We address Steel’s Programme to identify a ‘preferred’ universe of set theory and the best axioms extending ZFC by using his multiverse axioms MV and the ‘core hypothesis’. In the first part, we examine the evidential framework for MV, in particular the use of large cardinals and of ‘worlds’ obtained through forcing to ‘represent’ alternative extensions of ZFC. In the second part, we address the existence and the possible features of the core of MV_T (where T is ZFC+Large Cardinals). In (...) the last part, we discuss the hypothesis that the core is Ultimate-L, and examine whether and how, based on this fact, the Core Universist can justify V=Ultimate-L as the best (and ultimate) extension of ZFC. To this end, we take into account several strategies, and assess their prospects in the light of MV’s evidential framework. (shrink)

RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE A MORTALIDADE EMBRIONÁRIA EM VACAS -/- Emanuel Isaque Cordeiro da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim [email protected] ou [email protected] WhatsApp: (82)98143-8399 -/- •__5. Mortalidade EMBRIONÁRIA -/- A mortalidade embrionária (ME) é uma desordem reprodutiva responsável por cerca de 15% das falhas da gestação. Em si, a ME pode ser dividida em dois grandes grupos, a ME precoce, ou seja, aquela que ocorre nos primeiros dias da gestação, por problemas específicos de reconhecimento materno-fetal, (...) que não geram alteração significativa do ciclo estral, já que, não se afeta o corpo lúteo (BONDURANT, 2004). A segunda forma da ME, denominada ME tardia, altera o ciclo estral e se apresenta por rejeição da implantação em suas primeiras fases, usualmente se apresenta entre 25 e 40 dias pós-serviço. De acordo com GEARY (2005) existem múltiplas causas associadas à ME, entre essas causas listam-se os problemas de rejeição imunológica, a ausência de fatores de reconhecimento materno-fetal, problemas infecciosos, estresse e deficiências nutricionais, sobre essa última pode-se citar: 5.1 Deficiência de betacarotenos Os betacarotenos são precursores da vitamina A (provitamina A). São pigmentos vegetais de cor amarela ou laranja que, uma vez ingeridos, se transformam no fígado e no intestino delgado em vitamina A. São antioxidantes que ajudam o organismo a eliminar os radicais livres tóxicos que causam a oxidação dos tecidos (reação química de peroxidação que produz lesão nos tecidos já que os peróxidos são compostos tóxicos e cancerígenos) em células, proteínas e no material genético como DNA. Os radicais livres são normalmente formados como subprodutos do metabolismo oxidativo energético do organismo. Os betacarotenos atuam atrapalhando estes radicais livres e moléculas de oxigênio livre, e daí parte seu efeito protetor o qual centra-se na defesa da parede epitelial, pois sendo precursores da vitamina A, induzindo a sua síntese protegem a parede epitelial do enfraquecimento das suas membranas, evitando assim a entrada fácil de microrganismos patogênicos que possam, especificamente no caso de uma fêmea gestante, produzir infecções que ataquem o embrião provocando a sua morte, uma vez que aumenta-se a resistência imunológica. Além disso, intervêm também na diferenciação das células estaminais do embrião, evitando que ocorram malformações que possam originar mortalidade embrionária, e também evitando a assimetria do organismo que se está formando. A vitamina A, ajuda na conservação dos epitélios para um funcionamento normal. Uma deficiência desta, produz uma alteração dos epitélios que revestem o aparelho genital, podendo ocasionar diminuição da barreira protetora que formam as membranas, os microrganismos patogênicos podem entrar facilmente, desencadeando a morte do embrião. A vitamina A, atua no momento em que as células tronco do embrião entram em uma área deste, chamada "Nódulo de Hensen", começam a formar três camadas embrionárias de células que dão passagem ao sistema nervoso, digestivo, circulatório e outros sistemas do corpo. Células específicas localizadas nesta zona do embrião utilizam seus cílios (que segregam vitamina A) para criar correntes no fluido que as rodeia e dirigir as células estaminais para o seu destino final. Estas células-tronco, antes de chegar ao nódulo do embrião "não estão orientadas espacialmente e tampouco estão diferenciadas em tecidos concretos" embora depois de cruzar esta porta, recebem ordens genéticas necessárias para se colocarem no interior do organismo em desenvolvimento e conhecerem qual vai ser a sua diferenciação específica. Então a ação desta vitamina faz com que algumas destas células ignorem as instruções de diferenciação esquerda e direita, prosseguindo simetricamente. Segundo isto, em uma deficiência de vitamina A, o aspecto exterior do corpo também acabaria por ser assimétrico perdendo potencial de aceitação na implantação, levando os mecanismos naturais de vigilância de estabilidade celular a sua destruição e, portanto, gerando a ME (TORRES et al., 2002). Os níveis de vitamina A, bem como de outras vitaminas, na alimentação de bovinos de corte ou leite já foram discutidos. Cada animal tem sua particularidade de ingestão diária de vitaminas conforme a idade, sexo, categoria, etc. e que esses requerimentos são, muitas vezes, variáveis conforme a disponibilidade, isto é, pode-se fazer a injeção direta de fármacos em líquido ricos em vitaminas no animal, ou pode-se optar pelo fornecimento nos alimentos concentrados (ração) ou pelos volumosos (gramíneas, forrageiras e leguminosas). Deve-se estar atento para que os níveis não ultrapassem o necessário para que nenhum elemento sobressaia outro e venha a ocasionar afecções além de reprodutivas. 5.2 Relação com a Proteína O excesso de proteína crua na dieta tem sido associada com mortalidade embrionária. Há uma hipótese que sugere que a concentração de LH, e portanto de progesterona, poderiam ser afetadas por elevados níveis de proteína na ração, talvez não de forma direta, porém pela deficiência de energia que os excessos proteicos geram. Existe uma relação estreita entre o excesso de proteína crua e a concentração de progesterona, esta relação é através de uma "exacerbação" do balanço energético negativo em vacas no início da lactação, pela despesa de precursores da glicose e o consumo energético extra que supõe transformar o amônio em ureia (este fato só se relaciona com a proteína degradável no rúmen). Isso ocasionaria um aumento negativo do balanço energético negativo e queda de glicemia, o que seria captado pela hipófise como um sinal negativo para a liberação de LH. Um excesso de proteína tal que reduza os níveis de progesterona e de bTP-1 (proteína trofoblástica), hoje identificada como o Interferão tau (IFN-t), pertencente a uma subclasse dos interferões Ômega, e definidos como fatores de reconhecimento materno-fetal em bovinos, pode causar mortalidade embrionária por volta do 17° dia após a inseminação devido à perda do efeito de ambos os compostos contra a resposta imunitária da mãe (MOREIRA & MORALES, 2001). Os níveis excessivos de proteína na dieta que conduzem a níveis elevados de ureia no sangue reduzem o pH uterino, estimulando assim a produção da prostaglandina F2 alfa (PGF2-α) que, por sua vez, estimula a contratilidade uterina e reduz a viabilidade de implantação do embrião (GALVIS, 2003). Foi também observado que concentrações elevadas de ureia no sangue reduzem a formação de progesterona, alterando a atividade reprodutiva em ambos os casos. A progesterona é uma hormona lipídica que é produzida pelo corpo lúteo sob o estímulo do (IGF-I) e, como foi indicado anteriormente, este fator de crescimento foi igualmente reduzido, uma vez que o potencial genético para a produção de leite aumentou de tal maneira que a redução da concentração de IGF- I pode ser uma das causas da diminuição da concentração da progesterona, por exemplo. Agora, embora considere-se que a hormona do crescimento (HC) regula a síntese de IGF-I no fígado, esta hormona não é eficaz a menos que exista um nível limiar de insulina e esta última também é reduzida em vacas de alta produção no início da lactação (GALVIS, 2003) e em condições de balanço energético negativo, tal como ocorre no pós-parto precoce. As proteínas são essenciais na vida dos animais e do ser humano. Os animais possuem sua particularidade conforme a exigência requerida de proteína e já foi discutido que os melhores métodos para fornecimento racional dessa macromolécula é por meio dos alimentos concentrados ricos em soja que é considerado um alimento proteico por possuir um teor de 60% desta, ou por meio de alimentos volumosos no caso dos capins, silagens, etc. Como já discutido em outros trabalhos, existem tipos diferentes de proteínas com funções também distintas, citamos a proteína bruta (PB) e a proteína metabolizável (PM), ao qual os animais requerem em porcentagens que devem estar presentes no alimento que o criador fornece e que o animal ingere. -/- Apoio -/- Realização -/- •_ _referências bibliográficas -/- BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. BONDURANT, R. H. Controlling what we can control: Limiting embryonic fetal losses. In: Proc. of the American Assn. of Bovine Practitioners Conf. 2004. Vol. 37. p. 2004-2023. CORREA, H. J. El metabolismo del nitrógeno y su relación con las alteraciones reproductivas en vacas de alta producción. II Curso de Actualización en Reproducción Animal, Grupo de Investigación en Biotecnología Aplicada, Politécnico Colombiano Jaime Isaza Cadavid, Medellín, v. 3, 2002. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. GALVIS, Rubén D.; CORREA, Héctor J.; RAMÍREZ, Nicolás. Interacciones entre el balance nutricional, los indicadores del metabolismo energético y proteico y las concentraciones plasmáticas de Insulina, e IGF-1 en vacas en lactancia temprana. Revista Colombiana de Ciencias Pecuarias, v. 16, n. 3, p. 237-248, 2003. GEARY, Tom. Management strategies to reduce embryonic loss. Range Beef Cow Symposium. Lincoln: University of Nebraska, 2005. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. MOREIRA, Olga Lidia; MORALES, C. Efecto del interferón recombinante bovino omega i sobre el intervalo interestral, tiempo de vida del cuerpo luteo y la temperatura corporal en el bovino. Revista de Salud Animal, v. 23, n. 1, p. 56-62, 2001. TORRES, M. et al. Aspectos Farmacológicos relevantes de las Vitaminas Antioxidantes (E, A y C). Archivos Venezolanos de Farmacología y Terapéutica, v. 21, n. 1, p. 22-27, 2002. Emanuel Isaque Cordeiro da Silva Belo Jardim, 29 de março de 2020. (shrink)

Recenzio Kiraly V. Istvan Death and History c. konyverol.

Review the Istvan Kiraly V.'s book: Death and History.

A holobiont is a composite organism consisting of a host together with its microbiome, such as a coral with its zooxanthellae. To explain the often intimate integration between hosts and their microbiomes, some investigators contend that selection operates on holobionts as a unit and view the microbiome’s genes as extending the host’s nuclear genome to jointly comprise a hologenome. Because vertical transmission of microbiomes is uncommon, other investigators contend that holobiont selection cannot be effective because a holobiont’s microbiome is an (...) acquired condition rather than an inherited trait. This disagreement invites a simple mathematical model to see how holobiont selection might operate and to assess its plausibility as an evolutionary force. This paper presents two variants of such a model. In one variant, juvenile hosts obtain microbiomes from their parents (vertical transmission). In the other variant, microbiomes of juvenile hosts are assembled from source pools containing the combined microbiomes of all parents (horizontal transmission). According to both variants, holobiont selection indeed causes evolutionary change in holobiont traits. Therefore, holobiont selection is plausibly an effective evolutionary force with either mode of microbiome transmission. The modeling employs two distinct concepts of inheritance, depending on the mode of microbiome transmission: collective inheritance whereby juveniles inherit a sample of the collected genomes from all parents, as contrasted with lineal inheritance whereby juveniles inherit the genomes from only their own parents. A distinction between collective and lineal inheritance also features in theories of multilevel selection. (shrink)

The authors developed this textbook in response to an increasing interest in ethics, and a growing number of courses on this topic that are now being offered in educational leadership programs. It is designed to fill a gap in instructional materials for teaching the ethics component of the knowledge base that has been established for the profession. The text has several purposes: First, it demonstrates the application of different ethical paradigms (the ethics of justice, care, critique, and the profession) through (...) discussion and analysis of real-life moral dilemmas that educational leaders face in their schools and communities. Second, it addresses some of the practical, pedagogical, and curricular issues related to the teaching of ethics for educational leaders. Third, it emphasizes the importance of ethics instruction from a variety of theoretical approaches. Finally, it provides a process that instructors might follow to develop their own ethics unit or course. * Part I provides an overview of why ethics is so important, especially for today's educational leaders, and describes a multiparadigm approach essential to practitioners as they grapple with ethical dilemmas. * Part II deals with the dilemmas themselves. Ethical dilemmas written by the authors' graduate students bring readers face-to-face with the kinds of dilemmas faced by practicing administrators in urban, suburban, and rural settings in an era full of complexities and contradictions. * Part III focuses on pedagogy and provides teaching notes for the instructor. The authors discuss the importance of self-reflection on the part of both instructors and students, and model how they thought through their own personal and professional ethical codes as well as reflected upon the critical incidents in their lives that shaped their teaching and frequently determined what they privileged in class. (shrink)

Dos filósofos dialogan sobre cómo definir en nuestros días la barbarie desde la filosofía política actual. Barajan para ello tres tipos de respuestas. La respuesta ilustrada es la que considera que la diversidad de concepciones del bien de nuestras sociedades es un hecho pernicioso para el desarrollo de la Humanidad, y que hay que imponer sobre ese batiburrillo de opiniones bárbaras la concepción sobre lo bueno más racional, la que en Occidente se propugna desde la Ilustración dieciochesca. La respuesta liberal, (...) por el contrario, acepta gustosa la pluralidad de concepciones morales y metafísicas de nuestras sociedades, y lo único que propone es evitar la barbarie haciendo que, en las cuestiones sobre cómo organizar nuestra sociedad, estas diferencias queden de lado y se intente encontrar un mínimo acuerdo entre todos. Por último, la respuesta postmetafísica sugiere aceptar que las cosmovisiones sobre el bien y el mundo no pueden quedar tan totalmente aparte de nuestros modos de organizar la sociedad como quiere el liberal; pero para evitar el conflicto bárbarico entre ellas, persigue hacer plausible sobre las demás una concepción concreta, que, a diferencia de la del ilustrado, aspiraría mucho más modestamente a sólo expandir un escepticismo para con el resto de nuestras propias creencias; autoironía que nos abriría al diálogo con las creencias de los demás y evitaría en ese juego de conversaciones la violencia de la imposición bárbara. (shrink)

Abstract In this chapter, we challenge the presupposed concept of innovation in the responsible innovation literature. As a first step, we raise several questions with regard to the possibility of ‘responsible’ innovation and point at several difficulties which undermine the supposedly responsible character of innovation processes, based on an analysis of the input, throughput and output of innovation processes. It becomes clear that the practical applicability of the concept of responsible innovation is highly problematic and that a more thorough inquiry (...) of the concept is required. As a second step, we analyze the concept of innovation which is self-evidently presupposed in current literature on responsible innovation. It becomes clear that innovation is self-evidently seen as (1) technological innovation, (2) is primarily perceived from an economic perspective, (3) is inherently good and (4) presupposes a symmetry between moral agents and moral addressees. By challenging this narrow and uncritical concept of innovation, we contribute to a second round of theorizing about the concept and provide a research agenda for future research in order to enhance a less naïve concept of responsible innovation. (shrink)

Elective mathematics has been an extra mathematics subject for pilot students of Eduardo Barretto Sr. National High School for quite some time now. Through this, many alumni testified how this helped them understand senior high school and college math. However, the teachers have also been struggling with the resources for specific areas of mathematics, such as Business Math, Statistics, Analytic Geometry, Trigonometry, and Calculus. When the pandemic hit the Philippines, contextualized learning material aligned with the Most Essential Learning Competencies (MELC) (...) helped elective mathematics teachers. The contextualized learning material was developed from April to August 2020 and was first validated in February 2021 by the students who participated in the pilot testing. However, following the due process, it was suggested that I revalidate the IDEA-formatted Analytic Geometry and Trigonometry instructional material. It examines Eduardo Barretto Sr. National High School mathematics teachers and SDO Calamba City experts' evaluation of the content's topics, objectives, concepts, directions, and activities and the format's prints, illustrations, design, and layout. Participants' perceptions of learning material were assessed using a 4-point Likert Scale survey. Hence, descriptive quantitative design. Participants were surveyed using a 4-point Likert Scale to assess their learning content impression. The findings reveal that the participants found the format and content of the developed learning material to be very satisfactory. The indicators "localized" and "can be done independently" were viewed as Fair and Satisfactory, respectively. The learning material was enhanced by localizing the activities and giving directions that could facilitate self-learning. (shrink)

This study aimed to determine the health practices among the secondary school teachers during the Covid-19 pandemic in Ichon National High School. This considered the socio - demographic profile of the teachers in terms of age, sex, civil status and teaching load and the extent of practice employed by the teachers in the said health dimensions. A total of 53 teachers from Ichon National High School participated as respondents in the evaluative method of research that consists in three parts questionnaires. (...) The statistical treatment used in the computation and analysis of gathered data to determine the socio-demographic profile of the respondents are the descriptive statistics such as frequency and percentage. As to the significance of health practices during COVID-19 pandemic, Kruskal Wallis and Mann-Whitney U test was used to analyze the significant differences on the extent of practices among the different health dimensions. The very high extent of the implementation on the health practices during COVID-19 pandemic shows that the teachers are frequently practiced the health practices. The highest mean in mental aspect is conclusive that teacher during the pandemic exert effort to stay healthy on this and other areas as well. It is recommended to conduct further study regarding on the health practices among the secondary school teachers. (shrink)

Although the map of technology ethics is expanding, the growing subdomains within it may raise misgivings. In a recent and very interesting article, Sætra and Danaher have argued that the current dynamic of sub-specialization is harmful to the ethics of technology. In this commentary, we offer three reasons to diminish their concern about ethical proliferation. We argue first that the problem of demarcation is weakened if we attend to other sub-disciplines of technology ethics not mentioned by these authors. We claim (...) secondly that the logic of sub-specializations is less problematic if one does adopt mixed models (combining internalist and externalist approaches) in applied ethics. We finally reject that clarity and distinction are necessary conditions for defining sub-fields within ethics of technology, defending the porosity and constructive nature of ethical disciplines. (shrink)

Comentaba en el Prólogo a la 1ª edición que nos cuesta distinguir las técnicas de los métodos y aceptar que la buena investigación clínica es la que se realiza con método riguroso. Este método reposa en cuatro pilares: que la pregunta o cuestión formulada sea relevante, que esté enunciada de manera precisa y operativa, que sea abordada o respondida con el mejor medio disponible en cada circunstancia, y que evite redundancias o repeticiones de cuestiones que ya han sido examinadas por (...) otros investigadores. Añadía que es imprescindible una dosis de curiosidad y de entusiasmo por lo que se examina. Como se ha dicho con frecuencia, el ensayo clínico es, entre los métodos de investigación clínica, el "patrón oro", el que, gracias a su característica inherente (la distribución aleatoria), está sujeto a menores posibilidades de sesgos. Esta consideración no ha cambiado. Sin embargo, mayor validez interna del método no implica mayor relevancia de los resultados obtenidos. Actualmente es común examinar protocolos de ensayos clínicos bien diseñados, cuyo "único" problema es que pretenden evaluar aspectos de escaso interés farmacológico, terapéutico, epidemiológico o sanitario. ¿Qué interés tiene la evaluación del quinto fármaco de una serie en una indicación para la que ya hay cuatro análogos que le han precedido en su desarrollo? ¿Qué interés tiene la evaluación de un nuevo hipocolesterolemiante o de un nuevo fármaco para la osteoporosis si no se conocen, respectivamente, el impacto de la hipercolesterolemia como factor de riesgo de cardiopatía isquémica o la epidemiología de las fracturas en mujeres postmenopáusicas en nuestro medio? En relación con estos ejemplos, tendría mucho más interés conocer los determinantes epidemiológicos y la historia natural de la cardiopatía isquémica en nuestro medio y conocer la epidemiología de las fracturas "espontáneas" y su impacto sobre la demanda asistencial; para ello serían de mucha utilidad métodos de investigación cuya validez intrínseca podría ser considerada "subóptima" en comparación con el ensayo clínico. En los últimos años ha irrumpido con fuerza en numerosísimas publicaciones el concepto de la "medicina basada en pruebas". Esta moda refleja en parte la importancia que de manera creciente reguladores e industria farmacéutica han concedido a los ensayos clínicos: se ha alcanzado un consenso global sobre la necesidad de demostrar la "eficacia" de los nuevos medicamentos por medio de ensayos clínicos controlados. De este modo, los organismos reguladores y autoridades sanitarias exigen ensayos clínicos como uno de los elementos necesarios para obtener el registro de un nuevo medicamento. Como consecuencia, se realizan y publican muchos más ensayos clínicos que antaño, y actualmente se pueden encontrar ensayos que sustentan la eficacia de la mayoría de los medicamentos disponibles en indicaciones específicas. Si hace unos años bastaba con examinar si había ensayos clínicos que demostraran la eficacia de un determinado medicamento antes de adoptarlo como uno de los de uso común (o de incluirlo en el formulario de un hospital), en la actualidad estas decisiones son más complejas, y se basan sobre todo en una consideración atenta de los objetivos, los métodos y los resultados de cada ensayo o de otros estudios destinados a evaluar eficacia, seguridad, conveniencia o comodidad y coste. Un buen clínico debe saber a la vez leer críticamente las publicaciones científicas y producir información relevante. Leer críticamente significa evaluar la pertinencia de los problemas investigados, los métodos aplicados y la interpretación de los resultados obtenidos. Producir información relevante implica saber identificar los problemas que deben y pueden ser objeto de investigación, formularlos, y ser protagonista (generalmente como parte de un equipo) de la elaboración del plan de investigación. En los últimos años se han publicado varios textos similares al que tiene en sus manos, todos ellos de gran calidad. El presente no pretende ser el más exhaustivo, sino sobre todo interesar a los profesionales sanitarios en el apasionante campo de la investigación clínica, en su sentido más amplio, estimulando la autonomía del lector para investigar un problema o una situación, y para aprender a leer las publicaciones científicas clínicas. Su lectura debe contribuir a que términos como "doble ciego", "p<0,05", "casos y controles", etc. dejen de ser fetiches-misterios, para convertirse en herramientas conceptualmente sencillas, útiles para la evaluación de la actividad asistencial. Esta nueva edición está muy ampliada respecto a la anterior. Se han reorganizado las generalidades sobre los objetivos y métodos de la investigación clínica, se han ampliado algunos aspectos del ensayo clínico, como el análisis de subgrupos, los aspectos estadísticos y éticos y las publicaciones sobre ensayos clínicos, se han añadido cuatro nuevos capítulos, sobre efectividad y eficacia, metaanálisis, ensayos en un solo paciente y farmacoeconomía, y el Glosario ha sido revisado y ampliado (sobre todo con términos de farmacocinética, desarrollo preclínico de fármacos, estadística y biotecnología genética), e incluye casi 750 términos. Para su elaboración me he basado en numerosos textos y diccionarios,a aunque he reformulado la mayoría de las definiciones y he optado por añadir en ocasiones algún comentario personal a muchas de ellas. Carles Vallvé ha escrito el capítulo sobre Normas de Buena Práctica Clínica. Agradezco asimismo las precisones y comentarios de Eulalia Dalmau, Javier Jiménez, Josep Maria Castel y Xavier Vidal, así como los comentarios a versiones anteriores de Fernando Antezana y Jorleny Rojas. Eduard Diogène me sugirió la idea de la portada, El sueño de la razón produce monstruos, que Goya comentaba así: " La fantasía abandonada de la razón produce monstruos imposibles: unida con ella es madre de las artes y origen de sus marabillas" La 1ª edición de este libro, que fue promovida por Zeneca, tuvo una amplia difusión, en España y en América Latina. AstraZeneca me propuso preparar esta 2ª edición del mismo modo abierto que en ocasión de la primera; su actual Director Médico Ramón Estiarte me ha ayudado en la selección de términos para el Glosario. A él y al anterior Director Médico de Zeneca, Manuel Martín, agradezco su idea inicial, su estímulo y ayuda, y las facilidades que han dado para la difusión de este libro. Joan-Ramon Laporte. (shrink)

Moral objections have been levied against the market system for as long as it has existed, but there has been relatively little systematic theorizing about what the requirements of a successful objection are. There are at least two strategies for constructing such a requirement. One strategy is to endorse one of the many moral or political theories on offer. But given persistent contestation over the right moral theory, any requirement produced by this strategy will likely be controversial. A second strategy (...) circumvents this problem, and has been pursued in recent work by Jaeggi (2016), Brennan & Jaworski (2022), and Robson (2023a; 2023b). These authors propose requirements which do not depend on any particular moral or political theory. In this paper, I evaluate these proposed requirements, rejecting most on the grounds that they are either too restrictive or unsystematic. (shrink)

In this paper I try to explain a strange omission in Hume’s methodological descriptions in his first Enquiry. In the course of this explanation I reveal a kind of rationalistic tendency of the latter work. It seems to contrast with “experimental method” of his early Treatise of Human Nature, but, as I show that there is no discrepancy between the actual methods of both works, I make an attempt to explain the change in Hume’s characterization of his own methods. This (...) attempt leads to the question about his interpretation of the science of human nature. I argue that his view on this science was not a constant one and that initially he identified this science with his account of passions. As this presupposes the primacy of Book 2 of his Treatise I try to find new confirmations of the old hypothesis that this Book had been written before the Book 1, dealing with understanding. Finally, I show that this discussion of Hume’s methodology may be of some interest to proponents of conceptual analysis. -/- . (shrink)

The analysis of moral subject in consequentialist ethics (as a kind of nonutilitaristic consequentialism) aims to show, that moral subject is of basie importance for it - regardeless to the fact, that its analysis focuses predominantly on action and its concequences. It is the moral subject, which enables the action and its consequences to be performed. So understanding the conditions of moral subjecťs action means understanding the moral subject itself. This understanding draws upon the typology of moral subjects that makes (...) the prediction of certain kinds of action as well as oftheir consequencies possible. (shrink)

In ordеr to invеstigatе thе complеx naturе of cognition and its rеlationships, this rеsеarch articlе looks dееply into thе complеx intеrplay bеtwееn human thoughts and information from a philosophical standpoint. This study еxplorеs how psychology and nеurosciеncе intеrsеct in a philosophical sеtting in an еffort to prеsеrvе thoughts as an еxtеnsion of biology. By еxamining how a piеcе of information dеvеlops from a concеpt to an information hazard, thе rеsеarch еxplorеs thе potеntial еffеcts of hazardous information on both individuals and (...) largе groups. Thе study invеstigatеs thе history of information dangеrs and thеir еffеcts on human survival and moral viеwpoints while drawing inspiration from еvolutionary idеas. Thе kеy quеstion is: in tеrms of survival and morality, arе information hazards an assеt or a cursе? Throughout this rеsеarch, thе papеr sееks to clarify thе complеxity of human cognition and its nuancеd intеraction with information, offеring a philosophical prism through which to sее and discuss thе significant еffеcts of idеas in thе contеmporary еra. (shrink)

Cải cách tiền lương là một trong những nội dung quan trọng sẽ được thảo luận tại Kỳ họp thứ 6, Quốc hội khóa XV và đây cũng là một trong những chìa khoá để mở ra các chính sách đãi ngộ nhằm góp phần xây dựng, phát triển đội ngũ trí thức nước nhà, đáp ứng yêu cầu phát triển đất nước nhanh và bền vững trong giai đoạn mới như nội dung mà Hội nghị Trung ương 8 khoá (...) XIII, Ban Chấp hành Trung ương Đảng đã thảo luận. (shrink)

In this paper we focus our attention on tableau methods for propositional interval temporal logics. These logics provide a natural framework for representing and reasoning about temporal properties in several areas of computer science. However, while various tableau methods have been developed for linear and branching time point-based temporal logics, not much work has been done on tableau methods for interval-based ones. We develop a general tableau method for Venema's \cdt\ logic interpreted over partial orders (\nsbcdt\ for short). It combines (...) features of the classical tableau method for first-order logic with those of explicit tableau methods for modal logics with constraint label management, and it can be easily tailored to most propositional interval temporal logics proposed in the literature. We prove its soundness and completeness, and we show how it has been implemented. (shrink)

This study aims to find out the factors that hinder students in learning Integrated Art Education. A descriptive research design was utilized in the conduct of the study. The researcher prepared a questionnaire with 15 closed-ended- questions that could be answered objectively. The study discovered that the students would learn more when they feel that they belong to a certain group. Interests in a subject also matter, the more you are interested in a particular subject, the more you will learn (...) the material. Parent support marks an impact on the student's interest in learning Arts. Therefore, personal interest in a subject must be given attention and managed properly. Parent's support also plays a vital role in reinforcing the students on what to pursue in order to maintain their motivation. (shrink)

Attempt of trans-disciplinary analysis of the evolutionary value of bioethics is realized. Currently, there are High Tech schemes for management and control of genetic, socio-cultural and mental evolution of Homo sapiens (NBIC, High Hume, etc.). The biological, socio-cultural and technological factors are included in the fabric of modern theories and technologies of social and political control and manipulation. However, the basic philosophical and ideological systems of modern civilization formed mainly in the 17–18 centuries and are experiencing ever-increasing and destabilizing risk-taking (...) pressure from the scientific theories and technological realities. The sequence of diagnostic signs of a new era once again split into technological and natural sciences’ from one hand, and humanitarian and anthropological sciences’, from other. The natural sciences series corresponds to a system of technological risks be solved using algorithms established safety procedures. The socio-humanitarian series presented anthropological risk. Global bioethics phenomenon is regarded as systemic socio-cultural adaptation for technology-driven human evolution. The conceptual model for meta-structure of stable evolutionary strategy of Homo sapiens (SESH) is proposes. In accordance to model, SESH composed of genetic, socio-cultural and techno-rationalist modules, and global bioethics as a tool to minimize existential evolutionary risk. An existence of objectively descriptive and value-teleological evolutionary trajectory parameters of humanity in the modern technological and civilizational context (1), and the genesis of global bioethics as a system social adaptation to ensure self-identity (2) are postulated. -/- . (shrink)

The primary goal of this study is to analyse two extremes of leadership ideologies using philosophical notions as a perspective. It accomplishes this by exploring the leadership goals and the concept of freedom advanced by the Buddha and Christ's leadership views. This research will also look into how their leadership style affects society. Using an objective analysis, this study seeks to shed light on the codependent link between freedom, leadership, and the impact on human morality.

Cuprins INTRODUCERE EXCURSIVĂ 5 CAPITOLUL I SECRETUL CA TEMA A UNEI ANALIZE DE FILOSOF1E APLICATA ...9 Preliminarii 9 /. Schiţa ideii de „aplicare" a fiiosofiei şi a unei „filosofii aplicate" 10 //. Tematica secretului 27 Excurs: Despre temati-are 28 CAPITOL Uli^T) _ ANALIZA CATEGORIALA Şl SECRETUL 40 /. Filosofía aplicată şi analiza categorială 40 //. Secretul şi structura lui categorială 6,5, Excurs: Secret - Privat - Public 70 CAPITOLUL III SECRETUL ŞI SOCIALISMUL 76 Excurs: Fonduri secrete sau fonduri interzise? 90 (...) CAPITOLUL IV FENOMENOLOGIA EXISTENŢIALĂ A SECRETULUI - TENTATIVE DE DIALOG CU MARTIN HEIDEGGER 113 Excurs: Nimicul, Secretul şi Misterul 158 CAPITOLUL V „FOSTELE" SECRETE - „FOSTITATE" ŞI TRECUT 179 Excurs: Despre NICICÂND şi NICIODATĂ 1) Expunerea temporalităţii ..fenomenului culpei" la Heidegger 198 2) Analiza lui „nicicând" şi „niciodată" (nici-când-nici) 201 CAPITOLUL VI IPOSTAZELE SECRETULUI. COMPLOTUL. JURĂMÂNT ŞI SECRET ..229" Excurs: Despre jurământ 233 Excurs: Despre mască 248 APPENDLX: FILOSOFÍA APLICATA ŞI ÎNTREBAREA DESPRE EXISTENŢA Şl POSIBILITATEA FILOSOFULOR NAŢIONALE 258 RESUME 272. (shrink)

In this conceptual paper, the traditional conceptualization of sustainable entrepreneurship is challenged because of a fundamental tension between processes involved in sustainable development and processes involved in entrepreneurship: the concept of sustainable business models contains a paradox, because sustainability involves the reduction of information asymmetries, whereas entrepreneurship involves enhanced and secured levels of information asymmetries. We therefore propose a new and integrated theory of sustainable entrepreneurship that overcomes this paradox. The basic argument is that environmental problems have to be conceptualized (...) as wicked problems or sustainability-related ecosystem failures. Because all actors involved in the entrepreneurial process are characterized by their epistemic insufficiency regarding the solving of these problems, the role of information in the sustainable entrepreneurial process changes. On the one hand, the reduction of information asymmetries primarily aims to enable actors to become critical of sustainable entrepreneurs’ actual business models. On the other hand, the epistemic insufficiency of sustainable entrepreneurs guarantees that information asymmetries remain as a source of new sustainable business opportunities. Three further characteristics of sustainable entrepreneurs are distinguished: sustainability and entrepreneurship-related risk-taking; sustainability and entrepreneurship-related self-efficacy; and the development of satisficing and open-ended solutions, together with multiple stakeholders. (shrink)

The co-evolutionary concept of three-modal stable evolutionary strategy of Homo sapiens is developed. The concept based on the principle of evolutionary complementarity of anthropogenesis: value of evolutionary risk and evolutionary path of human evolution are defined by descriptive (evolutionary efficiency) and creative-teleological (evolutionary correctness) parameters simultaneously, that cannot be instrumental reduced to other ones. Resulting volume of both parameters define the vectors of biological, social, cultural and techno-rationalistic human evolution by two gear mechanism — genetic and cultural co-evolution and techno-humanitarian (...) balance. Explanatory model and methodology of evaluation of creatively teleological evolutionary risk component of NBIC technological complex is proposed. Integral part of the model is evolutionary semantics (time-varying semantic code, the compliance of the biological, socio-cultural and techno-rationalist adaptive modules of human stable evolutionary strategy). (shrink)

Contrary to the tendency to harmony, consensus and alignment among stakeholders in most of the literature on participation and partnership in corporate social responsibility and responsible innovation practices, in this chapter we ask which concept of participation and partnership is able to account for stakeholder engagement while acknowledging and appreciating their fundamentally different judgements, value frames and viewpoints. To this end, we reflect on a non-reductive and ethical approach to stakeholder engagement, collaboration and partnership, inspired by the philosophy of Emmanuel (...) Levinas. We contrast a cognitive approach with an ethical approach to stakeholder engagement, collaboration and partnership, and explore four characteristics of this ethical approach. Based on the ethical approach to stakeholder engagement, collaboration and partnership, we also provide a three-stage framework for partnership formation in CSR and RI practices. (shrink)

Stable adaptive strategy of Homo sapiens (SASH) is a result of the integration in the three-module fractal adaptations based on three independent processes of generation, replication, and the implementation of adaptations — genetic, socio-cultural and symbolic ones. The evolutionary landscape SASH is a topos of several evolutionary multi-dimensional vectors: 1) extraversional projective-activity behavioral intention (adaptive inversion 1), 2) mimesis (socio-cultural inheritance), 3) social (Machiavellian) intelligence, 4) the extension of inter-individual communication beyond their own social groups and their own species in (...) the rest of the world, 5) the symbolic system of communication (symbolic inheritance), 6) spiritualistic trans- formation of emotionally-shaped components of mentality, 7) the dominance of the rationalist thought mentality (enhancer of adaptive inverse 1), 8) a recursive distribution of projective-activity intentions on the man himself his genome, psyche and culture (Adaptive Inversion 2), 9) introversional reorientation of the vector of cognitive activity (adaptive inversion 3). (shrink)

Human simultaneously is the acting person of a few autonomous and interdepending forms of evolutional process. Accordingly, it is possible to select three forms of adaptation and three constituents of evolutional strategy of survival of humanity – biological, sociocultural and technological adaptations. The actual and potential consequences of development of so-called High Hume technologies (technologies of the guided evolution)  most essential from major technological adaptations of humanity  are analyzed. The phenomenon of bio-power within the framework of global coevolutional (...) methodology as one of central elements of mechanism of mutual co-ordination of biological and sociocultural forms of evolutional process from one side and technocultural balance, with other is examined. (shrink)

The real form of all of us is existence. The reflections of the sun, caught in the millions of waves and bubbles, are nothing but the reflection of the self-same sun. Similarly, the Sat alone is perceived whether as objects of our walking state, or the ideas of dream or undifferentiated consciousness of dreamless sleep.

Purpose (metatask) of the present work is to attempt to give a glance at the problem of existential and anthropo- logical risk caused by the contemporary man-made civilization from the perspective of comparison and confronta- tion of aesthetics, the substrate of which is emotional and metaphorical interpretation of individual subjective values and politics feeding by objectively rational interests of social groups. In both cases there is some semantic gap pre- sent between the represented social reality and its representation in perception (...) of works of art and in the political doctrines as well. Methodology of the research is evolutionary anthropological comparativistics. Originality of the conducted analysis comes to the following: As the antithesis to biological and social reductionism in interpretation of the phenomenon of bio-power it is proposed a co-evolutionary semantic model in accordance with which the de- scribed semantic gap is of the substantial nature related to the complex module organization of a consistent and adaptive human strategy consisting of three associated but independently functional modules (genetic, cultural and techno-rational). Evolutionary trajectory of all anthropogenesis components including civilization cultural and so- cial-political evolution is identified by the proportion between two macro variables – evolutionary effectiveness and evolutionary stability (sameness), i.e. preservation in the context of consequential transformations of some invari- ants of Homo sapiens species specificity organization. It should be noted that inasmuch as in respect to human, some modules of the evolutionary (adaptive) strategy assume self-reflection attributes, it would be more correctly to state about evolutionary correctness, i.e. correspondence to some perfection. As a result, the future of human nature de- pends not only on the rationalist principles of ethics of Homo species (the archaism of Jurgen Habermas), but also on the holistic and emotionally aesthetic image of «Self». In conclusion it should be noted that there is a causal link between the development of High Hume (NBIC) technologies and the totality of the trend in the anthropological phenomenon of bio-power that permeates all the available human existence in modern civilization. As a result, there is a transformation of a contemporary social (man-made) risk in the evolutionary civilization risk. (shrink)

Because the techno-economic paradigm of contemporary conceptualizations of innovation is often taken for granted in the literature, this chapter opens up this self-evident notion. First, the chapter consults the work of Joseph Schumpeter, who can be seen as the founding father of the current conceptualization of innovation as technological and commercial. Second, we open up the concept by reflecting on two aspects of Schumpeter’s conceptualization of innovation, namely its destructive and its constructive aspect, based on findings in the history of (...) innovation. Finally, we synthesize our findings and propose an ontic-ontological conceptualization of innovation as ontogenetic process and outcome with six dimensions—newness, political dimension, economic dimension, temporal dimension, human dimension and risk—that moves beyond its technological and commercial orientation. (shrink)

Stable adaptive strategy of Homo sapiens (SESH) is a superposition of three different adaptive data arrays: biological, socio-cultural and technological modules, based on three independent processes of generation and replication of an adaptive information – genetic, socio-cultural and symbolic transmissions (inheritance). Third component SESH focused equally to the adaptive transformation of the environment and carrier of SESH. With the advent of High Hume technology, risk has reached the existential significance level. The existential level of technical risk is, by definition, an (...) evolutionary risk as possible leads to the genesis of disappearance of humanity as a species. The emergence of bioethics has to consider as a form of modern (transdisciplinary) scientific concept and sociocultural adaptation for regulate human identity in the global-evolutionary transformation and performs the function of self-preservation. (shrink)

The sociobiological and socio-political aspects of human existence have been the subject of techno-rationalistic control and manipulation. The investigation of the mutual complementarity of anthropological and ontological paradigms under these circumstances is the main purpose of present publication. The comparative conceptual analysis of the bio-power and bio-politics in the mentality of the modern technological civilization is a main method of the research. The methodological and philosophical analogy of biological and social engineering allows combining them in the nature and social implications (...) as part of a High Hume technologies class. As result of the transformation of somatic foundations of the human being and his behavior, stereotypes in the object of control and management the technogenic risk reached the existential level. The rapidly growing status of biopower and biopolitics in the conceptual field of contemporary political science becomes by phenomenological expression of these processes. (shrink)

Sources of evolutionary risk for stable strategy of adaptive Homo sapiens are an imbalance of: (1) the intra-genomic co-evolution (intragenomic conflicts); (2) the gene-cultural co-evolution; (3) inter-cultural co-evolution; (4) techno-humanitarian balance; (5) inter-technological conflicts (technological traps). At least phenomenologically the components of the evolutionary risk are reversible, but in the aggregate they are in potentio irreversible destructive ones for biosocial, and cultural self-identity of Homo sapiens. When the actual evolution is the subject of a rationalist control and/or manipulation, the magnitude (...) of the 4th and 5th components of the evolutionary risk reaches a level of existential significance. (shrink)

In order to strengthen RI in the private sector, it is imperative to understand how companies organise this process, where it takes place, and what considerations and motivations are central in the innovation process. In this chapter, the questions of whether and where normative considerations play a role in the innovation process, and whether dimensions of RI are present in the innovation process, are addressed. In order answer these research questions, a theoretical framework is developed based on Jones’s theory of (...) ethical decision making and Cooper’s stagegate model of innovation management. In order to answer the research questions, a specific case of innovations that contribute to public health is explored, namely, that of food companies that participate in a Front-of-Pack logo for healthier food. As the use of healthy food logos does not necessarily have a positive impact on sales and profits, it is expected that in the decision-making process, as part of their innovation process, companies make several trade-offs between economic, technical and moral factors. As the social-ethical values at stake in corporate innovation processes have remained to a large extent unexplored in research on innovation management, the aim of this chapter is to identify the motivations and barriers for companies embracing and continuing a FoP logo for healthier food, and to assess whether ethical considerations play a role in this innovation process. From the findings in this research, it will become clear that although the studied companies participated in a programme for healthy food and thus are responsive to the needs of society, and although the companies feel responsible for public health, ethical considerations do not play a central role in the operational innovation process. Instead, technical and economic considerations seem to prevail in the operational innovation process. Furthermore, none of the procedural dimensions of RI seems to be present at this level in the innovation trajectory. It is argued that this may be an indication that the ethical decision-making process for RI is not located at the level of the operational innovation process itself, but is something that might be located on a higher strategic level in the company. It is at this level that the moral decision is taken to adopt the FoP logo and to engage in the RI process. The findings cast a new light on the discourse on RI in general, and in the private sector in particular. (shrink)

„...nem egy általában vett szerző -/- szól az általában vett olvasóhoz..." -/- Fehér M. István1 -/- -/- „A filozófia a legmélyebb, legfölkavaróbb -/- kérdésekkel hivatott foglalkozni. -/- Végleges megoldásukat nehezen élné túl." -/- Hajós József 2 -/- -/- -/- Egyre több írás – iromány – hermeneutikai szituáltságát konstituálják manapság a „tudományos konferenciák". Gyakran persze ezek „helyettesítik" be a tapasztalatot, a tapasztalat élő kihívásait is. Úgyhogy meglehetősen ritkaságszámba megy az olyan esemény, amikor egy-egy előadás valóságos konferencia-szerű alkalma és tényleges visszhangja igazán (...) találkoznak azzal a szervességgel, amelynek a lehetőségeit rajtuk – azaz, voltaképpen: esetlegességükön – kívül mindig sok más egyéb vonatkozás is artikulál. (shrink)

En aquest article es presenten dues teories sobre la naturalesa del temps i s’analitzen objeccions que s’hi han presentat els darrers anys en el marc de la filosofia analítica. La primera sosté que el passat i el futur no són reals, i presenta el problema de com es poden expressar proposicions veritables sobre temps no presents. D’acord amb la segona teoria, per contra, tots els temps —present, passat i futur— són igual de reals, però això sembla implicar que el futur (...) sigui tan determinat i inexorable com el passat... L’autor clou amb una reflexió entorn de la manera de fer de la filosofia analítica i dels horitzons d’aquesta tradició. (shrink)

The embedding and promotion of social change is faced with aparadoxical challenge. In order to mainstream an approach to socialchange such as responsible research and innovation and makeit into a practical reality rather than an abstract ideal, we need tohave conceptual clarity and empirical evidence. But, in order to beable to gather empirical evidence, we have to presuppose that theapproach already exists in practice. This paper proposes a social labmethodology that is suited to deal with this circularity. Themethodology combines the (...) defining features of social labs emergingfrom the literature such as agility and real-world focus withestablished theories and approaches such as action research andexperiential learning. Thereby it enables the parallel investigationand propagation of RRI. The framework thus constructed provides atheoretical embedding of sociallabs and overcomes some of theknown limitations of the constitutive approaches. (shrink)

The chapters of the book are seemingly short, but deep explorations on the various fields and possibilities of human being and existence. Such explorations of course reorder and reformulate the timely and essential possibilities of philosophy and philosophizing. These together convey the true weight and stakes of things. For it is indeed so that: „Philosophy is destined to deal with the Deepest and most disturbing questions. It would hardly survive, if they were definitively solved.”.

Metaphysical analysis of the Death and the Dying!

Smart Farming Technologies raise ethical issues associated with the increased corporatization and industrialization of the agricultural sector. We explore the concept of biomimicry to conceptualize smart farming technologies as ecological innovations which are embedded in and in accordance with the natural environment. Such a biomimetic approach of smart farming technologies takes advantage of its potential to mitigate climate change, while at the same time avoiding the ethical issues related to the industrialization of the agricultural sector. We explore six principles of (...) a natural concept of biomimicry and apply these principles in the context of smart farming technologies. (shrink)

In this publisher's preface to 'Beobachtungen über den Geist des Menschen und dessen Verhältniß zur Welt' - outstanding, but, despite its merits, so far almost totally unknown philosophical treatise of the late Enlightenment, published in 1790 under a pseudonym 'Andrei Peredumin Koliwanow', I show that the real author of this book was an educator Christlieb Feldstrauch (1734 - 1799).

This book is a translation of W.V. Quine's Kant Lectures, given as a series at Stanford University in 1980. It provide a short and useful summary of Quine's philosophy. There are four lectures altogether: I. Prolegomena: Mind and its Place in Nature; II. Endolegomena: From Ostension to Quantification; III. Endolegomena loipa: The forked animal; and IV. Epilegomena: What's It all About? The Kant Lectures have been published to date only in Italian and German translation. The present book is filled out (...) with the translator's critical Introduction, "The esoteric Quine?" a bibliography based on Quine's sources, and an Index for the volume. (shrink)

Amidst the challenges that teachers are facing nowadays, teachers resiliency in this new tough learning environment seemed to be an unexplored area. Thus, it is crucial to conduct studies that would explore factors that increase teachers resiliency particularly amidst teachers work-related stress and emotional exhaustion. This study explores the moderating effect of social support to self- efficacy and stress management strategies toward teachers resiliency employing descriptive-correlational with moderation design. teachers resiliency. The respondents were one hundred one (101) public elementary school (...) teachers who are currently associated with the four (4) public elementary schools in San Francisco District for the school year 2022-2023 using online survey questionnaire as the main instrument in gathering the data. The findings revealed that both teachers self-efficacy and stress management strategies have a significant relationship in teachers resiliency. This suggests that teachers must also be persistent in strengthening their self-efficacy and developing their stress management strategies to sustain their resiliency. Results also showed that social support effectively moderates the relationship between self-efficacy and teachers resilience. At the same time, it indicated that the higher self-efficacy of teachers was associated with a lower level of social support. Likewise, social support effectively moderates the relationship between stress management strategies and teachers resilience. Results also indicated that the higher level of stress management strategies was associated with lower level of social support. Individuals in the workplace especially supervisors and co-workers must consider providing their colleagues especially those with lower level of self- efficacy and stress management strategies with the necessary social support that they need to be resilient. (shrink)

The pacemaker-accumulator model provides a framework in which the results of different duration estimation tasks are commonly accounted for. Nevertheless, the model remains abstract and it does not provide proper explanations nor predictions for duration estimations in various experimental set-ups. This paper aims to address these shortcomings by explicating an experiential pacemaker-accumulator model that supplements the standard pacemaker-accumulator model with two claims. Both of them concern the role that experiences play in duration estimation tasks and are also partly supported by (...) studies not directly related to duration estimation. First, the internal responses based on which the switch between the pacemaker and the accumulator operates are the same as the neural processes that realize conscious access to experiences. Second, the processes that realize the experiences of stimuli realize the function of the pacemaker. By supplementing the standard pacemaker-accumulator model with these claims, the model affords proper explanations for the systematic errors and empirically testable predictions in duration estimations tasks. One likely consequence of the model is that the experience of duration and the duration of experience can differ. (shrink)