It is now the majority view amongst philosophers and theologians that any world could have been better. This places the choice of which world to create into an especially challenging class of decision problems: those that are discontinuous in the limit. I argue that combining some weak, plausible norms governing this type of problem with a creator who has the attributes of the god of classical theism results in a paradox: no world is possible. After exploring some ways out of (...) the paradox, I conclude that the classical theist should accept Marilyn Adams’s view that no norms apply to gods. (shrink)

There is no doubt that custard apple diseases are among the important reasons that destroy the Custard Apple plant and its agricultural crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases is a good step to provide the appropriate and correct treatment. Determining the treatment with high accuracy depends on the method used to correctly diagnose the disease, expert systems can greatly help in avoiding damage to these plants. The expert system (...) correctly diagnoses Custard Apple disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: A specialized syllable language system was established for the diagnosis of Custard Apple plant disease. (shrink)

Abstract: In this study, we explore the challenge of identifying and preventing diseases in apple trees, which is a popular activity but can be difficult due to the susceptibility of these trees to various diseases. To address this challenge, we propose the use of Convolutional Neural Networks, which have proven effective in automatically detecting plant diseases. To validate our approach, we use images of apple leaves, including Apple Rot Leaves, Leaf Blotch, Healthy Leaves, and Scab Leaves collected (...) from Kaggle which is part from the Plant Village dataset. We generate a comprehensive training dataset using techniques such as image filtering, compression, and generation. Our model achieves impressive accuracy scores for all classes, with an overall accuracy of 99.93% on a dataset of 10,000 labeled images . (shrink)

I want to distinguish between maxims at three levels of abstraction. At the first level are what I shall call individual maxims, or i‐maxims: maxim tokens as adopted by particular rational beings. At the second level are abstract maxims, or a‐maxims: abstract principles distinct from any individual who adopts them. At the third level are maxim kinds, or k‐maxims: sets of various action‐guiding principles that are grouped on the basis of their content. In this paper, I argue for the thesis (...) that i‐maxims are the locus of assessment in Kant's ethics. (shrink)

This is an etymological, Biblical and philosophical scrutiny of Milton's Satan. While Satan is a metaphor in Paradise Lost, he is very much real within Christian Studies. This essay revisits the reality of Satan.

Consumers often buy products not because of their attributes per se but rather because of the ultimate benefits that these attributes provide, in turn leading to the satisfaction of ultimate values. And Apple is a type of company which understand their customers & future aspects of innovation in a way that no other companies do. That’s the reason that apple is at No. 1 place in Top 50 Most innovative companies. This article endeavors to recognize the consumer perception (...) towards the Apple products and what is Apple’s ideology. In this article the researcher has listed down 12 variables which affect the consumer behavior most while purchasing Apple products. (shrink)

How can we have a sense of the presence of ordinary three-dimensional objects (e.g., an apple on my desk, a partially occluded cat behind a picket fence) when we are only presented with some parts of objects perceived from a particular egocentric viewpoint (e.g., the facing side of the apple, the unoccluded parts of the cat)? This paper presents and defends a novel answer to this question by incorporating insights from two prominent contemporary theories of perception, naïve realism (...) and sensorimotor theory. Naïve realism is the view that perception is fundamentally a matter of obtaining a relation of ‘acquaintance’ with some mind-independent entities (e.g., objects, properties, events). Sensorimotor theory holds that perception involves implicit practical understanding or ‘anticipation’ of the covariance between movements and sensory changes. I argue that perceptual presence is best accounted for in terms of the combination of our direct ‘acquaintance’ with some parts of perceived objects and sensorimotor ‘anticipations’ of how the objects would look different depending on some movements and actions. (shrink)

Abstract: Fruits are a rich source of energy, minerals and vitamins. They also contain fiber. There are many fruits types such as: Apple and pears, Citrus, Stone fruit, Tropical and exotic, Berries, Melons, Tomatoes and avocado. Classification of fruits can be used in many applications, whether industrial or in agriculture or services, for example, it can help the cashier in the hyper mall to determine the price and type of fruit and also may help some people to determining whether (...) a certain type of fruit meets their nutritional requirement. In this paper, machine learning based approach is presented for classifying and identifying 10 different fruit with a dataset that contains 6847 images use 4793 images for training, 1027 images for validation and 1027 images for testing. A deep learning technique that extensively applied to image recognition was used. We used 70% from image for training and 15% from image for validation 15% for testing. Our trained model achieved an accuracy of 100% on a held-out test set, demonstrating the feasibility of this approach. (shrink)

Do we (sometimes) perceive apples as edible? One could argue that it is just a manner of speaking to say so: we do not really see an object as edible, we see it as having certain shape, size and color and we only infer on the basis of these properties that it is. I argue that we do indeed see objects as edible, and do not just believe that they are. My argument proceeds in two steps. First, I point out (...) that Susanna Siegel's influential argument in favor of the claim that we represent sortal properties perceptually does not work. Second, I argue that we can fix this argument if we replace the sortal property in question with the property of being edible, climbable or Q-able in general. (shrink)

Compelling voices charge that the theological notion of “sacrifice” valorizes suffering and fosters a culture of violence by the claim that Christ’s death on the Cross paid for human sins. Beneath the ‘sacred’ violence of sacrifice, René Girard discerns a concealed scapegoat-murder driven by a distortion of human desire that itself must lead to human self-annihilation. I here ask: can one speak safely of sacrifice; and can human beings somehow cease to practice the sacrifice that must otherwise destroy them? Drawing (...) on Gregory the Great (ca. 540–604), I propose an understanding of sacrifice that both distinguishes Christian sacrifice from sacred violence and accounts for how to overcome the roots of the sacred violence identified by Girard. I make four claims: First, Girard recognizes two kinds of sacrifice—one, the scapegoat murder, overcomes community rivalries by unanimous imitation of an accuser, shifting blame onto a third party who is collectively murdered; the other sort of sacrifice practices renunciation and forgiveness in imitation of God. These I respectively designate the “Satanic” (Girard’s term) and the “theomimetic” (mine). Second, I analyze the intrinsic instability that keeps the Satanic from sustaining the societal order and unity that it promises. Third, by a constructive reading of Gregory the Great, I posit that satanic sacrifice overlooks and indeed exacerbates the root of human covetousness—a failure to love. Fourth, Gregory’s teaching on the imitation of Christ enables us to expand on Girard’s account of the theo¬mimetic sacrifice of renunciation, to clarify how this latter might not only oppose but also systematically subvert the Satanic by healing the disorder out of which mimetic rivalry and scapegoating first take their rise. (shrink)

To what extent should teachers promote the view from nowhere as an ideal to strive for in education? To address this question, I will use Mark Twain’s The Mysterious Stranger as an example, illustrating the stakes involved when the view from nowhere is taken to be an attainable educational ideal. I will begin this essay by offering a description of Thomas Nagel’s view from nowhere. Having done this, I will return to Twain’s story, providing some further examples of how access (...) to the view from nowhere comes to influence the educational process in different ways. I will then connect the educational question raised by Twain’s story to two radically different versions of the exemplar found in the works of Benedict de Spinoza: the philosopher and the prophet. These figures will help illustrate how the striving for philosophical truth can sometimes be educationally inapt, as education always needs to account for humans being human, all too human. (shrink)

Consumers often buy products not because of their attributes per se but rather because of the ultimate benefits that these attributes provide, in turn leading to the satisfaction of ultimate values. And Apple is a type of company which understand their customers & future aspects of innovation in a way that no other companies do. That’s the reason that apple is at No. 1 place in Top 50 Most innovative companies. This article endeavors to recognize the consumer perception (...) towards the Apple products and what is Apple’s ideology. In this article the researcher has listed down 12 variables which affect the consumer behavior most while purchasing Apple products. The researcher took 50 sample sizes to make this paper and this study is being done in Tiruchirappalli District. To prepare the factors, I have used Factor analysis test. (shrink)

The computational genomics community has come increasingly to rely on the methodology of creating annotations of scientific literature using terms from controlled structured vocabularies such as the Gene Ontology (GO). We here address the question of what such annotations signify and of how they are created by working biologists. Our goal is to promote a better understanding of how the results of experiments are captured in annotations in the hope that this will lead to better representations of biological reality through (...) both the annotation process and ontology development, and in more informed use of the GO resources by experimental scientists. (shrink)

Consumers often buy products not because of their attributes per se but rather because of the ultimate benefits that these attributes provide, in turn leading to the satisfaction of ultimate values. And Apple is a type of company which understand their customers & future aspects of innovation in a way that no other companies do. That’s the reason that apple is at No. 1 place in Top 50 Most innovative companies. This article endeavors to recognize the consumer perception (...) towards the Apple products and what is Apple’s ideology. In this article the researcher has listed down 12 variables which affect the consumer behavior most while purchasing Apple products. The researcher took 50 sample sizes to make this paper and this study is being done in Tiruchirappalli District. To prepare the factors, I have used Factor analysis test. (shrink)

This article endeavors to recognize the consumer perception towards the Apple products and what is Apple’s ideology. In this article the researcher has listed down 12 variables which affect the consumer behavior most while purchasing Apple products. The researcher took 50 sample sizes to make this paper and this study is being done in Tiruchirappalli District. To prepare the factors, I have used Factor analysis test.

Consumers often buy products not because of their attributes per se but rather because of the ultimate benefits that these attributes provide, in turn leading to the satisfaction of ultimate values. And Apple is a type of company which understand their customers & future aspects of innovation in a way that no other companies do. That’s the reason that apple is at No. 1 place in Top 50 Most innovative companies. This article endeavors to recognize the consumer perception (...) towards the Apple products and what is Apple’s ideology. In this article the researcher has listed down 12 variables which affect the consumer behavior most while purchasing Apple products. The researcher took 50 sample sizes to make this paper and this study is being done in Tiruchirappalli District. To prepare the factors, I have used Factor analysis test. (shrink)

In his eleventh century dialogue De Casu Diaboli, Anselm seeks to avoid the problem of evil for theodicy and explain the fall of Satan as attributable to Satan’s own self-creating wrongful will. It is something, as such, for which God as Satan’s divine Creator cannot be held causally or morally responsible. The distinctions on which Anselm relies presuppose an interesting metaphysics of nonbeing, and of the nonbeing of evil in particular as a privation of good, worthy of critical philosophical investigation (...) in its own right. Anselm’s concept of nonbeing does not resolve the philosophical problem of evil implied by Satan’s fall from grace, but is shown perhaps more unexpectedly to enable Anselm’s proof for the inconceivable nonexistence of God as the greatest conceivable intended object of thought to avoid Kant’s Critique of Pure Reason objection to the general category of ”ontological’ arguments. (shrink)

In the first part of this paper we will consider the likely extent of Spinoza’s exposure to Kabbalistic literature as he was growing up in Amsterdam. In the second part we will closely study several texts in which Spinoza seems to engage with Kabbalistic doctrines. In the third and final part we will study the role of the two crucial doctrines of emanation and pantheism (or panentheism), in Spinoza’s system and in the Kabbalistic literature.

In this paper, I assess John McDowell's paper "Avoiding the Myth of the Given" (2009) (AMG) and its theory of epistemological openness to the world. I trace its motivations back to Kantian, Sellarsian and Aristotelean roots. I argue that McDowell subscribes to a kind of Holistic Theory of Rationality (HTR). To explain the HTR, I will analyze the Sellarsian notions of the "Manifest Image," the "Myth of the Given" and the "logical space of reasons." I argue that the holistic nature (...) of McDowell's theory gives it particular properties that put it in need of conservatism, because all the elements of the theory "hang together" - i.e. cohere - in a dangerous fashion. I argue that McDowell cannot afford big changes without upsetting the apple-cart. With this in mind, I shall assess the merits and demerits of AMG, and its modified theory of perceptual content, as an attempted conservative reform of HTR. I want to argue that, taken independently, AMG is a good and important change, but taken holistically it is non-conservative, and disruptive, of the McDowellian picture. Thus, if we wish to proceed with the McDowellian path, we are led to a choice between rejecting the local reform (and retreating back to an earlier version) or demanding further explanations of its global implications. (shrink)

The World’s Leading Research and Development Institutions and Companies -/- Introduction -/- Research and Development (R&D) is the backbone of global innovation, driving technological progress, economic growth, and scientific discoveries. Across the world, top institutions and corporations invest billions of dollars into R&D to push the boundaries of human knowledge and create groundbreaking technologies. This essay explores the most influential research institutions and companies shaping the future through their contributions in science, engineering, medicine, and technology. -/- The Role of Research (...) Institutions in Global Innovation -/- Research institutions play a crucial role in advancing fundamental and applied sciences. Many of these institutions are publicly funded universities and government research agencies that focus on a wide range of disciplines, from medicine and engineering to artificial intelligence and space exploration. -/- 1. Leading Research Institutions -/- Some of the most prestigious research institutions include: -/- National Institutes of Health (NIH) – USA: The primary agency of the U.S. government responsible for biomedical and public health research. -/- National Aeronautics and Space Administration (NASA) – USA: A global leader in aerospace and space exploration, NASA continues to innovate in space technology and planetary science. -/- Centre National de la Recherche Scientifique (CNRS) – France: The largest governmental research organization in France, covering all scientific disciplines. -/- Max Planck Society – Germany: A network of research institutes in Germany, known for excellence in science and technology. -/- Chinese Academy of Sciences (CAS) – China: China’s premier research institution focuses on science and technology innovation across various fields. -/- Harvard University – USA: Leads in biomedical research, social sciences, and humanities. -/- Massachusetts Institute of Technology (MIT) – USA: At the forefront of engineering, robotics, artificial intelligence, and quantum computing research. -/- Stanford University – USA: Known for its deep ties to Silicon Valley, Stanford plays a key role in tech innovation. -/- University of Oxford & University of Cambridge – UK: Both institutions are among the oldest and most respected in the world, conducting high-impact research in medicine, engineering, and the humanities. -/- Swiss Federal Institute of Technology Zurich (ETH Zurich) – Switzerland: Excels in engineering and natural sciences research. -/- University of Tokyo – Japan: Japan’s leading university, known for its research in science and technology. -/- California Institute of Technology (Caltech) – USA: A leader in space science and physics. -/- Imperial College London – UK: Specializes in engineering, medical, and business research. -/- University of Toronto – Canada: A top institution in AI, robotics, and engineering. -/- 2. Engineering and Technology Research Leaders -/- Engineering research institutions contribute to infrastructure, automation, and digital transformation. Some of the most prominent ones include: -/- University of California, Berkeley – USA: Known for its research in engineering, computer science, and environmental science. -/- University of Pennsylvania – USA: Invests in innovative engineering projects. -/- University of Michigan – USA: Known for technological advancements in multiple fields. -/- Swiss Federal Institute of Technology Lausanne (EPFL) – Switzerland: Excels in engineering and digital research. -/- Tsinghua University – China: A leader in AI, renewable energy, and industrial automation research. -/- The Role of Private Companies in Research and Development -/- Private corporations play a major role in R&D, investing heavily in emerging technologies, pharmaceuticals, consumer electronics, and industrial innovations. Many of the world’s biggest companies spend billions to maintain leadership in their respective fields. -/- 1. Leading Technology Companies in R&D -/- Amazon ($73.2B in R&D spending, 2022): Focuses on cloud computing, AI, logistics, and automation. -/- Alphabet (Google) ($39.5B in R&D, 2022): Invests in AI, quantum computing, and search algorithms. -/- Meta (Facebook) ($35.3B in R&D, 2022): Focuses on AI, VR, and the Metaverse. -/- Apple ($27.7B in R&D, 2022): Leads in consumer electronics and semiconductor technology. -/- Microsoft ($26.6B in R&D, 2022): Invests in AI, cloud computing, and software innovation. -/- 2. Engineering and Industrial Companies in R&D -/- Volkswagen ($19.88B in R&D, 2022): A leader in automotive engineering and electric vehicles. -/- Samsung ($19.29B in R&D, 2022): Develops advanced semiconductors and electronics. -/- Intel ($17.53B in R&D, 2022): Focuses on microprocessors and AI hardware. -/- Huawei ($24B in R&D, 2022): Leads in telecommunications and 5G development. -/- Siemens – Germany: A global leader in industrial automation, medical technology, and smart infrastructure. -/- Nokia – Finland: Focuses on telecommunications infrastructure and technology development. -/- Sony – Japan: Invests in consumer electronics, gaming, and entertainment technologies. -/- Boeing – USA: Develops aerospace technology, defense systems, and commercial aircraft innovations. -/- General Electric (GE) – USA: Focuses on energy, aviation, and industrial automation R&D. -/- 3. Pharmaceutical and Biotech Research Leaders -/- Roche ($14.72B in R&D, 2022): A leading pharmaceutical company specializing in diagnostics and biotech innovations. -/- Pfizer: Known for vaccine development, including the COVID-19 vaccine. -/- Moderna: A pioneer in mRNA technology for medical treatments. -/- Johnson & Johnson: Invests heavily in medical devices and pharmaceuticals. -/- Bristol-Myers Squibb – USA: Focuses on biopharmaceutical research, including immunology and oncology. -/- AstraZeneca – UK/Sweden: Invests in pharmaceutical research, particularly in oncology and cardiovascular diseases. -/- The Impact of R&D on Society and the Future -/- The advancements driven by R&D have a profound impact on global society. Some of the most significant areas of innovation include: -/- Healthcare: Research in biotechnology, gene therapy, and medical AI is revolutionizing healthcare, leading to personalized medicine and new treatments for previously incurable diseases. -/- Artificial Intelligence: AI research in institutions and companies is driving automation, machine learning, and deep learning applications. -/- Sustainable Energy: Engineering research is focusing on renewable energy, electric vehicles, and smart grid technologies to combat climate change. -/- Space Exploration: Organizations like NASA, SpaceX, and ESA are expanding human exploration beyond Earth. -/- Telecommunications: Companies like Huawei, Nokia, and Qualcomm are leading the development of 5G and future wireless communication technologies. -/- Automotive Industry: Electric vehicles, hydrogen fuel cells, and autonomous driving are key research areas for companies like Tesla, Volkswagen, and Toyota. -/- Conclusion -/- The world’s leading R&D institutions and companies are shaping the future through their groundbreaking work in science, engineering, medicine, and technology. Universities and research centers provide the foundation for discovery, while corporations drive commercial applications of these innovations. As investments in R&D continue to grow, humanity will witness even greater advancements in fields such as artificial intelligence, biotechnology, and space exploration, ultimately improving lives and pushing the boundaries of what is possible. -/- . (shrink)

This study is a theoretical work in the field of sociology of religion which aims to explain the origin of the act of sin and the fundamental motives of crime and deviation tendencies in this context, from Adam’s story in the Qur'an, the main source of Islam. Sin is regarded as a negative act in religious-cultural sense where one struggles for life and tries to protect itself. Though a direct correlation cannot be established with belief values, the sense of sin (...) can be effective in shaping our everyday life and controlling our behavior. Adam’s story is worthy of examination in this context as it carries the qualification of being a religious text that allows us to study the nature of sin. This is based on the Qur'anic text which we think is the simplest form of expression. Adam and Eve, Satan, Abel and Cain are the actors of this story and prototypes helping us to analyze the nature of sin. In this sense, sin acts in the form of various crimes and deviance behaviors as the result of man's eternity of property, power and status struggle in the person of these prototypes. Some theories which have been put forward about crimes and deviations can give a certain explanation on the subject. Also there is the possibility of giving more comprehensive factual explanations about the act of sin which contains a great deal of crime and deviant behavior, moving from the story of Adam. (shrink)

[This download contains the table of contents and Chapter 1]. I argue here that the claim that conscious states are private, in the sense that only one person can ever experience them directly, is false. There actually is a way to connect the brains of two people that would allow one to have direct experience of the other's conscious, e.g., perceptual states. This would allow, for instance, one person to see that the other had deviant color perception (which was masked (...) by correct linguistic practice). This could be achieved by connecting one person's set of executive processes (or cognitive control network) to the conscious perceptual states of the other. Chapter 5 contains an internalist physicalist account of color according to which colors exist only as brain states. Their function is to enable more precise causal interactions between the executive processes and the brain's perceptual systems. This in turn allows for more precise action: I can select the red apples and leave the green ones. (shrink)

This article engages critically and constructively with Dietrich Bonhoeffer’s biblical study ‘Temptation’ (1938). His study does not always do justice to the text of the New Testament or the theodicean and hamartiological issues pertaining to temptation. And his position that biblically temptation is not the testing of strength, but rather the loss of all strength and defenceless deliverance into Satan’s hands, is hard to defend. However, Bonhoeffer’s idea of Christ-reality undergirds his suggestion that all persons can find in Christ participation, (...) help, and grace in resisting temptation. Bonhoeffer’s most important insight, which requires some unpacking, is that ‘my temptation is nothing other than the temptation of Jesus Christ in me.’. (shrink)

In this note I present a solution to Kripkenstein’s paradox, based on a very simple argument: (1) natural language and rule-following are empirical phenomena; (2) no case has been described, in real life, of a person who behaves as Wittgenstein’s or Kripke’s fictional character; (3) therefore, the discussion of such a case is completely devoid of interest. I lay out the example of a ‘Kripkensteinian apple’, which has a normal weight on even days and is weightless on odd days, (...) in order to highlight the contrast between a genuinely empirical perspective, such as that of physics, and the logical-analytical perspective, under which Kripkenstein’s paradox has attracted so much attention. (shrink)

My first section considers Walter J. Ong’s influential analyses of the logical method of Peter Ramus, on whose system Milton based his Art of Logic. The upshot of Ong’s work is that philosophical logic has become a kind monarch over all other discourses, the allegedly timeless and universal method of mapping and diagramming all concepts. To show how Milton nevertheless resists this tyrannical result in his non-Logic writings, my second section offers new readings of Milton’s poems Il Penseroso and Sonnet (...) 16: “On His Blindness”, along with his prose epilogue to his elegies (and thereby the entire collection entitled Poems). These readings attempt to show (1) the original admixing of philosophy and poetry (under the heading of “thoughtfulness”), (2) the shadow-hidden superiority of poetry in connection to the effeminising disability of blindness, and (3) the potential irony of an apology that arguably suggests poetry’s superiority to philosophy. Finally, I rest my case for Milton’s rebellion by offering an interpretation of Paradise Lost which affirms the character of Satan qua dark, queer, poetic figure of classical republicanism. (shrink)

In Paradise Lost, Satan’s first sight of Eve in Eden renders him “Stupidly good”: his state is one of admirable yet inarticulate responsiveness to reasons. Turning from fiction to real life, I argue that this is an important moral phenomenon, but one that has limits. The essay examines three questions about the relation between having a reason and saying what it is – between normativity and articulacy. Is it possible to have and respond to morally relevant reasons without being able (...) to articulate them? Can moral inarticulacy be good, and if so, what is the value of moral articulacy? And thirdly, can moral philosophy help us to be good? I argue that morality has an inarticulacy-accepting part, an articulacy-encouraging part, an articulacy-surpassing part and an articulacy-discouraging part. Along the way, an account is proposed of what it is to respond to the reasons that make up the substance of morality. (shrink)

The Enigma of Consciousness: Exploring Theories and Angelito Malicse’s Universal Law of Balance -/- Consciousness—the subjective experience of being aware—remains one of humanity’s most profound mysteries. From the vivid redness of an apple to the sting of a scraped knee, our inner world defies easy explanation. Scientists, philosophers, and thinkers have proposed countless theories to unravel its nature, ranging from brain-based models to cosmic speculations. While no definitive count exists, the sheer diversity of ideas reflects both the complexity of (...) consciousness and our relentless curiosity about it. Among these, lesser-known perspectives like Angelito Malicse’s “Universal Law of Balance” offer fresh lenses, suggesting consciousness emerges from equilibrium across natural systems. This essay explores the major theoretical camps of consciousness and delves into Malicse’s unique contribution, weaving together a tapestry of thought that spans the physical, philosophical, and universal. -/- Theories of consciousness often begin with materialist views, which anchor awareness in the physical brain. Integrated Information Theory (IIT), proposed by Giulio Tononi, posits that consciousness arises from the integration of information within a system, measurable as “phi”—a marker of how interconnected and differentiated a network is. Similarly, Bernard Baars’ Global Workspace Theory (GWT) likens consciousness to a theater stage, where information is broadcast to various cognitive processes for attention and action. Neural Correlates of Consciousness (NCC), pursued by Christof Koch and others, seeks specific brain activities tied to experience, while Higher-Order Thought (HOT) theories argue consciousness requires thoughts about thoughts, as David Rosenthal suggests. These models share a belief that consciousness is a product of neural machinery, yet they diverge on how and why subjective experience emerges. -/- Beyond materialism, dualist theories propose that consciousness transcends the physical. René Descartes’ substance dualism famously separated mind and body into distinct realms, a view echoed in modern property dualism, where thinkers like David Chalmers argue physical systems possess non-physical qualities. Panpsychism takes this further, asserting consciousness is fundamental to all matter. Proponents like Philip Goff suggest even electrons might harbor proto-awareness, culminating in human experience through complexity. Quantum theories, such as Roger Penrose and Stuart Hameroff’s Orchestrated Objective Reduction (Orch-OR), link consciousness to quantum processes in microtubules, blending physics with metaphysics. Meanwhile, mysterians like Colin McGinn contend that consciousness might forever elude our grasp, a puzzle beyond human cognition. -/- Into this rich landscape steps Angelito Malicse with his “Universal Law of Balance,” a theory that frames consciousness as an emergent property of equilibrium. Malicse argues that all natural systems—stars, cells, brains—operate under a principle of balance. Inanimate objects like planets achieve this passively through forces like gravity, but living systems actively self-regulate via processes like homeostasis. Consciousness, he proposes, emerges when this self-regulation becomes sufficiently complex, integrating sensory feedback and adaptive responses into a unified awareness. Subjective experiences, or qualia, serve a functional role: pain signals imbalance (e.g., injury), while pleasure reinforces stability (e.g., nourishment). For Malicse, the brain is a dynamic system where neural activity and awareness form a feedback loop, maintaining equilibrium to produce coherent thought. -/- Malicse’s theory extends beyond biology, suggesting any system—artificial or cosmic—could achieve consciousness if it attains balanced self-regulation. Advanced AI, for instance, might mirror the brain’s equilibrium, while the universe itself could exhibit awareness if its vast systems align harmoniously. This echoes panpsychism but roots consciousness in a testable principle rather than inherent universality. Rejecting strict dualism and pure materialism, Malicse sees consciousness as neither wholly separate from nor reducible to physical processes—it’s the interplay of systems in balance. Some interpretations hint at quantum coherence playing a role, akin to Orch-OR, yet balanced with classical neural dynamics. Though less prominent than mainstream theories, Malicse’s view offers a unifying bridge across disciplines. -/- The sheer number of consciousness theories—dozens of major frameworks and hundreds of variants—underscores its elusive nature. A 2021 Nature Reviews Neuroscience paper cataloged over 20 neuroscientific models alone, a fraction of the broader philosophical and interdisciplinary spectrum. From IIT’s mathematical rigor to Malicse’s equilibrium hypothesis, each theory grapples with the “hard problem”—why subjective experience exists at all. While materialists seek answers in neurons, panpsychists look to the cosmos, and Malicse ties it to balance, no single model has claimed consensus. Perhaps this diversity is the point: consciousness, as both a scientific and existential question, invites endless exploration. -/- In conclusion, the study of consciousness reveals as much about human inquiry as it does about the mind. Established theories like IIT and GWT provide concrete frameworks, while speculative ideas like panpsychism and Malicse’s Universal Law of Balance stretch our imagination. Malicse’s contribution, though underrecognized, offers a compelling synthesis—consciousness as the awareness of balance, uniting brain, body, and beyond. Whether we’ll ever solve this riddle remains uncertain, but the journey through these ideas illuminates the depth of what it means to be aware. For now, consciousness remains a mirror reflecting our quest to understand ourselves, one theory at a time. -/- . (shrink)

The 20th century was a bloody one, full of armed clashes which destroyed Europe, withered an entire generation’s hope of European-level peace. After the Versailles Treaty, the famous economist John Maynard Keynes uttered this prophecy: ”With such a peace treaty, you’ll be at war again within 20 years”. John Maxwell Coetzee, an important South-African novelist, called the 20th century “Satan’s century”. A tough statement yet extremely true unfortunately. Besides war, the past one hundred years also witnessed terrible totalitarian regimes occur, (...) such as the Nazi and fascism. The hardness of those regimes at least equaled the suffering caused by the world wars. One wouldn’t be wrong to call such regimes state terrorism: a leader suppressing his own citizens just to satisfy his own fantasy. The hugeness of their deeds goes beyond human imagination according to the number of victims. A classical word of wisdom describes terrorism as follows: ”It kills a few, but terrifies more”. (shrink)

There is a theological puzzle concerning the way in which Satan – an angel – was able to sin, despite lacking knowledge of no relevant fact about the world. Anselm and Aquinas explain Satan’s sin as malicious in virtue of Satan’s indifference to what mattered. I appeal to their account of Satan’s sin as a paradigm case clarifying the way in which those who intentionally engage in nonconsensual sex are always acting maliciously. Assuming competence, those who engage in nonconsensual sex (...) fail to attend to what matters and are willing to harm others merely for their own gratification. Such attitudes are diabolical. (shrink)

Though academic debate over gender-inclusive God-talk seems to have fizzled, the issue is a pressing one within many Christiandenominations today—both within and outside the Church—and for that reason deserves to be briefly revisited. Accordingly, althoughin this essay we approach the issue as professional philosophers, our focus is on the life of the Church—more specifically, those no doubt sizable segments of the Church for which a personal God and Satan exist and evangelism matters. Running an elimination argument, we contend that if (...) a certain sort of feminist concern about traditional God-talk is well-directed, the best response is to speak of not only God but also Satan in both masculine and feminine terms. And in closing, we address the possible worry that this response to the God-talk problem would not be Christian enough. (shrink)

Ingarden’s puzzle is: how can we come to know what is essentially involved in an act of knowing? As starting point he takes what he holds to be a particular good candidate example of such an act, namely an act of perceiving an apple. Here we have act and object standing in a certain first-level relation to each other. We now in a second level act of reflection, make this first-level relation into an object, and strive to apprehend this (...) object as an instantiation of the essence knowledge. But how, on this basis, could we ever establish that we had indeed grasped this essence, and that this is indeed the appropriate essence? Surely, through some third-level act of reflection on this second-level act. We expound from an ontological point of view Ingarden's idea as to how this regress can be avoided. (shrink)

Ingarden’s puzzle is: how can we come to know what is essentially involved in an act of knowing? As starting point he takes what he holds to be a particular good candidate example of such an act, namely an act of perceiving an apple. Here we have act and object standing in a certain first-level relation to each other. We now in a second level act of reflection, make this first-level relation into an object, and strive to apprehend this (...) object as an instantiation of the essence knowledge. But how, on this basis, could we ever establish that we had indeed grasped this essence, and that this is indeed the appropriate essence? Surely, through some third-level act of reflection on this second-level act. We expound from an ontological point of view Ingarden's idea as to how this regress can be avoided. (shrink)

Apple CEO Tim Cook claimed in 2019 that his company’s greatest achievement will be “about health.” But the pandemic has shown that Big Tech’s involvement in health care is all about data collection.

The agent portrayed in much philosophy of action is, let's face it, a square. He does nothing intentionally unless he regards it or its consequences as desirable. The reason is that he acts intentionally only when he acts out of a desire for some anticipated outcome; and in desiring that outcome, he must regard it as having some value. All of his intentional actions are therefore directed at outcomes regarded sub specie boni: under the guise of the good. This agent (...) is conceived as being capable of intentional action—and hence as being an agent—only by virtue of being a pursuer of value. I want to question whether this conception of agency can be correct. Surely, so general a capacity as agency cannot entail so narrow a cast of mind. Our moral psychology has characterized, not the generic agent, but a particular species of agent, and a particularly bland species of agent, at that. It has characterized the earnest agent while ignoring those agents who are disaffected, refractory, silly, satanic, or punk. I hope for a moral psychology that has room for the whole motley crew. I shall begin by examining why some philosophers have thought that the attitudes motivating intentional actions involve judgments of value. I shall then argue that their conception of these attitudes is incorrect. Finally, I shall argue that practical reason should not be conceived as a faculty for pursuing value. (shrink)

Michael Wendeler’s disputation on the Turkish republic is a discussion of Ottoman history, political philosophy, and the concept of monarchy and tyranny. Half of his disputation concerns the identification of the Turks with the little horn which arises on the head of the fourth beast in the prophet’s vision described in the Book of Daniel 7:1–28. Giving copious historical references, Wendeler explains that this little horn cannot be referring to Christ as the Jews believe, nor to the Seleucid monarch Antiochos (...) Epiphanes as the Calvinists believe. Nor can it be identifed with the Antichrist as the Catholics believe. Wendeler puts forth a detailed argument that the little horn on the fourth beast in the prophecy of Daniel can only be identified with the Turkish monarch (Ottoman Sultan). In conclusion, Wendeler draws a parallel between the monstrous ‘little horn’—the tyrannical Turkish monarchy—and the tyranny of the Catholic Church, exemplified by the untrustworthy Pope and the satanic writings of the Catholic Machiavelli. (shrink)

Since Antoine Faivre's emergence and establishment of "Western esotericism" in the late twentieth century, the discourse of globalising esotericism (beyond the West) has been fraught with controversy. As there are several polemical conversations about how such an effort should manifest itself in esoteric scholarship. This comparative, descriptive, and religionist approach to esotericism explores the intricate relationship between sexuality and spirituality by understanding the intersections of these aspects as manifested in Western, Eastern, and African esoteric currents, from Aleister Crowley's magia sexualis (...) to Marie Laveau (The Widow Paris)'s "Gris-Gris". Firstly, this is achieved by bringing said geographical regions into dialogue with one another, determining how esotericism fits into the overall trajectory of the origins of religion. Secondly, delving into the polemics and history of sexuality: from Foucault to Freud. Thirdly, positioning an esoteric spirituality in the digital era. Consequently, through identifying currents in the West, East, and Africa: including Paganism, Thelema, Satanism, New Age, and Theosophy in the West and Egyptian Paganism, Hinduism, and Buddhism in the East, in addition to African Traditional Religion (ATR), Sufi Islam, and Afro-American "Conjure" in Africa. This study, when intersected with philosophical conceptualisations of the self, contributes to a novel understanding of sexuality as sacred post-theistic (self-) spirituality, with esotericism serving as the foundation for such an approach. (shrink)

I am looking at an apple. The apple has a lot of properties and some, but not all, of these are part of my phenomenology at this moment: I am aware of these properties. And some, but not all, of these properties that I am aware of are part of my perceptual (or sensory) phenomenology. If I am attending to the apple’s color, this property will be part of my perceptual phenomenology. The property of being a granny (...) smith apple from Chile is unlikely to be part of my perceptual phenomenology. Here are two problems for anyone who is interested in conscious experience in general, and perceptual experience in particular: (a) How can we tell which properties are part of our phenomenology and which ones are not? (b) How can we tell which properties are part of our perceptual phenomenology and which ones are part of our non-perceptual phenomenology? I will focus on (b) in this paper. My aim is twofold: I propose a methodology for answering the question of which properties are part of our perceptual phenomenology and I provide an example for how this methodology could be applied. (shrink)

Many people have recently argued that we need to distinguish between experiences and seemings and that this has consequences for views about how perception provides evidence. In this article I spell out my take on these issues by doing three things. First, I distinguish between mere sensations like seeing pitch black all around you and perceptual experiences like seeing a red apple. Both have sensory phenomenology in presenting us with sensory qualities like colors, being analog in Dretske's sense, and (...) being fine-grained. However, only the latter have furthermore a perceptual phenomenology characterized by objectification and related dualities of perspectivality/completion and variation/constancy. Second, I elaborate on the reasons for thinking that both mere sensations and perceptual experiences need to be distinguished from accompanying seemings that passively assign things into conceptual categories and thereby tell you something about them. For example, when you look at a red apple and have the relevant recognitional abilities it will also normally seem to you that this is an apple. Finally, I argue that the best version of the popular dogmatist view about evidence is one which claims that it's neither experiences nor seemings by themselves, but rather the right sorts of composites of experiences and seemings that provide evidence. (shrink)

Agency is a power, but what is it a power to do? The tradition presents us with three main answers: (1) that agency is a power to affect one’s own will, consequent upon which act further events ensue, beginning with the movement of a part of one's body; (2) that agency is a power to affect one’s own body, consequent upon which act further events ensue, beginning with the movement of an object that one touches; and (3) that agency is (...) a power to affect that material upon which one brings one's action to bear---e.g. the apple one is peeling (with a knife in one's hand). These three answers correspond to three increasingly expansive conceptions of the province of human agency. I refer to them, respectively, as volitionalism, corporealism and materialism. Only the first two are seriously considered in contemporary action theory. Favoring the third, and hoping to sharpen the conflict between the third and the first, I criticize the second. Corporealism has been a popular position—arguably, the default position in the philosophy of action—since Donald Davidson’s classic paper “Agency” (1971). Although it seems to occupy a sensible middle ground between volitionalism and materialism, corporealism is, I argue, indefensible: it shares the vulnerabilities of both its two rivals, without possessing the strengths of either. Nevertheless, reflection on corporealism lights the road to materialism, which, in the end, is the only possible alternative to volitionalism. (shrink)

1. The Bundle Theory I shall discuss is a theory about the nature of substances or concrete particulars, like apples, chairs, atoms, stars and people. The point of the Bundle Theory is to avoid undesirable entities like substrata that allegedly constitute particulars. The version of the Bundle Theory I shall discuss takes particulars to be entirely constituted by the universals they instantiate.' Thus particulars are said to be just bundles of universals. Together with the claim that it is necessary that (...) particulars have constituents, the fundamental claim of the Bundle Theory is: (BT) Necessarily, for every particular x and every entity y, y constitutes x if and only ify is a universal and x instantiates y. 2 The standard and supposedly devastating objection to the Bundle Theory is that it entails or is committed to a false version of the Principle of Identity of Indiscernibles (Armstrong 1978: 91, Loux 1998: 107), namely: (Pll) Necessarily, for all particulars x and y and every universal z, if z is instantiated by x if and only if z is instantiated byy, then x is numerically identical with y. The most famous counterexample to the Identity of Indiscernibles is that put forward by Max Black, consisting of a world where there are only two iron spheres two miles apart from each other, having the same diameter, temperature, colour, shape, size, etc (Black 1952: 156). Let us from now on think of the properties of the spheres in this world as universals. The possibility of this world, which I shall hereafter refer to as 'Black's world', makes (Pll) false.' And according to common philosophical opinion this means that the Bundle Theory is false.. (shrink)

John D. Norton is responsible for a number of influential views in contemporary philosophy of science. This paper will discuss two of them. The material theory of induction claims that inductive arguments are ultimately justified by their material features, not their formal features. Thus, while a deductive argument can be valid irrespective of the content of the propositions that make up the argument, an inductive argument about, say, apples, will be justified (or not) depending on facts about apples. The argument (...) view of thought experiments claims that thought experiments are arguments, and that they function epistemically however arguments do. These two views have generated a great deal of discussion, although there hasn’t been much written about their combination. I argue that despite some interesting harmonies, there is a serious tension between them. I consider several options for easing this tension, before suggesting a set of changes to the argument view that I take to be consistent with Norton’s fundamental philosophical commitments, and which retain what seems intuitively correct about the argument view. These changes require that we move away from a unitary epistemology of thought experiments and towards a more pluralist position. (shrink)

Hailed as "a feast" (Washington Post) and "a modern-day bestiary" (The New Yorker), Stephen Asma's On Monsters is a wide-ranging cultural and conceptual history of monsters--how they have evolved over time, what functions they have served for us, and what shapes they are likely to take in the future. Beginning at the time of Alexander the Great, the monsters come fast and furious--Behemoth and Leviathan, Gog and Magog, Satan and his demons, Grendel and Frankenstein, circus freaks and headless children, right (...) up to the serial killers and terrorists of today and the post-human cyborgs of tomorrow. Monsters embody our deepest anxieties and vulnerabilities, Asma argues, but they also symbolize the mysterious and incoherent territory beyond the safe enclosures of rational thought. Exploring sources as diverse as philosophical treatises, scientific notebooks, and novels, Asma unravels traditional monster stories for the clues they offer about the inner logic of an era's fears and fascinations. In doing so, he illuminates the many ways monsters have become repositories for those human qualities that must be repudiated, externalized, and defeated. (shrink)

Introduction. The book is a study in Adam Smith's system of ideas; its aim is to reconstruct the peculiar framework that Adam Smith’s work provided for the shaping of a semi-autonomous new discipline, political economy; the approach adopted lies somewhere in-between the history of ideas and the history of economic analysis. My two claims are: i) The Wealth of Nations has a twofold structure, including a `natural history' of opulence and an `imaginary machine' of wealth. The imaginary machine is a (...) kind of Newtonian theory, whose connecting links are principles; provided either by `partial' characteristics of human nature or by analoga of physical mechanisms transferred to the social world; ii) a domain of the economic, understood as a self-standing social sub-system, was discovered first by Adam Smith. His `discovery' of the new continent of the economic was an `unintended result' of a deviation in his voyage to the never-found archipelago of natural jurisprudence. -/- 1. Imaginary machines and invisible chains: natural philosophy and method. The first chapter reconstructs Smith's views on the method in natural philosophy, presented primarily in the History of Astronomy (HA). The peculiar kind of semi-sceptical Newtonianism which permeates the essay is highlighted. Its reconstruction of the history of one natural science is shown to be based on the assumptions of Hume’s epistemology, and to lead to a self-aware deadlock. Smith's dilemma is between an essentialist realism and sceptical instrumentalism; the Cartesian presuppositions he shares with Hume and with the 18th century as a whole make it impossible for him to overcome his dilemma. The following chapters will show how, on the one hand, Smith's skeptical methodology encourages him in the enterprise to `carve off' a new self-contained discipline and how, on the other hand, his epistemological dilemma is reflected in the inner tensions of his moral and political theory as well as in a number of basic oscillations concerning the status of the new discipline. -/- 2. Chessboards and clocks: moral philosophy and method. -/- The second chapter reconstructs Smith's views on the method in the parallel field of moral philosophy, including the theory of moral sentiments and natural jurisprudence. I argue that The Theory of Moral Sentiments, when considered together with with the Lectures on Jurisprudence, where Smith's peculiar version of a `weaker' form of natural law is presented, wins special interest, not only for the history of ethics but even more for the history of political theory and the social sciences. The two most striking features of Smith's work in this area are highlighted. First, his effort at reformulating the `practical science' is a methodologically self-aware attempt at applying the Newtonian method to moral subjects. Secondly, this attempt ends in a stalemate as two distinguished kinds of normative order are introduced: one ultimate order of Reason, ultimately justifiable but inaccessible, and one weaker order of our `natural sentiments', to which we have empirical access, but which is so variable as to lack any ultimate value as a basis for grounding our normative claims. These two parallel conundrums may arguably account for the author's inability to publish during his lifetime both The History of Astronomy and the projected history and theory of law and government. -/- 3. Wheels, dams, and gravitation: the structure of scientific argument in The Wealth of Nations. -/- The third chapter provides the core of the book, dealing with the structure of the argument in WN. I argue that the main presupposition that makes the shift possible from a `natural history' to a `system' approach is the Newtonian contrast of `mathematical' with `physical' explanation; that is, Smith drops any discussion of the "original qualities" of human nature that could account for economic behaviour, while introducing, as `principles' for the system, a set of `hypothetical' statements of `observed' regularities in human behaviour and of `observed' super-individual self-regulating mechanisms. In bringing this presupposition to light, the coexistence of a teleological with a mechanistic approach is clarified; fresh light is shed on the notion of the invisible hand by a comparison of its occurrence in Smith with the occurrence of the same expression (until now overlooked) in the correspondence between Newton and Cotes. Finally, the peculiar semi-prescriptive and semi-descriptive character of political economy are highlighted, and the consistency of Smith's `impure' semi-prescriptive social science, when understood in his own terms, is defended against familiar charges with inconsistency and against even more familiar strained modernizations. -/- 4. Apples, deer, and frivolous trinkets: the construction of the economic. -/- The fourth chapter draws consequences from the third, examining how Smith's achievement in political economy, marking its transition to scientific status, carried a re-description of the phenomena, creating the comparatively independent and unified field of the economic. Smith's achievement is interpreted not as the `discovery' of an autonomous character already possessed by the economy out there, so much as a Gestalt-switch by which our perception of social phenomena is modified making us `see' the partial order of the economy as an isolated system. To sum up, the autonomy of the economic in social reality and the autonomy of the economic in social consciousness are shown to be two sides of one process. -/- 5. Concluding considerations: Political economy and the Enlightenment halved. -/- A few suggestions on the status of economic theory two centuries after The Wealth of Nations in its relationship to ‘practical philosophy’ are illustrated. (shrink)

Intellectual property has become the apple of discord in today’s moral and political debates. Although it has been approached from many different perspectives, a final conclusion has not been reached. In this paper I will offer a new way of thinking about intellectual property rights (IPRs), from a left-libertarian perspective. My thesis is that IPRs are not (natural) original rights, aprioric rights, as it is usually argued. They are derived rights hence any claim for intellectual property is weaker than (...) the correlative duties attached to self-ownership and world-ownership rights, which are of crucial importance in any left-libertarian view. Moreover, IPRs lack priority in front of these two original rights and should be overridden by stronger claims of justice. Thus, as derived rights, IPRs should not benefit of strong enforcement like any original rights especially if it could be in the latters’ detriment. (shrink)

The performance of one option can entail the performance of another. For instance, baking an apple pie entails baking a pie. Now, suppose that both of these options—baking a pie and baking an apple pie—are permissible. This raises the issue of which, if either, is more fundamental than the other. Is baking a pie permissible because it’s permissible to bake an apple pie? Or is baking an apple pie permissible because it’s permissible to bake a pie? (...) Or are they equally fundamental, as they would be if they were both permissible because, say, they both accord with Kant’s categorical imperative? I defend the view that the permissibility of an option that entails another is more fundamental than the permissibility of the option that it entails. That is, I defend maximalism: the view that if an agent is permitted to perform a certain type of action (say, baking a pie), this is in virtue of the fact that she is permitted to perform some instance of this type (say, baking an apple pie), where φ-ing is an instance of ψ-ing if and only if φ-ing entails ψ-ing but not vice versa. If maximalism is correct, then, as I show, most theories of morality and rationality must be revised. (shrink)

The Story of Adam and Eve: A Comprehensive Analysis -/- The story of Adam and Eve is one of the most profound and influential narratives in human history. Found in the Bible (Genesis), the Qur’an, and other religious traditions, it has shaped how people understand free will, morality, knowledge, sin, and redemption. This essay explores the story’s theological, philosophical, psychological, mythological, scientific, and literary implications. -/- 1. Theological Perspectives -/- A. Judaism: The Human Moral Struggle -/- In Judaism, the story (...) appears in Genesis 2–3, but it is not seen as the source of “original sin.” Instead, it represents the human struggle between good and evil inclinations. The serpent is not necessarily Satan but a symbol of temptation and human desires. Adam and Eve’s exile from Eden is interpreted as humanity’s transition to responsibility rather than an eternal punishment. -/- B. Christianity: Original Sin and Redemption -/- Christianity, particularly in Augustinian theology, views Adam and Eve’s sin as the cause of original sin, which is inherited by all humanity. The serpent is identified as Satan (Revelation 12:9), deceiving mankind. Jesus Christ is considered the “New Adam,” bringing salvation to humanity (Romans 5:12-21). The story lays the foundation for Christian doctrines of sin, salvation, and divine grace. -/- C. Islam: A Test, Not a Fall -/- In Islam, the story appears in the Qur’an (Surahs 2:30-39, 7:11-25, 20:115-124). Here, Satan (Iblis), not the serpent, tempts Adam and Eve. However, unlike Christianity, Adam and Eve repent, and Allah forgives them, emphasizing that humans are not doomed by original sin but are responsible for their own choices. Their descent to Earth is seen as a divine test rather than a punishment. -/- 2. Philosophical Perspectives -/- A. Free Will and Moral Responsibility -/- The story raises fundamental philosophical questions: Did Adam and Eve truly have free will? If God knew they would disobey, was their choice real, or was it predetermined? This aligns with compatibilism, the idea that free will exists within divine or natural laws. -/- B. The Nature of Good and Evil -/- The Tree of Knowledge of Good and Evil symbolizes moral awareness. Was eating the fruit an act of rebellion or enlightenment? Søren Kierkegaard interpreted the story as an example of “anxiety”—the moment humans became aware of moral responsibility. -/- C. Existentialist Interpretation -/- For existentialists like Jean-Paul Sartre, Adam and Eve’s exile from Eden represents alienation, a central theme in existentialism. Their story mirrors the human search for meaning after gaining self-awareness. -/- 3. Psychological Perspectives -/- A. The Transition from Innocence to Awareness -/- The story mirrors human development from childhood innocence to adulthood self-awareness. Sigmund Freud saw the forbidden fruit as a metaphor for repressed desires—with the serpent representing instincts and God’s law representing moral conscience. Carl Jung interpreted the story as an example of individuation, the process of integrating all aspects of the self. -/- B. Guilt and Shame -/- Before eating the fruit, Adam and Eve were unashamed of their nakedness—symbolizing innocence. After eating, they experienced guilt and shame, reflecting how humans develop a moral conscience. -/- 4. Mythological and Cross-Cultural Comparisons -/- Many creation myths explore similar themes: -/- 5. Scientific and Evolutionary Interpretations -/- A. Anthropological View -/- The story might symbolize the emergence of early human consciousness, when humans first developed self-awareness and moral codes. -/- B. Neuroscientific View -/- Modern neuroscience suggests that the shift from instinct-driven behavior to rational moral reasoning mirrors the brain’s evolution. The story represents the emergence of the prefrontal cortex, responsible for decision-making and morality. -/- 6. Literary and Symbolic Interpretations -/- A. Eden as a Utopia -/- The Garden of Eden represents a perfect world that humans lost due to their choices. -/- B. The Serpent as Knowledge -/- Some interpretations suggest the serpent is a bringer of enlightenment, not just a deceiver. -/- C. The Banishment as Transformation -/- Leaving Eden is not merely exile but a necessary step in human progress—the beginning of human civilization. -/- 7. Conclusion: The Universal Meaning of Adam and Eve -/- The story of Adam and Eve transcends religious traditions, offering insights into human nature, morality, and free will. -/- Religiously, it teaches about obedience, sin, and redemption. -/- Philosophically, it raises questions about free will, knowledge, and morality. -/- Psychologically, it represents human development and self-awareness. -/- Mythologically, it connects to ancient themes of knowledge and consequence. -/- Scientifically, it mirrors human evolution and moral consciousness. -/- Literarily, it serves as a metaphor for humanity’s transition from innocence to wisdom. -/- Ultimately, the story of Adam and Eve is not just about the past—it continues to shape the way we think about the present and the future. -/- . (shrink)

This report aims to offer insights into cutting-edge research on digital well-being. Many of these insights come from a 2-day academic-impact event, The Future of Digital Well-Being, hosted by a team of researchers working with the Royal Netherlands Academy of Arts and Sciences (KNAW) in February 2024. Today, achieving and maintaining well-being in the face of online technologies is a multifaceted challenge that we believe requires using theoretical resources of different research disciplines. This report explores diverse perspectives on how digital (...) well-being can be actively cultivated, while also emphasising the importance of considering individual differences, societal contexts, and nuanced cultural factors. We aim to offer a holistic view of the future of digital well-being, one that will inspire the next generation of designers of online tools, as well as policymakers who will regulate these tools. We start by asking what digital well-being is – how we can best define a concept that is used by diverse stakeholders and researchers from many disciplines in various ways. To do this, we explore the classic ethical theories of well-being, showing how they can give us insights into how the term digital well-being is currently deployed. We then move to look at the existing strategies that have been proposed to actively cultivate digital well-being, exploring the business models that threaten digital well-being and the relative advantages of the digital and non-digital solutions that are currently proposed. On the one hand, digital tools – such as Apple’s Screen Time and app blockers such as Opal and Forest – integrate seamlessly with the digital lifestyles of users. They also create precise metrics for digital well-being, which facilitates their solutions to reduce screen time. On the other hand, non-digital solutions, including mindfulness practices, digital detoxes, and digital well-being coaching, offer a new set of tools to reconnect individuals to their natural rhythms and help to actively promote offline activities. We then move to discuss diversity and how various groups of users have strikingly different digital well-being needs. Embracing neurodiversity in digital well-being is crucial as it strongly impacts the users’ experience of online technologies. When designing for diversity, organisations and designers alike need to prioritise customization for people with physical disabilities, mitigate harmful content for users with mental well-being conditions, address gender stereotypes and online harassment, and be designed in ways that recognize the very real risks of online technologies. This report closes by examining cultural differences. We believe that non-Western conceptions of well-being offer rich sources for enhancing digital well-being insofar as these traditions can inform and inspire the designers of future online technologies. We focus on East-Asian and South-Asian traditions, although in further work we recognise it would be useful to investigate conceptions of well-being that are influential in the Gulf region, Africa, and South America. Each of these areas have ethical frameworks that discuss well-being in depth as well as a rich cultural heritage. In conclusion, this report’s insights underscore the imperative of recognizing diversity in digital well-being, both in terms of cultural contexts and disciplinary perspectives. It emphasises the need for culturally responsive design methodologies and the integration of non-Western philosophical perspectives into current digital well-being research. Embracing this diversity, we believe, offers the best chance to create digital environments that prioritise well-being for users and the societies they live in across the world. Ultimately, we believe that it is not only about designing better online products; it’s about shaping a digital landscape that promotes well-being and flourishing for everyone. (shrink)

RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE OS CIOS OU ESTROS SILENCIOSOS EM VACAS E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede CIOS OU ESTROS SILENCIOSOS EM BOVINOS INTRODUÇÃO Um cio ou "estro silencioso" ocorre quando as mudanças ováricas são normais, mesmo com ovulação, mas não há comportamento estral. Isso não deve ser confundido com um estro não observado devido a falha na detecção do mesmo. A ocorrência do cio ou "estro (...) silencioso" é mais frequente durante o primeiro e segundo ciclo pós-parto (25 a 40 dias pós-parto). O acesso ao comportamento de atividade estral geralmente é gradual e ocorre em várias horas. Assim, a intensidade do estro e o padrão típico de comportamento em uma determinada vaca, variará do começo ao fim do mesmo. O conhecimento dessas mudanças graduais do estro servem como sinais e podem ser usados pelo produtor para indicar se uma vaca está manifestando o início ou a finalização do estro. (FRAZER, 2005; GORDON, 1996). O fracasso da detecção do estro é o problema mais sério e generalizado que afeta a eficácia do serviço nas vacas. Vários fatores de manejo contribuem para o fracasso no diagnóstico do estro, mas a incapacidade de reconhecer os sinais do estro é uma causa comum. A detecção do estro é necessária para um programa de inseminação das vacas leiteiras e é a chave do uso bem sucedido da inseminação artificial (AI) (THATCHER et al., 2006). As temperaturas ambientes quentes ou muito frias reduzem o comprimento dos períodos estrais em algumas vacas, e incrementam as dificuldades na detecção do estro. Quando a vaca manifesta o estro, exibe padrões de comportamento que são distintamente diferenciados do descanso do ciclo estral. Relaciona-se com o estro, o maior desenvolvimento folicular ovárico e a descarga reforçada de estrogênio. O estrogênio, hormônio sexual do ovário, atua na vaca causando a indução do comportamento estral. Cios/estros silenciosos podem ser difíceis de se manifestarem na vaca, uma vez que torna-se muito difícil não observar uma vaca, que mesmo tendo um cio silencioso, aceitando a monta ou montando em outras, o muco que escorre pela vulva, o comportamento de micção frequente, etc. Vários fatores podem ocasionar essa manifestação ociosa do cio, porém a mais relevante é a nutricional, em especial com a deficiência ou exagero de minerais essenciais e intimamente relacionados com a reprodução. 9.1 Minerais 9.1.1 Fósforo (P) Dentro das deficiências minerais, o baixo nível de fósforo afeta os mecanismos energéticos relacionados com as manifestações corporais do cio. Os hábitos de comportamento típico de montar e deixar-se montar, o evento de caminhadas errantes em busca de companheiros sexuais unido ao baixo consumo de alimento durante as horas de estro, leva a atentar que, sob condições de deficiência mineral de fósforo, o animal não mostre seu comportamento sexual esperado, já que outros processos fisiológicos, todos relacionados com as funções autônomas, devem ser favorecidos. Sempre enfatizando a prevenção por afecções relacionadas aos minerais que possuem relação direta com a fertilidade e reprodução dos bovinos, a suplementação do P pode ocorrer de diversas maneiras, dentre elas o fornecimento de 1,43 mg/kg de MS do mineral na dieta dos animais, tendo uma taxa percentual de 0,17 a 0,59% de P presente em kg/MS para todas as categorias animais, o que previne ou combaterá quaisquer anomalias que viera a acometer o rebanho. A administração dessa quantidade pode ocorrer em sistemas de fornecimento via SMI (suplementação mineral injetável), via água, forragens ou via ração. 9.1.2 Manganês (Mn) A maioria dos efeitos de deficiência do Mn deve-se à sua função na síntese de muco polissacarídeo, estes são imprescindíveis na matriz orgânica dos ossos e dos dentes. Outra função do Mn é a participação nos processos de oxido-redução, respiração tecidular, formação do osso, reprodução e funções endócrinas. Os bovinos que têm uma baixa ingestão de manganês nas suas dietas podem ter uma puberdade tardia, baixas porcentagens de gravidez, uma acentuada tendência aos abortos e bezerros fracos ao nascer. Como sempre falado, todos os minerais são essenciais para a manutenção e normalidade do corpo e dos mecanismos fisiológicos do mesmo, logo, como o Mn não é diferente, sua participação na dieta do animal deve obedecer os 40 mg/kg de MS e nunca superior a 1000 ppm, as concentrações desse mineral são mais abundantes em forragens e sua via de suplementação pode ser através da ração balanceada com todas as quantidades estabelecidas de macro e micro minerais ou através do sistema SMI. 9.1.3 Cobre (Cu) Outro mineral relacionado com o cio ou estro silencioso é o cobre. As vacas que consomem pastos deficientes em cobre podem apresentar uma infertilidade associada a cios atrasados ou suprimidos, falhas na nidificação, reabsorções embrionárias e transtornos na espermatogênese nos machos. Os bovinos que consomem pastagens contendo menos que 3 mg Cu/kg MS por dia apresentam sinais de deficiência. As desordens reprodutivas relacionadas com o cobre (Cu) podem estar relacionadas a uma deficiência, bem como a uma interferência na sua utilização. A disponibilidade desse elemento pode ser reduzida pelo excesso de outros, como exemplo o molibdênio, enxofre, ferro, cálcio, zinco e cádmio (QUIROZ-ROCHA & BOUDA, 2001; KINCAID, 1999). O Cu é um elemento primordial como outro qualquer, sendo assim, sua administração aos animais deve obedecer aos parâmetros estabelecidos por instituições de pesquisa agropecuária que ditam um fornecimento de Cu entre 10-18 mg/kg de MS para todas as categorias animais. A via de suplementação do cobre pode ser diversa, mas as mais aceitas são pelas forragens, pelo sistema SMI ou através do concentrado balanceado industrial. O excesso de Cu gera Mo, e a relação entre ambos não deve ser superior à 20. Por fim, em geral, cio/estro silencioso se apresentará em deficiências de energia pelos altos requerimentos desta durante o período do mesmo, e quando se apresentam os desequilíbrios eletrolíticos, uma vez que a homeostase básica faz com que os processos de regulação bioquímica sejam prioritários para o indivíduo, ainda sobrepondo suas necessidades reprodutivas. REFERÊNCIAS BIBLIOGRÁFICAS BARRENHO, Gonçalo José Pinheiro. Nutrição e fertilidade em bovinos de leite. 2016. Dissertação de Mestrado. Universidade de Évora. BERCHIELLI, Telma Teresinha; PIRES, Alexandre Vaz; OLIVEIRA, SG de. Nutrição de ruminantes. Jaboticabal: funep, 2006. BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. DEHNING, R. Interrelaciones entre nutriión y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. DIAS, Juliano Cesar et al. Alguns aspectos da interação nutrição-reprodução em bovinos: energia, proteína, minerais e vitaminas. PUBVET, v. 4, p. Art. 738-743, 2010. FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. FUCK, E. J.; MORAES, G. V.; SANTOS, G. T. Fatores nutricionais na reprodução das vacas leiteiras. I. Energia e proteína. Rev Bras Reprod Ani, v. 24, p. 147-161, 2000. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. KINCAID, R. L. Assessment of trace mineral status of ruminants: A review. In: Proceedings of the American Society of Animal Science. 1999. p. 1-10. MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. QUIROZ-ROCHA, Gerardo F.; BOUDA, Jan. Fisiopatología de las deficiencias de cobre en rumiantes y su diagnóstico. Vet. Méx, v. 32, n. 4, p. 289, 2001. SARTORI, Roberto; GUARDIEIRO, Monique Mendes. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. THATCHER, W. W. et al. Strategies for improving fertility in the modern dairy cow. Theriogenology, v. 65, n. 1, p. 30-44, 2006. TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. TEIXEIRA, J. C. Nutrição de ruminantes. Lavras: FAEPE, 1992. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Epistemic Leaks and Epistemic Meltdowns: A Response to William Morris on Scepticism with Regard to Reason Mikael M. Karlsson I. In an excellent paper which appeared in the April, 1989 issue of this journal,2 William Morris attemptsto demonstrate thatthe arguments which make up Hume's notorious chapter, "Of scepticism with regard to reason, are, in the first place, coherent—both internally and with the overall strategy of the Treatise—and, in the (...) second place, successful. Morris' paper is an exercise in the noble art of what I style constructive exegesis, an enterprise to which many readers of Hume Studies, and myself as much as any, are committed. It is a guiding principle ofthis art that we donotunderstandaphilosophical textuntil we can interpret it in such a way as to render it both coherent and correct. From this point ofview, coherence and correctness are not as independent of one another as they may seem to be to others who are differently committed. Some texts, such as Hume's chapter, "Ofscepticism with regard to reason," are notoriously resistant to constructive exegesis, despite the formidable bag of tricks which scholars and interpreters have developed; so resistant, that in gloomier moments we may be brought to wonder about our interpretative enterprise itself. Constructive exegesis is indeed a strange, and peculiarly optimistic, enterprise. Someday, I imagine, in a leisurely moment, I will think more reflectively about the principles ofour art. But not now.6 As a fellow practitioner of constructive exegesis, I am in full sympathy with what Morris tries to do in his paper; and I think that he does contribute substantially to our understanding of what Hume is up to in the chapter, "Ofscepticism with regard to reason." The third section of Morris' paper is, in my judgement, particularly successful in showing how Hume's chapter fits into the larger framework of the Treatise: Hume is, we see, attacking both what Morris labels "intellectualist rationalism" and its counterpart, which we may call 'unmitigated scepticism', although the chapter's two main arguments go primarily to the former. I also think that Morris gives very helpful, Volume XVI Number 2 121 MIKAEL M. KARLSSON and to my mind accurate, accounts of these two arguments, which I dub, respectively, the epistemic leak argument, and the epistemic meltdown argument. However, I have personally never found either of these arguments remotely convincing; and I still do not, despite Morris' clarification and defense. In what follows, I shall indicate some ofthe reasons for my dissatisfaction.?. Theepistemicleakargumentpurportsto"prove"(in Hume's sense)that reason or demonstration cannot support knowledge. Morris rightlyreminds us that whatHume meansby knowledge is perfect assurance or conviction: Knowledge is, in short, subjective certainty. This has caused confusion, for this is not what we usually mean nowadays by knowledge; nor was it what people, philosophers included, generally meant prior to Descartes. In Hume itis the product ofthe attempttoresolve all epistemic statesintomental eventsorwhat he calls "perceptions." In any case, we must—as Morris rightly explains—be clear that the epistemic leak argument is aimed at showing that demonstration cannot supportperfect conviction. Inoutline, the argumentissimple: Itworks, asMorrismakes clear, by shifting attention away from the subject-matter or "objects" of demonstration, that is, relations of ideas, to the exercise of demonstrative reason by human agents. The necessity of relations of ideas may suggest to us that we can be certain about them. Against this, one may point out that people do err in the conclusions arrived at by demonstration; this presumably shows that our (rational) understandingis fallible. And once we recognize this, our confidence in any conclusion produced by exercising this facultyislessened—thus do we move from knowledge, or subjective certainty, toprobability: belief, or imperfect conviction. Arguments ofthis general type (we can call them, using Descartes' famous figure, Totten-apple arguments ) were around long before Hume, although they were more commonly directed against the senses than against reason. We find them in antiquity—in Plato and Sextus Empiricus, for instance —and in Descartes, in parallel passages in the Discourse on Method, the First Meditation and the Principles of Philosophy, wherein one can discern a version directed precisely against reason and demonstration.12 To find out what, if anything, Hume has... (shrink)

RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE O CORPO LÚTEO PERSISTENTE EM VACAS E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede CORPO LÚTEO PERSISTENTE EM BOVINOS INTRODUÇÃO Essa alteração funcional da estrutura ovárica está relacionada com uma lise incompleta do corpo lúteo, o que leva à presença de níveis subnormais de progesterona bloqueando a ciclicidade ovárica ao retardar a retroalimentação para a ação dos estrogênios durante o proestro e o estro. Os (...) principais fatores associados à manifestação da permanência do corpo lúteo são as lesões do endométrio que bloqueiam a produção de prostaglandinas e as deficiências nutricionais (FRAZER, 2005; GORDON, 1996), sob essa última é importante citar: 8.1 Minerais (Manganês Mn) A deficiência de manganês em vacas alimentadas com rações que contenham menos de 22 mg de Mn por Kg-¹ de MS parece causar anestro, cios silenciosos, atrasos na ovulação, baixos níveis de gestações à primeira cobrição e nascimento de bezerros deformados. A infertilidade ocorre principalmente em animais que consomem pastagens que crescem em solos com deficiência de manganês ou que são fertilizados com grandes quantidades de calcita, ou que recebem suplementos que contêm quantidades excessivas de cálcio. Os bovinos possuem exigências distintas de Mn conforme sua categoria e aptidão, por exemplo, o gado de corte requerem 40 mg/kg de Mn presente na MS, porém esse número pode variar entre 20-50 mg/kg de MS; o gado de leite requer as mesmas 40 gramas por quilo de matéria seca, mas o intervalo segundo institutos de pesquisa gira em torno de 12-14 mg/kg de MS, o que é controverso. O nível máximo permitido de Mn presente na MS não deve ultrapassar os 1000 ppm por kg, para que não altere os mecanismos fisiológicos do sistema digestivo nem acarrete possíveis transtornos reprodutivos ou não. As fontes de suplementação do mineral para os animais são diversas, o pasto com as gramíneas, forrageiras e leguminosas suprem bem as exigências, porém se for o caso pode-se inserir o Mn por meio da ração ou via injetável através do sulfato de manganês. Esse manejo é para garantir a prevenção não só do corpo lúteo persistente, mas sim de tantas outras alterações na fertilidade dos animais. Sendo um cofator de enzimas como as fosfoglicomutase, piruvato carboxilase e fosfoenolpiruvato carboxil quinase, o manganês tem um papel fundamental na gliconeogênese. A diminuição dos níveis de manganês no útero acarreta numa redução da resposta tecidular à ação de estrogênios, o que causaria a presença de cios irregulares e silenciosos, bem como uma menor síntese de prostaglandina levando, como efeito, a uma menor eficiência na luteólise. A prevenção é o melhor remédio, e se for o caso de combater o transtorno os métodos mais utilizados são a utilização paulatinamente do mineral por meio da ração ou do pasto para obter os resultados gradativamente. Deve-se estar atento as quantidades e a qualidade, para que em vez da deficiência não acometa um novo transtorno mediante a supermineralização do animal. 8.2 Nitratos, nitritos e ferro (Fe) Outra anormalidade nutricional que afeta os processos luteolíticos gerando o corpo lúteo persistente é a alta concentração de nitratos que, mediante processos de redução ruminal, se convertem em nitritos. Os nitratos acumulam-se em forragens, fenos fertilizados com nitrogênio ou sob estresse térmico (HENDRIX, 2003). Os efeitos do NO3 na fermentação dos carboidratos pela flora ruminal estimulam a produção de acetato em detrimento dos ácidos graxos glicogênicos. Os nitritos afetam a troca gasosa por desacoplamento ferroso na hemoglobina, impedindo uma oxigenação correta dos tecidos. Não havendo troca gasosa entre oxigênio e o CO2, os tecidos retêm a forma carbonada freando a cadeia de elétrons e reduzindo seu potencial energético, dessa maneira obstrui-se a irrigação nas células da granulosa, e a síntese de algumas substâncias como as prostaglandinas, procedendo-se, como efeito, o corpo lúteo retido. Estudos realizados demonstraram que mesmo que a ingestão de nitratos seja em baixas doses, leva a problemas reprodutivos quando a metahemoglobinemia alcança os 30% (ou seja, 30% do Fe+2 da hemoglobina foi convertido a Fe+3). Os nitratos e os nitritos são encontrados na água dos animais, logo o criador deve fazer uma análise laboratorial para estudar a viabilidade de consumo da mesma. Os valores não poderão ser maiores que 220 ppm para NO3 e maiores que 40-100 de N- NO3. Com relação ao Fe o ideal é a ingestão de 50 mg/kg de MS para todas as idades, tendo um intervalo sugerido entre 50-100 mg/kg de MS para gado de corte e de 12,3-18 em gado leiteiro. Para suplementar esses animais com uma boa e adequada ingestão de Fe pelos animais os grãos de cereais possuem 30-60 mg de Fe/kg de MS; as oleaginosas possuem entre 100-200 mg de Fe/kg de MS; as farinhas de produtos de origem animal são as mais expressivas em teor de Fe tendo entre 400-3000 mg do mineral por kg de MS, mas vale salientar que níveis acima de 1000 ppm ou 1000 mg/kg o Fe já torna-se tóxico para o animal e, por fim, as forrageiras possuem entre 70-500 mg de Fe/kg de MS. Logo, caso haja deficiência do mineral no plantel o criador poderá optar pela inserção do mesmo na ração, água ou via suplementação mineral injetável (SMI). Se todos os manejos forem praticados os transtornos tanto do corpo lúteo persistente quanto de demais alterações ou patogenias, como a anemia ferropriva, expressiva em suínos e em bovinos menos comum, podem ser prevenidas e/ou combatidas. 8.3 Energia Outra causa corrente e importante de alterações na reprodução por causas nutricionais na vaca, é o fracasso dos sistemas digestivo e hepático para fornecer energia suficiente para a manutenção, exercício, crescimento, gestação e lactação. Os problemas de infertilidade podem ter origem na baixa capacidade gliconeogênica. Vários estudos sugerem que, nos ruminantes, o principal fator que regula a insulinogênese é a glicemia e que o propionato tem um baixo poder insulinogênico. Por conseguinte, baixos níveis de glicemia conduzem a baixos níveis de insulina plasmática provocando, indiretamente, as alterações na sequência gonadotrófica e induzindo lise luteal incompleta. Pouco se sabe sobre as vias específicas em que a informação sobre o estado nutricional é convertida em sinais neuroendócrinos que afetam a secreção de GnRH. Os mecanismos propostos incluem os possíveis papéis das hormonas envolvidas no metabolismo intermediário, particularmente a insulina. Recentemente, com a descoberta da leptina, abriu-se um novo campo de estudo para as relações entre o estado nutricional e a reprodução na vaca leiteira. A leptina ocorre no tecido adiposo e tem efeitos sobre o consumo de energia, a deposição de reservas, a liberação de LH e a resposta a FSH e LH em células hipofisárias e em células granulosas. A ação gonadotrófica de LH e particularmente de FSH, é conhecida por ser modulada por outros hormônios e fatores de crescimento. Estes incluem a insulina, GH e IGF-I, que desempenham um papel importante no metabolismo intermediário de energia e são, nutricionalmente, regulados por si mesmos. Estudos apontam que tanto a glicose como os esqueletos carbonados de aminoácidos ou insulina e IGF-I podem modular a taxa de ovulação independentemente da circulação de concentrações de FSH devido a efeitos diretos no ovário sobre o desenvolvimento folicular. Se a disponibilidade de fósforo para o metabolismo celular for reduzida, é provável que haja um desequilíbrio com o potássio, o que levaria a uma diminuição do fluxo de energia. O mais evidente de todos é uma intervenção na reação ATP—ADP + ~P. As características próprias dos recursos alimentares somadas à sua utilização inadequada têm originado nas vacas de explorações leiteiras de sistemas intensivos, uma série de desequilíbrios nutricionais generalizados, caracterizados por deficiência de energia, excesso de proteína crua e nitratos (NO3-), deficiências de fibra, de Ca, de Mg e algumas vezes excessos de P e K (GALVIS, et al. 2001). Essa problemática tem origem nas práticas irracionais de gestão da propriedade e principalmente dos animais no que tange a alimentação dos mesmos. Com relação ao pasto, a problemática origina-se sobre a excessiva fertilização e períodos curtos de rotação dos pastos, que dão lugar a pastagens com baixa quantidade de matéria seca, o que pode condicionar o consumo de forragens de qualidade questionável e favorecer o déficit energético. Esse déficit de energia no início da lactância diminui as concentrações de hormônio luteinizante (LH), o que leva a concluir que a alteração ovárica seria determinada por uma alteração na liberação pulsátil de LH, provavelmente ocasionada por uma liberação anormal e reduzida de GnRH, isso levaria a cios silenciosos e corpos lúteos persistentes. Superficialmente, vale sempre lembrar que a prevenção é a melhor opção numa criação de bovinos, logo, os macro ou micro minerais devem estar inseridos na dieta animal em quantidades estabelecidas para não manifestar uma deficiência ou supermineralização. O Ca deve ser presente entre 0,17-1,53% em kg/MS e numa concentração máxima de 2% kg/MS para não ser tóxico. O P deve ser fornecido entre 0,17-0,59% em kg/MS e menor que 1000 mg/kg de MS nível mínimo para toxidade. O K entre 0,6-1,0 mg por kg/MS, uma vaca de 600 kg deve ingerir um total de 230 mg/dia de K, o nível de toxidade do K é > 3% em kg/MS. O Mg entre 0,05-0,35 mg/dia, em um nível tóxico ≥ 1% em kg/MS. Esses minerais, como falado anteriormente e sempre frisado para o agricultor ter todo alicerce possível, se limita aos grãos de cereais, leguminosas, oleaginosas, farinhas de origem animal e vegetal, forrageiras e outras fontes alternativas. Para aclarar o supracitado texto, observe a tabela que contém o mineral, a quantidade ideal de fornecimento baseado ao requerimento animal, o nível de toxidade o alimento que mais contém determinado mineral e as vias possíveis de suplementação em caso de deficiência. Tabela 1: Exigências minerais dos bovinos e quantidades ideais de fornecimento diário Mineral Quant. Exigida pelo animal* Nível de toxidade Alimento mais adequado Via de suplementação Manganês (Mn) 40 mg/kg de MS > 1000 ppm + em forragens Água/Pasto/Ração/SMI Ferro (Fe) 50 mg/kg de MS > 1000 ppm + em farinhas de origem animal > 400 mg/kg Água/Pasto/Ração/SMI Cálcio (Ca) 0,17-1,53% por kg/MS > 2% kg/MS + em forrageiras > 0,6% kg/MS Água/Pasto/Ração/SMI Fósforo (P) 0,17-0,59% por kg de MS > 1% kg/MS + em farinhas de origem animal > 0,6% Pasto/Ração/SMI Potássio (K) 0,6-1,0 mg/kg de MS Uma vaca com 600kg exige 230g/dia > 3% kg/MS + em forrageiras > 0,33% Pasto/Ração/SMI Magnésio (Mg) 0,05-0,35 mg/dia > 1% kg/MS ± grãos ∆ forrageiras e > leguminosas Água/Pasto/Ração/SMI * Referida a todas as idades. Dados obtidos pela pesquisa através de BERCHIELLI et al. 2006; TEIXEIRA, 1992 e 1997. REFERÊNCIAS BIBLIOGRÁFICAS BERCHIELLI, Telma Teresinha; PIRES, Alexandre Vaz; OLIVEIRA, SG de. Nutrição de ruminantes. Jaboticabal: funep, 2006. BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. FRAZER, Grant S. Bovine theriogenology. Veterinary Clinics: Food Animal Practice, v. 21, n. 2, p. xiii-xiv, 2005. GALVIS, Rubén D.; CORREA, Héctor J.; RAMÍREZ, Nicolás. Interacciones entre el balance nutricional, los indicadores del metabolismo energético y proteico y las concentraciones plasmáticas de Insulina, e IGF-1 en vacas en lactancia temprana. Revista Colombiana de Ciencias Pecuarias, v. 16, n. 3, p. 237-248, 2003. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. HENDRIX, F. W. Manejo de pasturas y problemas de pastoreo. Animal agriculture. WSU Extension. Washington State University. EUA, 2003. Disponível em:. Acesso em: Abril de 2020. MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. TEIXEIRA, J. C. Nutrição de ruminantes. Lavras: FAEPE, 1992. Emanuel Isaque Cordeiro da Silva Belo Jardim, 11 de abril de 2020. (shrink)