This paper takes part in the methodological debate concerning the nature and the justification of hypotheses about computational systems in software engineering by providing an epistemological analysis of Software Testing, the practice of observing the programs’ executions to examine whether they fulfil software requirements. Property specifications articulating such requirements are shown to involve falsifiable hypotheses about software systems that are evaluated by means of tests which are likely to falsify those hypotheses. Software Reliability metrics, used to measure the growth of (...) probability that given failures will occur at specified times as new executions are observed, is shown to involve a Bayesian confirmation of falsifiable hypotheses on programs. Coverage criteria, used to select those input values with which the system under test is to be launched, are understood as theory-laden principles guiding software tests, here compared to scientific experiments. Redundant computations, fault seeding models and formal methods used in software engineering to evaluate test results are taken to be instantiations of some epistemological strategies used in scientific experiments to distinguish between valid and non-valid experimental outcomes. The final part of the paper explores the problem, advanced in the context of the philosophy of technology, of defining the epistemological status of software engineering by conceiving it as a scientifically attested technology. (shrink)

A piece of folklore enjoys some currency among philosophical Bayesians, according to which Bayesian agents that, intuitively speaking, spread their credence over the entire space of available hypotheses are certain to converge to the truth. The goals of the present discussion are to show that kernel of truth in this folklore is in some ways fairly small and to argue that Bayesian convergence-to-the-truth results are a liability for Bayesianism as an account of rationality, since they render a certain sort of (...) arrogance rationally mandatory. (shrink)

Amalgamating evidence of different kinds for the same hypothesis into an overall confirmation is analogous, I argue, to amalgamating individuals’ preferences into a group preference. The latter faces well-known impossibility theorems, most famously “Arrow’s Theorem”. Once the analogy between amalgamating evidence and amalgamating preferences is tight, it is obvious that amalgamating evidence might face a theorem similar to Arrow’s. I prove that this is so, and end by discussing the plausibility of the axioms required for the theorem.

According to the demand of the Hypothetico-Deductive (H-D) method, a theory is confirmed when the prediction-observation (p-o) gap is small and disconfirmed when the gap is large. A major goal of this paper is to introduce a research domain for which this demand does not hold. In contrast to the H-D method's demand, this research, called the Catch model for reconstructing a face previously seen from memory, requires an increase, within limits, in the p-o gap. The Catch model research substantiates (...) theoretically and empirically a new proposed method that I call the "Deductive-Reconstruction" (D-R) method. This method provides essential conditions whose fulfillment guarantees successful reconstruction of past events (a face previously seen) from memory. It is argued that the D-R method fits the area of research of reconstructing past events from memory better than the H-D method. Application of the H-D method to the Catch model's research domain leads to an internal contradiction and failure to reconstruct past events (a face previously seen) from memory. Finally, the nature of the D-R method along with the Catch model is discussed from three points of view: confirmation, explanation, and generality. (shrink)

Karl Popper is famous for having proposed that science advances by a process of conjecture and refutation. He is also famous for defending the open society against what he saw as its arch enemies – Plato and Marx. Popper’s contributions to thought are of profound importance, but they are not the last word on the subject. They need to be improved. My concern in this book is to spell out what is of greatest importance in Popper’s work, what its failings (...) are, how it needs to be improved to overcome these failings, and what implications emerge as a result. The book consists of a collection of essays which dramatically develop Karl Popper’s views about natural and social science, and how we should go about trying to solve social problems. Criticism of Popper’s falsificationist philosophy of natural science leads to a conception of science that I call aim-oriented empiricism. This makes explicit metaphysical theses concerning the comprehensibility and knowability of the universe that are an implicit part of scientific knowledge – implicit in the way science excludes all theories that are not explanatory, even those that are more successful empirically than accepted theories. Aim-oriented empiricism has major implications, not just for the academic discipline of philosophy of science, but for science itself. Popper generalized his philosophy of science of falsificationism to arrive at a new conception of rationality – critical rationalism – the key methodological idea of Popper’s profound critical exploration of political and social issues in his The Open Society and Its Enemies, and The Poverty of Historicism. This path of Popper, from scientific method to rationality and social and political issues is followed here, but the starting point is aim-oriented empiricism rather than falsificationism. Aim-oriented empiricism is generalized to form a conception of rationality I call aim-oriented rationalism. This has far-reaching implications for political and social issues, for the nature of social inquiry and the humanities, and indeed for academic inquiry as a whole. The strategies for tackling social problems that arise from aim-oriented rationalism improve on Popper’s recommended strategies of piecemeal social engineering and critical rationalism, associated with Popper’s conception of the open society. This book thus sets out to develop Popper’s philosophy in new and fruitful directions. The theme of the book, in short, is to discover what can be learned from scientific progress about how to achieve social progress towards a better world. (shrink)

Epistemology is the study of knowledge and justified belief. Belief is thus central to epistemology. It comes in a qualitative form, as when Sophia believes that Vienna is the capital of Austria, and a quantitative form, as when Sophia's degree of belief that Vienna is the capital of Austria is at least twice her degree of belief that tomorrow it will be sunny in Vienna. Formal epistemology, as opposed to mainstream epistemology (Hendricks 2006), is epistemology done in a formal way, (...) that is, by employing tools from logic and mathematics. The goal of this entry is to give the reader an overview of the formal tools available to epistemologists for the representation of belief. A particular focus will be the relation between formal representations of qualitative belief and formal representations of quantitative degrees of belief. (shrink)

What attitude should we take toward a scientific theory when it competes with other scientific theories? This question elicited different answers from instrumentalists, logical positivists, constructive empiricists, scientific realists, holists, theory-ladenists, antidivisionists, falsificationists, and anarchists in the philosophy of science literature. I will summarize the diverse philosophical responses to the problem of underdetermination, and argue that there are different kinds of underdetermination, and that they should be kept apart from each other because they call for different responses.

Showcasing original arguments for well-defined positions, as well as clear and concise statements of sophisticated philosophical views, this volume is an ...

This book argues for the need to put into practice a profound and comprehensive intellectual revolution, affecting to a greater or lesser extent all branches of scientific and technological research, scholarship and education. This intellectual revolution differs, however, from the now familiar kind of scientific revolution described by Kuhn. It does not primarily involve a radical change in what we take to be knowledge about some aspect of the world, a change of paradigm. Rather it involves a radical change in (...) the fundamental, overall intellectual aims and methods of inquiry. At present inquiry is devoted to the enhancement of knowledge. This needs to be transformed into a kind of rational inquiry having as its basic aim to enhance personal and social wisdom. This new kind of inquiry gives intellectual priority to the personal and social problems we encounter in our lives as we strive to realize what is desirable and of value – problems of knowledge and technology being intellectually subordinate and secondary. For this new kind of inquiry, it is what we do and what we are that ultimately matters: our knowledge is but an aspect of our life and being. (shrink)

How to regard the weight we give to a proposition on the grounds of its being endorsed by an authority? I examine this question as it is raised within the epistemology of science, and I argue that “authority-based weight” should receive special handling, for the following reason. Our assessments of other scientists’ competence or authority are nearly always provisional, in the sense that to save time and money, they are not made nearly as carefully as they could be---indeed, they are (...) typically made on the basis of only a small portion of the available evidence. Consequently, we need to represent the authority-based elements of our epistemic attitudes in such a way as to allow the later revision of those elements, in case we decide in the light of new priorities that a more conscientious assessment is warranted. I look to the literature in confirmation theory, statistics, and economics for a semiformal model of this revision process, and make a particular proposal of my own. The discussion also casts some light on the question of why certain aspects of science’s epistemic state are not made public. (shrink)

The ontology of decision theory has been subject to considerable debate in the past, and discussion of just how we ought to view decision problems has revealed more than one interesting problem, as well as suggested some novel modifications of classical decision theory. In this paper it will be argued that Bayesian, or evidential, decision-theoretic characterizations of decision situations fail to adequately account for knowledge concerning the causal connections between acts, states, and outcomes in decision situations, and so they are (...) incomplete. Second, it will be argues that when we attempt to incorporate the knowledge of such causal connections into Bayesian decision theory, a substantial technical problem arises for which there is no currently available solution that does not suffer from some damning objection or other. From a broader perspective, this then throws into question the use of decision theory as a model of human or machine planning. (shrink)

Bayesian confirmation theory—abbreviated to in these notes—is the predominant approach to confirmation in late twentieth century philosophy of science. It has many critics, but no rival theory can claim anything like the same following. The popularity of the Bayesian approach is due to its flexibility, its apparently effortless handling of various technical problems, the existence of various a priori arguments for its validity, and its injection of subjective and contextual elements into the process of confirmation in just the places where (...) critics of earlier approaches had come to think that subjectivity and sensitivity to context were necessary. (shrink)

The posthumous publication, in 1763, of Thomas Bayes’ “Essay Towards Solving a Problem in the Doctrine of Chances” inaugurated a revolution in the understanding of the confirmation of scientific hypotheses—two hundred years later. Such a long period of neglect, followed by such a sweeping revival, ensured that it was the inhabitants of the latter half of the twentieth century above all who determined what it was to take a “Bayesian approach” to scientific reasoning.

The use of the material theory of induction to vindicate a scientist's claims of evidential warrant is illustrated with the cases of Einstein's thermodynamic argument for light quanta of 1905 and his recovery of the anomalous motion of Mercury from general relativity in 1915. In a survey of other accounts of inductive inference applied to these examples, I show that, if it is to succeed, each account must presume the same material facts as the material theory and, in addition, some (...) general principle of inductive inference not invoked by the material theory. Hence these principles are superfluous and the material theory superior in being more parsimonious. (shrink)

My purpose in this chapter is to survey some of the principal approaches to inductive inference in the philosophy of science literature. My first concern will be the general principles that underlie the many accounts of induction in this literature. When these accounts are considered in isolation, as is more commonly the case, it is easy to overlook that virtually all accounts depend on one of very few basic principles and that the proliferation of accounts can be understood as efforts (...) to ameliorate the weaknesses of those few principles. In the earlier sections, I will lay out three inductive principles and the families of accounts of induction they engender. In later sections I will review standard problems in the philosophical literature that have supported some pessimism about induction and suggest that their import has been greatly overrated. In the final sections I will return to the proliferation of accounts of induction that frustrates efforts at a final codification. I will suggest that this proliferation appears troublesome only as long as we expect inductive inference to be subsumed under a single formal theory. If we adopt a material theory of induction in which individual inductions are licensed by particular facts that prevail only in local domains, then the proliferation is expected and not problematic. (shrink)

It is argued that a subject's evidence consists of all and only the propositions that the subject knows.

Much of scientific inference involves fitting numerical data with a curve, or functional relation. The received view is that the fittest curve is the curve which best balances the conflicting demands of simplicity and accuracy, where simplicity is measured by the number ofparameters in the curve. The problem with this view is that there is no commonly accepted justification for desiring simplicity. This paper presents a measure of the stability of equations. It is argued that the fittest curve is the (...) curve which best balances stability and accuracy. The received view is defended with a proof that simplicity corresponds to stability, for linear regression equations. 1This paper is based on part of my doctoral dissertation. My thanks go to my thesis supervisor Professor Alasdair Urquhart for his encouragement, constructive criticism, and for directing me to several relevant articles: to my advisor Professor Ian Hacking for reminding me to concentrate on results that might have some application in the real world; and to my friend Wendy Brandts for sharing her ideas on a closely related problem. My thanks also to an anonymous referee of The British Journal of the Philosophy of Science for several helpful comments, to my friends and family for unfailing support, and to the Social Sciences and Humanities Research Council (awards 452-86-5885 and 453-87-0513) and the University of Toronto for financial assistance. (shrink)

Following Nancy Cartwright and others, I suggest that most (if not all) theories incorporate, or depend on, one or more idealizing assumptions. I then argue that such theories ought to be regimented as counterfactuals, the antecedents of which are simplifying assumptions. If this account of the logic form of theories is granted, then a serious problem arises for Bayesians concerning the prior probabilities of theories that have counterfactual form. If no such probabilities can be assigned, the the posterior probabilities will (...) be undefined, as the latter are defined in terms of the former. I argue here that the most plausible attempts to address the problem of probabilities of conditionals fail to help Bayesians, and, hence, that Bayesians are faced with a new problem. In so far as these proposed solutions fail, I argue that Bayesians must give up Bayesianism or accept the counterintuitive view that no theories that incorporate any idealizations have ever really been confirmed to any extent whatsoever. Moreover, as it appears that the latter horn of this dilemma is highly implausible, we are left with the conclusion that Bayesianism should be rejected, at least as it stands. (shrink)

On analogy with testimony, I define a notion of a scientific theory’s lacking or having candor, in a testing situation, according to whether the theory under test is probabilistically relevant to the processes in the test procedures, and thereby to the reliability of test outcomes. I argue that this property identifies what is distinctive about those theories that Karl Popper denounced as exhibiting “reinforced dogmatism” through their self-protective behavior (e.g., psychoanalysis, Hegelianism, Marxism). I explore whether lack of candor interferes with (...) the testing of theories, and conclude that (1) our default attitude toward theories that lack candor in a given test should be suspicion, but (2) the circumstance that a theory lacks candor in a testing situation does not preclude obtaining independent evidence for the auxiliary assumptions to which the theory is probabilistically relevant, and thereby eliminating the problem that lack of candor creates. Thus, Popper was right to think that lack of candor is a bad thing, but wrong to conclude that candor is a criterion of the scientificity of a theory. Seeing this requires recognition of some differences between intuitive relevance and probabilistic relevance, and proper appreciation of the notion of screening off and of the fact that probabilistic relevance is not transitive. (shrink)

With the notable exception of David Lewis, most of those writing on the Sleeping Beauty problem have argued that 1/3 is the correct answer. Terence Horgan has provided the clearest account of why, contrary to Lewis, Beauty has evidence against the proposition that the coin comes up heads when she awakens on Monday. In this paper, I argue that Horgan’s proposal fails because it neglects important facts about epistemic probability.

It is well known that the process of scientific inquiry, according to Peirce, is drivenby three types of inference, namely abduction, deduction, and induction. What isbehind these labels is, however, not so clear. In particular, the common identificationof abduction with Inference to the Best Explanation (IBE) begs the question,since IBE appears to be covered by Peirce's concept of induction, not that of abduction.Consequently, abduction ought to be distinguished from IBE, at least on Peirce's account. The main aim of the paper, (...) however, is to show that this distinction is most relevant with respect to current problems in philosophy of science and epistemology (like attempts to supply suitable notions of realism and truth as well as related concepts like coherence and unification). In particular, I also try to show that (and in what way) Peirce's inferential triad can function as a method that ensures both coherence and correspondence. It is in this respect that his careful distinction between abduction and induction (or IBE) ought to be heeded. (shrink)

This paper offers an answer to Glymour's ‘old evidence’ problem for Bayesian confirmation theory, and assesses some of the objections, in particular those recently aired by Chihara, that have been brought against that answer. The paper argues that these objections are easily dissolved, and goes on to show how the answer it proposes yields an intuitively satisfactory analysis of a problem recently discussed by Maher. Garber's, Niiniluoto's and others’ quite different answer to Glymour's problem is considered and rejected, and the (...) paper concludes with some brief reflections on the prediction/accommodation issue. (shrink)

I propose an approach to naturalized philosophy of science that takes the social nature of scientific practice seriously. I criticize several prominent naturalistic approaches for adopting "cognitive individualism", which limits the study of science to an examination of the internal psychological mechanisms of scientists. I argue that this limits the explanatory capacity of these approaches. I then propose a three-level model of the social nature of scientific practice, and use the model to defend the claim that scientific knowledge is socially (...) produced. (shrink)

In ethical discourse, it is common practice to distinguish between normative commitments and descriptive commitments. Normative commitments reflect what a person ought to be committed to, whereas descriptive commitments reflect what a person actually is committed to. While the normative/descriptive distinction is widely accepted as a way of talking about ethical commitments, philosophers have missed this distinction in discussing ontological commitments. In this paper, I distinguish between descriptive ontological commitments and normative ontological commitments and discuss several significant benefits of recognizing (...) this distinction. I argue that just as the normative/descriptive distinction is important for fruitful ethical discourse, so too is it important for fruitful discourse concerning our ontological commitments. And, it constitutes a significant step towards resolving some prominent debates concerning our ontological commitments. (shrink)

The role that need plays in dealing with problems of distributive justice is examined in a series of vignette studies. Among other things, it becomes clear that impartial observers make gradual assessments of justice that depend on the extent to which the observed individuals are endowed with a good. If it is known how high their need for that good is, the assessments are made relative to this reference point. In addition, impartial decision-makers make hypothetical distribution decisions that take into (...) account need, productivity, and accountability. The need of individuals is partially compensated even if they have contributed less to the available amount than they themselves require. However, the willingness to do so decreases if they are accountable for needing more than others or for having contributed less than others. Lastly, both impartial observers and impartial decision-makers distinguish between different types of needs, the fulfillment of which is given different levels of importance. (shrink)

Reasoning from inconclusive evidence, or ‘induction’, is central to science and any applications we make of it. For that reason alone it demands the attention of philosophers of science. This Element explores the prospects of using probability theory to provide an inductive logic, a framework for representing evidential support. Constraints on the ideal evaluation of hypotheses suggest that overall support for a hypothesis is represented by its probability in light of the total evidence, and incremental support, or confirmation, indicated by (...) an increased probability given the evidence than otherwise. This proposal is shown to have the capacity to reconstruct many canons of the scientific method and inductive inference. Along the way, significant objections are discussed, such as the challenge from inductive scepticism and the objection that the probabilistic approach makes evidential support arbitrary. (shrink)

Awareness growth—coming to entertain propositions of which one was previously unaware—is a crucial aspect of epistemic thriving. And yet, it is widely believed that orthodox Bayesianism cannot accommodate this phenomenon, since that would require employing supposedly defective catch-all propositions. Orthodox Bayesianism, it is concluded, must be amended. In this paper, I show that this argument fails, and that, on the contrary, the orthodox version of Bayesianism is particularly well-suited to accommodate awareness growth. For it entails what I call the refinement (...) view, which allows us to capture that awareness growth consists in the increase of one’s capacity of discernment. (shrink)

We argue that a modified version of Mill’s method of agreement can strongly confirm causal generalizations. This mode of causal inference implicates the explanatory virtues of mechanism, analogy, consilience, and simplicity, and we identify it as a species of Inference to the Best Explanation (IBE). Since rational causal inference provides normative guidance, IBE is not a heuristic for Bayesian rationality. We give it an objective Bayesian formalization, one that has no need of principles of indifference and yields responses to the (...) Voltaire objection, van Fraassen’s Bad Lot objection, and John Norton’s recent objection to IBE. (shrink)

Tacking by conjunction is a well-known problem for Bayesian confirmation theory. In the first section, disadvantages of existing Bayesian solution proposals to this problem are pointed out and an alternative solution proposal is presented: that of genuine confirmation. In the second section, the notion of GC is briefly recapitulated and three versions of GC are distinguished: full GC, partial GC and quantitative GC. In the third section, the application of partial GC to pure post-facto speculations is explained. In the fourth (...) section it is demonstrated that full GC is a necessary condition for Bayesian convergence to certainty based on the accumulation of conditionally independent pieces of evidence. It is found that whenever a hypothesis is equivalent to a disjunction of more fine-grained hypotheses conveying different probabilities to the evidence, then conditional independence of the evidence fails. This failure occurs typically for unspecific negations of hypotheses. A refined version of the convergence to certainty theorem that overcomes this difficulty is developed in the final section. (shrink)

The aim of this thesis is to improve our understanding of how to assess and communicate uncertainty in areas of research deeply afflicted by it, the assessment and communication of which are made more fraught still by the studies’ immediate policy implications. The IPCC is my case study throughout the thesis, which consists of three parts. In Part 1, I offer a thorough diagnosis of conceptual problems faced by the IPCC uncertainty framework. The main problem I discuss is the persistent (...) ambiguity surrounding the concepts of ‘confidence’ and ‘likelihood’; I argue that the lack of a conceptually valid interpretation of these concepts compatible with the IPCC uncertainty guide’s recommendations has worrying implications for both the IPCC authors’ treatment of uncertainties and the interpretability of the information provided in the AR5. Finally, I show that an understanding of the reasons behind the IPCC’s decision to include two uncertainty scales can offer insights into the nature of this problem. In Part 2, I review what philosophers have said about model-based robustness analysis. I assess several arguments that have been offered for its epistemic import and relate this discussion to the context of climate model ensembles. I also discuss various measures of independence in the climate literature, and assess the extent to which these measures can help evaluate the epistemic import of model robustness. In Part 3, I explore the notion of the ‘weight of evidence’ typically associated with Keynes. I argue that the Bayesian is bound to struggle with this notion, and draw some lessons from this fact. Finally, I critically assess some recent proposals for a new IPCC uncertainty framework that significantly depart from the current one. (shrink)

This paper proposes a framework for representing in Bayesian terms the idea that analogical arguments of various degrees of strength may provide inductive support to yet untested scientific hypotheses. On this account, contextual information plays a crucial role in determining whether, and to what extent, a given similarity or dissimilarity between source and target may confirm an empirical hypothesis over a rival one. In addition to showing confirmation by analogy compatible with the adoption of a Bayesian standpoint, the proposal outlined (...) in this paper reveals a close agreement between the fulfillment of Hesse’s (Models and analogies in science, University of Notre Dame Press, 1963) criteria for analogical arguments capable of inductive support and the attribution of confirmatory power by the lights of Bayesian confirmation theory. In this sense, the Bayesian representation not only enriches a framework, Hesse’s, of enduring relevance for understanding scientific activity, but may offer something akin to a proof of concept of it. (shrink)

Bayesian confirmation theory is our best formal framework for describing inductive reasoning. The problem of old evidence is a particularly difficult one for confirmation theory, because it suggests that this framework fails to account for central and important cases of inductive reasoning and scientific inference. I show that we can appeal to the fragmentation of doxastic states to solve this problem for confirmation theory. This fragmentation solution is independently well-motivated because of the success of fragmentation in solving other problems. I (...) also argue that the fragmentation solution is preferable to other solutions to the problem of old evidence. These other solutions are already committed to something like fragmentation, but suffer from difficulties due to their additional commitments. If these arguments are successful, Bayesian confirmation theory is saved from the problem of old evidence, and the argument for fragmentation is bolstered by its ability to solve yet another problem. (shrink)

"Partial realism" is a common position in the contemporary philosophy of science literature. It states that the "essential" elements of empirically successful scientific theories accurately represent corresponding features the world. This thesis makes several novel contributions related to this position. Firstly, it offers a new definition of the concept of “empirical success”, representing a principled merger between the use-novelty and unification accounts. Secondly, it provides a comparative critical analysis of various accounts of which elements are "essential" to the success of (...) a theory, including structural realism and the divide et impera strategy. A novel account of essentialness, entitled the “empirically successful sub-theory "account", is defended. Thirdly, it is argued that the realism/anti-realism debate should put to the side metaphysical questions and focus instead on partial realism's commitment to the continuity of science. Because this commitment lacks metaphysical implications, it is referred to as "deflationary realism". Anti-realists cannot reject deflationary realism as a matter of a priori principle; its overall viability can therefore only be assessed by a careful examination of the history of science. Finally, another consequence of partial realism, named "partial rationalism", is defended. Partial rationalism states that, in cases where several competing theories have been suggested, scientists are rational just in case they accept the essential elements of each of the scientific theories on offer. This novel position subverts the existing literature on scientific "revolutions", as it sometimes demands that scientists devise a synthesis between competing scientific theories, instead of "choosing" only one. The philosophical points defended in this thesis are illustrated and supported by case studies from the history of science, including Fresnel’s wave theory of light, the Copernican revolution, the "neo-Darwinian synthesis" in evolutionary biology, the "prion revolution" in molecular biology, the miasma theory of disease, and the chemical revolution. (shrink)

Why should we make our beliefs consistent or, more generally, probabilistically coherent? That it will prevent sure losses in betting and that it will maximize one’s chances of having accurate beliefs are popular answers. However, these justifications are self-centered, focused on the consequences of our coherence for ourselves. I argue that incoherence has consequences for others because it is liable to mislead others, to false beliefs about one’s beliefs and false expectations about one’s behavior. I argue that the moral obligation (...) of truthfulness thus constrains us to either conform to the logic our audience assumes we use, educate them in a new logic, or give notice that one will do neither. This does not show that probabilistic coherence is uniquely suited to making truthful communication possible, but I argue that classical probabilistic coherence is superior to other logics for maximizing efficiency in communication. (shrink)

In biomedical measurement, biomarkers are used to achieve reliable prediction of, and useful causal information about patient outcomes while minimizing complexity of measurement, resources, and invasiveness. A biomarker is an assayable metric that discloses the status of a biological process of interest, be it normative, pathophysiological, or in response to intervention. The greatest utility from biomarkers comes from their ability to help clinicians (and researchers) make and evaluate clinical decisions. In this paper we discuss a specific methodological use of clinical (...) biomarkers in pharmacological measurement: Some biomarkers, called ‘surrogate markers’, are used to substitute for a clinically meaningful endpoint corresponding to events and their penultimate risk factors. We confront the reliability of clinical biomarkers that are used to gather information about clinically meaningful endpoints. Our aim is to present a systematic methodology for assessing the reliability of multiple surrogate markers (and biomarkers in general). To do this we draw upon the robustness analysis literature in the philosophy of science and the empirical use of clinical biomarkers. After introducing robustness analysis we present two problems with biomarkers in relation to reliability. Next, we propose an intervention-based robustness methodology for organizing the reliability of biomarkers in general. We propose three relevant conditions for a robust methodology for biomarkers: (R1) Intervention-based demonstration of partial independence of modes: In biomarkers partial independence can be demonstrated through exogenous interventions that modify a process some number of “steps” removed from each of the markers. (R2) Comparison of diverging and converging results across biomarkers: By systematically comparing partially-independent biomarkers we can track under what conditions markers fail to converge in results, and under which conditions they successfully converge. (R3) Information within the context of theory: Through a systematic cross-comparison of the markers we can make causal conclusions as well as eliminate competing theories. We apply our robust methodology to currently developing Alzheimer’s research to show its usefulness for making causal conclusions. (shrink)

It is often argued that while biases routinely influence the generation of scientific theories, a subsequent rational evaluation of such theories will ensure that biases do not affect which theories are ultimately accepted. Against this line of thought, this paper shows that the existence of certain kinds of biases at the generation-stage implies the existence of biases at the evaluation-stage. The key argumentative move is to recognize that a scientist who comes up with a new theory about some phenomena has (...) thereby gained an unusual type of evidence, viz. information about the space of theories that could be true of the phenomena. It follows that if there is bias in the generation of scientific theories in a given domain, then the rational evaluation of theories with reference to the total evidence in that domain will also be biased. (shrink)

Orthodox Bayesianism is a highly idealized theory of how we ought to live our epistemic lives. One of the most widely discussed idealizations is that of logical omniscience: the assumption that an agent’s degrees of belief must be probabilistically coherent to be rational. It is widely agreed that this assumption is problematic if we want to reason about bounded rationality, logical learning, or other aspects of non-ideal epistemic agency. Yet, we still lack a satisfying way to avoid logical omniscience within (...) a Bayesian framework. Some proposals merely replace logical omniscience with a different logical idealization; others sacrifice all traits of logical competence on the altar of logical non-omniscience. We think a better strategy is available: by enriching the Bayesian framework with tools that allow us to capture what agents can and cannot infer given their limited cognitive resources, we can avoid logical omniscience while retaining the idea that rational degrees of belief are in an important way constrained by the laws of probability. In this paper, we offer a formal implementation of this strategy, show how the resulting framework solves the problem of logical omniscience, and compare it to orthodox Bayesianism as we know it. (shrink)

According to the traditional Bayesian view of credence, its structure is that of precise probability, its objects are descriptive propositions about the empirical world, and its dynamics are given by conditionalization. Each of the three essays that make up this thesis deals with a different variation on this traditional picture. The first variation replaces precise probability with sets of probabilities. The resulting imprecise Bayesianism is sometimes motivated on the grounds that our beliefs should not be more precise than the evidence (...) calls for. One known problem for this evidentially motivated imprecise view is that in certain cases, our imprecise credence in a particular proposition will remain the same no matter how much evidence we receive. In the first essay I argue that the problem is much more general than has been appreciated so far, and that it’s difficult to avoid without compromising the initial evidentialist motivation. The second variation replaces descriptive claims with moral claims as the objects of credence. I consider three standard arguments for probabilism with respect to descriptive uncertainty—representation theorem arguments, Dutch book arguments, and accuracy arguments—in order to examine whether such arguments can also be used to establish probabilism with respect to moral uncertainty. In the second essay, I argue that by and large they can, with some caveats. First, I don’t examine whether these arguments can be given sound non-cognitivist readings, and any conclusions therefore only hold conditional on cognitivism. Second, decision-theoretic representation theorems are found to be less convincing in the moral case, because there they implausibly commit us to thinking that intertheoretic comparisons of value are always possible. Third and finally, certain considerations may lead one to think that imprecise probabilism provides a more plausible model of moral epistemology. The third variation considers whether, in addition to conditionalization, agents may also change their minds by becoming aware of propositions they had not previously entertained, and therefore not previously assigned any probability. More specifically, I argue that if we wish to make room for reflective equilibrium in a probabilistic moral epistemology, we must allow for awareness growth. In the third essay, I sketch the outline of such a Bayesian account of reflective equilibrium. Given that this account gives a central place to awareness growth, and that the rationality constraints on belief change by awareness growth are much weaker than those on belief change by conditionalization, it follows that the rationality constraints on the credences of agents who are seeking reflective equilibrium are correspondingly weaker. (shrink)

For simplicity, most of the literature introduces the concept of definitional equivalence only for disjoint languages. In a recent paper, Barrett and Halvorson introduce a straightforward generalization to non-disjoint languages and they show that their generalization is not equivalent to intertranslatability in general. In this paper, we show that their generalization is not transitive and hence it is not an equivalence relation. Then we introduce another formalization of definitional equivalence due to Andréka and Németi which is equivalent to the Barrett–Halvorson (...) generalization in the case of disjoint languages. We show that the Andréka–Németi generalization is the smallest equivalence relation containing the Barrett–Halvorson generalization and it is equivalent to intertranslatability, which is another definition for definitional equivalence, even for non-disjoint languages. Finally, we investigate which definitions for definitional equivalences remain equivalent when we generalize them for theories in non-disjoint languages. (shrink)

Many philosophers have claimed that Bayesianism can provide a simple justification for hypothetico-deductive inference, long regarded as a cornerstone of the scientific method. Following up a remark of van Fraassen, we analyze a problem for the putative Bayesian justification of H-D inference in the case where what we learn from observation is logically stronger than what our theory implies. Firstly, we demonstrate that in such cases the simple Bayesian justification does not necessarily apply. Secondly, we identify a set of sufficient (...) conditions for the mismatch in logical strength to be justifiably ignored as a "harmless idealization''. Thirdly, we argue, based upon scientific examples, that the pattern of H-D inference of which there is a ready Bayesian justification is only rarely the pattern that one actually finds at work in science. Whatever the other virtues of Bayesianism, the idea that it yields a simple justification of a pervasive pattern of scientific inference appears to have been oversold. (shrink)

Synchronic norms of theory choice, a traditional concern in scientific methodology, restrict the theories one can choose in light of given information. Diachronic norms of theory change, as studied in belief revision, restrict how one should change one’s current beliefs in light of new information. Learning norms concern how best to arrive at true beliefs. In this paper, we undertake to forge some rigorous logical relations between the three topics. Concerning, we explicate inductive truth conduciveness in terms of optimally direct (...) convergence to the truth, where optimal directness is explicated in terms of reversals and cycles of opinion prior to convergence. Concerning, we explicate Ockham’s razor and related principles of choice in terms of the information topology of the empirical problem context and show that the principles are necessary for reversal or cycle optimal convergence to the truth. Concerning, we weaken the standard principles of agm belief revision theory in intuitive ways that are also necessary for reversal or cycle optimal convergence. Then we show that some of our weakened principles of change entail corresponding principles of choice, completing the triangle of relations between,, and. (shrink)

I discuss several issues related to "classical" spacetime structure. I review Galilean, Newtonian, and Leibnizian spacetimes, and briefly describe more recent developments. The target audience is undergraduates and early graduate students in philosophy; the presentation avoids mathematical formalism as much as possible.

Varied evidence confirms more strongly than less varied evidence, ceteris paribus. This epistemological Variety of Evidence Thesis enjoys widespread intuitive support. We put forward a novel explication of one notion of varied evidence and the Variety of Evidence Thesis within Bayesian models of scientific inference by appealing to measures of entropy. Our explication of the Variety of Evidence Thesis holds in many of our models which also pronounce on disconfirmatory and discordant evidence. We argue that our models pronounce rightly. Against (...) a backdrop of failures of the Variety of Evidence Thesis, the intuitive case for the Variety of Evidence Thesis emerges strengthened. Our models do however not support the general case for the thesis since our explication of it fails to hold in certain cases. The parameter space of this failure is explored and an explanation for the failure is offered. (shrink)

Mathematicians, physicists, and philosophers of physics often look to the symmetries of an object for insight into the structure and constitution of the object. My aim in this paper is to explain why this practice is successful. In order to do so, I present a collection of results that are closely related to (and in a sense, generalizations of) Beth’s and Svenonius’ theorems.

The viability of metaphysics as a field of knowledge has been challenged time and again. But in spite of the continuing tendency to dismiss metaphysics, there has been considerable progress in this field in the 20th- and 21st- centuries. One of the newest − though, in a sense, also oldest − frontiers of metaphysics is the grounding project. In this paper I raise a methodological challenge to the new grounding project and propose a constructive solution. Both the challenge and its (...) solution apply to metaphysics in general, but grounding theory puts the challenge in an especially sharp focus. The solution consists of a new methodology, holistic grounding or holistic metaphysics. This methodology is modeled after a recent epistemic methodology, foundational holism, that enables us to pursue the foundational project of epistemology without being hampered by the problems associated with foundationalism. (shrink)

This is a brief, personal retrospective on developments in the treatment of scientific discovery by philosophers, since about 1970.