Results for 'gene editing'

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  1. Psychology, Character, and Performance in Hamlet.Gene Fendt - 2008 - In Joseph Pearce (ed.), Ignatius Critical Editions: Hamlet. San Francisco, CA, USA: Ignatius Press. pp. 217-230.
    As Shakespeare is closer in time and spirit to medieval psychology than to popular modern explanations of psyche, this article presents a fourfold analysis of ecstasy from Aquinas' Summa Theologiae to examine the characters of the play. I also suggest performance choices which make a variety of these ecstasies of soul more visible.
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  2. Gene Editing, the Mystic Threat to Human Dignity.Vera Lúcia Raposo - 2019 - Journal of Bioethical Inquiry 16 (2):249-257.
    Many arguments have been made against gene editing. This paper addresses the commonly invoked argument that gene editing violates human dignity and is ultimately a subversion of human nature. There are several drawbacks to this argument. Above all, the concept of what human dignity means is unclear. It is not possible to condemn a practice that violates human dignity if we do not know exactly what is being violated. The argument’s entire reasoning is thus undermined. Analyses (...)
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  3. Gene Editing and Journal Editing.Trevor Stammers - 2018 - The New Bioethics 24 (1):1-1.
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  4. Public views on gene editing and its uses.Hub Zwart, George Gaskell & Imre Bard - 2017 - Nature Biotechnology 35 (11):121-123.
    Rapid advances in genome editing and its potential application in medicine and enhancement have been hotly debated by scientists and ethicists. Although it has been proposed that germline gene editing be discouraged for the time being1, the use of gene editing in somatic human cells in the clinical context remains controversial, particularly for interventions aimed at enhancement2. In a report on human genome editing, the US National Academies of Sciences, Engineering, and Medicine (NAS; Washington, (...)
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  5. Great Minds Think Different: Preserving Cognitive Diversity in an Age of Gene Editing.Jonny Anomaly, Julian Savulescu & Christopher Gyngell - 2020 - Bioethics 34 (1):81-89.
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  6. A critical review of the ethical and legal issues in human germline gene editing: Considering human rights and a call for an African perspective.B. Shozi - 2020 - South African Journal of Bioethics and Law 13 (1):62.
    In the wake of the advent of genome editing technology CRISPR-Cas9 (clustered regularly interspaced palindromic repeat (CRISPR)-associated protein 9), there has been a global debate around the implications of manipulating the human genome. While CRISPR-based germline gene editing is new, the debate about the ethics of gene editing is not – for several decades now, scholars have debated the ethics of making heritable changes to the human genome. The arguments that have been raised both for (...)
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  7. Responsible risking, forethought, and the case of germline gene editing.Madeleine Hayenhjelm - 2024 - In Adriana Placani & Stearns Broadhead (eds.), Risk and Responsbility in Context. New York and London: Routledge. pp. 149-169.
    This chapter addresses a general question: What is responsible risking? It explores the notion of "responsible risking" as a thick moral concept, and it argues that the notion can be given moral content that could be action-guiding and add an important tool to our moral toolbox. To impose risks responsibly, on this view, is to take on responsibility in a good way. A core part of responsible risking, this chapter argues, is some version of a Forethought Condition. Such a condition (...)
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  8. Imperfect Methods for Imperfect Democracies: Increasing Public Participation in Gene Editing Debates.Benjamin Gregg - 2023 - American Journal of Bioethics 23 (7):77-79.
    Given some of the various possible impacts of clinical germline editing, we can expect robust disagreement about how best to regulate it. One can point to examples of the promise of editing: “rough...
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  9. Improving the justice‐based argument for conducting human gene editing research to cure sickle cell disease.Berman Chan - 2019 - Bioethics 34 (2):200-202.
    In a recent article, Marilyn Baffoe-Bonnie offers three arguments for conducting CRISPR/Cas9 biotechnology research to cure sickle-cell disease (SCD) based on addressing historical and current injustices in SCD research and care. I show that her second and third arguments suffer from roughly the same defect, which is that they really argue for something else rather than for conducting CRISPR/Cas9 research in particular. For instance, the second argument argues that conducting this gene therapy research would improve the relationship between SCD (...)
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  10. Making Dialogue Work: Responsible Innovation and Gene Editing.Phil Macnaghten, Esha Shah & David Ludwig - forthcoming - In The Politics of Knowledge in Inclusive Development and Innovation.
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  11. Germline edits: Trust ethics review process.Julian Savulescu, Chris Gyngell & Thomas Douglas - 2015 - Nature 520.
    Summary: Edward Lanphier and colleagues contend that human germline editing is an unethical technology because it could have unpredictable effects on future generations. In our view, such misgivings do not justify their proposed moratorium.
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  12. Reasons to Genome Edit and Metaphysical Essentialism about Human Identity.Tomasz Żuradzki & Vilius Dranseika - 2022 - American Journal of Bioethics 22 (9):34-36.
    In this commentary paper, we are taking one step further in questioning the central assumptions in the bioethical debates about reproductive technologies. We argue that the very distinction between “person affecting” and “identity affecting” interventions is based on a questionable form of material-origin essentialism. Questioning of this form of essentialist approach to human identity allows treating genome editing and genetic selection as more similar than they are taken to be in the standard approaches. It would also challenge the idea (...)
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  13. Editing”: A Productive Metaphor for Regulating CRISPR.Ben Merriman - 2015 - American Journal of Bioethics 15 (12):62-64.
    The metaphor of “gene editing” has been employed widely in popular discussions of CRISPR technology. The editing metaphor obscures the physical mechanism of action in CRISPR techniques, and understates the present frequency of off-target effects. However, the editing metaphor may be a useful means to think about approaches to regulating the future use of CRISPR. Conceiving of CRISPR as an information technology recalls the highly computational, information-oriented context of genomic research in which CRISPR has emerged. More (...)
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  14. Reproductive genome editing interventions are therapeutic, sometimes.César Palacios-González - 2021 - Bioethics 35 (6):557-562.
    In this paper I argue that some human reproductive genome editing interventions can be therapeutic in nature, and thus that it is false that all such interventions just create healthy individuals. I do this by showing that the conditions established by a therapy definition are met by certain reproductive genome editing interventions. I then defend this position against two objections: (a) reproductive genome editing interventions do not attain one of the two conditions for something to be a (...)
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  15. Genetic Protection Modifications: Moving Beyond the Binary Distinction Between Therapy and Enhancement for Human Genome Editing.Rasmus Bjerregaard Mikkelsen, Henriette Reventlow S. Frederiksen, Mickey Gjerris, Bjørn Holst, Poul Hyttel, Yonglun Luo, Kristine Freude & Peter Sandøe - 2019 - CRISPR Journal 2 (6):362-369.
    Current debate and policy surrounding the use of genetic editing in humans often relies on a binary distinction between therapy and human enhancement. In this paper, we argue that this dichotomy fails to take into account perhaps the most significant potential uses of CRISPR-Cas9 gene editing in humans. We argue that genetic treatment of sporadic Alzheimer’s disease, breast- and ovarian-cancer causing BRCA1/2 mutations and the introduction of HIV resistance in humans should be considered within a new category (...)
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  16. Bioethics in Canada, second edition.Anthony Skelton (ed.) - 2019 - Don Mills: Oxford University Press.
    This is the second edition of the textbook Bioethics in Canada. It is the most up to date bioethics textbook on the Canadian market. Twenty-nine of its 54 contributions are by Canadians. All the chapters carried over from the first edition are revised in full (especially the chapters on obligations to the global poor, on medical assistance in dying, and on public health). It comprises *new* chapters on emerging genetic technologies and on indigenous peoples' health. It contains *new* case studies (...)
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  17. The trust game CRISPR for human germline editing unsettles scientists and society.Matthias Braun & Darian Meacham - 2019 - EMBO Reports 20 (2).
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  18. Ethical Discourse on Epigenetics and Genome Editing: The Risk of (Epi-) genetic Determinism and Scientifically Controversial Basic Assumptions.Karla Alex & Eva C. Winkler - 2021 - In Michael Welker, Eva Winkler & John Witte Jr (eds.), The Impact of Health Care on Character Formation, Ethical Education, and the Communication of Values in Late Modern Pluralistic Societies. Leipzig: Evangelische Verlagsanstalt & Wipf & Stock Publishers. pp. 77-99.
    Excerpt: 1. Introduction This chapter provides insight into the diverse ethical debates on genetics and epigenetics. Much controversy surrounds debates about intervening into the germline genome of human embryos, with catchwords such as genome editing, designer baby, and CRISPR/Cas. The idea that it is possible to design a child according to one’s personal preferences is, however, a quite distorted view of what is actually possible with new gene technologies and gene therapies. These are much more limited than (...)
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  19. Winch on Following a Rule: A Wittgensteinian Critique of Oakeshott.Gene Callahan - 2012 - Collingwood and British Idealism Studies 18 (2):167-175.
    Peter Winch famously critiqued Michael Oakeshott's view of human conduct. He argued that Oakeshott had missed the fact that truly human conduct is conduct that 'follows a rule.' This paper argues that, as is sometimes the case with Oakeshott, what seems, on the surface, to be a disagreement with another, somewhat compatible thinker about a matter of detail in some social theory in fact turns out to point to a deeper philosophical divide. In particular, I contend, Winch, as typical of (...)
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  20. Ion.Gene Fendt - 1997 - International Studies in Philosophy 29 (4):23-50.
    This reading of Plato's Ion shows that the philosophic action mimed and engendered by the dialogue thoroughly reverses its (and Plato's) often supposed philosophical point, revealing that poetry is just as defensible as philosophy, and only in the same way. It is by Plato's indirections we find true directions out: the war between philosophy and poetry is a hoax on Plato's part, and a mistake on the part of his literalist readers. The dilemma around which the dialogue moves is false, (...)
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  21. Full and partial grounding.Kelly Trogdon & D. Gene Witmer - 2021 - Journal of the American Philosophical Association 7 (2):252-271.
    Discussion of partial grounds that aren't parts of full grounds; definition of full grounding in terms of partial grounding.
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  22. Camus and Aristotle on the Art Community and its Errors.Gene Fendt - 2021 - Labyrinth: An International Journal for Philosophy, Value Theory and Sociocultural Hermeneutics 22 (2):40.
    The purpose of this paper is to show the agreement of Camus and Aristotle on the cultural function of the art community, in particular their criticism of what should be called barbarian or nihilistic practices of art. Camus' art and criticism have been frequent targets of modern critics, but his point is and would be that such critics have the wrong idea of the purpose of art. His answer to such critics and the parallelism of his ideas with Aristotle's criticism (...)
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  23. How to play the Platonic flute: Mimêsis and Truth in Republic X.Gene Fendt - 2018 - In Heather L. Reid & Jeremy C. DeLong (eds.), The Many Faces of Mimēsis: Selected Essays from the Third Interdisciplinary Symposium on the Heritage of Western Greece,. Sioux City, IA, USA: Parnassos Press. pp. 37-48.
    The usual interpretation of Republic 10 takes it as Socrates’ multilevel philosophical demonstration of the untruth and dangerousness of mimesis and its required excision from a well ordered polity. Such readings miss the play of the Platonic mimesis which has within it precisely ordered antistrophes which turn its oft remarked strophes perfectly around. First, this argument, famously concluding to the unreliability of image-makers for producing knowledge begins with two images—the mirror (596e) and the painter. I will show both undercut the (...)
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  24. The Writ against Religious Drama: Frater Taciturnus v. Søren Kierkegaard.Gene Fendt - 1997 - In Niels J. Cappelørn (ed.), Kierkegaard Revisited: Proceedings From the Conference. Berlin, Germany: de Gruyter. pp. 48-74.
    In a very literarily complicated setting, Frater Taciturnus sets a remark about Hamlet not being a Christian tragedy. After unpeeling that literary setting and noting that Taciturnus' remark aims more at Jacob Börne than at Shakespeare, the paper shows how Frater Taciturnus' remark calls into question the religious project of a certain danish author. For, Taciturnus' primary concern is to show that religious drama is not possible, or at least "ought not be." This general law applies to Hamlet as well, (...)
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  25. Addiction: An Emergent Consequence of Elementary Choice Principles.Gene M. Heyman - 2013 - Inquiry: An Interdisciplinary Journal of Philosophy 56 (5):428 - 445.
    ABSTRACT Clinicians, researchers and the informed public have come to view addiction as a brain disease. However, in nature even extreme events often reflect normal processes, for instance the principles of plate tectonics explain earthquakes as well as the gradual changes in the face of the earth. In the same way, excessive drug use is predicted by general principles of choice. One of the implications of this result is that drugs do not turn addicts into compulsive drug users; they retain (...)
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  26.  94
    Pagan Politics, War, and the Construction of Nomoi.Gene Fendt - 1997 - In Plato's Political Philosophy, Vol. 2. pp. 58-71.
    The problem Plato sounds from the first lines of LAWS, his final dialogue, might be put in Jean-François Lyotard's term: it is the problem of the differend. Lyotard's position is briefly explained, shown to be applicable to the discussion in several ways (not the least of which is the three different gods appealed to as sources of the laws). We then see how Plato makes a chorus of the differend, resolving Lyotard's modern problem.
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  27. The Others In/Of Aristotle’s Poetics.Gene Fendt - 1997 - Journal of Philosophical Research 22:245-260.
    This paper aims at interpreting (primarily) the first six chapters of Aristotle’s Poetics in a way that dissolves many of the scholarly arguments conceming them. It shows that Aristotle frequently identifies the object of his inquiry by opposing it to what is other than it (in several different ways). As a result aporiai arise where there is only supposed to be illuminating exclusion of one sort or another. Two exemplary cases of this in chapters 1-6 are Aristotle’s account of mimesis (...)
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  28. Sublimity and Human Works: Kant on Tragedy and War.Gene Fendt - 1995 - Proceedings of the Eighth International Kant Congress 2:509-517.
    Kant admits that there are two kinds of human works that have something sublime about them, the work of the poet, e.g., tragedy, and the work of the politician, i.e., war. This paper will explore Kant's reasoning about the sublime element in these two human works.
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  29. Ideal Types and the Historical Method.Gene Callahan - 2007 - Collingwood and British Idealism Studies 13 (1):53-68.
    A number of social theorists have contended that the essence of historical analysis is the employment of ideal types to comprehend past goings-on. But, while acknowledging that the study of history through ideal types can yield genuine insight, we may still ask if it represents the full emancipation of historical understanding from other modes of conceiving the past. This paper follows Michael Oakeshott's work on the philosophy of history in arguing that explaining the historical past by means of ideal types, (...)
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  30. Comic Cure for Delusional Democracy: Plato's Republic.Gene Fendt - 2014 - Lanham, MD: Lexington Books.
    In this book, author Gene Fendt shows how Plato's Republic provides a liturgical purification for the political and psychic delusions of democratic readers, even as Socrates provides the same for his interlocutors at the festival of Bendis. Each of the several characters is analyzed in accord with Book Eight's 6 geometrically possible kinds of character showing how their answers and failures in the dialogue exhibit the particular kind of movement and blindness predictable for the type.
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  31. The Idea of a Social Cycle.Gene Callahan & Andreas Hoffman - manuscript
    The paper aims to explore what it means for something to be a social cycle, for a theory to be a social cycle theory, and to offer a suggestion for a simple, yet, we believe, fundamentally grounded schema for categorizing them. We show that a broad range of cycle theories can be described within the concept of disruption and adjustments. Further, many important cycle theories are true endogenous social cycle theories in which the theory provides a reason why the cycle (...)
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  32. Suicide by Democracy: An Obituary for America and the World 2nd Edition.Michael Starks - 2019 - Las Vegas, USA: Reality Press.
    Among the millions of pages of print and web pages and incessant chat and chatter on TV and blogs and speeches, there is a notable absence of a short clear honest, accurate, sane, intelligent summary of the catastrophe that is destroying America and the world. This is partly due to a lack of understanding and partly to the suppression of free speech by the leftist/liberal/progressive/democratic/socialist/multicultural/diverse/social democratic/communist/third world supremacist coalition. I attempt to fill that gap here. -/- An integral part of (...)
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  33. Suicidal Utopian Delusions in the 21st Century: Philosophy, Human Nature and the Collapse of Civilization-- Articles and Reviews 2006-2017 2nd Edition Feb 2018.Michael Starks - 2016 - Las Vegas, USA: Reality Press.
    This collection of articles was written over the last 10 years and edited to bring them up to date (2019). All the articles are about human behavior (as are all articles by anyone about anything), and so about the limitations of having a recent monkey ancestry (8 million years or much less depending on viewpoint) and manifest words and deeds within the framework of our innate psychology as presented in the table of intentionality. As famous evolutionist Richard Leakey says, it (...)
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  34. Intrinsicality without naturalness.D. Gene Witmer, William Butchard & Kelly Trogdon - 2005 - Philosophy and Phenomenological Research 70 (2):326–350.
    Defense of an account of intrinsic properties in terms of (what is now called) grounding rather than naturalness.
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  35. Genetically Modifying Livestock for Improved Welfare: A Path Forward.Adam Shriver & Emilie McConnachie - 2018 - Journal of Agricultural and Environmental Ethics 31 (2):161-180.
    In recent years, humans’ ability to selectively modify genes has increased dramatically as a result of the development of new, more efficient, and easier genetic modification technology. In this paper, we argue in favor of using this technology to improve the welfare of agricultural animals. We first argue that using animals genetically modified for improved welfare is preferable to the current status quo. Nevertheless, the strongest argument against pursuing gene editing for welfare is that there are alternative approaches (...)
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  36. What is the sufficientarian precautionary principle?G. Owen Schaefer - 2019 - Bioethics 33 (9):1083-1084.
    In their recent article, Koplin, Gyngell and Savulescu (2019) assess the viability of the precautionary principle as a decision-making tool to determine whether and under what circumstances germline gene editing should proceed. While their survey of different forms of the precautionary principle is illuminating, the most novel contribution is a new account of the precautionary principle, what they dub the Sufficientarian Precautionary Principle (SPP). SPP is meant to avoid several problems with existing accounts, while comporting with at least (...)
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  37. Commentary: Setting the Bar Higher.Nicolas Delon - 2019 - Cambridge Quarterly of Healthcare Ethics 28 (1):40-45.
    Commentary on Neuhaus and Parent, 'Gene doping--In Animals?' (2019).
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  38. When Extinction Is Warranted: Invasive Species, Suppression-Drives and the Worst-Case Scenario.Ann C. Thresher - 2022 - Ethics, Policy and Environment 25 (2):132-152.
    Most current techniques to deal with invasive species are ineffective or have highly damaging side effects. To this end suppression-drives based on clustered regularly inter-spaced short palindromic repeats (CRISPR/Cas9) have been touted as a potential silver bullet for the problem, allowing for a highly focused, humane and cost-effective means of removing a target species from an environment. Suppression-drives come with serious risks, however, such that the precautionary principle seems to warrant us not deploying this technology. The focus of this paper (...)
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  39. An Identity Crisis in Philosophy.Samuel Kahn - forthcoming - Argumenta.
    The following seems to be a truism in modern day philosophy: No agent can have had other parents (IDENTITY). IDENTITY shows up in discussions of moral luck, parenting, gene editing, and population ethics. In this paper, I challenge IDENTITY. I do so by showing that the most plausible arguments that can be made in favor of IDENTITY do not withstand critical scrutiny. The paper is divided into four sections. In the first, I document the prevalence of IDENTITY. In (...)
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  40. Humanitarian Assistance for Wild Animals.Kyle Johannsen - 2021 - The Philosophers' Magazine 93:33-37.
    I argue that most wild animals live bad lives, and that we should intervene in nature to improve their wellbeing.
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  41. Wild Animal Ethics: The Moral and Political Problem of Wild Animal Suffering.Kyle Johannsen - 2021 - New York, NY, USA: Routledge.
    Though many ethicists have the intuition that we should leave nature alone, Kyle Johannsen argues that we have a duty to research safe ways of providing large-scale assistance to wild animals. Using concepts from moral and political philosophy to analyze the issue of wild animal suffering (WAS), Johannsen explores how a collective, institutional obligation to assist wild animals should be understood. He claims that with enough research, genetic editing may one day give us the power to safely intervene without (...)
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  42. CRISPR as a Driving Force: The Model T of Biotechnology.Carlos Mariscal & Angel Petropanagos - 2016 - Monash Bioethics Review 34 (2):1-16.
    The CRISPR system for gene editing can break, repair, and replace targeted sections of DNA. Although CRISPR gene editing has important therapeutic potential, it raises several ethical concerns. Some bioethicists worry CRISPR is a prelude to a dystopian future, while others maintain it should not be feared because it is analogous to past biotechnologies. In the scientific literature, CRISPR is often discussed as a revolutionary technology. In this paper we unpack the framing of CRISPR as a (...)
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  43. Creating Future People: The Science and Ethics of Genetic Enhancement (2nd edition).Jonathan Anomaly - 2024 - London, UK: Routledge.
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  44. Animal Rights and the Problem of r-Strategists.Kyle Johannsen - 2017 - Ethical Theory and Moral Practice 20 (2):333-45.
    Wild animal reproduction poses an important moral problem for animal rights theorists. Many wild animals give birth to large numbers of uncared-for offspring, and thus child mortality rates are far higher in nature than they are among human beings. In light of this reproductive strategy – traditionally referred to as the ‘r-strategy’ – does concern for the interests of wild animals require us to intervene in nature? In this paper, I argue that animal rights theorists should embrace fallibility-constrained interventionism: the (...)
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  45.  89
    Political Bioethics.Benjamin Gregg - 2022 - Journal of Medicine and Philosophy 47 (4):516-529.
    If bioethical questions cannot be resolved in a widely acceptable manner by rational argument, and if they can be regulated only on the basis of political decision-making, then bioethics belongs to the political sphere. The particular kind of politics practiced in any given society matters greatly: it will determine the kind of bioethical regulation, legislation, and public policy generated there. I propose approaching bioethical questions politically in terms of decisions that cannot be “correct” but that can be “procedurally legitimate.” Two (...)
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  46. Three Challenges for the Cosmopolitan Governance of Technoscience.Matthew Sample - manuscript
    Promising new solutions or risking unprecedented harms, science and its technological affordances are increasingly portrayed as matters of global concern, requiring in-kind responses. In a wide range of recent discourses and global initiatives, from the International Summits on Human Gene Editing to the Intergovernmental Panel on Climate Change, experts and policymakers routinely invoke cosmopolitan aims. The common rhetoric of a shared human future or of one humanity, however, does not always correspond to practice. Global inequality and a lack (...)
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  47. Eugenic Thinking.Robert A. Wilson - 2018 - Philosophy, Theory, and Practice in Biology 10.
    Projects of human improvement take both individual and intergenerational forms. The biosciences provide many technologies, including prenatal screening and the latest gene editing techniques, such as CRISPR, that have been viewed as providing the means to human improvement across generations. But who is fit to furnish the next generation? Historically, eugenics epitomizes the science-based attempt to improve human society through distinguishing kinds of people and then implementing social policies—from immigration restriction to sexual sterilization and euthanasia—that influence and even (...)
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  48. On the Possibility of Constructive Neutral Evolution.Arlin Stoltzfus - 1999 - Journal of Molecular Evolution 49 (2):169-181.
    The neutral theory often is presented as a theory of "noise" or silent changes at an isolated "molecular level", relevant to marking the steady pace of divergence, but not to the origin of biological structure, function, or complexity. Nevertheless, precisely these issues can be addressed in neutral models, such as those elaborated here in regard to scrambled ciliate genes, gRNA-mediated RNA editing, the transition from self-splicing to spliceosomal splicing, and the retention of duplicate genes. All of these are instances (...)
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  49. Habermas and the Question of Bioethics.Hille Haker - 2019 - European Journal for Philosophy of Religion 11 (4):61-86.
    In The Future of Human Nature, Jürgen Habermas raises the question of whether the embryonic genetic diagnosis and genetic modification threatens the foundations of the species ethics that underlies current understandings of morality. While morality, in the normative sense, is based on moral interactions enabling communicative action, justification, and reciprocal respect, the reification involved in the new technologies may preclude individuals to uphold a sense of the undisposability of human life and the inviolability of human beings that is necessary for (...)
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  50. Toward Realism About Genetic Enhancement.G. Owen Schaefer - 2019 - American Journal of Bioethics 19 (7):28-30.
    Volume 19, Issue 7, July 2019, Page 28-30.
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