ABSTRACTEvaluative aesthetic discourse communicates that the speaker has had first-hand experience of what is talked about. If you call a book bewitching, it will be assumed that you have read the book. If you say that a building is beautiful, it will be assumed that you have had some visual experience with it. According to an influential view, this is because knowledge is a norm for assertion, and aesthetic knowledge requires first-hand experience. This paper criticizes this view and argues for (...) an alternative view, according to which aesthetic discourse expresses affective states of mind, analogously to how assertions express beliefs. It is because these affective states require first-hand experience that aesthetic discourse communicates that such acquaintance is at hand. The paper furthermore argues that the lack of an experience requirement for aesthetic belief ascriptions constitutes a problem for the kind of expressivist who claims that evaluative belief states are covert non-cognitive states. (shrink)
Recent years have seen rapid progress in the development of ontologies as semantic models intended to capture and represent aspects of the real world. There is, however, great variation in the quality of ontologies. If ontologies are to become progressively better in the future, more rigorously developed, and more appropriately compared, then a systematic discipline of ontology evaluation must be created to ensure quality of content and methodology. Systematic methods for ontology evaluation will take into account representation of (...) individual ontologies, performance (in terms of accuracy, domain coverage and the efficiency and quality of automated reasoning using the ontologies) on tasks for which the ontology is designed and used, degree of alignment with other ontologies and their compatibility with automated reasoning. A sound and systematic approach to ontology evaluation is required to transform ontology engineering into a true scientific and engineering discipline. This chapter discusses issues and problems in ontology evaluation, describes some current strategies, and suggests some approaches that might be useful in the future. (shrink)
We use psychological concepts (e.g., intention and desire) when we ascribe psychological states to others for purposes of describing, explaining, and predicting their actions. Does the evidence reported by Knobe show, as he thinks, that moral evaluation shapes our mastery of psychological concepts? We argue that the evidence so far shows instead that moral evaluation shapes the way we report, not the way we think about, others' psychological states.
This article points out the criteria necessary in order for a qualitative scientific method to qualify itself as phenomenological in a descriptive Husserlian sense. One would have to employ description within the attitude of the phenomenological reduction, and seek the most invariant meanings for a context. The results of this analysis are used to critique an article by Klein and Westcott , that presents a typology of the development of the phenomenological psychological method.
Increasingly, the high throughput technologies used by biomedical researchers are bringing about a situation in which large bodies of data are being described using controlled structured vocabularies—also known as ontologies—in order to support the integration and analysis of this data. Annotation of data by means of ontologies is already contributing in significant ways to the cumulation of scientific knowledge and, prospectively, to the applicability of cross-domain algorithmic reasoning in support of scientific advance. This very success, however, has led to a (...) proliferation of ontologies of varying scope and quality. We define one strategy for achieving quality assurance of ontologies—a plan of action already adopted by a large community of collaborating ontologists—which consists in subjecting ontologies to a process of peer review analogous to that which is applied to scientific journal articles. (shrink)
Systems of logico-probabilistic (LP) reasoning characterize inference from conditional assertions interpreted as expressing high conditional probabilities. In the present article, we investigate four prominent LP systems (namely, systems O, P, Z, and QC) by means of computer simulations. The results reported here extend our previous work in this area, and evaluate the four systems in terms of the expected utility of the dispositions to act that derive from the conclusions that the systems license. In addition to conforming to the dominant (...) paradigm for assessing the rationality of actions and decisions, our present evaluation complements our previous work, since our previous evaluation may have been too severe in its assessment of inferences to false and uninformative conclusions. In the end, our new results provide additional support for the conclusion that (of the four systems considered) inference by system Z offers the best balance of error avoidance and inferential power. Our new results also suggest that improved performance could be achieved by a modest strengthening of system Z. (shrink)
Evaluative and normative terms and concepts are often said to be "essentially contestable". This notion has been used in political and legal theory and applied ethics to analyse disputes concerning the proper usage of terms like democracy, freedom, genocide, rape, coercion, and the rule of law. Many philosophers have also thought that essential contestability tells us something important about the evaluative in particular. Gallie (who coined the term), for instance, argues that the central structural features of essentially contestable concepts secure (...) their evaluativeness. I'll argue that these (widely held) central features are exemplified by many evaluative and non-evaluative terms alike, owing to more general factors (such as multidimensionality) which have nothing in particular to do with being evaluative. The role of these factors in semantic interpretation is subject to a certain kind of "metasemantic" disputes which have the features of the disputes characteristically admitted by essentially contestable concepts (whether evaluative or not) and which can be similarly substantive and worthwhile. In closing I'll discuss how my argument shows that our understanding of evaluative disagreement needs refinement. The overall upshot is that essential contestability shows nothing deep or distinctive about the evaluative in particular. (shrink)
The genre to which an artwork belongs affects how it is to be interpreted and evaluated. An account of genre and of the criteria for genre membership should explain these interpretative and evaluative effects. Contrary to conceptions of genres as categories distinguished by the features of the works that belong to them, I argue that these effects are to be explained by conceiving of genres as categories distinguished by certain of the purposes that the works belonging to them are intended (...) to serve. (shrink)
This chapter presents an alternative to the standard view that at least some of the evaluations that the so-called “thick” terms and concepts in ethics may be used to convey belong to their sense or semantic meaning. After introducing the topic and making some methodological remarks, the chapter presents a wide variety of linguistic data that are well explained by the alternative view that at least a very wide range of thick terms and concepts are such that even the evaluations (...) that are most closely connected to them are only a certain kind of defeasible implications of their utterances which can be given a conversational explanation. The chapter then describes some reasons to think that this explanation of the data presented is superior to the standard view, although a fuller assessment must await further work. The chapter closes by explaining the largely deflationary consequences of this account for claims that thick terms and concepts have deep and distinctive significance to evaluative thought and judgment. (shrink)
This paper explores the issue of epistemic injustice in research evaluation. Through an analysis of the disciplinary cultures of physics and humanities, we attempt to identify some aims and values specific to the disciplinary areas. We suggest that credibility is at stake when the cultural values and goals of a discipline contradict those presupposed by official evaluation standards. Disciplines that are better aligned with the epistemic assumptions of evaluation standards appear to produce more "scientific" findings. To restore (...) epistemic justice in research evaluation, we argue that the specificity of a discipline's epistemic aims, values, and cultural identities must be taken into account. (shrink)
I this article, I introduce the notion of pluralism about an area, and use it to argue that the questions at the center of our normative lives are not settled by the facts -- even the normative facts. One upshot of the discussion is that the concepts of realism and objectivity, which are widely identified, are actually in tension. Another is that the concept of objectivity, not realism, should take center stage.
It is a common view that arguments from analogy can only be evaluated on a case-by-case basis. However, while this reflects an important insight, I propose instead a relatively simple method for their evaluation based on just (i) their general form and (ii) four core questions. One clear advantage of this proposal is that it does not depend on any substantial (and controversial) view of similarity, unlike influential current alternative methods, such as Walton’s. Following some initial clarification of the (...) notion of analogy and similarity, I demonstrate the strength of this method by analysing and evaluating three prominent arguments from analogy. (shrink)
Generic statements express generalizations about categories. Current theories suggest that people should be especially inclined to accept generics that involve threatening information. However, previous tests of this claim have focused on generics about non-human categories, which raises the question of whether this effect applies as readily to human categories. In Experiment 1, adults were more likely to accept generics involving a threatening property for artifacts, but this negativity bias did not also apply to human categories. Experiment 2 examined an alternative (...) hypothesis for this result, and Experiments 3 and 4 served as conceptual replications of the first experiment. Experiment 5 found that even preschoolers apply generics differently for humans and artifacts. Finally, Experiment 6 showed that these effects reflect differences between human and non-human categories more generally, as adults showed a negativity bias for categories of non-human animals, but not for categories of humans. These findings suggest the presence of important, early-emerging domain differences in people's judgments about generics. (shrink)
We are pleased to publish this WSIA edition of Trudy’s Govier’s seminal volume, Problems in Argument Analysis and Evaluation. Originally published in 1987 by Foris Publications, this was a pioneering work that played a major role in establishing argumentation theory as a discipline. Today, it is as relevant to the field as when it first appeared, with discussions of questions and issues that remain central to the study of argument. It has defined the main approaches to many of those (...) issues and guided the ways in which we might respond to them. From this foundation, it sets the stage for further investigations and emerging research. This is a second edition of the book that is corrected and updated by the author, with new prefaces to each chapter. (shrink)
This paper addresses the following problem: to what extent do ontological considerations about musical works affect our evaluation of performances of those works? I argue for the claim that at least some important grounds on which performances are evaluated are specific to them, in that these grounds are either independent from, or related but not fully determined by, the properties of the works they are of. In the first part of the paper, I explore the relations between good-making features (...) of works and of performances of them. The second and third parts develop two kinds of example in favour of the claim above. In the last part, I discuss the significance of those examples in relation to the ways in which performances are assessed, and explore some further ramifications of them. (shrink)
This thesis examines philosophical controversies surrounding the evaluation of medical treatments, with a focus on the evidential roles of randomised trials and mechanisms in Evidence-Based Medicine. Current 'best practice' usually involves excluding non-randomised trial evidence from systematic reviews in cases where randomised trials are available for inclusion in the reviews. The first paper challenges this practice and evaluates whether adding of evidence from non-randomised trials might improve the quality and precision of some systematic reviews. The second paper compares the (...) alleged methodological benefits of randomised trials over observational studies for investigating treatment benefits. It suggests that claims about the superiority of well-conducted randomised controlled trials over well-conducted observational studies are justified, especially when results from the two methods are contradictory. The third paper argues that postulating the unpredictability paradox in systematic reviews when no detectable empirical differences can be found requires further justification. The fourth paper examines the problem of absence causation in the context of explaining causal mechanisms and argues that a recent solution is incomplete and requires further justification. Solving the problem by describing absences as causes of 'mechanism failure' fails to take into account the effects of absences that lead to vacillating levels of mechanism functionality . The fifth paper criticises literature that has emphasised functioning versus 'broken' or 'non-functioning' mechanisms emphasising that many diseases result from increased or decreased mechanism function, rather than complete loss of function. Mechanistic explanations must account for differences in the effectiveness of performed functions, yet current philosophical mechanistic explanations do not achieve this. The last paper argues that the standard of evidence embodied in the ICE theory of technological function is too permissive for evaluating whether the proposed functions of medical technologies have been adequately assessed and correctly ascribed. It argues that high-quality evidence from clinical studies is necessary to justify functional ascriptions to health care technologies. (shrink)
Many philosophers claim that interesting forms of epistemic evaluation are insensitive to truth in a very specific way. Suppose that two possible agents believe the same proposition based on the same evidence. Either both are justified or neither is; either both have good evidence for holding the belief or neither does. This does not change if, on this particular occasion, it turns out that only one of the two agents has a true belief. Epitomizing this line of thought are (...) thought experiments about radically deceived “brains in vats.” It is widely and uncritically assumed that such a brain is equally justified as its normally embodied human “twin.” This “parity” intuition is the heart of truth-insensitive theories of core epistemological properties such as justification and rationality. Rejecting the parity intuition is considered radical and revisionist. In this paper, I show that exactly the opposite is true. The parity intuition is idiosyncratic and widely rejected. A brain in a vat is not justified and has worse evidence than its normally embodied counterpart. On nearly every ordinary way of evaluating beliefs, a false belief is significantly inferior to a true belief. Of all the evaluations studied here, only blamelessness is truth-insensitive. (shrink)
This is a review essay devoted to Pekka Väyrynen’s The Lewd, the Rude and the Nasty. Väyrynen’s book, concerned with thick terms and thick concepts, argues for a pragmatic view on the evaluativeness associated with these terms and concepts. The essay raises a number of critical questions regarding what Väyrynen’s arguments for his view actually show. It deals with, for example, thick properties, the fact-value distinction, what it is for terms and concepts to be (semantically) evaluative, and whether Väyrynen’s arguments (...) generalize to thin evaluative concepts. (shrink)
Right after the elaboration and success of general relativity (GR), alternative theories for gravity began to appear. In order to verify and classify all these theories, specific tests have been developed, based on self-consistency and on completeness. In the field of experimental gravity, one of the important applications is formalism. For the evaluation of gravity models, several sets of tests have been proposed. Parameterized post-Newtonian formalism considers approximations of Einstein's gravity equations by the lowest order deviations from Newton's law (...) for weak fields. DOI: 10.13140/RG.2.2.25994.82881. (shrink)
Building upon the role values take in Walton’s theory of practical reasoning, this paper will frame the question of how values should be evaluated into the broader question of what reasonable practical argumentation is. The thesis argued for is that if a positive evaluation of practical reasoning argumentation requires that the argument avoid a morally negative conclusion, then the role of values should be given a central, rather than supportive, position in practical argument evaluation.
On a view implicitly endorsed by many, a concept is epistemically better than another if and because it does a better job at ‘carving at the joints', or if the property corresponding to it is ‘more natural' than the one corresponding to another. This chapter offers an argument against this seemingly plausible thought, starting from three key observations about the way we use and evaluate concepts from en epistemic perspective: that we look for concepts that play a role in explanations (...) of things that cry out for explanation; that we evaluate not only ‘empirical' concepts, but also mathematical and perhaps moral concepts from an epistemic perspective; and that there is much more complexity to the concept/property relation than the natural thought seems to presuppose. These observations, it is argued, rule out giving a theory of conceptual evaluation that is a corollary of a metaphysical ranking of the relevant properties. -/- conceptual ethics, explanation, naturalness, epistemic value, concept/property, semantic internalism. (shrink)
In her essay, “People and their Bodies,” Judith Thomson writes an evaluation of several formulations of the psychological criterion for personal identity and attempts a strategy of criticizing each formulation of the psychological theory. This is done in order to conclude that a physical theory must be the only remaining viable sufficient candidate for explaining personal identity that is both necessary and sufficient, despite its theoretical weaknesses. This paper seeks to analyze Thomson's critique and explain why her chosen formulations (...) of psychological criterion are inadequate and easy to refine against some of her rather hasty objections. In addition, counterarguments in favor of an 'impure' psychological criterion for personal identity are presented in the hopes of clarifying the philosophical discourse. (shrink)
We propose a multi-step evaluation schema designed to help procurement agencies and others to examine the ethical dimensions of autonomous systems to be applied in the security sector, including autonomous weapons systems.
This paper critically assesses the model of evaluation of scientific research for democratic societies defended by Philip Kitcher. The “significant truth” approach proposes a viable alternative to two classic images of science: that of the “critics”, who believe that science always serves the interests of the powerful and that of the “faithful”, who argue that the pursuit of scientific knowledge is always valuable and necessary. However, the democratic justification of Kitcher’s proposal is not compatible with the ethical problems generated (...) by the international biomedical research in developing countries. To overcome this problem, I revise the national democratic framing of the significant truth approach in light of the theory of justice of John Rawls. (shrink)
L'évaluation des écosystèmes est l'un des pivots essentiels pour l'élaboration de moyens adap- tés permettant de lutter contre la diminution massive de la biodiversité. Pour la première fois, elle a fait l'objet d'une analyse à l'échelle mondiale dans le cadre de l'Evaluation des écosys- tèmes en début de millénaire (EM). Le rassemblement de plus d’un millier de chercheurs et de plusieurs organismes internationaux durant quatre années ont permis de dessiner la carte nécessaire à toute action efficace. L'article expose les (...) éléments principaux de l'EM : l'évaluation des écosystèmes en tant que tels, mais surtout des services écosystémiques, dans toutes leurs dimensions, en ce que leur évolution affecte le bien-être humain. Il analyse ensuite les quatre points principaux de l'apport de l'EM, des avantages de l'utilisation croissante des services éco- logiques à sa non viabilité. Des scénarios, modèles et outils sont proposés pour inverser la courbe négative d'appauvrissement de la biodiversité et des services écosystémiques dans un premier bilan des retombées de l'EM. (shrink)
Individuals tend to judge bad side effects as more intentional than good side effects (the Knobe or side- effect effect). Here, we assessed how widespread these findings are by testing eleven adult cohorts of eight highly contrasted cultures on their attributions of intentional action as well as ratings of blame and praise. We found limited generalizability of the original side-effect effect, and even a reversal of the effect in two rural, traditional cultures (Samoa and Vanuatu) where participants were more likely (...) to judge the good side effect as intentional. Three follow-up experiments indicate that this reversal of the side-effect effect is not due to semantics and may be linked to the perception of the status of the protagonist. These results highlight the importance of factoring cultural context in our understanding of moral cognition. (shrink)
This study assessed quality assurance practices and students’ performance evaluation in universities of South-South Nigeria using an SEM approach. Three null hypotheses guided the study. Based on factorial research design, and using a stratified random sampling technique, a sample of 878 academic staff were drawn from a sampling frame of 15 universities in South-South Nigeria. Quality Assurance Practices Students’ Performance Evaluation Scale (QAPSPES) with split-half reliability estimates ranging from .86–.92, was used as the instruments for data collection. Multiple (...) regression and Confirmatory Factor Analyses (CFA) were used for the analysis of data, model building, and testing of the hypotheses at .05 alpha level. Findings showed a significant composite and relative influence (F=48.19, P<.05) of school management, staff, and students’ quality assurance practices on students’ performance evaluation. The results also indicated that there were positive and significant covariances between the four variables of this study, with the CFI, RMSEA, TLI, and SRMR values indicating a good model fit. It was recommended, based on the findings of this study that, each school should organize quality assurance orientation campaigns for new students and set up quality assurance committees at the school, faculty and departmental levels for optimal performance in schools. (shrink)
In this paper I challenge and adjudicate between the two positions that have come to prominence in the scientific realism debate: deployment realism and structural realism. I discuss a set of cases from the history of celestial mechanics, including some of the most important successes in the history of science. To the surprise of the deployment realist, these are novel predictive successes toward which theoretical constituents that are now seen to be patently false were genuinely deployed. Exploring the implications for (...) structural realism, I show that the need to accommodate these cases forces our notion of “structure” toward a dramatic depletion of logical content, threatening to render it explanatorily vacuous: the better structuralism fares against these historical examples, in terms of retention, the worse it fares in content and explanatory strength. I conclude by considering recent restrictions that serve to make “structure” more specific. I show however that these refinements will not suffice: the better structuralism fares in specificity and explanatory strength, the worse it fares against history. In light of these case studies, both deployment realism and structural realism are significantly threatened by the very historical challenge they were introduced to answer. (shrink)
Abstract: Use of antagonistic ability of Trichoderma spp. to control plant disease is an alternative disease management practice that protects the environment from the hazardous effect of the chemicals. Low density of population of Trichoderma spp. in the normal field is a challenge to gain best effect of antagonist over soil pathogens. Seven organic substrate treatments; compost, cow dung, paddy husk, paddy straw, coir dust, Gliricidia sepium and control were tested for multiplication and long-term survival of Trichoderma spp.. Three test (...) conditions; substrates mixed with soil, substrates without mixing in soil and substrates sterilized were used in the experiment. In addition the bio-fungicide powder applied as the inoculum of Trichoderma spp. was subjected for confirmation. The concentration of Trichoderma spp. (spores/ml) was counted by Hemocytometer and growth pattern was recorded throughout the study. The Blister Blas was confirmed to contain of Trichoderma spp. inoculum. Among the conditions substrates mixed with soil and sterilized substrates had similar effect. A significant effect on growth of Trichoderma spp. was shown between treatments. Substrates compost and paddy husk recorded highest multiplication of Trichoderma spp. in all three conditions. Coir dust was not successful in multiplying Trichoderma spp. which recorded lower results than the control. The cost of application for compost stands greater than paddy husk. Therefore, paddy husk was the affordable organic substrate for farmers that could be applied in fields in order to multiply Trichoderma spp. in soil. (shrink)
The physico-chemical condition of water and soil plays a vital role in the wetland ecosystem. Three sampling stations were selected for the study of physico-chemical parameters of water and soil of Guthia taal in relation to fish production. Various physico-chemical parameters of water like temperature, transparency, pH, dissolved oxygen, free carbon dioxide, biochemical oxygen demand, chemical oxygen demand, total alkalinity, total hardness, nitrate and phosphate were measured. The soil samples were analysed with respect to soil texture, pH, organic carbon, available (...) phosphorus and nitrogen. The present finding established that, in spite of fevourable physico-chemical condition of water and soil, potential fish yield is not being realized. Fish production can be augmented to a great extent if we managed scientifically. It can be realized optimally by stocking of fast growing Indian major carps (Catla, Rohu, Mrigal and Calbasu) and Exotic carps @ 1000- 1500 fingerlings/ha to utilize all the available fish food resources. (shrink)
In Winter 2017, the first author piloted a course in formal logic in which we aimed to (a) improve student engagement and mastery of the content, and (b) reduce maths anxiety and its negative effects on student outcomes, by adopting student oriented teaching including peer instruction and classroom flipping techniques. The course implemented a partially flipped approach, and incorporated group-work and peer learning elements, while retaining some of the traditional lecture format. By doing this, a wide variety of student learning (...) preferences could be provided for. (shrink)
The Jinn, which is regarded as the third kind of entity apart from the angel and the human being, has been the subject matter of several separate works written by both Muslims and non-Muslims in the past and present. In short, such works deal with the nature of jinns and their characteristics, and they cover matters such as the beliefs about jinns in several religions and cultures and their relationship with human beings. Apart from the fact that the primary source (...) of Islam, namely, the Quran, has a separate chapter called al-Jinn (The Jinn) /72, it provides information about jinns in many verses in several other chapters. Traditions also provide plenty of information about jinns. One example of such information is on the question whether the Holy Prophet have met with jinns. A study of the traditions on this matter reveals the fact that there are ṣaḥīḥ (authentic) traditions that appear to be in conflict with each other and/or with some of the verses in the Quran. In this paper, we have analyzed and evaluated the relevant traditions in order to reconcile these contradictions, thus we aimed to clarify the matter. The question on whether the Holy Prophet met with jinns is often discussed within the context of narrations coming from Ibn al-Masʿūd and Ibn ʿAbbās. While the traditions coming from Ibn al-Masʿūd indicate that the Prophet met with jinns, a tradition narrated by Ibn ʿAbbās says the opposite. In the present work, we have analyzed the outwardly conflicting traditions narrated by both companions along with traditions narrated by other companions on this matter in the light of the chronology of the revelation of the Quran. As a result, we have concluded that the Holy Prophet have met with jinns as narrated by Ibn al-Masʿūd and that the report narrated by Ibn ʿAbbās was about the first years of Islam. (shrink)
What is the aim of philosophy? There may be too many philosophical branches, traditions, practices, and programs to admit of a single overarching aim. Here I focus on a fairly traditional philosophical project that has recently received increasingly sophisticated articulation, especially by Frank Jackson (1998) and David Chalmers (2012). In §1, I present the project and suggest that it is usefully thought of as ‘total axiomatics’: the project of attempting to axiomatize the total theory of the world. In §2, I (...) raise a problem for the project that I call the ‘problem of multiple axiomatizations.’ I consider some initially alluring but ultimately unpromising approaches to this problem in §3. In §4, I defend a surprising approach to the problem, according to which competing axiomatizations of the total theory of the world are effectively evaluated for their aesthetic virtues. (shrink)
Adults aged 65 and above comprise the fastest growing sector of the world’s population. In the context of increasing numbers of older adults, employment policies have become a prominent issue. Governments recognize the importance of increasing participation in working age population and providing them with equal workplace opportunities. Yet, it appears that policies raising employment rates of older adults have become a slogan that governments use for election purposes, but the reality is different. In the groundbreaking report “Working Better with (...) Age: Poland‘ prepared by the Organization for Economic Cooperation and Development, Poland, the Czech Republic, and Slovakia belong to a group of countries where the increase in the employment rate of older adults is well below the OECD average. The objective of our critical review is to evaluate current employment policies for older adults, including but not limited to healthy work conditions, age management strategies, employment services for older workers, and strategies implemented to prevent the age discrimination, in these three countries. This article also discusses the reasons for the reduction in the employment of older adults, the current barriers in employing older adults that require governments’ attention, and suggests solutions for creating an age-friendly labor market that can effectively make use of older adults’ competencies. Employment rates for people of different ages are significantly affected by government policies with regard to higher education, pensions, and retirement age. (shrink)
Backgound: The aims of this study were to evaluate the antimicrobial properties and synergistic effects of nano-titanium dioxide (TiO2), nano- zinc oxide (ZnO) and two synthetic peptides (mastoparan-B, indolicidin) against drug-resistant strains of Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii. -/- Methods: From March to August 2015, a total of 30 (10 each) isolates of the above bacteria were recovered from patients in the ICU of two referral hospitals in Kerman, Iran. The sizes and purities of nano-TiO2, nano-ZnO were determined (...) by scanning electron microscope (SEM) and X-ray diffraction (XRD). Similarly, mass spectroscopy and HPLC were used for checking the genunity of the peptides. Antibiotic sensitivity was determined by agar disk diffusion assay. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) activities of nanometals and synthetic peptides were assessed by CLSI broth microdilution test. Similarly, checkerboard and time-kill curve analysis were performed to determine the synergistic activities of these compounds. -/- Results: Mastoparan-B had potent toxicity to all isolates with an average MIC 4 ± 0.2 mg/L, while TiO2-NP had lowest antimicrobial activity with MIC range 1280 ≥ ± 0.2 mg/L (P. aeruginosa growth was not inhibited by TiO2 and ZnO NPs). The bactericidal activity against the isolates in descending order was mastoparan-B, indolicidin, nano ZnO, and nano TiO2, respectively. Further investigation on synergism using fractional inhibitory concentration index (FIC) revealed that, nano-TiO2 and nano-ZnO combination had an additive effect (FIC = 0.95 ± 0.1) on A. baumannii and K. pneumoniae strains, whereas, P. aeruginosa isolates were indifferent to this combination (FIC ≥ 2 ± 0.2). In contrast, mastoparan-B and indolicidin combination displayed broad synergistic effect (FIC = 0.5 ± 0.1) on all the isolates and caused rapid killing of the organisms within 4 h of incubation. -/- Conclusions: Our results showed that the combination of mastoparan-B and indolicidin peptides is a suitable candidate for substitution of the antibiotics for topical treatment of infections caused by drug- resistant bacteria. (shrink)
Introduction: Universal health coverage (UHC) was introduced in Iran in 2014. The aim of this study was to evaluate the usage rate of health services by human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients after UHC implementation. Material and methods: In 2018, in a cross-sectional study, we evaluated the outpatients’ needs (within its previous month) and inpatients’ needs (within its previous 6 months) of HIV/AIDS patients in Isfahan province (the center of Iran). Concurrently, we estimated the essential health care services (...) that HIV/AIDS patients have to receive regularly, including vaccination for hepatitis B, measurement of CD4, tuberculosis (TB) assessments and TB treatment, anti-retroviral therapy, examination of viral load, treatment approach, and drug side effects counseling. Two checklists were used for assessing the utilization of health services and essential health cares for HIV/AIDS patients, validated by the Ministry of Health and Medical Education of Iran. Data were analyzed by χ2 test, Pearson’s correlation coefficient, and Spearman’s correlation test. Results: Two hundred and thirteen HIV/AIDS patients completed the questionnaires. The mean age of participants was 41.14 ± 9.23. The outpatient service utilization rate was 31.94% in the previous month and the rate of hospitalization was 126 per 1,000 HIV/AIDS patients in the previous 6 months. The majority of HIV/AIDS patients received essential health services more often than the national standard goals estimation. Conclusions: After UHC implementation, the utilization rate of outpatients and inpatients services in HIV/AIDS patients was more than similar indices in the general population. In addition, HIV/AIDS patients received essential health services adequately. (shrink)
Prophet (pbuh) has given notice that the Salah [prayer] is the first deed in which the Muslim servant will be brought to account on the Day of Judgement. The Prophet (pbuh) also informed that if the believer’s obligatory (fardh) prayers are lacking this will be made up from voluntary (nawafil) prayers and that the servant comes close to Allah by fulfilling obligatories and continues to draw near to him with voluntary deeds. One of nawafil is the prayer which is performed (...) before and after the obligatory Friday prayer. When we examine the Prophetic narrations about those prayers -which is also called the first and the second sunnah- and their authenticity, we witness that the Prophet (pbuh) performed prayers in differing raka’ah numbers after the obligatory Friday prayer and urged to it, but there is no authentic and clear traditon indicating that He (pbuh) perfomed any prayer before it. However, by taking into account some general statements of Prophet (pbuh), some weak narrations and some practices of companions it has been said that the Friday prayer has a sunnah before it and moreover it is a Sunnah Muakkadah (stressed sunnah) which is performed in two or four raka’ahs. This article aims to present the narrations about whether the Prophet (pbuh) and companions used to perform any prayers before and after the obligatory Juma’ prayer and their number of raka’s, to determine their authenticity and to evaluate them by reporting the comments about them. (shrink)
Some patients with a lesion to the striate cortex (V1), when assessed through forced-choice paradigms, are able to detect stimuli presented in the blind field, despite reporting a complete lack of visual experience. This phenomenon, known as blindsight, strongly implicates V1 in visual awareness. However, the view that V1 is indispensable for conscious visual perception is challenged by a recent finding that the blindsight subject GY can be aware of visual qualia in his blind field, implying that V1may not be (...) critical under all circumstances. This apparent contradiction raises the following question: if V1 is not always necessary for phenomenal awareness, why do V1 lesions have such a detrimental effect on conscious perception? It is suggested here that this contradiction can be resolved by considering the impact of V1 lesions on the functioning of the whole visual cortex. (shrink)
In an important discussion of the problem of hiddenness, Michael Rea briefly presents and defends an argument from divine hiddenness which he thinks encapsulates the problem of divine hiddenness, and then develops a detailed and nuanced response to this argument. Importantly, Rea claims that his response does not depend on the commonly held theistic view that God allows hiddenness to secure human goods. In this paper I offer a detailed criticism of Rea’s account of what justifies God in allowing divine (...) hiddenness, arguing that Rea’s response to the argument from divine hiddenness is unsuccessful. (shrink)
ABSTRACT This paper explores the role of aesthetic judgements in mathematics by focussing on the relationship between the epistemic and aesthetic criteria employed in such judgements, and on the nature of the psychological experiences underpinning them. I claim that aesthetic judgements in mathematics are plausibly understood as expressions of what I will call ‘aesthetic-epistemic feelings’ that serve a genuine cognitive and epistemic function. I will then propose a naturalistic account of these feelings in terms of sub-personal processes of representing and (...) assessing the relation between cognitive processes and certain properties of the stimuli at which they are directed. (shrink)
In chapter 7 of The Varieties of Reference, Gareth Evans claimed to have an argument that would present "an antidote" to the Cartesian conception of the self as a purely mental entity. On the basis of considerations drawn from philosophy of language and thought, Evans claimed to be able to show that bodily awareness is a form of self-awareness. The apparent basis for this claim is the datum that sometimes judgements about one’s position based on body sense are immune to (...) errors of misidentification relative to the first-person pronoun 'I'. However, Evans’s argument suffers from a crucial ambiguity. 'I' sometimes refers to the subject's mind, sometimes to the person, and sometimes to the subject's body. Once disambiguated, it turns out that Evans’s argument either begs the question against the Cartesian or fails to be plausible at all. Nonetheless, the argument is important for drawing our attention to the idea that bodily modes of awareness should be taken seriously as possible forms of self-awareness. (shrink)
How we evaluate things and what we desire are closely connected. In typical cases, the things we desire are things that we evaluate as good or desirable. According to evaluation theories of desire, this connection is a very tight one: desires are evaluations of their objects as good or as desirable. There are two main varieties of this view. According to Doxastic Evaluativism, to desire that p is to believe or judge that p is good. According to Perceptual Evaluativism, (...) to desire that p is to perceive p as being good (or for p to seem good). The present paper poses a puzzle for such views. The puzzle should be familiar to theorists interested in the normativity and metaphysics of the emotions, but I am unaware of its application to desire. The aim of the present paper is to present the puzzle as it applies to desire, which should be of independent interest, but I also hope that by shining a light on the puzzle in this domain, we might put ourselves in a better position to offer a solution in all cases. At the end of the paper, I gesture towards a promising way ahead that departs from relying on contradictory contents. (shrink)
This paper examines how different forms of performance evaluation relate to aspects of the creative climate in a major pharmaceutical company. The study was based on a large employee-attitude survey that was distributed to all company employees. The study analyses survey results from 5,333 employees at five R&D sites. The results indicate that management’s evaluation of employees (either dialogue-based or control-based) relates to the type of motivation (intrinsic or extrinsic) that drives employees, to their style of thinking (value-focused (...) thinking) and on their attitudes to organizational creativity. The paper then discusses implications of these findings for HRM. (shrink)
Maintaining systems of military plans is critical for military effectiveness, but is also challenging. Plans will become obsolete as the world diverges from the assumptions on which they rest. If too many ad hoc changes are made to intermeshed plans, the ensemble may no longer lead to well-synchronized and coordinated operations, resulting in the system of plans becoming itself incoherent. We describe in what follows an Adaptive Planning process that we are developing on behalf of the Air Force Research Laboratory (...) (Rome) with the goal of addressing problems of these sorts through cyclical collaborative plan review and maintenance. The interactions of world state, blue force status and associated plans are too complex for manual adaptive processes, and computer-aided plan review and maintenance is thus indispensable. We argue that appropriate semantic technology can 1) provide richer representation of plan-related data and semantics, 2) allow for flexible, non-disruptive, agile, scalable, and coordinated changes in plans, and 3) support more intelligent analytical querying of plan-related data. (shrink)
Whereas there is extensive documentation that attribute framing influences the content of peoples thought, we generally know less about how it affects the processes assumed to precede those thoughts. While existing explanations for attribute framing effects rely completely on valence-based associative processing, the results obtained in the present study are also consistent with the notion that negative framing stimulates more effortful and thorough information processing than positive framing. Specifically, results from a simulated business decision-making experiment showed that decision makers receiving (...) negatively framed information had significantly better recall than those receiving positively framed information. Furthermore, decision makers in the negative framing condition were less confident than decision makers in the positively framed condition. Finally, compared to a no-framing condition, decision makers receiving positive framing deviated significantly more in evaluation than decision makers receiving negative framing did. (shrink)
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