The value of optimality modeling has long been a source of contention amongst population biologists. Here I present a view of the optimality approach as at once playing a crucial explanatory role and yet also depending on external sources of confirmation. Optimality models are not alone in facing this tension between their explanatory value and their dependence on other approaches; I suspect that the scenario is quite common in science. This investigation of the optimality approach thus serves as a case (...) study, on the basis of which I suggest that there is a widely felt tension in science between explanatory independence and broad epistemic interdependence, and that this tension influences scientific methodology. (shrink)

Background independence begins life as an informal property that a physical theory might have, often glossed as 'doesn't posit a fixed spacetime background'. Interest in trying to offer a precise account of background independence has been sparked by the pronouncements of several theorists working on quantum gravity that background independence embodies in some sense an essential discovery of the General Theory of Relativity, and a feature we should strive to carry forward to future physical theories. This paper has two goals. (...) The first is to investigate what a world must be like in order to be truly described by a background independent theory given extant accounts of background independence. The second is to argue that there are no non-empirical reasons to be more confident in theories that satisfy extant accounts of background independence than in theories that don't. The paper concludes by drawing a general moral about a way in which focussing primarily on mathematical formulations of our physical theories can adversely affect debates in the metaphysics of physics. (shrink)

This paper considers non-standard analysis and a recently introduced computational methodology based on the notion of ①. The latter approach was developed with the intention to allow one to work with infinities and infinitesimals numerically in a unique computational framework and in all the situations requiring these notions. Non-standard analysis is a classical purely symbolic technique that works with ultrafilters, external and internal sets, standard and non-standard numbers, etc. In its turn, the ①-based methodology does not use any of these (...) notions and proposes a more physical treatment of mathematical objects separating the objects from tools used to study them. It both offers a possibility to create new numerical methods using infinities and infinitesimals in floating-point computations and allows one to study certain mathematical objects dealing with infinity more accurately than it is done traditionally. In these notes, we explain that even though both methodologies deal with infinities and infinitesimals, they are independent and represent two different philosophies of Mathematics that are not in a conflict. It is proved that texts :539–555, 2017; Gutman and Kutateladze in Sib Math J 49:835–841, 2008; Kutateladze in J Appl Ind Math 5:73–75, 2011) asserting that the ①-based methodology is a part of non-standard analysis unfortunately contain several logical fallacies. Their attempt to show that the ①-based methodology can be formalized within non-standard analysis is similar to trying to show that constructivism can be reduced to the traditional Mathematics. (shrink)

Orthodox semantics for natural language modals give rise to two puzzles for their interactions with disjunction: Ross’s puzzle and the puzzle of free choice permission. It is widely assumed that each puzzle can be explained in terms of the licensing of ‘Diversity’ inferences: from the truth of a possibility or necessity modal with an embedded disjunction, hearers infer that each disjunct is compatible with the relevant set of worlds. I argue that Diversity inferences are too weak to explain the full (...) range of data. Instead, I argue, modals with embedded disjunctions license ‘Independence’ inferences: from the truth of a modal with an embedded disjunction, hearers infer that each disjunct is an independent alternative among the relevant set of worlds. I then develop a bilateral inquisitive semantics for modals that predicts the validity of these Independence inferences. My account vindicates common intuitions about both Ross’s puzzle and the puzzle of free choice permission, and explains the full range of data. (shrink)

Toward the goal of doctoral studies, it is necessary to combine two basic characteristics of independent study. I like to call it an independent study, which would be partial to capture the whole of graduate studies. As for its high honor, the title page of dissertation in vast of universities usually use the phrase “...submitted for the partial fulfillment of doctorate degree...”. That phrase implies that the completion of dissertation would be a major part of doctoral (...) studies, but should be partial depending on some of additional factors. Idealistically, that could be the whole quality as an independent researcher or investigator, and possibly the kind of human paradigm as a prospective teacher. In any case, we would not be incorrect if we see our principal work at the graduate level learning the ways of independent scholar. In this context, I would propose some of elements to be addressed in the end to guide the paradigm of doctoral studies and especially involving the e-age. (shrink)

Much of the discussion of set-theoretic independence, and whether or not we could legitimately expand our foundational theory, concerns how we could possibly come to know the truth value of independent sentences. This paper pursues a slightly different tack, examining how we are ignorant of issues surrounding their truth. We argue that a study of how we are ignorant reveals a need for an understanding of set-theoretic explanation and motivates a pluralism concerning the adoption of foundational theory.

Is a phenomenal pain a conscious primitive or composed of more primitive phenomenal states? Are pain experiences necessarily or only contingently unpleasant? Here, I sketch how to answer such questions concerning intra-phenomenal metaphysics using the example of pain and unpleasantness. Arguments for a symmetrical metaphysical independence of phenomenal pain and unpleasant affect are presented, rejecting a composite view like the IASP definition and dimensional views. The motivating intuition of these views is explained by common binding mechanisms in consciousness and characterized (...) as fallacious if generalized. There are, however, underlying commonalities between pain perception and unpleasant affect, e.g. formal content or evolutionary ancestry. (shrink)

The scientific concepts of mental imagery and hallucinations are each used independently of the other in experiments; uses that simultaneously evoke and obscure their historical connections. To highlight one of these connections, I will begin by sketching episodes from the largely separate developmental trajectories of each concept. Considering these historical sketches side-by-side, I will argue that the independent uses of these concepts each inherited a shared set of interdependent associations. In doing so, I seek to illustrate the value of (...) examining historical connections between mental imagery and hallucinations for studying the current uses of these two concepts in neuroimaging experiments. (shrink)

This paper addresses the field of economic measurements of the value of assets, carried out by the methods of independent expert evaluation. The mathematical principles of application, within a comparative methodical approach, of additive and multiplicative models for correcting the cost of single indicator of compared objects have been considered. The differences of mathematical basis of the compared models were analyzed. It has been shown that the ambiguity in the methodology of correction procedure requires studying the advantages and disadvantages (...) of known models, as well as the justification and elaboration of recommendations for their application. Possible forms of correction representation using several alternative units of measurement have been defined; formulas for their interconnection have been built. Analytic expressions have been derived that mathematically describe the algorithms for performing the evaluation correction procedure using various forms of correction representation. The influence of the correction execution model on the characteristics of uncertainty in the independent evaluation result has been analyzed. The scope of two possible types of correction introduction models has been determined. A specific numerical example was used to demonstrate the methodological advantages of using a multiplicative model when summarizing percentage corrections. The independence of the correction result on the sequence of correction introduction has been confirmed. It is proposed to use the selected measure of partial corrections as a criterion for the adequacy of the correction introduction model. It is proved that the result of the independent expert evaluation depends on the chosen model and does not depend on the sequence of correction introduction. The reported study results are important in terms of theory and practice since they make it possible to improve the accuracy and reliability of the result of independent expert evaluation. (shrink)

This work examines the development and performance of federal independent regulatory bodies in Canada in the period up to 1979, with particular attention to the operation of legislative schemes that include executive review and appeal powers. The author assesses the impact of the exercise of these powers on the administrative law process, and proposes new models for the generation, interpretation, implementation, review, and enforcement of regulatory policy. The study includes a series of representative case studies based on documentation (...) and extensive interviews with individuals drawn from government, agencies, and other parties, including counsel for public interest groups. This enables author, writing from her experience as a participant-observer embedded in the public interest legal sector, to draw on the experiences and perspectives of a broad range of participants in the regulatory process, including but not limited to those dealing with the regulated energy, transportation, communications, and foreign investment sectors. Legal principles identified as emergent in leading judicial decisions in administrative law are used to assess the powers and practices used in executive reviews and appeals. The author finds those powers and practices to be flawed and proposes changes. The proposed models are designed to accord with emerging legal principles and avoid flaws of the types identified in the review and appeal provisions. This work, written under contract with the Administrative Law Project of the Law Reform Commission of Canada, formed one part of a comprehensive study of administrative law at the federal level in Canada. (shrink)

This study’s objective was to understand Colombian adolescents’ experiences and preferences regarding access to sexual and reproductive health services (SRHS), either alone or accompanied. A mixed-method approach was used, involving a survey of 812 participants aged eleven to twenty-four years old and forty-five semi-structured interviews with participants aged fourteen to twenty-three. Previous research shows that adolescents prefer privacy when accessing SRHS and often do not want their parents involved. Such findings align with the longstanding tendency to frame the ethical (...) principle of autonomy as based on independence in decision-making. However, the present study shows that such a conceptualization and application of autonomy does not adequately explain Colombian adolescent participants’ preferences regarding access to SRHS. Participants shared a variety of preferences to access SRHS, with the majority of participants attaching great importance to having their parents involved, to varying degrees. What emerges is a more complex and non-homogenous conceptualization of autonomy that is not inherently grounded in independence from parental involvement in access to care. We thus argue that when developing policies involving adolescents, policymakers and health professionals should adopt a nuanced “relational autonomy” approach to better respect the myriad of preferences that Colombian (and other) adolescents may have regarding their access to SRHS. (shrink)

Both John Campbell and Quassim Cassam have argued that we perceptually experience objects as mind-independent (MI), purportedly solving a problem they refer to as “Berkeley’s Puzzle.” In this paper, I will consider the same topic from a Husserlian perspective. In particular, I will clarify the idea of MI and argue that there is, indeed, a sense in which we can perceptually experience objects as MI, while also making objections to Campbell’s and Cassam’s respective arguments to the same effect. In (...) particular, I will argue that objects can be experienced as MI in the sense of the experience’s not being due to the malfunctioning of a perceptual organ, e.g., when one examines the ways in which the object displays itself, and gains confidence that there is, indeed, nothing the matter with one’s eyes. I will address the issue of MI from the perspective of Husserlian evidentialism, according to which perceptual content is conceived in terms of ways of perceptually exploring the object, thereby gaining evidence pertinent to the object and its properties, e.g., as when one takes a look at the object’s shape from a different angle, or scrutinizes its color in better lighting. (shrink)

The study was conducted to compare manual and computerized software techniques of data management and analysis in educational research. Specifically, the study investigated whether there was a significant difference in the results of Pearson correlation, independent t-test and ANOVA obtained from using manual and computerized software technique of data analyses. Three null hypotheses were formulated accordingly to guide the study. The study adopted a quasi-experimental research design where several data were generated by the researchers and (...) analyzed using manual and computerized software techniques. The data were generated to suit the required data of each statistical method of analysis. CASIO fx-991ES PLUS NATURAL DISPLAY scientific calculator and statistical tables were used for manual analysis; while data analysis tool pack of Microsoft Excel version 2013 were used for computerized software analysis. The results of the analysis revealed that both manual and computerized software techniques yielded the same results for Pearson correlation, independent t-test and ANOVA. It was concluded that though both manual and computerized techniques are reliable and dependable, computerized technique is faster and efficient in managing and analyzing data than manual technique. It was recommended, among other things, that any of the techniques should be used without fear when computing Pearson, independent t-test and one-way ANOVA as it is the same results that will be gotten. (shrink)

Philosophers of science turned to historical case studies in part in response to Thomas Kuhn's insistence that such studies can transform the philosophy of science. In this issue Joseph Pitt argues that the power of case studies to instruct us about scientific methodology and epistemology depends on prior philosophical commitments, without which case studies are not philosophically useful. Here I reply to Pitt, demonstrating that case studies, properly deployed, illustrate styles of scientific work and modes of argumentation that are not (...) well handled by currently standard philosophical analyses. I illustrate these claims with exemplary findings from case studies dealing with exploratory experimentation and with interdisciplinary cooperation across sciences to yield multiple independent means of access to theoretical entities. The latter cases provide examples of ways that scientists support claims about theoretical entities that are not available in work performed within a single discipline. They also illustrate means of correcting systematic biases that stem from the commitments of each discipline taken separately. These findings illustrate the transformative power of case study methods, allow us to escape from the horns of Pitt's "dilemma of case studies," and vindicate some of the post-Kuhn uses to which case studies have been put. (shrink)

Physicist Percy Bridgman has been taken by Heather Douglas to be an exemplar defender of an untenable value-free ideal for science. This picture is complicated by a detailed study of Bridgman's philosophical views of the relation between science and society. The normative autonomy of science, a version of the value-free ideal, is defended. This restriction on the provenance of permissible values in science is given a basis in Bridgman's broader philosophical commitments, most importantly, his view that science is primarily (...) an individual commitment to a set of epistemic norms and values. Considerations of external moral or social values are not, on this view, intrinsic to scientific practice, though they have a broader pragmatic significance. What Bridgman takes as the proper relation between science and society is shown through analysis of his many writings on the topic and consideration of his rarely remarked upon involvement in the most problematic example of "Big Science" of his day: the atomic bomb. A reevaluation of Bridgman's views provides a unique characterization of what is at stake in the values in science debate: the normative autonomy of science. (shrink)

Autism has been defined as a disorder of social cognition, interaction and communication where ritualistic, repetitive behaviors are commonly observed. But how should we understand the behavioral and cognitive differences that have been the main focus of so much autism research? Can high-level cognitive processes and behaviors be identified as the core issues people with autism face, or do these characteristics perhaps often rather reflect individual attempts to cope with underlying physiological issues? Much research presented in this volume will point (...) to the latter possibility, i.e. that people on the autism spectrum cope with issues at much lower physiological levels pertaining not only to Central Nervous Systems (CNS) function, but also to peripheral and autonomic systems (PNS, ANS) (Torres, Brincker, et al. 2013). The question that we pursue in this chapter is what might be fruitful ways of gaining objective measures of the large-scale systemic and heterogeneous effects of early atypical neurodevelopment; how to track their evolution over time and how to identify critical changes along the continuum of human development and aging. We suggest that the study of movement variability—very broadly conceived as including all minute fluctuations in bodily rhythms and their rates of change over time (coined micro-movements (Figure 1A-B) (Torres, Brincker, et al. 2013))—offers a uniquely valuable and entirely objectively quantifiable lens to better assess, understand and track not only autism but cognitive development and degeneration in general. This chapter presents the rationale firstly behind this focus on micro-movements and secondly behind the choice of specific kinds of data collection and statistical metrics as tools of analysis (Figure 1C). In brief the proposal is that the micro-movements (defined in Part I – Chapter 1), obtained using various time scales applied to different physiological data-types (Figure 1), contain information about layered influences and temporal adaptations, transformations and integrations across anatomically semi-independent subsystems that crosstalk and interact. Further, the notion of sensorimotor re-afference is used to highlight the fact that these layered micro-motions are sensed and that this sensory feedback plays a crucial role in the generation and control of movements in the first place. In other words, the measurements of various motoric and rhythmic variations provide an access point not only to the “motor systems”, but also access to much broader central and peripheral sensorimotor and regulatory systems. Lastly, we posit that this new lens can also be used to capture influences from systems of multiple entry points or collaborative control and regulation, such as those that emerge during dyadic social interactions. (shrink)

Patrick Toner has recently criticized accounts of substance provided by Kit Fine, E. J. Lowe, and the author, accounts which say (to a first approximation) that substances cannot depend on things other than their own parts. On Toner’s analysis, the inclusion of this parts exception results in a disjunctive definition of substance rather than a unified account. In this paper (speaking only for myself, but in a way that would, I believe, support the other authors that Toner discusses), I first (...) make clear what Toner’s criticism is, and then I respond to it. Including the parts exception is not the adding of a second condition but instead the creation of a new single condition. Since it is not the adding of a condition, the result is not disjunctive. Therefore, the objection fails. (shrink)

Objective Our study sought to (1) describe the practices and preferences of Colombian adolescents in accessing sexual and reproductive health services: accompanied versus alone; (2) compare actual practices with stated preferences; and (3) determine age and gender differences regarding the practice and these stated preferences. -/- Methods 812 participants aged 11–24 years old answered a survey in two Profamilia clinics in the cities of Medellin and Cali in Colombia. A cross-sectional analysis was performed to compare participants’ answers based on (...) the variables of gender and age. -/- Results A quarter of participants visited the clinic alone (25.4%). Females were more likely to go alone in comparison to males (26.3% vs 14.1%; p = 0.031), and older participants went alone more often than younger participants (p < 0.001). Most participants – 72.7% (95 %CI: 69.3–75.9) – expressed a preference in being accompanied to the clinic, and more than 90% had their preferences met. The preferences of older participants were, however, less likely to be met than those of younger participants (p < 0.001), notably, because they predominantly wanted to be accompanied. -/- Conclusion Contemporary public health and bioethics literature advocates in favor of developing health services that better meet the preferences of adolescents. The present research highlights an apparent blind spot related to the role that others (e.g., parents, friends, partners) can or should play in accompanying adolescent patients when they access sexual and reproductive health services. Respecting adolescents’ preferences, and hence their autonomy, is not simply a matter of ensuring freedom from constraints (e.g., their right and ability to go alone). Rather, it should also consider the liberty to choose whether to be accompanied when accessing SHRS and by whom. (shrink)

Levins and Lewontin have contributed significantly to our philosophical understanding of the structures, processes, and purposes of biological mathematical theorizing and modeling. Here I explore their separate and joint pleas to avoid making abstract and ideal scientific models ontologically independent by confusing or conflating our scientific models and the world. I differentiate two views of theorizing and modeling, orthodox and dialectical, in order to examine Levins and Lewontin’s, among others, advocacy of the latter view. I compare the positions of (...) these two views with respect to four points regarding ontological assumptions: (1) the origin of ontological assumptions, (2) the relation of such assumptions to the formal models of the same theory, (3) their use in integrating and negotiating different formal models of distinct theories, and (4) their employment in explanatory activity. Dialectical is here used in both its Hegelian–Marxist sense of opposition and tension between alternative positions and in its Platonic sense of dialogue between advocates of distinct theories. I investigate three case studies, from Levins and Lewontin as well as from a recent paper of mine, that show the relevance and power of the dialectical understanding of theorizing and modeling. (shrink)

In this issue of Studies in Transcendental Philosophy five scholars enquire about the theoretical aspects of Kant’s transcendental philosophy related to the notions of subject, self-consciousness, and self-knowledge. Andrew Brook examines Kant’s views on transcendental apperception at the end of the Critical Period, focusing on Opus Postumum which contains some of Kant’s most important reflections on the subjective dimension. As is known, the self-conscious act designated by the proposition ‘I think’ is an act of spontaneity, and this spontaneity is the (...) reason that the subject calls itself an intelligence. In his article Addison Ellis examines the theoretical and practical dimension of spontaneity, calling into question the distinction between a merely ‘relative’ spontaneity and one that is ‘absolute’. Luca Forgione points to two forms of self-consciousness introduced by Kant: inner sense, based on a sensory form of self-awareness, and transcendental apperception. Through the notion of inner sense, Kant also allows for an introspective account of self-awareness; nonetheless, Kant holds an utterly sophisticated notion of basic self-consciousness provided for by the notion of transcendental apperception. Roberto Horácio de Sá Pereira’s article presents a systematic and a historical approach, linking the contemporary debate on transcendental argument to Kant’s philosophy. It addresses both Stroud’s objection and Strawson’s perspective on transcendental argument and introduces a new reconstruction of Kant’s Refutation as successful truth-directed transcendental argument. In contrast to the contemporary movement of transhumanism and its claims that creatures like us can exist independently of our bodies, Robert Hanna develops a generalist perspective on the subjective dimension, according to which all rational human creature are synthetic a priori necessarily, essentially embodied Kantian selves. I would like to thank the authors for participating in this issue and for helping to make it really special. (shrink)

Tragedies, as real-world phenomena, are independent of their literary genre and are suitable for philosophical analysis. My analysis focuses on a type of tragedy that emerges in the practical lives of individuals in a broad sense. Tragedies often manifest in mundane, everyday situations. However, the fact that a situation is tragic does not mean that any unfortunate event that happens to an individual qualifies as a tragedy, nor does it imply that any practical pursuit is a tragic candidate. Instead, (...) these practical tragedies occur when the world obstructs pursuits that are fundamentally valuable. Tragedies are frequently dramatized in specific contexts such as moral dilemmas and historical calamities. Yet, these are merely instances of how the world can oppose what matters more universally. (shrink)

High school students are in the stage of Adolescence and it is the time for developing independence. Typically, adolescents exercise their independence by questioning and sometimes by breaking rules. Parents and teachers must play a major role in supporting & influencing the children positively by their ethical & appropriate approaches. Teachers in school as well as parent at home, often wonder how to disciple a child and to mould their behaviour so to bring up the child with virtues. Although some (...) children truly have challenging behaviours regardless of what strategies to try, many children just need to have the adults in their lives make changes in the way they react, respond, or interact with them. It is also a great responsibility of the teacher in school to have positive approach towards students. If not there are possibilities in change of behaviour among students & leads to several problems. For example, frequent episodes of fighting, scholastic backwardness, substance abuse; antisocial or institutional activities, destructive behaviour and change in attitude in students are much more significant than isolated episodes of the same activities. Other warning signs include deterioration of performance at school and running away from home. This research paper’s aim is the teacher-students relationship and its impact on the behaviour of High school students. The objectives are to know the teachers attitudes both positive and negative towards students and its impact to bring positive as well as negative behaviour change in the students. The study has reported that students are often facing emotional problems by the negative approach of the teachers. It is recommended that to create awareness among teachers in the school for the smooth handling the children with the positive approaches. 50 high school students; 25 girls and 25 boys were taken and interview schedule is used. Both the primary and secondary methods are used and the study is descriptive in nature. (shrink)

The nature of existence, which science seeks to investigate, is dynamic as novel discoveries are constantly presented. To explain such a dynamic existence, science itself needs to be dynamic. Methodological differentiation is one way in which science expresses dynamism. Such differentiation led to the theological and the natural sciences, and conflicting views regarding the nature of existence: the theological worldview versus the natural worldview. This study is a comparison of the conflicting worldviews of the theological and cosmological theories of (...) the beginning of existence. The study compares them in an attempt to redress the conflict and encourage dialogue between the two methods for a better representation of existence. The study exposes the limits of the theological and the natural worldviews. It proposes a relationship of dialogue between them so that they transcend their individual limits and are able to grow. Dialogue involves the interchange of ideas to broaden perspectives, which leads to growth. A relationship of dialogue emphasises similarities in presuppositions, methodology and content, and exploits these to attain a greater degree of certitude. Theology and natural science can be viewed analogically as two sides of the same coin, two aspects to one reality, that can collaborate, albeit independently, to reveal a broader view of reality. They can converse through dialogue, exchange ideas and share views, even though they remain methodologically exclusive, independent worldviews. Finally, dialogue involves a transformation of reason in that it expects theologians and natural scientists to change the way they view reality. If we were to transform our reasoning into something more complete, our worldview should represent a more complete representation of existence. This means that the theologian and the scientist can, occasionally, go beyond their scope and method and push their knowledge towards progress through dialogue. This makes “transformed reason” the method of dialogue, which redresses the conflict between theology and natural science and encourages interchange between them. (shrink)

The Two Selves takes the position that the self is not a "thing" easily reduced to an object of scientific analysis. Rather, the self consists in a multiplicity of aspects, some of which have a neuro-cognitive basis (and thus are amenable to scientific inquiry) while other aspects are best construed as first-person subjectivity, lacking material instantiation. As a consequence of their potential immateriality, the subjective aspect of self cannot be taken as an object and therefore is not easily amenable to (...) treatment by current scientific methods. -/- Klein argues that to fully appreciate the self, its two aspects must be acknowledged, since it is only in virtue of their interaction that the self of everyday experience becomes a phenomenological reality. However, given their different metaphysical commitments (i.e., material and immaterial aspects of reality), a number of issues must be addressed. These include, but are not limited to, the possibility of interaction between metaphysically distinct aspects of reality, questions of causal closure under the physical, the principle of energy conservation. -/- After addressing these concerns, Klein presents evidence based on self-reports from case studies of individuals who suffer from a chronic or temporary loss of their sense of personal ownership of their mental states. Drawing on this evidence, he argues that personal ownership may be the factor that closes the metaphysical gap between the material and immaterial selves, linking these two disparate aspects of reality, thereby enabling us to experience a unified sense of self despite its underlying multiplicity. -/- . (shrink)

I argue that using information from a cognitive representation to guide the performance of a primary task is sufficient for intellectual attention, and that this account of attention is endorsed by scientists working in the refreshing, n-back, and retro-cue paradigms. I build on the work of Wayne Wu, who developed a similarly motivated account, but for perceptual attention rather than intellectual attention. The way that I build on Wu’s account provides a principled way of responding to Watzl’s challenge to Wu, (...) according to which Wu’s style of account is unintuitively broad. The fact that I find unity in the practice of science puts us in a position to resist the claim that scientists studying intellectual attention are frequently failing to study the same thing. (shrink)

Rabindranath Tagore (1861–1941), at about the start of the nineteenth century, was advocat‐ ing that the study about religion has to be included in university‐level education in the East. The university he envisioned and founded (Visva‐Bharati) included in its curriculum such a study. Shortly a er India’s regaining independence in 1947 and becoming a secular state, that institution was inaugurated as a central university with an advanced institute for philosophy and the study of religion. This essay answers (...) whether his understanding of studying religion would accommodate the approach to the academic study of religion associated with the mod‐ ern Western research university. It also inquires the extent that the curriculum for the study of religion at Visva‐Bharati evidences such an approach. The answers it advances draw primarily on his two essays, Eastern University and Hindu University, which o er his vision of univer‐ sity level education; on commissioned reports for higher level education in the new India as a secular state; on developments in the academic study of religion in the West, especially the United States; on the relatively recent revised curriculum for such a study at Visva‐Bharati University; and on ideas of social imaginary and the comparative study of religion articulated by Western scholars. (shrink)

For a transitional market with a short history like that of Vietnam, corporate governance is a critical area of improvement. The issuance of Circular 121 in 2012 marked an important milestone of corporate governance reform in Vietnam as it includes stricter and more well-defined regulations learned from international best practices. Among them is the requirement that independent directors should make up at least one-third of the board of directors. Although improving financial reporting is not at the heart of Circular (...) 121, this Circular is expected to reduce earnings management through the mandatory requirement of board independence. Using data collected from a sample of 523 non-financial listed firms from 2009 – 2016, this study finds no significant relationship between earnings management and the proportion of independent directors, and Circular 121 has no impact on this relationship. These results are consistent across different regression approaches and various robustness tests, suggesting that board independence and corporate governance reform are not effective tools in mitigating earnings management. (shrink)

Despite the ubiquity of knowledge attribution in human social cognition, its associated neural and cognitive mechanisms are poorly documented. A wealth of converging evidence in cognitive neuroscience has identified independent perspective-taking and inhibitory processes for belief attribution, but the extent to which these processes are shared by knowledge attribution isn't presently understood. Here, we present the findings of an EEG study designed to directly address this shortcoming. These findings suggest that belief attribution is not a component process in (...) knowledge attribution, contra a standard attitude taken by philosophers. Instead, observed differences in P3b amplitude indicate that knowledge attribution doesn't recruit the strong self-perspective inhibition characteristic of belief attribution. However, both belief and knowledge attribution were observed to display a late slow wave widely associated with mental state attribution, indicating that knowledge attribution also shares in more general processing of others' mental states. These results provide a new perspective both on how we think about knowledge attribution, as well as Theory of Mind processes generally. (shrink)

The present study examined the relationship between left–right discrimination (LRD) performance and handedness, sex and cognitive abilities. In total, 31 men and 35 women – with a balanced ratio of left-and right-handers – completed the Bergen Left–Right Discrimination Test. We found an advantage of left-handers in both identifying left hands and in verifying “left” propositions. A sex effect was also found, as women had an overall higher error rate than men, and increasing difficulty impacted their reaction time more than (...) it did for men. Moreover, sex interacted with handedness and manual preference strength. A negative correlation of LRD reaction time with visuo-spatial and verbal long-term memory was found independently of sex, providing new insights into the relationship between cognitive skills and performance on LRD. (shrink)

Arrhenius’s impossibility theorems purport to demonstrate that no population axiology can satisfy each of a small number of intuitively compelling adequacy conditions. However, it has recently been pointed out that each theorem depends on a dubious assumption: Finite Fine-Grainedness. This assumption states that there exists a finite sequence of slight welfare differences between any two welfare levels. Denying Finite Fine-Grainedness makes room for a lexical population axiology which satisfies all of the compelling adequacy conditions in each theorem. Therefore, Arrhenius’s theorems (...) fail to prove that there is no satisfactory population axiology. In this paper, I argue that Arrhenius’s theorems can be repurposed. Since all of our population-affecting actions have a non-zero probability of bringing about more than one distinct population, it is population prospect axiologies that are of practical relevance, and amended versions of Arrhenius’s theorems demonstrate that there is no satisfactory population prospect axiology. These impossibility theorems do not depend on Finite Fine-Grainedness, so lexical views do not escape them. (shrink)

Trigonometry serves as an important precursor to calculus as well as college level courses. However, a possible factor that affects students from learning is teachers’ strategies in teaching. Several studies reveal that cooperative learning such as study group can increase achievement of students in mathematics. This study focused on the effects of study groups on the grade 9 students’ achievement in trigonometric problems. It sought to identify the achievement of the students in problem solving before and after (...) the interventions and to compare the interventions, the group taught with study groups and taught with the existing method. The study used true experimental design particularly pretest-posttest control group design. The study was analyzed through frequency count and percentage of scores, Wilcoxon rank test, and t-test for independents samples. The subjects of the study were the Grade 9 students in a public high school in Nueva Vizcaya, Philippines. The results revealed that majority of the students’ achievements increased. Moreover, the intervention with a study group and the existing method can improve the students’ performance in solving trigonometric problems. Furthermore, the result suggests that study group method was more effective than the existing method. (shrink)

‘‘COGNITIVE ECOLOGY’’ is a fruitful model for Shakespearian studies, early modern literary and cultural history, and theatrical history more widely. Cognitive ecologies are the multidimensional contexts in which we remember, feel, think, sense, communicate, imagine, and act, often collaboratively, on the fly, and in rich ongoing interaction with our environments. Along with the anthropologist Edwin Hutchins,1 we use the term ‘‘cognitive ecology’’ to integrate a number of recent approaches to cultural cognition: we believe these approaches offer productive lines of engagement (...) with early modern literary and historical studies.2 The framework arises out of our work in extended mind and distributed cognition.3 The extended mind hypothesis arose from a post-connectionist philosophy of cognitive science. This approach was articulated in Andy Clark’s Being There: Putting Brain, Body, and World Together Again, and further developed by Susan Hurley and Mark Rowlands, among others.4 The distributed cognition approach arose independently, from work in cognitive anthropology, HCI (Human-Computer Interaction), the sociology of education and work, and science studies. The principles of distributed cognition were articulated in Hutchins’s ethnography of navigation, Cogni- tion in the Wild,5 and developed by theorists such as David Kirsh and Lucy Suchman.6 These models share an anti-individualist approach to cognition. In all these views, mental activities spread or smear across the boundaries of skull and skin to include parts of the social and material world. In remembering, decision making, and acting, whether individually or in small groups, our complex and structured activities involve many distinctive dimensions: neural, affective, kines-. (shrink)

The four case studies below were designed as a workshop in a research setting. They could also be used as a lesson plan for college students. The material is divided into four case studies. One can use any of the case studies independently. One can change the order in which the case studies are used. If you want to share with me how you plan to use these case studies, communicate to me at [email protected] • Case 1: Does the Bible (...) require that marriage be limited to one man and one woman? • Case 2: Matthew Vines, a fervent believer wrestling with loneliness • Case 3: Does the Bible support the contention that marriage rules never change? • Case 4: The Emergence and Disappearance of Levirate Marriages . (shrink)

The literature on the history of electricity production have studied the evolution of electricity in both developed and developing countries and its impact on their economies. Some have laid foundations upon which other works are carried out. A close examination of historiography and multidisciplinary research on electricity production in Ghana shows that more efforts are required to improve the electric power landscape in Ghana. From the colonial era, the increasing demand for electricity has been the biggest challenge plaguing the energy (...) sector. Respective governments have made significant strides in ensuring reliable and universal access to electricity throughout Ghana, yet such efforts have been accompanied by different levels of challenges. The study uses a qualitative and exploratory research approach to trace the activities that helped, in many other ways to the creation of a sustainable electric power provision to household and industry in Ghana, particularly in two of Ghana’s cities; Accra and Kumasi, within the period 1900 to the1960s. The work focused mainly on archival sources in its quest to arrive at how indigenous Ghanaians provided power for industrial activities and for household purposes. Results from the study show that local and cottage industries relied predominantly on wood, fuel, and biomass for their operations even before the introduction of the more sophisticated means of power generation. Also, the study revealed that in finding solutions to the challenges of electricity production, policymakers have focused more on current issues with little or no effort to trace the historical foundation of electricity production. This notwithstanding, the little efforts that have been made examined the history of energy production, with a limited focus on the immediate post-independence era. (shrink)

Within the framework of Positive Psychology and Needing Theories, this article reviews cultural practices or perceptions regarding what happiness is and how it can be achieved. Mainly research on Subjective Well-Being (SWB) has identified many cultural differences in the pursuit of happiness, often described as East-West splits along categories such as highly expressed affect vs. quiet affect, self-assertion vs. conformity to social norms, independence vs. interdependence and the like. However, it is the overall goal of this article to show that (...) whatever the normative content of a culture’s or subculture’s view of happiness may be, it involves the same basic psychological needs beyond how people may choose to report or express resulting emotions. In particular, the theory of happiness proposed by the Hellenistic philosopher Epicurus provides broader, more inclusive categories and concepts which can be used to explain and possibly harmonize assumptions from particular traditions. (shrink)

In 1919, as the Crow (Apsáalooke) Nation was being forced by the federal government to allot the “surplus” lands on their reservation, tribal member Robert Yellowtail spoke before the United States Senate Committee on Indian Affairs in a speech entitled, “In Defense of The Rights of The Crow Indians and The Indians Generally.” To establish the context of the speech, a brief history of the Apsáalooke Indian nation and tribal member Robert Yellowtail will be given within the framework of United (...) States Indian policy relevant to assimilation and allotment at the time. Classical liberalism, its political philosophy of property and government, illuminates Yellowtail’s arguments through a generative rhetorical analysis. The implications of the analysis are discussed as a case study of liberal political philosophy utilized to make the case for the rights of American Indians to self-determination in a direct challenge to the dominant United States Indian policy paradigm at the time. Contrary to American founding principles, American Indians had been subjected to the same paternalizing policy strategies underlying the July 4th, 1776 rebellion of the American colonies against the British crown. Yellowtail skillfully brought these inconsistencies to light, challenging the paternal paradigm by using the key terms and concepts of classical liberal political philosophy as used by the American Founding Fathers. (shrink)

The author has established a mathematical theory about the system of freedom in which components of freedom are ruled by the largest freedom principle, explaining how one invariant reality can be equated with the dynamical universe. Freedom as a whole is the reality, and components of freedom show variable phenomena and become a dynamic system. In freedom, component equality leads to sequence equality; therefore, various sequences coexist in the system. Because there are incompatible sequences for any sequence, the interior of (...) freedom cannot be a static sequence. In order for the system to be a whole, there must be some connecting sequences between any two sequences. Then, at every part of freedom, it is always possible to find a group of three independent sequences that, for most components, is located inside. For the sequence group, there is a sequence through which most components flow in and out. The most abundant three - sequence group and most abundant connecting sequence correspond to the space - time structure. Other incompatible sequences correspond to particles, and interactions between these sequences correspond to interactions between particles. The interactions have some symmetries similar to those in physics, such as SU (3) AND SU (2)×U (1), thus proving the feasibility of the hypothesis: the universe is equivalent with the system of freedom. (shrink)

In this review, we describe some of the central philosophical issues facing origins-of-life research and provide a targeted history of the developments that have led to the multidisciplinary field of origins-of-life studies. We outline these issues and developments to guide researchers and students from all fields. With respect to philosophy, we provide brief summaries of debates with respect to (1) definitions (or theories) of life, what life is and how research should be conducted in the absence of an accepted theory (...) of life, (2) the distinctions between synthetic, historical, and universal projects in origins-of-life studies, issues with strategies for inferring the origins of life, such as (3) the nature of the first living entities (the “bottom up” approach) and (4) how to infer the nature of the last universal common ancestor (the “top down” approach), and (5) the status of origins of life as a science. Each of these debates influences the others. Although there are clusters of researchers that agree on some answers to these issues, each of these debates is still open. With respect to history, we outline several independent paths that have led to some of the approaches now prevalent in origins-of-life studies. These include one path from early views of life through the scientific revolutions brought about by Linnaeus (von Linn.), Wöhler, Miller, and others. In this approach, new theories, tools, and evidence guide new thoughts about the nature of life and its origin.We also describe another family of paths motivated by a” circularity” approach to life, which is guided by such thinkers as Maturana & Varela, Gánti, Rosen, and others. These views echo ideas developed by Kant and Aristotle, though they do so using modern science in ways that produce exciting avenues of investigation. By exploring the history of these ideas, we can see how many of the issues that currently interest us have been guided by the contexts in which the ideas were developed. The disciplinary backgrounds of each of these scholars has influenced the questions they sought to answer, the experiments they envisioned, and the kinds of data they collected. We conclude by encouraging scientists and scholars in the humanities and social sciences to explore ways in which they can interact to provide a deeper understanding of the conceptual assumptions, structure, and history of origins-of-life research. This may be useful to help frame future research agendas and bring awareness to the multifaceted issues facing this challenging scientific question. (shrink)

The role of the Ready-made Garment (RMG) sector in transforming the lives of working women in Bangladesh has been controversial. This study examines the impact of paid employment in the RMG sector on the empowerment of its female workers. The fieldwork includes semi-structured interviews with female garment workers to explore their lived experiences and views. The primary qualitative data analysis draws principally on Kabeer's (1999) three inter-related dimensions (resources, agency, and achievements) of empowerment. The main findings of the research (...) are that women with access to employment opportunities in this sector have become economically empowered and independent. The higher economic capacity gives them greater autonomy and makes them confident to make some household and strategic life choices. Increased access to public spaces and consciousness about their right to make life choices have boosted their self-esteem. The study concludes that paid employment in the RMG sector has a significant positive impact on the economic, social, and psychological empowerment of female workers in the readymade garments sector. However, some critical constraints in the sector continue to limit their potential for being further empowered. The findings offer valuable insights for practitioners and policymakers. (shrink)

ABSTRACT For learning any language, motivation plays a vital role. This study aims to investigate collegiate students’ predictive motivational factors toward students’ attitude toward learning English as secondary language. This is a cross-sectional study in which questionnaire was adapted from the existing literature for data collection. For this quantitative study data were collected from two government degree colleges of Larkana. Total 400 questionnaires were randomly distributed among intermediate students both boys and girls, out of that 247 were (...) returned. Data were analyzed using statistical packages for social sciences (SPSS) version 24. Initially, data were cleaned by identifying missing values and outliers. Study hypotheses were examined using Multiple Regression Analysis (MRA). The findings of this study revealed that instrumental motivation and parental encouragement (independent variables) have positive and significant relationship with attitude toward learning English. However, one variable i.e. integrative motivation was not found as a significant and positive predictor of the dependent variable. Like any study, this study also possesses few limitations, such as sample size, time horizon, and context of the study. In the end, future directions are given for further exploration. (shrink)

.........................Turkish ....................... Çalışmanın konusu dindarlık eğilimi ile meslekî tükenmişlik arasındaki ilişkidir. Dindarlık eğilimine göre meslekî tükenmişlik düzeyinde herhangi bir farklılık olup olmadığı ise çalışmanın temel problemini oluşturmuştur. Bu bağlamda meslekî tükenmişlik düzeyini ve dindarlık eğilimini belirlemek için kolayda örnekleme yöntemiyle Gümüşhane il merkezindeki ilkokul, ortaokul ve liselerde görev yapan farklı branşlardaki öğretmenlerden bir örneklem grubu oluşturulmuştur. Elde edilen meslekî tükenmişlik ve dindarlık eğilimi verilerinden yola çıkarak bu iki değişkenin ilişkisi araştırılmıştır. Çalışmada Frekans, Bağımsız t-Testi, Tek Yönlü Varyans AnaliziANOVA testleri kullanılmıştır. (...) Bunun yanında hesaplanan değerleri ve elde edilen verileri değerlendirmek için SPSS (16.0) istatistik paket programı kullanılmıştır. Araştırma iki bölümden oluşmuştur. İlk bölümde dindarlık eğilimi ile meslekî tükenmişlik ilişkisine teorik bir yaklaşım sunulmuştur; meslekî tükenmişlik ve dindarlık kavramı, meslekî tükenmişlikle ilgili yurt içinde ve yurt dışında yapılan araştırmalar ve son olarak da meslekî tükenmişlik ile dindarlık eğilimi arasındaki ilişkiden bahsedilmiştir. İkinci bölümde uygulama kısmı, çalışmanın problemi ve alt problemleri, hipotezler, evren ve örneklem, kullanılan ölçekle ilgili sınırlıklar, çalışma bulgularının analizi, bulguların tartışılması, sonuçlar ve çalışmanın önerileri sunulmuştur. Çalışmanın sonuçlarına göre meslekî tükenmişlik puanları cinsiyet değişkenine göre farklılaşmazken, sosyo-ekonomik durum değişkenine göre anlamlı farklılık göstermiştir. Bunun yanında dindarlık eğilimine yönelik anket maddeleri ile meslekî tükenmişlik puanları arasında anlamlı düzeyde farklılaşmalara ulaşılmıştır. Sonuç olarak dindarlık eğiliminin meslekî tükenmişliğe etki eden faktörlerden biri olduğu tespit edilmiştir. -/- ...................................English ...................... Subject of this study is correlation of occupational burnout with the tendency of religiosity. Our main problem consists of that whether to be any differences in occupational burnout level according to the tendency of religiosity. In this context, it has been propounded that the levels of occupational burnout and tendency of religiosity of a sample group which consists of teachers chosen convenience sampling method from primary schools, secondary schools and high schools in Gümüşhane province. Based on the resulting occupational burnout and tendency of religiosity, investigated the correlation between these two variables. In the study the Frequency, Independent t-Test and One Way Variance Analysis-ANOVA tests were used and the evaluation of data and finding calculated values, SPSS (16.0) statistics software package were used. According to the results of the survey, the occupational burnout scores a differentiation has not been shown according to gender when has been established a significant difference according to socioeconomic status variable as independent variables. Besides, have been established a significant difference between tendency of religiosity of items and occupational burnout scale scores. The study consists of two main parts. In the first part, to provide a theoretical approach to the relationship of occupational burnout and tendency of religiosity; the concept of occupational bornout, the studies made on occupational burnout in domestic and abroad, and finally the relation of occupational burnout and tendency of religiosity have been mentioned. In the second part, considered as part of practice, the problem of the study and sub problems, hypothesis, population and sample, limitations information about the scale used in the study, analyzing the findings of the study, discussing the findings and conclusions and recommendations of the study have been presented. (shrink)

The acclaim accorded Jiddu ‘Krishnamurti’ (1895-1986) – as an apparently major figure in our modern understanding of all things spiritual – shows just how shallow western popular culture is when it tries to extend its reach beyond science, materialism and celebrity. Krishnamurti liked to portray himself as a wholly independent thinker, and as someone who encouraged similar independence of thought in others, yet he milked the role of an oriental guru tirelessly, discoursing from on high in an autocratic and (...) commanding manner. At best his vast body of transcribed teachings is diverting nonsense; at worst he’s wasting our time. -/- keywords: criticism critical analysis critique Jiddu Krishnamurti assessment evaluation appraisal. (shrink)

Philosophical tradition has long held that free will is necessary for moral responsibility. We report experimental results that show that the folk do not think free will is necessary for moral responsibility. Our results also suggest that experimental investigation of the relationship is ill served by a focus on incompatibilism versus compatibilism. We propose an alternative framework for empirical moral psychology in which judgments of free will and moral responsibility can vary independently in response to many factors. We also suggest (...) that, in response to some factors, the necessity relation may run from responsibility to free will. (shrink)

Hume's Treatise of Human Nature was published in the form of three separate books. The first two, "Of the Understanding" and "Of the Pas- sions," were published in London in January 1739 by John Noon. The third, "Of Morals," was published independently in London by Thomas Longman in November 1740.2 The title and subtitles on all three books are the same: A Treatise of Human Nature: Being An Attempt to introduce the experimental Method of Reasoning into Moral Subjects. On the (...) title page of the first two books Hume employs an epigram from Tacitus: Rara temporumfelicitas, ubi sentire, quae velis; & quae sentias, dicere licet. ["Seldom are men blessed with times in which they may think what they like and say what they think."] On the title page of the third book this epigram is replaced by an epigram taken from the ninth book of Lucan's Pharsalia: Durae semper virtutis amator, Quaere quid est virtus, et posce exemplar honesti. ["Thou that to virtue ever wer't inclined, learn what it is, how certainly defin'd, and leave some perfect Rule to guide Mankind."] Given the context and the prominence of these epigrams, it is a curious fact that they have attracted little or no attention or comment from Hume scholars. -/- In this paper I argue that Hume's use of the epigram from Lucan is directly relevant to his use of the epigram from Tacitus. The epigrams flag very clearly the anti-Christian nature of Hume's intentions in the Treatise and his affiliations with and allegiance to an anti-Christian tradition of thought that stretches from Hobbes and Spinoza in the late seventeenth century to a circle of anti-Newtonian radical freethinkers that appeared in Britain in the first part of the eighteenth century. In more general terms these epigrams are a notable and illuminating example of esoteric communication in this context, and they indicate that the Treatise has an important place in the literature of the radical enlightenment. (shrink)

This article aims to present a detailed analysis of the “Christian natural philosophy” elaborated by the German humanist philosopher and theologian Otto Casmann (1562–1607) in his various works. To this end, Casmann’s general idea of philosophia Christiana is discussed and critically evaluated. Regarding natural philosophy, or physics, attention is paid mainly to topics such as cosmogony and cosmology, which Casmann promised to have developed biblically and independently of the pagan (namely Aristotelian) tradition. However, when Casmann’s natural philosophy is analyzed in (...) detail, his resolute emphasis on the literal reading of the Bible, the cornerstone of his entire concept, turns out to be problematic. Similarly, despite his resolutions, his natural‑philosophical views are, to a considerable extent, still dependent on Aristotelian terms and concepts. (shrink)

Ontology has been proposed as a solution to the 'Tower of Babel' problem that threatens the semantic interoperability of information systems constructed independently for the same domain. In information systems research and applications, ontologies are often implemented by formalizing the meanings of words from natural languages. However, words in different natural languages sometimes subdivide the same domain of reality in terms of different conceptual categories. If the words and their associated concepts in two natural languages, or even in two terminological (...) traditions within the same language, do not have common referents in the real world, an ontology based on word meanings will inherit the 'Tower of Babel' problem from the languages involved, rather than solve it. In this paper we present evidence from a preliminary comparison of landscape terms in English with those in the Yindjibarndi language of northwestern Australia demonstrating that this problem is not just hypothetical. Some possible solutions are suggested. (shrink)

Ontology has been proposed as a solution to the 'Tower of Babel' problem that threatens the semantic interoperability of information systems constructed independently for the same domain. In information systems research and applications, ontologies are often implemented by formalizing the meanings of words from natural languages. However, words in different natural languages sometimes subdivide the same domain of reality in terms of different conceptual categories. If the words and their associated concepts in two natural languages, or even in two terminological (...) traditions within the same language, do not have common referents in the real world, an ontology based on word meanings will inherit the 'Tower of Babel' problem from the languages involved, rather than solve it. In this paper we present evidence from a preliminary comparison of landscape terms in English with those in the Yindjibarndi language of northwestern Australia demonstrating that this problem is not just hypothetical. Some possible solutions are suggested. (shrink)

Abstract: Background: Coronary artery disease remains the leading cause of morbidity and mortality Worldwide. Previous reviews pointed that nursing interventions are beneficial for coronary artery patients. However, most interventions focused on education and counselling, but not consistent with the outcome set; still did not consider patient’s coronary artery disease risky characteristics. Related studies in China also difficult to find. Therefore this study was conducted to investigate kinds of nursing interventions delivered to coronary artery patients and match them with patient’s (...) risk factors of coronary artery disease. Results of this study were expected to add new knowledge that will alert nurses to consider coronary artery risk factors which in turn might enable the development of appropriate approaches to improve patient’s wellbeing hence reduce frequent coronary artery morbidity and mortality. Methods: A descriptive, cross-sectional, retrospective design using clinical case notes was employed. Study was undertaken in coronary care wards at the teaching hospital in China from November 2017 to September 2018. Structured-literature supported self-designed questionnaire was utilized for data collection. Chi square (χ2) test and multivariate logistic regression for adjusted odds ratio with 95% confidence interval were used to compare the relationship among independent (patient’s risk coronary artery disease factors) and dependent (nursing interventions) categorical variables. Ethical permission was granted accordingly. Results: A total of 300 coronary artery patients’ case notes were audited with mean age 63±11.2 years. Of these 175 (58.3%) were males. 126(42%) were smoking and 224(74.7%) were hypertensive. More evidence based nursing interventions than education and counselling were found to be delivered to these patients. “Administer coronary artery disease medication and their instructions” was mostly delivered to many patients 291(97%) while “counsel to cope with stress” was the least one 60 (20.0%). Three of eight nursing interventions delivered significantly matched with three or all of these patient’s coronary artery risk variables (age, smoking, hypertension and diabetes) (p < 0.05 and/or < 0.01) with Adjusted odds ratio (95% CI) within their significant ranges. Conclusion: This study delivers valuable insight that, nurses in the studied teaching hospital delivered beneficial evidence based nursing interventions to patients with coronary artery disease which significantly matched with their risk factors of coronary artery illness. However, care for stress was low hence needs improvement. Furthermore, research is needed to get consistency of nursing interventions with patient’s end point clinical outcomes for further appraisal of nursing efforts in caring CAD patients . (shrink)

Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and (...) [18F]-flumazenil PET in a separate group (n = 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAA receptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control. (shrink)

Following an analysis of the state of investigations and clinical outcomes in the Alzheimer's research field, I argue that the widely-accepted 'amyloid cascade' mechanistic explanation of Alzheimer's disease appears to be fundamentally incomplete. In this context, I propose that a framework termed 'principled mechanism' (PM) can help with remedying this problem. First, using a series of five 'tests', PM systematically compares different components of a given mechanistic explanation against a paradigmatic set of criteria, and hints at various ways of making (...) the mechanistic explanation more 'complete'. These steps will be demonstrated using the amyloid explanation, and its missing or problematic mechanistic elements will be highlighted. Second, PM makes an appeal for the discovery and application of 'biological principles' (BPs), which approximate ceteris paribus laws and are operative at the level of a biological cell. As such, although thermodynamic, evolutionary, ecological and other laws or principles from chemistry and the broader life sciences could inform them, BPs should be considered ontologically unique. BPs could augment different facets of the mechanistic explanation but also allow further independent nomological explanation of the phenomenon. Whilst this overall strategy can be complementary to certain 'New Mechanist' approaches, an important distinction of the PM framework is its equal attention to the explanatory utility of biological principles. Lastly, I detail two hypothetical BPs, and show how they could each inform and improve the potentially incomplete mechanistic aspects of the amyloid explanation and also how they could provide independent explanations of the cellular features associated with Alzheimer's disease. (shrink)