We present SASC, Self-Adaptive Semantic Crossover, a new class of crossover operators for genetic programming. SASC operators are designed to induce the emergence and then preserve good building-blocks, using metacontrol techniques based on semantic compatibility measures. SASC performance is tested in a case study concerning the replication of investment funds.

The biomedical literature makes extensive use of the concept of a genetic program. So far, however, the nature of genetic programs has received no satisfactory elucidation from the standpoint of computer science. This unsettling omission has led to doubts about the very existence of genetic programs, on the grounds that gene regulatory networks lack a predetermined schedule of execution, which may seem to contradict the very idea of a program. I show, however, that we can (...) make perfect sense of genetic programs, if only we abandon the preconception that all computers have a von Neumann architecture. Instead, genetic programs instantiate the computational architecture of Post–Newell Production Systems. That is, genetic programs are unordered sets of conditional instructions, instructions that fire independently when their conditions are matched. For illustration I present a paradigm Production System that regulates the functioning of the well-known lac operon of E. coli. On close reflection it turns out that not only genes, but also proteins encode instructions. I propose, therefore, to rename genetic programs to biomolecular programs. Biomolecular and/or genetic programs, and the cellular computers than run them, are to be understood not as von Neumann computers, but as Post–Newell production systems. (shrink)

The notion of a genetic program has been widely criticized by both biologists and philosophers. But the debate has revolved around a narrow conception of what programs are and how they work, and many criticisms are linked to this same conception. To remedy this, I outline a modern and more apt idea of a program that possesses many of the features critics thought missing from programs. Moving away from over-simplistic conceptions of programs opens the way to (...) a more fruitful interplay of ideas between the complexity of biology and our most complex engineering discipline. (shrink)

This paper outlines a critique of the use of the genetic variance–covariance matrix (G), one of the central concepts in the modern study of natural selection and evolution. Specifically, I argue that for both conceptual and empirical reasons, studies of G cannot be used to elucidate so-called constraints on natural selection, nor can they be employed to detect or to measure past selection in natural populations – contrary to what assumed by most practicing biologists. I suggest that the search (...) for a general solution to the difficult problem of identifying causal structures given observed correlation’s has led evolutionary quantitative geneticists to substitute statistical modeling for the more difficult, but much more valuable, job of teasing apart the many possible causes underlying the action of natural selection. Hence, the entire evolutionary quantitative genetics research program may be in need of a fundamental reconsideration of its goals and how they correspond to the array of mathematical and experimental techniques normally employed by its practitioners. (shrink)

In this new post-genomic age of medicine and biomedical technology, there will be novel approaches to understanding disease, and to finding drugs and cures for diseases. Hundreds of new “disease genes” thought to be the causative agents of various genetic maladies will be identified and added to the list of hundreds of such genes already identified. Based on this knowledge, many new genetic tests will be developed and used in genetic screening programs. Genetic screening is (...) the foundation upon which reproductive technologies such as pre-natal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are based. Genetic information arising from the human genome may also be used in attempts to redesign the human genetic inheritance by engineering the human germline (germline engineering). In each of these technologies—PND, PGD, and germline engineering—there are serious ethical and social concerns. Moreover, all three are eugenic in nature because they strive to control which genes are passed down to future generations. The goals of this article are threefold: 1) to introduce the science behind the three technologies; 2) to give a brief overview of eugenics in the past century and show how these genetic technologies are eugenic; and 3) to present a vision of social justice that rejects the genetic determinism upon which eugenics is based and embraces a holistic, ecological view of nature and humanity. (shrink)

This article presents a two level hierarchical forecasting model developed in a consulting project for a Brazilian magazine publishing company. The first level uses a VARMA model and considers econometric variables. The second level takes into account qualitative aspects of each publication issue, and is based on polynomial networks generated by Genetic Programming (GP).

Distributive justice is one of the central questions of contemporary moral and political philosophy. Discussions on this topic are often presented as a confrontation between two groups of thinkers: libertarians and luck egalitarians. The former emphasize the dependence of the existing distribution on the individual choice and personal responsibility of people, and therefore are skeptical about various redistribution programs. The latter, on the contrary, emphasize the influence of morally arbitrary luck on the economic situation of people, and therefore welcome (...) redistributive measures to compensate for this brute luck. Left-libertarian claims to reconcile these two types of moral considerations. The classical left-libertarian point of view seeks to offset the influence of brute luck through an egalitarian distribution of the benefits of owning natural resources that are independent of anyone’s choice and responsibility. However, this position does not sufficiently take into account the influence of other factors of brute luck and, in particular, genetic endowments on the distribution of economic wealth. This article discusses three approaches that allow left-libertarians to take into account the factor of genetic luck in interpersonal distribution. First, it is Hillel Steiner’s proposal to attribute genetic information to natural resources, the benefits of which are subject to egalitarian redistribution. Second, it is the concept of equal opportunity for welfare by Peter Vallentyne, Michael Otsuka and Eric Roark. Third, it is the universal dominance criterion of Philippe Van Parijs and Kasper Ossenblok. The first two approaches face a number of moral and practical difficulties, but the third approach is able to overcome them. Thus, the universal dominance criterion is the most promising way to reconcile left-libertarianism and justice in the distribution of genetic endowments. (shrink)

This article critically examines one of the most prevalent metaphors in modern biology, namely the machine conception of the organism (MCO). Although the fundamental differences between organisms and machines make the MCO an inadequate metaphor for conceptualizing living systems, many biologists and philosophers continue to draw upon the MCO or tacitly accept it as the standard model of the organism. This paper analyses the specific difficulties that arise when the MCO is invoked in the study of development and evolution. In (...) developmental biology the MCO underlies a logically incoherent model of ontogeny, the genetic program, which serves to legitimate three problematic theses about development: genetic animism, neo-preformationism, and developmental computability. In evolutionary biology the MCO is responsible for grounding unwarranted theoretical appeals to the concept of design as well as to the interpretation of natural selection as an engineer, which promote a distorted understanding of the process and products of evolutionary change. Overall, it is argued that, despite its heuristic value, the MCO today is impeding rather than enabling further progress in our comprehension of living systems. (shrink)

In 1990 Robert Lickliter and Thomas Berry identified the phylogeny fallacy, an empirically untenable dichotomy between proximate and evolutionary causation, which locates proximate causes in the decoding of ‘ genetic programs’, and evolutionary causes in the historical events that shaped these programs. More recently, Lickliter and Hunter Honeycutt argued that Evolutionary Psychologists commit this fallacy, and they proposed an alternative research program for evolutionary psychology. For these authors the phylogeny fallacy is the proximate/evolutionary distinction itself, which they (...) argue constitutes a misunderstanding of development, and its role in the evolutionary process. In this article I argue that the phylogeny fallacy should be relocated to an error of reasoning that this causal framework sustains: the conflation of proximate and evolutionary explanation. Having identified this empirically neutral form of the phylogeny fallacy, I identify its mirror image, the ontogeny fallacy. Through the lens of these fallacies I attempt to solve several outstanding problems in the debate that ensued from Lickliter and Honeycutt’s provocative article. (shrink)

Developmental plasticity as the nexus between genetics and ecology.

The question of the holistic structure of an organism is a recurring theme in the philosophy of biology and has been increasingly discussed again in recent years. Organisms have recently been described as complex systems that autonomously create, maintain and reproduce themselves while constantly interacting with their environment. Key focal points include their autopoiesis, autonomy, agency and teleological structure. This perspective marks a significant advancement from the 20th-century viewpoint, which predominantly saw organisms as genetically programmed, randomly generated and blindly selected (...) survival-machines. However, crucial questions about the shape and development of organisms still lack answers. Shape and development are deeply interconnected and seem to require a holistic approach. Here, I will briefly outline a phenomenological perspective which could provide a framework for seeking answers to these fundamental questions. In particular, I propose a common four-fold phenomenal structure of the developing organism and the cognising consciousness, which makes it possible to observe the agential and teleological structure of the organism "from within". This fourfold structure also describes the molecular level and thus provides a general organismic concept. It furthermore corresponds to the four Aristotelian "causes" (conditions). (shrink)

To construct a synthetic cell we need to understand the rules that permit life. A central idea in modern biology is that in addition to the four entities making reality, matter, energy, space and time, a fifth one, information, plays a central role. As a consequence of this central importance of the management of information, the bacterial cell is organised as a Turing machine, where the machine, with its compartments defining an inside and an outside and its metabolism, reads and (...) expresses the genetic program carried by the genome. This highly abstract organisation is implemented using concrete objects and dynamics, and this is at the cost of repeated incompatibilities (frustration), which need to be sorted out by appropriate «patches». After describing the organisation of the genome into the paleome (sustaining and propagating life) and the cenome (permitting life in context), we describe some chemical hurdles that the cell as to cope with, ending with the specific case of the methionine salvage pathway. (shrink)

A formalism is introduced to represent the connective organization of an evolving neuronal network and the effects of environment on this organization by stabilization or degeneration of labile synapses associated with functioning. Learning, or the acquisition of an associative property, is related to a characteristic variability of the connective organization: the interaction of the environment with the genetic program is printed as a particular pattern of such organization through neuronal functioning. An application of the theory to the development of (...) the neuromuscular junction is proposed and the basic selective aspect of learning emphasized. (shrink)

In 1926, Haldane published an essay titled 'On Being the Right Size' in which he argued that the structure, function, and behavior of an organism are strongly conditioned by the physical forces that exert the greatest impact at the scale at which it exists. This chapter puts Haldane’s insight to work in the context of contemporary cell and molecular biology. Owing to their minuscule size, cells and molecules are subject to very different forces than macroscopic organisms. In a sense, macroscopic (...) and microscopic entities inhabit different “worlds”: the former is ruled by gravity and inertia, whereas the latter is governed by Brownian motion. One implication is that we should be extremely skeptical of models and analogies that seek to explain properties of microscopic entities by appealing to properties of macroscopic ones. Unfortunately, this is precisely what the appeal to engineering metaphors in molecular biology attempts to do. Molecular biologists routinely resort to such metaphors because they are familiar and intuitively intelligible. But if our machines were the size of molecules it would be impossible for them to function the way they do. It follows that we should avoid distorting biological reality by construing it in engineering terms. In this chapter I examine four key metaphors in molecular biology – “genetic program,” “cellular circuitry,” “molecular machine,” and “molecular motor” – and I argue that their deficiencies derive from their neglect of scale. I also try to explain why many biologists today appear to have forgotten the importance of scale that Haldane drew attention to in his essay. I suggest that the reason has to do with the influence of Schrödinger’s argument in 'What is Life?' regarding the stability of the gene. (shrink)

Life can be defined as combining two entities that rest on completely different physico-chemical properties and on a particular way of handling information. The cell, first, is a « machine », that combines elements which are quite similar (although in a fairly fuzzy way) to those involved in a man-made factory. The machine combines two processes. First, it requires explicit compartmentalisation, including scaffolding structures similar to that of the châssis of engineered machines. In addition, cells define clearly an inside, the (...) cytoplasm, and an outside. The cell envelope is more or less complicated in bacteria, and it is much more complicated in organisms made of cells with a nucleus (eukaryotes). Second, the machine also requires dynamic chemical processes, collectively named metabolism, that can be split into intermediary metabolism, managing chemical transformations and transport of small building blocks and management of energy (often with a rotating nanomachine, ATP synthase), and the macromolecule synthesis, salvage and turnover machinery which uses a variety of nanomachines, the ribosome being the most prominent one. The second entity which needs to be associated to life is the genetic program, in the form of the genome, composed of one or several chromosomes made of DNA. This is the entity which associates most clearly to information. -/- Natural selection uses information in a particular way: it is a process that uses energy to prevent degradation of any functional entity. This process keeps building up novel information within organisms. (shrink)

A major flaw of the book is its failure to note Wittgenstein’s role in destroying the mechanical or reductionist or computationalist view of mind. These continue to dominate cognitive science and philosophy in spite of the fact that they were powerfully countered by W and later by Searle and others. -/- There is much talk of W’s use of terms like “grammar”, “rules” etc but never a clear mention that they mean our Evolved Psychology or our genetically programmed innate behavior. (...) There are references to Baker and Hacker's works and to Budd, but none to many standard W refs such as ter Hark, Johnston, and especially to the searchable Intelex CDROM of his complete works, nor to Searle, and none to the vast literature of EP. -/- Many sections of the book are reasonably successful in describing W’s work but there is much aimless wandering and many mistakes and confusions. These will hopefully be obvious to those who read the above and my other reviews as I cannot recount more than a few of the hundreds of critical comments I made in my two readings of this book. A major flaw, common to most writing in the behavioral sciences, is the lack of awareness of the S1/S2 two selves mode of describing personality that W pioneered (though nobody noticed) and a failure to be clear about nature/nuture issues. The fast automatic perceptions, ‘rules’ and behaviors of S1 are mushed together with the slow conscious dispositional thinking, believing and rule following of S2 and neither are clearly or consistently distinguished from the arbitrary cultural behaviors of S3. -/- I wrote this review several years ago and since then my ideas have evolved considerably. Eventually I may revise this but for now the interested reader may consult my many more recent reviews and articles, especially “ The Logical Structure of Philosophy, Psychology, Mind and Language as Revealed in Wittgenstein and Searle” 80p (2016). Briefly, I now see that virtually all authors failed to give Wittgenstein’s last work “On Certainty” the prominent position it deserves and likewise failed to take advantage of the powerful dual systems of thought framework. Nor have they adopted the useful extensions of Wittgenstein’s work made by John Searle. So I first lay out a framework and then provide some detailed comments. -/- This is a reasonable first attempt to bring W’s pioneering work on higher order thought to the attention of psychology but it has many failings and needs a thorough rewrite. -/- Those wishing a comprehensive up to date framework for human behavior from the modern two systems view may consult my book ‘The Logical Structure of Philosophy, Psychology, Mind and Language in Ludwig Wittgenstein and John Searle’ 2nd ed (2019). Those interested in more of my writings may see ‘Talking Monkeys--Philosophy, Psychology, Science, Religion and Politics on a Doomed Planet--Articles and Reviews 2006-2019 3rd ed (2019), The Logical Structure of Human Behavior (2019), and Suicidal Utopian Delusions in the 21st Century 4th ed (2019). (shrink)

Habermas's collection of essays "The Future of Human Nature" is of particular interest for two sorts of reasons. For those interested in bioethics, it contains a genuinely new set of arguments for placing serious restrictions on using prenatal genetic technologies to “enhance” offspring. And for those interested in Habermas’s moral philosophy, it contains a number of new developments in his “discourse ethics”—not the least of which is a willingness to engage in applied ethics at all. -/- The real key (...) to Habermas’s argument is that human personhood and moral agency presuppose certain modes of relating to oneself that are threatened by the asymmetrical way in which genetic enhancements would presumably work. Thus, instead of taking up and then extending familiar normative concerns about unequal opportunities or the criteria for moral personhood, Habermas believes that the emerging technologies of genetic enhancement demand genuinely new arguments, and he proposes to focus on the effects of genetic programming on whether the agent can consider herself free and equal—effects, that is, regarding what one might call the reflexive attitudinal preconditions for moral agency. -/- Like contractarians and Kantians more generally, Habermas faces difficulties accommodating the intuition that we might have obligations toward potential persons. The difficulty is particularly pronounced in the case of Habermas’s “discourse theory of morality,” since it construes the moral point of view in terms of processes of deliberation among all those affected by the norm at issue which the participants consider in the deliberative process to be open, fair, and inclusive. Future generations do not fit neatly into this deliberative process, nor do prepersonal humans. Moral norms adjudicated in such discourse clearly affect their interests, but they cannot themselves participate in the discourse. In the past, Habermas and other “discourse ethicists” have tried to address this worry by introducing “advocatory discourses.” But this move threatens to undo a distinctive, appealing feature of Habermas’s moral theory: the pragmatist insistence on the innovative, critical, unpredictable discourse generated by actual participants in discourse and the refusal (contra Rawls, in particular) to rely on hypothetical representatives. -/- In The Future of Human Nature, Habermas ventures a different strategy,focused on expanding what he calls the “ethical” domain, which differs from the “moral” domain in being a matter of a community’s articulation of its core values and conception of the good. Previously, Habermas distinguished “ethical-existential” and “ethical-political” domains, as a matter of who an individual or a community, respectively, is and wants to be. In the present book, Habermas makes the remarkable move of introducing the category of the “species-ethical,” which is supposed to be the domain of questions raised by the human species as a whole about the question of what it is to be human. This theoretical move extends further steps Habermas had already taken in speaking of ethical solidarity within the global community. -/- . (shrink)

This academic paper provides a historical reflection on the problem of the origin of science in order to determine the reasons for differences in determining the date and content of the first scientific achievements. The application of historical-genetic research methods in the disciplinary aspect contributes to the distinction of particular scientific programs in the science body frame with a different relationship between the object and subject of cognition, the internal logic of ideas and worldviews. As a result, the (...) existing research concerned with the conditions of knowledge function in different types of society or with the relations between the structure of knowledge and its purpose, was supplemented by an explication of forms of the continuity of program components – ontological, epistemological and axiological basis of specific scientific cognition/knowledge. In particular, it is established that the ancient world atomistic and peripatetic programs follow the structural pattern of the scientific explanation of the Pythagorean one (scientific and philosophical at the same time), contributing a new subject content in it. (shrink)

Richard Dawkins has popularized an argument that he thinks sound for showing that there is almost certainly no God. It rests on the assumptions (1) that complex and statistically improbable things are more difficult to explain than those that are not and (2) that an explanatory mechanism must show how this complexity can be built up from simpler means. But what justifies claims about the designer’s own complexity? One comes to a different understanding of order and of simplicity when one (...) considers the psychological counterpart of information. In assessing his treatment of biological organisms as either self-programmed machines or algorithms, I show how self-generated organized complexity does not fit well with our knowledge of abduction and of information theory as applied to genetics. I also review some philosophical proposals for explaining how the complexity of the world could be externally controlled if one wanted to uphold a traditional understanding of divine simplicity. (shrink)

In this paper I piece present an account of Husserl’s approach to the phenomenological reconstruction of consciousness’ immemorial past, a problem, I suggest, that is quite pertinent for defenders of Lockean psychological continuity views of personal identity. To begin, I sketch the background of the problem facing the very project of a genetic phenomenology, within which the reconstructive analysis is situated. While the young Husserl took genetic matters to be irrelevant to the main task of phenomenology, he would (...) later come to see their importance and, indeed, centrality as the precursor and subsoil for the rationality of consciousness. I then argue that there is a close connection between reconstruction and genetic phenomenology, such that reconstruction is a necessary component of the program of genetic phenomenology, and I set out an argument of Husserl’s compelling one to enter into reconstructive territory. With that impetus, I schematically lay out the main contours one finds in Husserl’s practice of reconstructive techniques. We find him taking two distinct approaches, that of the individual viewed egologically (through the abstract lens of a single individual’s consciousness) and as embedded in interpersonal relations. Husserl occasionally calls these the approach “from within” and “from without,” respectively. Ultimately, the two approaches are not only complementary, but require one another. In closing, I argue that these considerations lead to a blurring of lines between the genetic and generative phenomenological registers, which challenges the prevalent view that there is a sharp demarcation of the two. (shrink)

A remarkable event occurred at the December 3, 2004, meeting of the U. S. President’s Council on Bioethics. Council member William Hurlbut, a physician and Consulting Professor in the Program in Human Biology at Stanford University, formally unveiled a proposal that he claimed would solve the ethical problems surrounding the extraction of stem cells from human embryos. The proposal would involve the creation of genetically defective embryos that “never rise to the level of integrated organismal existence essential to be designated (...) human life with potential,” and therefore could be used as morally acceptable sources of stem cells for research and therapy. The aim of this essay is to show that Hurlbut’s proposal does not solve the ethical problems associated with human embryonic stem cell research. Two major reasons are presented. First, the proposal, which involves modification of a somatic cell nucleus, suffers from an ethical problem that is common to all types of human genetic engineering: since the procedure is not foolproof, there will be failures. In the case of the procedure Hurlbut proposes, some normal (albeit cloned) embryos will be produced. Second, the embryo engineered in the manner described is, at least in the early stages of its development, fully human despite its genetic defect. This essay also will show how a reasonable person might mistakenly view the proposal as legitimate if he or she makes the error of conflating genetic determinism with Aristotelian teleology. Finally, it will argue that ethical clarity can be achieved by seeing the embryo as a holistic entity possessing emergent properties that cannot simply be spelled out by genes. (shrink)

The rediscovery of Mendel's laws a century ago launched the science that William Bateson called "genetics," and led to a new view of evolution combining selection, particulate inheritance, and the newly characterized phenomenon of "mutation." This "mutationist" view clashed with the earlier view of Darwin, and the later "Modern Synthesis," by allowing discontinuity, and by recognizing mutation (or more properly, mutation-and-altered-development) as a source of creativity, direction, and initiative. By the mid-20th century, the opposing Modern Synthesis view was a prevailing (...) orthodoxy: under its influence, "evolution" was redefined as "shifting gene frequencies," that is, the sorting out of pre-existing variation without new mutations; and the notion that mutation-and-altered-development can exert a predictable influence on the course of evolutionary change was seen as heretical. Nevertheless, mutationist ideas re-surfaced: the notion of mutational determinants of directionality emerged in molecular evolution by 1962, followed in the 1980s by an interest among evolutionary developmental biologists in a shaping or creative role of developmental propensities of variation, and more recently, a recognition by theoretical evolutionary geneticists of the importance of discontinuity and of new mutations in adaptive dynamics. The synthetic challenge presented by these innovations is to integrate mutation-and-altered-development into a new understanding of the dual causation of evolutionary change--a broader and more predictive understanding that already can lay claim to important empirical and theoretical results--and to develop a research program appropriately emphasizing the emergence of variation as a cause of propensities of evolutionary change. (shrink)

A recent study by Castellani et al. (JAMA 302(23):2573–2579, 2009) describes the population-level effects of the choices of individuals who underwent molecular carrier screening for cystic fibrosis (CF) in Veneto, in the northeastern part of Italy, between 1993 and 2007. We discuss some of the ethical issues raised by the policies and individual choices that are the subject of this study. In particular, (1) we discuss the ethical issues raised by the acquisition of genetic information through antenatal carrier testing; (...) (2) we consider whether by choosing to procreate naturally these couples can harm the resulting child and/or other members of society, and what the moral implications of such harm would be; (3) we consider whether by choosing to avoid natural procreation carrier couples can harm current or future individuals affected by cystic fibrosis; (4) we discuss whether programs that make carrier testing available can be considered eugenic programs. (shrink)

The genealogy-based classificatory programs of Kant and Darwin are briefly discussed for context. It is detailed how in biology there is no unambiguous term to reference infraspecific-level descent-based divisions. The term lineage population is introduced and defined for analytic purposes as one of a set of inter-fertile divisions of organisms into which members are arranged by propinquity of descent. It is argued that the lineage population concept avoids the ambiguities associated with related biological and anthropological concepts and polysemes such (...) as population, ethnicity, and race. Other terms and concepts, such as form, cline, cluster, geographic population, breeding population, genetic population, breed, species, subspecies, ancestry, geographic ancestry, biogeographic ancestry, ancestral population, ancestry population, natural division, and population lineage, are discussed in relation to this concept. It is concluded that the lineage population concept is a useful analytic tool which describes, in line with the Kantian/Darwinian perspective, an interesting class of biological variation. (shrink)

The scientific study of living organisms is permeated by machine and design metaphors. Genes are thought of as the ‘‘blueprint’’ of an organism, organisms are ‘‘reverse engineered’’ to discover their func- tionality, and living cells are compared to biochemical factories, complete with assembly lines, transport systems, messenger circuits, etc. Although the notion of design is indispensable to think about adapta- tions, and engineering analogies have considerable heuristic value (e.g., optimality assumptions), we argue they are limited in several important respects. In (...) particular, the analogy with human-made machines falters when we move down to the level of molecular biology and genetics. Living organisms are far more messy and less transparent than human-made machines. Notoriously, evolution is an oppor- tunistic tinkerer, blindly stumbling on ‘‘designs’’ that no sensible engineer would come up with. Despite impressive technological innovation, the prospect of artificially designing new life forms from scratch has proven more difficult than the superficial analogy with ‘‘programming’’ the right ‘‘software’’ would sug- gest. The idea of applying straightforward engineering approaches to living systems and their genomes— isolating functional components, designing new parts from scratch, recombining and assembling them into novel life forms—pushes the analogy with human artifacts beyond its limits. In the absence of a one-to-one correspondence between genotype and phenotype, there is no straightforward way to imple- ment novel biological functions and design new life forms. Both the developmental complexity of gene expression and the multifarious interactions of genes and environments are serious obstacles for ‘‘engi- neering’’ a particular phenotype. The problem of reverse-engineering a desired phenotype to its genetic ‘‘instructions’’ is probably intractable for any but the most simple phenotypes. Recent developments in the field of bio-engineering and synthetic biology reflect these limitations. Instead of genetically engi- neering a desired trait from scratch, as the machine/engineering metaphor promises, researchers are making greater strides by co-opting natural selection to ‘‘search’’ for a suitable genotype, or by borrowing and recombining genetic material from extant life forms. (shrink)

Originally applied on domestic and lab animals, assisted reproduction technologies (ARTs) have also found application in conservation breeding programs, where they can make the genetic management of populations more efficient, and increase the number of individuals per generation. However, their application in wildlife conservation opens up new ethical scenarios that have not yet been fully explored. This study presents a frame for the ethical analysis of the application of ART procedures in conservation based on the Ethical Matrix (EM), (...) and discusses a specific case study—ovum pick-up (OPU) procedures performed in the current conservation efforts for the northern white rhinoceros (Ceratotherium simum cottoni)—providing a template for the assessment of ART procedures in projects involving other endangered species. (shrink)

Why interdisciplinary research in AI is so important, according to Jurassic Park. -/- “Your scientists were so preoccupied with whether or not they could, they didn’t stop to think if they should.” -/- I think this quote resonates with us now more than ever, especially in the world of technological development. The writers of Jurassic Park were years ahead of their time with this powerful quote. -/- As we build new technology, and we push on to see what can actually (...) be achieved there is an undertone of sales to whatever we build. The end product must be sold somewhere and to someone. This can derail any good intentions, just as building a resort full of dinosaurs was sold as a fun attraction, we see later in the film that it became a resort of terror. -/- In the field of AI we are certainly late to the party with ethics and regulation. Indeed, even existing modelling protocols have been, in many cases, circumvented or potentially ignored. This has led to a widening of the gap in the interdisciplinary field of AI. This is compounded by pop culture representations of AI and the Ethicist’s potential lack of knowledge surrounding technical progression in the field of AI. There are now seemingly two separate branches that ought to be in sync. The first branch is a group of Philosophers led by the Author of Superintelligence, Nick Bostrom, who believe that there is a singularity where AI takes over the world and starts to kill off humans. The second branch is the Technical Cohort who are led by companies such as Google and Deepmind. The remit of these developers is to see what can be developed and produced. Ultimately a separate sales team will determine what products can be sold. -/- We have seen multiple failures of AI due to lack of interdisciplinary discourse. Some cases include misallocated or cut off financial support and healthcare. This indicates the prevalence of issues that can grow and become ever more complex. -/- So, we have to ask ourselves two questions: One, do the Philosophers have a point? Two, does that point refer to humans programming AI in such a way that the destruction of the human race is its optimal aim in order to create a better future world? -/- Is the development of AI that different to an island of genetically engineered Dinosaurs? -/- The only solution, in my view, is interdisciplinary discourse. (shrink)

[Filip Tvrdý on Naturalizing Philosophy] The paper distinguishes several versions of contemporary naturalism: revisionary, constructive, and non-representational. Revisionary naturalism pleads substituting the traditional philosophical inquiry into the nature of things by a genetic inquiry into the origin of our – often faulty – beliefs about the nature of things. Constructive naturalism accepts the program of traditional philosophy, yet hoping that its questions could be answered by broadly scientific methods. Non-representational naturalism is an extension of metaethical expressivism, claiming that philosophical (...) claims should not be understood as descriptive in nature. These distinctions can help us classify the most self-consciously naturalistic project in the recent Czech philosophy, Filip Tvrdý’s TROUBLES OF INTROSPECTION (2015). Tvrdý is officially pursuing a genetic, revisionary project, which does not coincide with nonrepresentational naturalism. However, there are also traces of constructive naturalism in Tvrdý’s book. (shrink)

Întrebarea de bază este, ce este o pseudoştiinţă? Una din cele mai disputate delimitări ale ştiinţei. Mulţi savanţi de renume mondial, unanim recunoscuţi (ca de ex. Charles Darwin) au cochetat de-a lungul timpului cu diverse aspecte ale pseudoştiinţei considerându-le, cu bună credinţă, drept ştiinţă. Şi multe domenii ale pseudoştiinţei actuale au fost, la vremea lor, considerate drept domenii onorabile ale ştiinţei. Chiar şi în prezent, practicanţii pseudoştiinţelor nu recunosc valabilitatea etichetei puse domeniului lor de activitate. Oamenii de ştiinţă au tendinţa (...) să claseze pe loc un domeniu de activitate, în funcţie de cunoştinţele şi cultura lor, drept ştiinţă sau pseudoştiinţă. Dar graniţa dintre ştiinţă şi pseudoştiinţă este în multe cazuri foarte vagă. Într-un fel, această problemă seamănă cu problema filozofică a stabilirii a ce e bine şi ce e rău. Filosofii ştiinţei, cum ar fi Paul Feyerabend, au susţinut că nu este nici posibil, nici de dorit, o distincţie între ştiinţă şi non-ştiinţă. Printre problemele care pot face distincţia dificilă este viteza variabilă de evoluţie între teoriile şi metodologiile ştiinţei ca răspuns la noile date. În plus, standardele specifice aplicabile unui domeniu al ştiinţei ar putea să nu fie aplicabile în alte domenii. După cum se spune în diferite cursuri despre introducerea în ştiinţe, pseudoştiinţa este oricare subiect care pare a fi ştiinţific la prima vedere, sau ai cărui susţinători susţin că este ştiinţific, dar care contravine condiţiilor de testare sau deviază mult de la alte aspecte fundamentale ale metodelor ştiinţifice. Pseudoştiinţa este caracterizată de folosirea unor afirmaţii vagi, exagerate sau care nu se pot testa, supralicitarea confirmării în detrimentul argumentării, lipsa transparenţei pentru teste realizate de alţi experţi, şi o stagnare în dezvoltarea teoriei. CUPRINS: Pseudoştiinţa - Ştiinţa şi pseudoştiinţa - - Metodologie ştiinţifică - - Falsificabilitatea - - Normele Merton - - Refuzul de a recunoaşte problemele - - Critica termenului - Identificarea pseudoştiinţei - Ştiinţa patologică - - Exemplele lui Langmuir - - - Raze N - - - Exemple ulterioare - - Exemple mai noi - - - Poliapa - - - Fuziunea la rece - - - Memoria apei - Antropomorfism - - În preistorie - - În religie şi mitologie - - - Critici - - În ştiinţă - - - Antonim - Criptozoologia - - Referinţe - - Critici - Pseudomatematica - - Unele taxonomii ale pseudomatematicii - - - Încercările de rezolvare a problemelor clasice imposibil de rezolvat - - Practicanţii - - Un exemplu ilustrativ - Radiestezia - - Originea radiesteziei - - Dispozitivele de detecţie - - - Anse - - Evaluarea ştiinţifică a radiesteziei - - - Studiul Kassel - - - Studiu Betz - - - Explicaţii sugerate - Scientologia - - Credinţe - - - Puntea Libertăţii Totale - - - Morala şi etica - - - Triunghiurile ARC şi KRC - - - Viaţa de apoi - - - Dumnezeu - - - Ştiinţa - - Învăţături şi practici - - - Terminologie - - - Interpretare şi context - - - Învăţarea treptată - - - Audit - - - Organismul - - - Naşterea silenţioasă - - - Sărbători - Sincronicitatea - - Principiul - - Exemplu - - Relaţia cu cauzalitatea - - Critici - Programarea neuro-lingvistică - - Tehnici sau set de practici - - Aplicaţii - - - Psihoterapie - - - Alte utilizări - - NLP ca o cvasi-religie - Manipularea şi automanipularea prin cuvinte - - Aflaţi când şi unde se folosesc cuvintele - - Testaţi pentru a vedea cum reacţionaţi la cuvinte - - Controlul sau manipularea prin cuvinte - - Uitaţi-vă la nivelul cuvintelor - - Vedeţi cum vă pot ajuta cuvintele, făcându-se nu doar utile, ci şi frumoase - - Exploraţi lumea mentală a cuvintelor - - - Încercaţi să exploraţi lumea fără cuvinte - - Priviţi din nou totul, pentru prima dată fără cuvinte Pseudofizica - Anti-gravitaţia - - Efecte convenţionale care imită efectele anti-gravitaţiei - - Soluţii ipotetice - - - Scuturi gravitaţionale - - - Cercetări în relativitatea generală în anii 1950 - - - A cincea forţă - - - "Unităţi distorsionate" în relativitatea generală - - - Breakthrough Propulsion Physics Program - - Încercări experimentale şi comerciale - - - Dispozitive giroscopice - - - Gravitatorul lui Thomas Townsend Brown - - - Cuplarea gravitoelectrică - - - Premiul Göde - Energia orgonică - - Dezvoltarea de către Reich a teoriilor sale orgonice - - Cărţile lui Reich - - Evaluarea teoriei - Eter luminifer - - Dezavantaje şi critici - Fuziunea la rece - - Fuziunea cu bule - - Rezultate - - - Producţia de energie şi căldura în exces - - - Heliu, elemente grele, şi neutroni - - Mecanisme propuse - Planete ipotetice: X / Nibiru - - Teorii ale conspiraţiei - - Reacţii publice - - Influenţa culturală - Poliapa (Apa polimerizată) - Maşini alimentate cu apă - - Ce nu sunt maşini alimentate cu apă - - Extragerea energiei din apă - - Hidrogenul ca supliment - - Pilula de benzină şi aditivi Pseudoarheologia - Caracteristici - - Lipsa metodei ştiinţifice - - Opoziţia la regulile arheologice - - Motivaţii naţionaliste - - Motivaţii religioase - Rasele de bază - - Rase de bază, epoci şi subrase - - - Prima rasă de bază (eterică) - - - A doua rasă de bază (hiperboreană) - - - A treia rasă de bază (lemuriană) - - - A patra rasă de bază (atlantidă) - - - A cincea rasă de bază (ariană) - - - A şasea rasă de bază - - - A şaptea rasă de bază - - Migrarea spre Mercur - - Credinţa teosofică în fraternitatea umanităţii - Protocronism - - Istoria protocronismului - - Scrierea dacică - Pământul gol (Intratereştrii) - - Ipoteza Pământului gol concav - Fenomenul 2012 - - Tortuguero - - Chilam Balam - Creaţia inteligentă - - Concepte - - - Complexitatea ireductibilă - - - Complexitatea specifică - - - Universul bine pus la punct - - - Creatorul inteligent - - Mişcarea creaţia inteligentă - - - Religia şi susţinătorii importanţi - Creaţionismul ştiinţific - - Abordări ale ştiinţei creaţiei - - - Religia - - - Afilieri religioase moderne - - - Abordări ştiinţifice - - Critici - - - Ipoteze metafizice - - - Critici religioase - - - Critici ştiinţifice - - - Critici istorice, filozofice, şi sociologice - - Domenii de studiu - - - Biologia creaţionistă - - - Ştiinţele Pământului şi Geofizica - - - Astronomia şi cosmologia - Ufologia - - Statutul ca disciplină ştiinţifică - - - Pseudoştiinţă - - - Aspecte metodologice - Teoria astronautului extraterestru - - Argumente şi susţinători - - Erich von Däniken - - Ipoteza creaţiei - - - Argumentul genetic - - - Cercetarea genetică şi evoluţia creierului Medicina alternativă - Tipuri de medicină alternativă - - Sisteme bazate pe convingeri neştiinţifice sau practici tradiţionale - - Energii supranaturale şi interpretări eronate ale energiilor fizice - Ayurveda - Homeopatia - - Remedii şi tratamente - - - Pregătirea - - - Diluţii - - - Patogeneza - - Reglementări şi prevalenţe - - Opoziţia publică - Medicina energetică - - Clasificarea metodelor - - Convingeri - - Cercetări ştiinţifice - - - Vindecarea la distanţă - - - Vindecarea prin contact - - - Baza de date - - Explicaţii alternative pentru rapoarte pozitive - Reiki - - Practica - - - Vindecarea - - - Tratamentul întregului organism - - - Tratament localizat - - - Respiraţia - - - Trei piloni de bază - Terapia de conversie - Metoda Bates pentru îmbunătăţirea vederii - - Concepte - - - Acomodarea - - - Cauze ale problemelor de vedere - Detoxifierea - - Detoxifierea în medicina alternativă - - - Istoric - - - Tampoane de curăţare şi detoxifiere - - Tipuri de detoxifiere - - - Dezintoxicarea de alcool - - - Dezintoxicarea de droguri - - - Detoxifiere metabolică - - - Medicina alternativă - - Modalităţi de detoxifiere - - - Diete de detoxifiere - - - Curăţirea colonului - - - Metale grele - - - Dispozitive de detoxifiere - - Terapia de chelare - - - Detoxifierea proteică - - Detoxifierea anusului şi intestinelor cu cafea - - - Efecte şi riscuri - - Plasturi (tampoane) de detoxifiere aplicate pe picioare - - - Ce sunt plasturii de detoxifiere (tampoanele de detoxifiere) pentru picior? - - - De ce se aplică plasturii pe picioare? - Fizionomia - - Origini moderne - - Perioada de popularitate - - Ştiinţa modernă - - Utilizarea modernă - Frenologia Paranormal - Activităţi paranormale - - Fantome şi alte entităţi spirituale - - Viaţa extraterestră şi OZN-urile - - Criptide - Cercetări în paranormal - - Abordări anecdotice - - Abordarea observaţiilor participanţilor - - Anomalistica - - Neuroştiinţa - - Critici - Vitalism - - Filozofia - - Ştiinţa - - - Relaţia cu emergentismul - - Mesmerism - - Medicina complementară şi alternativă - Aura - - Tradiţii spirituale - - Teste - - Explicaţii - Profeţii - - Definiţii - - Civilizaţii antice - - Credinţa Bahá'í - - Budism - - China - Religiile abrahamice - - Iudaism - - - She'ol - Experienţe aproape de moarte - - Caracteristici - Viaţa de Apoi (Viaţa de după moarte) - - Filozofia vieţii de Apoi - - - Filozofia modernă - - - Filozofia procesului - - Ştiinţa despre viaţa de Apoi - Modele metafizice ale Vieţii de Apoi - - Reîncarnarea - - Raiul şi iadul - - Limbo - - Purgatoriul - Nemurirea - - Abordări ştiinţifice - - Abordări religioase - - Nemurirea biologică - - - Specii biologice nemuritoare - - - Evoluţia îmbătrânirii - - Speranţe privind nemurirea biologică umană - - - Substanţe care prelungesc durata de viaţă - - - Nemurirea tehnologică - - - Crionica - - - Încărcarea minţii la calculator - - - Cibernetica - - - Nemurirea evoluţionară - Strigoi - Fantome - - Tipologia - - - Context antropologic - - Fantomele şi viaţa de apoi - - Teama de fantome - - Atribute comune - - Locaţii - Locaţii paranormale - România - - Judeţul Bacău - - - Conacul Zarifopol, în Filipeşti - - Bucureşti - - - Mănăstirea Chiajna - - - Hotel Cişmigiu - - - "Casa Diavolului", pe strada General Praporgescu - - - Orfelinatul pe strada Franceză - - - Casa Vernescu pe Calea Victoriei - - - Iazul Vrăjitoarelor - - Judeţul Călăraşi - - - Pădurea Călugăreasa - - Judeţul Cluj - - - Castelul Bánffy - - - Pădurea Hoia - - Judeţul Dâmboviţa - - - Trinitatea Miresei pe DN7 - - Judeţul Dolj - - - Pădurea Radovan - - Judeţul Iaşi - - - Casa Gavril Buzatu pe Manta Roşie - - - Dealul Lunganilor - - Judeţul Maramureş - - - Drumul European E58 lângă Cicărlău Parapsihologia - Terminologie - Cercetări - - Domenii - - Metodologie - - Cercetări experimentale - Percepţiile extrasenzoriale - - Investigarea parapsihologică - - Percepţiile extrasenzoriale şi hipnoza - Psihochinezia (telechinezia) - - Credinţa - - - Subdomenii ale telechineziei - - - Aptitudini notabile ale capabilităţilor psihocinetice Ezoterism - Etimologie - Cosmologia ezoterică - - Gnosticism - - Cabala - - Neoplatonism - - Teosofia şi antroposofia - - Max Theon şi "filosofia cosmică" - Ocultism - - Ştiinţă şi ocultism - - - Calităţi oculte - Magia - - Caracteristici comune în practica magiei - - - Ritualuri - - - Simboluri magice - - - Limbajul magiei - - - Magicieni - - - Vrăjitoria - - Teorii - - - Origini antropologice şi psihologice - Clarviziunea - - Aspecte ale clarviziunii - - Vizualizarea de la distanţă - Geomanţia - Tarot - - Arcana mare şi arcana mică - - Utilizare - - - Cărţi inversate - - - Desfăşurări - Masoneria - - Istoria masoneriei - - Loja masonică - - Structura masoneriilor - - - Recunoaşterea masonică reciprocă - Taoism - - Categorisire - - Ceaiul şi taoismul - - Credinţe taoiste - - Principii - - - Tao - - - De (Te) - - - Wu wei - - - Pu - - Spiritualitatea - - Escatologia Astrologia - Principii şi practici - - Astrologia occidentală - - Astrologia hindusă - - Astrologia chineză şi din Asia de Est - Astrologia şi ştiinţa - - Delimitarea - Astrohărţi - Principiile de bază ale astrologiei - - Modele astrologice - - Astrologia predictivă - Tradiţii în astrologie - - Tradiţii istorice - - Tradiţii ezoterice - Horoscop - - Etimologie - - Concepte în astrologia occidentală - - - Unghiuri - - - Zodiacul - - - Case - - Construcţia unui horoscop în astrologia occidentală - - - Case - - - Plasamente ale planetelor - - - Aspecte - - - Ascendentul - - Horoscopul chinez - Bioritm - - Teoria - - Calculul - - Plauzibilitate Vrăjitoria - Definiţii - Practici invocate de vrăjitoare - - Descântece - - Invocarea morţii - Vrăjitoarele bune - Demonologia Referinţe Despre autor - Nicolae Sfetcu - - De același autor - - Contact Editura - MultiMedia Publishing . 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The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

In this chapter, I describe my “post-diagnosis” experiences as the parent of an autistic child, those years in which I tried, but failed, to make sense of the overwhelming and often nonsensical information I received about autism. I argue that immediately after being given an autism diagnosis, parents are pressured into making what amounts to a life-long commitment to a therapy program that (they are told) will not only dramatically change their child, but their family’s financial situation and even their (...) entire mode of existence. Moreover, despite information overload, many treatment programs for autism rely on empty jargon and make completely unrealistic promises, so parents are left feeling overwhelmed and panicked. Even well respected therapy programs encourage parents to spend liberally. Indeed, autistic therapists, who help construct what I refer to as the Culture of Autism, advise parents to commit to a minimum of 35 to 45 hours of intensive therapy every week. The implications are clear: for a parent who works full-time, their autistic child becomes a second full-time job. Autism is big business right now, and therapists are pushing parents to the brink of desperation. So it is not too surprising that there is a desperate cry for a more permanent solution—which is why researchers seek to cure autism. But there are two ways to conceptualize cure. A Therapeutic Cure model (TC) conceives of a cure as a beneficial treatment for the patient that eliminates or ameliorates the harms of the disease or condition. But the notion of a therapeutic cure for autism is highly implausible, given the complexities of autism. Indeed, at this point, the vast majority of researchers have come to the conclusion that the idea of a therapeutic cure for autism is simply a non-starter. Therefore the bulk of research seeking a cure for autism focuses instead on a second approach, which I refer to as the Negative Eugenics Cure model (NEC). With this model, the intention is to eliminate the disease or condition without regard for the health or well-being of the organism carrying the disease or condition. So, with regard to autism, researchers are focusing on identifying genetic markers for autism that can be detected in utero, or in embryos, so that autistic fetuses can be eliminated and autism eradicated by preventing the existence of autistic individuals. I review both models and argue that both fail to provide convincing arguments that the “solution” either offers is desirable. Both rest on the assumption that autism renders a life not worth living which, all things considered, is false. Instead of pushing to cure autism, an idea pervasive in this Culture of Autism, I contend that autistics are individuals with lives worth living. Moreover, rather than expend millions on research to search for the means to eliminate autism, we should instead expend our resources to ensure autistic individuals have access to support they may need. If the phenomenology of autism were better understood and appreciated, the panicked demand for a cure for autism might abate and perhaps autism could be seen as having value in and of its own right. (shrink)

I want to exhibit the deeper metaphysical reasons why some common ways of describing the causal role of genes in development and evolution are problematic. Specifically, I show why using the concept of information in an intentional sense in genetics is inappropriate, even given a naturalistic account of intentionality. Furthermore, I argue that descriptions that use notions such as programming, directing or orchestrating are problematic not for empirical reasons, but because they are not strictly causal. They are intentional. By contrast, (...) other notions that are part of the received view in genetics and evolutionary theory are defensible if understood correctly, in particular the idea that genes are the main replicators in evolution. The paper concludes that dropping all intentional or intentionally laden concepts does not force us to accept the so-called causal parity thesis, at least not in its stronger form. (shrink)

The first objective of the paper is to propose a classification and characterize the major approaches to the modes of cultural evolution: (1) Research programs on the origins of the cultural capacity of the human species. (2) Description and explanation of cultural change with the help of concepts or models inspired by the schemes of population genetics. (3) Research on parallel evolution of genes and culture. (4) Narrow coupling between biological evolution and cultural evolution, or the “gene-culture coevolution paradigm.” (...) These four modes of cultural evolution make sense at a different time-scale (respectively: more than 100 000 years; less than 100 years; greater than 1000 years; less than 1000 years). The second section of the paper provides an evaluation of the various programs, from various points of view: methodological, ethical, and epistemological. (shrink)

In The Future of Human Nature, Jürgen Habermas raises the question of whether the embryonic genetic diagnosis and genetic modification threatens the foundations of the species ethics that underlies current understandings of morality. While morality, in the normative sense, is based on moral interactions enabling communicative action, justification, and reciprocal respect, the reification involved in the new technologies may preclude individuals to uphold a sense of the undisposability of human life and the inviolability of human beings that is (...) necessary for their own identity as well as for reciprocal relations. Engaging with liberal bioethics and Catholic approaches to bioethics, the article clarifies how Habermas’ position offers a radical critique of liberal autonomy while maintaining its postmetaphysical stance. The essay argues that Habermas’ approach may guide the question of rights of future generations regarding germline gene editing. But it calls for a different turn in the conversation between philosophy and theology, namely one that emphasizes the necessary attention to rights violations and injustices as a common, postmetaphysical starting point for critical theory and critical theology alike. In 2001, Jürgen Habermas published a short book on questions of biomedicine that took many by surprise.[1] To some of his students, the turn to a substantive position invoking the need to comment on a species ethics rather than outlining a public moral framework was seen as the departure from the “path of deontological virtue,”[2] and at the same time a departure from postmetaphysical reason. Habermas’ motivation to address the developments in biomedicine had certainly been sparked by the intense debate in Germany, the European Union, and internationally on human cloning, pre-implantation genetic diagnosis, embryonic stem cell research, and human enhancement. He turned to a strand of critical theory that had been pushed to the background by the younger Frankfurt School in favor of cultural theory and social critique, even though it had been an important element of its initial working programs. The relationship of instrumental reason and critical theory, examined, among others, by Max Horkheimer, Theodor W. Adorno, and Herbert Marcuse and taken up in Habermas’ own Knowledge and Interest and Theory of Communicative Action became ever-more actual with the development of the life sciences, human genome analysis, and genetic engineering of human offspring. Today, some of the fictional scenarios discussed at the end of the last century as “science fiction” have become reality: in 2018, the first “germline gene-edited” children were born in China.[3] Furthermore, the UK’s permission to create so-called “three-parent” children may create a legal and political pathway to hereditary germline interventions summarized under the name of “gene editing.”In this article, I want to explore Habermas’ “substantial” argument in the hope that philosophy and theology become allies in their struggle against an ever-more reifying lifeworld, which may create a “moral void” that would, at least from today’s perspective, be “unbearable”, and for upholding the conditions of human dignity, freedom, and justice. I will contextualize Habermas’ concerns in the broader discourse of bioethics, because only by doing this, his concerns are rescued from some misinterpretations.[1] Jürgen Habermas, The Future of Human Nature.[2] Ibid., 125, fn. 58. 8[3] Up to the present, no scientific publication of the exact procedure exists, but it is known that the scientist, Jiankui He, circumvented the existing national regulatory framework and may have misled the prospective parents about existing alternatives and the unprecedented nature of his conduct. Yuanwu Ma, Lianfeng Zhang, and Chuan Qin, "The First Genetically Gene‐Edited Babies: It's “Irresponsible and Too Early”," Animal Models and Experimental Medicine ; Matthias Braun, Meacham, Darian, "The Trust Game: Crispr for Human Germline Editing Unsettles Scientists and Society," EMBO reports 20, no. 2. (shrink)

Variation, adaptation, heredity and fitness, constraints and affordances, speciation, and extinction form the building blocks of the (Neo-)Darwinian research program, and several of these have been called “Darwinian principles.” Here, we suggest that caution should be taken in calling these principles Darwinian because of the important role played by reticulate evolutionary mechanisms and processes in also bringing about these phenomena. Reticulate mechanisms and processes include symbiosis, symbiogenesis, lateral gene transfer, infective heredity mediated by genetic and organismal mobility, and hybridization. (...) Because the “Darwinian principles” are brought about by both vertical and reticulate evolutionary mechanisms and processes, they should be understood as foundational for a more pluralistic theory of evolution, one that surpasses the classic scope of the Modern and the Neo-Darwinian Synthesis. Reticulate evolution moreover demonstrates that what conventional (Neo-)Darwinian theories treat as intra-species features of evolution frequently involve reticulate interactions between organisms from very different taxonomic categories. Variation, adaptation, heredity and fitness, constraints and affordances, speciation, and extinction therefore cannot be understood as “traits” or “properties” of genes, organisms, species, or ecosystems because the phenomena are irreducible to specific units and levels of an evolutionary hierarchy. Instead, these general principles of evolution need to be understood as common goods that come about through interactions between different units and levels of evolutionary hierarchies, and they are exherent rather than inherent properties of individuals. (shrink)

Starting from the observation of the binary character YES/NOT of our decisions in relation to the information received from the environment, determining both our life and specie evolution by adaptation, it is defined the info-creational field and thought as an information operator on this field, allowing to describe the individual EGO as a receiver and producer information system, based on an operational and a programmed informational subsystem. Consciousness appears thus be an integrated information system which allows the adaptation to the (...) environment and survival of specie, supported by informed matter (physical body) to maintain functionality of the whole. On this basis, there were identified two main informational circuits of the human body controlled by the consciousness: (i) the attitude as a short-time reaction circuit allowing the immediate adaptation to the environment; (ii) the informational genetic transmission as a large-time process assuring both the evolution by the transference of the new adaptation characteristics to the next generations and the survival of the specie. Observing the anti-entropic nature of the information activity mobilized to support the living structure, there were identified the anti-entropic, antigravitational and reverse temporal arrow features that the thought could access under special focusing conditions, similar to those of antimatter, explaining the paranormal capacities like premonition, psychotherapy, telekinesis and levitation, particularly the cloud dissipation, induced/supported by the mind power. (shrink)

Breeders of purebred dogs usually have several goals they want to accomplish, of which canine wellbeing is one. The purpose of this article is to investigate what we ought to do given this goal. Breeders typically think that they fulfil their wellbeing-related duties by doing the best they can within their breed of choice. However, it is true of most breeders that they could produce physically and mentally healthier dogs if they switched to a healthier breed. There are a few (...) breeds that are healthier than other breeds as well as mutts; we could maximize wellbeing for the next generations by focusing all our breeding resources on those. However, in the long run such a strategy would severely deplete the canine gene pool. If we are to breed for wellbeing in the long run, we must thus weigh the benefits of selection against physical and mental problems against the benefits of genetic diversity. The optimal breeding strategy for canine wellbeing is to preserve many breeds, though not all of them. Furthermore, we ought to combine strict health programs with looser barriers between breeds. Such a policy conflicts with the goal of breed preservation, at least if we think of breeds as populations registered within kennel clubs rather than types of dogs, but not with the goal of producing good working dogs capable of performing various tasks. (shrink)

In both paradigm-shaping novels, the central issue is the human person: Is s/he an autonomous being, that is a “being-for-itself” (with apologies to Jean-Paul Sartre) endowed with free-will and the inherent power to organize and hence determine her/his future? Or, is s/he solely a physico-mechanical “object” whose ideas, thoughts, feelings and decisions are just by-products of her/his physico-chemical constitution, genetic configuration and environmental conditioning? From where does s/he draw the meaningfulness of her/his life? Or perhaps the more fundamental question (...) is: Is her/his life meaningful at all? Is humanity’s future predetermined by material limitations in a closed system of reality or it depends on one’s choices and decisions in a reality that is open to the unhindered operation of her/his free will? Or, given that there is human free will, could the problem lie in the condition that the majority of human beings conduct their lives like sheep in a flock whose course is stirred, regulated and determined by the strong, the tough and the powerful minority among them? Are manipulation and control an inherent dynamic to make society orderly and organized, well-coordinated, well-managed and properly governed? (shrink)

I argue that Malthus’s Essay on Population is more a treatise in applied ethics than the first treatise in demography. I argue also that, as an ethical work, it is a highly innovative one. The substitution of procreation for sex as the focus makes for a drastic change in the agenda. what had been basically lacking in the discussion up to Malthus’s time was a consideration of human beings’ own responsibility in the decision of procreating. This makes for a remarkable (...) change also in the approach, namely, the discussion becomes an examination of a well-identified issue, taking cause-effect relationships into account in order to assess possible lines of conduct in the light of some, widely shared and comparatively minimal, value judgements. This is more or less the approach of what is now called applied ethics, at least according to one of its accounts, or perhaps to the account shared by a vast majority of its practitioners. In a sense, both the subject matter, sexuality, was substituted with a more restricted issue, namely reproduction, and the traditional approach, moral doctrine, was substituted with a more modest approach, in Malthus’s own words, the “moral and political science”. Such a drastic transformation brought about a viable framework, for a discussion of ethical issues that were still unforeseen by Malthus, namely those having to do first with the technical feasibility of eugenics programs and secondly with the scientific discovery of genetics as a field of study but also of possible intervention. Malthus’s ethics had obviously enough nothing to say on those unforeseen issues in so far as it was meant to treat just the ‘quantitative’ dimension of procreation, that is, ‘how many’. Later discussions and controversies will arise around different dimensions, that is, not just ‘how many’ but also ‘how healthy, how strong, hoe empowered’, but what Malthus’s lesson could have taught and still can teach to partners defending opposite views in these controversies is that such issues may be framed in a way that possibly avoids unending controversy on incompatible ultimate principles once the strategy is turned upside down and a principle of responsibility becomes the overriding rule in the treatment of such ethical issues. -/- . (shrink)

I argue that Malthus’s Essay on Population is more a treatise in applied ethics than the first treatise in demography. I argue also that, as an ethical work, it is a highly innovative one. The substitution of procreation for sex as the focus makes for a drastic change in the agenda. What had been basically lacking in the discussion up to Malthus’s time was a consideration of human beings’ own responsibility in the decision of procreating. This makes for a remarkable (...) change also in the approach, namely, the discussion becomes an examination of a well-identified issue, taking cause-effect relationships into account in order to assess possible lines of conduct in the light of some, widely shared and comparatively minimal, value judgements. This is more or less the approach of what is now called applied ethics, at least according to one of its accounts, or perhaps to the account shared by a vast majority of its practitioners. In a sense, both the subject matter, sexuality, was substituted with a more restricted issue, namely reproduction, and the traditional approach, moral doctrine, was substituted with a more modest approach, in Malthus’s own words, the ‘moral and political science’. Such a drastic transformation brought about a viable framework, for a discussion of ethical issues that were still unforeseen by Malthus, namely those having to do first with the technical feasibility of eugenics programs and secondly with the scientific discovery of genetics as a field of study but also of possible intervention. Malthus’s ethics had obviously enough nothing to say on those unforeseen issues in so far as it was meant to treat just the ‘quantitative’ dimension of procreation, that is, ‘how many’. Later discussions and controversies will arise around different dimensions, that is, not just ‘how many’ but also ‘how healthy, how strong, how far empowered’. Yet, what Malthus’s lesson can still teach to proponents of opposite views is that the mentioned questions can be construed in such a way as to avoid unending controversy. (shrink)

This paper focuses on Precision Public Health (PPH), described in the scientific literature as an effort to broaden the scope of precision medicine by extrap- olating it towards public health. By means of the “All of Us” (AoU) research pro- gram, launched by the National Institutes of Health in the U.S., PPH is being devel- oped based on health data shared through a broad range of digital tools. PPH is an emerging idea to harness the data collected for precision medicine (...) to be able to tai- lor preventive interventions for at-risk groups. The character of these data concern genetic identity, lifestyle and overall health and therefore affect the ‘intimacy’ of personhood. Through the concept of biological citizenship, we elucidate how AoU and its recruitment tactics, by resonating ‘diversity’, at the same time appeal to and constitute identity, defining individuals as ‘data sharing subjects’. Although PPH is called for; the type of bio-citizenship that is enacted here, has a particular definition, where participant recruitment focuses on ‘citizenship’ in terms of empowerment (front), it is the ‘bio’ prefix that has become the main focus in terms of research. i.e. biosubjectivities vs biocapital. This raises the question whether the societal chal- lenges that often underlie public health issues can be sufficiently dealt with based on the way ‘diversity’ is accounted for in the program. We suggest that the AoU still risks of harming underrepresented groups based on the preconditions and the design of the program. (shrink)

The book is an in-depth study of naturalized epistemology in its two versions - physicalist and evolutionist. At the same time, it is the sole existing detailed discussion of evolutionary epistemology (as far as Polish and foreign literature is concerned). Malinowska asks about the ontological, methodological, and epistemological foundations of the positions she discusses. She argues (referring not only to philosophical discussions but also those in the field of neuroscience or genetics) that bio-cultural constructivism (a research program pursued by cultural (...) neuroscience, among other fields) is a contemporary, interdisciplinary continuation of the evolutionary epistemology program. The book’s accessible language, clear structure and multidisciplinary nature make it an exciting read for a wide audience. (shrink)

UNESCO Universal Declaration on Cultural Diversity (2 November 2001) defines culture with an emphasis on cultural features: “culture should be regarded as the set of distinctive spiritual, material, intellectual and emotional features of society or a social group”, encompassing, “in addition to art and literature, lifestyles, ways of living together, value systems, traditions and beliefs”. Cultural traits are also the primitive of mathematical models of cultural transmission inspired by population genetics, imported and refined by economics. Any serious evaluation of the (...) notion of “cultural trait”, however, requires the interrogation of many disciplines, from cultural anthropology to linguistics, from psychology to archaeology to musicology. The very possibility of assuming the existence of cultural traits is not granted. In order to start a wide interdisciplinary confrontation, we need a sufficiently loose definition of a cultural trait as any trait whose production in individuals depends, to some extent, on social learning; and we need a deflationary interpretive horizon where cultural traits are not expected to provide an exhaustive theory of culture and cultural change. But from there, we can go a long way if each of the involved disciplines enters the debate with a self-presenting attitude, emphasizing its own methodological practices, and explaining whether and how cultural traits have a role in its own research programs and epistemic goals. Are there differences in aspects of culture that are studied by different disciplines? What definitions of cultural traits are on the table? How do we delimit a trait? How is the problem declined at different observational scales, and which scales are most in focus? Do traits travel in geographical space, and how? Are there other relevant spaces? How are traits modified in their diffusion? Is it possible and useful to build models of this diffusion? Only a strong multidisciplinary perspective can help to clarify these problems about cultural traits, by means of which we understand our precious heritage, cultural diversity. (shrink)

It is well known that modern epistemology is a discipline that was left as a legacy by the great French philosopher René Descartes, and it is generally believed that it is a typically philosophical discipline whose problems can be dealt with only by philosophical (speculative) means of inquiry. Recently, however, the idea of naturalization of epistemological inquiry has emerged, and one of its most prominent advocates was Quine. However, the question is to what extent, if at all, the proposal offered (...) by Quine is tenable, as evidenced, apart from numerous criticisms, by significantly different interpretations regarding assumptions on which it should be based. Namely, three types of interpretations of Quine’s call for the reform of epistemological inquiry prevail in contemporary literature: behaviorist, which was largely advocated by Quine, but also coherentist and physicalist, which some of his interpreters argued for. However, while the first two of these options are in my opinion unacceptable because they are unable to provide the necessary autonomy for the epistemological context of inquiry, I will try to show that physicalism is also burdened with difficulties, albeit different ones, which make it an untenable position when it comes to epistemological inquiry. Nevertheless, even before I started writing, I thought that there were valuable insights in Quine’s proposal, and that we could learn important lessons from the failure of previous interpretations, both regarding the position that should be taken in its interpretation, and, closely related to this, the possibility of reforming epistemological inquiry in general. In other words, informed by the weaknesses of Quine’s proposal and its interpretations, I will argue that epistemological inquiry can ultimately be approached from one of two mutually incompatible theoretical positions: the traditional or Cartesian one, and the Kantian one. Given that, as noted above, Quine’s proposal was primarily a reaction to Cartesianism, I discuss the possibility of establishing the fundamental level of inquiry such as epistemological to which Quine had to aspire, but in a way that would enable the synthesis of his approach with Kant’s view, which is in my opinion the only genuine alternative to the traditional program. Although it implies taking a position that would be a kind of compromise and could not be attributed to Quine (which is why it is uncertain whether he would have supported this interpretation), I believe that, apart from preserving certain naturalistic elements, it is an interpretation that would ultimately satisfy most of the demands that Quine himself has set for epistemological inquiry. (shrink)

The mantra that "the best way to predict the future is to invent it" (attributed to the computer scientist Alan Kay) exemplifies some of the expectations from the technical and innovative sides of biomedical research at present. However, for technical advancements to make real impacts both on patient health and genuine scientific understanding, quite a number of lingering challenges facing the entire spectrum from protein biology all the way to randomized controlled trials should start to be overcome. The proposal in (...) this chapter is that philosophy is essential in this process. By reviewing select examples from the history of science and philosophy, disciplines which were indistinguishable until the mid-nineteenth century, I argue that progress toward the many impasses in biomedicine can be achieved by emphasizing theoretical work (in the true sense of the word 'theory') as a vital foundation for experimental biology. Furthermore, a philosophical biology program that could provide a framework for theoretical investigations is outlined. (shrink)

In this paper I argue that the extent to which a human trait is genetically caused can causally depend upon whether the trait is categorized within human genetics as genetically caused. This makes the kind genetically caused trait an interactive kind. I demonstrate that this thesis is both conceptually coherent and empirically plausible. I outline the core rationale of this thesis and demonstrate its conceptual coherence by drawing upon Waters’ (2007) analysis of genetic causation. I add empirical plausibility to (...) the thesis by describing a hypothetical but empirically plausible mechanism by which the fact that obesity is categorized as genetically caused within human genetics increases the extent to which obesity is in fact genetically caused. (shrink)

Genetic engineering technologies are a subclass of the biotechnology family, and are concerned with the use of laboratory-based technologies to intervene with a given organism at the genetic level, i.e., the level of its DNA. This class of technologies could feasibly be used to treat diseases and disabilities, create disease-resistant crops, or even be used to enhance humans to make them more resistant to certain environmental conditions. However, both therapeutic and enhancement applications of genetic engineering raise serious (...) ethical concerns. This paper examines various objections to genetic engineering (as applied to humans) which have been raised in the literature, and presents a new way to frame these issues, and to look for solutions. Specifically, this paper frames genetic engineering technologies within the ‘design turn in applied ethics’ lens and thus situates these technologies as covarying with societal forces. The value sensitive design (VSD) approach to technology design is then appropriated as the conceptual framework in which genetic engineering technologies can be considered so that they can be designed for important human values. By doing so, this paper brings further nuance to the scholarship on genetic engineering technologies by discussing the sociotechnicity of genetic engineering systems rather than framing them as value-neutral tools that either support or constrain values based on how they are used. (shrink)

Genetically engineered (GE) insects, such as the GE OX513A Aedes aegypti mosquitoes, have been designed to suppress their wild-type populations so as to reduce the transmission of vector-borne diseases in humans. Apart from the ecological and epidemiological uncertainties associated with this approach, such biotechnological approaches may be used by individual governments or the global community of nations to avoid addressing the underlying structural, systemic causes of those infections... We discuss here key ethical questions raised by the use of GE mosquitoes, (...) with the aim of fostering discussion between the public, researchers, policy makers, healthcare organizations, and regulatory agencies at the local, national, and international levels. We affect that goal by outlining a procedural approach to decision-making about the use of the “biotechnology” that goes beyond “community engagement.” The protocol we advocate for entails informed deliberations and decision-making at the community level. It is designed to ensure that the voices of the marginalized and vulnerable groups that would be disproportionately affected by the decision are heard during the community-wide discussions. Moreover, we make the case that the values embedded in the risk assessment should be identified so that the community can make an informed decision about the use of GE insects. In addition, we advocate for the involvement of a variety of actors whose responsibility would be to ensure that the community has the opportunity to make an informed decision based on deliberations about the use of the “biotechnology.”. (shrink)

The cumulative impact of enhancement technologies may alter the human species in the very long-term future. In this article, I will start showing how radical genetic enhancements may accelerate the conversion into a novel species. I will also clarify the concepts of ‘biological species’, ‘transhuman’ and ‘posthuman’. Then, I will summarize some ethical arguments for creating a transhuman or posthuman species with a substantially higher level of well-being than the human one. In particular, I will present what I shall (...) call the Principle of the Best Interests of Posthumanity, which states that the enhancement of the human and transhuman species must be directed towards the creation of a posthuman existence that is substantially more valuable than its predecessors. I suggest that human extinction may be considered, within that principle, as one of the best interests of posthumanity. Finally, I will develop three objections that make that principle unattractive and that show that pursuing a full-blown programme of posthuman evolution is ethically flawed. (shrink)

This article illustrates in which sense genetic determinism is still part of the contemporary interactionist consensus in medicine. Three dimensions of this consensus are discussed: kinds of causes, a continuum of traits ranging from monogenetic diseases to car accidents, and different kinds of determination due to different norms of reaction. On this basis, this article explicates in which sense the interactionist consensus presupposes the innate?acquired distinction. After a descriptive Part 1, Part 2 reviews why the innate?acquired distinction is under (...) attack in contemporary philosophy of biology. Three arguments are then presented to provide a limited and pragmatic defense of the distinction: an epistemic, a conceptual, and a historical argument. If interpreted in a certain manner, and if the pragmatic goals of prevention and treatment are taken into account, then the innate?acquired distinction can be a useful epistemic tool. It can help, first, to understand that genetic determination does not mean fatalism, and, second, to maintain a system of checks and balances in the continuing nature?nurture debates. (shrink)