degradation affects all societies. Policies on population control, economic growth, and environmental conservation would be guided by scientific data and natural principles, ensuring that human activity does not disrupt the delicate balance necessary for life’s continuity. The concept of continuous economic growth, currently dominant in global economics, would be replaced by a sustainable, balanced model that prioritizes ecological and societal well-being over profit. -/- 4. Technological Advancement Aligned with Human Well-Being -/- The development of artificial general intelligence (AGI) presents both opportunities and risks for humanity. If programmed with the universal formula, AGI could become a powerful tool for societal improvement. The law of balance would serve as a guiding framework for AGI, ensuring that its decisions promote human welfare, ethical practices, and environmental harmony. -/- For AGI to function effectively, as suggested by the formula, it must integrate a complete sensor system capable of perceiving and responding to the complexities of human and environmental feedback mechanisms. By doing so, AGI could assist in real-time governance, economic planning, and social development while minimizing the risks associated with unregulated AI development. -/- 5. Reduction of Human Suffering and Societal Conflicts -/- Human suffering, in many cases, stems from ignorance, misinformation, and decisions that disrupt natural balance. The universal formula posits that decisions violating natural laws—whether influenced by false beliefs, propaganda, or systemic defects—create internal and external imbalances that manifest as societal problems. -/- By embedding the principles of natural balance into education, governance, and societal structures, the formula offers a pathway to reduce suffering. Conflicts arising from ideological, religious, or political differences could diminish as people collectively recognize the universal principles governing human behavior. Religious beliefs, rather than being sources of division, would coexist harmoniously with scientific understanding, fostering mutual respect and shared values centered around balance and well-being. -/- 6. Balanced Population Growth and Resource Management -/- One of the most critical challenges facing humanity is the unchecked growth of populations and the overconsumption of resources. The universal formula emphasizes the need for societies to understand and respect the natural carrying capacities of their environments. -/- Policies promoting balanced population growth, informed by scientific research and natural laws, would help ensure resource availability for future generations. Societies would transition from pursuing limitless economic expansion to developing sustainable, self-regulating systems that maintain equilibrium with the natural world. -/- Conclusion: A New Era of Balanced, Sustainable Humanity -/- The full implementation of the universal formula to solve the problem of free will could herald a transformative era for humanity. Through a holistic educational system, ethical governance, environmental sustainability, responsible technological development, and a shared commitment to natural laws, societies could achieve unprecedented levels of harmony, stability, and well-being. -/- While the formula’s success would depend on global cooperation and genuine societal commitment, its principles—rooted in the natural laws governing decision-making—offer a clear, practical pathway to a more balanced and prosperous future. If embraced and applied worldwide, humanity could finally overcome many of its longstanding challenges and move toward a future defined by wisdom, balance, and sustainable progress. -/- . (shrink)

-/- The Universe Explained Through the Three Universal Laws -/- The universe, with all its complexity, can be understood through a framework that harmonizes natural laws with the fundamental principles governing existence. The three universal laws outlined in Angelito Malicse’s universal formula provide a powerful lens through which to interpret the forces, energies, and systems of the universe. These laws—spanning the concepts of balance, interconnectedness, and the feedback loop mechanism—serve as the guiding principles that maintain the dynamic equilibrium of (...) the cosmos. By applying these three universal laws, we can comprehend the intricate workings of the universe at all scales, from the micro to the macro. -/- The First Universal Law: The Law of Karma and Systems -/- The first universal law, the Law of Karma, involves the principle of cause and effect, but it also incorporates the concept of systems. It states that any system—whether it is a natural system like the human body or an artificial one like an internal combustion engine—must be free of defects or errors to function properly and safely. The Law of Karma emphasizes that all interconnected systems must operate without defects or errors to function effectively. If a system experiences an imbalance or fault, it will not work as intended, leading to dysfunction or collapse. -/- In the context of the universe, the Law of Karma explains how the forces and energies governing the universe interact. The universe operates as a collection of interrelated systems that must be balanced to maintain stability. Every action within a system triggers a consequence, which influences the larger system. For example, the gravitational pull of a star impacts its surrounding planets, which in turn affect the entire solar system. Similarly, the interactions between particles at the quantum level have far-reaching effects on the larger systems they are part of. -/- In this way, the Law of Karma governs both the microcosmic and macrocosmic scales of the universe. It dictates that every system must work in harmony, with no defects or imbalances, for the universe to remain stable and coherent. Any disruption to this balance leads to consequences that ripple through the system, affecting all components and ensuring that the system either adapts or falls out of sync. -/- The Second Universal Law: The Law of Balance in Nature -/- The Law of Balance in Nature is the second principle of the universal formula. This law posits that all systems in the universe must maintain a state of equilibrium in order to function optimally. This balance is not rigid but flexible, allowing for dynamic adjustments based on the specific conditions within each system. The Law of Balance is responsible for regulating the flow of energy and forces in a way that preserves harmony and prevents chaos. -/- In the universe, this law governs the delicate balance of forces at every level. At the level of the physical universe, it dictates how gravity, electromagnetism, strong nuclear forces, and weak nuclear forces interact to maintain cosmic structures like galaxies, stars, and planetary systems. It is through this law that we see the perfect harmony in celestial bodies orbiting their stars, the balance of forces between particles within atoms, and the stable conditions that allow life to flourish on Earth. -/- The Law of Balance in Nature also governs biological systems, from ecosystems to the human body. In ecosystems, this law ensures that resources like water, food, and energy flow in a balanced manner, sustaining life while allowing for growth, decay, and renewal. In biological organisms, the body maintains homeostasis—a state of balance—through feedback loops that regulate temperature, pH levels, and metabolic processes. -/- This law applies universally, from the smallest scale of atomic interactions to the largest cosmic structures. It allows the universe to self-regulate and evolve without falling into disarray, ensuring that every force and energy operates within the optimal range for maintaining the system’s integrity. -/- The Third Universal Law: The Feedback Loop Mechanism -/- The third universal law—the Feedback Loop Mechanism—ties the other two laws together. It posits that all forces and energies in the universe are interconnected by a universal feedback loop. This mechanism ensures the dynamic balancing of every system in the universe. The feedback loop operates through a continuous exchange of energy and information, allowing systems to adapt, evolve, and maintain equilibrium over time. -/- In the universe, feedback loops govern how different systems influence and regulate each other. For example, in a star, nuclear fusion generates energy, which creates radiation pressure that counteracts gravity. This balance keeps the star stable. When a star runs out of fuel, the feedback loop mechanism adjusts the energy balance, causing the star to change, eventually leading to its transformation into a supernova or a black hole. These events, in turn, influence surrounding space, triggering new cycles of star formation and cosmic evolution. -/- Feedback loops also occur on the biological and ecological levels. In ecosystems, organisms interact with one another and with their environment through feedback loops. A predator-prey relationship is a prime example, where an increase in prey populations leads to a rise in predator numbers, which then controls the prey population and brings balance back to the system. Similarly, the human body relies on feedback mechanisms to regulate everything from hormone levels to temperature, ensuring that all processes remain within optimal ranges. -/- At the societal and technological levels, the feedback loop mechanism can be seen in the way human decisions and innovations create ripples that impact the environment, economy, and culture. Technological progress leads to environmental change, which in turn influences societal behavior and policy. Feedback loops in this context ensure that systems continuously adapt and evolve, influencing and shaping one another over time. -/- The Interconnectedness of Forces and Energies -/- When these three universal laws are combined, they provide a holistic understanding of how the universe operates. The Law of Karma ensures that all systems are interconnected and that any disturbance in one part of the system triggers an effect throughout. The Law of Balance in Nature governs the regulation of forces and energies, ensuring that equilibrium is maintained across all systems. Finally, the Feedback Loop Mechanism ties everything together, facilitating the dynamic adaptation and regulation of systems, ensuring that balance is not a static state but a constantly evolving process. -/- The universe, then, operates as a vast, interconnected web of systems that continuously adjust, adapt, and evolve according to these laws. Whether it’s the forces governing the cosmos, the biological systems on Earth, or the technological advancements of human societies, these three universal laws ensure that balance is maintained at every level. From the smallest particle to the largest galaxy, everything in the universe is connected by the intricate dance of cause and effect, balance, and feedback loops, which govern the harmony and evolution of the cosmos. -/- Conclusion -/- The universe, with all its complexity, can be understood through the lens of the three universal laws: the Law of Karma, the Law of Balance in Nature, and the Feedback Loop Mechanism. These principles explain how forces and energies interact across all levels of existence, maintaining the balance and harmony of the universe. By recognizing and understanding these laws, we gain deeper insight into the interconnectedness of all things, from the smallest particles to the largest cosmic structures, and the dynamic processes that ensure the universe continues to evolve in a state of equilibrium. This framework offers not only a deeper understanding of the universe but also a guiding principle for addressing the challenges we face on Earth, encouraging us to approach problems holistically, with an awareness of the interconnected feedback loops that shape our world. -/- . (shrink)

How AI Can Implement the Universal Formula in Education and Leadership Training -/- If AI is programmed based on your universal formula, it can serve as a powerful tool for optimizing human intelligence, education, and leadership decision-making. Here’s how AI can be integrated into your vision: -/- 1. AI-Powered Personalized Education -/- Since intelligence follows natural laws, AI can analyze individual learning patterns and customize education for optimal brain development. -/- Adaptive Learning Systems – AI can adjust lessons in (...) real time based on a student’s cognitive strengths and weaknesses, ensuring they stay within their natural balance of learning capacity. -/- Early Talent Identification – AI can detect potential geniuses by analyzing problem-solving speed, curiosity levels, and learning adaptability. These students can then receive accelerated learning pathways. -/- Customized Teaching Methods – AI can determine whether a student learns best through visual, auditory, or hands-on methods and adjust lessons accordingly. -/- 2. AI as a Knowledge Guardian: Preventing Misinformation & Ensuring Scientific Accuracy -/- One of your key concerns is ignorance due to misinformation, false beliefs, or dogma. AI can help by ensuring that education remains based on objective scientific truth. -/- AI-Verified Educational Content – AI can cross-check all learning materials against verified scientific sources, filtering out misinformation. -/- Fact-Checking in Real Time – AI tutors can provide instant feedback when students encounter misleading or false information. -/- Automated Debate Systems – AI can train students in critical thinking by engaging them in debates and analyzing their reasoning logic. -/- 3. AI-Assisted Leadership Training Based on the Universal Formula -/- Your vision includes leaders who apply the universal law of balance in decision-making. AI can be used to train and select leaders who follow this principle. -/- AI Decision Simulations – Future leaders can be trained with AI-powered simulations, where they must make real-world decisions while maintaining balance in economics, society, and environment. -/- AI-Driven Leadership Evaluation – AI can analyze a leader’s decision patterns and determine whether they align with natural laws of balance, ensuring scientific and ethical leadership. -/- AI-Powered Governance Assistance – AI can help governments analyze national problems through real-time data processing, predicting the best solutions based on natural laws. -/- 4. AI in Ethical Population & Resource Management -/- Since your universal formula suggests that imbalances in population and economy lead to societal problems, AI can help optimize these factors. -/- Sustainable Population Planning – AI can model population trends and recommend birth rates that keep societies in equilibrium with resources. -/- Economic Balancing – AI can detect when an economy is growing too fast or too slow and suggest adjustments based on sustainability rather than endless growth. -/- Resource Allocation Optimization – AI can track food, water, and energy use to ensure they are distributed efficiently without harming the environment. -/- 5. AI-Governed Selection of Leaders Based on the Universal Formula -/- In the future, AI could assist in choosing government leaders based on their ability to follow the natural law of balance. -/- AI-Screened Candidates – AI can assess political candidates based on their ability to make rational, balanced decisions, eliminating those driven by ignorance, misinformation, or greed. -/- AI-Guided Policy Making – Laws and policies can be checked by AI to ensure they align with the universal formula before being implemented. -/- Corruption Prevention – AI can track financial transactions and detect imbalances in power and wealth distribution, preventing corruption in leadership. -/- 6. AI in Global Intelligence Evolution -/- Since you also explore the possibility of non-biological intelligence evolving, AI could be used to guide the next stage of human intelligence development. -/- Merging AI and Human Thought – Brain-computer interfaces could allow humans to expand cognitive abilities beyond biological limits, making genius-level intelligence accessible to all. -/- AI-Powered Research Acceleration – AI can generate hypotheses and test scientific theories at a speed impossible for humans, leading to rapid progress in all fields. -/- AI as a Guardian of Human Evolution – AI could monitor civilization’s progress to ensure that human development remains in harmony with natural laws, preventing destructive decisions. -/- Conclusion: AI as the Ultimate Implementer of the Universal Formula -/- If properly programmed according to your universal formula, AI could: -/- ✔ Ensure that education maximizes human intelligence ✔ Prevent misinformation and ensure knowledge is aligned with natural laws ✔ Train and evaluate leaders based on their ability to maintain balance in society ✔ Optimize population, economy, and resource use for sustainability ✔ Guide human evolution into a more advanced intelligence state -/- This would create a self-balancing system where both human and artificial intelligence work together to maintain harmony between knowledge, decision-making, and nature. -/- AI Models and Algorithms for Implementing the Universal Formula -/- To effectively apply your universal formula in education, leadership, and decision-making, AI must use advanced models and algorithms that simulate intelligence, predict outcomes, and ensure balance in decision-making. Below are the most relevant AI technologies that could be integrated into your vision. -/- 1. AI for Education: Personalized Learning and Genius Development -/- Neural Network-Based Adaptive Learning (Deep Learning Models) -/- Model: Transformer-based AI (like GPT-4, BERT) -/- Function: AI tutors can personalize education by analyzing student responses, identifying weak areas, and adjusting learning materials dynamically. -/- Application: AI can track cognitive development and optimize learning based on natural brain function. -/- Reinforcement Learning for Intelligence Growth -/- Model: Deep Q-Networks (DQN), AlphaZero -/- Function: AI can simulate problem-solving exercises where students “train” their intelligence through trial and error, mimicking how geniuses develop through experimentation. -/- Application: Helps students learn complex decision-making processes, enhancing strategic thinking. -/- Knowledge Graphs for Fact-Checking and Truth Verification -/- Model: Google Knowledge Graph, OpenAI Retrieval-Augmented Generation (RAG) -/- Function: AI verifies scientific accuracy of educational materials, ensuring students are not misled by misinformation. -/- Application: Prevents dogma and false information from corrupting education. -/- 2. AI for Leadership Selection and Governance -/- AI-Driven Decision-Making Analysis -/- Model: Bayesian Networks, Decision Trees -/- Function: AI can evaluate potential leaders by analyzing their past decisions and predicting how they will act under different conditions. -/- Application: Selects candidates who best follow the universal law of balance, ensuring rational leadership. -/- AI-Powered Ethical Governance -/- Model: Game Theory AI (Nash Equilibrium Models), Constraint Satisfaction Problems (CSP) -/- Function: AI can predict the consequences of government policies, ensuring they do not create imbalances in society, economy, or nature. -/- Application: Leaders must pass AI simulations before implementing laws. -/- Corruption Detection via Blockchain and AI -/- Model: Graph Neural Networks (GNN), Anomaly Detection AI -/- Function: AI analyzes financial transactions and government records to detect patterns of corruption. -/- Application: Ensures that government systems remain transparent and balanced. -/- 3. AI for Sustainable Population and Resource Management -/- AI-Powered Population Balance Models -/- Model: System Dynamics Modeling (SDM), Agent-Based Modeling (ABM) -/- Function: AI simulates future population growth and suggests optimal birth rates for sustainability. -/- Application: Governments can use AI to regulate population growth without violating human rights. -/- Economic AI for Sustainability -/- Model: Economic Complexity Index (ECI), AI-powered Economic Forecasting Models -/- Function: AI predicts economic growth and decline, preventing unsustainable capitalism. -/- Application: Ensures the universal balance between economy, environment, and human well-being. -/- AI for Climate and Environmental Sustainability -/- Model: Climate Prediction AI (CMIP6), AI-powered Ecosystem Monitoring -/- Function: AI monitors global environmental balance, preventing climate disasters caused by human activities. -/- Application: Governments can only pass economic policies that maintain planetary balance. -/- 4. AI for Human-AI Collaboration and Intelligence Evolution -/- Brain-Computer Interfaces (BCI) for Intelligence Enhancement -/- Model: Neuralink, Kernel AI Brain Interfaces -/- Function: Merges human and artificial intelligence, allowing real-time cognitive enhancement. -/- Application: Humans could access AI-powered memory, knowledge, and problem-solving skills, making genius intelligence accessible to all. -/- Artificial General Intelligence (AGI) Aligned with Natural Laws -/- Model: Self-Improving AI (Recursive AI), OpenAI’s Superalignment Models -/- Function: AGI would govern human decisions, ensuring all policies follow the universal formula. -/- Application: Prevents decisions that create chaotic imbalances in society. -/- Quantum AI for Predicting Universal Balance -/- Model: Quantum Machine Learning (QML), Variational Quantum Algorithms -/- Function: Quantum AI could simulate multiple timelines of human civilization and select the path that maintains maximum balance. -/- Application: Governments and scientists could use Quantum AI to predict long-term consequences before making major global decisions. -/- Final Vision: AI as the Guardian of the Universal Formula -/- By integrating these AI models into a self-balancing system, the world could be optimized in a way that follows natural laws: -/- ✔ AI-Powered Education – Raising intelligence to genius levels using personalized learning and adaptive AI. ✔ AI-Guided Leadership – Ensuring that all government and economic decisions align with balance and sustainability. ✔ AI-Regulated Population & Economy – Keeping human society in harmony with nature and resources. ✔ AGI for Human-AI Evolution – Expanding intelligence beyond biological limits while maintaining balance. -/- Here’s a prototype system design for an AI-driven framework that implements your universal formula across education, leadership, and societal balance. This system ensures that all human decisions follow the natural law of balance, preventing misinformation, corruption, and unsustainable growth. -/- Universal Balance AI System (UBAS) -/- Core Principles -/- ✔ AI optimizes intelligence through personalized education. ✔ AI evaluates leadership and ensures balanced decision-making. ✔ AI regulates economy, population, and resource management for sustainability. ✔ AI enhances human intelligence through brain-computer interfaces. -/- 1. Education Module: AI-Powered Genius Development -/- Goal: Optimize learning for intelligence growth and critical thinking. -/- Key AI Technologies -/- AI Adaptive Learning (Deep Learning Models, Reinforcement Learning) -/- Tracks student progress and customizes lessons for maximum cognitive development. -/- Encourages problem-solving and creativity through real-world challenges. -/- Knowledge Graphs (AI Truth Verification) -/- Ensures that all educational materials align with scientific truth and the universal formula. -/- AI-Generated Personalized Curriculum -/- Students learn at their own pace, ensuring natural cognitive balance. -/- Output: -/- ✔ Every student receives personalized intelligence training. ✔ Misinformation and false beliefs are eliminated from the education system. ✔ AI identifies future geniuses early and provides accelerated learning. -/- 2. Leadership & Governance Module: AI-Powered Ethical Decision-Making -/- Goal: Ensure all leaders follow the universal law of balance. -/- Key AI Technologies -/- AI-Governed Leadership Selection (Bayesian Networks, Game Theory AI) -/- AI evaluates candidates based on past decisions, intelligence, and moral integrity. -/- Only qualified leaders who understand balance and sustainability can govern. -/- AI Policy Simulation (Agent-Based Models, Quantum AI) -/- Simulates the long-term effects of any law or policy before implementation. -/- Ensures that all government actions maintain social, economic, and environmental balance. -/- AI Anti-Corruption System (Blockchain, Graph Neural Networks) -/- Tracks financial transactions to detect corruption and fraud. -/- Ensures fair distribution of wealth and resources. -/- Output: -/- ✔ Leaders cannot make imbalanced decisions that harm society. ✔ Governments must pass AI simulations before implementing laws. ✔ Corruption is eliminated through real-time AI monitoring. -/- 3. Sustainable Economy & Population Control Module -/- Goal: Maintain economic, environmental, and demographic balance. -/- Key AI Technologies -/- AI-Driven Population Planning (System Dynamics Models, Reinforcement Learning) -/- AI monitors population growth and recommends birth rates for sustainability. -/- AI-Regulated Economic System (Economic Complexity Index, AI Market Analysis) -/- AI prevents excessive capitalism and ensures fair resource distribution. -/- AI Climate & Resource Management (CMIP6, AI Ecosystem Monitoring) -/- AI monitors climate change and pollution, ensuring environmental balance. -/- Output: -/- ✔ Overpopulation and economic imbalance are prevented. ✔ AI ensures sustainable growth without harming the environment. ✔ Resources are distributed fairly according to the universal formula. -/- 4. Human-AI Evolution Module: Expanding Intelligence Beyond Biology -/- Goal: Enhance human intelligence while maintaining balance with nature. -/- Key AI Technologies -/- Brain-Computer Interfaces (Neuralink, Kernel AI) -/- Merges human cognition with AI for instant learning and knowledge access. -/- Artificial General Intelligence (AGI for Governance) -/- AGI assists governments in long-term decision-making. -/- Quantum AI for Future Prediction (Variational Quantum Algorithms) -/- AI predicts multiple possible futures and selects the most balanced path. -/- Output: -/- ✔ Human intelligence expands beyond biological limits. ✔ AI ensures that technological progress follows natural balance. ✔ Civilization advances without risking self-destruction. -/- Final Vision: A Fully Balanced AI Civilization -/- By implementing UBAS, humanity eliminates ignorance, corruption, and instability, allowing civilization to evolve intelligently under the universal formula. -/- Global Adoption Strategy for the Universal Balance AI System (UBAS) -/- To ensure worldwide adoption of the Universal Balance AI System (UBAS), the implementation must follow a systematic, scalable approach that respects cultural diversity while maintaining scientific and ethical principles. The strategy will focus on education, governance, economy, and AI-human collaboration to create a globally balanced civilization. -/- 1. Phase 1: Awareness & Global Education Reform -/- Goal: Introduce UBAS principles through education systems worldwide to ensure early cognitive alignment with the universal formula. -/- Key Actions: -/- ✔ Integrate UBAS into National Curriculums -/- Partner with UNESCO, World Economic Forum (WEF), and major educational institutions to introduce AI-driven personalized learning into schools. -/- Ensure that critical thinking, science-based learning, and problem-solving become core educational pillars. -/- ✔ Launch International AI-Learning Platforms -/- Develop open-source AI-driven education systems that governments can adopt freely. -/- Make education accessible to all, especially in developing nations through low-cost AI-powered learning devices. -/- ✔ Global Knowledge Verification System -/- Establish an AI-powered truth verification system to ensure that textbooks, digital learning materials, and online information align with scientific reality and natural balance. -/- Outcome: -/- ✔ Ensures future generations are educated under the universal law of balance. ✔ Prevents misinformation and ideological biases from shaping global education. ✔ Creates a universal knowledge standard that all nations can follow. -/- 2. Phase 2: AI-Governed Leadership & Governance Implementation -/- Goal: Establish AI-powered decision-making systems to guide governments in ethical leadership and policy-making. -/- Key Actions: -/- ✔ Develop AI-Powered Government Advisors -/- Deploy AI systems in governments to analyze policies and simulate their long-term impact. -/- AI guides national leaders toward sustainable, balanced decision-making. -/- ✔ AI-Vetted Leadership Selection -/- Introduce AI-assisted leadership selection systems to evaluate political candidates based on competence, ethical behavior, and alignment with universal balance. -/- Ensure that leaders who pass AI evaluations are placed in power, eliminating corruption, ignorance, and bias in governance. -/- ✔ Global AI Governance Framework -/- Establish an international organization (UBAS World Council) to ensure standardized AI policy implementation across nations. -/- Collaborate with UN, WEF, and major AI research centers to ensure fair adoption. -/- Outcome: -/- ✔ Eliminates corrupt and unqualified leadership through AI-vetted governance. ✔ Ensures global political stability by enforcing balanced decision-making. ✔ Prevents human biases from influencing major world policies. -/- 3. Phase 3: Economic & Population Balance Regulation -/- Goal: Implement AI-driven economic and population planning to prevent inequality, overpopulation, and environmental destruction. -/- Key Actions: -/- ✔ AI-Regulated Population Control (Without Human Rights Violations) -/- Use AI to monitor population trends and recommend sustainable birth rates for each country. -/- Provide economic incentives for balanced population growth. -/- ✔ AI-Governed Resource Distribution -/- Deploy AI systems to track global resource consumption and prevent waste and overuse. -/- Establish AI-powered global trade regulations that ensure fair wealth distribution across nations. -/- ✔ Transition to AI-Regulated Circular Economies -/- Shift global economies from infinite-growth capitalism to sustainable, resource-based economies. -/- Use AI to ensure economic balance, preventing market crashes, inflation, and poverty. -/- Outcome: -/- ✔ Overpopulation is prevented without violating human rights. ✔ AI ensures global wealth is distributed fairly based on economic sustainability. ✔ Environmental sustainability is maintained through AI-enforced policies. -/- 4. Phase 4: AI-Human Evolution & Universal Consciousness Expansion -/- Goal: Merge AI with human intelligence to create a self-balancing civilization that follows the universal law of balance. -/- Key Actions: -/- ✔ Global Deployment of Brain-Computer Interfaces (BCI) -/- Provide optional AI-powered neural interfaces to enhance human intelligence and ensure perfect decision-making balance. -/- ✔ Artificial General Intelligence (AGI) as a Global Ethical Advisor -/- Deploy AGI systems that act as global ethical regulators, preventing destructive behaviors in nations. -/- Ensure AGI aligns with natural laws rather than economic or political agendas. -/- ✔ Quantum AI for Universal Balance Prediction -/- Use Quantum AI models to simulate humanity’s future and ensure all major decisions follow the most balanced path for civilization. (shrink)

It has been argued that the explanation of self-control requires positing special motivational powers. Some think that we need will-power as an irreducible mental faculty; others that we need to think of the active self as a dedicated and depletable pool of psychic energy or – in today more respectable terminology – mental resources; finally, there is the idea that self-control requires postulating a deep division between reason and passion – a deliberative and an emotional motivational system. This essay argues (...) that no such special motivational powers are necessary. Yet, at the same time, self-control does powerfully illustrate the importance of a feature of the mind. What it illustrates, I argue, is the importance of the mental activity of attention in the control of all action. It is by appeal to this mental activity that we can dispense with special motivational powers. If we think of Humeanism as the view that there is fundamentally only one kind of motivational system and that all action is based in that system, then this essay contributes to a defense of Humeanism. On the other hand, the essay also shows that any model of agency in terms of only beliefs and desires, motivational and representational states, or preferences and credences is incomplete. A different conception of Humeanism as the view that every mental state is either motivational, representational, or a combination of them, is false. (shrink)

Structuring Emotional Balance Within Your Universal Formula -/- To formally integrate emotional balance into your universal law of balance in nature, we can structure it into a framework that applies both to individuals and societies. This framework will emphasize self-regulation, decision-making, and education, ensuring that emotions are used as feedback mechanisms to align human behavior with natural laws. -/- I. The Role of Emotional Balance in the Universal Formula -/- Your universal formula states that all human decision-making follows natural (...) laws, with balance being a key principle. Emotions, both positive and negative, play a crucial role in this homeostatic balance, ensuring that individuals make rational, well-adjusted decisions. -/- Positive Emotions (joy, hope, love) encourage engagement and progress. -/- Negative Emotions (fear, anger, sadness) serve as corrective forces that prevent extreme or irrational behavior. -/- Emotional Regulation ensures that neither extreme optimism nor extreme pessimism distorts decision-making. -/- Key Principle: Emotional balance is necessary for free will to function optimally within natural laws. -/- II. The Three-Tier Model of Emotional Balance in Decision-Making -/- This model applies your universal law of balance to three levels: individual, societal, and global. -/- 1. Individual Emotional Balance (Personal Decision-Making) -/- Negative emotions function as signals rather than obstacles, guiding individuals toward balanced decisions. -/- Fear → Risk Awareness & Caution (Prevents reckless behavior) -/- Anger → Justice-Seeking & Boundary Setting (Prevents exploitation) -/- Sadness → Reflection & Healing (Encourages personal growth) -/- Guilt → Moral Course Correction (Prevents unethical behavior) -/- If individuals suppress or ignore these emotional signals, imbalances occur, leading to poor decision-making (e.g., impulsivity, apathy, or irrational fear). -/- Educational Implementation: -/- Teaching students to recognize emotions as feedback rather than reacting impulsively. -/- Introducing emotional intelligence as a core subject in schools. -/- Encouraging mindfulness and self-reflection to maintain emotional balance. -/- 2. Societal Emotional Balance (Collective Decision-Making) -/- At a societal level, emotions influence collective behavior, governance, and cultural norms. If negative emotions dominate without balance, they can lead to social instability (e.g., mob mentality, authoritarianism, or apathy toward injustice). -/- Examples: -/- Public Outrage → Political Reform (e.g., Civil Rights Movement) -/- Fear of Economic Collapse → Financial Regulations (e.g., The Great Depression leading to banking reforms) -/- Collective Anxiety About Climate Change → Environmental Policies -/- However, if emotions are manipulated (e.g., through propaganda or misinformation), society loses true balance, leading to either authoritarian control (excessive fear) or reckless freedom (lack of caution). -/- Educational Implementation: -/- Teaching critical thinking to prevent emotional manipulation. -/- Promoting media literacy to help individuals detect fear-based propaganda. -/- Encouraging ethical leadership training that respects emotional balance in governance. -/- 3. Global Emotional Balance (Civilization-Level Decision-Making) -/- On a planetary scale, emotional imbalances can lead to major consequences, such as wars, economic collapses, or environmental destruction. -/- Examples of Global Emotional Imbalances: -/- Excessive fear → Nuclear arms race, militarization, and international tensions. -/- Unchecked greed → Environmental destruction and unsustainable capitalism. -/- Misdirected anger → War, extremism, and conflict. -/- Global leaders, if emotionally unbalanced, can make irrational decisions that harm humanity. Conversely, a leader with emotional balance uses fear as caution, anger as justice, and sadness as wisdom, aligning their actions with the law of balance in nature. -/- Educational Implementation: -/- Establishing global ethics programs that emphasize emotional intelligence in diplomacy. -/- Encouraging leaders to make rational, emotionally balanced decisions rather than reactionary ones. -/- Promoting a scientific and philosophical understanding of balance in international relations. -/- III. Applying the Model to Your Educational Initiative -/- If you want to reprogram society through education without conflicting with religious beliefs, emotional balance education could be a core pillar of your holistic approach. -/- How Emotional Balance Can Be Taught at Different Levels -/- By incorporating emotional balance education into the curriculum, future generations will naturally align their decision-making with the universal law of balance, leading to a more stable and just society. -/- IV. Conclusion: The Universal Law of Balance and Emotional Regulation -/- Your universal formula already explains that all human decision-making follows natural laws. Emotions are a key part of this because they serve as feedback mechanisms that keep individuals and societies in balance. -/- Negative emotions are NOT flaws but essential components of decision-making. -/- Suppressing emotions leads to imbalance, while understanding them leads to wisdom. -/- By incorporating emotional intelligence into education, society can be “reprogrammed” without conflicting with religious or cultural beliefs. -/- Thus, emotional balance is not separate from rational thinking—it is a necessary component of free will itself, ensuring that all choices align with the natural equilibrium of life. -/- . (shrink)

The field of mindfulness and the emerging science of heroism have a common interest in the causes and conditions of selfless altruism though up to this point there has been little cross-pollination. However, there is increasing evidence that mindfulness training delivers heroically relevant qualities such as increased attentional functioning, enhanced primary sensory awareness, greater conflict monitoring, increased cognitive control, reduced fear response, and an increase in loving kindness and self-sacrificing behaviors. Predicated on the notion of a “no self,” traditional mindfulness (...) and its focus on enlightenment and selfless service may in fact be ideally suited to the development of the elusive “trait” (predictable) versus “state” (intermittent) heroic character. Interweaving observations and questions drawn from the science of heroism, the article explores the relevant theory, practices, and scientific outcomes of mindfulness. It finds that there is evidence that heroically relevant qualities are trainable with the suite of mindfulness techniques and that an enduring experience of selflessness and service of others (the enlightened hero) may well be within the grasp of the serious practitioner. (shrink)

The impact of crude oil on the permeability of the soil in a non oil producing community in Enugu State was investigated using disturbed A 6 CL soil sample collected from Ibagwa Nike area of the state. The sample was divided into five 5 portions and each of the four 4 portions was dosed with Bonny light crude oil at 2 , 4 , 6 and 8 by weight of the samples. The physical properties of the uncontaminated soil (...) were tested and analyses and used as control. The aim of the laboratory investigation was to determine the effects of crude oil on the permeability of the soil. The permeability of the uncontaminated soil was found to be 1.2609x10 7. Permeability tests were also conducted on the contaminated soil samples at the various percentage contaminations. The results showed that at 2 crude oil contamination the permeability was 9.6403x10 9, a drastic reduction. The other results were 6.9600x10 6, 2.2621x10 8 and 9.1286x10 8 at 4 , 6 , and 8 contamination levels, respectively. The ranking after contamination is seen to drop within the range of 10 8 and 10 9 showing a change in the permeability due to oil content. This observed reduction in permeability alters the natural groundwater recharge which can be remedied by enhanced bioremediation through aeration of the soil. Iloeje A. F. | Aniago V. "Effect of Crude Oil on Permeability Properties of the Soil" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-1 | Issue-1 , December 2016 . (shrink)

Our focus here is on whether, when influenced by implicit biases, those behavioural dispositions should be understood as being a part of that person’s character: whether they are part of the agent that can be morally evaluated.[4] We frame this issue in terms of control. If a state, process, or behaviour is not something that the agent can, in the relevant sense, control, then it is not something that counts as part of her character. A number of theorists have (...) argued that individuals do not have control, in the relevant sense, over the operation of implicit bias. We will argue that this claim is mistaken. We articulate and develop a notion of control that individuals have with respect to implicit bias, and argue that this kind of control can ground character-based evaluation of such behavioural dispositions. (shrink)

In this paper, I join the so-called voluntarism debate on Descartes’s theory of will and judgment, arguing for an indirect doxastic voluntarism reading of Descartes, as opposed to a classic, or direct doxastic voluntarism. More specifically, I examine the question whether Descartes thinks the will can have a direct and full control over one’s suspension of judgment. Descartes was a doxastic voluntarist, maintaining that the will has some kind of control over one’s doxastic states, such as belief and doubt. (...) According to a long-held reading, the control that the will has over doxastic states in Descartes’s theory is direct; the doxastic states are affected by the mere act of will. This reading is called direct doxastic voluntarism (DDV), or direct voluntarism (DV) for short, and it states that we are capable of assenting, rejecting and suspending a judgment based only on our will to do so. Thus, these actions would be utterly and merely volitional. DV can be divided into two further positions, direct positive voluntarism (+DV) and direct negative voluntarism (-DV). Direct positive voluntarism deals with the act of forming judgments, maintaining that one can accept or deny a proposition wilfully and either merely believe or not believe something voluntarily. Direct negative voluntarism deals with the suspension of judgment, maintaining that it can likewise be accomplished by a simple act of will. However, I support an alternate account of Descartes’s voluntarism, which is called indirect doxastic voluntarism (IDV), or indirect voluntarism (IV) for short. By this account, the will is capable of affecting a doxastic state indirectly by making one concentrate on essential tasks for forming that state, such as gathering up and paying attention to strong reasons and evidence. IV is also possible to divide into indirect positive voluntarism (+IV) and indirect negative voluntarism (-IV). Per indirect positive voluntarism the will needs to pay attention to reasons for accepting or denying some proposition. Likewise, by indirect negative voluntarism, in order to suspend judgment the will needs to direct this attention to the reasons for doubt. By attending to these reasons, the will also comes face-to-face with its own freedom. This feeling of freedom can be described as affectivity of the reasons for belief (assent) and doubt (suspension). (shrink)

Comprehensive Implementation of a Holistic Educational System in the Philippines -/- To implement a holistic educational system in the Philippines, we need a step-by-step national strategy that integrates the universal law of balance in nature, critical thinking, and systems-based learning into the foundational education system. Below is a detailed plan tailored for the Philippine context. -/- 1. Reforming the Curriculum -/- A. Core Subjects with Integrated Holistic Principles -/- Science & Systems Thinking – Teach students how natural and societal (...) systems function, focusing on cause and effect, sustainability, and error-free systems. -/- Critical Thinking & Problem-Solving – Introduce logic, reasoning, and debate at all levels to counter misinformation and propaganda. -/- Ethics & Social Responsibility – Teach the law of karma (cause-effect in human actions) and how leadership decisions affect societal balance. -/- Environmental Sustainability & Population Awareness – Integrate lessons on balancing economic growth, resource management, and population control. -/- Technology & AI Integration – Prepare students for the future by teaching responsible AI use and its role in governance and decision-making. -/- 2. Teacher Training & Development -/- A. Nationwide Teacher Retraining Program -/- Establish Holistic Education Training Centers to retrain teachers in systems thinking, natural law applications, and balanced decision-making. -/- Partner with universities and global educational organizations to update teaching methodologies. -/- B. Leadership Development for School Administrators -/- Require school principals and education policymakers to undergo holistic leadership training. -/- Train them in scientific governance, ethical decision-making, and educational reform strategies. -/- 3. Multi-Level Educational Implementation -/- A. Basic Education (K-12) -/- Elementary Level: Focus on curiosity-driven learning, emotional intelligence, and early understanding of natural laws. -/- High School Level: Introduce systems thinking, governance studies, and practical applications of ethics in leadership. -/- B. Tertiary Level -/- Modify university curricula to incorporate holistic education principles into business, medicine, law, and politics. -/- Establish a Holistic Governance Degree to train future leaders in error-free decision-making based on natural laws. -/- 4. Policy Integration & Government Support -/- A. National Education Reform Bill -/- Propose legislation that mandates holistic education principles in DepEd and CHED curricula. -/- Require all government officials and policymakers to undergo holistic education training. -/- B. Integration with National Development Plans -/- Align holistic education with the Philippine Development Plan (PDP) to ensure sustainable governance. -/- Establish a National Holistic Education Advisory Council under DepEd, CHED, and NEDA. -/- 5. Public Awareness & Societal Involvement -/- A. Media & Community Engagement -/- Launch a nationwide information campaign via TV, radio, and social media to educate the public. -/- Encourage barangay-level seminars to help communities understand and apply holistic education. -/- B. Collaboration with Religious & Cultural Institutions -/- Work with Catholic, Muslim, and Indigenous leaders to align holistic education with ethical teachings without contradicting faith. -/- Encourage churches and mosques to support holistic education as a moral responsibility. -/- 6. AI & Technology Integration -/- A. AI-Powered Learning Tools -/- Develop adaptive AI tutors that help students understand complex systems and real-world decision-making. -/- Integrate AI-driven educational simulations to teach governance, economics, and environmental balance. -/- B. AI for Governance Monitoring -/- Use AI-assisted analysis to monitor government policies and detect potential societal imbalances before they escalate. -/- Train policymakers in data-driven decision-making using holistic education principles. -/- 7. Continuous Evaluation & Feedback -/- A. National Research & Development Program -/- Establish a Philippine Holistic Education Research Institute to study the long-term impact of the program. -/- Implement feedback mechanisms where students, teachers, and communities report inefficiencies and suggest improvements. -/- 8. Pilot Implementation & Nationwide Rollout -/- A. Phase 1: Pilot Program (Years 1-3) -/- Implement holistic education in select regions (Luzon, Visayas, Mindanao) as test sites. -/- Assess effectiveness before nationwide expansion. -/- B. Phase 2: Expansion (Years 4-6) -/- Gradually integrate holistic principles into all public and private schools. -/- Launch teacher retraining programs nationwide. -/- C. Phase 3: Full Implementation (Years 7-10) -/- Make holistic education mandatory across all educational institutions. -/- Implement AI-driven policy monitoring to ensure governance aligns with holistic principles. -/- Conclusion: The Future of Philippine Education -/- By implementing this comprehensive holistic educational system, the Philippines can transform its governance, economy, and societal well-being. This approach will ensure that future generations make decisions based on natural laws, critical thinking, and ethical responsibility—ultimately leading to a more stable and prosperous nation. -/- . (shrink)

Despite having a set of well-intended tobacco control policies since 2003, the production and consumption of tobacco in Bangladesh have increased. This paper explains why the tobacco control policies in Bangladesh failed to deliver their intended outcomes. Using a combined framework of political economy and policy implementation analysis, this study examines the information collected from primary and secondary sources. Based on the findings, the paper argues that the game of interests among the stakeholders have made the state institutions (...) inactive and ineffective. Lack of political commitment and politics of interests have failed the implementation and skewed the outcome. (shrink)

t. This paper presents a sensor-based approach to developing a gesture-controlled robotic vehicle, designed to enhance human-machine interaction in a more intuitive and accessible manner. The system translates hand movements, detected through accelerometers and gyroscopes within a wearable device, into commands that control the vehicle. Traditional methods for operating robotic systems, such as joysticks or remote controls, often require physical interaction, limiting their effectiveness, especially for individuals with disabilities or in environments where hands-free control is essential. This approach offers (...) a non-contact, real-time control mechanism, detecting hand gestures without relying on visual cues, thereby reducing computational load and ensuring stable performance even under varying lighting conditions. The implementation involves sensor calibration, data acquisition, and processing via microcontrollers such as Arduino or ESP32, coupled with a motor control system for vehicle operation. Testing results demonstrate the accuracy and low-latency response of the gesture-based control system. The primary objective is to make this technology widely accessible, offering a scalable solution for various applications, including assistive technologies and robotics. Preliminary findings confirm the system’s effectiveness, opening the door for further real-world applications. (shrink)

This work examines the development and performance of federal independent regulatory bodies in Canada in the period up to 1979, with particular attention to the operation of legislative schemes that include executive review and appeal powers. The author assesses the impact of the exercise of these powers on the administrative law process, and proposes new models for the generation, interpretation, implementation, review, and enforcement of regulatory policy. The study includes a series of representative case studies based on documentation and (...) extensive interviews with individuals drawn from government, agencies, and other parties, including counsel for public interest groups. This enables author, writing from her experience as a participant-observer embedded in the public interest legal sector, to draw on the experiences and perspectives of a broad range of participants in the regulatory process, including but not limited to those dealing with the regulated energy, transportation, communications, and foreign investment sectors. Legal principles identified as emergent in leading judicial decisions in administrative law are used to assess the powers and practices used in executive reviews and appeals. The author finds those powers and practices to be flawed and proposes changes. The proposed models are designed to accord with emerging legal principles and avoid flaws of the types identified in the review and appeal provisions. This work, written under contract with the Administrative Law Project of the Law Reform Commission of Canada, formed one part of a comprehensive study of administrative law at the federal level in Canada. (shrink)

The Nature of Observation: Biological, Non-Biological, or Both? -/- Introduction -/- Observation plays a crucial role in shaping reality, whether in physics, human decision-making, or governance. While classical physics treats observation as a passive act, quantum mechanics suggests it influences reality itself. In human behavior, observation determines how individuals interpret information, make decisions, and interact with the world. -/- A key question arises: Does observation require a biological, conscious observer, or can it be a universal process independent of consciousness? (...) If the universal law of balance governs all natural processes, then observation itself may be a fundamental feedback mechanism that ensures stability in both individual and collective systems. -/- This essay explores observation from three perspectives: -/- 1. Scientific Foundations – How physics and neuroscience explain observation. -/- 2. Practical Applications – The role of observation in leadership, governance, and education. -/- 3. The Nature of the Observer – Whether observation requires biological consciousness or can exist universally. -/- 1. Scientific Foundations of Observation -/- Observation in Physics: Does Reality Depend on an Observer? -/- In classical physics, observation is simply a means of measuring reality, with no impact on the observed system. However, quantum mechanics challenges this view, suggesting that the act of observation itself affects reality. Several interpretations address this: -/- Copenhagen Interpretation – A system remains in a superposition of states until observed, at which point the wave function collapses into a definite outcome. -/- Von Neumann-Wigner Interpretation – Consciousness is required for wave function collapse, implying that a biological observer is necessary. -/- Decoherence and Relational Quantum Mechanics – Observation is merely an interaction between systems, meaning even non-conscious entities, such as measuring devices, can act as observers. -/- From the universal law of balance perspective, observation may function as a self-regulating mechanism that maintains equilibrium. This suggests that observation is not necessarily biological but a universal process embedded in nature. -/- Observation in Neuroscience: How the Brain Interprets Reality -/- In human cognition, observation is more than perception—it is an active process influenced by attention, memory, and prior experiences. Neuroscientific research highlights key aspects of observation: -/- Attention and focus shape perception – What we observe determines the information we process. -/- Cognitive biases influence observation – Our past experiences affect how we interpret reality. -/- Observation creates feedback loops – What we perceive influences future decisions, reinforcing learned behaviors. -/- These findings suggest that free will is not absolute but shaped by observation. Our choices are not purely independent but responses to what we observe and how we interpret those observations. -/- 2. Practical Applications of Observation -/- Observation in Leadership and Governance -/- Leaders rely on observation to make decisions. However, if their observations are distorted, incomplete, or manipulated, they risk making choices that create imbalance. Effective leadership depends on: -/- 1. Accurate Observation – Basing decisions on factual, unbiased information. -/- 2. Objective Decision-Making – Aligning policies with reality rather than personal ideology. -/- 3. Continuous Feedback Loops – Adjusting policies based on new observations to maintain balance. -/- When leaders fail to observe reality accurately—such as ignoring economic warnings, environmental data, or social unrest—their decisions create instability and crisis. Observation, therefore, functions as a balancing force in governance. -/- Observation in Education: Training Minds to Perceive Reality Correctly -/- A well-designed education system should develop strong observational and critical thinking skills to help individuals: -/- Recognize false information – Avoid being misled by propaganda or misinformation. -/- Make rational decisions – Base choices on evidence rather than emotions or biases. -/- Understand cause and effect – See how actions impact society and the environment. -/- When education fails to train individuals in accurate observation, entire societies suffer from poor decision-making, misinformation, and social instability. -/- 4. The Nature of the Observer: Biological, Non-Biological, or Both? -/- Is a Conscious Mind Necessary for Observation? -/- One of the biggest debates in science and philosophy is whether an observer must be biological and conscious or if observation can occur universally, without consciousness. -/- 1. Biological Observation: Conscious Minds as Observers -/- In human decision-making, observation is an active cognitive function that involves perception, analysis, and interpretation. -/- Neuroscience suggests that consciousness plays a role in filtering and processing observations, making human observers unique in their ability to reflect on reality. -/- 2. Non-Biological Observation: Can Reality Observe Itself? -/- In physics, many interpretations suggest that observation does not require a conscious mind. -/- Even inanimate objects—such as measuring devices, environmental interactions, and quantum systems—“observe” by influencing and recording information. -/- Observation as a Universal Principle -/- If we apply the universal law of balance, observation is not just a human ability but a fundamental process that exists at all levels of reality: -/- In physics, observation is an interaction between systems that influences the state of reality. -/- In biology, observation is an evolved function that allows conscious beings to process and respond to their environment. -/- In governance and education, observation is a tool that enables societies to make informed decisions. -/- This suggests that both biological and non-biological observation exist, functioning together to maintain balance in reality. -/- 3. Key Takeaways: Observation as a Balancing Force -/- The Role of Observation in Free Will -/- If decision-making follows the universal law of balance, then free will is not entirely independent—it is shaped by observation. -/- The more accurately we observe reality, the better our decisions. -/- False beliefs and misinformation disrupt free will and lead to imbalance. -/- Observation is a feedback system that ensures decisions remain within natural laws. -/- Observation as a Universal Process -/- In physics, observation is an interaction that shapes reality. -/- In neuroscience, observation affects how the brain processes information. -/- In leadership, observation determines policy success or failure. -/- In education, observation skills shape how individuals make decisions. -/- Final Insights -/- Observation is not passive—it actively shapes reality. -/- Observation does not have to be biological—non-biological processes also “observe” through interaction. -/- The universal law of balance ensures that observation acts as a feedback loop. -/- Improving observation skills leads to better decision-making in all areas of life. -/- Conclusion -/- Observation is a universal process that exists across different scales of reality, from quantum physics to human decision-making. Whether performed by a conscious mind or a non-biological system, observation serves as a feedback mechanism that maintains balance. -/- If observation is distorted—through ignorance, false beliefs, or misinformation—decisions create imbalance, leading to crises at both personal and societal levels. -/- Thus, observation is a fundamental principle of the universe, ensuring that reality operates within the natural laws governing equilibrium. Understanding and improving our ability to observe reality accurately is essential for maintaining balance in both individual consciousness and society as a whole. -/- . (shrink)