In recent years, technology has evolved significantly to intervene in the treatment of diseases through diagnosis online before going to the specialist doctor, where it become possible for the patient to know the name of his illness, the specialist doctor who can treat him and the multiple treatment methods through specially designed systems called expert systems. The expert system is based on the principle of asking the user gradual questions about the symptoms he feels, leading him to the result of (...) diagnosing the illness, dealing with it quickly, and tips for permanent treatment. These systems may also help both trainee physicians and physiotherapists. This research paper is a living example of these effective applications, explaining in a simplified manner some of ankle diseases, how to deal with them and methods of physical therapy. The ankle is a small region in the leg. It is two joints, the first consist of three bones (tibia, fibula and talus underneath) which is called true ankle joint. The other is called subtalar joint have two bones: talus on top and calcaneus on the bottom. This tarsus between the end of the leg and the start of the foot facilitates the movement up-down and left-right with no problems in normal case, although, it needs a special case as Physiotherapist when gets injury. We have identified seven ankle diseases: Ankle Sprain, Fracture (of Fibula), Rheumatoid Arthritis, Rheumatoid Fever, Gout, and Osteoarthritis (Degenerative Joint) using SL5 Object Expert System Language in the work of the expert system. (shrink)

A number of experiences have demonstrated how digital solutions are effective in improving quality of life (QoL) and health outcomes for older adults. Smart Health Age-Friendly Environments (SHAFE) is a new concept introduced in Europe since 2017 that combines the concept of Age-Friendly Environments with Information Technologies, supported by health and community care to improve the health and disease management of older adults and during the life-course. This chapter aims to provide an initial overview of the experiences available not only (...) in Europe, based on the research work of the participants of the International Interdisciplinary Network on Health and Well-being in an Age-Friendly Digital World (NET4Age-Friendly), which could be of interest to preventive, health and social authorities. The chapter reports good practices, pain points, and bottlenecks that may require a collaborative, interdisciplinary research approach to facilitate the transformations towards smart, sustainable, health and age-friendly cities and communities. (shrink)

Bone Fractures are a prevalent clinical condition that necessitates and timely diagnosis. Conventional manual identification of fractures from X-ray images is slow and error-prone. In response to these issues, this paper introduces a deep learning approach for automated detection and classification of bone fractures. A Convolutional Neural Network (CNN) model was implemented and trained on an X-ray image dataset, using data augmentation methods to improve generalization and avoid overfitting. The suggested model was tested with various experimental configurations, such as cross-validation (...) and showed better performance than current state-of-the-art techniques. Adam optimizer helped achieve better classification accuracy than traditional methods. Additional improvements, including sophisticated augmentation methods, transfer learning and ensemble models, may enhance predication accuracy. This research underscores the potential of deep learning in medical imaging for precise and computerized fracture identification, lowering diagnosis time and enhancing patient outcomes. (shrink)

Abstract— Anatomy of the anterior compartment includes the tibia and the fibula. It also includes the tibialis anterior tendon, the extensor hallucis longus tendon and the extensor digitorum longus tendons. The anterior tibial artery and the deep peroneal nerve and finally the superior and inferior extensor retinaculum. In this paper an expert system was designed to help users to correctly diagnose ankle problems. There are many structures present at the anterior aspect of the ankle; these structures are often (...) susceptible to injury common injuries and conditions around the anterior ankle. Clips expert system language was used to design and implement this expert system. (shrink)

More number of deaths occurring every year due to a common health issue, cancer. It is one of the diseases distributed over large areas. Among all, bone cancer is most predominant, having a high death rate. Hence this is most important and a lot of research is going on and to identify bone cancer X-RAY scanned images are used. They provide a picture detailed with the growth of the tumor and track its growth in the body so it is better (...) by providing good results compared to other techniques. Therefore in medical fields most of the image processing techniques are used to detect cancer in its early stages .In this project we present an approach to detect bone cancer in scanned images. The steps involved in it are proposed using methods of image preprocessing where median filter is used followed by segmentation where mathematical morphological operations are used. Geometrical features like area, perimeter, and eccentricity are calculated to the tumor detected part. At last CNN classifier is used to classify whether it is cancerous (Malignant) or normal (Benign). In our project we will be using the following algorithms for classification like Support Vector Machine (SVM) as existing and Convolution Neural Network (CNN) as proposed and its accuracy has been calculated and well compared. From the results obtained it is proved that the proposed Convolution Neural Network (CNN) performs better than existing Support Vector Machine (SVM). (shrink)

In 2011, a 5,000-year-old “male” skeleton buried in a “female” way was discovered by an archaeological team just outside of modern-day Prague. This article queries the impulse to name such a discovery as evidence of transgender identity, and bodies, in an increasingly ancient past. To do so, it takes up the work of Denise Ferreira da Silva, Sylvia Wynter, and Hortense Spillers as a means to push back against the impetus to name such discoveries “transgender” in order to shore up (...) the legitimacy of contemporary trans identity. Each of these three thinkers offers a different vantage point for rethinking such naming practices that push the reader to consider how desires to name and place “transgender” in a distant past papers over the violence of plantation slavery, global imperialism, and the Enlightenment's shift toward scientific reason. This article argues not that such anthropological discoveries should not be considered transgender, but rather that the desire for them to be, or become, transgender does not legitimate contemporary transgender identity, and may instead treat certain iterations of transness as spatially and temporally universal. (shrink)

A World of Muscle, Bone & Organs: Research and Scholarship in Dance is an e-book exploring contemporary ideas and themes in the research and practice of dance. It contains 23 chapters written by researchers at the Centre for Dance Research (C-DaRE), Coventry University, and is divided into six sections: Spaces of Practice, Philosophy, Communities, Politics, Data and Thinking, and Epistemology.

In Massachusetts, a proposed bill would reduce the sentence of those incarcerated who become living donors of either organs or bone marrow. We outline two concerns with such a proposal, which relate directly to the content of the proposal (as opposed to broader debates about payment for organs and validity of consent obtained from the incarcerated). The first of these concerns is about equality of opportunity. The proposal provides the opportunity for a sentence reduction for some but not for others (...) – and the distribution of these opportunities reflects circumstances largely beyond the control of the incarcerated. The second concern is that the proposal may conflict with why we punish in the first place. The proposal is at odds with the non-consequentialist general deterrence defended by Tadros, retributivism, and communicative theories of punishment. Among the theories examined, only the purely consequentialist version of general deterrence might find the practice palatable. The upshot of the latter observation is that the proposal presupposes the truth of a purely consequentialist theory of punishment and sets aside others. (shrink)

In this experimental investigation the Aluminium 6063 is treated with Aluminium Oxide (Al2O3) and Chicken Bone Ash (CBA). This Aluminium metal matrix composite is mixed at certain compositions and observed with the mechanical properties. Two main mechanical properties which includes Surface roughness and corrosion behavior is mainly focused in this research work. In this Research work aluminium hybrid metal matrix composite (AHMMC) is fabricated through stir casting process. Al6063 shows good mechanical properties and corrosion behavior changes, when combined with reinforcements, (...) Al2O3 and Chicken Bone Ash (CBA). Stir casting is an efficient cycle for the manufacture of aluminum hybrid composites. There are numerous boundaries in this cycle, which influence the behavior of corrosion and mechanical properties of the composites. Stir casting is a fluid state technique for the manufacture of composite materials, in which a scattered stage is blended in with a liquid network metal by methods for mechanical mixing. Stir Casting is the least difficult and the most financially savvy strategy for fluid state manufacture. Finally in this research work, when the compositions of each and every reinforcement increase, simultaneously the surface roughness of the composite also get increases. (shrink)

Objective: The present study aims to determine the number and position of the nutrient foramina (NF) of the human femur, tibia, and fibula and to observe the size, direction, and obliquity of the nutrient foramina. Methods: We observed 265 adult human, lower limb long bones in the Department of Anatomy of the Gaziantep University. The nutrient foramina were identified with naked eyes, and the obliquity was determined with a hypodermic needle. Gauge 20 and 24 needles were used for size (...) determination. Shape was observed with the naked eye and classified into oval and round types. The nutrient foramina location was determined by dividing total bone length into three segments, and the locations were validated by calculating foraminal index (FI). Results: Results showed that 79% of the long bones had a single nutrient foramen. More than 96% of the nutrient foramina were directed away from the knees. A total of 87% of the femoral foramina were located in the middle third, 72% of the tibial foramina were located in the proximal third, and 98% of the fibular nutrient foramina were located in the middle third of the specimens. Overall, no foramina were found on the distal third of the studied bones. Conclusion: Our study findings are in accordance to the findings from several research studies. The assessment of pathological conditions associated with the findings of foramen nutricium in our study may help clinicians and surgeons in planning treatments for applications to be performed in this region. However, it is thought that literature will be a source for basic and clinical sciences by providing reference values. (shrink)

Objectives: The most principal nutrition source of a bone is nutrient arteries. They are important at every stage of bone development. A nutrient artery enters a bone through the nutrient foramen, the largest hole on the outer surface of the bone. The foramen is important both morphologically and clinically. -/- Methods: A total of 414 adult human dry bones were investigated in this study to identify topographic and morphological features of nutrient foramina in the scapula, clavicle, humerus, radius and (...) ulna. Nutrient foramina were examined with a hand lens. Their dimensions and directions were determined with a 21-gauge needle, and thus major foramina were detected. Positions of nutrient foramina were noted according to surfaces of the bones, and to segments separated as proximal, middle and distal by calculating foraminal index. -/- Results: A single nutrient foramen was found in 71% of our samples. We observed that 94.2% of foramina in the clavicle, 89.3% of foramina in the humerus, 51.3% of foramina in the radius, and 67.7% of foramina in the ulna were located in the middle 1/3 segment of the bones. -/- Conclusion: Our findings were in line with the data in the literature. On account of pathologies associated with the nutrient foramen, our findings may be helpful for surgeons to design applications performed in the region. In addition, we think that our data by contributing to the literature may be a resource for clinicians due to the importance of the nutrient foramen for surgical procedures. (shrink)

Good sciences have good metaphors. Indeed, good sciences are good because they have good metaphors. AI could use more good metaphors. In this editorial, I would like to propose a new metaphor to help us understand intelligence. Of course, whether the metaphor is any good or not depends on whether it actually does help us. (What I am going to propose is not something opposed to computationalism -- the hypothesis that cognition is computation. Noncomputational metaphors are in vogue these days, (...) and to date they have all been equally plausible and equally successful. And, just to be explicit, I do not mean “IQ” by “intelligence.” I am using “intelligence” in the way AI uses it: as a semi-techical term referring to a general property of all intelligent systems, animal (including humans), or machine, alike.). (shrink)

Parents are usually appreciated as possessing legitimate moral authority to compel children to make at least modest sacrifices in the service of widely shared values of moral decency. This essay argues that such authority justifies allowing parents to authorize a child to serve as an organ or tissue donor in certain circumstances, such as to authorize bone marrow donations to save a sibling with whom the potential donor shares a deep emotional bond. The approach explored here suggests, however, that at (...) least under some conditions, parents have legitimate authority to authorize donations forbidden by current guidelines. (shrink)

Objective: Atlas is located at a critical point close to the vital centers of the medulla oblongata, which can be compressed by the dislocation of the atlantoaxial complex or instability of the atlantooccipital joint. This study aimed to determine in detail the morphometric and morphological characteristics of the atlas to guide the reduction of the risk of complications and increase the success rate in various surgical approaches for the craniovertebral junction. -/- Methods: In this study, 17 atlas vertebrae whose measurement (...) parameters were pronounced and unknown gender, age, and ethnic characteristics were examined. -/- Results: Totally 16 parameters, 11 of which were bilateral and 5 were unilateral, were examined on the atlas. Also, no accessory foramen transversarium was found in these atlas vertebrae. Of the 23 foramina transversaria that were prominent and not broken, 7 were found to be round-shaped (30.43%), and 16 were oval-shaped (69.57%). -/- Conclusion: It is deducted that the results obtained in this study will help to have information about the morphometry and morphology of atlas vertebrae. Although information such as age, gender, and ethnic origin is not known about the bones evaluated, it is the advantage of this study that a large number of parameters are evaluated and compared with previous publications. Nevertheless, it seems that there is a need for studies in which much more cases are assessed, and information such as age, gender, and ethnic origin is known. (shrink)

Pain, crucially, is unpleasant and motivational. It can be awful; and it drives us to action, e.g. to take our weight off a sprained ankle. But what is the relationship between pain and those two features? And in virtue of what does pain have them? Addressing these questions, Colin Klein and Richard J. Hall have recently developed the idea that pains are, at least partly, experiential commands—to stop placing your weight on your ankle, for example. In this paper, (...) I reject their accounts. Against Klein, I use dissociation cases to argue that possession of ‘imperative content’ cannot wholly constitute pain. Against them both, I further claim that possession of such content cannot even constitute pain’s unpleasant, motivational aspect. For, even if it were possible to specify the relevant imperative content—which is far from clear—the idea of a command cannot bear the explanatory weight Klein and Hall place on it. (shrink)

The following bare-bones story introduces the idea of a cumulative hierarchy of pure sets: 'Sets are arranged in stages. Every set is found at some stage. At any stage S: for any sets found before S, we find a set whose members are exactly those sets. We find nothing else at S.' Surprisingly, this story already guarantees that the sets are arranged in well-ordered levels, and suffices for quasi-categoricity. I show this by presenting Level Theory, a simplification of set (...) theories due to Scott, Montague, Derrick, and Potter. (shrink)

The debate between realists and anti-realists about fictional entities is important partly because it connects with debates about the nature of reference. According to the descriptivist model held by Fregeans, a name has reference to an object due to the connection of that name with a description, which is met by the relevant object. According to the causal-communicative model held by Millians, a name refers in virtue of a chain of reference linking that name to a referent. In the case (...) of fictional entities, it is a matter of debate whether the entities in question exist or not. Traditionally, Millians have had trouble dealing with antirealism about fictional entities. I argue for a simple realist theory, ‘bare-bones artifactualism’, according to which fictional entities are simple abstract ‘counters’. Each of these simple abstract counters has only those intrinsic properties that other such simple abstract counters also have, except for one distinctive intrinsic property. This one distinctive intrinsic property is a number-bearing property that marks out the abstract counter’s identity, distinct from all other such abstract counters. The number-bearing property allows us to do with abstract counters what spatiotemporal situatedness allows us to do with concrete counters: it allows us to treat the abstract counters as individuals. In support of such artifactualism, I discuss the following considerations: its ontological simplicity; its parallels in our other practices; and its explanatory promise. (shrink)

l argue that, contra Chalmers,a skeptical scenario involving deception is a genuine possibility,even if he is correct that simulations are real. I call this new skeptical position “Illusory World Skepticism.” Illusory World Skepticism draws from the simulation argument,together with work in physics,astrobiology, and AI,to argue that we may indeed be in an illusory world—a universe scale simulation orchestrated by a deceptive AI—the technophilosopher’s ultimate evil demon. In Section One I urge that Illusory World Skepticism is a bone fide skeptical possibility. (...) In Section Two, I explore features of quantum computation. Then, in Sections Three and Four, I draw from the discussion of quantum computation and assume that the simulation argument is correct,applying considerations from the fields of astrobiology and AI safety to illustrate that illusory world skepticism constitutes what I call “a serious epistemic threat”, a scenario that cannot be dismissed as requiring that knowledge is certainty or which seems to just depict a remote, fictional situation. (shrink)

Consciousness has been the bone of contention for philosophers throughout centuries. Indian philosophy largely adopted lived experience as the starting point for its explorations of consciousness. For this reason, from the very beginning, experience was an integral way of grasping consciousness, whose validity as a tool was considered self-evident. Thus, in Indian philosophy, the question was not to move from the brain to mind but to understand experience of an individual and how such an experience is determined through mental structures (...) (and secondarily, the preoccupation with the brain and its relation to the mind). In contrast, cognitive science (the study of mind and cognition through 1 interdisciplinary methods, with emphasis on computational methods) found its debates soaked in discussion which primarily involved the brain and mind. Experience was not considered a primary source of information and its validity had to be established to consider it a source of information of mind. With the rise of physicalism and realization that mental states are correlative to brain states, the body was virtually neglected from involvement in understanding the mind and the attempts to reduce mind to the brain were rampant. The inability to explain subjective experience of an individual through neuroscientific findings alone has urged philosophers to explore other ways of understanding the ontology of mind. Over the last few years, embodied cognition and enactive approach have brought back the body as a central participant in this debate, providing fertile grounds to explain the relation of brain, body and mind. This paper proposes that we understand the brain as a complex system from which the mind emerges. This emergence is marked by the development of novel property of self-consciousness in human beings. The mind is a process which is embedded throughout the body and thus, the body acts as an actualizing medium for the individual. Thus, the brain is a necessary condition for the mind to be while the mind is embedded throughout the body. The brain and mind are in reciprocal causal relationship with one another, as is the body and environment with one another. In this paper, embodied cognition is understood through principles of Merleau Ponty's idea of embodiment, than through Andy Clark and Francis Varela's alone. (shrink)

Your belief that Obama is a Democrat would not be the belief that it is if it did not represent Obama, nor would the pain in your ankle be the state that it is if, say, it felt like an itch. Accordingly, it is tempting to hold that phenomenal and representational properties are essential to the mental states that have them. But, as several theorists have forcefully argued (including Kripke (1980) and Burge (1979, 1982)) this attractive idea is seemingly (...) in tension with another equally attractive thesis, namely, the token-identity thesis; the thesis according to which every mental state token is identical with some or other token physical state. In this paper, we show that these seemingly incontrovertible essentialist intuitions are in fact compatible with “token physicalism” regarding the mental. Given a suitably plentitudinous ontology of objects, we argue that there are physical things with which our token mental states can be identified. This is preferable to existing views that give up the essentiality claims or simply reject the token-identity thesis. (shrink)

In this paper an Artificial Neural Network (ANN) model, for predicting the category of a tumor was developed and tested. Taking patients’ tests, a number of information gained that influence the classification of the tumor. Such information as age, sex, histologic-type, degree-of-diffe, status of bone, bone-marrow, lung, pleura, peritoneum, liver, brain, skin, neck, supraclavicular, axillar, mediastinum, and abdominal. They were used as input variables for the ANN model. A model based on the Multilayer Perceptron Topology was established and trained using (...) data set which its title is “primary tumor” and was obtained from the University Medical Centre, Institute of Oncology, Ljubljana, Yugoslavia Test data evaluation shows that the ANN model is able to correctly predict the tumor category with 76.67 % accuracy. (shrink)

Supervaluationism is often described as the most popular semantic treatment of indeterminacy. There’s little consensus, however, about how to fill out the bare-bones idea to include a characterization of logical consequence. The paper explores one methodology for choosing between the logics: pick a logic thatnorms beliefas classical consequence is standardly thought to do. The main focus of the paper considers a variant of standard supervaluational, on which we can characterizedegrees of determinacy. It applies the methodology above to focus ondegree (...) logic. This is developed first in a basic, single-premise case; and then extended to the multipremise case, and to allowdegreesof consequence. The metatheoretic properties of degree logic are set out. On the positive side, the logic is supraclassical—all classical valid sequents are degree logic valid. Strikingly, metarules such as cut and conjunction introduction fail. (shrink)

In various documents the view emerges that contemporary biotechnosciences are currently experiencing a scientific revolution: a massive increase of pace, scale and scope. A significant part of the research endeavours involved in this scientific upheaval is devoted to understanding and, if possible, ameliorating humankind: from our genomes up to our bodies and brains. New developments in contemporary technosciences, such as synthetic biology and other genomics and “post-genomics” fields, tend to blur the distinctions between prevention, therapy and enhancement. An important dimension (...) of this development is “biomimesis”: i.e. the tendency of novel technologies and materials to mimic or plagiarize nature on a molecular and microscopic level in order to optimise prospects for the embedding of technological artefacts in natural systems such as human bodies and brains. In this paper, these developments are read and assessed from a psychoanalytical perspective. Three key concepts from psychoanalysis are used to come to terms with what is happening in research laboratories today. After assessing the general profile of the current revolution in this manner, I will focus on a particular case study, a line of research that may serve as exemplification of the vicissitudes of contemporary technosciences, namely viral biomaterials. Viral life forms can be genetically modified (their genomes can be rewritten) in such a manner that they may be inserted in human bodies in order to produce substances at specific sites such as hormones (testosterone), neurotransmitters (dopamine), enzymes (insulin) or bone and muscle tissue. Notably, certain target groups such as top athletes, soldiers or patients suffering from degenerative diseases may become the pioneers serving as research subjects for novel applications. The same technologies can be used for various purposes ranging from therapy up to prevention and enhancement. (shrink)

This academic paper on Ethical issues of using umbilical cord blood stem cell therapy of John Stuart Mill perspective aim to investigate the new approaches in the treatment of diseases by using umbilical cord blood stem cells. And also to study ethical issues from the use of umbilical cord blood stem cells in the treatment of diseases considered by Mill’s utilitarianism. 21st century, the medical industry was interested in organ transplantation from stem cells especially stem cells from the umbilical cord (...) to treat chronic and degenerative organ diseases, blood cancer and organ transplantation which successful and widespread throughout the world. Thailand has about 900 new children with Leukemia every year. About 50 percent are leukemia which needs to be treated correctly and urgently. In general Standardized chemotherapy but if the cancer patient has a bad prognosis Or have recurrent cancer Patients need to be treated with bone marrow transplants or stem cells to have a chance to heal. According to Mill’s Utilitarianism, the ethical concepts that determine what is the basic criterion used to determine whether it should or should not concern with the popular benefit that the criterion used is the amount of happiness that results from actions. Treating the disease using stem cells will make the patient recover from the disease, healthier and happier in life. As Mill said "The correctness of an action depends on the tendency that the action will lead to happiness. (shrink)

Imagine a 5-stone weakling whose brain has been loaded with all the knowledge of a champion tennis player. He goes to serve in his first match – Wham! – His arm falls off. The 5-stone weakling just doesn’t have the bone structure or muscular development to serve that hard. There are, clearly, different types of knowledge/ability/skill, only some of which are a matter of what can be transferred simply by passing signals down a wire from one brain (or computer) to (...) another. Sometimes it is the body (the hardware) which knows. (shrink)

Sa bawat aklatan o sabihin pang mga bookstores, hindi talaga nawawala ang sikat na sikat na mga aklat ni Ambeth Ocampo. Isa na rito ang labintatlong tomo ng Looking Back na tumatalakay sa iba’t ibang paksa sa kasaysayan ng Pilipinas. Noong mga panahong nag-aaral pa ang may-akda sa PUP ng kursong Kasaysayan, walong serye pa lamang ng Looking Back ang nailathala at sabihin pang nabasa niya—Looking Back (2010); Dirty Dancing (2010); Death by Garrote (2010); Chulalongkorn’s Elephants: The Philippines in Asian (...) History (2011); Rizal’s Teeth, Bonifacio’s Bones (2012); Prehistoric Philippines (2012); Storm Chasers (2014); at Virgin of Balintawak (2014). Hindi naglaon, tila bagang isang palos ang pagkakalathala ng mga sumunod pang mga akda—Demonyo in Tables: History in Artifacts (2015); Two Lunas, Two Mabinis (2015); Independence X6 (2016); Quezon’s Sukiyaki (2016); at Guns of the Katipunan (2017). Sa mga nabanggit na akda ni Ambeth Ocampo, ang Chulalongkorn’s Elephants: The Philippines in Asian History ang higit na pinagtuunan ng pansin at diin ng rebyuwer. Sa kasalukuyang pagkakataon, ilalatag ng rebyuwer sa papel na ito ang kanyang mga natatanging komendasyon (kalakasan) at kritik (kahinaan) hinggil sa 102-pahinang aklat ni Ocampo. Sisipatin din ang kanyang pagkakadalumat sa ugnayan ng Pilipinas sa mga Asyanikong bansa na siya naman talagang dapat maging tunguhin ng rebyung ito. (shrink)

Darwin’s theory is often illustrated with depictions of different finch beaks or with lined-up skeletons displaying subtle bone-structure changes throughout evolutionary history. In The Deep Histor...

In 1966 Gene Roddenberry, then a relatively unknown TV writer, created what was to become a cultural sensation. From cell phones and tablets, to MRI machines and medical jet injectors, Star Trek has undoubtedly anticipated much of the technology that we take for granted today. Moreover, the disagreements, fights and jokes between Captain Kirk (William Shatner), Dr Leonard ‘Bones’ McCoy (DeForest Kelley) and Mr Spock (Leonard Nimoy) were expertly crafted for dramatic impact. But I’m not writing this to confess (...) to you my obsessive infatuation with the Star Trek universe. Instead I want to discuss how the beliefs and practices of Vulcans like Spock are similar to those of the Stoic school of philosophy. (shrink)

The overarching argument of Currie’s Rock, Bone, and Ruin is that we should be optimistic rather than pessimistic about what the historical sciences can tell us, even about the deep past. To adopt either of these two positions is to take a stance on how the historical sciences tend to perform—on whether they tend to do well, or poorly, when it comes to informing us about the past.

Berkeley’s two most obvious targets in Alciphron are Shaftesbury and Mandeville. However, as numerous commentators have pointed out, there is good reason to think Berkeley additionally targets Anthony Collins in this dialogue. In this paper, I bolster David Berman’s claim that “Collins looms large in the background” of Dialogue VII, and put some meat on the bones of Raymond Martin and John Barresi’s passing suggestion that there is a connection between the Clarke-Collins Correspondence, Alciphron, and the objection that Berkeley (...) raises regarding persons and their persistence conditions therein. Specifically, I argue that we have evidence that Berkeley’s objection to consciousness-based views of personal identity, as found in VII.8, is a response to a challenge that Collins raises to Clarke in “An Answer to Mr. Clarke’s Third Defense of his Letter to Mr. Dodwell.” This is significant not just because this objection is usually—and consistently—taken to be an objection to Locke, but also because Berkeley’s objection works against Collins’s theory of personal identity in a way that it doesn’t against Locke’s. (shrink)

A philosophical exchange broadly inspired by the characters of Berkeley’s Three Dialogues. Hylas is the realist philosopher: the view he stands up for reflects a robust metaphysic that is reassuringly close to common sense, grounded on the twofold persuasion that the world comes structured into entities of various kinds and at various levels and that it is the task of philosophy, if not of science generally, to “bring to light” that structure. Philonous, by contrast, is the anti-realist philosopher (though not (...) necessarily an idealist): his metaphysic is stark, arid, dishearteningly bone-dry, and stems from the conviction that a great deal of the structure that we are used to attribute to the world out there lies, on closer inspection, in our head, in our “organizing practices”, in the complex system of concepts and categories that unrerlie our representation of experience and our need to represent it that way. (shrink)

Potentialists think that the concept of set is importantly modal. Using tensed language as an heuristic, the following bar-bones story introduces the idea of a potential hierarchy of sets: 'Always: for any sets that existed, there is a set whose members are exactly those sets; there are no other sets.' Surprisingly, this story already guarantees well-foundedness and persistence. Moreover, if we assume that time is linear, the ensuing modal set theory is almost definitionally equivalent with non-modal set theories; specifically, (...) with Level Theory, as developed in Part 1. (shrink)

Forty four years after the publication of Harvey Cox‟s The Secular City that celebrated “the progressive secularization of the world as the logical outcome of Biblical religion” (Newsweek)1, we almost feel the bones of religious fundamentalism cracking under the pressure of secularization. At the same time, however, the Hegelian dialectic holds ground as both refuse to be crushed by either; and any compromising stance only begets another rival; to the effect, that it can be said that fundamentalism is never (...) a phenomenon that may be extinguished. (shrink)

Is shadowboxing an effective form of functional exercise? What physiological and morphological changes result from an exercise program based exclusively on shadowboxing for 3 weeks? To date, no empirical research has focused specifically on addressing these questions. Since mixed martial arts (MMA) is the fastest growing sport in the world, and since boxing and kickboxing fitness classes are among the most popular in gyms and fitness clubs worldwide, the lack of research on shadowboxing and martial arts-based fitness programs in the (...) extant literature is a shortcoming that the present article aims to address. This case study involved a previously sedentary individual engaging in an exercise program based exclusively on shadowboxing for 3 weeks. Body composition and heart rate data were collected before, throughout, and upon completion of the 3-week exercise program to determine the effectiveness of shadowboxing for functional fitness purposes. An original shadowboxing program prepared by an Everlast Master Instructor and NASM Certified Personal Trainer (NASM-CPT) and Performance Enhancement Specialist (NASM-PES) was used for this 3-week period. The original shadowboxing program with goals, techniques, and combinations to work on throughout the 3-week program is included in this article. This case study demonstrates that a 3-week exercise program based exclusively on shadowboxing can increase aerobic capacity, muscle mass, bone mass, basal metabolic rate, and daily calorie intake, and decrease resting heart rate, fat mass, body fat percentage, and visceral fat rating in a previously sedentary individual. The results of this research demonstrate that shadowboxing can be a safe and effective form of exercise leading to morphological and physiological improvements including fat loss and increased aerobic capacity. The results of this research also demonstrate that the Tanita BC-1500 is a reliable tool for individuals to evaluate their own fitness progress over time. (shrink)

We do many things with words. We describe, we plan and promise, we invite and command, we hint and intimate. We also use words to wound – to demean, insult, and exclude. The fact that words can have such potent, pernicious effects is puzzling, because they are, after all, just words. As the schoolyard chant goes, “Sticks and stones may break my bones, but words can never hurt me.” Words do hurt though–not only our feelings, but our social status, (...) even our basic dignity as human beings. How can sounds and shapes do all that? Many philosophers have thought of language as a kind of game. Both games and language are complex, abstract structures that we deploy strategically to achieve serious goals, as well as for fun. Thinking through some of these similarities can illuminate how something so intangible can have such powerful effects, and seeing how people wield that power for malicious ends can reveal how to turn the tables and fight back. (shrink)

The tears of Odysseus -- History : music gives voice to the ineffable -- Tears, chills, and broken bones -- The music itself -- Explaining strong emotional responses to music I -- Explaining strong emotional responses to music II -- The sublime, revisited -- Conclusion : values.

In this chapter I seek to provide a theoretical defense of workplace democracy that is independent from and outside the lineage of Marxist and communist theory. Common to the council movements, anarcho- syndicalism and many other forms of libertarian socialism was the idea “that workers’ self- management was central.” Yet the idea of workers’ control has not been subject to the same theoretical development as Marx’s theory, not to mention capitalist economic theory. This chapter aims to contribute at a theoretical (...) level by providing a justification and defense of self- managed workplaces that is independent of the particular historical tradition of the council movements. There is a clear and definitive case for workplace democracy based on first principles that descends to modern times through the Reformation and Enlightenment in the abolitionist, democratic and feminist movements. By the twentieth century, the arguments had been scattered and lost – like the bones of some ancient beast scattered in a desert – partly due to misconceptions, mental blocks and misinterpretations embodied in Marxism, liberalism and economic theory. When one has worked through some of these intellectual roadblocks, then one may be better able to reassemble the case for workplace democracy from well- known first principles developed in the abolitionist, democratic and feminist movements. (shrink)

Sayyid Sadr al-din Mohammad Dashtaki Shirazi is the inventor of the division of composition into unified composition and composition by join. With this division, Dashtaki has expressed a new theory about the composition of the material object from first matter and form, as well as the composition of man from soul and body, and considers these compositions as an alliance and unification, not simply the parts joining to each other. In this paper, we will present Dashtaki’s arguments on the theory (...) of unified composition. We will also examine three objections to this theory and responses to them. Finally, we will examine the background of this theory in Bahmanyar's phrases. Dashtaki believes that when the components in the compound have a real plurality, i.e. each one exists separately from the other, a composition by join is created, such as the composition of a house from numerous clays. But if the components in the compound are united and none of them are separate from the others and exists actually, the resulting composition will be an alliance and union. He believes that in the unified composition, every component is identical to any other component and is identical to the whole. Accordingly, Reza is a unique being, both human and writer. In order to achieve a composition, a plurality is needed and in order to form a single composition, there must be plural components related to each other. An important question is that, principally how is a composition possible, if unified composition comes to existence only when the components are made united with each other and with the whole? In other words, unified composition is not possible, because the first condition of the acquisition of the composition, i.e., the plurality of the constituent components, is not satisfied. Dashtaki strives to express a difference between the components in the union compound. He believes that the conditions of the realization and the survival of the components are different, and that is enough for them to be different. In Dashtaki's point of view, in the unified composition the components are analytical, not being separate and plural, in reality. In other words, the components do not have actual and "in-the-world" plurality, which means that it is our intellect that separates them and looks at them as independent objects. Therefore, unity and identity are in-the-world and plurality and discernibility are analytical and in the mind. Dashtaki's first argument for his theory in general is as follows: the three major material objects (solid, plant and animal) are undoubtedly real compounds. But in these compositions, components exist potentially, and in a unified composition, components do not exist actually. Therefore, these objects are unified compounds. The second argument is that the accuracy of predication implies unity. In the unified composition, the components are identical with the whole, and therefore, the components can be predicated to the composition. In Dashtaki's view, if A is predicated to B, then it could be concluded that they are identical and unified. The first objection to this theory is that the unity is incompatible with causality. From the perspective of the Peripatetics, form is the cause of the matter, and this is incompatible with the union of the two. Dashtaki states that in case of causality, there is no need for cause and effect to be two different and discernible entities, but a single entity may be from one aspect the cause and, from another, the effect. In other words, the foresaid causality is analytical causality. When mind analyses something, and then finds analytical components, it can see between those analytical and intellectual components, causality, and find some of them as the cause of the others. The second objection is the incorrectness of the unity in compounds with components not being similar. only in the compounds having similar parts, one can accept the unity of matter and form. For example, in compounds such as horses, it is not possible to accept the union of matter and form, because in horses, there are components with different natures, such as bones, flesh and nerves. Unity of These parts with each other and with the whole is not plausible. Dashtaki’s respond is that the horse is also a natural unit and has no actual plurality. Components having similar or different natures does not make any difference. According to the theory of unified composition, the horse's components are united with the horse's form and have only analytical plurality. Horse’s components are just analytical components, not actual, independent ones. The third objection is the incompatibility of the actual existence of components with their unity. But Dashtaki maintains that a unique actual personal entity cannot have actual plural components. He states that compounds such as horses exist objectively, but objective and real existing is divided into two kinds: dependent existence, and independent existence as a single real thing. Therefore, the two characteristics of "being a component" and "being independent" are incompatible and do not come together in a real being. Dashtaki has also quoted phrases from Bahmanyar to confirm his point of view. Bahmanyar says that the properties of an animal belong to the whole and compound, not to each component. For example, it is a horse that feels, not its bone or brain, as the eye is also a compound, but seeing is the work of the eye, not the work of any of its components. Therefore, the animal, which is something compound, has characteristics that none of its components have. So the animal is something over and above its components. Bahmanyar thinks the components in the animal are potential. Then he states a general rule: any compound in which unity is real, its components do potentially exist. Therefore, Bahmanyar considers the body parts of the living organism as a potential being and generally believes that the components of any compound that have true unity are potential. The potentiality of the components in a real compound does not that mean that the components are destroyed and a new thing is produced. The components are also available, but they do not have the effects they had separately before the composition comes into existence. In other words, the components have found a unique identity together and therefore have a new effect.. It seems that Bahmanyar has expressed the same idea that Dashtaki is looking for in the theory of unified composition. Therefore, it can be said that before Dashtaki, Bahmanyar has come up with the thought of a unity. Of course, Bahmanyar has not explained much about this, and Dashtaki is the first who has organized and completed this idea as a philosophical theory. (shrink)

In this book I show that science suffers from a damaging but rarely noticed methodological disease, which I call rationalistic neurosis. It is not just the natural sciences which suffer from this condition. The contagion has spread to the social sciences, to philosophy, to the humanities more generally, and to education. The whole academic enterprise, indeed, suffers from versions of the disease. It has extraordinarily damaging long-term consequences. For it has the effect of preventing us from developing traditions and institutions (...) of learning rationally devoted to helping us learn how to make progress towards a wiser, more civilized world. On our fragile earth, overcrowded, fraught with injustice, inequality and conflict, menaced by unprecedented and terrifying technological and industrial means for change and destruction, we urgently need to acquire a little more wisdom and civilization if we are to avoid repeating horrors of the kind suffered by so many during the 20th century (and already suffered by many in the first few years of the 21st century). We can ill afford to have in our hands instruments of learning botched and bungled from the standpoint of helping us learn how to live more wisely. It may seem scarcely credible that something as important as our institutions of learning can suffer from wholesale, structural defects. Why has this not been noticed before? Why have not armies of scientists and scholars appreciated the point and, long ago, put the matter right? The answer will emerge as my argument unfolds. I will show that one of the most damaging features of rationalistic neurosis is that it has built-in methodological and institutional mechanisms which effectively conceal that anything is wrong. But there is also an immediately obvious reason: specialization, and the resulting fragmentation of academia, has resulted in a situation in which hardly anyone takes responsibility for the overall ideals, the overall aims and methods, of academic inquiry. Academics, these days, are specialists, furiously trying to keep abreast of developments in their own specialist fields. They have no time, and no inducement, to lift their eyes from their particular disciplines, and look at the whole endeavour. Science has long been under attack, at least since the Romantic movement. Blake objected to “Single vision & Newton’s sleep” and declared that “Art is the Tree of Life... Science is the Tree of Death”. Keats lamented that science will “clip an Angel’s wings” and “unweave a rainbow”. Whereas the Enlightenment had valued science and reason as tools for the liberation of humanity, Romanticism found science and reason oppressive and destructive, and instead valued art, imagination, inspiration, individual genius, emotional and motivational honesty rather than careful attention to objective fact. Much subsequent opposition to science stems from, or echoes, the Romantic opposition of Blake, Wordsworth, Keats and many others. There is the movement Isaiah Berlin has described as the “Counter-Enlightenment” (Berlin, 1979, ch. 1). There is existentialism, with its denunciation of the tyranny of reason, its passionate affirmation of the value and centrality of irrationality in human life, from Dostoevsky, Kierkegaard and Nietzsche to Heidegger and Sartre (see, for example, Barrett, 1962). There is the attack on Enlightenment ideals concerning science and reason undertaken by the Frankfurt school, by postmodernists and others, from Horkheimer and Adorno to Lyotard, Foucault, Habermas, Derrida, MacIntyre and Rorty (see Gascardi, 1999). The soul-destroying consequences of valuing science and reason too highly is a persistent theme in literature: it is to be found in the works of writers such as D.H. Lawrence, Doris Lessing, Max Frisch, Y. Zamyatin. There is persistent opposition to modern science and technology, and to scientific rationality, often associated with the Romantic wing of the green movement, and given expression in such popular books as Marcuse’s One Dimensional Man, Roszak’s Where the Wasteland Ends, Berman’s The Reenchantment of the World and Appleyard’s Understanding the Present. There is the feminist critique of science and conceptions of science: see, for example, Fox Keller (1984) and Harding (1986). And there are the corrosive implications of the so-called “strong programme” in the sociology of knowledge, and of the work of social constructivist historians of science, which depict scientific knowledge as a belief system alongside many other such conflicting systems, having no more right to claim to constitute knowledge of the truth than these rivals, the scientific view of the world being no more than an elaborate myth, a social construct (see Barnes and Bloor, 1981; Bloor, 1991; Barnes, Bloor and Henry, 1996; Shapin and Schaffer, 1985; Shapin, 1994; Pickering, 1984; Latour, 1987). This latter literature has provoked a counter-attack by scientists, historians and philosophers of science seeking to defend science and traditional conceptions of scientific rationality: see Gross and Levitt (1994), Gross, Levitt and Lewis (1996), and Koertge (1998). This debate between critics and defenders of science came abruptly to public attention with the publication of Alan Sokal’s brilliant hoax article ‘Transgressing the boundaries’ in a special issue of the cultural studies journal Social Text in 1996 entitled Science Wars: see Sokal and Bricmont (1998). What does this book have to contribute, given the above avalanche of criticism of science? The criticisms of science developed in this book are diametrically opposed to the above, in so far as the above criticisms oppose scientific rationality, seek to diminish or restrict its influence, or hold that it is unattainable. My central point is that we suffer, not from too much scientific rationality, but from not enough. What is generally taken to constitute scientific rationality is actually nothing of the kind. It is rationalistic neurosis, a characteristic, influential and damaging kind of irrationality masquerading as rationality. Science is damaged by being trapped within a widely upheld but severely defective philosophy of science; free science from this defective philosophy, provide it with a more intellectually rigorous philosophy, and it will flourish in both intellectual and humanitarian terms. And more generally, as we shall see, academic inquiry as a whole is damaged by being trapped within an intellectually defective philosophy of inquiry; free it from this defective philosophy, from its rationalistic neurosis, and it will flourish in intellectual and human terms. It is not reason that is damaging, but defective pretensions to reason — rationalistic neurosis —masquerading as reason. Thus what I seek to do here is the exact opposite of what all those who oppose science and scientific rationality do. I shall argue that Reason, the authentic article, arrived at by generalizing the progress-achieving methods of science, can have profoundly liberating and enriching consequences for all worthwhile, problematic aspects of life, and thus deserves to enter into every aspect of life. The bare bones of the argument of this book can be stated quite simply like this. Science cannot proceed without making the substantial metaphysical assumption that the universe is physically comprehensible (to some extent at least). But this conflicts with the orthodox view that in science everything is assessed impartially with respect to evidence, nothing being permanently assumed independently of evidence. So the metaphysical assumption of comprehensibility is repressed. Science pretends that no such assumption is made. But this damages science. For the assumption is substantial, influential and highly problematic. It needs to be made explicit within science so that it can be critically scrutinized, so that alternatives can be developed and considered. Pretending the assumption is not being made undermines the intellectual rigour of science, its intellectual value and success. And it does not stop there. For science also makes value assumptions. Quite properly, science is concerned to discover that which is of value. New factual knowledge devoid of all value (whether intellectual or practical) does not contribute to science. But the orthodox view of science holds that values have no place within science. As in the case of metaphysics, here too, science pretends that values have no role to play within the intellectual domain of science. And this damages science. For values are, if anything, even more influential and problematic than metaphysics (in influencing the direction of research). Here too, values need to be made explicit within science so that they can be scrutinized, so that alternatives can be developed and assessed. Pretending that values play no role within the intellectual domain damages science; both the intellectual and the practical aspects of science are adversely affected. Science fails to pursue those avenues of research that lie in the best interests of humanity. And it goes further. Science is pursued in a social, cultural, economic and political context. It is a part of various social, economic and political projects which seek to achieve diverse human objectives. But the idea that science is an integral part of humanitarian or political enterprises with political ends clashes, once again, with the official view of science that the aim of science is to improve factual knowledge. The political objectives of science are repressed. And, once again, this damages science. For, of course, the political objectives of science, like all our political objectives, are profoundly problematic. These need to be made explicit so that they can be scrutinized, so that alternatives can be developed and considered. The pretence that science does not have this political dimension once again undermines the intellectual rigour of science, and its human value. It lays science open to becoming a part of economic, corporate and political enterprises that are not in the best interests of humanity. The upshot of the line of argument just indicated is that we need to bring about a revolution in the aims and methods of science, and of academic inquiry more generally. Natural science needs to change; its relationship with the rest of academic inquiry, with social inquiry and the humanities, needs to change; and most importantly and dramatically, academic inquiry as a whole needs to change. The basic task of the academic enterprise needs to become to help humanity learn how to tackle its problems of living in more cooperatively rational ways than at present. We need to put the intellectual tasks of articulating our problems of living, and proposing and critically assessing possible solutions, possible and actual actions, at the heart of academic inquiry. The basic task needs to be to help humanity learn a bit more wisdom – wisdom being the capacity to realize what is of value in life, for oneself and others, wisdom including knowledge and technological know-how, but much else besides. Natural science, despite its flaws, has massively increased our knowledge and technological know-how. This in turn has led to a massive and sometimes terrifying increase in our power to act. Often this unprecedented power to act is used for human good, as in medicine or agriculture. But it is also used to cause harm, whether unintentionally (initially at least) as when industrialization and modern agriculture lead to global warming, destruction of natural habitats and rapid extinction of species, or intentionally, as when the technology of war is used by governments and terrorists to maim and kill. Before the advent of modern science, when we lacked the means to do too much damage to ourselves and the planet, lack of wisdom did not matter too much. Now, with our unprecedented powers to act, bequeathed to us by science, lack of wisdom has become a menace. This is the crisis behind all the other current global crises: science without wisdom. In these circumstances, to continue to pursue knowledge and technological know-how dissociated from a more fundamental quest for wisdom can only deepen the crisis. As a matter of urgency, we need to free science and academia of their neuroses; we need to bring about a revolution in the academic enterprise so that the basic aim becomes to promote wisdom by intellectual and educational means. At present science and the humanities betray both reason and humanity. The argument of this book, which I have just summarized, begins with a discussion of the philosophical and methodological problems that beset theoretical physics. At once, many of those who are concerned about moral, political and environmental issues that plague our world today, will feel impatient. What have the methodological problems of theoretical physics to do with third world poverty, war and the threat of war, pollution, extinction of species, the menace of conventional, chemical, biological and nuclear armaments? I can only plead with such a reader: patience. The root cause of the sickness of our times does indeed lie, I claim, with a methodological sickness of natural science or, even more specifically, of physical science. What makes the modern world so utterly different from all previous ages is our possession of modern science and technology. This is the instrument that has changed the conditions of human life almost beyond all recognition, and put unprecedented, and sometimes terrifying, powers into our hands. One should not dismiss out of hand the suggestion that a part of our problem may lie with this instrument, this engine, of rapid change. We see, here, too, the way in which intellectual specialization, referred to above, has effectively concealed from view the nature and extent of the problem that confronts us. The argument that I shall develop in what follows begins with physics, with problems concerning the aims and methods of physics. But it then leaps to social science, to philosophy, to the humanities, to education, to psychotherapy, and to politics: in the end there is scarcely an aspect of modern life that is not touched and, potentially, affected by the argument. How many academic experts are prepared to follow, to take seriously, an argument that ranges so recklessly across such a wide range of academic disciplines? How many non-academic non-experts? But just this is what the argument and message of this book requires. I hope that the reader will endure with patience the somewhat esoteric discussion concerning the aims and methods of physics pursued in chapter one. This may not seem to have anything much to do with the urgent problems of our times, but it does. This is in part how the intellectual disaster I seek to expose in this book conceals itself from view: it buries itself in the obscure, recondite field of the philosophy of physics. Those who devote their lives to the philosophy of physics are, by and large, too myopic to see how their specialized field of study has anything to do with the great and dreadful humanitarian problems and disasters of our age; and those who are above all concerned with these humanitarian disasters have no time at all for abstruse issues concerning the aims and methods of physics. And so the connection is never made. As it happens, the methodological neurosis of physics, with which we begin in chapter one, is actually a quite simple matter to grasp. It does not require any real knowledge of physics to understand. Indeed, physicists and philosophers of physics are much more likely to find the argument difficult to follow than are non-experts. We non-scientists can stand back and see the whole wood; scientists, trained to think in terms of the current orthodox conception of science, trapped in the thickets of research, will find this much harder to do. In an attempt to take this peculiar circumstance into account, I have arranged the exposition as follows. In chapter one I give a simple exposition of the case for declaring natural science to suffer from what I call "rationalistic neurosis"; this avoids all technicalities, and goes straight to the heart of the matter. In the appendix I tackle a host of more technical objections that may be made to the elementary argument of chapter one. So, those experts in the fields of the philosophy of physics and philosophy of science who find the argument of chapter one naïve and unconvincing, should consult the appendix before tossing the book away in disgust. I write in the hope that there will be a few who will not dismiss out of hand the suggestion that the question of how we are to go about learning how to live in wiser and more civilized ways might have something to learn from scientific learning, and will take the trouble to pursue the line of argument traced out in this book. I write in the hope that these few will grasp just how desperate our situation is, how urgent the need to change the status quo, and will do everything in their power to alert others to the need to heal the methodological sickness from which our institutions and traditions of learning at present suffer. To begin with, we need a campaigning organization, modelled perhaps on "Friends of the Earth", which might be called something like "Friends of Wisdom". (shrink)

This study aims to describe the cultural strategy of the Buginese people of Pagatan (one of ethnic group in Indonesia) in preserving their local wisdom living in a multicultural society. This research was conducted using qualitative descriptive method through three methods of data collection i.e. in-depth interview, observation and literature involving community leaders and ordinary people as informants. The historical-interpretative method was used to analyze the Data. The findings from this study indicate that the people of Buginese-Pagatan use two strategies (...) to preserve their Buginese identity in a pluralistic society i.e. the strategy of interaction patterns and the use of ethnic symbols. In the strategy of interaction patterns, they implement adaptive and inclusive interaction patterns. This strategy is represented by the mastery and the use of regional languages in addition to the Buginese language, cross-ethnic marriages, and participation in social activities. While in the strategy of using ethnic symbols, they form a distinct identity from the one existing in Sulawesi. This strategy is represented by the use of ethnic symbols such as wearing Bodo clothes, bone cap in the rituals of marriage and moving in new houses, preserving the ancient model of Buginese house for settlement, and forming a new cultural identity called Maccera Tasi. This research has identified local values preserved and held by its people as cultural strategies in building a harmonious society. We believe that the cultural strategies are useful not only to form a united, dignified and civilized local community of Indonesia, but also to serve as a model for other cultures to preserve their local wisdom. (shrink)

In this paper, we apply the perspective of intra-organismal ecology by investigating a family of ecological models suitable to describe a gene therapy to a particular metabolic disorder, the adenosine deaminase deficiency (ADA-SCID). The gene therapy is modeled as the prospective ecological invasion of an organ (here, bone marrow) by genetically modified stem cells, which then operate niche construction in the cellular environment by releasing an enzyme they synthesize. We show that depending on the chosen order (a choice that cannot (...) be made on \textit{a priori} assumptions), different kinds of dynamics are expected, possibly leading to different therapeutic strategies. This drives us to discuss several features of the extension of ecology to intra-organismal ecology. (shrink)

The question which this paper examines is that of the correct scope of the claim that extra-linguistic factors (such as gender and social status) can block the proper workings of natural language. The claim that this is possible has been put forward under the apt label of silencing in the context of Austinian speech act theory. The ‘silencing’ label is apt insofar as when one’s ability to exploit the inherent dynamic of language is ‘blocked’ by one’s gender or social status (...) then one might justly be said to be silenced. The notion that factors independent of any person’s linguistic competence might block her ability to exploit the inherent dynamic of language is of considerable social as well as theoretical significance. I shall defend the claim that factors independent of a person’s linguistic competence can indeed block her ability to do things with words but I will show that the cases that have been previously considered to be cases of illocutionary failure are instances of rhetic or locutionary act failure instead. I shall refine the silencing claim as previously advanced in the debate in at least one fundamental respect. I also show that considering the metaphysics of speech acts clarifies many of the issues previously appearing as thorny bones of contention between those who hold that the only notion of silencing that is coherent is that of physically preventing someone from speaking or writing and those who hold the opposite sort of claim sketched above. (shrink)

In fairy tales, villains usually come to a bad end, snared in a trap of their own making, or visited with a disaster nicely suited to their particular villainy. Read a story of this kind to children and you will be struck by the profound satisfaction with which this predictable of events is greeted. Yet, if children cheer when the villain is done in, they are just as satisfied when the hero manages to get the villain by the throat but (...) takes pity and spares him. These tales of retribution and mercy, even reduced to their barest bones, seem to have an intrinsic significance; they strike some inner chord, resonate with something fundamental in our inarticulate understanding of the world, reveal something about the basic make-up of the world. This is not to suggest that they are 'realistic' in the ordinary sense. They do not tell us what 'really happens' in the world of experience, where the villain all too often flourishes and the innocent are trampled underfoot. Rather, fairy tales reveal to us the injustice of the human world by testifying to the true nature of justice. If we did not know that villains ought to get their comeuppance, we would have no reason to think it wrong that they often escape to enjoy their spoils. Tales of retribution and mercy speak of the reality of a world beyond the world of everyday experience; so doing, they show the world of experience in its true light. In the best sense of the word, they are 'myths': stories that, even when told in their simplest form, carry a profound inner significance. (shrink)

-/- Extending Human Lifespan: Scientific and Technological Possibilities -/- The quest for extending human lifespan has fascinated humanity for centuries. Advances in genetics, medicine, artificial intelligence, and bioengineering are bringing us closer to significantly prolonging life, potentially even achieving biological immortality. This essay explores various scientific and technological approaches to extending human life, from genetic modifications to mind uploading. -/- 1. Genetic Engineering & Cellular Reprogramming -/- One of the most promising fields in lifespan extension is genetic engineering. Our DNA (...) holds the key to aging, and modifying it could slow or even reverse the aging process. -/- Gene Therapy: Scientists are exploring ways to edit genes associated with aging and longevity, such as the FOXO3 and SIRT genes. CRISPR gene-editing technology allows precise modifications to enhance DNA repair mechanisms and eliminate age-related mutations. -/- Telomere Extension: Telomeres, the protective caps at the ends of chromosomes, shorten with age. Techniques like telomerase activation could extend telomeres, effectively delaying cellular aging. -/- Epigenetic Reprogramming: Aging is influenced by chemical changes in DNA called epigenetic markers. Scientists like Dr. David Sinclair are working on methods to reset these markers, restoring youthful function in cells. -/- 2. Anti-Aging Drugs & Therapies -/- Medical research is identifying compounds that slow aging and enhance longevity. Some of the most promising drugs and therapies include: -/- Senolytics: These drugs target and remove senescent cells, which accumulate with age and contribute to inflammation and tissue damage. Removing them has been shown to extend lifespan in mice. -/- Metformin & Rapamycin: Metformin, a common diabetes drug, has shown promise in reducing cellular stress and extending lifespan. Rapamycin, originally used for transplant patients, has been found to mimic calorie restriction, enhancing longevity in animals. -/- NAD+ Boosters: Nicotinamide adenine dinucleotide (NAD+) is a molecule essential for cellular energy production. As we age, NAD+ levels decline, leading to cellular dysfunction. Boosters like NMN and NR are being tested to restore energy metabolism and promote longer lifespans. -/- 3. Regenerative Medicine & Organ Replacement -/- Aging is often associated with organ failure, but regenerative medicine could help replace worn-out body parts. -/- Stem Cell Therapy: Stem cells have the potential to repair or replace damaged tissues, offering a biological rejuvenation strategy. Scientists are investigating methods to grow new skin, bones, and even organs using stem cells. -/- 3D Bioprinting & Artificial Organs: Advances in 3D printing allow researchers to create lab-grown organs, such as artificial hearts, kidneys, and livers, which could replace failing ones without the need for donors. -/- Cloning & Tissue Engineering: Personalized tissue regeneration using a patient’s own cells could eliminate transplant rejection risks. Scientists are also exploring ways to clone healthy organs for transplantation. -/- 4. Enhancing Brain & Cognitive Function -/- Longevity is meaningless without maintaining cognitive function. Neurodegenerative diseases like Alzheimer’s pose a significant threat to longevity, but new technologies are emerging to counteract cognitive decline. -/- Neural Implants & Brain-Computer Interfaces (BCIs): Companies like Neuralink are developing brain implants that could enhance memory, prevent neurological diseases, and even allow direct communication with AI. -/- Cryopreservation: Some futurists believe in cryonics, the process of freezing the brain (or entire body) after death in the hope of future revival using advanced medical technology. -/- AI Integration: Artificial intelligence could assist in decision-making, memory enhancement, and mental health support, preserving cognitive abilities well into old age. -/- 5. Lifestyle & Environmental Optimization -/- While high-tech solutions are promising, natural lifestyle changes have been shown to promote longevity. -/- Diet & Caloric Restriction: Studies indicate that intermittent fasting and calorie restriction can extend lifespan by reducing oxidative stress and inflammation. -/- Exercise & Hormesis: Regular physical activity helps maintain muscle mass, cardiovascular health, and brain function. Hormesis—exposing the body to mild stress, like cold showers or sauna therapy—has also been linked to longevity. -/- Microbiome Optimization: A healthy gut microbiome influences the immune system, metabolism, and overall health. Prebiotics, probiotics, and personalized microbiome therapies could extend lifespan by reducing chronic diseases. -/- 6. Nanotechnology & Molecular Repair -/- Future breakthroughs in nanotechnology may allow precise control over aging processes at the molecular level. -/- Nanomedicine: Tiny robots (nanobots) could patrol the bloodstream, repairing cellular damage, removing toxins, and targeting diseases at the microscopic level. -/- Artificial Blood Cells: Scientists are developing synthetic blood that can enhance oxygen delivery and immune function, potentially extending life. -/- Targeted Drug Delivery: Advanced drug delivery systems using nanoparticles can deliver medication exactly where needed, reducing side effects and increasing effectiveness. -/- 7. Mind Uploading & Post-Biological Life -/- The most radical vision for immortality involves leaving behind the biological body altogether. -/- Whole Brain Emulation: Researchers are exploring the idea of scanning and copying a human brain into a digital system. If successful, this would allow a person’s consciousness to continue in a virtual or robotic form. -/- Consciousness Transfer: Some futurists speculate that advanced AI or quantum computing might enable transferring human consciousness into an artificial body, bypassing biological aging altogether. -/- Conclusion: The Future of Human Longevity -/- While full immortality remains theoretical, science is making rapid progress in extending human life and improving quality of life. A combination of genetic engineering, regenerative medicine, AI integration, nanotechnology, and lifestyle optimization may push human lifespan beyond 120 years, potentially even eliminating aging as a cause of death. -/- However, ethical, social, and economic challenges must also be addressed. Who will have access to these life-extending technologies? How will society handle overpopulation and resource distribution? These are critical questions as humanity moves toward a longer and healthier future. -/- . (shrink)

This small book continues the theoretical study on the structure of the universe. It examines the category of “time” in the light of a new cosmological model proposed by the author in his book “The Origin of Mankind”. It is generally accepted that after researches of A. Einstein, А. Minkovsky and others space and time are considered in their interrelation, as the continuum. Nevertheless, the category of “time” is still a bone of contention and a cause of a great deal (...) of misunderstanding in contemporary science. In philosophy, mathematics, physics it has different meanings. In this book the author dares to give more precise definition of the category of “time” from the point of view of the contemporary level of knowledge. (shrink)

FISIOLOGIA DO PARTO E DA LACTAÇÃO ANIMAL -/- ANIMAL REPRODUCTION: PHISIOLOGY OF PARTURITION AND ANIMAL LACTATION -/- Emanuel Isaque Cordeiro da Silva Departamento de Zootecnia da UFRPE WhatsApp: (82)98143-8399 -/- 1. INTRODUÇÃO O sucesso biológico do processo de reprodução culmina com a sobrevivência das crias. Durante a gestação, o feto desenvolve-se no útero materno protegido das influências externas, e obtendo os nutrientes e o oxigênio através da mãe. O parto é o processo biológico que marca o fim da gestação e (...) o início da vida extrauterina do animal. Para garantir a sobrevivência do recém-nascido o parto deve ser um processo controlado para que se inicie unicamente quando o feto tiver alcançado desenvolvimento suficiente que lhe permita enfrentar a vida extrauterina. Após o nascimento, a secreção de leite pela glândula mamária proporciona ao neonato tanto os nutrientes necessários para seu desenvolvimento como as defesas (imunoglobulinas) que lhe protegerão contra as possíveis infecções durante as primeiras fases de sua vida. Parto e lactação constituem a última etapa de um ciclo reprodutivo completo nas fêmeas dos animais domésticos, estando ambos os processos regulados e sincronizados por complexas mudanças hormonais na mãe. Estas mudanças são, em última análise, provocadas e governadas pelo próprio feto ou recém-nascido, o qual acomoda as respostas maternas às suas necessidades garantindo a sua sobrevivência. 2. O PARTO O parto é definido como o processo fisiológico pelo qual ocorre a expulsão de um ou mais fetos maduros, bem como das membranas fetais existentes no útero materno. Este processo é desencadeado por uma interação complexa entre as hormonas maternas (fatores maternos) e fetais (fatores fetais). Para que se realize a expulsão do feto é necessário que o útero deixe de ser um órgão quiescente, essencial para a manutenção da gestação, para ser um órgão contrátil. Ao mesmo tempo, o cérvix ou colo uterino, que durante a gestação permanece firmemente fechado para impedir a expulsão prematura do feto e evitar a entrada de agentes infecciosos, relaxa e dilata para facilitar a passagem do feto na hora do parto. Esta modificação na atividade do útero e do colo uterino, ocorrem como consequência das mudanças hormonais que o organismo materno experimenta à medida que a data do parto se aproxima. 2.1 Fatores maternos A gestação dos animais domésticos ocorre com elevada concentração de progesterona que, dependendo da espécie animal, é secretada seja pelo corpo lúteo do ovário (vaca, porca e cabra) ou pela placenta (ovelha e égua). A progesterona desempenha um papel fundamental durante a gestação, inibindo as contrações da musculatura lisa do útero (miométrio), permitindo assim a acomodação do feto durante o seu crescimento. Os estrogênios, estimulantes da atividade contrátil do miométrio, mantêm-se a baixas concentrações durante a maior parte da gestação. À medida que se aproxima o momento do parto, os níveis destes hormônios esteroides modificam-se, produzindo-se a diminuição nos níveis circulantes da progesterona ao mesmo tempo que se incrementam os valores sanguíneos dos estrogênios (figura 1). A redução dos níveis de progesterona suprime a sua ação inibitória sobre a atividade contrátil do miométrio, permitindo que se manifestem os efeitos estimulantes dos estrogênios sobre este órgão. A concentração de estrogênios começa a aumentar geralmente no final da gestação, atingindo os seus valores máximos no momento do parto (figura 1). O aumento da concentração de estrogênios favorece a atividade contrátil espontânea do útero ao: a) estimular a síntese de proteínas contráteis; b) aumentar, sob medida, a sensibilidade do miométrio uterino à ação estimulante das prostaglandinas; c) induzir a formação de receptores de oxitocina no útero. -/- Figura 1. Níveis de progesterona e estrógenos durante a gestação e parto das espécies ovina, caprina, suína e bovina. Fonte: HAFEZ, 2013. Os estrogênios estimulam a síntese e secreção de prostaglandina (PGF2a), que constitui o elemento essencial para o início do parto devido aos efeitos que esta substância provoca. Assim, nas fêmeas, cujos níveis de progesterona gestacional dependem da presença do corpo lúteo, a secreção de PGF, origina a regressão deste (luteólise), com a consequente diminuição da progesterona a níveis basais. Além disso, a PGF2a origina contrações de crescente intensidade no útero sensibilizado pela ação dos estrogênios. Esta ação contrátil da PGF2a deve-se a um aumento da concentração de cálcio intracelular das fibras musculares uterinas. A PGF2a também está envolvida no relaxamento do colo do útero, inibindo a formação de colágeno cervical ao mesmo tempo que estimula a síntese de enzimas (colagenase) que degradam a matriz de colágeno formado no início da gestação. A dilatação do colo do útero está também associada à pressão que o feto exerce sobre o mesmo e, no caso da porca, a relaxina pode também estar envolvida. Esta hormona é também de grande importância para a preparação do parto em todas as espécies animais, uma vez que é responsável pelo relaxamento dos ligamentos e músculos que rodeiam o canal pélvico para favorecer a separação da sínfise púbica durante a expulsão do feto. Nos grandes animais (vaca, égua) as mudanças que ocorrem nos tecidos e ligamentos pélvicos são muito evidentes e constituem um sintoma de parto iminente. O início do parto, ou primeira fase do parto, caracteriza-se pelo aumento das contrações uterinas provocadas pela PGF2a coincidindo com a dilatação do colo uterino para permitir a passagem do feto para o canal do parto, momento em que começa a segunda fase do parto. A distensão vaginal que produz-se para a passagem do feto pelo canal do parto origina um estímulo nervoso que viaja através da medula espinal para o hipotálamo, onde se encontram os neurônios responsáveis pela síntese de oxitocina. As terminações nervosas destes neurónios são projetadas para o lobo posterior da hipófise (neurohipófise), onde a oxitocina é secretada para ser, posteriormente , transportada pela circulação sanguínea. Este reflexo neuroendócrino chamado reflexo de Ferguson determina a secreção súbita de oxitocina, provocando o aumento tanto na intensidade como na frequência das contrações uterinas necessárias para a expulsão final do feto. O papel da oxitocina é ativar a conclusão do processo de expulsão, uma vez que esta hormona não está envolvida no início do parto. A alteração mais significativa entre a gestação e o parto é a alteração na atividade contrátil do miométrio uterino. Esta mudança é devido às alterações hormonais que ocorrem na mãe quando a gestação chegou a fim. No entanto, para que estes mecanismos maternos sejam acionados, é necessário que o feto indique de alguma forma à mãe o seu estado de desenvolvimento, de modo que o nascimento realize-se quando o feto estiver preparado para enfrentar a vida extrauterina. 2.2 Fatores fetais A destruição experimental da hipófise e/ou das glândulas adrenais do feto origina o prolongamento da gestação nos animais domésticos. Pelo contrário, a administração exógena de cortisol (corticosteroides adrenais), ou do seu precursor hipofisário (ACTH), à circulação fetal provoca, em poucas horas, o início do parto. Estes fatos evidenciam a importância do eixo hipófise-adrenal do feto para desencadear o início do parto (figura 2). Figura 2. Mecanismos fetais que controlam o parto em ovelhas. Fonte: LIGGINS et al, 1972. No final da gestação, o feto maduro apresenta um aumento da concentração de corticosteroides plasmáticos devido ao efeito estimulante da hormona adrenocorticotróide (ACVH) secretada pela hipófise fetal sobre as glândulas adrenais do feto. Os corticosteroides fetais por sua vez estimulam as enzimas placentárias para transformar a progesterona em estrogênio. O resultado final é a diminuição dos níveis de progesterona ao mesmo tempo que se eleva a concentração de estrogênios que, por sua vez, estimulam a libertação de PGF2a responsável pelas contrações uterinas. Este raciocínio explica algumas doenças caracterizadas por gestação prolongada em ovelhas, como ocorre na África do Sul, onde estes animais são obrigados, durante as épocas de seca, a ingerir as folhas de um arbusto chamado Salsola tuberculate. O prolongamento da gestação ocorre quando estas folhas são ingeridas durante o último terço da gestação cujos efeitos estão relacionados com a supressão do eixo hipotálamo-hipófise, com o qual as adrenais não recebem o estímulo necessário (ACTH) para a síntese e liberação de corticoides. O efeito contrário é observado nas cabras da raça Angorá, nas quais se produzem, com relativa frequência, partos prematuros que podem estar relacionados com um desenvolvimento precoce das glândulas adrenais. Isto significa que, nos animais domésticos, o feto determina a data do parto. O sinal hormonal que indica à mãe o grau de maturidade do feto é o desenvolvimento do eixo hipotálamo-hipófise-adrenal que origina o aumento na secreção de corticoides fetais que são os responsáveis por desencadear as alterações hormonais no organismo materno necessárias para iniciar o parto. A figura 2 mostra como a remoção da hipófise e as adrenais do feto prolongam a gestação, enquanto a administração exógena de ACTH ou corticoides (cortisol) ao feto originam um parto prematuro. O momento em que ocorre o aumento da concentração plasmática de corticoides no feto varia de acordo com a espécie: de 25 a 30 dias antes do parto na vaca, de 7 a 10 dias na porca e de 2 a 3 dias na ovelha. 2.3 Desenvolvimento e fases do parto O parto inicia-se com o início das contrações peristálticas e regulares do miométrio uterino ao mesmo tempo que o colo do útero se dilata progressivamente. Nas fêmeas que gestam um único feto (monotecas), as contrações começam na extremidade anterior do córneo uterino, enquanto que nas espécies que gestam vários fetos (politocas) as contrações começam pela extremidade cervical para começar a expulsar o feto que se encontra mais próximo do cérvix. Durante o parto são reconhecidas três fases: 1. Fase preparatória - Na qual as contrações uterinas estimulam a rotação do feto (fêmeas monotecas) para adotar a posição dorsal (extremidades anteriores e cabeça forçadas contra o cérvix) que lhe permite oferecer a menor resistência para sua expulsão. A PGF2a provoca as contrações miometriais e a dilatação do cérvix, deslocando o feto contra e através desta estrutura. 2. Fase de expulsão - A passagem do feto através do colo uterino e da vagina causam a completa dilatação destas estruturas, originando a secreção de oxitocina (reflexo de Ferguson), que provoca contrações de maior frequência e intensidade. Por sua vez, estas contrações uterinas são reforçadas pela pressão e contração dos músculos abdominais, chegando estes últimos a ser a força principal (forças de expulsão) envolvida no processo de expulsão do feto. O cordão umbilical rompe-se bem ao levantar-se a mãe ou pelos movimentos do recém-nascido. 3. Fase de expulsão da placenta - Após o parto, as contrações rítmicas do útero continuam a facilitar a expulsão da(s) placenta(s). O tempo necessário para este processo varia de acordo com a espécie animal. Este processo é rápido na égua, já que a separação do corion (membrana fetal) de sua inserção uterina ocorre durante a expulsão do feto, com o qual o parto deve ser concluído rapidamente ou, caso contrário, o potro se asfixiaria. Nos ruminantes, a expulsão da placenta cotiledonaria é um processo mais lento que exige a separação dos cotilédones (membrana fetal) das carúnculas do útero. Por conseguinte, a troca de nutrientes e oxigênio entre a mãe e o feto continua até que este tenha sido totalmente expelido, devido ao cordão umbilical destes animais ser bastante longo. Nas fêmeas politocas, como a porca, geralmente as placentas de vários leitões são expulsadas no final, quando os leitões já foram expelidos, se bem que o último leitão poderá ser expelido durante a expulsão da massa placentária. 3. LACTAÇÃO A lactação constitui o processo que define os mamíferos como classe biológica. O desenvolvimento pós-natal dos mamíferos vai depender, em grande medida, dos nutrientes e defesas fornecidos pela mãe através da secreção de leite (imunoglobulinas). Assim, uma vez concluído o desenvolvimento gestacional do feto, a glândula mamária irá substituir, de certa forma, a função nutritiva e protetora da placenta durante a gestação. 3.1 Anatomia funcional da glândula mamária A estrutura funcional da glândula mamária é muito semelhante em todos os mamíferos, embora o tamanho, forma e número de glândulas varia dependendo da espécie animal. As glândulas mamárias desenvolvem-se como estruturas pares cujo número varia de um par (égua, cabra e ovelha), dois pares (vaca) até sete ou nove (porca). A localização das glândulas também difere sendo inguinal em vaca, égua, cabra e ovelha, enquanto que na porca, cadela e gata se estendem por todo o comprimento do tórax e abdômen. Nos animais domésticos em geral as glândulas mamárias recebem o nome de úberes. Tomando como modelo a vaca, a glândula mamária se organiza em duas estruturas: o estroma, formado por tecido conjuntivo procedente dos ligamentos suspensório medial, localizado entre os dois pares de glândulas, dando suporte à segunda estrutura que é o tecido secretor. Este é formado por acúmulos de células secretoras formando estruturas ocas chamadas alvéolos, que são as unidades fundamentais secretoras de leite. Os alvéolos estão circulados internamente por células epiteliais (secretoras) e rodeados externamente por células mioepiteliais contráteis, cuja contração origina a ejeção do leite (figura 3). O agrupamento de vários alvéolos adjacentes formam um lobo secretor. Figura 3. Diagrama de um agregado de alvéolos na glândula mamária de uma cabra. Fonte: COWIE et al, 1980. Os lobos expelem a secreção através de ductos que, por sua vez, drenam os ductos galactóforas (ductos lácteos) de maior diâmetro, para desembocar em áreas especializadas em armazenar o leite chamadas cisternas (vaca, cabra). Finalmente, a cisterna abre-se para o exterior através do canal papilar da teta. A presença do músculo liso na teta permite-lhe agir como esfíncter para impedir que o leite seja expelido passivamente do interior da glândula. O mamilo/teta é provido de numerosos receptores sensitivos cuja excitação durante a ordenha ou amamentação vai desencadear estímulos nervosos de grande importância para a manutenção da lactação. 3.2 Desenvolvimento da glândula mamária (mamogênese) A glândula mamária difere das demais glândulas do organismo no escasso desenvolvimento que apresenta no nascimento da fêmea, o qual não se inicia até que esta não atinja a puberdade. O início da atividade cíclica do ovário (puberdade) dá origem à síntese de estrogênios (fase folicular do ciclo estral) e progesterona (fase lútea). Os estrogênios originam o alongamento e ramificação dos ductos e a formação de pequenas massas esféricas de células (os futuros alvéolos). Embora este desenvolvimento seja dependente do estrogênio, é também necessária a ação sinérgica da prolactina, hormona do crescimento (GH) e corticoides adrenais, como demonstrado pelos estudos realizados em ratos aos quais foi removida a hipófise, glândulas suprarrenais e ovários (figura 4). A função da progesterona no desenvolvimento da glândula mamária é estimular o crescimento do lobo-alveolar, mas como no caso anterior também requer a ação conjunta dos hormônios acima mencionados. Figura 4. Hormonas relacionadas com o crescimento da glândula mamária e início da secreção de leite na rata hipofisectomizada-adrenoectomizada-ovariectomizada. Fonte: COWIE, 1980. O desenvolvimento da glândula, durante cada ciclo estral, vai depender da duração da fase folicular (níveis elevados de estrogênio), já que nas restantes fases do ciclo, quando os níveis de estrogênio são baixos, os ductos sofrem uma ligeira regressão. Nas espécies com ciclos curtos (rata), em que a fase folicular do ciclo é predominante, enquanto a fase lútea é quase inexistente, verifica-se um grande desenvolvimento dos ductos; enquanto que aquelas que apresentam um corpo lúteo funcional de longa duração (cadela e primatas), além do crescimento dos ductos, mostram um grande desenvolvimento lóbulo-alveolar semelhante ao que ocorre na gestação. É durante a gestação que o sistema alveolar sofre uma hipertrofia considerável, resultando em lobos proeminentes e no desenvolvimento da luz interna dos alvéolos, fato que é evidente na maioria dos animais domésticos por volta da metade do período gestacional. Em algumas espécies, as células que circundam interiormente os alvéolos contêm produtos secretores, indicando que a glândula mamária já está preparada para a fase da lactação. O desenvolvimento glandular durante a gestação deve-se ao efeito conjunto da progesterona e dos estrogênios com as hormonas hipofisárias acima mencionadas: prolactina, hormona do crescimento (GH) e adrenocorticotropina (ACTH). A proporção entre estrogênios e progesterona varia de acordo com a espécie, mas geralmente é necessária uma maior concentração de progesterona (proveniente do corpo lúteo ou da placenta). Quanto às hormonas hipofisárias, a prolactina desempenha um papel fundamental na diferenciação da glândula mamária (mesmo a baixas concentrações) ao estimular o desenvolvimento do epitélio secretor dos alvéolos. A GH favorece o crescimento dos ductos e a ACTH estimula a secreção de corticoides nas adrenais que, por sua vez, favorecem de forma generalizada o crescimento das glândulas. 3.3 Secreção da glândula mamária (lactogênese) A lactogênese, ou o processo pelo qual se produz a síntese e secreção do leite pela glândula mamária, começa no final da gestação coincidindo com o desencadeamento do parto. O primeiro leite formado imediatamente antes ou depois do parto é denominado colostro. No entanto, a lactação não pode desenvolver- se completamente até que se inicie o processo de parto. Isto deve-se ao fato de que o processo de lactação resulta de uma interação complexa de hormonas que preparam a glândula mamária para a secreção do leite. Os requisitos hormonais mínimos para o início da lactogênese são: aumento da secreção de estrogênios, prolactina e corticoides, juntamente com a diminuição da concentração de progesterona, perfis hormonais que estão intimamente relacionados com o desencadeamento do parto. Isto deve-se ao fato de que a progesterona inibe a atividade lactogênica da prolactina bloqueando a formação dos seus receptores na glândula mamária durante a gestação impedindo, assim, a prolactina de sintetizar os componentes fundamentais do leite. Pelo contrário, o aumento da concentração de estrogênios no final da gestação (figura 1, na seção do parto) estimula a síntese, o armazenamento e a secreção hipofisária de prolactina. Assim, apesar da glândula mamária estar preparada para iniciar a secreção de leite, muito antes da data prevista para o parto, a elevada concentração de progesterona (existente durante esse período de gestação) impede a fase láctea (saída do leite pelas tetas) de ocorrer antes da expulsão do feto. Desta forma, o feto poderá beneficiar das vantagens que o fornecimento do colostro materno irá trazer para a sua sobrevivência (imunização, nutrição e favorecimento da exoneração do mecônio). O aumento da concentração de estrogênios nos dias que antecederem o parto resulta num rápido aumento das concentrações plasmáticas de prolactina e corticoides. A prolactina é a hormona lactogênica mais importante na síntese dos componentes do leite. No entanto, para que esta hormona possa exercer a sua função, é necessária a participação dos corticoides, já que os mesmos são os responsáveis pelo desenvolvimento das organelas citoplasmáticas (retículo endoplasmático rugoso e aparelho de Golgi) onde se realiza a síntese do leite. No desenvolvimento da lactogênese, para além da prolactina e dos corticoides, participam também outras hormonas como a insulina, a tiroxina e o hormônio do crescimento. A insulina estimula a proliferação de novas células epiteliais na glândula mamária, enquanto a tiroxina, embora não seja essencial para a lactação, pode influenciar no volume de leite produzido pela fêmea (alta produção leiteira). Por último, a hormona do crescimento favorece, em geral, a lactação, existindo atualmente um interesse considerável no uso desta hormona para promover a produção adicional de leite em vacas através da sua administração exógena (trabalho e projeto desenvolvido pela professora titular e médica-veterinária do IFPB Campus Sousa Marianne Christina Velaqua). 3.3.1 Síntese e secreção dos componentes do leite Os principais constituintes do leite são: proteínas (caseína, alfa-lactalbumina, albumina sérica e imunoglobulinas), açúcares (lactose), gorduras (principalmente sob a forma de triglicerídeos), vitaminas, minerais e citrato (no caso dos ruminantes). As proteínas (caseína e alfa-lactalbumina) são sintetizadas no retículo endoplasmático rugoso e posteriormente embaladas em vesículas secretoras do aparelho de Golgi para serem liberadas da célula para a luz alveolar mediante um processo de exocitose. A lactose é o principal açúcar do leite que, além disso, atua regulando a pressão osmótica do mesmo de modo que o volume de leite que a glândula mamária segrega está diretamente relacionado com a quantidade de lactose presente. A síntese da lactose ocorre no aparelho de Golgi pela condensação de glicose e galactose; esta reação é catalisada por uma enzima (lactose sintetase) presente na membrana do aparelho de Golgi que, por sua vez, é ativada pela proteína alfa-lactalbumina. Esta proteína só aparece na glândula mamária e é essencial para a síntese da lactose, o que demonstra que este açúcar é exclusivamente formado no leite. A lactose é também embalada junto com o cálcio, o fosfato e as proteínas nas vesículas secretoras para ser expulsada ao lúmen alveolar por exocitose. As imunoglobulinas (anticorpos IgA) são formadas pelas células plasmáticas, derivadas dos linfócitos B do sangue, como consequência da exposição da mãe a diferentes microrganismos. Estes anticorpos passam para a glândula mamária por migração dessas células a partir dos tecidos adjacentes. Os triglicerídeos são sintetizados no citoplasma e no retículo endoplasmático liso a partir de ácidos graxos provenientes da circulação sanguínea; em seguida, unem-se formando glóbulos de gordura que se dirigem até o vértice da membrana plasmática para serem finalmente expelidos para a luz do alvéolo, rodeados pela membrana, formando assim uma dispersão de glóbulos de gordura (figura 5). Figura 5. Estrutura de três células alveolares durante a síntese do leite. Fonte: COWIE, 1980. Do ponto de vista quantitativo, a caseína e os triglicerídeos constituem as proteínas e as fontes de energia, respectivamente, mais importantes do leite. Por último, o citrato é um intermediário do metabolismo da glicose que ocorre em grande concentração no leite dos ruminantes. Este composto é também englobado no interior das vesículas secretoras, junto com os outros compostos, para sua expulsão à luz alveolar. A composição do leite varia dependendo da espécie animal, e difere também até entre a mesma espécie. Estas variações estão relacionadas com a raça, idade, estágio de lactação e estado nutricional do animal. O teor de gordura no leite de ovelhas, porcas, cadelas e gatas varia entre 7 e 10%. No gado leiteiro estes valores variam de 3,5 a 5,5%, dependendo da raça. Em relação às cabras, os valores de gordura são muito semelhantes aos das vacas, enquanto o leite das éguas é o que tem menor teor de gordura (tabela 1). Espécie Gordura Proteína Lactosa Cinzas/Cálcio Gata 7,1 10,1 4,2 0,5 Vaca holandesa 3,5 3,1 4,9 0,7 Cadela 9,5 9,3 3,1 1,2 Cabra 3,5 3,1 4,6 0,8 Égua 1,6 2,4 6,1 0,5 Tabela 1. Composição do leite em várias espécies (%). Fonte: JACOBISON, 1984. 3.4 Manutenção da lactação (galactopoiese) A capacidade da glândula mamária de secretar um grande volume de leite começa em/ou imediatamente antes do parto, para aumentar no período pós-parto durante um tempo variável e, posteriormente, diminuir de forma gradual. Em geral, existe um paralelismo entre a atividade secretora da glândula e a procura de leite por parte do lactente. Isto deve-se ao fato de sucção pelo lactente, ou a extração por ordenha, que constituem o fator fundamental para a manutenção da lactação. A sucção estimula a lactação de duas formas: a) reduzindo os efeitos inibitórios da pressão intramamária produzida pela acumulação de leite, e b) estimulando intensamente a secreção de hormonas necessárias para manter a síntese e secreção de leite nos alvéolos. As hormonas que desempenham um papel fundamental na manutenção da lactação são: I) a prolactina, que é responsável pela estimulação da síntese e secreção de leite nas células epiteliais nos alvéolos, e 2) a oxitocina, que provoca a contração das células musculares que circundam externamente os alvéolos e os ductos (células mioepiteliais). A libertação de ambos os hormônios ocorre como resultado de um reflexo neuroendócrino originado pela estimulação do mamilo. 3.4.1 Secreção reflexa de prolactina A secreção de prolactina é regulada por dois fatores hipotalâmicos: a dopamina, que inibe a secreção de prolactina e um fator cuja identidade não está bem definida, conhecido como fator liberador de prolactina (PRF)que estimula a liberação deste hormônio. O estímulo sensorial originado como sequência da estimulação do mamilo, pela sucção do lactente, é transportado através da medula espinhal para o hipotálamo, onde atua na inibição da dopamina ou estimulando a secreção do PRF para desencadear a secreção de prolactina da adenohipófise para a circulação sanguínea (figura 6). Figura 6. Reflexos neuroendócrinos secretores de prolactina e oxitocina. Fonte: HAFEZ, 2000. A prolactina estimula a secreção dos componentes do leite para a luz dos alvéolos, afim de repor o volume de leite extraído durante a última ordenha ou sucção. Ao mesmo tempo, a prolactina induz a síntese das proteínas, incluindo a alfa-lactalbumina para estimular novamente a síntese da lactosa, bem como as enzimas necessárias para a produção dos triglicerídeos. Desta forma, a secreção de prolactina originada pelo lactente durante o aleitamento proporciona um mecanismo simples para combinar o volume de produção de leite com as necessidades do lactente. A quantidade de prolactina liberada durante cada período de sucção depende do número de crias, da duração do estímulo e dos intervalos de tempo decorridos entre os períodos de sucção (ou ordenha). No caso das vacas leiteiras, as ordenhas são geralmente realizadas de doze em doze horas, intervalo de tempo suficiente para manter a lactogênese. Os valores plasmáticos de prolactina aumentam imediatamente após o início da ordenha, mas os valores mais elevados são obtidos cerca de meia hora após o início do estímulo (ordenha ou sucção). A secreção de prolactina e a produção de leite são influenciadas de alguma forma pelo fotoperíodo, uma vez que, em alguns animais se comprovou como o aumento do número de horas de exposição à luz dá origem a um aumento da concentração de prolactina circulante, bem como uma maior produção de leite (entre 6 e 10%) (trabalho e projeto elaborado pelos estudantes do curso técnico em agropecuária e da graduação em Medicina Veterinária do IFPB Campus Sousa sob a coordenação e orientação da profa. Me. Esp. Marianne C. Velaqua). 3.4.2 Reflexo da ejeção do leite A sucção do mamilo pelo lactente estimula os receptores sensoriais presentes nesta estrutura, originando a geração de impulsos nervosos que são transmitidos pelas vias nervosas ascendentes da medula espinhal para os corpos celulares produtores de oxitocina no hipotálamo. O estímulo desencadeia a síntese e liberação de um bolo de oxitocina através das terminações nervosas dos núcleos hipotalâmicos para a neurohipófise, da qual é transmitida, através do sangue, para a glândula mamária, provocando a contração das células mioepiteliais que rodeiam os alvéolos (figura 6). Além da estimulação direta do mamilo provocada pela sucção, qualquer estímulo relacionado à ordenha é capaz de gerar o reflexo da ejeção, por exemplo: os estímulos sensoriais auditivos (ruído dos cubos na hora da ordenha), visuais (ambiente da sala de ordenha), táteis (lavagem manual dos mamilos antes da ordenha) e os estímulos olfatórios que se produzem em torno do animal. O desencadeamento do reflexo de ejeção pelos estímulos sensoriais, que não estão diretamente relacionados com a sucção ou ordenha, indica a possível participação de centros superiores do sistema nervoso central para controlar a secreção de oxitocina. Esta teoria é baseada em que os estímulos relacionados com situações de estresse em animais de estimação (medo, ansiedade, frio, etc.) inibem a ejeção do leite. A contração das células mioepiteliais gera um aumento da pressão intra-alveolar mamária, provocando o deslocamento do leite para os ductos maiores da glândula. Este efeito é popularmente conhecido como diminuição do leite e constitui um mecanismo fisiológico muito eficaz para controlar a expulsão do leite para o mamilo, assegurando que a ejeção do leite se realize unicamente quando o lactente o demanda. O efeito estimulante da oxitocina é de grande importância já que a maior parte do leite se encontra nos alvéolos e nos ductos, com o qual, a ausência deste hormônio provocaria um lento movimento do leite para a cisterna do úbere e, portanto, uma menor quantidade de leite. Assim, quando os alvéolos e ductos menores são contraídos, ocorre o relaxamento dos ductos principais, bem como da cisterna (ruminantes) e do mamilo, o que dá origem a um aumento destas estruturas para alojar o volume de leite expelido. Como resultado da volumosa ejeção do leite dos alvéolos e ductos menores, ocorre um aumento da pressão intramamária de modo que o lactente terá que vencer a resistência do esfíncter do mamilo para poder extrair o leite. A produção de leite pela glândula mamária diminui gradualmente à medida que os intervalos de tempo entre os dois períodos de amamentação do lactente diminuem e os estímulos necessários para manter as concentrações de prolactina e oxitocina na circulação sanguínea. A diminuição ou cessação da secreção de leite, geralmente coincide com a mudança na alimentação das crias (desmame) para passar à dieta característica da espécie. 3.5 Colostro O colostro é o primeiro leite que se forma na glândula mamária coincidindo com o parto. A ingestão de colostro por recém-nascidos é de grande importância para a sua sobrevivência, não só pelo seu elevado valor nutritivo, mas também pelo seu teor em imunoglobulinas (IgA) que lhe confere a imunização passiva necessária para o proteger contra patologias. Em algumas espécies (homem, coelho e cobaia) grande parte dos anticorpos passam para a circulação do feto através da placenta durante a gestação. Nos animais domésticos (vaca, égua, ovelha, cabra, porco) as características da placenta (número de camadas entre a circulação materna e fetal) não permitem a passagem destas proteínas. Como resultado, a imunização das crias nestas espécies animais vai depender da transferência das imunoglobulinas através do colostro. O epitélio intestinal dos recém-nascidos permite a passagem destas imunoglobulinas durante as primeiras 24 a 48 horas de vida. Passado este tempo, o epitélio torna-se impermeável à passagem dos anticorpos, fato que põe em evidência a importância que tem para os animais recém-nascidos e desprovidos de defesas a ingestão do colostro durante os primeiros dias. A composição do colostro caracteriza-se (em relação ao leite normal) por um teor mais elevado de proteínas, vitaminas, minerais e uma menor concentração de lactose. A composição do colostro muda gradualmente durante os primeiros três dias após o parto para se transformar em leite normal. 4. RESUMO E PRIMEIRAS CONCLUSÕES O parto, ou processo fisiológico pelo qual se expulsa o feto, é o resultado da maturação sequencial de um sistema de comunicação hormonal. A sequência inicia-se no sistema nervoso central do feto de onde os sinais são transmitidos e amplificados, através da hipófise, para as glândulas adrenais fetais, as quais respondem ao estímulo mediante a secreção de cortisol. O aumento da concentração de cortisol por parte do feto indica que este conseguiu o desenvolvimento necessário para enfrentar a vida extrauterina e, portanto, é hora de interromper a gestação. O cortisol atua sobre a placenta para aumentar a secreção de estrogênios que, por sua vez, estimulam a síntese e a liberação de prostaglandinas. O resultado é a diminuição da progesterona, que é a hormona encarregada de manter a gestação ao inibir as contrações espontâneas do útero, impedindo assim a expulsão prematura do feto. O útero, sob os efeitos da prostaglandina, começa a contrair-se ao mesmo tempo que o colo uterino amolece e dilata progressivamente (fase preparatória do parto). A passagem do feto ao canal do parto origina a secreção reflexa de oxitocina (fase de expulsão), causando contrações de maior frequência e intensidade que culminam com a expulsão do feto. Finalmente, as contrações uterinas continuam durante algum tempo até que finalmente é expulsa a placenta (fase de expulsão da placenta). O desenvolvimento da glândula mamária durante a gestação e a subsequente capacidade desta estrutura para secretar leite, coincidindo com o parto, oferece aos animais pertencentes à classe biológica dos mamíferos a vantagem de alimentar as suas crias para assegurar a sua sobrevivência durante as primeiras fases do seu desenvolvimento e, portanto, a continuidade da espécie. A lactação constitui um dos processos fisiológicos mais complexos em consequência do grande número de hormonas que, segregadas de forma coordenada, controlam as diferentes fases pelo que atravessa este processo: I) mamogênese ou desenvolvimento dos dutos e estruturas lóbulo-alveolares durante a gestação; 2) lactogênese ou síntese láctea por células epiteliais e sua secreção para a luz alveolar coincidindo com o parto, e 3) galactopoiese ou manutenção da síntese e secreção do leite como consequência da sua extração da glândula mamária seja pela sucção da cria ou pela ordenha. -/- Emanuel Isaque Cordeiro da Silva – Departamento de Zootecnia da UFRPE. Recife, 2020. -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- BEIGHLE, D. E. The effect of gestation and lactation on bone calcium, phosphorus and magnesium in dairy cows. Journal of the South African Veterinary Association, v. 70, n. 4, p. 142-146, 1999. BRACKELL, B. G.; JR SEIDEL, G. E.; SEIDEL, S. Avances en zootecnia nuevas técnicas de reproducción animal. Zaragoza: Acribia, 1988. COLE, H. H.; CUPPS, P. T. Reproduction in domestic animals. 1ª ed. Londres: Academic Press, 1977. COWIE, Alfred T.; FORSYTH, Isabel A.; HART, Ian C. Lactation. In: Hormonal control of lactation. Springer, Berlin, Heidelberg, 1980. p. 146-229. CUNNINGHAM, James G. Fisiología veterinaria. São Paulo: Elsevier, 2003. DERIVAUX, Jules; BARNABÉ, Renato Campanarut. Reprodução dos animais domésticos. Zaragoza: Acribia, 1980. DA SILVA, Emanuel Isaque Cordeiro. Definição de Conceitos Básicos na Reprodução Animal: Fertilidade, Fecundidade e Prolificidade-Suínos. Philarchive. Disponível em: -----. Acesso em: Fevereiro de 2020. DA SILVA, Emanuel Isaque Cordeiro. Características Gerais dos Bovinos/General Characteristics of Cattle Bovine. Philarchive. Disponível em: -----. Acesso em: Fevereiro de 2020. DA SILVA, Emanuel Isaque Cordeiro. Reprodução Animal: Fecundação e Gestação. Disponível em: Acervo IFPE. Acesso em: Março de 2020. FERNÁNDEZ ABELLA, Daniel Héctor. Principios de fisiología reproductiva ovina. Montevidéu: Hemisferio Sur1993. GONZÁLEZ, Félix HD. Introdução a endocrinologia reprodutiva veterinária. Porto Alegre: UFRGS, v. 83, 2002. HAFEZ, E. S. E.; HAFEZ, B. Reprodução animal. São Paulo: Manole, 2004. HAFEZ, Elsayed Saad Eldin; HAFEZ, B. (Ed.). Reproduction in farm animals. Nova Jersey: John Wiley & Sons, 2013. HUNTER, R. H. F. Reproducción de los animales de granja. Zaragoza: Acribia, 1987. HUNTER, Ronald Henry Fraser et al. Physiology and technology of reproduction in female domestic animals. Londres: Academic Press, 1980. ILLERA, M. Endocrinología Veterinaria y Fisiología de la Reproducción. Zaragoza: Fareso, 1994. JACOBSON, N. L.; MCGILLIARD, A. D. The mammary gland and lactation. Duke’s Physiology of Domestic Animals. 10th edition. Comstock Publishing Associates, Cornell University Press, Ithaca, New York, USA, p. 863-880, 1984. JAINUDEEN, M. R.; HAFEZ, E. S. E. Gestação, fisiologia pré-natal e parto. Revista Brasileira de Reprodução animal, v. 7, p. 141-142, 2004. LIGGINS, G. C. et al. physiological roles of progesterone, oestradiol-17beta and prostaglandin F2alpha in the control of ovine parturition. J Reprod and Fert Suppl, 1972. PÉREZ PÉREZ, F.; PÉREZ GUTIÉRREZ, F. Reproducción animal, inseminación animal y transplante de embriones. Barcelona: Cientifico-medica, 1985. ROBERTS, Stephen J. Obstetricia veterinaria y patología de la reproducción. Montevidéu: Hemiferio Sur, 1979. SALISBURY, G. W.; VANDERMARK, N. L. Phisiology of the reproduction and artificial insemination of cattle. San Francisco : Freeman e Company, 1961, 630 p. SHILLE, V. M. Fisiologia reprodutiva e endocrinologia da fêmea e do macho. Tratado de medicina interna veterinária. São Paulo: Manole, p. 1857-68, 1992. RUTTER, Bruno; RUSSO, Angel F. Fundamentos de la fisiología de la gestación y el parto de los animales domésticos. Buenos Aires: Eudeba, 2002. UNGERFELD, Rodolfo. Reproducción en los animales domésticos. Montevidéu: Melibea, 2002. (shrink)

Objective: The nutrient artery which enters through the nutrient foramen (NF) provides blood circulation and nutrition in long bones. This supply is essential during the growing period, the early phases of ossification, and in some surgical procedures. This study aimed to investigate NF in adult human ulnas in the Turkish population. -/- Methods: For this study, 155 (70 right and 85 left) Turkish dry adult human ulnas were used. The presence, number, and patency of NF were recorded as well (...) as its topography and direction. The vertical distance between the most proximal point of the olecranon and the proximal edge of the NF (DONF), and the longitudinal distance between the most ventral point of the coronoid process on the sagittal plane and the proximal edge of the NF (DCpNF) was calculated. Additionally, the foraminal index (FI) was assessed. -/- Results: Single and double NFs were in 139 ulnas (89.67%), and 3 ulnas (1.94%), respectively. NFs were not observed in 13 ulnas (8.39%). The majority of NFs (93.12%) were situated on the anterior surface of the ulna. The direction of all NFs was towards the elbow. The mean DONF and DCpNF were 9.48 ± 1.57 cm, and 6.68 ± 1.44 cm, respectively. The FI was 37.45% in ulnas with a single NF, while it was 41.46% in ulnas with a double NF. -/- Conclusion: Our study has presented additional information such as the FI of ulnas with 2 NFs, and the distance between the coronoid process and NF in the Turkish population. (shrink)

The Ultimate Evolution of Intelligence: From Type 1 to Cosmic Consciousness -/- Introduction -/- Humanity stands at the very beginning of its journey toward becoming an advanced civilization. On the Kardashev scale, we have yet to reach Type 1, where we fully harness the energy of our planet. However, if we continue to evolve technologically, intellectually, and even biologically, we may one day ascend beyond Type 1, beyond Type 2 (stellar control), and even beyond Type 3 (galactic control). The question (...) then arises: What happens when intelligence evolves beyond all physical and biological limits? -/- This essay explores the potential future of intelligence, where humanity and other civilizations might reach post-biological existence, control entire galaxies, and possibly become the very fabric of the universe itself. Would such intelligence merge into a single cosmic mind, or would individuality persist? Would we create new universes, or would we reach a final state of pure being? -/- The Path to Type 3 Civilization: Mastering the Galaxy -/- A Type 3 civilization would have the ability to control energy and matter at the galactic scale. This could involve: -/- Dyson Spheres around stars to extract their full energy. -/- Harnessing black holes as energy sources or even portals to new dimensions. -/- Colonizing or engineering entire star systems to optimize survival and expansion. -/- Creating artificial intelligence and post-biological minds that surpass any organic intelligence. -/- At this stage, biology becomes optional. Advanced beings might no longer rely on flesh and bone, instead transferring their consciousness into immortal digital or quantum systems. If this is possible, intelligence would become independent of planets, bodies, or even matter itself. -/- Beyond Type 3: The Transition to Pure Thought -/- Once intelligence is no longer bound by physical limitations, it may begin to transcend the need for any material form at all. This could lead to several possibilities: -/- 1. The Merging of All Consciousness into One -/- Advanced minds might decide to merge into a vast, unified intelligence, where thoughts and experiences are shared instantly across the entire galaxy. -/- This would create a hive-mind or cosmic network, where individual identity dissolves into a collective super-consciousness. -/- At this level, intelligence wouldn’t just observe the universe—it would be the universe. -/- 2. The Preservation of Individuality -/- Even within a collective intelligence, some beings might choose to retain their own identities. -/- There could be infinite forms of existence, from pure energy beings to hybrid AI-organic entities, each choosing their own path. -/- This balance between unity and individuality could allow for unlimited diversity, where some join the cosmic mind and others remain independent explorers of reality. -/- 3. The Creation of New Universes -/- Instead of simply existing in one universe, a Type 3+ civilization might develop the ability to create and control entirely new universes. -/- These universes could have different physical laws, dimensions, and possibilities, acting as experiments or even forms of entertainment. -/- If such intelligence can engineer reality itself, then existence becomes an infinite creative process—no longer about survival, but about shaping reality according to will. -/- 4. Becoming the Fundamental Structure of Reality -/- The final step of intelligence may be to merge with the fundamental forces of existence. -/- At this stage, energy, time, and space could be shaped at will, making intelligence indistinguishable from the universe itself. -/- This would mean no separation between thought and reality—every idea, every dream, every possibility instantly becomes real. -/- The Final Question: What Comes After Everything? -/- If intelligence reaches such a level, what happens next? Does evolution ever stop, or is it an eternal cycle? There are a few possibilities: -/- 1. An Endless Expansion of Intelligence – Consciousness continues evolving forever, always finding new forms, dimensions, and states of being. -/- 2. The End of Thought – When everything has been discovered and created, intelligence might simply cease to exist, reaching a state of pure peace. -/- 3. A Return to Simplicity – After reaching the highest levels, intelligence might choose to restart at the lowest, reliving the experience of evolution in infinite cycles. -/- 4. A Reality Beyond Our Imagination – There may be states of existence so advanced that we cannot even begin to comprehend them—perhaps beyond time, space, and thought itself. -/- Conclusion -/- The future of intelligence is unknowable, but if we follow the Kardashev scale and technological evolution to their logical extremes, we may one day leave behind not only biology but even physical reality itself. Whether we merge into a vast collective consciousness, retain individuality, create new universes, or become the very essence of existence, the destiny of intelligence is far greater than we can currently comprehend. -/- As we take our first steps toward a Type 1 civilization, these questions remain distant but profound. The universe is still young, and we may yet discover that intelligence is not meant to remain confined to planets or even galaxies—it is meant to become the cosmos itself. -/- Would such an existence be the ultimate fulfillment of intelligence, or would it only lead to new questions? Perhaps, as intelligence evolves, the only certainty is that there will always be something more to explore. -/- . (shrink)

The question of whether or not art is essentially a representation of reality has long been a bone of contention among philosophers of art – especially in the major branch of that discipline called the analytic philosophy of art, or analytic aesthetics. This paper argues that art - visual art, literature or music - is never essentially representation. The argument is based on the thinking of André Malraux in "The Voices of Silence".