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Re-engineering philosophy for limited beings: piecewise approximations to reality

Cambridge, Mass.: Harvard University Press (2007)

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  1. Pharmacological Interventions and the Neurobiological Basis of Mental Disorders.Jonathan Y. Tsou - 2017 - In Ioan Opris & Manuel F. Casanova (eds.), The Physics of the Mind and Brain Disorders: Integrated Neural Circuits Supporting the Emergence of Mind. Cham: Springer. pp. 613-628.
    In psychiatry, pharmacological research has played a crucial role in the formulation, revision, and refinement of neurobiological theories of psychopathology. Besides being utilized as potential treatments for various mental disorders, pharmacological drugs play an important epistemic role as experimental instruments that help scientists uncover the neurobiological underpinnings of mental disorders (Tsou, 2012). Interventions with psychiatric patients using pharmacological drugs provide researchers with information about the neurobiological causes of mental disorders that cannot be obtained in other ways. This important source of (...)
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  • Natural Kinds, Psychiatric Classification and the History of the DSM.Jonathan Y. Tsou - 2016 - History of Psychiatry 27 (4):406-424.
    This paper addresses philosophical issues concerning whether mental disorders are natural kinds and how the DSM should classify mental disorders. I argue that some mental disorders (e.g., schizophrenia, depression) are natural kinds in the sense that they are natural classes constituted by a set of stable biological mechanisms. I subsequently argue that a theoretical and causal approach to classification would provide a superior method for classifying natural kinds than the purely descriptive approach adopted by the DSM since DSM-III. My argument (...)
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  • An Inferential Account of Model Explanation.Wei Fang - 2019 - Philosophia 47 (1):99-116.
    This essay develops an inferential account of model explanation, based on Mauricio Suárez’s inferential conception of scientific representation and Alisa Bokulich’s counterfactual account of model explanation. It is suggested that the fact that a scientific model can explain is essentially linked to how a modeler uses an established model to make various inferences about the target system on the basis of results derived from the model. The inference practice is understood as a two-step activity, with the first step involving making (...)
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  • Philosophy of Science for Sustainability Science.Michiru Nagatsu, Taylor Thiel Davis, C. Tyler DesRoches, Inkeri Koskinen, Miles MacLeod, Milutin Stojanovic & Henrik Thorén - 2020 - Sustainability Science 1 (N/A):1-11.
    Sustainability science seeks to extend scientific investigation into domains characterized by a distinct problem-solving agenda, physical and social complexity, and complex moral and ethical landscapes. In this endeavor it arguably pushes scientific investigation beyond its usual comfort zones, raising fundamental issues about how best to structure such investigation. Philosophers of science have long scrutinized the structure of science and scientific practices, and the conditions under which they operate effectively. We propose a critical engagement between sustainability scientists and philosophers of science (...)
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  • Emerging into the Rainforest: Emergence and Special Science Ontology.Alexander Franklin & Katie Robertson - manuscript
    Many philosophers of science are ontologically committed to a lush rainforest of special science entities ), but are often reticent about the criteria that determine which entities count as real. On the other hand, the metaphysics literature is much more forthcoming about such criteria, but often links ontological commitment to irreducibility. We argue that the irreducibility criteria are in tension with scientific realism: for example, they would exclude viruses, which are plausibly theoretically reducible and yet play a sufficiently important role (...)
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  • Levels, Individual Variation and Massive Multiple Realization in Neurobiology.Kenneth Aizawa & Carl Gillett - 2009 - In John Bickle (ed.), The Oxford handbook of philosophy and neuroscience. New York: Oxford University Press. pp. 539--582.
    Biologists seems to hold two fundamental beliefs: Organisms are organized into levels and the individuals at these levels differ in their properties. Together these suggest that there will be massive multiple realization, i.e. that many human psychological properties are multiply realized at many neurobiological levels. This paper provides some documentation in support of this suggestion.
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  • Whewell’s hylomorphism as a metaphorical explanation for how mind and world merge.Ragnar van der Merwe - 2023 - Journal for General Philosophy of Science / Zeitschrift für Allgemeine Wissenschaftstheorie 54 (1):19-38.
    William Whewell’s 19th century philosophy of science is sometimes glossed over as a footnote to Kant. There is however a key feature of Whewell’s account worth noting. This is his appeal to Aristotle’s form/matter hylomorphism as a metaphor to explain how mind and world merge in successful scientific inquiry. Whewell’s hylomorphism suggests a middle way between rationalism and empiricism reminiscent of experience pragmatists like Steven Levine’s view that mind and world are entwined in experience. I argue however that Levine does (...)
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  • Philosophy of Psychiatry.Jonathan Y. Tsou - 2021 - Cambridge: Cambridge University Press.
    Jonathan Y. Tsou examines and defends positions on central issues in philosophy of psychiatry. The positions defended assume a naturalistic and realist perspective and are framed against skeptical perspectives on biological psychiatry. Issues addressed include the reality of mental disorders; mechanistic and disease explanations of abnormal behavior; definitions of mental disorder; natural and artificial kinds in psychiatry; biological essentialism and the projectability of psychiatric categories; looping effects and the stability of mental disorders; psychiatric classification; and the validity of the DSM's (...)
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  • Psychoneural Isomorphism: From Metaphysics to Robustness.Alfredo Vernazzani - 2020 - In Marco Viola & Fabrizio Calzavarini (eds.), Neural Mechanisms: New Challenges in the Philosophy of Neuroscience. Springer.
    At the beginning of the 20th century, Gestalt psychologists put forward the concept of psychoneural isomorphism, which was meant to replace Fechner’s obscure notion of psychophysical parallelism and provide a heuristics that may facilitate the search for the neural correlates of the mind. However, the concept has generated much confusion in the debate, and today its role is still unclear. In this contribution, I will attempt a little conceptual spadework in clarifying the concept of psychoneural isomorphism, focusing exclusively on conscious (...)
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  • Prediction in selectionist evolutionary theory.Rasmus Gr⊘Nfeldt Winther - 2009 - Philosophy of Science 76 (5):889-901.
    Selectionist evolutionary theory has often been faulted for not making novel predictions that are surprising, risky, and correct. I argue that it in fact exhibits the theoretical virtue of predictive capacity in addition to two other virtues: explanatory unification and model fitting. Two case studies show the predictive capacity of selectionist evolutionary theory: parallel evolutionary change in E. coli, and the origin of eukaryotic cells through endosymbiosis.
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  • Coherent Causal Control: A New Distinction within Causation.Marcel Weber - 2022 - European Journal for Philosophy of Science 12 (4):69.
    The recent literature on causality has seen the introduction of several distinctions within causality, which are thought to be important for understanding the widespread scientific practice of focusing causal explanations on a subset of the factors that are causally relevant for a phenomenon. Concepts used to draw such distinctions include, among others, stability, specificity, proportionality, or actual-difference making. In this contribution, I propose a new distinction that picks out an explanatorily salient class of causes in biological systems. Some select causes (...)
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  • Biological Parts.Marie I. Kaiser - 2017 - In H. Burkhardt, J. Seibt & G. Imaguire (eds.), Handbook of Mereology. München: Philosophia Verlag GmbH. pp. 97-100.
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  • Reduction.A. Hütterman & A. C. Love - 2016 - In Paul Humphreys (ed.), The Oxford Handbook of Philosophy of Science. Oxford University Press USA. pp. 460-484.
    Reduction and reductionism have been central philosophical topics in analytic philosophy of science for more than six decades. Together they encompass a diversity of issues from metaphysics and epistemology. This article provides an introduction to the topic that illuminates how contemporary epistemological discussions took their shape historically and limns the contours of concrete cases of reduction in specific natural sciences. The unity of science and the impulse to accomplish compositional reduction in accord with a layer-cake vision of the sciences, the (...)
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  • Evo-Devo as a Trading Zone.Rasmus Grønfeldt Winther - 2015 - In Alan C. Love (ed.), Conceptual Change in Biology: Scientific and Philosophical Perspectives on Evolution and Development. Berlin: Springer Verlag, Boston Studies in the Philosophy of Science.
    Evo-Devo exhibits a plurality of scientific “cultures” of practice and theory. When are the cultures acting—individually or collectively—in ways that actually move research forward, empirically, theoretically, and ethically? When do they become imperialistic, in the sense of excluding and subordinating other cultures? This chapter identifies six cultures – three /styles/ (mathematical modeling, mechanism, and history) and three /paradigms/ (adaptationism, structuralism, and cladism). The key assumptions standing behind, under, or within each of these cultures are explored. Characterizing the internal structure of (...)
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  • The Volterra Principle Generalized.Tim Räz - 2017 - Philosophy of Science 84 (4):737-760.
    Michael Weisberg and Kenneth Reisman argue that the Volterra Principle can be derived from multiple predator-prey models and that, therefore, the Volterra Principle is a prime example for robustness analysis. In the current article, I give new results regarding the Volterra Principle, extending Weisberg’s and Reisman’s work, and I discuss the consequences of these results for robustness analysis. I argue that we do not end up with multiple, independent models but rather with one general model. I identify the kind of (...)
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  • Sens et neurosciences. Étude critique de Paul Thagard, The Brain and the Meaning of Life, Princeton University Press, 2010, 274 pagesÉtude critique de Paul Thagard, The Brain and the Meaning of Life, Princeton University Press, 2010, 274 pages. [REVIEW]Jean-Frédéric de Pasquale - 2011 - Philosophiques 38 (2):579-595.
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  • Beyond the limit: carrying capacity (K) and the holism/reductionism debate.Julien Delord - 2021 - History and Philosophy of the Life Sciences 43 (3):1-25.
    As the debate about holism and reductionism in ecology has ebbed in the last twenty years, this article aims to reassess the traditional opposition between holistic and reductionist epistemologies during the development of population biology. The history of the notion of carrying capacity, the upper demographic limit of a viable population, will be analyzed as a paradigmatic case of the progressive imposition of reductionist strategies, from both an epistemological and a semantic point of view, since the middle of the twentieth (...)
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  • Towards a theory of emergence for the physical sciences.Sebastian De Haro - 2019 - European Journal for Philosophy of Science 9 (3):1-52.
    I begin to develop a framework for emergence in the physical sciences. Namely, I propose to explicate ontological emergence in terms of the notion of ‘novel reference’, and of an account of interpretation as a map from theory to world. I then construe ontological emergence as the “failure of the interpretation to mesh” with an appropriate linkage map between theories. Ontological emergence can obtain between theories that have the same extension but different intensions, and between theories that have both different (...)
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  • The Objectivity of Organizational Functions.Samuel Cusimano & Beckett Sterner - 2020 - Acta Biotheoretica 68 (2):253-269.
    We critique the organizational account of biological functions by showing how its basis in the closure of constraints fails to be objective. While the account treats constraints as objective features of physical systems, the number and relationship of potential constraints are subject to potentially arbitrary redescription by investigators. For example, we show that self-maintaining systems such as candle flames can realize closure on a more thorough analysis of the case, contradicting the claim that these “simple” systems lack functional organization. This (...)
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  • Big dragons on small islands: generality and particularity in science: Review of Angela Potochnik’s idealization and the aims of science.Adrian Currie - 2018 - Biology and Philosophy 33 (3-4):20.
    Angela Potochnik’s Idealization and the Aims of Science defends an ambitious and systematic account of scientific knowledge: ultimately science pursues human understanding rather than truth. Potochnik argues that idealization is rampant and unchecked in science. Further, given that idealizations involve departures from truth, this suggests science is not primarily about truth. I explore the relationship between truths about causal patterns and scientific understanding in light of this, and suggest that Potochnik underestimates the importance and power of highly particular narrative explanations.
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  • The Multiple Dimensions of Multiple Determination.Klodian Coko - 2020 - Perspectives on Science 28 (4):505-541.
    Multiple determination is the epistemic strategy of establishing the same result by means of multiple, independent procedures. It is an important strategy praised by both philosophers of science and practicing scientists. Despite the heavy appeal to multiple determination, little analysis has been provided regarding the specific grounds upon which its epistemic virtues rest. This article distinguishes between the various dimensions of multiple determination and shows how they can be used to evaluate the epistemic force of the strategy in particular cases. (...)
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  • Many Meanings of ‘Heuristic’.Sheldon J. Chow - 2015 - British Journal for the Philosophy of Science 66 (4):977-1016.
    A survey of contemporary philosophical and scientific literatures reveals that different authors employ the term ‘heuristic’ in ways that deviate from, and are sometimes inconsistent with, one another. Given its widespread use in philosophy and cognitive science generally, it is striking that there appears to be little concern for a clear account of what phenomena heuristics pick out or refer to. In response, I consider several accounts of ‘heuristic’, and I draw a number of distinctions between different sorts of heuristics (...)
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  • Toward a Social Ontology of the Firm: Reconstitution, Organizing Entity, Institution, Social Emergence and Power.Virgile Chassagnon - 2014 - Journal of Business Ethics 124 (2):197-208.
    In the past half century, the theory of the firm has become a specific and prolific research field. However, the social ontology of this central institution of capitalism has never truly been the subject of investigation. I consider this negligence harmful for organizational economics and management and, more broadly, for the social sciences, notably because the first and central question raised by the theory of the firm relates to its nature: What is a firm? For this reason, I propose some (...)
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  • False beliefs and naive beliefs: They can be good for you.Roberto Casati & Marco Bertamini - 2009 - Behavioral and Brain Sciences 32 (6):512-513.
    Naive physics beliefs can be systematically mistaken. They provide a useful test-bed because they are common, and also because their existence must rely on some adaptive advantage, within a given context. In the second part of the commentary we also ask questions about when a whole family of misbeliefs should be considered together as a single phenomenon.
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  • Can Interventions Rescue Glennan’s Mechanistic Account of Causality?Lorenzo Casini - 2016 - British Journal for the Philosophy of Science 67 (4):1155-1183.
    Glennan appeals to interventions to solve the ontological and explanatory regresses that threaten his mechanistic account of causality . I argue that Glennan’s manoeuvre fails. The appeal to interventions is not able to address the ontological regress, and it blocks the explanatory regress only at the cost of making the account inapplicable to non-modular mechanisms. I offer a solution to the explanatory regress that makes use of dynamic Bayesian networks. My argument is illustrated by a case study from systems biology, (...)
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  • Explanatory organization and psychiatric resilience: Challenges to a mechanistic approach to mental disorders.Raffaella Campaner - 2020 - Rivista Internazionale di Filosofia e Psicologia 11 (1):128-144.
    : This contribution aims to address epistemological issues at the crossroads of philosophy of science and psychiatry by reflecting on the notions of organization and resilience. Referring to the debate on the notion of “organization” and its explanatory relevance in philosophical neo-mechanistic theories, I consider how such positions hold up when tentatively applied to the mental health context. More specifically, I show how reflections on psychiatric resilience, cognitive reserve, and accommodation strategies challenge attempts to embrace a mechanistic perspective on mental (...)
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  • Wimsatt and the robustness family: Review of Wimsatt’s Re-engineering Philosophy for Limited Beings. [REVIEW]Brett Calcott - 2011 - Biology and Philosophy 26 (2):281-293.
    This review of Wimsatt’s book Re-engineering Philosophy for Limited Beings focuses on analysing his use of robustness, a central theme in the book. I outline a family of three distinct conceptions of robustness that appear in the book, and look at the different roles they play. I briefly examine what underwrites robustness, and suggest that further work is needed to clarify both the structure of robustness and the relation between it various conceptions.
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  • Naturalizing Theorizing: Beyond a Theory of Biological Theories. [REVIEW]Werner Callebaut - 2013 - Biological Theory 7 (4):413-429.
    Although “theory” has been the prevalent unit of analysis in the meta-study of science throughout most of the twentieth century, the concept remains elusive. I further explore the leitmotiv of several authors in this issue: that we should deal with theorizing (rather than theory) in biology as a cognitive activity that is to be investigated naturalistically. I first contrast how philosophers and biologists have tended to think about theory in the last century or so, and consider recent calls to upgrade (...)
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  • Engineering and Biology: Counsel for a Continued Relationship.Brett Calcott, Arnon Levy, Mark L. Siegal, Orkun S. Soyer & Andreas Wagner - 2015 - Biological Theory 10 (1):50-59.
    Biologists frequently draw on ideas and terminology from engineering. Evolutionary systems biology—with its circuits, switches, and signal processing—is no exception. In parallel with the frequent links drawn between biology and engineering, there is ongoing criticism against this cross-fertilization, using the argument that over-simplistic metaphors from engineering are likely to mislead us as engineering is fundamentally different from biology. In this article, we clarify and reconfigure the link between biology and engineering, presenting it in a more favorable light. We do so (...)
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  • The Things in Heaven and Earth: An Essay in Pragmatic Naturalism. By John Ryder. New York: Fordham University Press, 2013. Pp. xiii + 327. [REVIEW]Lawrence Cahoone - 2013 - Metaphilosophy 44 (5):708-713.
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  • The emergence of value: human norms in a natural world.Lawrence Cahoone - 2023 - Albany: State University of New York Press.
    Argues that truth, moral right, political right, and aesthetic value may be understood as arising out of a naturalist account of humanity, if naturalism is rightly conceived.
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  • Self-, Social-, or Neural-Determination?Lawrence Cahoone - 2019 - Journal of Philosophical Investigations 13 (28):95-108.
    Human “free will” has been made problematic by several recent arguments against mental causation, the unity of the I or “self,” and the possibility that conscious decision-making could be temporally prior to action. This paper suggests a pathway through this thicket for free will or self-determination. Doing so requires an account of mind as an emergent process in the context of animal psychology and mental causation. Consciousness, a palpable but theoretically more obscure property of some minds, is likely to derive (...)
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  • Local Naturalism.Lawrence Cahoone - 2009 - Contemporary Pragmatism 6 (2):1-23.
    Robert Brandom's book Between Saying and Doing: Towards an Analytic Pragmatism does not incorporate the larger views of any of the “pragmatisms” he deliberately invokes, such as those of the classical American pragmatists, apart from an “analytic” cohort of Wittgenstein-inspired pragmatisms that he himself favors.
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  • Smaller than a Breadbox: Scale and Natural Kinds.Julia R. Bursten - 2018 - British Journal for Philosophy of Science 69 (1):1-23.
    ABSTRACT I propose a division of the literature on natural kinds into metaphysical worries, semantic worries, and methodological worries. I argue that the latter set of worries, which concern how classification influences scientific practices, should occupy centre stage in philosophy of science discussions about natural kinds. I apply this methodological framework to the problems of classifying chemical species and nanomaterials. I show that classification in nanoscience differs from classification in chemistry because the latter relies heavily on compositional identity, whereas the (...)
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  • The Measurement Problem of Consciousness.Heather Browning & Walter Veit - 2020 - Philosophical Topics 48 (1):85-108.
    This paper addresses what we consider to be the most pressing challenge for the emerging science of consciousness: the measurement problem of consciousness. That is, by what methods can we determine the presence of and properties of consciousness? Most methods are currently developed through evaluation of the presence of consciousness in humans and here we argue that there are particular problems in application of these methods to nonhuman cases—what we call the indicator validity problem and the extrapolation problem. The first (...)
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  • Learning, evolvability and exploratory behaviour: extending the evolutionary reach of learning.Rachael L. Brown - 2013 - Biology and Philosophy 28 (6):933-955.
    Traditional accounts of the role of learning in evolution have concentrated upon its capacity as a source of fitness to individuals. In this paper I use a case study from invasive species biology—the role of conditioned taste aversion in mitigating the impact of cane toads on the native species of Northern Australia—to highlight a role for learning beyond this—as a source of evolvability to populations. This has two benefits. First, it highlights an otherwise under-appreciated role for learning in evolution that (...)
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  • Is absence of evidence of pain ever evidence of absence?Deborah J. Brown & Brian Key - 2021 - Synthese 199 (1-2):3881-3902.
    Absence of evidence arguments are indispensable to comparative neurobiology. The absence in a given species of a homologous neural architecture strongly correlated with a type of conscious experience in humans should be able to be taken as a prima facie reason for concluding that the species in question does not have the capacity for that conscious experience. Absence of evidence reasoning is, however, widely disparaged for being both logically illicit and unscientific. This paper argues that these concerns are unwarranted. There (...)
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  • A New Look at ‘Levels of Organization’ in Biology.Daniel S. Brooks - 2021 - Erkenntnis 86.
    Despite its pervasiveness, the concept of ‘levels of organization’ has received relatively little attention in its own right. I propose here an emerging approach that posits ‘levels’ as a fragmentary concept situated within an interest-relative matrix of operational usage within scientific practice. To this end I propose one important component of meaning, namely the epistemic goal motivating the term’s usage, which recovers a remarkably conserved and sufficiently unifying significance attributable to ‘levels’ across different instances of usage. This epistemic goal, to (...)
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  • Systems biology and the integration of mechanistic explanation and mathematical explanation.Ingo Brigandt - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):477-492.
    The paper discusses how systems biology is working toward complex accounts that integrate explanation in terms of mechanisms and explanation by mathematical models—which some philosophers have viewed as rival models of explanation. Systems biology is an integrative approach, and it strongly relies on mathematical modeling. Philosophical accounts of mechanisms capture integrative in the sense of multilevel and multifield explanations, yet accounts of mechanistic explanation have failed to address how a mathematical model could contribute to such explanations. I discuss how mathematical (...)
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  • Explanation in Biology: Reduction, Pluralism, and Explanatory Aims.Ingo Brigandt - 2011 - Science & Education 22 (1):69-91.
    This essay analyzes and develops recent views about explanation in biology. Philosophers of biology have parted with the received deductive-nomological model of scientific explanation primarily by attempting to capture actual biological theorizing and practice. This includes an endorsement of different kinds of explanation (e.g., mathematical and causal-mechanistic), a joint study of discovery and explanation, and an abandonment of models of theory reduction in favor of accounts of explanatory reduction. Of particular current interest are philosophical accounts of complex explanations that appeal (...)
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  • Transitions in evolution: a formal analysis.Pierrick Bourrat - 2021 - Synthese 198 (4):3699-3731.
    Evolutionary transitions in individuality (ETIs) are events during which individuals at a given level of organization (particles) interact to form higher-level entities (collectives) which are then recognized as new individuals at that level. ETIs are intimately related to levels of selection, which, following Okasha, can be approached from two different perspectives. One, referred to as ‘synchronic’, asks whether selection occurs at the collective level while the partitioning of particles into collectives is taken for granted. The other, referred to as ‘diachronic’, (...)
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  • Mechanistic Explanations and Models in Molecular Systems Biology.Fred C. Boogerd, Frank J. Bruggeman & Robert C. Richardson - 2013 - Foundations of Science 18 (4):725-744.
    Mechanistic models in molecular systems biology are generally mathematical models of the action of networks of biochemical reactions, involving metabolism, signal transduction, and/or gene expression. They can be either simulated numerically or analyzed analytically. Systems biology integrates quantitative molecular data acquisition with mathematical models to design new experiments, discriminate between alternative mechanisms and explain the molecular basis of cellular properties. At the heart of this approach are mechanistic models of molecular networks. We focus on the articulation and development of mechanistic (...)
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  • Complexity and integration. A philosophical analysis of how cancer complexity can be faced in the era of precision medicine.Giovanni Boniolo & Raffaella Campaner - 2019 - European Journal for Philosophy of Science 9 (3):1-25.
    Complexity and integration are longstanding widely debated issues in philosophy of science and recent contributions have largely focused on biology and biomedicine. This paper specifically considers some methodological novelties in cancer research, motivated by various features of tumours as complex diseases, and shows how they encourage some rethinking of philosophical discourses on those topics. In particular, we discuss the integrative-cluster approach, and analyse its potential in the epistemology of cancer. We suggest that, far from being the solution to tame cancer (...)
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  • The Use of Natural Kinds in Evolutionary Developmental Biology.Jessica Bolker - 2013 - Biological Theory 7 (2):121-129.
    Evolutionary developmental biologists categorize many different kinds of things, from ontogenetic stages to modules of gene activity. The process of categorization—the establishment of “kinds”—is an implicit part of describing the natural world in consistent, useful ways, and has an essentially practical rather than philosophical basis. Kinds commonly serve one of three purposes: they may function (1) as practical tools for communication; (2) to support prediction and generalization; or (3) as a basis for theoretical discussions. Beyond the minimal requirement that classifications (...)
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  • Data models, representation and adequacy-for-purpose.Alisa Bokulich & Wendy Parker - 2021 - European Journal for Philosophy of Science 11 (1):1-26.
    We critically engage two traditional views of scientific data and outline a novel philosophical view that we call the pragmatic-representational view of data. On the PR view, data are representations that are the product of a process of inquiry, and they should be evaluated in terms of their adequacy or fitness for particular purposes. Some important implications of the PR view for data assessment, related to misrepresentation, context-sensitivity, and complementary use, are highlighted. The PR view provides insight into the common (...)
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  • What’s so special about empirical adequacy?Sindhuja Bhakthavatsalam & Nancy Cartwright - 2017 - European Journal for Philosophy of Science 7 (3):445-465.
    Empirical adequacy matters directly - as it does for antirealists - if we aim to get all or most of the observable facts right, or indirectly - as it does for realists - as a symptom that the claims we make about the theoretical facts are right. But why should getting the facts - either theoretical or empirical - right be required of an acceptable theory? Here we endorse two other jobs that good theories are expected to do: helping us (...)
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  • From parts to mechanisms: research heuristics for addressing heterogeneity in cancer genetics.William Bechtel - 2019 - History and Philosophy of the Life Sciences 41 (3):27.
    A major approach to cancer research in the late twentieth century was to search for genes that, when altered, initiated the development of a cell into a cancerous state or failed to stop this development. But as researchers acquired the capacity to sequence tumors and incorporated the resulting data into databases, it became apparent that for many tumors no genes were frequently altered and that the genes altered in different tumors in the same tissue type were often distinct. To address (...)
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  • Mapping the continuum of research strategies.Matthew Baxendale - 2019 - Synthese 196 (11):4711-4733.
    Contemporary philosophy of science has seen a growing trend towards a focus on scientific practice over the epistemic outputs that such practices produce. This practice-oriented approach has yielded a clearer understanding of how reductive research strategies play a central role in contemporary scientific inquiry. In parallel, a growing body of work has sought to explore the role of non-reductive, or systems-level, research strategies. As a result, the relationship between reductive and non-reductive scientific practices is becoming of increased importance. In this (...)
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  • Rendering Interventionism and Non‐Reductive Physicalism Compatible.Michael Baumgartner - 2013 - Dialectica 67 (1):1-27.
    In recent years, the debate on the problem of causal exclusion has seen an ‘interventionist turn’. Numerous non-reductive physicalists (e.g. Shapiro and Sober 2007) have argued that Woodward's (2003) interventionist theory of causation provides a means to empirically establish the existence of non-reducible mental-to-physical causation. By contrast, Baumgartner (2010) has presented an interventionist exclusion argument showing that interventionism is in fact incompatible with non-reductive physicalism. In response, a number of revised versions of interventionism have been suggested that are compatible with (...)
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  • The manipulability of what? The history of G-protein coupled receptors.Ann-Sophie Barwich & Karim Bschir - 2017 - Biology and Philosophy 32 (6):1317-1339.
    This paper tells the story of G-protein coupled receptors, one of the most important scientific objects in contemporary biochemistry and molecular biology. By looking at how cell membrane receptors turned from a speculative concept into a central element in modern biochemistry over the past 40 years, we revisit the role of manipulability as a criterion for entity realism in wet-lab research. The central argument is that manipulability as a condition for reality becomes meaningful only once scientists have decided how to (...)
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