This paper defines the form of prior knowledge that is required for sound inferences by analogy and single-instance generalizations, in both logical and probabilistic reasoning. In the logical case, the first order determination rule defined in Davies (1985) is shown to solve both the justification and non-redundancy problems for analogical inference. The statistical analogue of determination that is put forward is termed 'uniformity'. Based on the semantics of determination and uniformity, a third notion of "relevance" is defined, both logically (...) and probabilistically. The statistical relevance of one function in determining another is put forward as a way of defining the value of information: The statistical relevance of a function F to a function G is the absolute value of the change in one's information about the value of G afforded by specifying the value of F. This theory provides normative justifications for conclusions projected by analogy from one case to another, and for generalization from an instance to a rule. The soundness of such conclusions, in either the logical or the probabilistic case, can be identified with the extent to which the corresponding criteria (determination and uniformity) actually hold for the features being related. (shrink)

We analyze the logical form of the domain knowledge that grounds analogical inferences and generalizations from a single instance. The form of the assumptions which justify analogies is given schematically as the "determination rule", so called because it expresses the relation of one set of variables determining the values of another set. The determination relation is a logical generalization of the different types of dependency relations defined in database theory. Specifically, we define determination as a relation between schemata of first (...) order logic that have two kinds of free variables: (1) object variables and (2) what we call "polar" variables, which hold the place of truth values. Determination rules facilitate sound rule inference and valid conclusions projected by analogy from single instances, without implying what the conclusion should be prior to an inspection of the instance. They also provide a way to specify what information is sufficiently relevant to decide a question, prior to knowledge of the answer to the question. (shrink)

We describe and try to motivate our project to build systems using both a knowledge based and a neural network approach. These two approaches are used at different stages in the solution of a problem, instead of using knowledge bases exclusively on some problems, and neural nets exclusively on others. The knowledge base (KB) is defined first in a declarative, symbolic language that is easy to use. It is then compiled into an efficient neural network (NN) representation, run, and the (...) results from run time and (eventually) from learning are decompiled to a symbolic description of the knowledge contained in the network. After inspecting this recovered knowledge, a designer would be able to modify the KB and go through the whole cycle of compiling, running, and decompiling again. The central question with which this project is concerned is, therefore, How do we go from a KB to an NN, and back again? We are investigating this question by building tools consisting of a repertoire of language/translation/network types, and trying them on problems in a variety of domains. (shrink)

In the TACITUS project for using commonsense knowledge in the understanding of texts about mechanical devices and their failures, we have been developing various commonsense theories that are needed to mediate between the way we talk about the behavior of such devices and causal models of their operation. Of central importance in this effort is the axiomatization of what might be called commonsense metaphysics. This includes a number of areas that figure in virtually every domain of discourse, such as granularity, (...) scales, time, space, material, physical objects, shape, causality, functionality, and force. Our effort has been to construct core theories of each of these areas, and then to define, or at least characterize, a large number of lexical items in terms provided by the core theories. In this paper we discuss our methodological principles and describe the key ideas in the various domains we are investigating. (shrink)

Перевод статьи: Davies T., Chandler R. Online deliberation design: Choices, criteria, and evidence // Democracy in motion: Evaluating the practice and impact of deliberative civic engagement / Nabatchi T., Weiksner M., Gastil J., Leighninger M. (eds.). -- Oxford: Oxford univ. press, 2013. -- P. 103-131. А. Кулик. -/- Вниманию читателей предлагается обзор эмпирических исследований в области дизайна онлайн-форумов, предназначенных для вовлечения граждан в делиберацию. Размерности дизайна определены для различных характеристик делиберации: назначения, целевой аудитории, разобщенности участников в пространстве и во (...) времени, среды коммуникации и организации делиберативного процесса. После краткого обзора критериев оценки вариантов дизайна рассматриваются эмпирические данные, соотносящиеся с каждым из вариантов. Эффективность онлайн-делиберации зависит от того, насколько условия коммуникации соотносятся с заданиями делиберации. Компромиссы, как, например, между анонимным или идентифицируемым участием, предполагают различные дизайны в зависимости от цели делиберации и состава участников. Выводы исследования получены на материале существующих технологий и могут измениться по мере коэволюции технологий и пользователей. (shrink)

Human development is meant to be transformational in that it aims to improve people's lives by enhancing their capabilities. But who does it target: people as they are or the people they will become? This paper argues that the human development approach relies on an understanding of personal identity as dynamic rather than as static collections of preferences, and that this distinguishes human development from conventional approaches to development. Nevertheless, this dynamic understanding of personal identity is presently poorly conceptualized and (...) this has implications for development practice. We identify a danger of paternalism and propose institutionalizing two procedural principles as side constraints on development policies and projects: the principle of free prior informed consent and the principle of democratic development. -/- . (shrink)

Can new technology enhance purpose-driven, democratic dialogue in groups, governments, and societies? Online Deliberation: Design, Research, and Practice is the first book that attempts to sample the full range of work on online deliberation, forging new connections between academic research, technology designers, and practitioners. Since some of the most exciting innovations have occurred outside of traditional institutions, and those involved have often worked in relative isolation from each other, work in this growing field has often failed to reflect the full (...) set of perspectives on online deliberation. This volume is aimed at those working at the crossroads of information/communication technology and social science, and documents early findings in, and perspectives on, this new field by many of its pioneers. -/- CONTENTS: -/- Introduction: The Blossoming Field of Online Deliberation (Todd Davies, pp. 1-19) -/- Part I - Prospects for Online Civic Engagement -/- Chapter 1: Virtual Public Consultation: Prospects for Internet Deliberative Democracy (James S. Fishkin, pp. 23-35) -/- Chapter 2: Citizens Deliberating Online: Theory and Some Evidence (Vincent Price, pp. 37-58) -/- Chapter 3: Can Online Deliberation Improve Politics? Scientific Foundations for Success (Arthur Lupia, pp. 59-69) -/- Chapter 4: Deliberative Democracy, Online Discussion, and Project PICOLA (Public Informed Citizen Online Assembly) (Robert Cavalier with Miso Kim and Zachary Sam Zaiss, pp. 71-79) -/- Part II - Online Dialogue in the Wild -/- Chapter 5: Friends, Foes, and Fringe: Norms and Structure in Political Discussion Networks (John Kelly, Danyel Fisher, and Marc Smith, pp. 83-93) -/- Chapter 6: Searching the Net for Differences of Opinion (Warren Sack, John Kelly, and Michael Dale, pp. 95-104) -/- Chapter 7: Happy Accidents: Deliberation and Online Exposure to Opposing Views (Azi Lev-On and Bernard Manin, pp. 105-122) -/- Chapter 8: Rethinking Local Conversations on the Web (Sameer Ahuja, Manuel Pérez-Quiñones, and Andrea Kavanaugh, pp. 123-129) -/- Part III - Online Public Consultation -/- Chapter 9: Deliberation in E-Rulemaking? The Problem of Mass Participation (David Schlosberg, Steve Zavestoski, and Stuart Shulman, pp. 133-148) -/- Chapter 10: Turning GOLD into EPG: Lessons from Low-Tech Democratic Experimentalism for Electronic Rulemaking and Other Ventures in Cyberdemocracy (Peter M. Shane, pp. 149-162) -/- Chapter 11: Baudrillard and the Virtual Cow: Simulation Games and Citizen Participation (Hélène Michel and Dominique Kreziak, pp. 163-166) -/- Chapter 12: Using Web-Based Group Support Systems to Enhance Procedural Fairness in Administrative Decision Making in South Africa (Hossana Twinomurinzi and Jackie Phahlamohlaka, pp. 167-169) -/- Chapter 13: Citizen Participation Is Critical: An Example from Sweden (Tomas Ohlin, pp. 171-173) -/- Part IV - Online Deliberation in Organizations -/- Chapter 14: Online Deliberation in the Government of Canada: Organizing the Back Office (Elisabeth Richard, pp. 177-191) -/- Chapter 15: Political Action and Organization Building: An Internet-Based Engagement Model (Mark Cooper, pp. 193-202) -/- Chapter 16: Wiki Collaboration Within Political Parties: Benefits and Challenges (Kate Raynes-Goldie and David Fono, pp. 203-205) -/- Chapter 17: Debian’s Democracy (Gunnar Ristroph, pp. 207-211) -/- Chapter 18: Software Support for Face-to-Face Parliamentary Procedure (Dana Dahlstrom and Bayle Shanks, pp. 213-220) -/- Part V - Online Facilitation -/- Chapter 19: Deliberation on the Net: Lessons from a Field Experiment (June Woong Rhee and Eun-mee Kim, pp. 223-232) -/- Chapter 20: The Role of the Moderator: Problems and Possibilities for Government-Run Online Discussion Forums (Scott Wright, pp. 233-242) -/- Chapter 21: Silencing the Clatter: Removing Anonymity from a Corporate Online Community (Gilly Leshed, pp. 243-251) -/- Chapter 22: Facilitation and Inclusive Deliberation (Matthias Trénel, pp. 253-257) -/- Chapter 23: Rethinking the ‘Informed’ Participant: Precautions and Recommendations for the Design of Online Deliberation (Kevin S. Ramsey and Matthew W. Wilson, pp. 259-267) -/- Chapter 24: PerlNomic: Rule Making and Enforcement in Digital Shared Spaces (Mark E. Phair and Adam Bliss, pp. 269-271) -/- Part VI - Design of Deliberation Tools -/- Chapter 25: An Online Environment for Democratic Deliberation: Motivations, Principles, and Design (Todd Davies, Brendan O’Connor, Alex Cochran, Jonathan J. Effrat, Andrew Parker, Benjamin Newman, and Aaron Tam, pp. 275-292) -/- Chapter 26: Online Civic Deliberation with E-Liberate (Douglas Schuler, pp. 293-302) -/- Chapter 27: Parliament: A Module for Parliamentary Procedure Software (Bayle Shanks and Dana Dahlstrom, pp. 303-307) -/- Chapter 28: Decision Structure: A New Approach to Three Problems in Deliberation (Raymond J. Pingree, pp. 309-316) -/- Chapter 29: Design Requirements of Argument Mapping Software for Teaching Deliberation (Matthew W. Easterday, Jordan S. Kanarek, and Maralee Harrell, pp. 317-323) -/- Chapter 30: Email-Embedded Voting with eVote/Clerk (Marilyn Davis, pp. 325-327) -/- Epilogue: Understanding Diversity in the Field of Online Deliberation (Seeta Peña Gangadharan, pp. 329-358). -/- For individual chapter downloads, go to odbook.stanford.edu. (shrink)

“Violence” and “nonviolence” are, increasingly, misleading translations for the Sanskrit words hiṃsā and ahiṃsā—used by Gandhi as the basis for his philosophy of satyāgraha. I argue for rereading hiṃsā as “maleficence” and ahiṃsā as “beneficence.” These two more mind-referring English words capture the primacy of intention implied by Gandhi’s core principles. Reflecting a political turn in moral accountability detectable through linguistic data, both the scope and the usage of the word “violence” have expanded dramatically, making it harder to convincingly characterize (...) people and actions as “nonviolent.” New terminology could clarify the distinction between hiṃsā and ahiṃsā, and, thereby, prevent misunderstandings of Gandhi. Training in beneficence would reflect Gandhi’s psychological path to reducing avoidable harm: ego-detachment, universal love, and seeking truth by experiment. -/- NOTE: An extended, unpublished version, with additional arguments and evidence, is also available on PhilPapers as "The Primacy of Intention and the Duty to Truth: A Gandhi-Inspired Argument for Retranslating Hiṃsā and Ahiṃsā, with Connections to History, Ethics, and Civil Resistance". (shrink)

The words "violence" and "nonviolence" are increasingly misleading translations for the Sanskrit words hiṃsā and ahiṃsā -- which were used by Gandhi as the basis for his philosophy of satyāgraha. I argue for re-reading hiṃsā as “maleficence” and ahiṃsā as “beneficence.” These two more mind-referring English words – associated with religiously contextualized discourse of the past -- capture the primacy of intention implied by Gandhi’s core principles, better than “violence” and “nonviolence” do. Reflecting a political turn in moral accountability detectable (...) through linguistic data, both the scope and the usage of the word “violence” have expanded dramatically. The expanded scope of “violence” reflects greater consciousness of the various forms that serious harm can take, but also makes it harder to convincingly characterize people and actions as “nonviolent.” New translations could clarify the distinction between hiṃsā and ahiṃsā, and thereby prevent some misunderstandings of Gandhi. Training in beneficence would reflect Gandhi’s psychological path to reducing avoidable harm: detachment from the ego, learning to love universally, and seeking truth by experiment. (shrink)

This essay (a revised version of my undergraduate honors thesis at Stanford) constructs a theory of analogy as it applies to argumentation and reasoning, especially as used in fields such as philosophy and law. The word analogy has been used in different senses, which the essay defines. The theory developed herein applies to analogia rationis, or analogical reasoning. Building on the framework of situation theory, a type of logical relation called determination is defined. This determination relation solves a puzzle about (...) analogy in the context of logical argument, namely, whether an analogous situation contributes anything logically over and above what could be inferred from the application of prior knowledge to a present situation. Scholars of reasoning have often claimed that analogical arguments are never logically valid, and that they therefore lack cogency. However, when the right type of determination structure exists, it is possible to prove that projecting a conclusion inferred by analogy onto the situation about which one is reasoning is both valid and non-redundant. Various other properties and consequences of the determination relation are also proven. Some analogical arguments are based on principles such as similarity, which are not logically valid. The theory therefore provides us with a way to distinguish between legitimate and illegitimate arguments. It also provides an alternative to procedures based on the assessment of similarity for constructing analogies in artificial intelligence systems. (shrink)

Interest has been revived in the creation of a "bill of rights" for Internet users. This paper analyzes users' rights into ten broad principles, as a basis for assessing what users regard as important and for comparing different multi-issue Internet policy proposals. Stability of the principles is demonstrated in an experimental survey, which also shows that freedoms of users to participate in the design and coding of platforms appear to be viewed as inessential relative to other rights. An analysis of (...) users' rights frameworks that have emerged over the past twenty years similarly shows that such proposals tend to leave out freedoms related to software platforms, as opposed to user data or public networks. Evaluating policy frameworks in a comparative analysis based on prior principles may help people to see what is missing and what is important as the future of the Internet continues to be debated. (shrink)

This paper argues that private property and rights assignment, especially as applied to communication infrastructure and information, should be informed by advances in both technology and our understanding of psychology. Current law in this area in the United States and many other jurisdictions is founded on assumptions about human behavior that have been shown not to hold empirically. A joint recognition of this fact, together with an understanding of what new technologies make possible, leads one to question basic assumptions about (...) how law is made and what laws we should have in a given area, if any. I begin by analyzing different aspects of U.S. law, from a high-level critique of law making to a critique of rights assignment for what I call 'simple nonrival goods.' I describe my understanding, as a non-lawyer with a background in psychology and computing, of the current conventions in U.S. law, consider the foundational assumptions that justify current conventions, describe advances in psychology and technology that call these conventions into question, and briefly note how the law might normatively change in this light. I then apply this general analysis to the question of domain name assignment by the Internet Corporation for Assigned Names and Numbers (ICANN). (shrink)

This chapter reviews empirical evidence bearing on the design of online forums for deliberative civic engagement. Dimensions of design are defined for different aspects of the deliberation: its purpose, the target population, the spatiotemporal distance separating participants, the communication medium, and the deliberative process to be followed. After a brief overview of criteria for evaluating different design options, empirical findings are organized around design choices. Research has evolved away from treating technology for online deliberation dichotomously (either present or not) toward (...) nuanced findings that differentiate between technological features, ways of using them, and cultural settings. The effectiveness of online deliberation depends on how well the communicative environment is matched to the deliberative task. Tradeoffs, e.g. between rich and lean media and between anonymous and identifiable participation, suggest different designs depending on the purpose and participants. Findings are limited by existing technologies, and may change as technologies and users co-evolve. (shrink)

Online deliberation is one important instance of civic tech that is both for and by the citizens, through engaging citizens in Internet-supported deliberative discussions on public issues. This article explains the origins of a set of symposium articles in this journal issue based on the 2017 'International Conference on Deliberation and Decision Making: Interdisciplinary Perspectives on Civic Tech' held in Singapore. Symposium articles are presented in a sequence that flows from designing decision making systems to platforms to specific technological nudges.

This is a review of Susan Greenfield's 2015 book 'Mind Change: How Digital Technologies Are Leaving Their Mark On Our Brains'. Greenfield is a neuroscientist and a member of the UK House of Lords, who argues that digital technologies are changing the human environment "in an unprecedented way," and that by adapting to this environment, "the brain may also be changing in an unprecedented way." The book and its author have created a surprising amount of controversy. I discuss both Greenfield's (...) book and a prominent critique by Bell et al. (2015). The exchange points to some flaws in Greenfield's argument and represents an interesting debate about the public role of scientists, but it does not undermine the value of the book as a springboard for discussions about possible policies and future research. (shrink)

Although successive generations of digital technology have become increasingly powerful in the past 20 years, digital democracy has yet to realize its potential for deliberative transformation. The undemocratic exploitation of massive social media systems continued this trend, but it only worsened an existing problem of modern democracies, which were already struggling to develop deliberative infrastructure independent of digital technologies. There have been many creative conceptions of civic tech, but implementation has lagged behind innovation. This article argues for implementing one such (...) vision of digital democracy through the establishment of a public corporation. Modeled on the Corporation for Public Broadcasting in the United States, this entity would foster the creation of new digital technology by providing a stable source of funding to nonprofit technologists, interest groups, civic organizations, government, researchers, private companies, and the public. Funded entities would produce and maintain software infrastructure for public benefit. The concluding sections identify what circumstances might create and sustain such an entity. (shrink)

Coordination is a key problem for addressing goal–action gaps in many human endeavors. We define interpersonal coordination as a type of communicative action characterized by low interpersonal belief and goal conflict. Such situations are particularly well described as having collectively “intelligent”, “common good” solutions, viz., ones that almost everyone would agree constitute social improvements. Coordination is useful across the spectrum of interpersonal communication—from isolated individuals to organizational teams. Much attention has been paid to coordination in teams and organizations. In this (...) paper we focus on the looser interpersonal structures we call active support networks, and on technology that meets their needs. We describe two needfinding investigations focused on social support, which examined four application areas for improving coordination in ASNs: academic coaching, vocational training, early learning intervention, and volunteer coordination; and existing technology relevant to ASNs. We find a thus-far unmet need for personal task management software that allows smooth integration with an individual’s active support network. Based on identified needs, we then describe an open architecture for coordination that has been developed into working software. The design includes a set of capabilities we call “social prompting”, as well as templates for accomplishing multi-task goals, and an engine that controls coordination in the network. The resulting tool is currently available and in continuing development. We explain its use in ASNs with an example. Follow-up studies are underway in which the technology is being applied in existing support networks. (shrink)

The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we (...) identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies. (shrink)

Until recently, psychologists have conceptualised and studied trust in God (TIG) largely in isolation from contemporary work in theology, philosophy, history, and biblical studies that has examined the topic with increasing clarity. In this article, we first review the primary ways that psychologists have conceptualised and measured TIG. Then, we draw on conceptualizations of TIG outside the psychology of religion to provide a conceptual map for how TIG might be related to theorised predictors and outcomes. Finally, we provide a research (...) agenda for future empirical work in this area, as well as practical applications for counsellors and religious leaders. (shrink)

Cyber attackers targeting large corporations achieved a high perimeter penetration success rate during 2013, resulting in many corporations incurring financial losses. Corporate information technology leaders have a fiduciary responsibility to implement information security domain processes that effectually address the challenges for preventing and deterring information security breaches. Grounded in corporate governance theory, the purpose of this correlational study was to examine the relationship between strategic alignment, resource management, risk management, value delivery, performance measurement implementations, and information security governance (ISG) effectiveness (...) in United States-based corporations. Surveys were used to collect data from 95 strategic and tactical leaders of the 500 largest for-profit United States headquartered corporations. The results of the multiple linear regression indicated the model was able to significantly predict ISG effectiveness, F(5, 89) = 3.08, p = 0.01, R² = 0.15. Strategic alignment was the only statistically significant (t = 2.401, p <= 0.018) predictor. The implications for positive social change include the potential to constructively understand the correlates of ISG effectiveness, thus increasing the propensity for consumer trust and reducing consumers' costs. (shrink)

Invited discussion paper on Patrick Todd's book, _The Open Future: Why Future Contingents Are All False_ (Oxford, 2021).

In this article, I will be focusing specifically on cryopreservation and two of the American biotechnomedical tenets introduced by Robbie Davis-Floyd and Gloria St. John in their technocratic model of medicine: the “body as machine” and “death as defeat.” These axioms are embraced by both the biotechnomedical establishment as well as the cryopreservation communities when they discuss the future of humankind. In particular, I will be focusing on the political economy of cryopreservation as an embodiment of American neoliberalism—as well as (...) a Durkheimian death ritual—in the twenty-first century. Finally, I will theorize on a future populated by human beings from “the past” and the implications and consequences that may be caused by contemporary humans experiencing a temporal shift from traveling in deep time vis-à-vis cryopreservation. (shrink)

Obstacles to achieving a global climate treaty include disagreements about questions of justice raised by the UNFCCC's principle that countries should respond to climate change by taking cooperative action "in accordance with their common but differentiated responsibilities and respective capabilities and their social and economic conditions". Aiming to circumvent such disagreements, Climate Change Justice authors Eric Posner and David Weisbach argue against shaping treaty proposals according to requirements of either distributive or corrective justice. The USA's climate envoy, Todd Stern, (...) takes a similar position. In this article I explain the practical and theoretical drawbacks of Posner & Weisbach's welfarist perspective and propose an alternative. I show that their arguments fail to rule out John Rawls' non-utilitarian, political conception of international justice and human rights, the Law of Peoples. On this basis I develop a conception of climate justice that highlights implications of some of Rawls' principles and adds a principle for determining fair shares of climate -treaty-related benefits and burdens. I propose this conception as a moral framework for negotiating a treaty that would promote human welfare consistently with requirements of justice, and I argue that a treaty proposal satisfying these requirements could best satisfy Posner & Weisbach's own feasibility criteria. (shrink)

This is a reply to the commentaries on my paper 'Truthmaker Semantics for Natural Language: Attitude Verbs, Modals, and Intensional Transitive Verbs'. The paper is a commissioned 'target' article, with commentaries by W. Davis, B. Arsenijevic, K. Moulton, K. Liefke, M. Kaufman, R. Matthews, P. Portner and A. Rubinstein, P. Elliott, and G. Ramchand.

The book presents the first comprehensive survey of limits of the intentional control of action from an interdisciplinary perspective. It brings together leading scholars from philosophy, psychology, and the law to elucidate this theoretically and practically important topic from a variety of theoretical and disciplinary approaches. It provides reflections on conceptual foundations as well as a wealth of empirical data and will be a valuable resource for students and researchers alike. Among the authors: Clancy Blair, Todd S. Braver, Michael (...) W. Cole, Anika Fäsche, Maayan Davidov, Peter Gollwitzer, Kai Robin Grzyb, Tobias Heikamp, Gabriele Oettingen, Rachel McKinnon, Nachschon Meiran, Hans Christian Röhl, Michael Schmitz, John R. Searle, Gottfried Seebaß, Gisela Trommsdorff, Felix Thiede, J. Lukas Thürmer, Frank Wieber. (shrink)

This paper gives an outline of truthmaker semantics for natural language against the background of standard possible-worlds semantics. It develops a truthmaker semantics for attitude reports and deontic modals based on an ontology of attitudinal and modal objects and on a semantic function of clauses as predicates of such objects. It also présents new motivations for 'object-based truthmaker semantics' from intensional transitive verbs such as ‘need’, ‘look for’, ‘own’, and ‘buy’ and gives an outline of their semantics. This paper is (...) a commissioned 'target' article, with commentaries by W. Davis, B. Arsenijevic, K. Moulton, K. Liefke, M. Kaufmann, R. Matthews, P. Portner and A. Rubinstein, P. Elliott, G. Ramchand and my reply. (shrink)

Revista IT & C este o publicație trimestrială din domeniile tehnologiei informației și comunicații, și domenii conexe de studiu și practică. -/- Cuprins: -/- EDITORIAL Cu sau fără Internet?, de Nicolae Sfetcu Supremația tehnologiilor IT&C, de Nicolae Sfetcu -/- TEHNOLOGIA INFORMAȚIEI Tehnologia blockchain, de Nicolae Sfetcu Ciclul de viață al inteligenței artificiale, de Nicolae Sfetcu -/- TELECOMUNICAȚII Rețelele de comunicații 5G, de Nicolae Sfetcu Proiectarea și arhitectura rețelelor de comunicații 5G, de Nicolae Sfetcu -/- INTERNET Megadatele (Big Data) pe Internet, (...) de Nicolae Sfetcu Cum funcționează Internetul, de Michael Mendez -/- SOFTWARE Deschideți / Creați o imagine în Adobe Photoshop, de Nicolae Sfetcu Excel: Comenzi rapide și formatare de bază, de Nicolae Sfetcu -/- PROGRAMARE Utilizarea limbajului de programare R în știința datelor cu RStudio, de Rafael A. Irizarry Tipuri de date atomice în Python, de Stephen Davies -/- DEZVOLTARE WEB Servere web, de Michael Mendez Variabile în dezvoltarea WordPress, de Nicolae Sfetcu -/- SECURITATE CIBERNETICĂ Securitatea informațiilor în lucrul cu megadate pe Internet, de Nicolae Sfetcu Securitatea Big Data: Amenințări, de Nicolae Sfetcu -/- AFACERI ONLINE Proiectarea și modelarea tehnologiei blockchain – Bitcoin, de Nicolae Sfetcu Marketing de conţinut, de Nicolae Sfetcu -/- MEDIA Analitica rețelelor sociale, de Nicolae Sfetcu Cercetare și aplicații în rețelele sociale, de Bogdan Batrinca și Philip C Treleaven -/- ISSN 2971 – 9097 ISSN-L 2821 – 8469, DOI: 10.58679/IT89910. (shrink)

Introduction In 2013, Dr. J. Muizelaar and Dr. R. Schrot, two neurosurgeons at the University of California Davis Medical Center (UCDMC), were found guilty of research misconduct due to failure to comply with institutional policies as well as Food and Drug Administration (FDA) regulations governing human subjects research. At issue here, however, is the difference between research and innovative therapy in the clinical setting of patient care where clinical judgment is reasonably to be privileged. Methods The UCDMC investigative document is (...) reviewed along with standard literature on clinical ethics and clinical data about glioblastoma multiforme (GBM) cancer. Results In this paper I argue that, by tendentiously focusing on policies, regulations, and procedures governing human subjects research, the UCDMC investigation failed to account for the centrality of clinical judgment and clinical ethics pertinent to judicious review of this matter, especially given the unique clinical context of terminally ill patients having exhausted standard care treatment options for glioblastoma multiforme (GBM) cancer. Conclusions The UCDMC investigation raises serious problems for clinicians who are engaged in innovative therapy in the clinical setting, requiring a regulatory framework separate from the normal Institutional Review Board (IRB) process. (shrink)

PRINCÍPIOS DA DIGESTÃO DOS ALIMENTOS NOS BEZERROS -/- -/- E. I. C. da Silva -/- Departamento de Agropecuária – IFPE Campus Belo Jardim -/- Departamento de Zootecnia – UFRPE sede -/- -/- PRINCÍPIOS DA DIGESTÃO DOS ALIMENTOS NOS BEZERROS -/- -/- INTRODUÇÃO -/- Se todos os bezerros pudessem ser criados por suas mães, haveria pouca necessidade de inúmeros livros, artigos e trabalhos, como esse, sobre a criação e o manejo básico desses animais. A maioria das vacas desempenha um ótimo papel (...) na criação dos seus descendentes, desde que sejam tomados os devidos cuidados com relação a alimentação, saúde e a outros aspectos relativos à criação desses neonatos. A essência da pecuária bovina relativa à criação de bezerros é manter esses animais vivos e aptos o suficiente para desempenhar atividades produtivas de grande importância na propriedade. Para tanto, os criadores necessitam entender o desenvolvimento do trato digestivo do bezerro e os conceitos básicos da digestão dos alimentos por ele, e é isso que pretendo aclarar de forma clara e concisa com esse trabalho. -/- -/- 1.1 O TRATO DIGESTIVO DO BEZERRO -/- Um animal adulto necessita de quatro estômagos funcionais para dar-lhe a capacidade de utilizar a ampla gama de alimentos disponíveis. -/- O retículo e o rúmen abrigam milhões de micróbios que fermentam e digerem o material vegetal, em especial às presentes nas forragens. O omaso permite a absorção de água do conteúdo do intestino. O abomaso, ou quarto estômago, é o verdadeiro estômago, comparável ao dos humanos, e permite a digestão ácida dos alimentos. -/- O bezerro muito jovem não desenvolve a capacidade de digerir o pasto, sendo assim o abomaso é o único estômago funcional ao nascer. Tanto os animais recém-nascidos como os adultos têm um intestino delgado funcional que permite a digestão alcalina dos alimentos. -/- A figura 1 ilustra a anatomia dos estômagos e intestino delgado de um bezerro recém-nascido. Esse diagrama esquemático mostra as dimensões relativas dos quatro estômagos, o sulco esofágico, que vai do esôfago até o abomaso, e o esfíncter pilórico ou válvula no fundo do abomaso, que controla a velocidade de movimento do conteúdo do intestino no duodeno. -/- O omaso e o abomaso representam cerca de 70% da capacidade total do estômago no bezerro recém-nascido. Por outro lado, nas vacas adultas, eles compõem apenas 30% da capacidade total do estômago (figura 2). -/- A digestão dos alimentos é auxiliada pela secreção de certos produtos químicos denominados enzimas, que estão presentes nas várias partes do intestino. Por exemplo, os bezerros produzem a enzima renina na parede do abomasal para auxiliar na digestão das proteínas do leite, enquanto a lactase é produzida na parede do duodeno para a digestão do açúcar do leite (lactose). Estas enzimas operam mais eficazmente em diferentes níveis de acidez no conteúdo do intestino, ácido no abomaso e alcalino no duodeno. Para conseguir isso, o bezerro segrega eletrólitos, ou sais minerais, com as enzimas, para mudar o conteúdo do intestino de um tipo para outro. -/- Os produtos finais da digestão dos diferentes componentes dos alimentos são absorvidos através da parede do intestino, mediante as vilosidades intestinais, para a corrente sanguínea, onde são levados para as diferentes partes do corpo para o crescimento e desenvolvimento do animal. -/- -/- 1.2 O BEZERRO ALIMENTADO COM LEITE -/- O Leite ou substituto do leite, quer seja apreendido através de uma teta ou bebido de um balde, é canalizado do esôfago através do sulco esofágico para o abomaso. Este sulco é um pequeno canal na parede do rúmen que é controlado por músculos que permitem que os líquidos sejam diretamente enviados para o abomaso e que não entrem no rúmen. O sulco é ativado em resposta a diferentes estímulos. Funciona bem quando os bezerros amamentam-se através das tetas das mães, mas às vezes não funciona quando bebem de um balde. Essa parece ser uma condição psicológica em resposta aos bezerros separados de suas mães. A maioria dos bezerros podem ser treinados pelo tratador para beber o leite do balde rapidamente e bem, a metodologia empregada é a da persuasão do animal, ao qual o mesmo possa responder positivamente à nova rotina diária e à mãe substituta na forma do criador do bezerro. Quando o leite ou o substituto do leite entra no abomaso, forma um coágulo firme dentro de alguns minutos sob a influência das enzimas renina e pepsina. Este é o mesmo processo envolvido na fabricação de queijo ou junket, usando renina para coagular a proteína do leite. A coagulação do leite retarda a taxa em que flui para fora do abomaso, permitindo assim uma liberação constante de nutrientes alimentares em todo o intestino e, eventualmente, para a corrente sanguínea. Pode levar de 12 a 18 horas para que a coalhada de leite seja totalmente digerida. -/- As enzimas que atuam nas proteínas do leite requerem um ambiente ácido e esse é fornecido pela secreção do ácido clorídrico no abomaso. No entanto, até que a digestão ácida esteja operando de forma eficiente, e isso pode levar até sete dias, a única forma de proteína que pode ser digerida é a caseína. Não há substituto para a caseína no bezerro muito jovem. Os substitutos do leite que contêm outras formas de proteína não podem ser devidamente digeridos até que os bezerros sejam mais velhos. Logo, é necessário muito cuidado para não fornecer substitutos ou sucedâneos que contenham fontes proteicas que não possam ser digeridas pelo estômago do animal, para que não ocasione complicações gastrintestinais. -/- A digestão do leite pode ser melhorada com a inclusão de coalho, que pode ser obtido a partir de fábricas de queijo ou aditivos comerciais de leite de bezerro para a primeira semana ou mais. Esses produtos comerciais podem fornecer ácidos adicionais para reduzir o pH abomasal e incrementar a quantidade de enzimas e bactérias específicas para aumentar a taxa de degradação da coalhada de leite. Tais aditivos são chamados probióticos, na medida em que ajudam nos processos digestivos normais. A pesquisa nem sempre os encontrou para melhorar o desempenho e a saúde dos bezerros, e eles são mais propensos a ser benéficos quando os bezerros estão sofrendo de problemas de saúde. Além disso, a sua eficácia, em termos de custo-benefício é, por vezes, questionada. -/- Qualquer leite de uma alimentação anterior está envolvido neste coágulo recém-formado. As proteínas líquidas de soro de leite e a lactose são rapidamente separadas da coalhada de leite e passam para o abomaso. A gordura do leite contida na coalhada de leite é decomposta por outra enzima, a lipase. Esta é secretado na boca pela saliva e incorporada quando o leite é engolido. A alimentação pelas tetas em vez da alimentação através do balde parece produzir mais saliva e, portanto, mais lipase. A digestão adicional da proteína do leite e da gordura ocorre no duodeno com a ajuda das enzimas produzidas no pâncreas. -/- A lactose, que é rapidamente liberada da coalhada de leite no abomaso, é dividida em glicose e galactose e estas são absorvidas na corrente sanguínea para formar a principal fonte de energia para os bezerros jovens. -/- As gorduras são divididas em ácidos graxos e glicerol para absorção e uso como energia, enquanto as proteínas são divididas em aminoácidos e peptídeos para absorção e uso como fontes de proteína corporal. -/- O amido de cereais, por exemplo, é uma importante fonte de energia em bezerros mais velhos, mas esses animais, nas suas primeiras semanas de vida, não conseguem digerir o amido. -/- O abomaso não é ácido até que o bezerro tenha 1-2 dias de idade e isso apresenta vantagens e desvantagens. A principal vantagem é que as proteínas imunes no colostro não podem ser digeridas nesse compartimento estomacal, por isso são absorvidas na corrente sanguínea na mesma forma quando produzidas pela vaca. Isso garante o seu papel como anticorpos para proteger contra as doenças e infecções. A baixa acidez do conteúdo abomasal no bezerro recém-nascido constitui um risco potencial das bactérias (e provavelmente vírus) tomadas através da boca. Estes não serão mortos pela digestão ácida, sendo assim podem passar para os intestinos, onde podem fazer mal ao bezerro recém-nascido. -/- Todos os bezerros pegam bactérias nos primeiros dias de vida e isso é essencial para o desenvolvimento normal do rúmen (flora microbiana). No entanto, a primeira bactéria a colonizar o intestino também pode causar danos. Desde que o bezerro tenha bebido colostro, os anticorpos maternos podem controlar a propagação dessas bactérias mais nocivas. -/- O bezerro alimentado com leite deve, então, produzir uma digestão ácida no abomaso e uma digestão alcalina no duodeno. Isto é conseguido pela produção de eletrólitos na parede do intestino. -/- Bezerros que sofrem de escoriações devido a distúrbios nutricionais ou infecções bacterianas podem perder grandes quantidades de água e eletrólitos em suas fezes. Estes devem ser reabastecidos como parte do tratamento para as escoriações. -/- O colostro é o primeiro leite produzido por vacas recém-paridas. Além de fornecer nutrientes essenciais para a alimentação animal, fornece anticorpos maternos que permitem a transferência passiva de imunidade contra doenças. As recomendações para a alimentação com colostro serão abordadas brevemente em outro trabalho. -/- -/- 1.3 DESENVOLVIMENTO DO RÚMEN E O PROCESSO DE DESMAME -/- Quando os bezerros são desmamados, o custo da criação diminui acentuadamente. Os custos de alimentação são mais baixos, os insumos de trabalho são reduzidos e a incidência de problemas de saúde é menor. No sentido econômico, faz sentido desmamar os bezerros assim que for razoável. No entanto, o bezerro é forçado a sofrer várias mudanças dramáticas, a saber: -/-  A fonte primária de nutrientes muda de líquido para sólido. -/-  A quantidade de matéria seca que o bezerro recebe é reduzida. -/-  O bezerro deve adaptar-se de um tipo monogástrico a um ruminante de digestão, que inclui a fermentação de alimentos. -/-  Mudanças na habitação e no manejo muitas vezes ocorrem em torno do desmame, o que pode aumentar o estresse. -/- Ao nascer, o rúmen é uma parte pequena e estéril do intestino que, ao desmame deve se tornar o compartimento mais importante dos quatro estômagos. Deve aumentar em tamanho, atividade metabólica interna e fluxo sanguíneo externo. Os cinco requisitos para o desenvolvimento ruminal são: -/-  Estabelecimento de bactérias. -/-  Líquido. -/-  Saída de material (ação muscular). -/-  Capacidade absortiva do tecido. -/-  Substrato para permitir o crescimento bacteriano, tais como minerais reciclados, bem como nutrientes para alimentação. -/- Antes do consumo de alimentos sólidos, as bactérias existentes fermentam o cabelo ingerido, o estrato e o leite que flui do abomaso para o rúmen. A maior parte da água que entra no rúmen provém da água livre (água real não contida no leite ou na solução substituta do leite). O leite contornará o rúmen através do sulco esofágico, enquanto a água livre não. -/- O rúmen se desenvolve a partir de um órgão muito pequeno em bezerros recém-nascidos (1-2 L) para a parte mais importante do intestino (25-30 L) por 3 meses de idade. Ele pode aumentar muito rapidamente durante as primeiras semanas de vida, dado o manejo da alimentação direita. -/- O crescimento do rúmen ocorre apenas sob a influência dos produtos finais da digestão no mesmo, que resultam da fermentação de alimentos sólidos pelos micróbios presentes nesse compartimento. O desenvolvimento ocorre em grande parte através do crescimento das papilas ruminais (figura 5 e 6) na parede ruminal (estruturas semelhantes a folhas na superfície interna), que aumentam a área superficial do rúmen e, portanto, a sua capacidade de absorver estes produtos finais de digestão. Portanto, os concentrados favorecem melhor o desenvolvimento dessas papilas ruminais. Para tanto, é necessário, com um tempo, ir incrementando a dieta sólida gradativamente para que esses animais deixem de consumir o leite das vacas produtoras e possam alimentar-se de ração e pastagens, que é a finalidade da criação de bovinos, ou seja, criar animais com menor custo possível e engordá-los através de ração, mas principalmente de pastagens. -/- A capacidade do rúmen e a ingestão de alimentos sólidos estão intimamente relacionadas. O desenvolvimento do rúmen é muito lento em bezerros alimentados com grandes quantidades de leite. O leite satisfaz seus apetites para que eles não tenham fome suficiente para comer qualquer alimento sólido. Logo, é necessário diminuir paulatinamente o fornecedor do leite para esses animais, favorecendo a ingestão de alimentos sólidos e desenvolvendo o rúmen, estômago que digere as fibras das forragens e que os tona animais peculiares. -/- A ruminação pode ocorrer com cerca de 2 semanas de idade e é uma boa indicação de que o rúmen está se desenvolvendo. Alimentos sólidos, bem como a ruminação, estimulam a produção de saliva e isso fornece nutrientes como ureia e bicarbonato de sódio para produzir os substratos para o crescimento e desenvolvimento da flora bacteriana. -/- No desmame precoce, é importante limitar a quantidade de leite oferecida e a sua disponibilidade durante todo o dia. Também é essencial fornecer alimentos sólidos. Os grosseiros (de baixa ou alta qualidade) devem ser oferecidos em combinação com concentrados de alta qualidade. -/- O criador deve tomar cuidado com o fornecimento de alimentos como a ração farelada, uma vez que essa ração pode entrar pelas vias nasais e ocasionar complicações respiratórias; há alguns relatos de bezerros mortos após a ingestão de ração farelada, na autópsia de um dos casos foi diagnosticada uma morte por esses grãos farelados presentes no pulmão. Portanto, para evitar complicações o ideal é que se forneça uma ração denominada peletizada. -/- Os alimentos grosseiros (volumosos) estimulam o desenvolvimento do rúmen, enquanto os concentrados fornecem nutrientes para a alimentação animal que não são fornecidos pelas quantidades limitadas de leite oferecidas. Sem os concentrados, o crescimento dos bezerros é lento, mas o rúmen ainda se desenvolve, resultando em animais barrigudos. -/- A ureia fornece nitrogênio para os micróbios, enquanto o bicarbonato de sódio atua como um tampão ruminal, ajudando a manter um pH estável no conteúdo do rúmen. Isso é, particularmente, importante quando os bezerros comem grandes quantidades de grãos de cereais na vida adulta, pois os micróbios do rúmen podem produzir muito ácido lático durante a fermentação desse material. -/- Envenenamento por grãos ou acidose ocorre quando os níveis de ácido lático são excessivamente elevados e tornam-se tóxicos para os micróbios do rúmen e, eventualmente, para o animal. Assim como os produtos finais que são absorvidos através da parede do rúmen, a fermentação microbiana produz os gases dióxido de carbono e metano e estes são normalmente exalados. Quando algo impede a fuga destes gases do rúmen, o inchaço pode se manifestar em qualquer fase da vida, diz-se do animal estufado. -/- -/- 1.4 O PAPEL DA FORRAGEM NO PROCESSO DE DESMAME -/- Existem inúmeras controvérsias acerca do papel da forragem no processo de desmame. Pesquisas realizadas na década de 1980 indicaram claramente que a forragem era benéfica, enquanto pesquisas da década de 1990 descobriram que nem sempre era necessário o fornecimento da forragem para que os bezerros fossem desmamados e que não sofresse estresse e nem apresentasse baixa eficiência produtiva e reprodutiva no futuro. Na maioria das pesquisas anteriores, os bezerros eram desmamados com a oferta de concentrados moídos como pellets com ou sem a presença de feno longo ou palha. Porém, a inclusão de forragens na dieta melhorou a ingestão e o desempenho, além de permitir o desmame precoce. -/- Na pesquisa posterior, os bezerros geralmente alimentavam-se de concentrados grosseiramente moídos, além de alguns volumosos, enquanto alguns até incluíam volumosos picados finos na mistura (às vezes chamados de mistura muesli por apresentar o capim e a ração). Nesses estudos, verificou-se que a inclusão de feno ou palha adicional teve pouco efeito no desempenho pré-desmame. -/- Os sistemas de criação de bezerros australianos frequentemente diferem dos demais, especialmente em áreas de parto sazonais. Um número excessivo elevado de bezerros precisam ser criados de uma só vez para lhes fornecer, a todos, currais individuais durante todo o seu período de amamentação. Consequentemente, os bezerros são criados em grupos. Além disso, os ingredientes da maioria dos concentrados para esses animais são finamente moídos. Nessas situações, descobriu-se que a palha limpa é um alimento útil e que deve ser incluso no período pré-desmame. Alguns agricultores preferem feno de boa qualidade, porém estes agricultores geralmente têm bezerros em grupos muito pequenos, muitas vezes um ou dois, por isso possuem maior controle sobre a ingestão de forragem. -/- Figura 7: A alimentação volumosa de bezerros alimentados com leite é uma questão controversa. Imagem cedida pelo IPA -/- É difícil e, portanto, mais caro que os produtores de rações incorporem feno picado nas refeições dos bezerros. Os pellets são muito mais fáceis, pois eles vão fluir para silos. Por fim, os produtores de leite devem incluir o componente volumoso no regime alimentar pré-desmame. A pastagem não é a fonte ideal de forragem volumosa para os bezerros alimentados com leite, uma vez que possui muito pouca fibra e uma baixa densidade de energia alimentar. O seu elevado teor de água limita a sua capacidade de fornecer energia alimentar adequada aos animais em crescimento. Para ingerir a pastagem a capacidade ruminal deveria ser maior, bezerros jovens simplesmente não conseguem comer pasto suficiente, a menos que seja de alta em qualidade. -/- Os bezerros criados com leite e fornecimento gradual de concentrados apresentam uma boa função ruminal às 3 semanas de vida, além de possuírem uma suficiente capacidade ruminal para o desmame entre às 4-6 semanas de idade. No entanto, se a dieta for baseada em leite restrito e pastagem de alta qualidade, a capacidade do rúmen pode não ser suficiente para o desmame até às 8-10 semanas de vida. Mesmo assim, as taxas de crescimento seriam menores em bezerros desmamados com base alimentar somente à pasto, uma vez que a ingestão de energia é insuficiente devido às limitações físicas da capacidade ruminal. -/- Se a qualidade for muito boa e produza apetite, os bezerros preferem volumosos ao invés do concentrado, o que leva a uma ingestão reduzida de nutrientes durante alimentação, tendo como efeito um crescimento mais lento. Quando volumosos e concentrados fornecem apetite no animal, juntamente com o leite limitado, os bezerros podem comer cerca de 10% de palha e 90% de concentrados. Sem o volumoso e a ruminação resultante, o desenvolvimento do rúmen será mais lento devido à falta de saliva e produtos finais da digestão de fibras presentes na parede celular das forragens. -/- -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- -/- BEN ASHER, Aharon. Manual de cría de becerras. Zaragoza: Acribia, 1999. -/- BITTAR, Carla Maris Machado; PORTAL, Rafaela Nunes Sanchez; PEREIRA, Anna Carolina Fett da Cunha. Criação de bezerras leiteiras. Piracicaba: EDUSP, 2018. -/- BLUM, J. W. Nutritional physiology of neonatal calves. Journal of animal physiology and animal nutrition, v. 90, n. 1‐2, p. 1-11, 2006. -/- CAMPOS, OF de. Criação de bezerros até a desmama. Coronel Pacheco: EMBRAPA/CNPGL, 1985. -/- COELHO, S. G. Criação de bezerros. II Simpósio Mineiro de Buiatria, Anais., Belo Horizonte, 2005. -/- DAVIS, Carl L. et al. The development, nutrition, and management of the young calf. Iowa State University Press, 1998. -/- DE OLIVEIRA, Juliana Silva; DE MOURA ZANINE, Anderson; SANTOS, Edson Mauro. Fisiologia, manejo e alimentação de bezerros de corte. Arquivos de Ciências Veterinárias e Zoologia da UNIPAR, v. 10, n. 1, 2007. -/- DRACKLEY, James K. Calf nutrition from birth to breeding. Veterinary Clinics of North America: Food Animal Practice, v. 24, n. 1, p. 55-86, 2008. -/- FERREIRA, Lucas Silveira et al. Desempenho animal e desenvolvimento do rúmen de bezerros leiteiros aleitados com leite integral ou sucedâneo. Boletim de Indústria Animal, v. 65, n. 4, p. 337-345, 2008. -/- GUILLOTEAU, P.; ZABIELSKI, R.; BLUM, J. W. Gastrointestinal tract and digestion in the young ruminant: ontogenesis, adaptations, consequences and manipulations. J Physiol Pharmacol, v. 60, n. Suppl 1, p. 37-46, 2009. -/- HUBER, J. T. Development of the digestive and metabolic apparatus of the calf. Journal of Dairy Science, v. 52, n. 8, p. 1303-1315, 1969. -/- LONGENBACH, J. I.; HEINRICHS, Arlyn Judson. A review of the importance and physiological role of curd formation in the abomasum of young calves. Animal feed science and technology, v. 73, n. 1-2, p. 85-97, 1998. -/- LOPES, Marcos Aurélio; VIEIRA, P. de F. Criação de bezerros leiteiros. Jaboticabal: Funep, 1998. -/- LUCCI, Carlos de Sousa. Bovinos leiteiros jovens: nutrição, manejo, doenças. São Paulo: Nobel, 1989. -/- ROY, James Henry Barstow et al. The calf. Boston: Butterworths., 1980. -/- SAVAGE, E. S.; MCCAY, C. M. The nutrition of calves; A review. Journal of Dairy Science, v. 25, n. 7, p. 595-650, 1942. -/- THIVEND, P.; TOULLEC, R.; GUILLOTEAU, P. Digestive adaptation in the preruminant. In: Digestive physiology and metabolism in ruminants. Springer, Dordrecht, 1980. p. 561-585. (shrink)

That about sums up what is wrong with Clark's view.

Philosophical discussions of species have focused on multicellular, sexual animals and have often neglected to consider unicellular organisms like bacteria. This article begins to fill this gap by considering what species concepts, if any, apply neatly to the bacterial world. First, I argue that the biological species concept cannot be applied to bacteria because of the variable rates of genetic transfer between populations, depending in part on which gene type is prioritized. Second, I present a critique of phylogenetic bacterial species, (...) arguing that phylogenetic bacterial classification requires a questionable metaphysical commitment to the existence of essential genes. I conclude by considering how microbiologists have dealt with these biological complexities by using more pragmatic and not exclusively evolutionary accounts of species. I argue that this pragmatism is not borne of laziness but rather of the substantial conceptual problems in classifying bacteria based on any evolutionary standard. (shrink)

This paper presents an attempt to integrate theories of causal processes—of the kind developed by Wesley Salmon and Phil Dowe—into a theory of causal models using Bayesian networks. We suggest that arcs in causal models must correspond to possible causal processes. Moreover, we suggest that when processes are rendered physically impossible by what occurs on distinct paths, the original model must be restricted by removing the relevant arc. These two techniques suffice to explain cases of late preëmption and other cases (...) that have proved problematic for causal models. (shrink)

At least since Aristotle's famous discussion of the sea-battle tomorrow in On Interpretation 9, philosophers have been fascinated by a rich set of interconnecte.

Yuri Matiyasevich's theorem states that the set of all Diophantine equations which have a solution in non-negative integers is not recursive. Craig Smoryński's theorem states that the set of all Diophantine equations which have at most finitely many solutions in non-negative integers is not recursively enumerable. Let R be a subring of Q with or without 1. By H_{10}(R), we denote the problem of whether there exists an algorithm which for any given Diophantine equation with integer coefficients, can decide whether (...) or not the equation has a solution in R. We prove that a positive solution to H_{10}(R) implies that the set of all Diophantine equations with a finite number of solutions in R is recursively enumerable. We show the converse implication for every infinite set R \subseteq Q such that there exist computable functions \tau_1,\tau_2:N \to Z which satisfy (\forall n \in N \tau_2(n) \neq 0) \wedge ({\frac{\tau_1(n)}{\tau_2(n)}: n \in N}=R). This implication for R=N guarantees that Smoryński's theorem follows from Matiyasevich's theorem. Harvey Friedman conjectures that the set of all polynomials of several variables with integer coefficients that have a rational solution is not recursive. Harvey Friedman conjectures that the set of all polynomials of several variables with integer coefficients that have only finitely many rational solutions is not recursively enumerable. These conjectures are equivalent by our results for R=Q. (shrink)

Looking at the recent spate of claims about “fake news” which appear to be a new feature of political discourse, I argue that fake news presents an interesting problem in epistemology. Te phenomena of fake news trades upon tolerating a certain indiference towards truth, which is sometimes expressed insincerely by political actors. Tis indiference and insincerity, I argue, has been allowed to fourish due to the way in which we have set the terms of the “public” epistemology that maintains what (...) is considered “rational” public discourse. I argue one potential salve to the problem of fake news is to challenge this public epistemology by injecting a certain ethical consideration back into the discourse. (shrink)

1. Do models formulated in programming languages use explicit rules where connectionist models do not? 2. Are rules as found in programming languages hard, precise, and exceptionless, where connectionist rules are not? 3. Do connectionist models use rules operating on distributed representations where models formulated in programming languages do not? 4. Do connectionist models fail to use structure sensitive rules of the sort found in "classical" computer architectures? In this chapter we argue that the answer to each of these questions (...) is negative. (shrink)

Various philosophers have wanted to move from a (P.F.) “Strawsonian” understanding of the “practices of moral responsibility” to a non-skeptical result. I focus on a strategy moving from a “response-dependent” theory of responsibility. I aim to show that a key analogy associated with this strategy fails to support a compatibilist result. It seems clear that nothing could show that nothing we have been laughing at has really been funny. If “the funny” is similar to “the blameworthy”, then perhaps it would (...) follow that nothing could show that no one we have ever blamed has really been blameworthy. The comparison is interesting, but inconclusive: even if we grant that these properties are normatively similar, the latter has substantive empirical presuppositions, whereas the former does not. One important upshot: even if the standards operative in our practices cannot be mistaken, it could nevertheless be that no one has ever met these standards Ruling out this possibility seemingly requires re-engaging in all of the so-called "metaphysical" debates Strawsonians are keen to avoid. (shrink)

Loneliness in medicine is a serious problem not just for patients, for whom illness is intrinsically isolating, but also for physicians in the contemporary condition of medicine. We explore this problem by investigating the ideal physician-patient relationship, whose analogy with friendship has held enduring normative appeal. Drawing from Talbot Brewer and Nir Ben-Moshe, we argue that this appeal lies in a dynamic form of companionship incompatible with static models of friendship-like physician-patient relationships: a mutual refinement of embodied virtue that draws (...) both persons together. The ideal physician-patient relationship has a dialectical character that fosters each member's improvement of phenomenologically recognizing and embodying moral virtues. A key component of this dynamic is a commitment to the common goal of the patient's health, realized through joint interactivities and conversations over time. The physician's presence to the patient's suffering—understood best as an alienating phenomenological condition for the patient—orients and discloses possibilities for virtuous caregiving by structuring the meanings of the goals, conversations, and joint narrative constitutive of their relationship. Presence to suffering, paradoxically, is perhaps an important prerequisite for this dynamic partnership. These activities dialectically build an interpretive horizon of understanding through which moral goods and character refinement—in and for the other—may become revealed for both persons in their shared being-in-the-world. This analysis of suffering, mood, and revealing of (possible) moral goods has implications for addressing the modern problem of loneliness for patients and physicians, who are increasingly inhibited from building flourishing relationships with each other. (shrink)

The paper is written in response to those who fail to recognize the relation between a patient's mental competency and her state of pain. Some clinicians claim that a proper diagnosis can only be made in the absent of analgesia. Rather, the patient's state of pain directly affects her mental competency and thus her ability to give valid consent. Clinicians should rethink their approach to diagnosis when the patient is in pain.

Belief in conspiracy theories is typically considered irrational, and as a consequence of this, conspiracy theorists––those who dare believe some conspiracy theory––have been charged with a variety of epistemic or psychological failings. Yet recent philosophical work has challenged the view that belief in conspiracy theories should be considered as typically irrational. By performing an intra-group analysis of those people we call “conspiracy theorists”, we find that the problematic traits commonly ascribed to the general group of conspiracy theorists turn out to (...) be merely a set of stereotypical behaviours and thought patterns associated with a purported subset of that group. If we understand that the supposed prob- lem of belief in conspiracy theories is centred on the beliefs of this purported sub- set––the conspiracists––then we can reconcile the recent philosophical contribu- tions to the wider academic debate on the rationality of belief in conspiracy theories. (shrink)

A striking feature of post-modernism is its distrust of the subject. If the modern period, beginning with Descartes, sought in the subject a source of certainty, an Archimedian point from which all else could be derived, post- modernism has taken the opposite tack. Rather than taking the self as a foundation, it has seen it as founded, as dependent on the accidents which situate consciousness in the world. The same holds for the unity of the subject. Modernity, in its search (...) for a single foundation, held the subject to be an indissoluble unity. Post-modernism’s position, by contrast, is announced by Nietzsche: “The assumption of one single subject is perhaps unnecessary; perhaps it is just as permissible to assume a multiplicity of subjects, whose interaction and struggle is the basis of our thought and our consciousness in general? ...My hypotheses: The subject as multiplicity.” Given this, there is a natural correspondence between the success of post- modernism and the current interest in multiple personality disorder. In the latter, we actually have the experience of a “multiplicity of subjects” in their interaction and struggle. The subject stands there before us “as multiplicity.” It gives us a concrete case, one which raises some of the pressing questions associated with the post-modern denial of the subject. Confronting it, we ask: how real are the personalities composing the multiplicity of this disordered self? What, in fact, does this multiplicity tell us about the self? about its genesis and status? What does it reveal about “our thought and consciousness in general”? I plan, in the short compass of this paper, to sketch some answers to these questions. §1. A brief description of MPD. The American Psychiatric Association gives two criteria for (MPD) multiple personality disorder. First, and most obviously, there is “the existence within the person of two or more distinct personalities or personality states (each with its own relatively enduring pattern. (shrink)

These are my materials (a short precis, and replies to John MacFarlane, Mitchell Green, Ryan Wasserman, and Anthony Bigg and Kristie Miller) for a symposium on my book, _The Open Future: Why Future Contingents are All False_ (OUP, 2021) in *Analytic Philosophy*. [The contribution from MacFarlane is available on his website, those from Wasserman and Green are on their Academia profiles, and the contribution from Bigg and Miller is on Miller's PhilPapers profile.].

Judging the warrant of conspiracy theories can be difficult, and often we rely upon what the experts tell us when it comes to assessing whether particular conspiracy theories ought to be believed. However, whereas there are recognised experts in the sciences, I argue that only are is no such associated expertise when it comes to the things we call `conspiracy theories,' but that the conspiracy theorist has good reason to be suspicious of the role of expert endorsements when it comes (...) to conspiracy theories and their rivals. The kind of expertise, then, we might associate with conspiracy theories is largely improvised—in that it lacks institutional features—and, I argue, ideally the product of a community of inquiry. (shrink)

The concept of instantiation is realized differently across a variety of metaphysical theories. A certain realization of the concept in a given theory depends on what roles are specified and associated with the concept and its corresponding term as well as what entities are suited to fill those roles. In this paper, the classic realization of the concept of instantiation in a one-category ontology of abstract particulars or tropes is articulated in a novel way and defended against unaddressed objections.

This book launches a sustained defense of a radical interpretation of the doctrine of the open future. Patrick Todd argues that all claims about undetermined aspects of the future are simply false.

Th e present article reports a series of experiments designed to extend the empirical investigation of folk metaethical intuitions by examining how different kinds of ethical disagreement can impact attributions of objectivity to ethical claims.

Inspired by Peter van Inwagen’s “simulacra model” of the resurrection, I investigate whether it could be reasonable to adopt an analogous approach to the problem of evil. Empirically Skeptical Theism, as I call it, is the hypothesis that God shields our lives from irredeemable evils surreptitiously (just as van Inwagen proposes that God shields our bodies from destruction surreptitiously). I argue that EST compares favorably with traditional skeptical theism and with eschatological theodicies, and that EST does not have the negative (...) moral consequences we might suppose. (shrink)

The aim of this paper is to provide a conceptual framework that will help in understanding and evaluating, along social and ethical lines, the issue of killing day-old male chicks and two alternative directions of responsible innovations to solve this issue. The following research questions are addressed: Why is the killing of day-old chicks morally problematic? Are the proposed alternatives morally sound? To what extent do the alternatives lead to responsible innovation? The conceptual framework demonstrates clearly that there is a (...) moral “lock-in”, and why the killing of day-old chicks is indeed an issue. Furthermore, it is shown that both alternative directions address some important objections with regard to the killing of day-old chicks, but that they also raise new dilemmas. It also becomes clear that the framework enables and secures anticipation, reflection, deliberation with and responsiveness to stakeholders, the four dimensions of responsible innovation, in a structured way. (shrink)

This paper critically examines color relationalism and color relativism, two theories of color that are allegedly supported by variation in normal human color vision. We mostly discuss color relationalism, defended at length in Jonathan Cohen's The Red and the Real, and argue that the theory has insuperable problems.