Jedna od istaknutih teorijskih koristi pojma utemeljivanja jeste njegova sposobnost da ujedinjuje različite slučajeve metafizičke zavisnosti i determinacije. To pretpostavlja da je sam ovaj pojam jedinstven. Jedinstvo utemeljivanja uobičajeno se prećutno pretpostavljalo među teoretičarima utemeljivanja, ali je s vremenom postalo predmet diskusije usled različitih skeptičkih izazova. U ovom radu ispitaćemo tri najopštije teorije jedinstva utemeljivanja: 1) singularizam − gledište po kojem je je dinstvo utemeljivanja zasnovano na ideji da postoji samo jedna relacija utemeljivanja; 2) generalizam − gledište po kojem utemeljivanje (...) treba razumeti kao generički pojam; i 3) gledište koje tvrdi da jedinstvo utemeljivanja počiva na objektivnim sličnostima među različitim relacijama utemeljivanja. Posebna pažnja biće posvećena trećoj opciji koja je bila u velikoj meri zanemareno gledište. Naša razmatranja će ukazati da ovo stanovište, zahvaljujući svojim inherentnim teorijskim vrlinama, zaslužuje mnogo oz biljniji tretman u metafizičkim raspravama o utemeljivanju. (shrink)

Cilj ovog rada je razmatranje onih aspekata Bolcanove teorije utemeljivanja koji su značajno anticipirali savremene rasprave o utemeljivanju, i koji su dodatno dali podsticaja da se Bolcanov rad ponovo „otkrije“. Stoga ćemo svaki izneti segment njegovog učenja dovesti u vezu s paralelnim idejama u savremenim teorijama utemeljivanja. Na kraju ćemo razmotriti pitanja o značaju i mestu Bolcanovih uvida u kontekstu recentnih rasprava o istoriji pojma utemeljivanja.

The convergence of computing, sensing, and communication technology will soon permit large-scale deployment of self-driving vehicles. This will in turn permit a radical transformation of traffic control technology. This paper makes a case for the importance of addressing questions of social justice in this transformation, and sketches a preliminary framework for doing so. We explain how new forms of traffic control technology have potential implications for several dimensions of social justice, including safety, sustainability, privacy, efficiency, and equal access. Our central (...) focus is on efficiency and equal access as desiderata for traffic control design. We explain the limitations of conventional traffic control in meeting these desiderata, and sketch a preliminary vision for a next-generation traffic control tailored to address better the demands of social justice. One component of this vision is cooperative, hierarchically distributed self-organization among vehicles. Another component of this vision is a priority system enabling selection of priority levels by the user for each vehicle trip in the network, based on the supporting structure of non-monetary credits. (shrink)

Veliko interesovanje za metafizički pojam utemeljivanja poslednjih desetak godina na savremenoj metafizičkoj sceni dovelo je do pojave onih autora koji ne dele isti entuzijazam kao i njegovi zagovornici. U ovom radu osvrnućemo se na skeptičku poziciju koju zastupa Kris Dejli. Osnovni prigovori njegove kritike zasnovani su na ideji da sam koncept utemeljivanja nije razumljiv, odnosno da zagovornici te koncepcije nisu uspeli da to pokažu. U prvom delu rada iznećemo opšti pregled temeljnih karakteristika pojma utemeljivanja i njegove teorijske funkcije, dok ćemo (...) u drugom delu sagledati glavne Dejlijeve prigovore i pokušati da na njih odgovorimo. Na kraju, u zaključnim razmatranjima sumiraćemo glavne poente do kojih smo prethodnim uvidima došli. Pokazaće se da Dejlijevi prigovori nisu dovoljno jaki da dovedu u pitanje razumljivost govora o utemeljivanju. (shrink)

Decision theory and folk psychology both purport to represent the same phenomena: our belief-like and desire- and preference-like states. They also purport to do the same work with these representations: explain and predict our actions. But they do so with different sets of concepts. There's much at stake in whether one of these two sets of concepts can be accounted for with the other. Without such an account, we'd have two competing representations and systems of prediction and explanation, a dubious (...) dualism. Folk psychology structures our daily lives and has proven fruitful in the study of mind and ethics, while decision theory is pervasive in various disciplines, including the quantitative social sciences, especially economics, and philosophy. My interest is in accounting for folk psychology with decision theory -- in particular, for believe and wanting, which decision theory omits. Many have attempted this task for belief. (The Lockean Thesis says that there is such an account.) I take up the parallel task for wanting, which has received far less attention. I propose necessary and sufficient conditions, stated in terms of decision theory, for when you're truly said to want; I give an analogue of the Lockean Thesis for wanting. My account is an alternative to orthodox accounts that link wanting to preference (e.g. Stalnaker (1984), Lewis (1986)), which I argue are false. I argue further that want ascriptions are context-sensitive. My account explains this context-sensitivity, makes sense of conflicting desires, and accommodates phenomena that motivate traditional theses on which 'want' has multiple senses (e.g. all-things-considered vs. pro tanto). (shrink)

You want to see the concert, but don’t want to take a long drive (even though the concert is far away). Such *strongly conflicting desire ascriptions* are, I show, wrongly predicted incompatible by standard semantics. I then object to possible solutions, and give my own, based on *some-things-considered desire*. Considering the fun of the concert, but ignoring the drive, you want to see the concert; considering the boredom of the drive, but ignoring the concert, you don’t want to take the (...) drive. (shrink)

The Industrial Ontologies Foundry (IOF) was formed to create a suite of interoperable ontologies. Ontologies that would serve as a foundation for data and information interoperability in all areas of manufacturing. To ensure that each ontology is developed in a structured and mutually coherent manner, the IOF has committed to the tiered architecture of ontology building based on the Basic Formal Ontology (BFO) as top level. One of the critical elements of a successful tiered architecture build is the domain mid-level (...) ontologies. However, thus far there has been no mid-level manufacturing ontology that is based on BFO. The IOF has recently released the IOF Core version 1 beta to fill this gap. This paper documents the development process and gives an overview of the current content of the IOF Core. Finally, the paper describes how the IOF Core can be used as the basis for a more domain-specific Supply Chain Ontology. (shrink)

This paper deals with Schaffer’s distinction between metaphysical structures, as well as his appeal for revival of neo-Aristotelian approaches that imply ordered structure, based on the criticism of Quine’s method that, in his view, implies flat metaphysical structure. However, although we believe that Schaffer’s distinction between metaphysical structures is an interesting and, basically, acceptable view, we will try to show that Schaffer’s arguments are not convincing enough to persuade us to abandon Quine’s method and adopt the Aristotelian metaphysical model. Moreover, (...) when mistakes that Schaffer makes are corrected and Quine’s method is given due attention, we will see that this can enable us a more tenable interpretation of the concepts that Schaffer speaks of (metaphysical structures), but also – as in his case – to draw certain conclusions that go beyond objectives of classification as such. (shrink)

According to the Desiderative Lockean Thesis, there are necessary and sufficient conditions, stated in the terms of decision theory, for when one is truly said to want. What one is truly said to want, it turns out, varies remarkably by context—and to an underappreciated degree. To explain this context-sensitivity, and closure properties of wanting, I advance a Desiderative Lockean view that is distinctive in having two context-sensitive parameters.

This paper suggests two ideas. The first boils down to a meta-ethical thesis that in situations of “crisis” (such as the ongoing pandemic), the language is among the first to die as a system of rational agreement. Another idea is that radical attitudes, specifically pro and contra attitudes, still can be represented sensibly. The author illustrates this thesis in examples of Kant and Mill’s classical ethical theories.

The subject of this paper is Charles Morris’ semiotic theory that has as one of its major projects the unification of all sciences of signs. However, since the above project has proven to be unsuccessful, we will try to examine here the reasons that led to this. Accordingly, we will argue that to transcend the particularities of individual disciplines that he wanted to unify, Morris had to make certain ontological assumptions, instead of theoretical and methodological ones, that they could share. (...) However, because the 'sign' as an ontological category could in our view only be established if we follow the principles of the pragmatic philosophical tradition, we will try to show that the reasons for this failure should be primarily sought in different effects that consistent application of the pragmatic principles has in each of them (primarily in linguistics and the philosophy of language). On the other hand, this should enable us to draw several important conclusions regarding Morris’ project: namely, that his failure does not have to mean giving up semiotics as a potentially key discipline in approaching some fundamental philosophical problems, but also that it would demand return to the original semiotics developed in Peirce’s works. (shrink)

Although Williams’ contextual thesis is above all a critique of one way of interpreting contextualism in epistemology, viz., simple conversational contextualisam, I will argue that this thesis has also been a very successful means for the critique of a standpoint on which that interpretation, and the entire traditional epistemology rests - epistemological realism. Accordingly, in spite of certain weaknesses in Williams’ position pointed out by his critiques, in this paper I will try to show that, by interpreting the problem of (...) scepticism as first and foremost a methodological necessity of epistemological realism, Williams succeeds in offering an enlightening diagnosis of the sceptical paradox problem which is at the centre of epistemology traditionally construed. (shrink)

In this paper we will try to show the differences between Quine’s and Gibson’s interpretation of the naturalized epistemology project. Namely, although Gibson points out that the genetic approach advocated by Quine is the best strategy there is to investigate the relations between evidence and theory, and that externalizing of empiricism that it requires is one of Quine’s major philosophical contributions, we argue that the assumptions on which Gibson’s project is based, apart from the fact that they are in conflict (...) with some strongly held intuitions, would have to be essentially different from Quine’s. In other words, contrary to Quine’s position within which we have the possibility of staying on more moderate, and in our opinion, more plausible behavioristic line of approach, we will try to show that one of the consequences of Gibson’s interpretation is that this possibility is ruled out in Gibson’s case. On the other hand, this should enable us to draw some more radical conclusions about the nature of Quine’s epistemological project. (shrink)

In this paper, we will try to confront Quine’s and Davidson’s holistic position through Davidson’s thesis of the mental as a non-ontological category. In this regard, since Davidson came to this position through the thesis of the mental as a decidedly conceptual category, we will try to show how this approach does not, nevertheless, rule out the possibility of its interpretation in ontological terms. However, in what follows we will draw attention to the fact that the mental can be interpreted (...) so that it proves to be immune to ontologizing in Quine’s sense. This would be the evidence of different ways, which are not necessarily compatible, to argue for Davidson’s central thesis - the thesis about holistic character of the mental - as well as, which is closely related, a certain difference that exists between Davidson’s view of the mental as a conceptual category on the one hand, and a holistic category on the other. (shrink)

This paper deals with Peirce’s understanding of perceptual judgment, relating it to the conditions for the use of language defined by Michael Dummett. Namely, drawing on Dummett’s requirement for harmony between descriptive and evaluative aspects of our linguistic practice, we will try to give an interpretation of Peirce’s view of perception that implies rejecting the idea that the formation of a perceptual judgment has an inferential structure. On the other hand, since it is, in Peirce’s opinion, the structure of abductive (...) inference, this approach should enable us to draw some conclusions related to abduction in general. (shrink)

Meet Tega. Blue, fluffy, and AI-enabled, Tega is a relational robot: a robot designed to form relationships with humans. Created to aid in early childhood education, Tega talks with children, plays educational games with them, solves puzzles, and helps in creative activities like making up stories and drawing. Children are drawn to Tega, describing him as a friend, and attributing thoughts and feelings to him ("he's kind," "if you just left him here and nobody came to play with him, he (...) might be sad"). Scholars and members of the public alike have raised the alarm about relational robots, worrying that the relationships that people, and especially children, form with such robots are objectionably inauthentic. We, members of an interdisciplinary team that developed and studies Tega, make this inauthenticity worry precise and offer practical recommendations for addressing it. We distinguish two kinds of (in)authenticity -- inauthenticity as unreality, and inauthenticity as deception -- arguing that neither is just what others have thought it is. With our distinction in hand, we argue that the authenticity concern can be met only through co-design methods -- methods that give stakeholders of all kinds (e.g. parents, educators, and children themselves) a genuine say in how relational robots are built. (shrink)

Recently, two new portrayals of Kripke’s Wittgenstein have emerged. Both understand KW as targeting the Tractarian picture of semantic fact as a speaker’s mental representation of the truth-conditions of the sentences he uses. According to the factualist interpretation, KW holds that meaning ascriptions are legitimate descriptions because semantic facts are not entities that explain people’s linguistic behavior. The second, Alex Miller’s non-standard non-factualist interpretation, sees KW as claiming that because no fact can explain our linguistic behavior, meaning ascriptions express a (...) speaker’s attitudes towards his interlocutors rather than stating what they mean. This paper advances the minimal factualist interpretation by elaborating two points: that Miller’s reading of the skeptical argument contradicts semantic non-factualism; and that KW’s view of meaning is based on a primitivist rendition of the skeptic’s insight that nothing justifies our use of language, which allows him to assert that semantic facts exist simply because we ordinarily say so. (shrink)

The statement everyone wants to live a fulfilled and happy life may seem simple, self-evident, and even trivial at first glance. However, upon closer philosophical analysis, can we unequivocally assert that people are truly focused on well-being? Assuming they are, the question becomes: what guidelines should be followed and how should one behave in order to achieve true well-being and attain their goals? One popular viewpoint is that cultivating moral virtues and personal qualities is essential for a life of "true" (...) well-being, rather than mere pleasure. This perspective is not particularly original, as it was advocated quite clearly by Aristotle. However, we must ask: what guarantees that virtue will lead to well-being? Can we really ignore the common-sense doubt that virtue (and moral life), as Kant points out, may not be rewarded with any form of well-being or "happiness" in the broadest sense during our earthly existence? How might we address this doubt? If questions about the relationship between happiness and virtue have been asked since ancient times, why don't we have definitive answers yet? Perhaps there is something wrong with the questions themselves, as is often the case in philosophy. Views on this relationship have influenced the modification of theories that philosophers have put forth in order to provide satisfactory answers. One such theory is the renewed and modernized ethics of virtue, which places the greatest emphasis on building an individual's moral character, assuming that Aristotelian character virtues such as courage, honesty, generosity, prudence, self-control, and compassion will enable us to lead a happy and fulfilling life. "Virtues" refer to a wide range of "excellences" or activities that individuals can use to perfect themselves. For example, an ordinary person might accept that courage can make their life more fulfilling, but it's important to recognize that virtues cannot be acquired overnight. Furthermore, many people believe that virtues are innate qualities that one either possesses or lacks. In contrast, ethics of virtue provides guidance and instructions for developing virtues over extended periods of time, as well as for continuously "practicing" the development of moral characteristics that will make us better individuals. The central and most significant concept in ethics of virtue is the golden mean, which can be interpreted in various ways. Essentially, ethics of virtue offers a path to a life filled with pleasure, harmony, and virtuous action. However, this collection of essays, Virtues and Vices: Between Ethics and Epistemology, is not exclusively concerned with virtues or ethics. Knowledge, as well as the processes of belief formation and justification of those beliefs, are also essential to ethics of virtue. Going back to the systematic Greek philosopher and his teacher, we can emphasize that virtues and knowledge are inseparable. Without the epistemology of virtues, even a thematic collection like this one would be incomplete. The Epistemology of Virtue is a relatively new branch of philosophy that has emerged as a response to questions about the value-neutrality of science. For a long time, the separation of values and scientific inquiry has been viewed as the correct methodological approach. However, it is clear that every scientist is also a human being with their own virtues and flaws. It is naive to assume that a scientist can leave their values and moral qualities outside the laboratory and treat their colleagues in the team differently than they would treat other people in their everyday life. Taking this into account, we can notice that Epistemology of Virtue is a theory that examines the influence of virtues on the processes of acquiring knowledge. Epistemic virtues refer to qualities that enable individuals to acquire knowledge and make reliable judgments. These virtues include traits such as openness to diverse testimonies and arguments, critical thinking, a tendency to question one's own assumptions, and the ability to identify errors in one's own thought processes. Just like in virtue ethics, the Epistemology of Virtue raises the question of how we can cultivate the necessary virtues and how these virtues can have a positive impact on both individuals and society. The field also explores how epistemic virtues can be put into practice, such as in educational settings, scientific research, and various social activities. Finally, we turn to a topic that is often overlooked in philosophy - human flaws. While ethics typically views flaws as the opposite of virtues, requiring correction both individually and socially, the Epistemology of Virtue questions what happens when flaws occur in knowledge-related qualities. Do these flaws also need to be eliminated, or are they an inherent part of the process of acquiring knowledge and making judgments? At first glance, prejudices, stereotypes, dogmatism, conformism, closed-mindedness towards arguments and evidence, as well as uncritical acceptance of authority, can all hinder our ability to acquire knowledge. Epistemologists view these qualities as vices, rather than flaws like ethicists do. The Epistemology of Vices is the newest of the three branches of philosophy covered in this thematic collection, and it examines the ways in which false and untrue beliefs develop and persist in society. This area of study seeks to answer questions about how people form delusions and whether it is possible to overcome them. On the other hand, the Epistemology of Virtue is like the "older brother" that supervises these vices. It contributes to the investigation and overcoming of vices by developing virtues that enable individuals to more accurately assess the truthfulness of their beliefs. However, even though vices can have a destructive impact on knowledge acquisition, the question remains: are vices always detrimental in every context? Conversely, can virtues be detrimental? For example, does a virtue like solidarity sometimes hinder the efficient formation of true beliefs in time-sensitive situations such as finding a vaccine to combat a virus pandemic? Can vices be useful? Can stubbornness and uncooperativeness sometimes help a research team by allowing two sides to reach the same goal through different paths? Within this collection, some of these questions will receive answers, some of which may confirm existing impressions, while others may surprise readers. The thematic collection, Virtues and Vices: Between Ethics and Epistemology, consists of four interesting chapters and 21 papers that cover the selected topic through the prism of philosophical disciplines such as ethics, epistemology, the history of philosophy, philosophy of mind, political philosophy, and philosophy of science. In this introduction, we will not discuss the contents of the articles so as not to disrupt the intended integral approach to reading the collection. A significant feature of this collection is the continuity that extends from one paper to another, from topic to topic, and from problem to problem. Lastly, we would like to express our gratitude to the Faculty of Philosophy at the University of Belgrade for their support in realizing this collection, as well as to our colleagues from the Department and Institute of Philosophy who have made this collection a relevant and significant achievement with their contributions. We are also thankful to the reviewers of the collection as a whole, as well as to the referees of individual articles, who have provided us with detailed comments and remarks that have made this collection clearer and more comprehensive. We owe a special thanks to our colleagues from Zagreb, Rijeka, and Maribor, whose exceptional papers have contributed to making this collection an unabashed international contribution to debates about the ethics and epistemology of virtues and vices. (shrink)

What are the truth conditions of want ascriptions? According to an influential approach, they are intimately connected to the agent’s beliefs: ⌜S wants p⌝ is true iff, within S’s belief set, S prefers the p worlds to the not-p worlds. This approach faces a well-known problem, however: it makes the wrong predictions for what we call (counter)factual want ascriptions, wherein the agent either believes p or believes not-p—for example, ‘I want it to rain tomorrow and that is exactly what is (...) going to happen’ or ‘I want this weekend to last forever, but of course it will end in a few hours’. We solve this problem. The truth conditions for want ascriptions are, we propose, connected to the agent’s conditional beliefs. We substantiate this connection by pursuing a striking parallel between (counter)factual and non-(counter)factual want ascriptions on the one hand and counterfactual and indicative conditionals on the other. (shrink)

Fears of black-box algorithms are multiplying. Black-box algorithms are said to prevent accountability, make it harder to detect bias and so on. Some fears concern the epistemology of black-box algorithms in medicine and the ethical implications of that epistemology. Durán and Jongsma (2021) have recently sought to allay such fears. While some of their arguments are compelling, we still see reasons for fear.

Algorithms wield increasing control over our lives—over the jobs we get, the loans we're granted, the information we see online. Algorithms can and often do wield their power in a biased way, and much work has been devoted to algorithmic bias. In contrast, algorithmic neutrality has been largely neglected. I investigate algorithmic neutrality, tackling three questions: What is algorithmic neutrality? Is it possible? And when we have it in mind, what can we learn about algorithmic bias?

The compelling, widely-accepted Satisfaction-is-Truth Principle says that if S wants p, then S has a desire that's satisfied in exactly the worlds where p is true. We reject the Principle; an agent may want p without having a desire that's satisfied when p obtains in any old way. Other theorists who reject the Principle rely on contested intuitions about when agents get what they want. We instead appeal to—and shed new light on—the dispositional role of desire.

In this pa­per we aim to pin­po­int so­me of the key mar­kers of the de­velop­ment of lo­gic in Ser­bia, star­ting from the fo­un­ding of the Lyce­um in 1836 un­til the end of the 19th cen­tury. Our main goal is to un­der­li­ne the ro­le that Lju­bo­mir Ne­dić, a phi­lo­sop­her and li­te­rary cri­tic, had in this con­text. Alt­ho­ugh he did not le­a­ve any ori­gi­nal con­tri­bu­ti­ons in lo­gic, Ne­dić played a sig­ni­fi­cant part by ex­po­sing con­tem­po­rary re­sults in symbo­lic lo­gic, which we­re to lead, (...) thro­ugh Fre­ge’s la­ter work, to the cre­a­tion of mo­dern lo­gic. (shrink)

A compositional semantics for anankastic conditionals (‘If you want p, you must φ’) has been elusive. Condoravdi and Lauer (2016) decisively object to all semantics that precede their own. CL's view rests on a response to *the problem of conflicting goals*; CL use an interpretation of 'want' on which an agent's desires don't conflict with her beliefs. But a proper response requires lack of conflict with the facts. CL's view fails. Anankastic conditionals are still a mystery.

In his Education of a Christian Prince Erasmus applies ancient and Christian virtues to the functions of a Christian prince. Slovak humanist writer Ján Milo- chovský , who new Erasmus’s work, expanded in his Ornamentum Magistratus Politici the scope of the ethical and moral functions of a prince, focusing on three fundamental virtues: piety, justice and tolerance.The paper offers an analysis of Erasmus’s political ethics and examines the impact of the latter on the Slovak humanism of the second half of (...) the 17th century, especially in the writings of Ján Milochovský. (shrink)

« Ce petit livre est un bijou d’intelligence, de finesse, de culture, qui prend un objet technique sans rechigner et le tourne et le retourne comme Heidegger nous avait appris à le faire avec les chaussures de Van Gogh. Ce qui frappe, c’est l’ambition d’une méditation sur les cartes de la modernité contemporaine, sur le fameux Grand Paris, sur le sujet, sur le pluriel, sans les faux-fuyants du postmoderne, de la citation absurde. Luis de Miranda se promène, il vous conte (...) qu’il se promène, mais il vous mène avec une grande maîtrise et sait où il veut aller. Rien de gratuit dans cette rencontre de l’enseigne de kebabs sur la table de dissection de la Ville Néon. C’est plutôt une nouvelle méditation cartésienne après Descartes et Husserl : où le poêle et sa chaleur ont fait place au bruit vrillant du gaz dans un tube. Je suis, je crée, donc j’entends. » Yann Moulier-Boutang, ancien élève de l’ENS, professeur agrégé d’économie à l’université de technologie de Compiègne, directeur de la revue Multitudes. Né d’une rencontre inopinée avec un néon sur le quai du Louvre, ce livre a été composé à partir d’un séminaire donné par l’auteur à l’hiver 2012. Un voyage inspiré à travers la nuit, qui déchiffre les halos du passé et les reflets du présent pour donner à entendre une certaine magie du futur. Luis de Miranda, philosophe, romancier, révélateur du créalisme, est notamment l’auteur d’un essai remarqué, L’art d’être libres au temps des automates (Max Milo, 2010). (shrink)

Srpska recepcija grčke filozofije od Velikog rata do sredine XX veka (Anica Savić Rebac, Ksenija Atanasijević, Miloš N. Đurić).

This is basically a paper about artistic evaluation and how multiple interpretations can give rise to inconsistent and conflicting meanings. Images like Joel-Peter Witkin’s First Casting for Milo (2004) challenge the viewer to look closely, understand the formal properties at work, and then extract a meaning that ultimately asks, Is the model exploited or empowered? Is Karen Duffy, pictured here, vulnerable and “enfreaked” or is she potentially subversive, transgressive, and perhaps self-empowered? I will offer an argument in agreement with artist/author/ (...) performer Ann Millett-Gallant that favors the latter interpretation, but will augment and complicate the issue by also introducing a pointed question or two taken from a recent analysis by Cynthia Freeland on objectification. I judge the works by photographer Joel-Peter Witkin to be representations of disabled persons who are empowered through agency and pride, but I also worry about the risk of multiple, conflicting interpretations on the part of viewers who do not, or cannot, entertain such enlightened readings. Like second wave feminist views about pornography that depicted women in demeaning ways, or feminist critiques of Judy Chicago’s The Dinner Party , Witkin’s photos can be judged as potentially offensive. But they are also objects of beauty—both in terms of aesthetic properties (they are magnificent studies in black and white, shadows, the human body, with many classical references) and because of the feeling of beauty and pride felt by the posers, who become performers of their own beauty and pride. I argue that beauty trumps offensiveness. Pride wins. But I’m not sure that everyone will agree. (shrink)

FISIOLOGIA DA REPRODUÇÃO BOVINA -/- 3 – GESTAÇÃO -/- -/- INTRODUÇÃO -/- -/- O estabelecimento da gestação é o objetivo fundamental dos programas reprodutivos. Após a fertilização, o zigoto se divide e dá origem a embriões de duas, quatro, oito, dezesseis células, e no sétimo dia o embrião tem mais de 80 células. Entre os dias 16 e 18 do ciclo estral, o embrião se alonga e atinge 15 cm de comprimento. O estabelecimento da gestação depende da supressão da secreção (...) de PGF2α pelo embrião, que é realizada por meio da secreção de interferon-τ. Em vacas leiteiras, uma alta proporção de embriões morre antes do reconhecimento materno da gravidez. -/- Para evitar perdas embrionárias, é importante conhecer a fisiologia da gestação. Este capítulo descreve os principais processos fisiológicos que levam ao estabelecimento e manutenção da gestação e ao manejo da vaca prenhe. -/- -/- 3.1 Transporte de gametas -/- -/- Os gametas, óvulo e esperma, são definidos como células germinativas maduras que possuem um número haploide (n = 23) de cromossomos que, quando unidos, dão origem a um novo indivíduo geneticamente diferente de ambos os pais. -/- -/- 3.1.1 Transporte dos espermatozoides -/- -/- Os espermatozoides obtidos diretamente do testículo são funcionalmente imaturos, incapazes de fertilizar o óvulo. Durante sua permanência no epidídimo, os espermatozoides sofrem alterações na morfologia, mobilidade e metabolismo, o que lhes dá a capacidade de fertilização. No entanto, eles terão que passar algum tempo no trato genital feminino para que adquiram o estado ideal para fertilizar; processo conhecido como capacitação. -/- Durante a monta natural, a ejaculação ocorre na vagina e são depositados cerca de 5 x 109 de espermatozoides (volume ejaculado de três a cinco ml e concentração espermática de 1 x 109 a 1,2 x 109 por ml) suspensos no plasma seminal, este é basicamente constituído pelas secreções das vesículas seminais e da próstata. Após a ejaculação, o transporte dos espermatozoides é favorecido pelas contrações uterinas e vaginais que ocorrem durante e após a relação sexual. Nos primeiros minutos após a cópula, os espermatozoides já podem ser encontrados no oviduto, o que se deve às contrações do trato genital. Durante o transporte dos espermatozoides, a mobilidade individual é importante, já que apenas os espermatozoides com essa capacidade chegam ao local da fertilização. -/- O primeiro local para o estabelecimento de uma população de espermatozoides é a cérvix do útero, principalmente nas criptas, onde permanecem protegidos da fagocitose. É importante observar que apenas os espermatozoides móveis permanecem nas criptas; aqueles que estão mortos ou sem movimento são eliminados pelos fagócitos ou pelo movimento do muco cervical em direção a vagina. Embora uma população temporária de espermatozoides seja estabelecida no colo do útero, o reservatório funcional de espermatozoides está localizado na região distal do istmo. -/- As características do muco cervical são importantes para o transporte dos espermatozoides; assim, durante o estro e a ovulação, o muco fica mais aquoso, o que favorece a migração dos espermatozoides, enquanto na fase lútea o muco torna-se mais viscoso, dificultando sua movimentação. -/- Já no útero, o transporte de espermatozoides depende principalmente das contrações uterinas. Aqui, os espermatozoides ficam suspensos nas secreções uterinas, cuja função é promover sua viabilidade e transporte. As secreções uterinas contêm fagócitos que removem os espermatozoides mortos e imóveis, embora os espermatozoides normais também sejam removidos por esse meio. Algumas substâncias, como prostaglandinas e ocitocina, promovem o transporte. -/- O oviduto desempenha um papel muito importante no transporte e maturação dos gametas, bem como na fertilização e desenvolvimento embrionário inicial. As características das secreções do oviduto variam de acordo com a região do oviduto e o estágio do ciclo estral. Uma vez que os espermatozoides atingem o oviduto, eles são distribuídos em dois lugares. Alguns espermatozoides são imediatamente transportados para a região da ampola; esses são os primeiros que encontram o ovócito, mas sua capacidade de fertilização é limitada. O outro local de distribuição é a região caudal do istmo; aqui eles permanecem até que a ovulação seja iminente. Para que a fertilização ocorra, é necessário que o espermatozoide se estabeleça neste local por um período de seis a oito horas, antes da ovulação. Uma a duas horas, antes da ovulação, um movimento ativo do espermatozoide é observado em direção à região da ampola. -/- No oviduto, o transporte de espermatozoides depende de seu movimento, do fluido ovidutal e das contrações musculares. É comum que alguns espermatozoides continuem seu movimento e saiam pela fímbria. A viabilidade do espermatozoide de uma ejaculação varia de 24 a 48 horas. -/- -/- 3.1.2 Transporte do ovócito -/- -/- A ovulação é o processo pelo qual o ovócito é liberado. Este evento é desencadeado pela secreção de LH conhecida como pico de LH ovulatório ou pré-ovulatório. -/- Devido ao efeito de LH o cúmulos descola-se da parede folicular e começa a observar-se um adelgaçamento em uma pequena área da parede folicular, causada pela isquemia e pela ação de enzimas proteolíticas. Mais tarde, nesta área, uma pequena vesícula protuberante (estigma) se forma e eventualmente se quebra. Depois que o estigma é quebrado, o cúmulos que contém o ovócito junto com as células da granulosa. O ovócito é capturado pela fimbria; processo apoiado por movimentos dos cílios da mucosa e por contrações das pregas desta estrutura. Assim que o oócito é capturado, ele é transportado para a ampola. -/- 3.8 Manejo da vaca seca -/- -/- Em programas de manejo anteriores, a vaca seca recebia comida de pior qualidade e permanecia no esquecimento até o parto ocorrer. No entanto, os resultados dos estudos mostram que o período de seca é decisivo para que a vaca atinja um nível ótimo de produção e tenha um bom desempenho reprodutivo pós-parto. Por outro lado, o manejo correto no período seco reduz a incidência de doenças metabólicas no puerpério. O objetivo do período de seca é oferecer um descanso à vaca antes do parto, durante o qual o tecido mamário se regenera, o feto atinge seu crescimento máximo e a vaca atinge uma condição corporal adequada para enfrentar uma nova lactação. A duração recomendada do período de seca é de seis a oito semanas (60 dias). A involução do tecido da glândula mamária leva de duas a três semanas e um período semelhante é necessário para reiniciar a síntese do leite antes do parto. Assim, um período de seca de 60 dias é suficiente; entretanto, a duração desse período é questionada e tempos mais curtos foram propostos. Provavelmente, nos próximos anos, mais informações estarão disponíveis para apoiar a redução do período de seca. -/- Em termos de produção, o objetivo do manejo durante o período de seca é levar a vaca ao pico de lactação cinco a seis semanas após o parto, com produção máxima de leite. Estima-se que para cada kg de leite que aumenta no pico da lactação, ocorre um aumento de 120 kg ao longo da lactação. Para atingir este objetivo é necessário que a vaca tenha um consumo adequado de matéria seca após o parto; porém, três semanas antes do parto, a vaca reduz seu consumo em até 30%, para o qual é necessário estabelecer um manejo eficaz para promover um alto consumo de matéria seca durante a parte final do período de seca e durante as três primeiras semanas pós-parto (período de transição: três semanas antes e três após o parto). -/- A falta de capacidade de consumir as necessidades de matéria seca após o parto obriga a vaca a mobilizar suas reservas de gordura. Praticamente todas as vacas após o parto mobilizam suas reservas de gordura e perdem a condição corporal. A mobilização da gordura corporal causa degeneração gordurosa do fígado e é responsável por distúrbios metabólicos e retardo da atividade ovariana pós-parto. O grau de degeneração da gordura está relacionado à magnitude da mobilização da gordura corporal, que é diretamente dependente da capacidade de consumir matéria seca. Dessa forma, vacas com alto consumo de matéria seca no pós-parto, mobilizam menos gordura e, portanto, o dano ao fígado é menor. -/- O período de secagem é dividido em duas partes, a primeira compreende desde a secagem até duas semanas antes do parto; a segunda parte inclui as últimas duas semanas de gestação e é conhecida como período de desafio. -/- O período de desafio é decisivo para o desempenho produtivo e reprodutivo. Durante este período, uma dieta semelhante em ingredientes e forma deve ser oferecida à dieta que farão após o parto. Para facilitar esse manejo, as vacas deste grupo devem ser separadas do restante das vacas secas. -/- No período de seca, atenção especial deve ser dada para que as vacas não alcancem escores de condição corporal de quatro ou mais, uma vez que o excesso de gordura causa problemas metabólicos durante o puerpério, que afetam negativamente o comprometimento uterino e início da atividade ovariana pós-parto (figura 8). -/- -/- -/- Figura 8: Estágios fisiológicos e reprodutivos da vaca leiteira. Período de espera voluntário (PVE). -/- -/- 3.9 O período de transição -/- -/- O período de transição na vaca leiteira é três semanas antes e três após o parto (também conhecido como periparto). Nos últimos anos, esse tema tem merecido muitas pesquisas, pois o que for bem ou mal feito durante ele terá impacto na eficiência reprodutiva e na produção de leite. Durante o período de transição, a glândula mamária se prepara para a lactogênese, o feto cresce exponencialmente, a resposta imune é suprimida e o consumo de matéria seca diminui; além disso, o rúmen deve se adaptar à dieta recebida pelas vacas in natura (primeiras três semanas pós-parto), dieta caracterizada por alto teor de energia na forma de grãos. -/- Muitos distúrbios que se manifestam nas duas primeiras semanas pós-parto (hipocalcemia clínica e subclínica, cetose, retenção placentária, prolapso uterino, metrite, mastite, deslocamento do abomaso etc.), como os que se apresentam posteriormente (laminite, cistos ovarianos , endometrite e anestro) têm sua origem nos erros cometidos durante o período de transição. Em grande parte, os problemas estão relacionados à diminuição do consumo de matéria seca durante o período de transição; assim, o consumo diminui cerca de 30% durante as últimas três semanas de gestação, mas a maior parte da redução ocorre cinco a sete dias antes do parto. O manejo correto do período de transição tem como objetivo manter a normocalcemia, fortalecer o sistema imunológico, adaptar o rúmen a uma dieta rica em energia e aumentar a ingestão de matéria seca. Algumas recomendações gerais de manejo durante o período de transição são: separar as novilhas das vacas, ter comedouro suficiente para todos os animais, ter as mesmas características dos comedouros de vacas frescas e a dieta deve estar disponível 24 horas por dia (figuras 9 e 10). -/- -/- -/- Figura 10: O desempenho produtivo e reprodutivo das vacas depende em grande parte da condição corporal no momento do parto. Nesta fotografia são mostradas vacas recém-paridas, com uma condição corporal ideal (3,5). -/- Figura 9: Vacas no curral do desafio. Recomenda-se separar as novilhas das vacas, ter espaço suficiente com comedouro e a dieta deve estar disponível 24 horas por dia. -/- -/- RESUMO -/- -/- Cerca de 5 bilhões de espermatozoides são depositados em a genitália da vaca durante a cópula. Os espermatozoides devem permanecer no istmo e na região da junção útero-tubária por seis a oito horas antes da ovulação para obter uma alta taxa de fertilização. A viabilidade dos espermatozoides no útero é de 24 a 48 horas. A polispermia é efetivamente bloqueada nas primeiras 10 horas após a ovulação. Os blastômeros de embriões de duas, quatro e oito células são pluripotentes. A eclosão do embrião ocorre no oitavo dia. O tempo que o embrião leva para chegar ao útero é de três a quatro dias. Entre os dias 16 e 18 do ciclo, o embrião produz interferon-t, para bloquear a secreção de PGF2α. Entre os dias 17 e 18, o embrião se fixa ao endométrio. A medição da progesterona entre os dias 20-24 pós-infecção é 100% precisa na identificação de vacas não gestantes. A vaca deve atingir seu pico de lactação entre cinco e seis semanas após o parto. Para cada kg de leite que é aumentado no pico da lactação, um aumento de 120 kg é alcançado na lactação de 305 dias. Três semanas antes do parto, a vaca reduz seu consumo em até 30%. O período de transição inclui três semanas antes e três após o parto. As vacas ao parto não devem ter mais do que quatro pontos de condição corporal. A proporção de vacas secas deve ser de 15% (12,5% de vacas secas e 2,5% de novilhas). -/- -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- -/- BEARDEN, Henry Joe et al. Applied animal reproduction. Reston Publishing Company, Inc., 1984. -/- Endocrinologia da Reprodução Animal. Recife, UFRPE, 2020. -/- Fisiologia da Reprodução Animal: Fecundação e Gestação. Recife: UFRPE, 2020. -/- HAFEZ, Elsayed Saad Eldin; HAFEZ, Bahaa. Reprodução animal. São Paulo: Manole, 2004. -/- HIDALGO, Galina et al. Reproducción de animales domésticos. México: Limusa, 2008. -/- HOLY, Lubos; MARTÍNEZ JÚSTIZ, G. Colab. Biología de la reproducción bovina. Havana: Revolucionária, 1975. -/- HOPPER, Richard M. (Ed.). Bovine reproduction. John Wiley & Sons, 2014. -/- LEBLANC, Stephen. Monitoring metabolic health of dairy cattle in the transition period. Journal of reproduction and Development, v. 56, n. S, p. S29-S35, 2010. -/- SARTORI, Roberto; BASTOS, Michele R.; WILTBANK, Milo C. Factors affecting fertilisation and early embryo quality in single-and superovulated dairy cattle. Reproduction, Fertility and Development, v. 22, n. 1, p. 151-158, 2009. -/- SENGER, Phillip L. et al. Pathways to pregnancy and parturition. Current Conceptions, Inc., 1615 NE Eastgate Blvd., 1997. -/- VIVEIROS, Ana Tereza de Mendonça. Fisiologia da reprodução de bovinos. Lavras: UFLA, p. 62, 1997. (shrink)