Initial responses to questionnaires used to assess participants' understanding of informed consent for malaria vaccine trials conducted in the United States and Mali were tallied. Total scores were analyzed by age, sex, literacy (if known), and location. Ninety-two percent (92%) of answers by United States participants and 85% of answers by Malian participants were correct. Questions more likely to be answered incorrectly in Mali related to risk, and to the type of vaccine. For adult participants, independent predictors of higher scores (...) were younger age and female sex in the United States, and male sex in Mali. Scores in the United States were higher than in Mali (P = 0.005). Despite this difference participants at both sites were well informed overall. Although interpretation must be qualified because questionnaires were not intended as research tools and were not standardized among sites, these results do not support concerns about systematic low understanding among research participants in developing versus developed countries. (shrink)

Strange Tools foregoes stolid conventions of professional philosophy, laudably broadening the book’s appeal to accommodate a popular audience. However, Noë’s manner of glossing over complex issues about art does not necessarily render these topics intelligible to philosophical novices. Instead, his oversimplifications will tend to confirm naïve notions that art is straightforward – a common misconception that a foray into philosophy of art ought to dispel, not corroborate.

Kant describes the understanding as a faculty of spontaneity. What this means is that our capacity to judge what is true is responsible for its own exercises, which is to say that we issue our judgments for ourselves. To issue our judgments for ourselves is to be self-conscious – i.e., conscious of the grounds upon which we judge. To grasp the spontaneity of the understanding, then, we must grasp the self-consciousness of the understanding. I argue that what Kant requires for (...) explaining spontaneity is a conception of judgment as an intrinsic self-consciousness of the total unity of possible knowledge. This excludes what have been called ‘relative’ accounts of the spontaneity of the understanding, according to which our judgments are issued through a capacity fixed by external conditions. If so, then Kant conceives of understanding as entirely active. Or, to put it another way, he conceives of this capacity as absolutely spontaneous. (shrink)

A World of Muscle, Bone & Organs: Research and Scholarship in Dance is an e-book exploring contemporary ideas and themes in the research and practice of dance. It contains 23 chapters written by researchers at the Centre for Dance Research (C-DaRE), Coventry University, and is divided into six sections: Spaces of Practice, Philosophy, Communities, Politics, Data and Thinking, and Epistemology.

This book presents Robert S. Hartman’s formal theory of value and critically examines many other twentieth century value theorists in its light, including A.J. Ayer, Kurt Baier, Brand Blanshard, Paul Edwards, Albert Einstein, William K. Frankena, R.M. Hare, Nicolai Hartmann, Martin Heidegger, G.E. Moore, P.H. Nowell-Smith, Jose Ortega y Gasset, Charles Stevenson, Paul W. Taylor, Stephen E. Toulmin, and J.O. Urmson.

The “scarred villain” trope, where facial differences like scars signify moral corruption, is ubiquitous in film (e.g., Batman’s The Joker). Strides by advocacy groups to undermine the trope, however, suggest cinematic representations of facial differences could be improving with time. This preregistered study characterized facial differences in film across cultures (US vs. India) and time (US: 1980-2019, India: 2000-2019). Top-grossing films by country and decade were screened for characters with facial differences. We found that the scarred villain trope has actually (...) worsened with time, although in tandem with progress in also representing non-villainous characters with facial anomalies. Country of origin did not predict the presence of facial differences in villains or heroes. “Action” and “fantasy” movies were the most likely genres to depict villains with facial differences. Finally, villains’ facial differences crossed more facial subunits and were more likely to involve lips, chin, and mandible than when present in heroes. Our findings underscore the need for critical reflection on the role of cultural practices—even when seemingly innocuous—in shaping and maintaining negative biases against already stigmatized groups. (shrink)

I. EXECUTIVE SUMMARY The MRCT Center Post-trial Responsibilities: Continued Access to an Investigational Medicine Framework outlines a case-based, principled, stakeholder approach to evaluate and guide ethical responsibilities to provide continued access to an investigational medicine at the conclusion of a patient’s participation in a clinical trial. The Post-trial Responsibilities (PTR) Framework includes this Guidance Document as well as the accompanying Toolkit. A 41-member international multi-stakeholder Workgroup convened by the Multi-Regional Clinical Trials Center of Brigham and Women’s Hospital and Harvard University (...) (MRCT Center) developed this Guidance and Toolkit. Project Motivation A number of international organizations have discussed the responsibilities stakeholders have to provide continued access to investigational medicines. The World Medical Association, for example, addressed post-trial access to medicines in Paragraph 34 of the Declaration of Helsinki (WMA, 2013): “In advance of a clinical trial, sponsors, researchers and host country governments should make provisions for post-trial access for all participants who still need an intervention identified as beneficial in the trial. This information must also be disclosed to participants during the informed consent process.” This paragraph and other international guidance documents converge on several consensus points: • Post-trial access (hereafter referred to as “continued access” in this Framework [for terminology clarification – see definitions]) is the responsibility of sponsors, researchers, and host country governments; • The plan for continued access should be determined before the trial begins, and before any individual gives their informed consent; • The protocol should delineate continued access plans; and • The plan should be transparent to potential participants and explained during the informed consent process. -/- However, there is no guidance on how to fulfill these responsibilities (i.e., linking specific responsibilities with specific stakeholders, conditions, and duration). To fill this gap, the MRCT Center convened a working group in September of 2014 to develop a framework to guide stakeholders with identified responsibilities. This resultant Framework sets forth applicable principles, approaches, recommendations and ethical rationales for PTR regarding continued access to investigational medicines for research participants. (shrink)

INTRODUÇÃO O anestro pós-parto é o período após o parto no qual a fêmea não apresenta ciclos estrais (atividade cíclica). Na vaca leiteira, o parto é seguido de um período de inatividade ovariana de duração variável, que é principalmente afetada pelo estado nutricional, produção leiteira, ganho ou perda de condição corporal antes e depois do parto, e por condições patológicas como hipoplasia dos ovários, cistos ovarianos, mumificação uterina, piometra entre outras, além, também, de condições ambientais como instalações que podem causar (...) estresse etc. 1. Controle neuroendócrino do anestro Entre os 12 e 15 dias pós-parto, as células gonadotróficas presentes na adenohipófise começam a produzir e secretar o FSH (hormônio folículo estimulante), o qual estimula a primeira onda folicular; entretanto, nenhum folículo dominante do(s) ovário(s) chega a completar seu desenvolvimento devido à carência de estímulo apropriado do LH (hormônio luteinizante) que também é produzido pelas mesmas células e que deve estar presente em altas concentrações. Nas 2 primeiras semanas pós-parto (primeiros 15 dias), as concentrações circulantes de LH são baixas, o que se deve à ausência de reservas do LH e à incapacidade temporal da hipófise para responder ao estímulo da GnRH (hormônio liberador de gonadotrofina). Entre os dias 15 e 20 pós-parto, a hipófise aumenta a sua capacidade para responder ao GnRH; entretanto, o estabelecimento do padrão de secreção do LH adequado para estimular a maturação e a ovulação do folículo dominante das primeiras ondas foliculares depende fundamentalmente do balanço energético. 2. Fatores que determinam o início da atividade ovariana pós-parto Na vaca leiteira, é frequente que algum dos primeiros folículos dominantes que se desenvolvem durante as primeiras duas ou três semanas complete a sua maturação e chegue à ovulação, isto é, madure e ovule. O fator limitante para o reinício da atividade ovariana é o balanço energético negativo (BEN). No gado leiteiro, o consumo de matéria seca (CMS), após o parto, deverá ser aumentado em até quatro vezes, para cobrir a demanda de nutrientes para a produção de leite e mantença; no entanto, a vaca é incapaz de consumir a exigência de matéria seca, por isso recorre a suas reservas de gordura e proteína, e cai em BEN. As vacas que consomem menos matéria seca, produzem menos leite, têm um BEN mais profundo e o período do parto à primeira ovulação é maior. O nível mais baixo do BEN é alcançado entre os 10 a 20 dias pós-parto e a vaca continua em BEN até os 70 a 80 dias pós-parto e, em alguns casos, até aos 100 dias pós-parto (vacas primíparas). Entretanto, mesmo com BEN, uma proporção elevada das vacas inicia sua atividade ovariana normal nas primeiras 8 semanas pós-parto. As vacas que alcançam um nível baixo de BEN rapidamente e saem deste ponto mínimo de forma rápida, iniciam sua atividade ovariana mais rápido também (20 a 30 dias pós-parto) do que aquelas que têm um BEN mais profundo e duradouro, essas muitas vezes permanecem em anestro aos 70 dias pós-parto (figura 1). As mudanças na condição corporal estão correlacionadas positivamente com as concentrações séricas de insulina, IGF-I e leptina; assim, a maior qualificação da condição corporal é maior mediante a concentração sérica desses hormônios, que atuam principalmente como sinais que chegam ao hipotálamo e modificam a frequência de secreção do GnRH e, consequentemente, de LH. A leptina é um hormônio que é produzido pelos adipócitos e tem sido proposto que sua concentração é o sinal mais importante de alterações de condição corporal. A transição do anestro para a ciclicidade coincide com um aumento das concentrações séricas de insulina, IGF-I e leptina. Além das mensagens dadas pelos hormônios supracitados, outras substâncias presentes no sangue fornecem informações sobre o estado metabólico do animal. Por exemplo, os ácidos graxos não esterificados e o β-hidroxibutirato são indicadores da mobilização e utilização da gordura corporal; assim, o aumento destas substâncias proporciona uma mensagem inibidora de reprodução. O intervalo médio entre o parto e a primeira ovulação, em vacas leiteiras em sistemas de produção não intensiva, é em torno de 30 dias; enquanto em vacas em sistemas de produção intensiva, é de 40 dias. Deve-se sinalar que é comum aos 70 dias pós-parto, que 20% das vacas ainda não ovulem. Verifica-se frequentemente que as vacas leiteiras desenvolvem folículos que crescem mais que os folículos ovulatórios, os quais convertem em cistos foliculares. Esta condição está associada com insensibilidade do hipotálamo ao retorno positivo do estradiol, o que não desencadeia o pico pré-ovulatório de LH (figura 2). 3. O corpo lúteo dos primeiros ciclos pós-parto Durante um ciclo estral o corpo lúteo tem uma meia-vida fisiológica de 12 a 14 dias; no entanto, na primeira ovulação pós-parto cerca de 25% das vacas desenvolvem corpos lúteos de vida curta (<10 dias), 30% de vida longa (21 a 50 dias) e 45% da vida normal (11 a 20 dias). A regressão prematura do corpo lúteo é uma condição frequente nos ruminantes no primeiro ciclo estral, da transição do anestro à ciclicidade. Ou seja, na vaca é frequente que no primeiro ciclo de pós-parto e da puberdade sejam ciclos curtos; isto deve-se à liberação antecipada da PGF2α. Por outro lado, a causa dos corpos lúteos de vida longa (corpos lúteos persistentes) não é clara, mas está relacionada com alterações na secreção da PGF2α devido a infecções uterinas (tabela 1). 4. Anestro patológico 4.1 Alterações do aparelho genital que causam anestro Na vaca foi calculado que as alterações do aparelho genital que afetam a atividade ovariana representam apenas 10% do total das causas de anestro. Entre as alterações do aparelho genital se encontram os cistos foliculares, cistos luteinizados, aplasia segmentar, piometra e mumificação fetal. . 4.2 Cistos foliculares Os cistos foliculares são a patologia ovariana mais comum nos bovinos leiteiros, causando perdas econômicas devido ao atraso do período do parto ao primeiro serviço, pelo custo dos tratamentos e pelo risco que têm as vacas de serem descartadas. A incidência aumentou à medida que a produção de leite se intensificou. Entre 5 e 30% das vacas desenvolvem cistos foliculares nos primeiros 60 dias do pós-parto; no entanto, cerca de 60% destas se recuperam espontaneamente. Sinais clínicos de vacas com cistos foliculares descritos na literatura são: ninfomania, ciclos curtos, masculinização e relaxamento dos ligamentos pélvicos. Atualmente uma alta proporção de vacas com cistos foliculares apresentam anestro. Por muitos anos um cisto folicular foi definido como um folículo com um diâmetro de 2,5 mm, presente em um ou em ambos os ovários durante um período mínimo de 10 dias, na ausência de um corpo lúteo. Os conhecimentos atuais modificaram o conceito clássico; assim, nem todos os cistos foliculares têm um diâmetro de 2,5 mm; além disso, alguns podem persistir mais de 10 dias. Outros são estruturas dinâmicas, que sofrem regressão e podem ser substituídas por novos cistos. Por esta razão, a definição mais precisa e técnica de um cisto folicular é: folículo de um diâmetro, de pelo menos 20 mm, que está presente em um ou ambos os ovários na ausência de tecido lúteo que interfere com o ciclo estral normal (figura 3). A patogênese dos cistos foliculares não é conhecida. Propõe-se que as vacas que desenvolvem esta patologia têm uma anomalia nos mecanismos de retroalimentação entre o hipotálamo e a hipófise, em conjunto com uma disfunção a nível folicular. É pesquisado e sugerido que em vacas com cistos foliculares, o pico pré-ovulatório de LH não ocorre ou é de menor amplitude, ou não tem uma relação síncrona com o amadurecimento do folículo, o que provoca a falha ovulatória. A alteração na secreção de LH pode obedecer a falta de sensibilidade do hipotálamo ao feedback positivo de estrogênio. Observa-se também que algumas anormalidades a nível folicular, tais como alterações na síntese de hormônios esteroides e uma menor sensibilidade à LH, podem contribuir com a patogenia. Uma vez que o cisto folicular foi estabelecido, observou-se um aumento na frequência de secreção pulsátil de LH, o que contribui com a persistência desta patologia. Existem fatores associados com a incidência de cistos foliculares que, de acordo com a patogenia proposta, podem influenciar ao nível do eixo hipotálamo-hipófise-ovário. Os cistos foliculares ocorrem principalmente durante a transição do anestro pós-parto para a ciclicidade. Neste período as vacas estão em BEN, e tem sido observado que as vacas que sofrem de um BEN mais profundo tendem a apresentar uma incidência maior de cistos foliculares. Por outra parte, há uma correlação positiva entre a produção de leite e a incidência de cistos, o que indica que as vacas que produzem mais leite têm maior risco de sofrer com esta patologia. Também existem outros fatores relacionados com a incidência de cistos foliculares tais como estresse, genéticos, infecções uterinas, estresse calórico e presença de fitoestrogênios na dieta (tabela 2). O tratamento indicado consiste na administração do GnRH, que provoca a luteinização do cisto. É recomendável a combinação com uma dose luteolítica de PGF2α, 7 a 10 dias depois da injeção de GnRH. Também é indicado o tratamento com hCG em vez de GnRH. Em alguns estudos foi possível integrar vacas com cistos foliculares em programas de sincronização da ovulação e inseminação em tempo fixo, com resultados aceitáveis de fertilidade (figura 4). 4.3 Cistos luteinizados Esse tipo de cisto pode se desenvolver a partir de um cisto folicular, também ocorre quando o saco libera um óvulo e, em seguida, se fecha novamente e enche-se de líquido. O tecido luteinizado produz progestágenos do qual os sinais incluem anestro persistente. São bastante mais raros e originam-se pelo contínuo aumento do espaço cavitário central normalmente existente nos corpos lúteos (figura 5). Normalmente, a parede do cisto contém células lúteogranulosas grandes e células tecaluteais pequenas. Se diferenciam com dificuldade de corpos lúteos recém-formados durante o período em que ainda possuem um antro. Os cistos luteínicos únicos, pelo menos os menores, necessitam de importância clínica. Se os cistos são funcionais, a sintomatologia mais destacada é o anestro ou pseudogestação. É preciso lembrar que esses cistos agem como uma fonte de secreção contínua de progesterona, diminuindo assim a resistência do útero a infecções, podendo desencadear-se uma endometrite (figura 6). Se eles forem diagnosticados é recomendável a administração de PGF2α. 4.4 Aplasia segmentar As vacas com esta condição podem gestar quando a ovulação ocorre do lado do corno uterino presente. Se a ovulação acontece do lado onde falta o corno uterino causa anestro. 4.5 Piometra A piometra, por definição, é a acumulação de material purulento no interior da luz uterina que ocorrem geralmente durante ou imediatamente após o período de domínio da progesterona. É uma condição que ocorre mais frequentemente nos primeiros 30 dias pós-parto; no entanto, algumas vacas em anestro que são revisadas no dia 50 pós-parto chegam a ter piometra. O tratamento indicado consiste na administração de PGF2α. 5. Anestro relacionado com o tempo de serviço O anestro em bovinos também é classificado como anestro pré-serviço e pós-serviço. 5.1 Anestro pré-serviço Inclui vacas e novilhas que não tenham mostrado estro, isto é, manifestado cio, no período em que devem ser servidas. Em alguns estudos observou-se que o anestro antes do serviço pode afetar até 50% das vacas elegíveis para apresentar estro. 5.1 Anestro pós-serviço Neste grupo incluem-se as vacas que não retornam ao estro, ou seja, que não retornaram ao cio, 21 dias depois da inseminação e não estão prenhes. Essas vacas são conhecidas como vacas fantasma (The Phantom Cow). A causa principal do atraso do retorno ao estro é a baixa eficiência na detecção de estros; mas também foram descritas outras causas como: inseminação em um estro anovulatório, inseminação em tempo fixo em vacas em anestro, suspensão da ciclicidade após o serviço, fases lúteas longas e morte embrionária. O diagnóstico precoce da gestação é de grande ajuda para conhecer oportunamente o número de fêmeas que não estão prenhes. A ecografia no trigésimo dia pós-inseminação adianta, pelo menos 10 dias, a ressincronização de vacas vazias. 6. Falso anestro ou anestro funcional Este causa as maiores perdas econômicas de caráter reprodutivo em rebanhos leiteiros, e refere-se às vacas que estão ciclando, mas não são observadas em estro pelos trabalhadores. É um dos maiores problemas dentro de um sistema de criação extensivo e, às vezes, semiintensivo, uma vez que é de suma importância a observação técnica e precisa do comportamento da vaca para observar o possível retorno ao cio ou não. 7. Manejo da vaca anéstrica A probabilidade de que a vaca seja inseminada oportunamente depende da eficiência da detecção de estros. É comum que a metade das vacas apresentem estro e não sejam observadas, por essa razão, muitas não são inseminadas uma vez que termina o período de espera voluntária. Por outro lado, há vacas que, por causas patológicas ou por seu estado metabólico, ainda estão em anestro depois que termina o período voluntário de espera. Para identificar as causas da ausência de estros, todas as vacas que não tenham sido inseminadas no dia 60 pós-parto, devem ser revisadas por via retal para aplicar o tratamento ou manejo pertinentes. Durante esta revisão é dada especial atenção às características do útero e nas estruturas ovarianas, já que daqui depende o manejo subsequente. A palpação começa no útero; neste é importante determinar se não há gestação. Posteriormente, avalia-se sua consistência que pode ser normal, edematosa ou turgente. Depois de avaliar o útero procede-se a palpação dos ovários, começando com o direito e, em seguida, esquerdo. Abaixo estão descritas as diferentes descobertas que podem ser encontradas na literatura e seu tratamento ou manejo. O registo dos resultados à palpação é feito através de chaves reprodutivas. 7.1 UN CLD2-3 FE10 Útero normal (UN) com um corpo lúteo 2 ou 3 no ovário direito (CLD2-3) e um folículo no ovário esquerdo de 10 mm de diâmetro (FE10). A consistência normal do útero (é normal quando não há edema ou turgescência) é encontrado em vacas não prenhes durante o diestro, ou em vacas que estão em anestro. O CL 2 ou 3 é uma estrutura bem desenvolvida que deforma o ovário e em alguns casos representa mais de 50% da massa ovariana. Classificá-los como CL 2 ou 3 é uma apreciação subjetiva do tamanho do corpo lúteo e não tem significado prático, pois em qualquer dos casos o manejo é o mesmo. O CL indica que a vaca está em qualquer dia do diestro e, obviamente, indica que está ciclando. Durante o diestro pode-se encontrar folículos de tamanho diferente em qualquer um dos dois ovários, já que este depende das ondas de desenvolvimento folicular. É importante frisar que as estruturas mencionadas podem estar em ovários diferentes ou no mesmo ovário. O achado mais importante nesta fase é a presença do corpo lúteo o que permite o tratamento com a PGF2α, o que resulta na apresentação do estro nas próximas 48 a 120 horas. A presença de um corpo lúteo é o estado fisiológico que é mais frequentemente encontrado neste grupo de vacas, primeiro porque paradoxalmente a maior proporção de vacas em “anestro” está ciclando (anestro funcional) e, em segundo lugar, porque o diestro ocupa 65% dos dias do ciclo estral. 7.2 UE CLD1 FE10-15 Útero edematoso (UE) com um corpo lúteo 1 no ovário direito (CLD1) e um folículo 10 ou 15 mm de diâmetro no ovário esquerdo. O útero edematoso pode ser encontrado no proestro e metaestro. A presença do CL1 e um folículo grande indica que se trata de uma vaca que muito provavelmente é encontrado em proestro. A diferença entre um CL1 e um CL 2 ou 3 é basicamente o seu tamanho; um CL1 é uma estrutura pequena com consistência dura. As vacas que têm estas características devem ser marcadas para que os trabalhadores prestem mais atenção, já que apresentarão o estro nas próximas 48 a 72 horas. Se a vaca não apresentar estro nesse período, deverá ser palpada na semana seguinte. 7.3 UT DE FE10-15 Útero túrgido ou tonificado, ovário direito estático e ovário esquerdo com um folículo de 10 ou 15 mm de diâmetro. Estes achados, além da presença de muco estral, correspondem a uma vaca em estro. Frequentemente, na palpação das vacas do grupo de anestro, há vacas em estro; estas vacas deverão ser programadas para inseminação. 7.4 UE DE EE Útero estático e ovários estáticos. Estas observações correspondem a uma vaca em metaestro; esta decisão tem uma alta margem de erro uma vez que também pode corresponder a um animal no proestro ou em anestro verdadeiro. Um achado que permite ser mais bem sucedido no diagnóstico é a presença de sangue no muco cervical; neste caso, a presença de sangue indica, com certeza, que a vaca está em metaestro; no entanto, nem todas as vacas apresentam este sangramento. As vacas com estes achados devem ser palpadas sete dias depois para confirmar ou corrigir um primeiro diagnóstico. Se a primeira palpação foi correta, na segunda se encontrará um CL2-3. 7.5 UE CHD FE10 Útero edematoso, com corpo hemorrágico no ovário direito (CHD) e com folículo de 10 mm de diâmetro no ovário esquerdo. Estas observações são de uma vaca em metaestro. O corpo hemorrágico é considerado como a fase de transição entre o folículo e o corpo lúteo; o CH é palpado como uma estrutura com uma saliência em forma de papila e é muito suave ao toque. Será necessário esperar 4 ou 5 dias para que se converta num corpo lúteo maduro e assim destruí-lo com PGF2α. Na rotina, estas vacas são palpadas na seguinte revisão (sete dias depois). 7.6 UN DE EE Útero normal e ovários estáticos. Este caracteriza as vacas que estão no anestro verdadeiro. As vacas caem no anestro principalmente por se encontrar em balanço negativo de energia; este problema é mais grave em vacas de primeiro parto. O único tratamento eficaz consiste em melhorar o seu estado metabólico. Tratamentos hormonais não funcionam caso não seja resolvido primeiro o seu estado nutricional. 7.7 UN CFD EE Útero normal, cisto folicular no ovário direito e ovário esquerdo estático. Embora as vacas com cistos foliculares sejam caracterizadas por apresentar estros recorrentes, também chegam a apresentar anestro. O tratamento consiste na administração do GnRH ou hCG. 7.8 UN CLD EE Útero normal, cisto luteinizado no ovário direito e ovário esquerdo estático. Este cisto também é causado por uma deficiência na secreção de LH, só que neste caso a deficiência foi parcial, o que provoca um certo grau de luteinização. O cisto luteinizado é uma estrutura com mais de 20 mm de diâmetro de paredes grossas. O tratamento indicado é a administração de PGF2α. Na prática, é difícil diferenciar um cisto folicular de um luteinizado, pelo que o tratamento recomendado é, primeiro, a administração de GnRH ou hCG e sete dias depois é injetado PGF2α (figura 7). 7.9 Piometra CLD2-3 FE A piometra é uma condição que ocorre principalmente nos primeiros 30 dias pós-parto; no entanto, na revisão das vacas anéstricas são encontradas vacas com esta patologia. O tratamento indicado consiste na administração de PGF2α. 8. Tratamentos hormonais para indução da atividade ovariana O estabelecimento precoce da ciclicidade pós-parto favorece a involução uterina e está positivamente correlacionado com a fertilidade; ou seja, quanto mais ciclos estrais a vaca tenha antes da primeira inseminação, a percentagem de concepção é maior. Um tratamento utilizado para induzir a primeira ovulação pós-parto em vacas anéstricas, consiste na administração de GnRH quando à palpação retal se encontra um folículo grande (> 10 mm). Com isso se pretende fazer o folículo ovular e depois injeta-se PGF2α para provocar a regressão lútea. Outras combinações consistem na administração de GnRH e na inserção de dispositivos de liberação de progesterona e, ao retirar o progestágeno, injeta-se PGF2α (figura 8). No entanto, os tratamentos mencionados são de uso comum, não funcionam em todos os casos. Um requisito para se obter êxito é que as vacas devem ter boa condição corporal ou que estejam ganhando condição corporal. Embora os tratamentos hormonais possam ajudar em alguns casos, não deve-se esquecer que as causas do anestro não são corrigidos apenas com a administração de hormônios, já que a vaca não cicla porque toda a informação do estado metabólico que recebe o cérebro, indica que não o deve fazer. 9. Gonadotropina coriônica equina (eCG) Na égua, por volta do dia 30 de gestação, células do córion migram para o endométrio e formam umas estruturas conhecidas como copas endometriais. Entre o dia 40 e o dia 130 de gestação nestas estruturas é produzido o eCG (anteriormente conhecida como gonadotropina sérica da égua prenha ou PMSG, pela sua abreviatura em inglês). Na égua esse hormônio tem atividade de LH pelo qual estimula a função do corpo lúteo e promove a formação de corpos lúteos acessórios. Nos ruminantes, o eCG se une aos receptores de LH e FSH do folículo, estimulando o desenvolvimento folicular, e no corpo lúteo estimula a secreção de progesterona. O eCG tem sido utilizado com a finalidade de superovulação e em vacas de corte sob anestro é incluído em programas com progestágenos para induzir ciclicidade. Nestes programas é injetado eCG no momento da remoção do progestágeno, o que favorece o desenvolvimento folicular e apresentação do estro. Em rebanhos leiteiros na Nova Zelândia tem sido incrementado a taxa de prenhez sem aumentar a proporção de partos gêmeos, através da injeção de eCG na remoção do dispositivo de libertação de progesterona em programas combinados com a injeção de benzoato de estradiol. RESUMO ➢ Transcorrem 15 dias pós-parto para que a hipófase responda ao hormônio GnRH. ➢ Entre os dias 12 e 15 pós-parto começa-se a secreção de FSH e iniciam as ondas foliculares. ➢ As vacas chegam ao ponto mais baixo de BEN entre os dias 15 e 20 pós-parto. ➢ As vacas iniciam a atividade ovariana normal, em média, após os 40 dias pós-parto. ➢ Aos 70 dias pós-parto é normal que 20% das vacas ainda estejam em anestro. ➢ Na primeira ovulação pós-parto 25% das vacas desenvolvem corpos lúteos de vida curta e 30% mostram corpos lúteos de vida longa (persistentes). ➢ As anormalidades do aparelho reprodutor são responsáveis por 10% das causas de anestro. ➢ 5 a 30% das vacas desenvolvem cistos foliculares nos primeiros 60 dias pós-parto e 60% destas se recuperam de forma espontânea. ➢ No dia 30 pós-inseminação é possível identificar vacas vazias mediante a ecografia e reservá-las para a ressincronização. ➢ A proteína B específica da gestação aparece no soro a partir do 15º dia de gestação. ➢ Para o diagnóstico precoce de gestação é recomendado medir a PSPB no dia 30 pósinseminação e em vacas com mais de 90 dias pós-parto. ➢ Entre os dias 50 e 60 pós-parto todas as vacas não servidas devem ser examinadas via retal para programar seu serviço. REFERÊNCIAS BIBLIOGRÁFICAS AMBROSE, Divakar J. Postpartum anestrus and its management in dairy cattle. Bovine Reproduction, p. 408-430, 2021. BALL, P. J. H.; PETERS, A. R. Reprodução em bovinos. São Paulo: SP, 2006. Características Gerais dos Bovinos/General Characteristics of Cattle Bovine. 2020. Fisiologia da Reprodução Animal: Ovulação, Controle e Sincronização do Cio. 2020. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. DERIVAUX, Jules; BECKERS, Jean-François; ECTORS, Francis. L'anoestrus du postpartum. Vlaams Diergeneeskundig Tijdschrift, v. 53, p. 215-229, 1984. ELLI, Massimiliano. Manual de reproducción en ganado vacuno. Zaragoza, ES: Servet Edit., 2005. FERNÁNDEZ DE CÓRDOBA DE LA BARRERA, Luis. Reproducción aplicada en el ganado bovino lechero. 1993. FERREIRA, A. de M. Reprodução da fêmea bovina: fisiologia aplicada e problemas mais comuns (causas e tratamentos). Juiz de Fora: Minas Gerais–Brasil, p. 422, 2010. GARVERICK, H. Allen. Ovarian follicular cysts in dairy cows. Journal of dairy science, v. 80, n. 5, p. 995-1004, 1997. HAFEZ, Elsayed Saad Eldin; HAFEZ, Bahaa. Reprodução animal. 2004. HIDALGO, Galina et al. Reproducción de animales domésticos. 2008. PETER, A. T.; VOS, P. L. A. M.; AMBROSE, D. J. Postpartum anestrus in dairy cattle. Theriogenology, v. 71, n. 9, p. 1333-1342, 2009. PETERS, A. R. et al. Reproducción del ganado vacuno. 1991. SPAIN, JAMES N.; LUCY, MATTHEW C.; HARDIN, DAVID K. Effects of nutrition on reproduction in dairy cattle. In: Current Therapy in Large Animal Theriogenology. WB Saunders, 2007. p. 442-450. UNGERFELD, Rodolfo. Reproducción de los animales domésticos. Edizioni LSWR, 2020. VILLA-GODOY, A. et al. Association between energy balance and luteal function in lactating dairy cows. Journal of Dairy Science, v. 71, n. 4, p. 1063-1072, 1988. WATHES, D. C. et al. Influence of negative energy balance on cyclicity and fertility in the high producing dairy cow. Theriogenology, v. 68, p. S232-S241, 2007. (shrink)

John Ellis McTaggart defended an idealistic view of time in the tradition of Hegel and Bradley. His famous paper makes two independent claims (McTaggart1908): First, time is a complex conception with two different logical roots. Second, time is unreal. To reject the second claim seems to commit to the first one, i.e., to a pluralistic account of time. We compare McTaggarts views to the most important concepts of time investigated in physics, neurobiology, and philosophical phenomenology. They indicate that a (...) unique, reductionist account of time is far from being plausible, even though too many conceptions of time may seem unsatisfactory from an ontological point of view. (shrink)

The aim of my paper is to describe and evaluate different conceptions of holism in Ludwig Wittgenstein’s Tractatus Logico-Philosophicus. I distinguish three readings of holistic elements in this work: i) Minimal Holism (E. Anscombe, M. Black, D. Pears); ii) Moderate Holism (J. Conant, C. Diamond, G. Ryle); and iii) Radical Holism (G. Bar-Elli, M. Kremer, P. Livingston). The conclusion is that the most viable option is Moderate Holism since it embraces the logico-syntactical notion of use, rejects an anachronistic interpretation of (...) Tractatarian ontology and allows us to see that the holistic elements are complementary to the initial atomism of the work. Moreover, I point to the consequences of the topic for the overall reading of Wittgenstein’s early and late work. (shrink)

1 Introduction1 In the 1980s, hermeneutics was often incorporated into deconstructionism and literary theory. Rather than focus on authorial intentions, the nature of writing itself including codes used to construct meaning, socio-economic contexts and inequalities of power,2 Gadamer introduced a different perspective; the interplay between effects of history on a reader’s understanding and the tradition(s) handed down in writing. This interplay in which a reader’s prejudices are called into question and modified by the text in a fusion of understanding and (...) topic revitalized the study of the printed word. Gadamer’s turn to language for understanding the meaning of Being also appealed to the post-modern antipathy toward modernity and metaphysics.3 If the truth and validity of interpretations are limited to communities of language, then our mode of being in history cannot but be historical. This point of view rendered Gadamer’s phenomenological hermeneutics vulnerable to the critique of moral and epistemological relativism. However, Gadamer’s theory of interpretation also stems from re-examination of the beginning of knowledge in the Pre-Socratics and Plato, and on this basis, is receptive to another dimension of inquiry than that which was trending in North America. -/- At the East-West Center, University of Hawai’i at Manoa in 1982, Chung-ying Cheng for the first time introduced onto-hermeneutics to an audience of esteemed philosophers including Li Zehou, Ren Jiyu, Feng Youlan, and Zhang Liwen.4 In contrast to schools of deconstruction and literary theory that had disengaged the interpreter from trans-historical sources of meaning and truth, Cheng explained that interpreters exist within a cosmological order inextricable from responsibility to harmonize Heaven and Earth in creative acts of interpretation. By integrating Chinese cosmology into hermeneutics through ontology, he tacitly challenged philosophers in the West to re-examine assumptions about humanity’s place in nature and by implication, Gadamer’s recovery of the beginnings of knowledge in Western philosophy. -/- Cheng’s Neo-Confucianism is inspired by the method and goals of Thomé H. Fang. The following words by Fang seem to prefigure, although in an indistinct and bundled way, aspects of Cheng’s philosophy including a Mencian theory of human nature, comprehensive observation, and creativity: “In the very process of living in concord with creative Nature, Man is charged with an ideal to be fully realized in the light of the principle of comprehensive harmony.”5 Like Fang, Cheng reinvigorates Chinese culture and language, but not solely in order to vindicate the insights of Neo-Confucianism. He has studied Western thought, from pragmatism and the analytic school to German idealism and phenomenology, to unlock and clarify philosophical concepts within the Yijing tradition and thereby render them intelligible to Anglophones. The result has been an awakening of Western scholars to the moral and cultural consequences of decoupling their thought from metaphysical foundations that are neither dogmatic nor doctrinal. -/- Not unlike the dialectic of Gadamer’s dialogue form, onto-generative hermeneutics integrates contrary positions on the same topic in order to blend both sides into a world philosophy, or as Cheng says, a “totalizing or integrative theory,”6 not to be confused with a theoretical rewording of a theory. On the contrary, the universal scope and relevance of hermeneutics stems from personal experience. Just as Gadamer, in response to faction and strife, immersed himself in Plato during the war years, and developed a method with which to harmonize opposites, so too, according to On-cho Ng, was Cheng moved by faction, strife and political persecution to develop a path toward unity.7 Gadamer taught at McMaster University in Hamilton, Ontario, and Cheng at the University of Hawai’i at Manoa among other institutions in North America. They facilitated trans-continental educational and cultural ties. Similar experiences yield similar insights irrespective of differences of time and place. Hence, authors in this issue who reside in Europe, China and North America, delineate the differences between Gadamer and Cheng, yet also, in light of Cheng’s onto-generative method and cosmology, develop integrative theories. Due to the page-budget restriction of the publisher, certain articles of this special theme will be subsequently published in the next issue. -/- 2 Integrative Theory This special issue of The Journal of Chinese Philosophy confirms a dimension of hermeneutics that Cheng has both motivated and inspired. The contributors do not abide by the conviction that since thought is mediated by language, interpretations cannot transcend culture. On the contrary, their research exemplifies the fruits of trans-historical onto-dialogical hermeneutics within limits defined by their field inquiry, organized into Parts I and II, around three themes: language, the philosophy of history and ethics. -/- Andrew Fuyarchuk introduces the theme of ontology in relation to Gadamer’s turn to language. Fuyarchuk argues that Chung-ying Cheng’s criticism of Gadamer’s hermeneutics is informed by Heidegger’s concept of Dasein and thereby overlooks how Gadamer’s Platonic-Pythagorean problem of the division between the One and Many is harmonized in the event of language, which in turn positions Gadamer in proximity to the presupposed grounds of receptivity in Cheng’s onto-generative hermeneutics. Lauren Pfister’s contributing article addresses the year 2000 meeting between Cheng and Gadamer in Heidelberg and expands the transhistorical grounds of meaning in Gadamer to matters of theology. Pfister’s summary of the written Chinese record of their conversation indicates that Cheng does not address the role of Christian philosophy and hence, the role of the inner word in Gadamer’s hermeneutics. This is important not only for detecting changes in Cheng’s philosophical development, but also for modifying his hermeneutics along the lines of a living conversation, possibilities explored by Pfister in a sequel to the article submitted to this issue. Nevertheless, by raising the issue of how Gadamer’s turn to language for understanding the meaning of Being extends possibilities in Cheng’s thought, Pfister anticipates the article by Katarina Gajdosova. She returns to the roots of Chinese thought during the Warring States period and broadens the meaning of names in recently excavated texts. Contrary to the conventions about how to understand terms, she appeals to both Heidegger’s ontology and Cheng’s notion of receptivity and creativity to reinterpret naming in relation to cosmology. Along the same lines, insofar as the event of Being is lingual, Jay Goulding captures its emergent structure in an evolving community of scholars and scholarship. He recalls his philosophical journey toward Cheng’s philosophy that begins in conversations with Gadamer at McMaster University in Hamilton, leads to Heidegger and Asian thought, expands into turning points with teachers and colleagues from various backgrounds that by increments contributed to Goulding’s formulation of “Daoist phenomenology.” -/- Although differing traditions guide their inquiries and research, Cheng and Gadamer recall the wisdom of the past to ameliorate the fragmentation in contemporary life. This leads them to re-examine the origins of philosophy; historical roots and thus sources of creative re-interpretations East and West whose affinities are developed in contributions by Hyun Höchsmann and Friederike Assandri. Höchsmann assesses convergences and divergences in the origins of Chinese and Western philosophy (Confucius and Socrates, the Yijing and Pre-Socratics) that culminates in pairing Gadamer’s understanding of paideia in the context of Plato’s political cosmology in the Timaeus with moral and social cultivation in The Western Inscription. She delineates the limits of this comparison which in turn justifies introducing Vattimo’s notion of locality. Assandri’s comparative analysis moves between India and China, Buddhism and Tang Daoism. Based on Gadamer’s argument that writing detaches concepts from their cultural moorings, she defines and applies three levels of understanding in onto-generative hermeneutics to Buddhist terms that were assimilated into the Benji Jing and in so doing clarifies essential dimensions of Daoism. -/- Contributions by Stephen Palmquist and Nicholas Brasovan position Cheng in relation to Kant and Gadamer by way of Aristotle’s ethics respectively. On the one hand, Palmquist plots Cheng’s evolving criticism of Kant’s moral philosophy and draws on crucial dimensions of Gadamer’s hermeneutics to reposition that criticism in a constructive relation to Kant’s emphasis on the philosophical conditions of morality while also indicating how religious dimensions of his thought answer Cheng’s concerns for lived moral action. For Palmquist, Gadamer enables a constructive criticism of Cheng. On the other hand, Brasovan compares Cheng’s Yijing-based account of moral deliberation with Gadamer’s Aristotelian-based ethics and reasons that in contrast to Cheng, Gadamer’s hermeneutical consciousness is disengaged from practical knowledge. For Brasovan, Cheng is a constructive critic of Gadamer. Palmquist and Brasovan’s divergent angles on Gadamer and Cheng map onto a dialectic of contrast and complementarity that constitutes the inner logic of Cheng’s philosophy. In other words, Gadamer and Cheng ought to be read alongside one another for the sake of removing discrepancies and contradictions, which constitutes the organic structure of their thinking. -/- 3 Our Mode of Being in History Is Not Historical The conversations between Cheng and Gadamer in this issue of The Journal of Chinese Philosophy pivot on language, philosophy of history and ethics within a comparative framework of analysis, but also explore the grounds that make the comparisons possible. Those grounds are informed by Chinese cosmology, and function to wrest Gadamer from the shadow of Heideggerian facticity and reposition him within the range of Cheng’s ideas about our place in nature that is embedded in his question about how mind emerges from inorganic matter.8 -/- For Gadamer scholars of Heidegger, human finitude, our ownmost individuating death ensures that hermeneutics is always open to the other as other, always on the way toward understanding the meaning of Being. To arrest the process in a concept of “the Absolute” cannot but represent someone’s point of view, and thereby render hermeneutics indistinguishable from ideology. However, insofar as finitude is defined by them in terms of an onto-theological concept of immorality, finitude is a metaphysical concept consistent with epistemologies and confuse beings with the meaning of Being. As a result, the celebrated political value of hermeneutics to always be on the way toward an understanding of the meaning of Being admits subtle variations on the same worldview that are insufficiently self-critical. -/- Gadamer scholars of Heidegger are right. A transformation in ethos and opening to the meaning of Being depends on awareness of finitude. Yet this awareness does not yield openness to more of the same, i.e., discourse structurally incapable of coming to unity but instead, for both Gadamer and Cheng, openness to a distinctly different ontological dimension of reality. As Sandra Wawrytko and So-Seong Park indicate,9 this ontological dimension is prefigured in the experience of being-as-a-whole or the totality of all possible relations in both Chinese totemic shamanistic rituals,10 and Greek Dionysian festivals.11 Through these religious experiences human ethos and therefore consciousness is expanded and elevated from being centered on one’s ownmost concerns toward an affinity with all sentient beings from insects and plants to animals. The channel for this affinity is an auditory disposition and hence, the emotions, compassion, and feeling response. -/- The capacity for an auditory disposition, or as Gadamer calls it, listening consciousness to respond to the inter-relationality and therefore inherent balance of nature is developed through music, song and dance of the religious rituals and festivals. They facilitate the unity of mind with nature. This use of music, that transforms ordinary consciousness, explains Cheng’s emphasis on the receptivity of feeling response in comprehensive observation, and Gadamer’s emphasis on openness to the other in attunement. However, an auditory disposition characteristic of pre-literate oral cultures that reveals the “All” need not rely on religion. As theorists about the evolution of language have explained,12 modern languages preserve their pre-historical past in music or prosody. That is to say, the song and dance that revealed the totality of inter-related beings to an ethos of comprehensive observation and attunement toward beings in classical civilizations is retained in the back-and-forth movement or rhythm of the dialogue form. Our mode of being in history is a mode of being in nature – through the music of language. -/- While alerting the reader to the limits of a nominalist interpretation, Gadamer expresses the inner law of the nature as follows: “in perishing there is always becoming, and in becoming there is always perishing.”13 Considered in process, opposites generate and blend into each other. This law of nature applies to everything.14 Hence, in a manner comparable to Pfister’s concluding insights, onto-dialogical hermeneutics is not only open to discrete events of otherness but moreover, to the moving structure of reality expressed, as Gajdosova suggests, in the existential moment of naming. Considered as interplay of tension and resolution with a life of its own, the dialectic of a dialogue is self-similar to the way in which an organism grows (by instinct). There is, therefore, a sense in which the art of interpretation extends the human mind into the eternal cycles of nature such that we participate in the articulation of the inner telos/homeostasis toward which all beings strive and importantly for Gadamer scholars of Heidegger, within the material limits of energy to which our embodied minds are self-evidently subject. In mortality there is always immortality. (shrink)

John Turri gives an example that he thinks refutes what he takes to be “G. E. Moore's view” that omissive assertions such as “It is raining but I do not believe that it is raining” are “inherently ‘absurd'”. This is that of Ellie, an eliminativist who makes such assertions. Turri thinks that these are perfectly reasonable and not even absurd. Nor does she seem irrational if the sincerity of her assertion requires her to believe its content. A commissive counterpart of (...) Ellie is Di, a dialetheist who asserts or believes that The Russell set includes itself but I believe that it is not the case that the Russell set includes itself. Since any adequate explanation of Moore's paradox must handle commissive assertions and beliefs as well as omissive ones, it must deal with Di as well as engage Ellie. I give such an explanation. I argue that neither Ellie's assertion nor her belief is irrational yet both are absurd. Likewise neither Di's assertion nor her belief is irrational yet in contrast neither is absurd. I conclude that not all Moore-paradoxical assertions or beliefs are irrational and that the syntax of Moore's examples is not sufficient for the absurdity found in them. (shrink)

In recent years, feminist scholarship on emotional labor has proliferated. I identify a related but distinct form of care labor, hermeneutic labor. Hermeneutic labor is the burdensome activity of: understanding and coherently expressing one’s own feelings, desires, intentions, and movitations; discerning those of others; and inventing solutions for relational issues arising from interpersonal tensions. I argue that hermeneutic labor disproportionately falls on women’s shoulders in heteropatriachal societies, especially in intimate relationships between women and men. I also suggest that some of (...) the gendered burdens of emotional labor that feminist scholars point out would better be described as hermeneutic labor. Drawing on feminist philosophy as well as findings from social psychology and sociology, I argue that the exploitation of women’s hermeneutic labor is a pervasive element of what Sandra Bartky calls the ‘micropolitics’ of intimate relationships. The widespread expectation that women are relationship maintenance experts, as well as the prevalence of a gendered demand-withdraw pattern of communication, leads an exploitative situation to appear natural or even desirable, even as it leads to women’s dissatisfaction. This situation may be considered misogynistic in Kate Manne’s sense, where misogyny is a property of social environments rather than a worldview. (shrink)

The role of emotions in mental life is the subject of longstanding controversy, spanning the history of ethics, moral psychology, and educational theory. This paper defends an account of love’s cognitive power. My starting point is Plato’s dialogue, the Symposium, in which we find the surprising claim that love aims at engendering moral virtue. I argue that this understanding affords love a crucial place in educational curricula, as engaging the emotions can motivate both cognitive achievement and moral development. I first (...) outline the state of the challenge between dominant rival theories regarding emotions in learning. Next, I demonstrate how Platonic virtue ethics offers the most tenable prospect for an education of reason and emotion. Third, I sketch three practical ways educators might constructively engage emotions in the classroom. I conclude that love’s virtue is its peerless power to motivate the creative and lateral thinking which leads to moral development. (shrink)

Causal selection has to do with the distinction we make between background conditions and “the” true cause or causes of some outcome of interest. A longstanding consensus in philosophy views causal selection as lacking any objective rationale and as guided, instead, by arbitrary, pragmatic, and non-scientific considerations. I argue against this position in the context of causal selection for disease traits. In this domain, causes are selected on the basis of the type of causal control they exhibit over a disease (...) of interest. My analysis clarifies the principled rationale that guides this selection and how it involves both pragmatic and objective considerations, which have been overlooked in the extant literature. (shrink)

In recent decades, interest in non-monogamous intimate relationships has grown rapidly. Polyamory, relationship anarchy, consensual or ethical non-monogamy, and more have become popular in academic and public discourse. These practices destabilize the privileging of heterosexual nuclear families and the assumption that romantic coupledom is the ultimate form of love. Non-monogamous approaches flout cultural norms of exclusivity by avowing that intimacy is compatible with multiple dyadic and/or multi-party relationships. This article explores Simone de Beauvoir's theory and practice of non-monogamy in her (...) theoretical writings and diaries. (shrink)

This paper has two aims: First, to provide an elucidation of the kind of meta-ethical programme at work in Mary Midgley's (1919-2018) Beast and Man: The Roots of Human Nature (published in 1978). Second, to make the case for Midgley's placement within the philosophical and philosophical-historical canon, specifically, as an important figure within the meta-ethical movement of ‘Neo-Aristotelian naturalism'. On historical and systematic grounds, I argue that Midgley should be classified as a neo-Aristotelian ethical naturalist notwithstanding the distinctive features of (...) Midgley’s specific brand of neo-Aristotelianism. In doing so, I suggest a more generally applicable family resemblance approach to the history of philosophy in order to classify and re-introduce into the canon figures in the history of philosophy that are in danger of falling into oblivion. (shrink)

Kant holds that the whole “higher faculty of knowledge” (‘reason’ or ‘understanding’ in a broad sense), is a spontaneous faculty. But what could this mean? It seems that it could either be a perfectly innocent claim or a very dangerous one. The innocent thought is that reason is spontaneous because it is not wholly passive, not just a slave to what bombards the senses. If so, then the rejection of Hume’s radical empiricism would suffice for Kant’s claim. But the dangerous (...) thought is that reason, and the ‘I think’ which expresses it, is free, having the power to produce something entirely from itself. While this freedom is characteristic of practical reason, could it be characteristic of reason in general, even in its theoretical employment? Some contemporary interpreters have admirably defended the ‘dangerous’ conception by stripping it of the implication that it makes reason in general entirely self-sufficient. I attempt to add to this effort. However, what I contend is that this weightier conception of spontaneity (‘absolute’ or ‘non-relative’ spontaneity) requires abandoning a certain approach to the question that has been assumed by virtually everyone in the debate—namely, that the question can be answered by siding with either the so-called ‘metaphysical’ or the ‘epistemic’ interpreters of Kant. My goal is to suggest that the proper perspective on reason’s spontaneity resists such characterizations all together, and thereby resists any of the conditions under which it could be understood as ‘relative’ to anything. (shrink)

The article tries to show that what is often called 'Moderate Deontology' is incoherent.

The context for biological emergence is modular hierarchical structures; their existence is what enables functional complexity to arise. Because of the openness of organisms to their environment, complete initial data (position, momentum) of all particles making up their structure is insufficient to determine future outcomes, because unpredictable new matter, energy, and information impacts each organism from the exterior. Consequently, through Darwinian evolution, life has developed processes to handle this issue functionally on short time scales as well on longer developmental timescales. (...) Symbolism and technology are the transforming factors handling this issue at the social levels, which is where the most sophisticated outcomes of openness occur. Considering the cosmological context, the issue is, should the universe itself be regarded as an open system over time? I make the case that is indeed so, because radically new outcomes occur such as the existence of aircraft, iPads, and the internet, which could not plausibly have been encoded in some form of data on the Last Scattering Surface in the expanding universe. (shrink)

The purpose of this paper is to offer a defense of the emergentist view concerning emergent brute facts. To this end, I review and evaluate the three main objections raised against the possibility of emergent brute facts; the simplicity argument, the question of whether the idea of emergent brute facts is a coherent idea and the question of empirical evidence. My contention is that none of these arguments is successful in refuting the possibility or the plausibility of the existence of (...) emergent brute facts. I also argue that, in the end, the question revolves around empirical evidence, and that empirical considerations favour the existence of emergent brute facts. (shrink)

Recent philosophical work on causation has focused on distinctions across types of causal relationships. This paper argues for another distinction that has yet to receive attention in this work. This distinction has to do with whether causal relationships have “material continuity,” which refers to the reliable movement of material from cause to effect. This paper provides an analysis of material continuity and argues that causal relationships with this feature are associated with a unique explanatory perspective, are studied with distinct causal (...) investigative methods, and provide different types of causal control over their effects. (shrink)

ENGLISH ABSTRACT: This thesis is a philosophical exposition of violence informed by two theoretical positions which confront complexity as a phenomenon. These positions are complexity theory and deconstruction. Both develop systemsbased understandings of complex phenomena in which relations of difference are constitutive of the meaning of those phenomena. There has been no focused investigation of the implications of complexity for the conceptualisation of violence thus far. In response to this theoretical gap, this thesis begins by distinguishing complexity theory as a (...) general, trans-disciplinary field of study from critical complexity theory. The latter is used to develop a critique and criticism of epistemological foundationalism, emphasising the limits to knowledge and the normative and ethical dimension of knowledge and understanding. The epistemological break implied by this critique reiterates the epistemological shift permeating the work of, among others, Friedrich Nietzsche and Jacques Derrida. In this context, critical complexity theory begins to articulate the idea of violence on two levels: first, as an empirical, ethical problem in the system; and, secondly, as asymmetry and antagonism. Violence in this second sense is implicated in the dynamic relations of difference through which structure and meaning are generated in complex organisation. The sensitivity to difference and violence shared by critical complexity theory and deconstruction allows for the parallel reading of these philosophical perspectives; and for the supplementation and opening of critical complexity theory by deconstruction within the architecture of this thesis. This supplementation seeks to preserve the singularity of each perspective, while exploring the potential of their points of affinity and tension in the production of a coherent philosophical analysis of violence. Deconstruction offers a more developed understanding of violence and a wealth of related motifs: différance, framing, law, singularity, aesthetics and others. These motifs necessitate the inclusion of other philosophical voices, notably, that of Nietzsche, Arendt, Kant, Levinas, and Benjamin. In conversation with these authors, this thesis links violence to meaning, to its possibility, to its production and to the process by which meaning comes to change. Given these links, violence is conceptualised in relation to the notion of difference on three distinct levels. The first is the difference between elements in a complex system of meaning; the second is the notion of difference between systems or texts around which boundaries or frames can be drawn; and the third is the notion of difference between meaning and the absence of meaning. This discussion examines the relationship between this violence implicated in the constitution of meaning and the more colloquial understanding of violence as atrocity, as rape, murder and other socially, politically and ethically problematic expressions thereof. It is to empirical violence, following Derrida and Levinas, that we are called to respond and to intervene in the suffering of the other. The ethical and political necessity of response anchors this discussion of violence. And, it is towards the possibility of an adequate response – the possibility of an ethics sensitive to its own violence and a politics that is directed at the eradication of empirical violence – which this discussion navigates. (shrink)

In ‘Affectivity in Heidegger I: Moods and Emotions in Being and Time’, we explicated the crucial role that Martin Heidegger assigns to our capacity to affectively find ourselves in the world. There, our discussion was restricted to Division I of Being and Time. Specifically, we discussed how Befindlichkeit as a basic existential and moods as the ontic counterparts of Befindlichkeit make circumspective engagement with the world possible. Indeed, according to Heidegger, it is primarily through moods that the world is ‘opened (...) up’ and revealed to us as a world that is suffused with values and entities that already matter to us. In this companion essay, our aim is to expand our analysis of affectivity in the following ways: first, we revisit our discussion of Befindlichkeit in light of Heidegger's discussion of temporality in Division II of BT; second, we discuss the basic or fundamental mood of boredom and its ontological significance; we conclude by providing a brief characterization of how Heidegger's notion of mood changes in his later thinking. (shrink)

Two decades ago, in 1994, in the context of the 4th EU Framework Programme, ELSA was introduced as a label for developing and funding research into the ethical, legal and social aspects of emerging sciences and technologies. Currently, particularly in the context of EU funding initiatives such as Horizon2020, a new label has been forged, namely Responsible Research and Innovation. What is implied in this metonymy, this semantic shift? What is so new about RRI in comparison to ELSA? First of (...) all, for both labels, the signifier was introduced in a top-down manner, well before the concept that was signified by it had acquired a clear and stable profile. In other words, the signifier preceded the research strategies actually covered by these labels. Moreover, the newness of RRI does not reside in its interactive and anticipatory orientation, as is suggested by authors who introduced the term, but rather in its emphases on social-economic impacts. (shrink)

In the words of Iris Murdoch, Mary Midgley’s Beast and Man built “an urgently needed bridge between science and philosophy”.1 While science and philosophy have never been entirely remote, Murdoch was right to observe the achievement of her friend, Midgley, in drawing a new and insightful connection between these disciplines. A bridge, more specifically, between scientific investigations into human and animal behaviour, and philosophical enquiries into the concept of human nature. A moral philosopher by trade, Midgley imbues the neo-Aristotelian understanding (...) of man as a ‘rational animal’ with the many traits (she argues) we share with our diverse earthly neighbours – nonhuman animals. (shrink)

A recent wave of scholarship has challenged the traditional way of understanding of self-command in Adam Smith’s Theory of Moral Sentiments as ‘Stoic’ self-command. But the two most thorough alternative interpretations maintain a strong connection between self-command and rationalism, and thus apparently stand opposed to Smith’s overt allegiance to sentimentalism. In this paper I argue that we can and should interpret self-command in the context of Smith’s larger sentimentalist framework, and that when we do, we can see that self-command is (...) ‘sentimentalized’. I offer an interpretation of Smithian self-command, arguing that self-command has its motivational basis in the natural desire for the pleasure of mutual sympathy; that self-command is guided by the sentimental standard of propriety; and that self-command works through the psychological mechanism of the ‘supposed’ impartial spectator. And I show that Smithian self-command is a home-grown, sentimentalist virtue and not an awkward rationalistic transplant. (shrink)

Social scientists appeal to various “structures” in their explanations including public policies, economic systems, and social hierarchies. Significant debate surrounds the explanatory relevance of these factors for various outcomes such as health, behavioral, and economic patterns. This paper provides a causal account of social structural explanation that is motivated by Haslanger (2016). This account suggests that social structure can be explanatory in virtue of operating as a causal constraint, which is a causal factor with unique characteristics. A novel causal framework (...) is provided for understanding these explanations–this framework addresses puzzles regarding the mysterious causal influence of social structure, how to understand its relation to individual choice, and what makes it the main explanatory (and causally responsible) factor for various outcomes. (shrink)

An entry on the meaning and history of emergence as well as the current debate on emergentism in philosophy and the sciences.

According to mainstream philosophical views causal explanation in biology and neuroscience is mechanistic. As the term ‘mechanism’ gets regular use in these fields it is unsurprising that philosophers consider it important to scientific explanation. What is surprising is that they consider it the only causal term of importance. This paper provides an analysis of a new causal concept—it examines the cascade concept in science and the causal structure it refers to. I argue that this concept is importantly different from the (...) notion of mechanism and that this difference matters for our understanding of causation and explanation in science. (shrink)

Phenomenology's central insight is that affectivity is not an inconsequential or contingent characteristic of human existence. Emotions, moods, sentiments, and feelings are not accidents of human existence. They do not happen to happen to us. Rather, we exist the way we do because of and through our affective experiences. Phenomenology thus acknowledges the centrality and ubiquity of affectivity by noting the multitude of ways in which our existence is permeated by our various affective experiences. Yet, it also insists that such (...) experiences are both revealing and constitutive of human nature. It is precisely this last point that marks an important distinction between a phenomenological study of affectivity and perhaps all others. For phenomenology, one cannot understand the nature of human existence without coming to terms with the character of affectivity and at the same time, one cannot come to terms with the character of affectivity without understanding the nature of human existence. Practical and social engagements, scientific endeavors, familial and political interactions are all predicted on the fact that we are beings who are capable of being affectively attuned to ourselves, to the world, and to others. In this entry, we discuss Martin Heidegger's and Jean-Paul Sartre's respective accounts of affectivity. In the first section, we present Heidegger's understanding of affective existence. In this context, we discuss the significance of moods and offer an analysis of the affective phenomena of fear, anxiety, and boredom. In the second section, we present an overview of Sartre's account of emotions and advance a Sartrean interpretation of fear and boredom. We conclude by raising some brief concerns with both accounts. (shrink)

This article interprets Teresa Brennan’s work on the forgetting of affect transmission in conjunction with Sylvia Wynter’s argument concerning the rise of Western Man through the dehumanization of native and African peoples. While not directly in dialogue, Wynter’s decolonial reading of Foucault’s epistemic ruptures enriches Brennan’s inquiry into this “forgetting,” given that callous, repeated acts of cruelty characteristic of Western imperialism and slavery required a denial of the capacity to sense suffering in others perceived as differently human. Supplementing Brennan with (...) Wynter, we can better describe the limits of sympathy discourses as resting on identification and perceived sameness. In turn, Brennan comes to Wynter’s defense in her call for a new science of plural cultures to redefine the human, which some have interpreted as a positivist misreading of Frantz Fanon. Brennan and Wynter alike have been criticized for their appeals to science; yet, I defend their respective proposals for social-scientific inquiry with support from Brennan’s response to the 1996 Sokal Hoax: the influence of the social on the biological body is, indeed, difficult to study, but this does not invalidate the inquiry as such. (shrink)

Social contract thought has always contained multiple and mutually conflicting lines of argument; the minimalist contractarianism so influential today represents the weaker of two main constellations of claims. I make the case for a Kantian contract theory that emphasizes the bedrock principle of consent of the governed instead of the mere heuristic device of the exit from the state of nature. Such a shift in emphasis resolves two classic difficulties: tradi- tional contract theory’s ahistorical presumption of a pre-political settlement, and (...) its impossibly high demands on citizens seeking to practice self-rule. Kant’s solutions to these problems of property rights and citizenship are found in his political works, rather than the ethical works through which Kant’s political theory is usually interpreted. (shrink)

Teresa Brennan was born in 1952 in Australia and died in South Florida, following a hit-and-run car accident in December 2002. In the ten years between her doctorate and her death, Brennan published five monographs, the most famous posthumously. The Transmission of Affect begins with a question that readers often remember: “Is there anyone who has not, at least once, walked into a room and ‘felt the atmosphere’?” Here and throughout her work, Brennan challenges the self-contained subject of Western modernity, (...) whose affects are presumed to be possessions of that self, underscoring the historical emergence of this egoic construction.I never met Teresa Brennan; I did not know her name until a decade after she... (shrink)

Sebastian Rödl’s 2018 book articulates and unfolds the thought that judgment’s self-consciousness is identical with its objectivity. This view is laid forth in a Hegelian spirit, against the spirit of Kant’s merely formal or transcendental idealism. I review Rödl’s central theses and then offer a criticism of his reading of Kant. I hold that we can agree with Rödl that self-consciousness is identical with objectivity (though only in a ‘formal’ sense). We can also agree with Rödl that this identity enables (...) us to see the completeness and the incompleteness of judgment as two sides of one coin. And, it is not necessary to reject the formality or ‘emptiness’ of Kant’s ‘I think’ in order to establish these points. Indeed, the virtues of these theses flows directly from such notions in Kant. And, because Rödl need not reject the central features of Kant’s formal idealism, he also need not locate them as the source of the need for a turn to Hegel. (shrink)

I argue that, for Kant, there is a point at which the notions of self-consciousness and self-limitation become one. I proceed by spelling out a logical progression of forms of self-consciousness in Kant’s philosophy, where at each stage we locate the limits of the capacity in question and ask what it takes to know those limits. After briefly sketching a notion of self-consciousness available even to the animal, we look at whether there could be a notion of self-consciousness available to (...) the capacity of human sensibility. At this stage I argue that Kant and Heidegger (or Heidegger’s Kant) share a conception of what it is to be self-limiting through self-consciousness. I then critically examine this conception, and, specifically, the way in which it fails to account for the most essential form of self-limitation in Kant’s critical philosophy—namely, the form of self-limitation which rejects spatial and temporal articulation. The conclusion we reach is that Kant’s theory of transcendental self-consciousness is a theory of the activity of thinking as determining itself (including its limits) non-spatially and non-temporally. (shrink)

In this paper, I explain why people seeking to flourish together fairly in the im- perfect world we share today ought to support a universal carbon tax with no exception for international aviation. The argument proceeds in four steps. First, I provide a free-standing analysis of emissions behavior at the individual moral level. Second, I offer a picture of ideal and non-ideal coordination based mostly on Kantian social contract theory. Third, I argue that in a non-ideal context, moral signals about (...) right relation offer a coordinating fulcrum around which meaningful if only partly coordinated action is possible. Fourth, I apply these conclusions to the case of aviation exceptionalism, focusing especially on instances of incomplete, overlapping, partly coordinated climate actions. I conclude that these arguments together amount to a case for reversing the Chicago Convention and applying a universal carbon tax that does not exclude international flights, ending aviation exceptionalism. (shrink)

Attempting to make clear different theories of cultural ownership, cultural property scholars have divided dominant views into two categories: cultural nationalism and cultural internationalism. Although not discussed in the relevant literature, I claim it is useful to understand these two categories as comprised of the ethical views of deontology and consequentialism. I claim cultural internationalists believe they have good independent reasons against returning problematic cultural heritage like the Parthenon marbles. However, I will demonstrate their arguments are based on consequentialist ethics, (...) and there are just as many consequentialist reasons to return the marbles as there are for them to remain in the British Museum, undermining cultural internationalist arguments against their return. (shrink)

What might Adam Smith have learned from Jane Austen and other novelists of his moment? This paper finds and examines a serious problem at the center of Adam Smith’s moral psychology, stemming from an unacknowledged tension between the effort of the spectator to sympathize with the feelings of the agent and that of the agent to moderate her feelings. The agent’s efforts will result in her opacity to spectators, blocking their attempts to read her emotions. I argue that we can (...) resolve this tension by looking to developments in eighteenth-century literature, as perfected in the hands of Jane Austen. I focus on two techniques, focalization and free indirect style, and I show that the problems for spectatorship diminish when we see that good Smithian spectators are savvy readers. (shrink)

In summaries of “best practices” for pedagogy, one typically encounters enthusiastic advocacy for metacognition. Some researchers assert that the body of evidence supplied by decades of education studies indicates a clear pedagogical imperative: that if one wants their students to learn well, one must implement teaching practices that cultivate students’ metacognitive skills. -/- In this dissertation, I counter that education research does not impose such a mandate upon instructors. We lack sufficient and reliable evidence from studies that use the appropriate (...) research design to validate the efficacy of metacognitive skill-building interventions (not just evaluate their relationship to learning outcomes). I argue that improved academic outcomes following these interventions aren’t necessarily mediated by increased metacognitive skills; rather, enhanced student performance can be accounted for by other factors that accompany metacognitive training, particularly the explicit provision of domain-specific knowledge. -/- On the way to this conclusion, I elaborate some complications and controversies surrounding “metacognition.” This is a sprawling and nebulous construct, which makes generalizations about its pedagogical value dubious from the outset. Moreover, it is unclear the extent to which the end goal of metacognitive skill-building (cognitive self-mastery, involving knowledge of and control over our own minds) is even possible, given our mental architecture; some cognitive scientists allege that we are subject to phenomenological illusions which make this seem more achievable than it actually is. -/- I also attempt to provide an account of how metacognitive skill-building could receive glowing endorsements from educators and education researchers, even though its conceptual and empirical underpinnings are flimsy. The error theory I offer identifies two major factors that may foster belief in the efficacy of metacognitive training: goalpost-shifting around the objective of such efforts, and motivated reasoning in defense of the desirable conclusion that educators can significantly reshape students’ minds and unlock their intellectual potential through simple pedagogical interventions. (shrink)

This article is an introduction to the special issue on Women in Philosophy: Past, Present and Future. Over the past decade, there has been increased attention given to the underrepresentation of women in academic philosophy, as well as the lack of diversity in philosophy more broadly. While there has been some progress in the demographics of philosophy, as evidenced by recent surveys and empirical studies, women are still significantly outnumbered by men and disparities persist. This special issue aims to address (...) the ongoing problem of inclusion in philosophy by exploring the contribution of women in the field. The contributors have been given freedom to write on topics they consider important, with the hope of stimulating further discussion and generating new ideas for addressing this issue. (shrink)

Academic misconduct is a prominent issue at postsecondary institutions. This issue includes the act of plagiarism, which has received considerable attention on campuses. There is a growing body of research examining why students engage in plagiarism, and what they know about plagiarism, but little of this research is guided by a theoretical framework. Although all students may be tempted to plagiarize, students in teacher education programs represent a unique population because they are concerned with developing their own academic performance alongside (...) the skills necessary to manage situations of academic misconduct as future teachers. Therefore, our first aim was to examine preservice teachers’ beliefs about plagiarism. Then, following the principles of Attribution Theory, our second aim was to investigate how beliefs of controllability related to acts of plagiarism impacted participants views on responsibility, emotions, help giving, and reporting. We used a within-person repeated measures design with three levels of controllability manipulated through hypothetical scenarios of plagiarism to collect data from 201 preservice teachers. Overall, preservice teachers had strong beliefs about plagiarism. Moreover, when scenarios included students who engaged in plagiarism that was controllable, participants were more likely to view the student as responsible, feel anger towards them, support punishment, and recommend reporting the student, than when the act of plagiarism was not seen as controllable. We provide recommendations for instructors and administrators for supporting students and highlight limitations and directions for future research. (shrink)

This essay provides an analysis of the role of affectivity in Martin Heidegger's writings from the mid to late 1920s. We begin by situating his account of mood within the context of his project of fundamental ontology in Being and Time. We then discuss the role of Befindlichkeit and Stimmung in his account of human existence, explicate the relationship between the former and the latter, and consider the ways in which the former discloses the world. To give a more vivid (...) and comprehensive picture of Heidegger's account of mood, we focus on the experience of anxiety by articulating both its function within fundamental ontology and, relatedly, its revelatory nature. We conclude by considering the place of emotions in Heidegger's thinking from this period. In a companion essay, ‘Affectivity in Heidegger II: Temporality, Boredom, and Beyond’, we complement our present analysis by revisiting the issue of affectivity in terms of Heidegger's discussion of temporality in Division II of Being and Time. We also expand our present discussion by considering the fundamental mood of boredom and other specific moods that Heidegger considers within his later thinking. (shrink)

On the background of explaining their different notions of analyticity, their different views on definitions, and some aspects of Frege’s notion of sense, three important Kantian strands that interweave into Frege’s view are exposed. First, Frege’s remarkable view that arithmetic, though analytic, contains truths that “extend our knowledge”, and by Kant’s use of the term, should be regarded synthetic. Secondly, that our arithmetical (and logical) knowledge depends on a sort of a capacity to recognize and identify objects, which are given (...) us in particular ways, constituting their senses (Sinne). Third, that there is a sense in which Frege’s view of definitions and explications gives new substance to Kant’s leading idea of analyticity, namely, the containment of a truth or a concept in another. In all these, Frege’s view does not endorse the Kantian strands as they are, but gives them special and sometimes quite sophisticated twists. (shrink)