Results for 'Quinn W.'

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  1. What’s a rational self-torturer to do?Douglas W. Portmore - manuscript
    This paper concerns Warren Quinn’s famous “The Puzzle of the Self-Torturer.” I argue that even if we accept his assumption that practical rationality is purely instrumental such that what he ought to do is simply a function of how the relevant options compare to each other in terms of satisfying his actual preferences that doesn’t mean that every explanation as to why he shouldn’t advance to the next level must appeal to the idea that so advancing would be suboptimal (...)
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  2. The Saucer of mud, The Kudzu vine and the uxorious cheetah: Against neo-Aristotelian naturalism in metaethics.James Lenman - 2005 - European Journal of Analytic Philosophy 1 (2):37-50.
    Let me say something, to begin with, about wanting weird stuff. Stuff like saucers of mud. The example, famously, is from Anscombe’s Intention (Anscombe Anscombe 957)) where she is, in effect, defending a version of the old scholastic maxim, Omne appetitum appetitur sub specie boni. If your Latin is rusty like mine, what that says is just that every appetite – for better congruence with modern discussions, let’s say every desire – desires under the aspect of the good, or in (...)
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  3. Self-deception in and out of Illness: Are some subjects responsible for their delusions?Quinn Hiroshi Gibson - 2017 - Palgrave Communications 15 (3):1-12.
    This paper raises a slightly uncomfortable question: are some delusional subjects responsible for their delusions? This question is uncomfortable because we typically think that the answer is pretty clearly just ‘no’. However, we also accept that self-deception is paradigmatically intentional behavior for which the self-deceiver is prima facie blameworthy. Thus, if there is overlap between self-deception and delusion, this will put pressure on our initial answer. This paper argues that there is indeed such overlap by offering a novel philosophical account (...)
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  4. Blockchain Identities: Notational Technologies for Control and Management of Abstracted Entities.Quinn Dupont - 2017 - Metaphilosophy 48 (5):634-653.
    This paper argues that many so-called digital technologies can be construed as notational technologies, explored through the example of Monegraph, an art and digital asset management platform built on top of the blockchain system originally developed for the cryptocurrency bitcoin. As the paper characterizes it, a notational technology is the performance of syntactic notation within a field of reference, a technologized version of what Nelson Goodman called a “notational system.” Notational technologies produce abstracted entities through positive and reliable, or constitutive, (...)
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  5. (1 other version)Neuser, W. / Kohne, J. (ed. 2008), Hegels Licht-Konzepte.W. Neuser & J. Kohne (eds.) - 2008 - Würzburg: Königshausen & Neumann.
    Ausgangspunkt ist die Frage, was Masse ist, wodurch sie insbesondere befähigt ist, Dauer zu konstituieren und deshalb - im Sinn des kinematischen Relativitätsprinzips - ebenso als bewegt wie als ruhend betrachtet werden kann. In einem Gedankenexperiment wird diese Frage, in Umkehrung der Perspektive, hier nicht von der Masse selbst, sondern von einer stehenden Lichtwelle her angegangen. In diesem Modell lassen sich masse-analoge Strukturen rekonstruieren, die in relativer Bewegung sein können. Die (empirisch bekannte) Unabhängigkeit der Lichtgeschwindigkeit vom Bezugssystem ist dabei nicht (...)
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  6. Run the experiment, publish the study, close the sale: Commercialized biomedical research.Aleta Quinn - 2016 - De Ethica 2 (3):5-21.
    Business models for biomedical research prescribe decentralization due to market selection pressures. I argue that decentralized biomedical research does not match four normative philosophical models of the role of values in science. Non-epistemic values affect the internal stages of for-profit biomedical science. Publication planning, effected by Contract Research Organizations, inhibits mechanisms for transformative criticism. The structure of contracted research precludes attribution of responsibility for foreseeable harm resulting from methodological choices. The effectiveness of business strategies leads to overrepresentation of profit values (...)
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  7.  76
    (1 other version)Auf der Suche nach den Fundamenten des Theismus [In Search of the Foundations of Theism].Philip L. Quinn & Vincent C. Müller - 1998 - In Christoph Jäger (ed.), Analytische Religionsphilosophie. UTB. pp. 331-353.
    Dieser Aufsatz ist eine kritische und erkundende Diskussion von Plantingas Behauptung, daß bestimmte Aussagen, aus denen evidentermaßen folgt, daß Gott existiert, berechtigterweise basal sein könnten. Im kritischen Abschnitt argumentiere ich dafür, daß es Plantinga nicht gelingt zu zeigen, daß das Kriterium des modernen Fundamentalisten für berechtigte Basalität, dem zufolge solche Aussagen nicht berechtigterweise basal sein können, selbstreferentiell inkohärent oder anderweitig mangelhaft ist. Im erkundenden Abschnitt versuche ich, ein Argument für die Auffassung zu entwickeln, daß solche Aussagen, selbst wenn sie berechtigterweise (...)
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  8. Interdisciplinary Higher Education.W. Martin Davies & Marcia Devlin - 2010 - In W. Martin Davies, Marcia Devlin & Malcolm Tight (eds.), Interdisciplinary Higher Education: Perspectives and Practicalities. Bingley, UK: Emerald Publishing. pp. 3-28.
    In higher education, interdisciplinarity involves the design of subjects that offer the opportunity to experience ‘different ways of knowing’ from students’ core or preferred disciplines. Such an education is increasingly important in a global knowledge economy. Many universities have begun to introduce interdisciplinary studies or subjects to meet this perceived need. This chapter explores some of the issues inherent in moves towards interdisciplinary higher education. Definitional issues associated with the term ‘academic discipline’, as well as other terms, including ‘multidisciplinary’, ‘cross-disciplinary’, (...)
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  9. Counteridenticals.Alexander W. Kocurek - 2018 - The Philosophical Review 127 (3):323-369.
    A counteridentical is a counterfactual with an identity statement in the antecedent. While counteridenticals generally seem non-trivial, most semantic theories for counterfactuals, when combined with the necessity of identity and distinctness, attribute vacuous truth conditions to such counterfactuals. In light of this, one could try to save the orthodox theories either by appealing to pragmatics or by denying that the antecedents of alleged counteridenticals really contain identity claims. Or one could reject the orthodox theory of counterfactuals in favor of a (...)
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  10. Generalized Empirical Method in the Biological Sciences.Terrance Quinn - 2014 - Dialogues in Philosophy, Mental and Neuro Sciences 7 (1):31.
    Robert Henman’s article, Can brain scanning and imaging techniques contribute to a theory of thinking? came to my attention recently. My own work over the years has included applications of mathematics in the biological sciences, collaboration in experimental work in biochemistry, as well as work in the philosophy of the biological sciences. Henman suggests something that, at present, would be out of the ordinary.
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  11. Beautiful, Troubling Art: In Defense of Non-Summative Judgment.P. Quinn White - manuscript
    Do the ethical features of an artwork bear on its aesthetic value? This movie endorses misogyny, that song is a civil rights anthem, the clay constituting this statue was extracted with underpaid labor—are facts like these the proper bases for aesthetic evaluation? I argue that this debate has suffered from a false presupposition: that if the answer is yes (for at least some such ethical features), such considerations feature as pro tanto contributions to an artwork's overall aesthetic value, i.e., as (...)
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  12. Nudges, Nudging, and Self-Guidance Under the Influence.W. Jared Parmer - 2023 - Ergo 9 (44):1199-1232.
    Nudging works through dispositions to decide with specific heuristics, and has three component parts. A nudge is a feature of an environment that enables such a disposition; a person is nudged when such a disposition is triggered; and a person performs a nudged action when such a disposition manifests in action. This analysis clarifies an autonomy-based worry about nudging as used in public policy or for private profit: that a person’s ability to reason well is undermined when she is nudged. (...)
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  13. Kant's 'in itself': Toward a New Adverbial Reading.W. Clark Wolf - 2023 - Kant Studien 114 (2):207-246.
    It is commonly assumed that the expression “an sich selbst” (“in itself”) in Kant combines with terms to form complex nouns such as “thing in itself” and “end in itself.” I argue that the basic use of “an sich selbst” in Kant’s German is as a sentence adverb, which has the role of modifying subject-predicate combinations, rather than either subject or predicate on their own. Expressions of the form “S is P an sich selbst” mean roughly that S is P (...)
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  14. Soft Impeachment Disowned.W. V. Quine - 1980 - Pacific Philosophical Quarterly 61 (4):450-451.
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  15. (1 other version)Towards a Philosophy of Financial Technologies.Mark Coeckelbergh, Quinn DuPont & Wessel Reijers - 2017 - Philosophy and Technology:1-6.
    This special issue introduces the study of financial technologies and finance to the field of philosophy of technology, bringing together two different fields that have not traditionally been in dialogue. The included articles are: Digital Art as ‘Monetised Graphics’: Enforcing Intellectual Property on the Blockchain, by Martin Zeilinger; Fundamentals of Algorithmic Markets: Liquidity, Contingency, and the Incomputability of Exchange, by Laura Lotti; ‘Crises of Modernity’ Discourses and the Rise of Financial Technologies in a Contested Mechanized World, by Marinus Ossewaarde; Two (...)
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  16.  69
    Concepts in human adults.Denis Mareschal, Paul Quinn & Stephen Lea - 2010 - In Denis Mareschal, Paul Quinn & Stephen E. G. Lea (eds.), The Making of Human Concepts. Oxford University Press. pp. 18.
    Physics tells us that the world that we live in is “really” composed of vast numbers of tiny particles, defined and individuated by their mass, charge, velocity and position. That is all there is, the rest being empty space. In contrast the world that we interact with in our every day lives is composed of rooms with windows, people and cats, and plates filled with milk and cornflakes. It is a world of individual objects and stuffs, most of which can (...)
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  17. Reflections on Whitman, Dewey, and educational reform: recovering spiritual democracy in our materialistic times.J. Garrison & E. J. O'Quinn - 2004 - Education and Culture 20 (2):68-77.
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  18. Plutarch's Epicurean Justification of Religious Belief.Jason W. Carter - 2018 - Journal of the History of Philosophy 56 (3):385-412.
    In his dialogue, 'Non posse suaviter vivi secundum Epicurum', Plutarch of Chaeronea criticizes Epicurus for not believing that the gods are provident over human affairs and for not believing that our souls survive death. However, Plutarch’s arguments are striking in that they do not offer any theoretical justification for believing either of these religious claims to be true; rather, they aim to establish that we are practically justified in adopting them if we follow Epicurus’s rule that the goal of belief (...)
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  19. Rethinking Hegel's Conceptual Realism.W. Clark Wolf - 2018 - Review of Metaphysics 72 (2):331-70.
    In this paper, I contest increasingly common "realist" interpretations of Hegel's theory of "the concept" (der Begriff), offering instead a "isomorphic" conception of the relation of concepts and the world. The isomorphism recommended, however, is metaphysically deflationary, for I show how Hegel's conception of conceptual form creates a conceptually internal standard for the adequacy of concepts. No "sideways-on" theory of the concept-world relationship is envisioned. This standard of conceptual adequacy is also "graduated" in that it allows for a lack of (...)
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  20. The Myth of the Taken: Why Hegel Is Not a Conceptualist.W. Clark Wolf - 2019 - International Journal of Philosophical Studies 27 (3):399-421.
    ABSTRACTThe close connection often cited between Hegel and Wilfrid Sellars is not only said to lie in their common negative challenges to the ‘framework of givenness,’ but also in the positive less...
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  21. Meaningful Work and Achievement in Increasingly Automated Workplaces.W. Jared Parmer - forthcoming - The Journal of Ethics:1-25.
    As automating technologies are increasingly integrated into workplaces, one concern is that many of the human workers who remain will be relegated to more dull and less positively impactful work. This paper considers two rival theories of meaningful work that might be used to evaluate particular implementations of automation. The first is achievementism, which says that work that culminates in achievements to workers’ credit is especially meaningful; the other is the practice view, which says that work that takes the form (...)
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  22. Uwagi Autora Traktatu Polityczno-Filozoficznego w odpowiedzi na recenzję Katarzyny Haremskiej i notę recenzyjną Pawła Kłoczowskiego.W. Julian Korab-Karpowicz - 2017 - Argument: Biannual Philosophical Journal 7 (1):175-179.
    Tractatus Politico-Philosophicus (Political-Philosophical Treatise) of W. Julian Korab-Karpowicz proposes a new idea-system. Ideas concerning different topics related to politics are introduced. The work aims to establish the principles of good governance and of a happy society, and to open up new directions for the future development of humankind. It is also in part a critique of the epistemology of early Wittgenstein as presented in his Tractatus Logico-Philosophicus. It argues that one can speak about politics and ethics with sense, and that (...)
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  23. Theories and things.W. V. Quine (ed.) - 1981 - Cambridge: Harvard University Press.
    Things and Their Place in Theories Our talk of external things, our very notion of things, is just a conceptual apparatus that helps us to foresee and ...
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  24. (2 other versions)Epistemology Naturalized.W. V. Quine - 1969 - In Willard van Orman Quine (ed.), Ontological Relativity and Other Essays. Columbia University Press.
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  25. From Sensor Variables to Phenomenal Facts.W. Schwarz - 2019 - Journal of Consciousness Studies 26 (9-10):217-227.
    Some cognitive processes appear to have “phenomenal” properties that are directly revealed to the subject and not determined by physical properties. I suggest that the source of this appearance is the method by which our brain processes sensory information. The appearance is an illusion. Nonetheless, we are not mistaken when we judge that people sometimes fee lpain.
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  26. Husserl on the overlap of pure and empirical concepts.W. Clark Wolf - 2020 - European Journal of Philosophy 29 (4):1026-1038.
    European Journal of Philosophy, Volume 29, Issue 4, Page 1026-1038, December 2021.
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  27. An infrastructural account of scientific objectivity for legal contexts and bloodstain pattern analysis.W. John Koolage, Lauren M. Williams & Morgen L. Barroso - 2021 - Science in Context 34 (1):101-119.
    ArgumentIn the United States, scientific knowledge is brought before the courts by way of testimony – the testimony of scientific experts. We argue that this expertise is best understoodfirstas related to the quality of the underlying scienceand thenin terms of who delivers it. Bloodstain pattern analysis (BPA), a contemporary forensic science, serves as the vaulting point for our exploration of objectivity as a metric for the quality of a science in judicial contexts. We argue that BPA fails to meet the (...)
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  28. W.V. Quine, Immanuel Kant Lectures, translated and introduced by H.G. Callaway.H. G. Callaway & W. V. Quine (eds.) - 2003 - Frommann-Holzboog.
    This book is a translation of W.V. Quine's Kant Lectures, given as a series at Stanford University in 1980. It provide a short and useful summary of Quine's philosophy. There are four lectures altogether: I. Prolegomena: Mind and its Place in Nature; II. Endolegomena: From Ostension to Quantification; III. Endolegomena loipa: The forked animal; and IV. Epilegomena: What's It all About? The Kant Lectures have been published to date only in Italian and German translation. The present book is filled out (...)
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  29. DSm Super Vector Space of Refined Labels.W. B. Vasantha Kandasamy & Florentin Smarandache - 2011 - Columbus, OH, USA: Zip Publishing.
    In this book authors for the first time introduce the notion of supermatrices of refined labels. Authors prove super row matrix of refined labels form a group under addition. However super row matrix of refined labels do not form a group under product; it only forms a semigroup under multiplication. In this book super column matrix of refined labels and m × n matrix of refined labels are introduced and studied.
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  30. Linguistic Geometry and its Applications.W. B. Vasantha Kandasamy, K. Ilanthenral & Florentin Smarandache - 2022 - Miami, FL, USA: Global Knowledge.
    The notion of linguistic geometry is defined in this book. It is pertinent to keep in the record that linguistic geometry differs from classical geometry. Many basic or fundamental concepts and notions of classical geometry are not true or extendable in the case of linguistic geometry. Hence, for simple illustration, facts like two distinct points in classical geometry always define a line passing through them; this is generally not true in linguistic geometry. Suppose we have two linguistic points as tall (...)
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  31. Superbimatrices and Their Generalizations.W. B. Vasantha Kandasamy & Florentin Smarandache - 2009 - Slatina, Romania: CuArt.
    The systematic study of supermatrices and super linear algebra has been carried out in 2008. These new algebraic structures find their applications in fuzzy models, Leontief economic models and data-storage in computers.
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  32. (1 other version)I.W.Kelly Logical consistency and the child.I. W. Kelly - 1981 - Philosophy of the Social Sciences 11 (March):15-18.
    The Swiss psychologist Jean Piaget contends that children below the age of 12 see no necessity for the logical law of non-contradiction. I argue this view is problematic. First of all, Piaget's dialogues with children which are considered supportive of this position are not clearly so. Secondly, Piaget underestimates the necessary nature of following the logical law of non-contradiction in everyday discourse. The mere possibility of saying something significant and informative at all presupposes that the law of non-contradiction is enforced.
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  33. Kant's Formula of Universal Law as a Test of Causality.W. Clark Wolf - 2023 - Philosophical Review 132 (3):459-90.
    Kant’s formula of universal law (FUL) is standardly understood as a test of the moral permissibility of an agent’s maxim: maxims which pass the test are morally neutral, and so permissible, while those which do not are morally impermissible. In contrast, I argue that the FUL tests whether a maxim is the cause or determining ground of an action at all. According to Kant’s general account of causality, nothing can be a cause of some effect unless there is a law-like (...)
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  34. Linguistic Functions.W. B. Vasantha Kandasamy, K. Ilanthenral & Florentin Smarandache - 2022 - Miami, FL, USA: Global Knowledge.
    In this book, for the first time, authors try to introduce the concept of linguistic variables as a continuum of linguistic terms/elements/words in par or similar to a real continuum. For instance, we have the linguistic variable, say the heights of people, then we place the heights in the linguistic continuum [shortest, tallest] unlike the real continuum (–∞, ∞) where both –∞ or +∞ is only a non-included symbols of the real continuum, but in case of the linguistic continuum we (...)
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  35. Linguistic Matrices.W. B. Vasantha Kandasamy, K. Ilanthenral & Florentin Smarandache - 2022 - Miami, FL, USA: Global Knowledge.
    In this book, the authors introduce the linguistic set associated with a linguistic variable and the structure of matrices, which they define as linguistic matrices. The authors build linguistic matrices only for those linguistic variables which yield a linguistic continuum or an ordered linguistic set. This book is organised into three chapters. The first chapter is introductory, in which we introduce all the basic concepts of linguistic variables and the associated linguistic set to make this book self-contained. Chapter two introduces (...)
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  36. Special Subset Linguistic Topological Spaces.W. B. Vasantha Kandasamy, Ilanthenral K. & Florentin Smarandache - 2023 - Infinite Study.
    In this book, authors, for the first time, introduce the new notion of special subset linguistic topological spaces using linguistic square matrices. This book is organized into three chapters. Chapter One supplies the reader with the concept of ling set, ling variable, ling continuum, etc. Specific basic linguistic algebraic structures, like linguistic semigroup linguistic monoid, are introduced. Also, algebraic structures to linguistic square matrices are defined and described with examples. For the first time, non-commutative linguistic topological spaces are introduced. The (...)
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  37. Algebraic Structures using Super Interval Matrices.W. B. Vasantha Kandasamy & Florentin Smarandache - 2011 - Columbus, OH, USA: Educational Publisher.
    In this book authors for the first time introduce the notion of super interval matrices using special intervals. The advantage of using super interval matrices is that one can build only one vector space using m × n interval matrices, but in case of super interval matrices we can have several such spaces depending on the partition on the interval matrix.
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  38. Super Special Codes using Super Matrices.W. B. Vasantha Kandasamy, Florentin Smarandache & K. Ilanthenral - 2010 - Stockholm, Sweden: Svenska fysikarkivet.
    The new classes of super special codes are constructed in this book using the specially constructed super special vector spaces. These codes mainly use the super matrices. These codes can be realized as a special type of concatenated codes.
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  39. (1 other version)The Authority of Conceptual Analysis in Hegelian Ethical Life.W. Clark Wolf - 2020 - In Jiří Chotaš & Tereza Matějčková (eds.), An Ethical Modernity?: Hegel’s Concept of Ethical Life Today. Boston: BRILL. pp. 15-35.
    While the idea of philosophy as conceptual analysis has attracted many adherents and undergone a number of variations, in general it suffers from an authority problem with two dimensions. First, it is unclear why the analysis of a concept should have objective authority: why explicating what we mean should express how things are. Second, conceptual analysis seems to lack intersubjective authority: why philosophical analysis should apply to more than a parochial group of individuals. I argue that Hegel’s conception of social (...)
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  40. Metaphysics Supervenes on Logic: The Role of the Logical Forms in Hegel's "Replacement" of Metaphysics.W. Clark Wolf - 2021 - Journal of the History of Philosophy 59 (2):271-298.
    Hegel often says that his "logic" is meant to replace metaphysics. Since Hegel's Science of Logic is so different from a standard logic, most commentators have not treated the portion of that work devoted to logical forms as relevant to this claim. This paper argues that Hegel's discussion of logical forms of judgment and syllogism is meant to be the foundation of his reformation of metaphysics. Implicit in Hegel's discussion of the logical forms is the view that the metaphysical concepts (...)
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  41. The Weakness of the Law: The Opposition of Concept and Life in Hegel’s Early Ethics.W. Clark Wolf - 2017 - In Evangelia Sembou (ed.), The Young Hegel and Religion. Oxford: Peter Lang. pp. 142-72.
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  42. Kant's Conclusions in the Transcendental Aesthetic.W. Clark Wolf - forthcoming - Journal of the History of Philosophy.
    In the Transcendental Aesthetic (TA), Kant is typically held to make negative assertations about “things in themselves,” namely that they are not spatial or temporal. These negative assertions stand behind the “neglected alternative” problem for Kant’s transcendental idealism. According to this problem, Kant may be entitled to assert that spatio-temporality is a subjective element of our cognition, but he cannot rule out that it may also be a feature of the objective world. In this paper, I show in a new (...)
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  43. Explanatoriness is evidentially irrelevant, or inference to the best explanation meets Bayesian confirmation theory.W. Roche & E. Sober - 2013 - Analysis 73 (4):659-668.
    In the world of philosophy of science, the dominant theory of confirmation is Bayesian. In the wider philosophical world, the idea of inference to the best explanation exerts a considerable influence. Here we place the two worlds in collision, using Bayesian confirmation theory to argue that explanatoriness is evidentially irrelevant.
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  44. “L'ètica de la creença” (W. K. Clifford) & “La voluntat de creure” (William James).Alberto Oya, William James & W. K. Clifford - 2016 - Quaderns de Filosofia 3 (2):123-172.
    Catalan translation, introductory study and notes on W. K. Clifford’s “The Ethics of Belief”. Published in Clifford, W.K. “L’ètica de la creença”. Quaderns de Filosofia, vol. III, n. 2 (2016), pp. 129–150. // Catalan translation, introductory study and notes on William James’s “The Will to Believe”. Published in James, William. “La voluntat de creure”. Quaderns de Filosofia, vol. III, n. 2 (2016), pp. 151–172. [Introductory study published in Oya, Alberto. “Introducció. El debat entre W. K. Clifford i William James”. Quaderns (...)
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  45. Imperative Inference and Practical Rationality.Daniel W. Harris - 2021 - Philosophical Studies (4):1065-1090.
    Some arguments include imperative clauses. For example: ‘Buy me a drink; you can’t buy me that drink unless you go to the bar; so, go to the bar!’ How should we build a logic that predicts which of these arguments are good? Because imperatives aren’t truth apt and so don’t stand in relations of truth preservation, this technical question gives rise to a foundational one: What would be the subject matter of this logic? I argue that declaratives are used to (...)
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  46. Proportionality, Determinate Intervention Effects, and High-Level Causation.W. Fang & Zhang Jiji - forthcoming - Erkenntnis.
    Stephen Yablo’s notion of proportionality, despite controversies surrounding it, has played a significant role in philosophical discussions of mental causation and of high-level causation more generally. In particular, it is invoked in James Woodward’s interventionist account of high-level causation and explanation, and is implicit in a novel approach to constructing variables for causal modeling in the machine learning literature, known as causal feature learning (CFL). In this article, we articulate an account of proportionality inspired by both Yablo’s account of proportionality (...)
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  47. Critical Thinking in Business Education: Current Outlook and Future Prospects.W. Martin Davies & Angelito Calma - forthcoming - Studies in Higher Education.
    This study investigates all available literature related to critical thinking in business education in a survey of publications in the field produced from 1990-2019. It conducts a thematic analysis of 787 articles found in Web of Science and Google Scholar, including a specific focus on 55 highly-cited articles. The aim is to investigate the importance of critical thinking in business education, how it is conceptualised in business education research, the business contexts in which critical thinking is situated, and the key (...)
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  48. The Flawed Scientific Basis of the Altered Nuclear Transfer-Oocyte Assisted Reprogramming (ANT-OAR) Proposal.W. Malcolm Byrnes - 2007 - Stem Cell Reviews and Reports 1 (3):60-65.
    First put forth in June 2005, the altered nuclear transfer-oocyte assisted reprogramming (ANT-OAR) proposal has been promoted as an ethically-acceptable alternative to the embryo-destructive methods now used to obtain embryonic stem cells. According to its proponents, the goal of ANT-OAR is to use the cloning process to create a pluripotent stem cell. This would be achieved through overexpression of the transcription factor Nanog (or a hypothetical substitute) both in the enucleated egg cell and in the somatic cell prior to transfer (...)
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  49. The Structural Basis for Kinetic and Allosteric Differences between Two Bacterial Phosphofructokinases.W. Malcolm Byrnes - 1994 - Dissertation,
    The fructose 6-phosphate (Fru-6P) saturation curve for phosphofructokinase (PFK) from E. coli is sigmoidal in the presence of saturating MgATP levels, while the corresponding curve for B. stearothermophilus PFK is essentially hyperbolic. Sigmoidality can be due to apparent cooperativity arising from the kinetic mechanism of an enzyme. We have determined the kinetic mechanism of B. stearothermophilus PFK (BsPFK). BsPFK was found to obey a non rapid-equilibrium random mechanism similar to the one E. coli PFK (EcPFK) follows. Substrate inhibition by MgATP (...)
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  50. (1 other version)Design Principles as Minimal Models.W. Fang - 2024 - Studies in History and Philosophy of Science 105:50-58.
    In this essay I suggest that we view design principles in systems biology as minimal models, for a design principle usually exhibits universal behaviors that are common to a whole range of heterogeneous (living and nonliving) systems with different underlying mechanisms. A well-known design principle in systems biology, integral feedback control, is discussed, showing that it satisfies all the conditions for a model to be a minimal model. This approach has significant philosophical implications: it not only accounts for how design (...)
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