The Schwarzschild solution (Schwarzschild, 1915/16) to Einstein’s General Theory of Relativity (GTR) is accepted in theoretical physics as the unique solution to GTR for a central-mass system. In this paper I propose an alternative solution to GTR, and argue it is both logically consistent and empirically realistic as a theory of gravity. This solution is here called K-gravity. The introduction explains the basic concept. The central sections go through the technical detail, defining the basic solution for the geometric tensor, (...) the Christoffel symbols, Ricci tensor, Ricci scalar, Einstein tensor, stress-energy tensor and density-pressure for the system. The density is integrated, and some consistency properties are demonstrated. A notable feature is the disappearance of the event horizon singularity, i.e. there are no black holes. So far this is for a single central mass. A generalization of the solution for multiple masses is then proposed. This is required to support K-gravity as a viable general interpretation of gravity. Then the question of empirical tests is discussed. It is argued that current observational data is almost but not quite sufficient to verify or falsify K-gravity. The Pioneer spacecraft trajectory data is of particular interest, as this is capable of providing a test; but the data (which originally showed anomalies that match K-gravity) is now uncertain. A new and very practical experiment is proposed to settle the matter. This would provide a novel test of GTR, and a novel test of the cause of the Pioneer anomalies. In conclusion, K-gravity has extensive ramifications for gravitational physics and for the philosophy of GTR and space-time. (shrink)

Theory of everything must include consciousness. In this Part I of the series of three articles, we introduce the subjective experience (SE) and/or proto‐experience (PE) aspect of consciousness in classical physics, where PEs are precursors of SEs. In our dualaspect‐ dual‐mode PE‐SE framework, it was hypothesized that fundamental entities (strings or elementary particles: fermions and bosons) have two aspects: (i) material aspect such as mass, charge, spin, and space‐time, and (ii) mental aspect, such as experiences. There are three competing hypotheses: (...) (1) superposition based H1 (SEs/PEs are superposed in the mental aspect of entities; when a specific stimulus is presented to the neural‐network, the associated specific SE is selected by the matching and selection process and experienced by this network), (2) superposition‐then‐integration based H2 (only PEs are superposed, which are integrated by neural‐Darwinism leading to specific SEs) and (3) integration based H3 (each entity has its own PE, which keeps on transforming appropriately as matter evolves from elementary particles to neuralnetworks; it is a dual‐aspect panpsychism). We found that the followings, in classical physics, are invariant under the PE‐SE transformation: electromagnetic strength tensor, electromagnetic stress‐energy tensor, the electromagnetic theory (Maxwell's equations), Newtonian gravitational field, the entropic force, Special and General Theory of Relativity. Our analysis suggests that (i) SEs are embedded in space‐time geometry for the structure of space‐time (empty space or the vacuum without matter). (ii) For matter field, SEs can move with spatiotemporal coordinates of matter because it is in the mental aspect of matter as both mental and material aspects are always together in the dual‐aspect‐dual‐mode optimal PE‐SE framework. (iii) Our specific SE is the result of matching and selection processes and can change with space and time. For example, the experience redness has V4/V8/VO‐red‐green neural‐network with rednessstate as neural correlates. When a subject moves, the specific SE redness also moves with the subject’s correlated neural‐network. In addition, SEs can change with time as stimuli change. In other words, SEs in a subject change with space‐time. We conclude that it is possible to introduce the SE/PE aspect of consciousness in classical physics. In Parts II and III, the SE aspect of consciousness will be introduced in orthodox quantum physics and modern quantum physics (such as loop quantum gravity and string theory), respectively. Thus, the introduction of the SE aspect of consciousness in physics leads us to unify consciousness with known four fundamental forces, which entails towards a theory of everything. (shrink)

This report offers a modern perspective on the problem of negative energy, based on a reexamination of the concept of time direction as it arises in a classical and quantum-mechanical context. From this analysis emerges an improved understanding of the general-relativistic stress-energy of matter as being a manifestation of local variations in the energy density of zero-point vacuum fluctuations. Based on those developments, a set of axioms is proposed from which are derived generalized gravitational field equations (...) which actually constitute a simplification of relativity theory in the presence of negative-energy matter and a non-zero cosmological constant. Important clarifications are also achieved regarding the nature of the binary degrees of freedom of matter in the final stages of a gravitational collapse. Those results are then applied to provide original solutions to several long-standing problems in cosmology, including the problem of the nature of dark matter and dark energy, that of the origin of thermodynamic time asymmetry, and several other issues traditionally approached using inflation theory. Finally, we draw on those developments to provide significant new insights into the foundations of quantum theory, regarding, in particular, the problem of quantum non-locality, that of the emergence of time in quantum cosmology, as well as the question of the persistence of quasiclassicality following decoherence. (shrink)

Consensus in the contemporary philosophical literature has it that conserved quantity theories of causation such as that of Dowe [2000]—according to which causation is to be analysed in terms of the exchange of conserved quantities (e.g., energy)—face damning problems when confronted with contemporary physics, where the notion of conservation becomes delicate. In particular, in general relativity it is often claimed that there simply are no conservation laws for (say) total-stress energy. If this claim is correct, it is (...) difficult to see how conserved quantity theories of causation could survive. In this article, we resist the above consensus and defend conserved quantity theories from this conclusion, at least when focusing on the apparent problems posed by general relativity. We argue that this approach to causation can continue to be defended in general relativity, once one appreciates (a) the availability of approximate symmetries in generic general relativistic spacetimes, and (b) the role of modelling and idealisation in that theory. Given these points, conserved quantity theories of causation must stand or fall on other grounds. (shrink)

In the standard model of cosmology, λCDM, were introduced to explain the anomalies of the orbital velocities of galaxies in clusters highest according estimated by General Relativity the dark matter and the accelerated expansion of the universe the dark energy. The model λCDM is based in the equations of the General Relativity that of the total mass-energy of the universe assigns 4.9% to matter (including only baryonic matter), 26.8%, to dark matter and 68.3% to dark energy adjusted (...) according observed in Planck mission, therefore, excluding bosonic matter (quantum vacuum). However, the composition of dark matter and dark energy are unknown. Due to that it lacks of a correct physical theory of gravity since General Relativity is only their powerful equations, which in their applications, their results are interpreted arbitrarily. Properties as curvature, viscous fluid, dragging frame and gravity action are attributed mistakenly to the spacetime by the materialist substantivalism, the most credible philosophical interpretation that complements the General Relativity, caused by its absence of physical definition of spacetime and static gravitational field as immaterial, but which violates, the conception of gravity as an effect of coordinates of the generalization of the inertial motion to the accelerated motion and, in particular, the description of the metric tensor of gravity as a geometric field. These properties are really of the quantum vacuum, the main existence form of the matter. In this paper we propose that the quantum vacuum is the source of dark matter and dark energy, therefore, the components of the quantum vacuum are of them. Both are opposite effects of the quantum vacuum that when gravitationally interacts with the cosmic structures, the vacuum it curves and when such interaction tends to cease by declination of the formation of these structures, occurring since near five milliard of years ago, vacuum it maintains quasi plane, since it interacts gravitationally very weakly with itself, accelerating expansion of the universe. (shrink)

In the standard model of cosmology, λCDM, were introduced to explain the anomalies of the orbital velocities of galaxies in clusters highest according estimated by General Relativity the dark matter and the accelerated expansion of the universe the dark energy. The model λCDM is based in the equations of the General Relativity that of the total mass-energy of the universe assigns 4.9% to matter (including only baryonic matter), 26.8%, to dark matter and 68.3% to dark energy adjusted (...) according observed in Planck mission, therefore, excluding bosonic matter (quantum vacuum). However, the composition of dark matter and dark energy are unknown. Due to that it lacks of a correct physical theory of gravity since General Relativity is only their powerful equations, which in their applications, their results are interpreted arbitrarily. Properties as curvature, viscous fluid, dragging frame and gravity action are attributed mistakenly to the spacetime by the materialist substantivalism, the most credible philosophical interpretation that complements the General Relativity, caused by its absence of physical definition of spacetime and static gravitational field as immaterial, but which violates, the conception of gravity as an effect of coordinates of the generalization of the inertial motion to the accelerated motion and, in particular, the description of the metric tensor of gravity as a geometric field. These properties are really of the quantum vacuum, the main existence form of the matter. In this paper we propose that the quantum vacuum is the source of dark matter and dark energy, therefore, the components of the quantum vacuum are of them. Both are opposite effects of the quantum vacuum that when gravitationally interacts with the cosmic structures, the vacuum it curves and when such interaction tends to cease by declination of the formation of these structures, occurring since near five milliard of years ago, vacuum it maintains quasi plane, since it interacts gravitationally very weakly with itself, accelerating expansion of the universe. (shrink)

This paper continues and extensive exploration of the QG and TOE resulting from the PF interpretation of QM. Some highlights are an exploration of symmetries of the Standard Model, outlines of testable predictions of implications for QG, that this theory can simultaneously give an account of dark matter and dark energy, probabilities and statevector collapse vs. gravity, applications of the causal interaction tensor Cαβγδ(Fi, Fj). Note the first section mentions qualia but this is not a psychological theory this (...) is an ontic theory. (shrink)

When this article was first planned, writing was going to be exclusively about two things - the origin of life and human evolution. But it turned out to be out of the question for the author to restrict himself to these biological and anthropological topics. A proper understanding of them required answering questions like “What is the nature of the universe – the home of life – and how did it originate?”, “How can time travel be removed from fantasy and (...) science fiction, to be made scientific and practical?”, and “How can the proposed young age of genus Homo be made to actually be reasonable – when simply stating it would be solid ground for instant rejection and dismissal?” The result is that the article also talks about subjects like Artificial Intelligence, General Relativity, and cosmology. -/- From where did life originate? God? Evolution? Panspermia? If the tendency of humans and scientists to regard undiscovered science as pseudoscience can be overcome, Einstein gave another alternative to consider when he introduced General Relativity. Time isn’t linear – progressing in a straight line from past to present to future. That assumption ignores Relativity which states that space AND TIME are curved. Where did life and the genetic code come from? Can the answer build AI? -/- The first question can be answered by the section of this article titled SETI, Evolution, and Time which says life (possibly multicellular and intelligent) and the genetic code came from humans acquiring knowledge of these things over the centuries, then applying that knowledge – via terraforming, accumulation of raw materials like amino acids and nucleic acids, genetic engineering - to a time in the past when life didn’t exist. From that origin, life evolved through innumerable mutations and adaptations, with humans once again acquiring knowledge of it in cyclic (nonlinear) time. -/- The second question is answered by saying artificial intelligence (AI) as the product of life is only half of the equation. The other half refers to Relativity’s curved space-time and violation of the notion that time always travels from past to future. We have always lived in an artificially intelligent, non-probabilistic universe where everything in time and space is connected into one thing by quantum entanglement – making the brain and genes products of binary-digit activity or artificial intelligence (life is not merely dependent on biology’s “lock and key” mechanisms but also possesses AI). -/- The earliest documented representative of the genus Homo is Homo habilis, which evolved around 2.8 million years ago. Scientists used to believe there was a straight line from H. habilis to us, Homo sapiens. This article will use the “advanced” waves loved by Physics Nobel laureate Richard Feynman, view the history of science through the lens of Conic Sections applied to Relativity’s curved space-time, and incorporate the necessity of so-called imaginary time * – popularized by Prof. Stephen Hawking. While the evolutionary proposals are more in agreement with this early straight line than with modern theories, Albert Einstein’s General Relativity is used to transform the straight line into a curved line, ultimately concluding that Homo habilis (H. habilis) originated only (and unbelievably, as far as today’s science and technology is concerned) ~250,000 years ago. Other branches and dead ends of Homo – e.g. Neanderthals – are the result of mutations and adaptations, with the resultant modifications to anatomy and physiology. The surprisingly young age of H. habilis allows nearly 200,000 years for habilis, or one of its descendants, to reach Australia … if this country’s indigenous Aboriginal population did, as claimed, reach this “island continent” 60,000 years ago. -/- * The ultraviolet catastrophe, also called the Rayleigh–Jeans catastrophe, is a failure of classical physics to predict observed phenomena: it can be shown that a blackbody - a hypothetical perfect absorber and radiator of energy - would release an infinite amount of energy, contradicting the principles of conservation of energy and indicating that a new model for the behaviour of blackbodies was needed. At the start of the 20th century, physicist Max Planck derived the correct solution by making some strange (for the time) assumptions. In particular, Planck assumed that electromagnetic radiation can only be emitted or absorbed in discrete packets, called quanta. Albert Einstein postulated that Planck's quanta were real physical particles (what we now call photons), not just a mathematical fiction. From there, Einstein developed his explanation of the photoelectric effect (when quanta or photons of light shine on certain metals, electrons are released and can form an electric current). So it appears entirely possible that another supposed mathematical trickery (imaginary time and the y-axis of Wick rotation) will find practical application in the future. -/- The article includes mathematical references to cosmology (spoiler alert – you’ll read about things like Vector-Tensor-Scalar Geometry, topology, the “eternal present”, Einstein’s Unified Field, the inverse-square law, and there being no Big Bang and no multiverse - but there will also be no equations). -/- The other subheadings in this essay are – -/- NONLINEAR TIME AND ELECTRICAL ENGINEERING (about a 2009 electrical engineering experiment at America’s Yale University, and cosmic wormholes) -/- BITS AND TOPOLOGY (base-2 maths aka Binary digiTS, Mobius strips, and figure-8 Klein bottles) -/- WICK ROTATION, CAUSALITY, AND UNITING TIME (do past, present and future co-exist in an “eternal present”?) -/- DIGITAL BRAIN, DIGITAL UNIVERSE (if the brain and the universe are ultimately composed of binary digits, we'll someday be able to do the same things with the brain and universe that we now do with computers) -/- PROPOSAL: HUMAN AND ANIMAL INSTINCTS ARE THE RESULT OF THE UNIVERSE BEING UNIFIED BY BINARY DIGITS (AND TOPOLOGY) (If everything in the universe is ultimately composed of electronic BITS, then the universe must possess Artificial Intelligence - some prefer the term Cosmic Consciousness) -/- INFORMATION THEORY CONQUERS A RED GIANT (preserving Earth by keeping the Sun near today’s level of activity forever). 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This work is a attempt to describe various braches of mathematics and the analogies betwee them. Namely: 1) Symbolic Analogic 2) Lateral Algebraic Expressions 3) Calculus of Infin- ity Tensors Energy Number Synthesis 4) Perturbations in Waves of Calculus Structures (Group Theory of Calculus) 5) Algorithmic Formation of Symbols (Encoding Algorithms) The analogies between each of the branches (and most certainly other branches) of mathematics form, ”logic vectors.” Forming vector statements of logical analogies and semantic connections between the di↵erentiated (...) branches of math- ematics is useful. It’s useful, because it gives us a linguistic notation from which we can derive other insights. These combined insights from the logical vector space connections yield a combination of Numeric Energy and the logic space. Thus, I have derived and notated many of the most useful tangent ideas from which even more correlations and connections ca be drawn. Using AI, these branches can be used to form even more connections through training of lan- guage engines on the derived models. Through the vector logic space and the discovery of new sheaf (Limbertwig), vast combinations of novel, mathematical statements are derived. This paves the way for an AGI that is not rigid, but flex- ible, like a Limbertwig. The Limbertwig sheaf is open, meaning it can receive other mathematical logic vectors with di↵erent designated meanings (of infi- nite or finite indicated elements). Furthermore, the articulation of these syntax forms evolves language away from imperative statements into a mathematically emotive space. Indeed, shown within, we see how the supramanifold of logic is shared with the supramanifold of space-time mathematically. Developing clean mathematical spaces can help meditation, thought pro- cess, acknowledgment of ideas spoken into that cognitive-spacetime and in turn, methods by which paradoxes can be resolved linguistically. This toolkit should be useful to all in the sciences as well as those bridging the humantities to mathematics. Using our memories as a toolkit to aggregate these ideas breaks down bound- aries between them in a new, exciting way. Merging philosophy and Quantum Mechanics together through the lens of symbolic analogies gives the tools to unravel this mystery of all mysteries. Mathematics thus exists as a bridge al- beit a complex one between the two disciplines, giving life to a composite art of problem-solving. Furthermore, mathematics yields to millions of other applications that are potentially limited only by our imagination. From massive data sets used for predictive analytics to emerging fields in medicine, mathematics is an energy and force at the center of possibilities. The power of mathematics to help manage life exists in its ability to shape and model the world in which we live and interact with one another. In conclusion, mathematics is a powerful tool that creates bridges and con- nections between many disciplines and serves as a powerful form of analytical data consumption. It provides language-rich bridges from which to assemble vast fields of theoretical investigations and create groundbreaking innovations. As we approach new horizons in the technology timeline, mathematics will con- tinue to be a powerful driver of creativity and progress. (shrink)

This article’s conclusion is that the theories of Einstein are generally correct and will still be relevant in the next century (there will be modifications necessary for development of quantum gravity). Those Einsteinian theories are Special Relativity, General Relativity, and the title of a paper he published in 1919 which asked if gravitation plays a role in the composition of elementary particles of matter. This paper was the bridge between General Relativity and the Unified Field Theory he sought during the (...) last 25 years of his life. In an article published in the "Annals of Physics" in 1957, Charles Misner and John Wheeler claimed that Einstein's latest equations demonstrated the unified field theory. But Einstein himself felt he had not fully succeeded. The present article begins with Olbers’ paradox (why is the sky dark at night?) Then it briefly proceeds to the subjects of Newtonian gravity, quantum entanglement, gravitational waves, E=mc^2, dark energy, dark matter, cosmic expansion, redshift, blueshift, the cosmic microwave background, the 1st Law of Thermodynamics, and explanation of advanced waves travelling back in time. The section “vector-tensor-scalar geometry” touches on mass, quantum spin, the Higgs boson and Higgs field, stellar jets, the pervasiveness of photons and gravitons, and supersymmetry. Then come half a dozen paragraphs referring to formation of planets, black holes, and bosons of the weak and strong nuclear forces. They end with Descartes’ space-matter relation. Also added are paragraphs about simply-connected mathematics, non-orientability, consciousness, the Law of Falling Bodies, the multiverse, space-time travel developed from maths’ Brouwer Fixed Point Theorem and from an experiment in electrical engineering performed at Yale University, development from future space-time travel of human flight in the manner of fiction’s Superman and Supergirl, as well as downloaded band-gap implants in the brain that could deal with forms of matter. They could add or delete anything and everything we choose by emulating computers’ copy/paste function to add things; as well as their delete function, to remove things. To complete my seemingly unusual ideas, 6 sections are added – 1) “Advanced and Retarded Waves” is extended to include dinosaurs, ageing, and photography, 2) there’s a bit about space-time warping and “imaginary” computers, 3) several paragraphs about restoring health (even gaining immortality) by using gravity, 4) a section about superconductivity and the electric or magnetic fields of planets (this section mentions Mercury, Planet 9 and precession), 5) a section titled EXPLAINING OCEAN TIDES WHEN GENERAL RELATIVITY SAYS GRAVITY IS A PUSH CAUSED BY THE CURVATURE OF SPACE-TIME (this has subsections about M-Sigma, Geysers on Saturn’s Moon Enceladus, and A Brief History of Gravity), plus 5) the potential of COVID-19 to create the Golden Rule, world peace, eternal life, and a non-economic world that doesn’t use any form of money (no cash, credit cards, digital currency, etc.) The final section is called DISTANT-FUTURE SCIENCE INTERPRETED BY RELIGIONS AS SUPERNATURAL and introduces an idea for becoming immortal in these physical bodies. If the Theory of Everything sought by physicists applies to all space-time, then every person’s brain must be entangled with the 22nd century (and far beyond that time too). (shrink)

This paper addresses the issues related to designing and estimating the strength of solid-alloy elements in the deforming broaches of significant diameter (exceeding 150 mm) for the developed process of discrete broaching. The tool limit condition was assessed based on two strength criteria: the specific potential energy of shape change and the maximum tangent stresses. Numerical modeling using the finite element method has made it possible to derive the distribution of equivalent stresses in the tool elements and the contact (...) stresses at the surface of the contact between a solid-alloy insert and the body, which enabled the analysis of tool strength under loading. The simulation was performed under a single normal load, which ensured the versatility of the calculation for any contact pressure values. We have derived formulae to calculate the acceptable contact pressure depending on unit load. The effect of the insert protrusion height over the body on the strength of tool elements has been established. We have derived engineering dependences that determine the required magnitude of insert protrusion over the body depending on the ultimate load. An example of calculating the strength of a prefabricated deforming element in the machining of a sleeve made from gray modified cast iron of hardness HB230 has been considered. Our calculations have shown that the deforming element designed for the new technological process corresponds to the conditions of strength, provided the ratio h1/h=0.15 is maintained (where h1 is the insert height above the body, h is the insert height). The results obtained could be used in engineering calculations when designing the prefabricated tool for discrete deformation, as well as to assess the strength of prefabricated tools, such as cutters, core drills, reamers, when refining external loads. (shrink)

A philosophical exploration is presented that considers entities such as atoms, electrons, protons, reasoned (in existing physics theories) by induction, to be other than universal building blocks, but artifacts of a sociological struggle that in elemental description is identical with that of all processes of matter and energy. In a universal context both men and materials, when stressed, struggle to accomplish/maintain the free state. The space occupied by cognition, inferred to be the result of the inequality of spaces, is (...) an integral component of both processes and process interpretation; arbitration space, ubiquitous throughout nature, occurred to a vast number of vastnesses, a manifestation of the existence of time dependent mass/number/amount, is argued to be located to the same judging criteria with which principles are determined for sociological purposes: the processes of mind are determined (excuse the pun) to occur as a free state that is reflectively equal to what is construed by the intellect as universe. Scientifically determined states are not free states. (shrink)

We address a long-standing debate over whether classical magnetic forces can do work, ultimately answering the question in the affirmative. In detail, we couple a classical particle with intrinsic spin and elementary dipole moments to the electromagnetic field, derive the appropriate generalization of the Lorentz force law, show that the particle's dipole moments must be collinear with its spin axis, and argue that the magnetic field does mechanical work on the particle's elementary magnetic dipole moment. As consistency checks, we calculate (...) the overall system's energy-momentum and angular momentum, and show that their local conservation equations lead to the same force law and therefore the same conclusions about magnetic forces and work. We also compute the system's Belinfante-Rosenfeld energy-momentum tensor. (shrink)

The first purpose of this series of articles is to introduce case studies on how current AI models can be used in the development of a possible theory of quantum gravity, their limitations, and the role the researcher has in steering the development in the right direction, even highlighting the errors, weaknesses and strengths of the whole process. The second is to introduce the new Presentist Fragmentalist ontology as a framework and use it for developing theories of quantum gravity and (...) speculate on achieving a TOE. We emphasize it is necessary for the researcher to check everything in these articles for themselves. While there are many good ideas in this series of papers, the AI is known to make even arithmetic and algebraic mistakes. To select just five apparently good ideas, there is a causal interaction tensor Cαβγδ(F1, F2) that encodes the causal relationship and the strength of the (possibly non-local) interaction between two fragments of reality (formed by each quantum system). There is a quantitative prediction for a testable table-top experiment. There is an explanation of how spacetime emerges from the fragments and their interactions. There is an explicit account of the double-slit experiment. And there is an explanation how this theory accommodates dark matter and dark energy simultaneously. We explore ideas, equations they lead to, concrete calculations, and give corrections along the way. While these are generally morally right within this framework they must be checked by the researcher. Given this caveat, we believe we have made significant progress with the PF interpretation in developing a theory of quantum gravity and pointing out a possible path to a TOE. (shrink)

I uncover here a conflict in Kant’s natural philosophy. His matter theory and laws of mechanics are in tension. Kant’s laws are fit for particles but are too narrow to handle continuous bodies, which his doctrine of matter demands. To fix this defect, Kant ultimately must ground the Torque Law; that is, the impressed torque equals the change in angular momentum. But that grounding requires a premise—the symmetry of the stress tensor—that Kant denies himself. I argue that his (...) problem would not arise if he had kept his early theory of matter as made of mass points, or “physical monads.”. (shrink)

The soul is believed to be an immortal essence of living things in scores of philosophical and religious traditions but sparsely understood by science. The word ‘soul’ does not have a scientific definition but through this paper is hypothesized to be an indefinite, non-structured, massless energy made up of electromagnetic radiations that is confined in the cytoskeletal network of the biological cell. Electromagnetic radiations continually interact with the biological cell and propagate within the cell; by a pathway known as (...) ‘Cell-Soul Pathway’. This pathway is a coherent, imperceptible, uncontainable and recyclable support pathway, which uses this energy to promulgate consciousness in a biological cell. The cell-soul pathway augments with stress and ceases with death and results in, liberation of the energy as ultra-weak electromagnetic radiations that coalesce with the universe. The cell-soul pathway creates a strong correlation between science and consciousness, and with religion and spirituality. (shrink)

To enable microbial colonisation of the gut mucosa, the intestinal immune system must not only react to danger signals but also recognize cues that indicate safety. Safety recognition, paradoxically, is mediated by the same environmental sensors that are involved in signalling danger. Indeed, in addition to their well established role in inducing inflammation in response to stress signals, pattern recognition receptors (PRRs) and a variety of metabolic sensors also promote gut-microbiota symbiosis by responding to "microbial symbiosis factors", "resolution-associated molecular (...) patterns", markers of energy extraction and other signals indicating the absence of pathogenic infection and tissue damage. Here we focus on how the paradoxical role of immune receptors and other environmental sensors define the microbiota signature of the individual. (shrink)

Henry Shue’s latest book, The Pivotal Generation: Why We Have a Moral Responsibility to Slow Climate Change Right Now, is an excellent read, both clear and comprehensive. It is written in a way that makes it accessible to philosophers and non-philosophers alike. The book argues persuasively that the people alive today must take immediate and drastic action to tackle climate change, as the current decade will be crucial for determining how severe the impacts will become. Shue warns how a sharp (...) division into past, present, and future is misleading when it comes to climate change and can obfuscate the extent of the responsibility that the current generations bear. For us to acknowledge our responsibility, we must recognise how deeply intertwined our lives are with both the past and the future. One of these innate deep connections between generations is the extensive time period that carbon emissions can continue to contribute to climate change, for dozens of centuries. -/- The current generations have been bequeathed an energy system that relies on fossil fuels and that continues to add greenhouse gases to the atmosphere. For over two centuries now, the planet has been getting warmer as an unintended side effect of industrialisation. We are the first humans to understand the dynamics of the Earth’s climate and how human actions cause anthropogenic climate change. With the rapidly advanced scientific knowledge, it has become apparent that there is a need to quickly transition to a different energy regime. Shue points out that this knowledge has made us the first humans to recognise that action is required, but the urgency of the problem also makes us possibly the last to still be able to act before certain major threats are aggravated. With many irreversible climate change impacts, the date-of-last-opportunity to take action to prevent them might be very soon. According to Shue (2021, p. 6), “This gives us an awesome responsibility. Humans have accidentally set our own house on fire, and if we do not douse the flames while they are no more extensive than they are now, it may not be possible ever to extinguish them”. That is why we alive now are the pivotal generation. -/- Although a sense of urgency runs through the book and the seriousness of the situation is made very clear, Shue steers away from fearmongering. He does not think that human extinction is around the corner, but underlines that we cannot rule out such threats until we stop feeding the beast. Unless we cap emissions at a relatively safe level and transform our infrastructure to net zero, we will keep on increasing risks to future people by “adding continuously to the mushrooming danger” (p. 23). The book stresses that the possibility of passing several tipping points adds to the urgency and the risks because when positive feedback mechanisms are triggered, climate change accelerates. These positive feedbacks can feed into each other, such as when warming seawater melts even more ice, with the possibility of a cascade of feedbacks if enough tipping points are passed. Such changes are irreversible and could themselves become further positive feedbacks. Shue (pp. 24–25) warns that it is “likely that the near future is the last chance to avoid passing significant tipping points and entirely possible that the near future is the last chance to avoid provoking a cascade of tipping points” (emphasis in original). -/- While I applaud the general message of Shue’s book, I find that the brushstrokes he uses when identifying those responsible are a little too broad. The reason for this is twofold. Firstly, it is questionable as to how many of us really know enough about the risks we are leaving future generations with. Secondly, discussion in terms of generations underplays the big differences between the responsibility of different groups of actors within them. In what follows, I will elaborate on these points. I should note from the outset, however, that although I think that these are important issues, I find them to be points of clarification in an impressive and ambitious book on why our actions have such significance and why objections to urgent, large-scale climate action are misplaced. (shrink)

Influenza virus (H1N1) caused seasonal influenza, is an acute respiratory infection that spreads to whole worldwide. The first case of influenza A virus pandemics in India came to light in May 2009 in Hyderabad city of Telangana. Human-to-human transmission led to considerable morbidity and mortality within the country until December.The total number of seasonal influenza cases in India from the year 2010 to 31st July 2020 is 1,73,488. Decreasing ambient temperature is often associated with influenza weather. The viral particle's ability (...) to survive long term in cold temperatures also plays an important role. Besides, coagulation during winter serves as a co-contributing factor in facilitating the spread of the influenza virus. The environmental temperature leads to physical stress and energy loss due to thermal regulation, which weakens the immune system and thereby increases the host's likelihood of infection. The prevention of epidemics in India was possible only by quick and efficient measures taken by the Government.Soon after cases were registered at Pune, Maharashtra, and other places across the country, steps were taken to revise the guidelines for the control of the disease in India.Classification of cases in health facilities and home environments, classification of cases, providing treatment to appropriate persons, public education, and other appropriate measures proved to be very effective in due course of time. In this paper, we discussed the total cases and mortality due to seasonal influenza virus in the states and union territories in India from the year 2010 to the year 2020. (shrink)

Buildings energy consumption is growing gradually and put away around 40% of total energy use. Predicting heating and cooling loads of a building in the initial phase of the design to find out optimal solutions amongst different designs is very important, as ell as in the operating phase after the building has been finished for efficient energy. In this study, an artificial neural network model was designed and developed for predicting heating and cooling loads of a building (...) based on a dataset for building energy performance. The main factors for input variables are: relative compactness, roof area, overall height, surface area, glazing are a, wall area, glazing area distribution of a building, orientation, and the output variables: heating and cooling loads of the building. The dataset used for training are the data published in the literature for various 768 residential buildings. The model was trained and validated, most important factors affecting heating load and cooling load are identified, and the accuracy for the validation was 99.60%. (shrink)

Everywhere in the world, and in every period of human history, it has been common for energy decisions to be made in an ethically haphazard manner. With growing population pressure and increasing demand for energy, this approach is no longer viable. We believe that decision makers must include ethical considerations in energy decisions more routinely and systematically. To this end, we propose an applied ethics framework that accommodates principles from three classical ethical theories—virtue ethics, deontology, consequentialism, and (...) two Native American ethics (Lakota and Navajo)—all considered from the perspectives of the impacted communities. We illustrate this framework by evaluating five recent energy decisions: the Dakota Access Pipeline, the Navajo Nation’s possible transition from coal to solar, hydraulic fracturing in Pennsylvania, uranium mining in Virginia, and the construction of the Xiaolangdi Dam in China. An applied ethics framework is preferable to existing ethical analyses because it can serve to sharpen arguments for (un)ethical decisions and action. Rather than treat ethical reasoning as a matter of opinion, we argue that applying ethical principles in a universal and standardized way adds rigor to energy sector decisions by presenting a position available for objective scrutiny. Because our framework identifies which aspects of a targeted action (if any) must adjust to improve ethical merit, it can serve as a practical tool for improving decision-making as we enter a new era of energy transitions. (shrink)

Effective stress management strategies correlate with improved academic performance in college students, yet inconsistent findings in existing research warrant further investigation. This study explored the intricate interplay between stress levels, coping strategies, and academic achievement in HyFlex learningenvironments. A stratified random sample of 111 students from five specializations within the Bachelor of Secondary Education program participated. Utilizing a descriptive-correlational design, data were collected through validated self-report questionnaires and a weighted general average. Subsequent descriptive statistics and bivariate correlation analysis (...) revealed moderate stress levels among participants who preferred task-oriented coping strategies. Interestingly, a significant positive association was observed between stress levels and academic achievement and emotion-oriented coping strategies, while a negative correlation emerged between stress and task-oriented coping strategies. Avoidance-oriented coping strategies, conversely, displayed a significant negative association with academic success. These findings underscore the crucial role of educational institutions in providing robust support mechanisms for stress management and cultivating a task-focused learning environment to optimize student well-being and academic performance within the HyFlex model. (shrink)

Throughout the history of mankind, energy security has been always seen as a means of protection from disruptions of essential energy systems. The idea of protection from disorders emerged from the process of securing political and military control over energy resources to set up policies and measures on managing risks that affect all elements of energy systems. The various systems placed in a place to achieve energy security are the driving force towards the energy (...) innovations or emerging trends in the energy sector. Our paper discusses energy security status and innovations in the energy sector in European Union (EU). We analyze the recent up-to-date developments of the energy policy and exploitation of energy sources, as well as scrutinize the channels of energy streaming to the EU countries and the risks associated with this energy import. Moreover, we argue that the shift to the low-carbon production of energy and the massive deployment of renewable energy sources (RES) might become the key issue in ensuring the energy security and independency of the EU from its external energy supplies. Both RES, distributed energy resources (DER) and “green energy” that will be based on the energy efficiency and the shift to the alternative energy supply might change the energy security status quo for the EU. (shrink)

Achieving energy sovereignty is increasingly gaining prominence as a goal in energy politics. The aim of this paper is to provide a conceptual analysis of this principle from an ethics and social justice perspective. We rely on the literature on food sovereignty to identify through a comparative analysis the elements energy sovereignty will most likely demand and thereafter distinguish the unique constituencies of the energy sector. The idea of energy sovereignty embraces a series of values, (...) among which we identified: (i) accessibility, to allow access to everyone, (ii) empowerment and recognition, to develop and sustain capabilities to collaboratively produce solution-oriented energy system knowledge and effectively participate in governance, (iii) stewardship and sustainability, to be able to design and manage decentralised renewable systems in view of protecting the environment, (iv) self-sufficiency, to reduce the negative shocks of exploitative business practises, (v) resilience, to maintain production capacities while withstanding socioeconomic, political, environmental and climatic shocks, (vi) peace, to establish production systems that do not involve hostile relations, (vii) transparency and self-determination, to establish democratic decision-making mechanisms that give a voice to previously underrepresented groups and limit corporate takeover (viii) gender-justice, by acknowledging the contributions of women and eliminate barriers to their empowerment. With a conceptual framework of energy sovereignty, we present a rationale that draws on the key values to be considered when formulating policy solutions for the energy sector. (shrink)

Over the last fifteen years, an ambitious explanatory framework has been proposed to unify explanations across biology and cognitive science. Active inference, whose most famous tenet is the free energy principle, has inspired excitement and confusion in equal measure. Here, we lay the ground for proper critical analysis of active inference, in three ways. First, we give simplified versions of its core mathematical models. Second, we outline the historical development of active inference and its relationship to other theoretical approaches. (...) Third, we describe three different kinds of claim -- labelled mathematical, empirical and general -- routinely made by proponents of the framework, and suggest dialectical links between them. Overall, we aim to increase philosophical understanding of active inference so that it may be more readily evaluated. -/- This the final submitted version of the Introduction to the Topical Collection "The Free Energy Principle: From Biology to Cognition", forthcoming in Biology & Philosophy. (shrink)

Building information modeling can help in predicting the energy efficiency in future based on dynamic patterns obtained by visualization of data. The aim of this study was to investigate the effective parameters of energy consumption using BIM technology which can evaluate the buildings energy performance. First, three forms of general states in the building were modeled to evaluate the proposed designs in Autodesk Revit Software. Then, the main building form for energy modeling and analysis was selected. (...) Autodesk Revit 2020 software was also used to obtain the results of climate data analysis and building energy consumption index. Finally, the most optimal mode was selected by examining different energy consumption modes. The results showed that the use of building information modeling technology in adjusting the parameters affecting energy consumption can save energy cost up to 58.23% in block D. Energy cost savings for block C and the western lobby were obtained as 51.03% and 43.05%, respectively. Based on energy use intensity, energy cost savings for blocks C, D, and the western lobby were estimated as 16.67%, 16.30%, and 11%, respectively. The results of parametric studies on alternative schemes of energy use intensity optimization showed that 16.30% savings could be achieved by the base building model in a 30-year time horizon. Therefore, it was concluded that optimization of energy consumption would reduce the environmental pollutants emission and contribute to preservation and sustainability of the environment. (shrink)

We study the conservation of energy, or lack thereof, when measurements are performed in quantum mechanics. The expectation value of the Hamiltonian of a system changes when wave functions collapse in accordance with the standard textbook treatment of quantum measurement, but one might imagine that the change in energy is compensated by the measuring apparatus or environment. We show that this is not true; the change in the energy of a state after measurement can be arbitrarily large, (...) independent of the physical measurement process. In Everettian quantum theory, while the expectation value of the Hamiltonian is conserved for the wave function of the universe, it is not constant within individual worlds. It should therefore be possible to experimentally measure violations of conservation of energy, and we suggest an experimental protocol for doing so. (shrink)

Somatic diversification of antigen receptor genes depends on the activity of enzymes whose homologs participate in a mutagenic DNA repair in unicellular species. Indeed, by engaging error-prone polymerases, gap filling molecules and altered mismatch repair pathways, lymphocytes utilize conserved components of genomic stress response systems, which can already be found in bacteria and archaea. These ancient systems of mutagenesis and repair act to increase phenotypic diversity of microbial cell populations and operate to enhance their ability to produce fit variants (...) during stress. Coopted by lymphocytes, the ancient mutagenic processing systems retained their diversification functions instilling the adaptive immune cells with enhanced evolvability and defensive capacity to resist infection and damage. As reviewed here, the ubiquity and conserved character of specialized variation-generating mechanisms from bacteria to lymphocytes highlight the importance of these mechanisms for evolution of life in general. (shrink)

According to the BSM- Supergravitation Unified Theory (BSM-SG), the energy is indispensable feature of matter, while the matter possesses hierarchical levels of organization from a simple to complex forms, with appearance of fields at some levels. Therefore, the energy also follows these levels. At the fundamental level, where the primary energy source exists, the matter is in its primordial form, where two super-dense fundamental particles (FP) exist in a classical pure empty space (not a physical vacuum). They (...) are associated with the Planck scale parameters of frequency and distance and interact by Supergravitational forces. These forces are inverse proportional to the cube of distance at pure empty space and they are based on frequency interactions. Since the two FPs have different intrinsic frequencies, the SG forces appear different for interactions between the like and unlike FPs and may change the sign. This primordial form of matter exists in the super-heavy black holes located in the center of each well formed galaxy. The next upper level of matter organization includes the underlying structure of the physical vacuum, called a Cosmic Lattice, and the structure of elementary particles. They have common substructure elements obtained by specific crystallization process preceding the formation of the observable galaxies. The Cosmic Lattice, forming a space known as a physical vacuum, is responsible for the existence and propagation of the physical fields: electrical, magnetic, Newtonian gravity and inertia. The energy of physical vacuum is in two forms: Static (enormous) and Dynamic (weak). The Static energy is directly related to the Newtonian mass by the Einstein equation E = mc^2 and it is a primary source of the nuclear energy. The Dynamic energy is responsible for the existence of the electric and magnetic fields, the constant speed of light and the quantum mechanical properties of the physical vacuum. The next upper energy level is the dynamical energy of excited atoms and molecules. At this level a hidden energy wells exit, such as the internal energy of the electron and the internal energy of atoms with more than one electron. The next upper energy level is at some organic molecules and particularly in the biomolecules that contain ring atomic structures. In such a structure, some quantum states are not emitted immediately, but rotating in the ring. While in organic molecules the energy stored in such a ring is released by a chemical process, in the long chain molecule of proteins in the living organism the stored energy can be released simultaneously by triggering. A huge number of atomic rings are contained in the DNA strands. The release of the energy stored in DNA, for example, is an avalanche process that causes an emission of entangled photons possessing a strong penetrating capability. A sequence of entangled photons emitted by DNA should carry the genetic information encoded by the cordons. This mechanism, predicted in BSM-SG theory, is very important for intercommunication between the cells of the living organism. The next upper level of energy organization may exist in the brain. The brain is an organ of a most abundant number of atomic rings, while its tissue environment might permit complex energy interactions. The human brain contains billions of atomic rings. The next hypothetical upper level of energy organization is an information field, physically existed outside, but connected with the living brain. It corresponds to a specific field known as aura, while the possibility of its existence is still not accepted by the main stream science. The problem is that this field could not be detected by the currently existing technical means used for EM communications. The BSM-SG predicts that this field might differ from the EM field we use for communication, but it is a subject of a further theoretical development that must be supported by experiments using specifically designed technical means. According to the BSM-SG theory, the energy conversion from the primary energy source to the complex levels of matter and field organization is a permanent syntropic process based on complex resonance interactions. (shrink)

This chapter conceptually analyzes the post-traumatic stress injuries called moral injury, moral fatigue or exhaustion, and broken spirit. It then identifies two puzzles. First, soldiers sometimes sustain moral injury even from doing right actions. Second, they experience moral exhaustion from making decisions even where the morally right choice is so obvious that it shouldn’t be stressful to make it; and even where rightness of decision is so murky that no decision could be morally faulted. The injuries result of mistaken (...) moral self-evaluation. Methods of preventing and treating these injuries are defended, including training in self-forgiveness, moral off-loading of actions and decisions to persons and devices less likely to feel inappropriate guilt, and the use of drugs to prevent such guilt. The foregoing has been about moral injury erroneously resulting from the non-violation of a correct moral code. But the chapter then introduces the concept of moral pseudo-injury—felt moral injury that has in reality resulted from violation of a false moral code, so that no one has really been morally injured. This can be used as a method in warfighting. And since the injuries it produces are illusory, this would be morally superior to physical violence. For it causes less injury to its victims, and should cause less guilt in those who must inflict it. Historical precedents are considered. Finally, our enemies often use moral pseudo-injury against us, in the form of terrorist violence against civilians. Terrorism causes comparatively few harms, yet we mistakenly see it as more morally horrific than conventional combat that causes much worse loss of life among armed forces members. Here we need the nuancing and clarifying power of philosophy to restore a sense of proportion, thence to prevent or therapize the moral pseudo-injury we may experience from these sorts of attacks. (This is a pre-penultimate version of the published version, available from OUP at the external link, which contains minor variances. The paper was earlier known as "PTSD Weaponized: A Theory of Moral Injury"; that now superseded version is archived under "past conferences" on the Center for Ethics and the Rule of Law website.). (shrink)

This work addresses the autonomous organization of biological systems. It does so by considering the boundaries of biological systems, from individual cells to Home sapiens, in terms of the presence of Markov blankets under the active inference scheme—a corollary of the free energy principle. A Markov blanket defines the boundaries of a system in a statistical sense. Here we consider how a collective of Markov blankets can self-assemble into a global system that itself has a Markov blanket; thereby providing (...) an illustration of how autonomous systems can be understood as having layers of nested and self-sustaining boundaries. This allows us to show that: (i) any living system is a Markov blanketed system and (ii) the boundaries of such systems need not be co-extensive with the biophysical boundaries of a living organism. In other words, autonomous systems are hierarchically composed of Markov blankets of Markov blankets—all the way down to individual cells, all the way up to you and me, and all the way out to include elements of the local environment. (shrink)

The free-energy principle states that all systems that minimize their free energy resist a tendency to physical disintegration. Originally proposed to account for perception, learning, and action, the free-energy principle has been applied to the evolution, development, morphology, anatomy and function of the brain, and has been called a postulate, an unfalsifiable principle, a natural law, and an imperative. While it might afford a theoretical foundation for understanding the relationship between environment, life, and mind, its epistemic status (...) is unclear. Also unclear is how the free-energy principle relates to prominent theoretical approaches to life science phenomena, such as organicism and mechanism. This paper clarifies both issues, and identifies limits and prospects for the free-energy principle as a first principle in the life sciences. (shrink)

Traditionally, building energy model is created in isolation from the architectural building information model and energy analyses have relied on a single analysis tool. The building energy model can be generated more quickly by leveraging existing data from the BIM. The impacts of energy consumption are significant in the building usage phase, which can last several decades. Due to the large share of the final energy consumption in the building sector, accurate analysis of thermal and (...) cooling loads of a building and the efforts to reduce energy losses represent an effective way to reduce energy consumption. Therefore, it is essential to analyze the building energy performance in the design phase, which is when critical decisions are made. This study aims to investigate the impact of the building components and construction materials on building energy efficiency using Building Information Modeling (BIM) technology in a mild climate zone. After reviewing the proposed designs, the main building form was chosen for energy modeling and analysis. Then, building energy consumption analysis was performed based on the basic parameters of the building energy model. Eventually, the most optimal mode was selected by examining different energy consumption forms. This study showed that the building HVAC system always had the largest share of energy consumption. Finally, the results of parametric studies on alternative schemes of energy use intensity optimization showed that 22.59 % savings could be achieved as compared to the base building model in a 30-year time horizon. (shrink)

Purpose: The purpose of this paper is to examine the feasibility and design of zero-energy buildings (ZEBs) in cold and semi-arid climates. In this study, to maximize the use of renewable energy, energy consumption is diminished using passive solar architecture systems and techniques. -/- Design/methodology/approach: The case study is a residential building with a floor area of 100 m2 and four inhabitants in the cold and semi-arid climate, northeast of Iran. For thermal simulation, the climate data such (...) as air temperature, sunshine hours, wind, precipitation and hourly sunlight, are provided from the meteorological station and weather databases of the region. DesignBuilder software is applied for simulation and dynamic analysis of the building, as well as PVsyst software to design and evaluate renewable energy performance. -/- Findings: The simulation results show a 30% decrease in annual energy consumption of the building by complying with the principles of passive design (optimal selection of direction, Trombe wall, shade, proper insulation selection) from 25,443 kWh to 17,767 kWh. Then, the solar energy photovoltaic (PV) system is designed using PVsyst software, taking into account the annual energy requirement and the system’s annual energy yield is estimated to be 26,291 kWh. -/- Originality/value: The adaptive comparison of the values obtained from the energy analysis indicated that constructing a ZEB is feasible in cold and semi-arid conditions and is considered an effective step to achieve sustainable and environmentally friendly construction. (shrink)

According to the United Nations Environment Programme (UNEP), buildings are the largest worldwide consumers of energy. Most of the energy used by any building is consumed during the usage (or operational) stage of the building’s life-cycle. Achieving sustainable development at the national level will require minimizing the effects of buildings on the environment with the low energy consumed by buildings. The energy performance of a given building is predicted and assessed by conducting an energy simulation. (...) Using BIM in EPAs greatly reduces time and costs. The purpose of this study was to optimize energy consumption in buildings, using Building Information Modeling Technology (BIM), which can assess energy performance in the building. In this research, the general form of the building was modeled in the Autodesk Revit Software. After reviewing the proposed designs, the main form of the building was selected for modeling. Then, according to the type of materials consumed, the equipment and location of the project, the calculation of the energy consumption of the building was carried out using relevant tools in this scope. Finally, the best possible mode was chosen by examining different energy consumption modes. The results of energy simulation showed that 61.48% of the difference between the best mode of energy consumption optimization and the current state of the building, as well as 79.35%, is compared to the initial state. Finally, parametric studies of alternative cost optimization schemes showed that saving 58.23% of the building's current status for a 30-year horizon. (shrink)

Technologies lower constraints and expand affordances. As a consequence, they tend to redesign the corresponding space of risks in which agents operate and interact. This paper analyses the concept of metatechnological risk from an ethical perspective, arguing that such an approach is necessary in order to mitigate future global energy crises.

This paper compares the free energy neuroscience now advocated by Karl Friston and his colleagues with that hypothesised by Freud, arguing that Freud's notions of conflict and trauma can be understood in terms of computational complexity. It relates Hobson and Friston's work on dreaming and the reduction of complexity to contemporary accounts of dreaming and the consolidation of memory, and advances the hypothesis that mental disorder can be understood in terms of computational complexity and the mechanisms, including synaptic pruning, (...) that have evolved to reduce it. (shrink)

Buildings are the largest energy consumer worldwide, according to the United Nations Environment Programme (UNEP). Most of the building’s energy consumption is in the building’s life cycle stage. Therefore, achieving sustainable development at the national level requires minimizing the building’s effects on the environment via reducing energy consumption by buildings. The building’s energy performance will be predicted and evaluated by the energy simulation. Using BIM in EPAs significantly reduces time and costs. This study aimed to (...) optimize energy consumption in buildings using Building Information Modeling (BIM) Technology, which can assess energy performance in the building. In this research, the general form of the building was modeled on the Autodesk Revit Software. The main shape of the building was chosen for modeling after reviewing the proposed designs. Then, the building energy consumption was calculated using the relevant tools in this scope, according to the materials, equipment, and project location. Finally, the best possible mode was selected by examining different modes of energy consumption. The results showed that 61.48% difference between the best mode of energy consumption optimization and the current mode of the building and 79.35% compared to the initial mode. Finally, parametric studies of alternative cost optimization schemes showed that saving 58.23% of the building’s current status for a 30-year horizon. (shrink)

Inflammation is activated by diverse triggers that induce the expression of cytokines and adhesion molecules, which permit a succession of molecules and cells to deliver stimuli and functions that help the immune system clear the primary cause of tissue damage, whether this is an infection, a tumor, or a trauma. During inflammation, short-term changes in the expression and secretion of strong mediators of inflammation occur, while long-term changes occur to specific groups of cells. Long-term changes include cellular transdifferentiation for some (...) types of cells that need to regenerate damaged tissue, as well as death for specific immune cells that can be detrimental to tissue integrity if they remain active beyond the boundaries of essential function. The transcriptional regulator NFκB enables some of the fundamental gene expression changes during inflammation, as well as during tissue development. During recurrence of malignant disease, cell stress-induced alterations enable the growth of cancer cell clones that are substantially resistant to therapeutic intervention and to the immune system. A number of those alterations occur due to significant defects in feedback signal cascades that control the activity of NFκB. Specifically, cell stress contributes to feedback defects as it overrides modules that otherwise control inflammation to protect host tissue. NFκB is involved in both the suppression and promotion of cancer, and the key distinctive feature that determines its net effect remains unclear. This paper aims to provide a clear answer to at least one aspect of this question, namely the mechanism that enables a divergent response of cancer cells to critical inflammatory stimuli and to cell stress in general. (shrink)

In the first months of the COVID-19 pandemic, we created and implemented from November 2020 to February 2021 a monthly educational pilot program of philosophical management of stress based on Science, Humanism and Epicurean Pragmatism, which was offered to employees of 26 municipalities in the Prefecture of Attica, Greece. The program named “Philosophical Distress Management Operation System” (Philo.Di.M.O.S.) is novel and unique in its kind, as it combines a certain Greek philosophical tradition (Epicurean) that concurs with modern scientific knowledge. (...) The program was designed to be implemented in a period of crisis; therefore, it used a fast-paced, easy to learn and practice philosophical approach to stress management, based on cognitive psychotherapy. The philosophical approach to stress management has the advantage that it can be offered to most people, regardless of age and educational level. The pilot program was effective in achieving its objectives, shown by statistical comparisons of the trainees’ responses to anonymous questionnaires before and after the month-long training. The successful Philo.Di.M.O.S. program, thus, based on a solid scientific and philosophical basis, offers a paradigm of stress management during crises and could be useful in Greece and internationally. (shrink)

One of the main reasons of environmental pollution is energy consumption in buildings. Today, the use of renewable energy sources is increasing dramatically. Among these sources, solar energy has favorable costs for various applications. This study examined a commercial building in a hot and humid climate. The findings showed that choosing the optimal angle of solar panels with the goal of optimized energy consumption would yield reduced costs and less environmental pollutants with the least cost and (...) maximum energy absorption. In this study, to calculate the energy requirements of the building, DesignBuilder software was used. To study the solar angles and estimate the energy produced by the solar panels, Polysun software was used after simulating the building energy. Energy simulation results showed that the whole building energy consumption was 26604 kWh/year. Finally, the evaluation results of solar panels showed that the energy produced by photovoltaic modules at an optimal angle of 31° would be equal to 26978 kWh/year, which is more than the energy required by the building. This system can prevent 14471 kg of carbon dioxide emissions annually. Sustainable energy criteria showed that for the studied building, photovoltaic modules could be used in energy production to reach a zero-energy system connected to the grid with an annual energy balance. (shrink)

There exist overwhelming – and morally compelling – reasons for shifting to renewable energy (RE), because only that will enable us to timely mitigate dangerous global warming. In addition, several other morally weighty reasons speak in favor of the shift: considerable public health benefits, broader environmental benefits, the potential for sustainable and equitable economic development and equitable energy access, and, finally, long-term energy security. Furthermore, it appears that the transition to RE is economically, technologically, and politically feasible (...) at this point in time. However, there are different possible pathways towards that goal, all of which involve tough choices. Some of these concern different ways of living: Do we have to make a choice between being sustainable and maintaining our current living standard? And if so, how can we balance the value of high living standards against that of a sustainable energy regime? In this chapter, I will not conduct a comprehensive analysis of all available renewable energy technologies, but rather provide a number of examples of tough choices entailed by solar, wind and hydropower. I will also attempt to rebut some of the common misconceptions regarding RE technologies. (shrink)

Private schools are working tirelessly to provide a quality education without support from the government. This article aims to evaluate the internal and external job stress of high school teachers in private schools in Leyte, Philippines, and determine its governing factors. The study involved a complete enumeration process in selecting the participants and gathering primary data. In analyzing and extracting relevant information from the data, standard descriptive metrics, correlation analysis, and Chi-square test for independence were employed with the aid (...) of statistical software. The findings of the study depicted that private teachers are both internally and externally moderately stressful in their jobs. The Chi-square test revealed that employment status and years in service are associated with the private teachers’ internal job stress and it is significant at a 10% level. In addition, it is depicted that gender, monthly salary, and years in service are significantly dependent on the teachers’ external job stress at a 10% level. Conclusively, the school heads and management of private schools must lessen the work assignments to avoid exhaustion and increase benefits to improve the well-being of teachers. Moreover, it is suggested that teachers in private schools must be provided with training and seminars, incentives, supplies for teaching, and other benefits that improve their productivity and become globally competitive educators. (shrink)

I develop a genealogy of the concept of ‘energy’ in western philosophy and science, focusing on how energy concepts (e.g., energeia, vis viva, kinetic/potential energy) have been theorized in relation to time. Looking especially to the ideas of Gilles Deleuze, Henri Bergson, Friedrich Nietzsche, and Martin Heidegger, I argue that the thread that connects energy concepts through time is the epistemological tendency to derive conceptual accounts of change from a prior ontological sameness or essence. I then (...) attempt to lay the groundwork for a process metaphysics that harmonizes with contemporary findings in the physical sciences, while also extending the concept of energy to account for the presence of subjectivity in nature. (shrink)

I argue against Barbara Montero's claim that Conservation of Energy has nothing to do with physicalism. I reject her reconstruction of the argument for physicalism from CoE, and offer an alternative reconstruction that better captures the intuitions of those who believe that there is a conflict between interactionist dualism and CoE.

On edge computing, mobile devices can offload some computing intensive tasks to the cloud so that the time delay and battery losses can be reduced. Different from cloud computing, an edge computing model is under the constraint of radio transmitting bandwidth, power and etc. With regard to most models in presence, each user is assigned to a single mission, transmitting power or local CPU frequency on mobile terminals is deemed to be a constant. Furthermore, energy consumption has a positive (...) correlation with the above two parameters. In a context of multitask, such values could be increased or reduced according to workload to save energy. Additionally, the existing offloading methods are inappropriate if all the compute densities of multiple tasks are high. In this paper, a single-user multi-task with high computing density model is proposed and partial task is offloaded when use the different offload algorithm. Simulated annealing algorithm is the best method to select offloading tasks, which can enhance the offloading ratio and save energy consumption. (shrink)

I begin, haltingly, and the individual begins, for John Stuart Mill, with an impulse. My impulse, in terms of Mill, is to ask after power and energy in his On Liberty. There, impulses are desires and those of the “Strong” variety are synonymous with energy (Mill 2002, p. 62). An individual with their own impulses has character and one with strong impulses governed by a strong will has energetic character. One without them has no character. I begin haltingly, (...) in part, because, insofar as my impulse is directed toward power and energy, I am unsure as to the will that may or may not govern it, whether this question reveals or begins to reveal something of my character, its degree of energy, or the lack thereof. What does it mean, in other words, to ask about power and energy in this book? Call this question the opening of an experiment in thinking. (shrink)

Some multi-path routing algorithm in MANET, simultaneously send information to the destination through several directions to reduce end-to-end delay. In all these algorithms, the sent traffic through a path affects the adjacent path and unintentionally increases the delay due to the use of adjacent paths. Because, there are repetitive competitions among neighboring nodes, in order to obtain the joint channel in adjacent paths. The represented algorithm in this study tries to discover the distinct paths between source and destination nodes with (...) using Omni directional antennas, to send information through these simultaneously. For this purpose, the number of active neighbors is counted in each direction with using a strategy. These criterions are effectively used to select routes. Proposed algorithm is based on AODV routing algorithm, and in the end it is compared with AOMDV, AODVM, and IZM-DSR algorithms which are multi-path routing algorithms based on AODV and DSR. Simulation results show that using the proposed algorithm creates a significant improvement in energy efficiency and reducing end-to-end delay. (shrink)

The relationship between energy and ethics is gaining attention in policy rooms around the world. How does one respond to the competing interests of the environment and posterity while also addressing the energy needs of the present human generation? In Western philosophy, this question is currently subject of debate and research. However, the African philosophical analysis that is required to address this concern is generally absent from discourse/literature on energy ethics. This article aims to bridge this gap, (...) by providing broad analysis that has been lacking from the African context. In a way, it seeks to answer such questions already raised in Western philosophy but from African perspectives. This approach is significant given the fact that Western oriented energy humanities and energy ethics seem to be inappropriate or inadequate to understanding energy dynamics in the African context. Therefore, this paper aims to inform global debate and facilitate African-specific understanding of the complex nexus of human-environment-posterity by building the discourse on Braai filosofie. It discusses specific principles that can be deployed to address trade-offs between ethics and energy, thus providing guide to investment decisions on renewable energy projects in Africa. (shrink)

The European Union (EU) has been experiencing an unprecedented energy crisis for the last 50 years, with severe economic, social and political consequences. Rising energy demand, extreme weather events (unprecedented heat and long winters), disruptions in supply chain and poor regional and global reserves have all contributed to the current energy crisis in the EU. Prices on natural gas in the EU are rising as demand around the world increases. Prices on the gas rose by more than (...) 800 percent year-on-year and prices on the electricity by about 500 percent. Rising prices on gas are due to low stocks in European storage facilities and pressure from Russia, which is trying to speed up the launch of the Nord Stream-2 pipeline. Also in the EU, there is reduction the production of coal and natural gas, reducing the capacity of wind farms. As natural gas plays a significant role in shaping the prices on electricity, electricity has also risen in price. As prices on gas is rose, prices on oil and coal is rose significantly. Demand for energy consumption has also increased due to weather conditions – cold winters and periods of abnormal heat in summer. The largest consumers of gas and electricity in the EU are suffering heavy losses due to rising prices on energy. Industrial giants have begun to cut production, threatening economic recovery. The world economy is recovering from the crisis caused by the coronavirus pandemic, and the EU countries are increasingly in need of energy for industry and the population. An unbalanced transition to renewable energy has become a particular problem for the EU. Calmer weather this year has led to lower energy production using wind turbines. And old European nuclear power plants are gradually being decommissioned. Green energy is not able to cover all needs, so the continent has risen sharply demand on gas. All the above-mentioned problems have certainly affected the further ensure energy security of the EU and require the developing of appropriate mechanisms to overcoming current challenges. (shrink)