Results for 'messenger-RNA'

96 found
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  1. Alteration in Prolactin Messenger Ribonucleic Acid Level during the Rat Estrous Cycle: Effect of Naloxone.Sun Kyeong Yu - 1990 - Korean Journal of Zoology 33 (2):183-190.
    The present study examines the physiological alterations in prolactin (PRL) messenger ribonucleic acid (mRNA) and serum PRL levels during the rat estrous cycle and the effed of naloxone, an endogenous opioid peptide receptor antagonist, on PRL gene expression during the rat estrous cycle. Adult female rats exhibiting at least two consecutive 4-day estrous cycles were used in this study. A single injection of naloxone (2mg/kg b.w.) or saline was given sc 30 mm prior to decapitation. Animals were sacrificed at (...)
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  2. Function of aggregated reticulocyte ribosomes in protein synthesis.Alfred Gierer - 1963 - J. Mol. Biol 6:148-157.
    Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is (...)
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  3. Epigenetics, Evolution, and Us.W. Malcolm Byrnes - 2003 - The National Catholic Bioethics Quarterly 3 (3):489-500.
    This essay moves along broad lines from molecular biology to evolutionary biology and ecology to theology. Its objectives are to: 1) present some recent scientific findings in the emerging field of epigenetics that indicate that it is “the genome in context,” not genes per se, that are important in biological development and evolution; 2) show that this weakens the gene-centric neo-Darwinist explanation of evolution which, in fact, shares a certain preformationist orientation with intelligent design theory; 3) argue that the evidence (...)
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  4. Arthur M. Diamond, Jr., Openness to Creative Destruction Sustaining Innovative Dynamism. Oxford: Oxford UP, 2019. [REVIEW]Kelly Kate Evans - 2021 - Journal of Value Inquiry 57 (3):581-592.
    The Pfizer-BioNTech coronavirus vaccine is 90 percent effective in protecting against COVID-19. It would not have been possible without the tireless effort of Professor Katalin Karikó, a scientific innovator fitting the mold of dynamic inventor Arthur Diamond presents in his book, Openness to Creative Destruction Sustaining Innovative Dynamism. Not only did Professor Karikó persist in her beliefs in the therapeutic potential of synthetic messenger RNA over the course of four decades, but she did so despite the criticisms of other (...)
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  5. That is life: communicating RNA networks from viruses and cells in continuous interaction.Guenther Witzany - 2019 - Annals of the New York Academy of Sciences:1-16.
    All the conserved detailed results of evolution stored in DNA must be read, transcribed, and translated via an RNAmediated process. This is required for the development and growth of each individual cell. Thus, all known living organisms fundamentally depend on these RNA-mediated processes. In most cases, they are interconnected with other RNAs and their associated protein complexes and function in a strictly coordinated hierarchy of temporal and spatial steps (i.e., an RNA network). Clearly, all cellular life as we know it (...)
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  6. RNA’s Role in the Origins of Life: An Agentic ‘Manager’, or Recipient of ‘Off-loaded’ Constraints?John E. Stewart - 2021 - Biosemiotics 14 (3):643-650.
    In his Target Article, Terrence Deacon develops simple models that assist in understanding the role of RNA in the origins of life. However, his models fail to adequately represent an important evolutionary dynamic. Central to this dynamic is the selection that impinges on RNA molecules in the context of their association with proto-metabolisms. This selection shapes the role of RNA in the emergence of life. When this evolutionary dynamic is appropriately taken into account, it predicts a role for RNA that (...)
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  7. Representational Solution to the Messenger-Shooting Objection.Błażej Skrzypulec - forthcoming - Acta Analytica.
    Representational accounts of painful experiences, which characterize contents of pain in indicative terms, face a serious problem known as the Messenger-Shooting Objection. This problem arises from the fact that indicative representational accounts do not seem to be able to accommodate the observation that painful experiences rationalize actions aimed towards their own removal. I present a novel representational account of painful experiences which can solve the Messenger-Shooting Objection while still being an indicative representational theory. I argue that the proposed (...)
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  8. The Non-Coding RNA Ontology : a comprehensive resource for the unification of non-coding RNA biology.Huang Jingshan, Eilbeck Karen, Barry Smith, A. Blake Judith, Dou Dejing, Huang Weili, A. Natale Darren, Ruttenberg Alan, Huan Jun & T. Zimmermann Michael - 2016 - Journal of Biomedical Semantics 7 (1).
    In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...)
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  9. DNA Habitats and Their RNA Inhabitants.Guenther Witzany (ed.) - 2015
    Most molecular biological concepts derive from physical chemical assumptions about the genetic code that are basically more than 40 years old. Additionally, systems biology, another quantitative approach, investigates the sum of interrelations to obtain a more holistic picture of nucleotide sequence order. Recent empirical data on genetic code compositions and rearrangements by mobile genetic elements and non-coding RNAs, together with results of virus research and their role in evolution, does not really fit into these concepts and compel a re-examination. In (...)
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  10. The development of non-coding RNA ontology.Jingshan Huang, Karen Eilbeck, Barry Smith, Judith Blake, Deijing Dou, Weili Huang, Darren Natale, Alan Ruttenberg, Jun Huan, Michael Zimmermann, Guoqian Jiang, Yu Lin, Bin Wu, Harrison Strachan, Nisansa de Silva & Mohan Vamsi Kasukurthi - 2016 - International Journal of Data Mining and Bioinformatics 15 (3):214--232.
    Identification of non-coding RNAs (ncRNAs) has been significantly improved over the past decade. On the other hand, semantic annotation of ncRNA data is facing critical challenges due to the lack of a comprehensive ontology to serve as common data elements and data exchange standards in the field. We developed the Non-Coding RNA Ontology (NCRO) to handle this situation. By providing a formally defined ncRNA controlled vocabulary, the NCRO aims to fill a specific and highly needed niche in semantic annotation of (...)
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  11. A domain ontology for the non-coding RNA field.Jingshan Huang, Karen Eilbeck, Judith A. Blake, Dejing Dou, Darren A. Natale, Alan Ruttenberg, Barry Smith, Michael T. Zimmermann, Guoqian Jiang & Yu Lin - 2015 - In Huang Jingshan, Eilbeck Karen, Blake Judith A., Dou Dejing, Natale Darren A., Ruttenberg Alan, Smith Barry, Zimmermann Michael T., Jiang Guoqian & Lin Yu, IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM 2015). pp. 621-624.
    Identification of non-coding RNAs (ncRNAs) has been significantly enhanced due to the rapid advancement in sequencing technologies. On the other hand, semantic annotation of ncRNA data lag behind their identification, and there is a great need to effectively integrate discovery from relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a precisely defined ncRNA controlled vocabulary, which can fill a specific and highly needed niche in unification of ncRNA biology.
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  12. Editorial: Genome Invading RNA Networks.L. P. Villarreal & Guenther Witzany - 2018 - Frontiers in Microbiology 9:1-3.
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  13. The cosmic toolkit for all possible observations: Martin Harwit: Cosmic messengers: The limits of astronomy in an unruly universe. Cambridge: Cambridge University Press, 2021, 380 pp, $39.99 HB. [REVIEW]William L. Vanderburgh - 2021 - Metascience 31 (1):77-80.
    A review of Martin Harwit, Cosmic Messengers (2021).
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  14. The Secrets of Life - The Vital Roles of RNA Networks and Viruses.Luis Villarreal & Guenther Witzany - 2020 - In Nancy Kimberly Dess, A Multidisciplinary Aproach to Embodiment - Understanding Human Being. New York: Routledge. pp. 20-26.
    Viruses and related infectious genetic parasites are the most abundant biological agents on this planet. They invade all cellular organisms, are key agents in the generation of adaptive and innate immune systems, and drive nearly all regulatory processes within living cells.
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  15. Crick's Adaptor Hypothesis and the Discovery of Transfer RNA: Experiment Surpassing Theoretical Prediction.Michael Fry - 2022 - Philosophy, Theory, and Practice in Biology 14 (11):1-31.
    Historically, hypotheses failed in most cases to correctly forecast the workings of complex biological systems. Francis Crick’s adaptor hypothesis, however, stands out as an exceptional case of a confirmed abstract prediction. This hypothesis presciently anticipated the existence of RNA adaptors that function as bridges between amino acids and the chemically different nucleic acid template for proteins. Crick conjectured that the adaptors are enzymatically charged with cognate amino acids, they bind to complementary protein-coding nucleic acid, and their liberated amino acids are (...)
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  16. Two genetic codes: Repetitive syntax for active non-coding RNAs; non-repetitive syntax for the DNA archives.Witzany Guenther - 2017 - Communicative and Integrative Biology 10 (2):e1297352-1 - e1297352-12.
    Current knowledge of the RNA world indicates 2 different genetic codes being present throughout the living world. In contrast to non-coding RNAs that are built of repetitive nucleotide syntax, the sequences that serve as templates for proteins share—as main characteristics—a non-repetitive syntax. Whereas non-coding RNAs build groups that serve as regulatory tools in nearly all genetic processes, the coding sections represent the evolutionarily successful function of the genetic information storage medium. This indicates that the differences in their syntax structure are (...)
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  17. The DNA Habitat and its RNA Inhabitants.Luis Villarreal & Guenther Witzany - 2013 - Genomics Insights 6:1-12.
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  18. Epigenetics Integrates Development, Signaling, Context, RNA-Networks and Evolution.Witzany Guenther - 2024 - In Guenther Witzany, Epigenetics in Biological Communication. Cham: SpringerNature. pp. 2-16.
    The metamorphosis from larvae to adult butterflies has represented the “mystery” of life since the ancient Greeks. How could we explain the various steps of development from caterpillars to the most beautiful butterflies? A mystery preva lent in the twentieth century concerned the storage of the complete genetic informa tion of an organism in the DNA of its every cell. How and why do so many different cell types develop throughout the lives of organisms at the right time and place? (...)
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  19. (1 other version)Self-empowerment of life through RNA networks, cells and viruses. [REVIEW]Witzany Guenther - 2023 - F1000Research 12 (138):1-27.
    Our understanding of the key players in evolution and of the development of all organisms in all domains of life has been aided by current knowledge about RNA stem-loop groups, their proposed interaction motifs in an early RNA world and their regulative roles in all steps and substeps of nearly all cellular processes, such as replication, transcription, translation, repair, immunity and epigenetic marking. Cooperative evolution was enabled by promiscuous interactions between single-stranded regions in the loops of naturally forming stem-loop structures (...)
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  20. Evolution of Genetic Information without Error Replication.Guenther Witzany - 2020 - In Theoretical Information Studies. Singapur: pp. 295-319.
    Darwinian evolutionary theory has two key terms, variations and biological selection, which finally lead to survival of the fittest variant. With the rise of molecular genetics, variations were explained as results of error replications out of the genetic master templates. For more than half a century, it has been accepted that new genetic information is mostly derived from random error-based events. But the error replication narrative has problems explaining the sudden emergence of new species, new phenotypic traits, and genome innovations (...)
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  21. Modeling the Biologically Possible: Evolvability as a Modal Concept.Marcel Weber - 2025 - In Tarja Knuuttila, Till Grüne-Yanoff, Rami Koskinen & Ylwa Wirling, Modeling the Possible. Perspectives from Philosophy of Science. London: Routledge. pp. 121-140.
    Biological modalities, i.e., biologically possible, impossible, or necessary states of affairs have not received much attention from philosophers. Yet, it is widely agreed that there are biological constraints on physically possible states of affairs, such that not everything that is physically possible is also biologically possible, even if everything that is biologically possible is also physically possible. Furthermore, biologists use concepts that appear to be modal in nature, such as the concept of evolvability in evolutionary developmental biology, or “evo-devo.” The (...)
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  22. What is Life?Guenther Witzany - 2020 - Frontiers in Astronomy and Space Sciences 7:1-13.
    In searching for life in extraterrestrial space, it is essential to act based on an unequivocal definition of life. In the twentieth century, life was defined as cells that self-replicate, metabolize, and are open for mutations, without which genetic information would remain unchangeable, and evolution would be impossible. Current definitions of life derive from statistical mechanics, physics, and chemistry of the twentieth century in which life is considered to function machine like, ignoring a central role of communication. Recent observations show (...)
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  23. Structure and biological function of ribonucleic acid from Tobacco Mosaic Virus.Alfred Gierer - 1957 - Nature 179:1297-1299.
    Within the sedimentation diagram of infective RNA preparations isolated from Tobacco Mosaic Virus, undegraded molecules form a sharp peak with a molecular weight corresponding to the total RNA content of the virus particle. Degradation kinetics by ribonuclease is of the linear, single-target type, indicating that the RNA is single-stranded. The intact RNA of a virus particle thus forms one big single-stranded molecule. Quantitative evaluation of the effect degradation by RNA-ase on the infectivity of the RNA shows that the integrity of (...)
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  24. Production of mutants of Tobacco Mosaic Virus by chemical alteration of its nucleic acid in vitro.Alfred Gierer & K. W. Mundry - 1958 - Nature 182:1457-1458.
    The generation of viral mutants in vitro was demonstrated by treatment of the isolated RNA of Tobacco Mosaic Virus by nitrous acid. This agent causes deaminations converting cytosine into uracil, and adenine into hypoxanthine. Our assay for mutagenesis was the production of local lesions on a tobacco variety on which the untreated strain produces systemic infections only. A variety of different mutants are generated in this way. Quantitative analysis of the kinetics of mutagenesis leads to the conclusion that alteration of (...)
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  25. Quasispecies Productivity.Guenther Witzany - 2024 - The Science of Nature (Naturwissenschaften) 111:11.
    Abstract The quasispecies theory is a helpful concept in the explanation of RNA virus evolution and behaviour, with a relevant impact on methods used to fight viral diseases. It has undergone some adaptations to integrate new empirical data, especially the non-deterministic nature of mutagenesis, and the variety of behavioural motifs in cooperation, competition, communication, innovation, integration, and exaptation. Also, the consortial structure of quasispecies with complementary roles of memory genomes of minority populations better fits the empirical data than did the (...)
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  26. Artificial and Natural Genetic Information Processing.Guenther Witzany - 2017 - In Mark Burgin & Wolfgang Hoflkirchner, Information Studies and the Quest for Transdisciplinarity. New York, USA: World Scientific. pp. 523-547.
    Conventional methods of genetic engineering and more recent genome editing techniques focus on identifying genetic target sequences for manipulation. This is a result of historical concept of the gene which was also the main assumption of the ENCODE project designed to identify all functional elements in the human genome sequence. However, the theoretical core concept changed dramatically. The old concept of genetic sequences which can be assembled and manipulated like molecular bricks has problems in explaining the natural genome-editing competences of (...)
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  27. A semantic approach for knowledge capture of microRNA-target gene interactions.Jingshan Huang, Fernando Gutierrez, Dejing Dou, Judith A. Blake, Karen Eilbeck, Darren A. Natale, Barry Smith, Yu Lin, Xiaowei Wang & Zixing Liu - 2015 - In Jingshan Huang, Fernando Gutierrez, Dejing Dou, Judith A. Blake, Karen Eilbeck, Darren A. Natale, Barry Smith, Yu Lin, Xiaowei Wang & Zixing Liu, IEEE International Conference on Bioinformatics and Biomedicine (IEEE BIBM 2015),. pp. 975-982.
    Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In our (...)
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  28. OmniSearch: a semantic search system based on the Ontology for MIcroRNA Target Gene Interaction data.Huang Jingshan, Gutierrez Fernando, J. Strachan Harrison, Dou Dejing, Huang Weili, A. Blake Judith, Barry Smith, Eilbeck Karen, A. Natale Darren & Lin Yu - 2016 - Journal of Biomedical Semantics 7 (1):1.
    In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...)
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  29. On the Possibility of Constructive Neutral Evolution.Arlin Stoltzfus - 1999 - Journal of Molecular Evolution 49 (2):169-181.
    The neutral theory often is presented as a theory of "noise" or silent changes at an isolated "molecular level", relevant to marking the steady pace of divergence, but not to the origin of biological structure, function, or complexity. Nevertheless, precisely these issues can be addressed in neutral models, such as those elaborated here in regard to scrambled ciliate genes, gRNA-mediated RNA editing, the transition from self-splicing to spliceosomal splicing, and the retention of duplicate genes. All of these are instances of (...)
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  30.  98
    Quasispecies Productivity.Esteban Domingo & Guenther Witzany - 2024 - The Science of Nature 111 (11):11.
    The quasispecies theory is a helpful concept in the explanation of RNA virus evolution and behaviour, with a relevant impact on methods used to fight viral diseases. It has undergone some adaptations to integrate new empirical data, especially the non-deterministic nature of mutagenesis, and the variety of behavioural motifs in cooperation, competition, communication, innovation, integration, and exaptation. Also, the consortial structure of quasispecies with complementary roles of memory genomes of minority populations better fits the empirical data than did the original (...)
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  31. Crucial steps to life: From chemical reactions to code using agents.Witzany Guenther - 2016 - Biosystems 140:49-57.
    The concepts of the origin of the genetic code and the definitions of life changed dramatically after the RNA world hypothesis. Main narratives in molecular biology and genetics such as the “central dogma,” “one gene one protein” and “non-coding DNA is junk” were falsified meanwhile. RNA moved from the transition intermediate molecule into centre stage. Additionally the abundance of empirical data concerning nonrandom genetic change operators such as the variety of mobile genetic elements, persistent viruses and defectives do not fit (...)
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  32. The biocommunication method: On the road to an integrative biology.Witzany Guenther - 2016 - Communicative and Integrative Biology 9:e1164374.
    Although molecular biology, genetics, and related special disciplines represent a large amount of empirical data, a practical method for the evaluation and overview of current knowledge is far from being realized. The main concepts and narratives in these fields have remained nearly the same for decades and the more recent empirical data concerning the role of noncoding RNAs and persistent viruses and their defectives do not fit into this scenario. A more innovative approach such as applied biocommunication theory could translate (...)
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  33.  37
    A CODES-Based Approach to Cancer as a Coherence Disorder.Devin Bostick - manuscript
    Abstract -/- Cancer has traditionally been framed as a genetic mutation-driven disease, with instability at the molecular level leading to uncontrolled cellular proliferation. Yet this paradigm fails to account for several longstanding anomalies: genetically identical cells in the same environment may behave divergently; some tumors remain dormant for decades, while others regress without treatment. These contradictions suggest a deeper organizing principle is at play. -/- This paper introduces a new model grounded in the CODES framework (Chirality of Dynamic Emergent Systems), (...)
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  34. Две декады.Andrej Poleev - 2023
    Поводом для составления очередного сборника моих публикаций являются две знаменательные даты: первая из них — двадцатилетие основания моего журнала, покончившего с академическим абсолютизмом, и вторая — десятилетие Конституции общности Русь, отменившей политический деспотизм демократии. Всё остальное, написанное, сказанное, и показанное публике индустрией массового оглупления в этом году, произведено лишь с целью сокрытия истины. Поскольку это в принципе невозможно, то злоумышленникам остаётся только лгать, посредством чего производимый ими мусор они выдают за заслуживающую доверия и жизненно важную информацию, позиционируя себя в качестве (...)
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  35. Believing to Belong: Addressing the Novice-Expert Problem in Polarized Scientific Communication.Helen De Cruz - 2020 - Social Epistemology 34 (5):440-452.
    There is a large gap between the specialized knowledge of scientists and laypeople’s understanding of the sciences. The novice-expert problem arises when non-experts are confronted with (real or apparent) scientific disagreement, and when they don’t know whom to trust. Because they are not able to gauge the content of expert testimony, they rely on imperfect heuristics to evaluate the trustworthiness of scientists. This paper investigates why some bodies of scientific knowledge become polarized along political fault lines. Laypeople navigate conflicting epistemic (...)
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  36. Biochemical functions.Francesca Bellazzi - forthcoming - British Journal for the Philosophy of Science.
    Function talk is a constant across different life sciences. From macro-evolution to genetics, functions are mentioned everywhere. For example, a limb’s function is to allow movement and RNA polymerases’ function is to transcribe DNA. Biochemistry is not immune from such a characterization; the biochemical world seems to be a chemical world embedded within biological processes. Specifically, biochemists commonly ascribe functions to biomolecules and classify them accordingly. This has been noticed in the recent philosophical literature on biochemical kinds. But while a (...)
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  37. Christian Military Chaplains as Promoters of the Gospel of Non-Violence and Mutual Co-Existence in Contemporary Nigerian Society: An Ethical Study.Emmanuel Orok Duke - 2018 - Journal for Inculturation Theology 5 (1):258-271.
    Contemporary Nigerian society is in its doldrums as regards the culture of violence and distrust among peoples from various ethnic groups that make-up this nation. To an extent, religio-political reasons are fueling this culture of violence and distrust. The thrust of this paper is that: Christian military chaplains are stakeholders as promoters of peace and mutual co-existence in Nigeria with regard to controlling the culture of violence and disunity. The core of this thesis remains Jesus’ convictions concerning non-resistance to the (...)
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  38. The mismeasure of machine: Synthetic biology and the trouble with engineering metaphors.Maarten Boudry & Massimo Pigliucci - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (4):660-668.
    The scientific study of living organisms is permeated by machine and design metaphors. Genes are thought of as the ‘‘blueprint’’ of an organism, organisms are ‘‘reverse engineered’’ to discover their functionality, and living cells are compared to biochemical factories, complete with assembly lines, transport systems, messenger circuits, etc. Although the notion of design is indispensable to think about adaptations, and engineering analogies have considerable heuristic value (e.g., optimality assumptions), we argue they are limited in several important respects. In particular, (...)
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  39. On The Content and Character of Pain Experience.Richard Gray - 2019 - Pacific Philosophical Quarterly 100 (1):47-68.
    Tracking representationalism explains the negative affective character of pain, and its capacity to motivate action, by reference to the representation of the badness for us of bodily damage. I argue that there is a more fitting instantiation of the tracking relation – the badness for us of extremely intense stimuli – and use this to motivate a non-reductive approach to the negative affective character of pain. The view of pain proposed here is supported by consideration of three related topics: the (...)
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  40. The Quest for System-Theoretical Medicine in the COVID-19 Era.Felix Tretter, Olaf Wolkenhauer, Michael Meyer-Hermann, Johannes W. Dietrich, Sara Green, James Marcum & Wolfram Weckwerth - 2021 - Frontiers in Medicine 8:640974.
    Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...)
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  41. How Viruses Made Us Humans.Guenther Witzany - 2024 - In Nathalie Gontier, Andy Lock & Chris Sinha, The Oxford Handbook of Human Symbolic Evolution. OUP. pp. 1-20.
    Current research on the origin of DNA and RNA, viruses, and mobile genetic elements prompts a re-evaluation of the origin and nature of genetic material as the driving force behind evolutionary novelty. While scholars used to think that novel features resulted from random genetic mutations of an individual’s specific genome, today we recognize the important role that acquired viruses and mobile genetic elements have played in introducing evolutionary novelty within the genomes of species. Viral infections and subviral RNAs can enter (...)
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  42.  81
    A New Framework for Quantum-Classical Transitions: An Elastic Approach to Information Preservation.Robert Somazze - manuscript
    In the quest to understand our universe, we find ourselves armed with two powerful yet seemingly incompatible frameworks: quantum mechanics and classical physics. Light, serving as our universal messenger, bridges our observations from the smallest quantum scales to the largest cosmic structures. This paper proposes a conceptual framework for understanding quantum-classical transitions through the lens of elastic information preservation. -/- To illustrate these transitions across scales, consider a single photon in the quantum realm. From any given reference frame, its (...)
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  43. Complexity Reality and Scientific Realism.Avijit Lahiri - manuscript
    We introduce the notion of complexity, first at an intuitive level and then in relatively more concrete terms, explaining the various characteristic features of complex systems with examples. There exists a vast literature on complexity, and our exposition is intended to be an elementary introduction, meant for a broad audience. -/- Briefly, a complex system is one whose description involves a hierarchy of levels, where each level is made of a large number of components interacting among themselves. The time evolution (...)
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  44. Natural Genome Editing from a Biocommunicative Perspective.Guenther Witzany - 2011 - Biosemiotics 4 (3):349-368.
    Natural genome editing from a biocommunicative perspective is the competent agent-driven generation and integration of meaningful nucleotide sequences into pre-existing genomic content arrangements, and the ability to (re-)combine and (re-)regulate them according to context-dependent (i.e. adaptational) purposes of the host organism. Natural genome editing integrates both natural editing of genetic code and epigenetic marking that determines genetic reading patterns. As agents that edit genetic code and epigenetically mark genomic structures, viral and subviral agents have been suggested because they may be (...)
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  45. Rules of Tajweed the Holy Quran Intelligent Tutoring System.Alaa N. Akkila & Samy S. Abu-Naser - 2018 - International Journal of Academic Pedagogical Research (IJAPR) 2 (3):7-20.
    Undeniably, the greatest way for a Moslem to be closer to Allah, is recitation of Holy-Quran approves with the method conveyed from Messenger of Allah Mohammed from the feature of speech points of letters and the intrinsic and fleeting characteristics of the letters, So, there is a persistent need to teach all Moslems the science of Tajweed Al-Quran. ITS (Intelligent Tutoring System) is computer software that supplies direct and tailored training or response to students without human teacher interfering. The (...)
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  46. Temporal changes in ovarian gonadotropin-releasing hormone mRNA levels by gonadotropins in the rat.Sun Kyeong Yu - 1994 - Mol Cells 4:39-44.
    Temporal Changes in Ovarian Gonadotropin-Releasing Hormone mRNA Levels by Gonadotropins in the Rat Sung Ho Lee, Eun-Seob Song, Sun Kyeong Yu, Changmee Kim, Dae Kee Lee, Wan Sung Choi l and Kyungjin Kim* Department of Molecular Biofogy and SRC for Cell Differentiation, Seoul National University, Seoul 150-742, Korea; IDepartment of Anatomy, College of Medicine, Gyeongsanf; National University, Chinju 660-280, Korea (Recei·. cd on December 29, 1993) The present study examines whether gonadotropins are involved in the regulation of ovarian GnRH gene (...)
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  47. Angeletics and Epistemology, Angeletics as Epistemology: A Comparison Between Capurro’s Angeletics and Goldman’s Social Epistemology.Pak-Hang Wong - 2011 - In Rafael Capurro & John Holgate, Messages and Messengers – Angeletics as an Approach to the Phenomenology of Communication / Von Boten und Botschaften – Die Angeletik als Weg zur Phänomenologie der Kommunikation. Wilhelm Fink Verlag.
    Nearly a decade ago, Rafael Capurro has gradually shifted his attention towards the ideas of message and of messenger. In lieu of ‘information’, he proposes and develops a new direction of research he calls Angeletics that aims to examine the nature of message and messenger, both of which are inherently social. Coincidently, at about the same time, we witnessed the rise of social epistemology in Angelo-American analytic philosophy. This coincidence is interesting, because both Capurro’s Angeletics and social epistemology (...)
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  48. The Paradox of the Question.Ned Markosian - 1997 - Analysis 57 (2):95-97.
    Once upon a time, during a large and international conference of the world's leading philosophers, an angel miraculously appeared and said, "I come to you as a messenger from God. You will be permitted to ask any one question you want - but only one! - and I will answer that question truthfully. What would you like to ask?" The philosophers were understandably excited, and immediately began a discussion of what would be the best question to ask. But it (...)
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  49. The Plant Ontology as a Tool for Comparative Plant Anatomy and Genomic Analyses.Laurel Cooper, Ramona Walls, Justin Elser, Maria A. Gandolfo, Dennis W. Stevenson, Barry Smith & Others - 2013 - Plant and Cell Physiology 54 (2):1-23..
    The Plant Ontology (PO; http://www.plantontology.org/) is a publicly-available, collaborative effort to develop and maintain a controlled, structured vocabulary (“ontology”) of terms to describe plant anatomy, morphology and the stages of plant development. The goals of the PO are to link (annotate) gene expression and phenotype data to plant structures and stages of plant development, using the data model adopted by the Gene Ontology. From its original design covering only rice, maize and Arabidopsis, the scope of the PO has been expanded (...)
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  50. To the End of Dogmatism in Molecular Biology.Guenther Witzany - 2021 - Biosemiotics 14 (1):67-72.
    Denis Nobel looks at four important misinterpretations of molecular biology concerning evolutionary processes and demonstrates that the new synthesis today looks rather outdated. The modern synthesis is nearly 80 years old. The proponents who worked out the modern synthesis had no access to the current knowledge on cell biology, genetics, epigenetics, RNA biology and virology. Therefore this contribution adds several aspects which Nobel’s article does not explicitly mention, providing some examples for a better understanding of evolutionary novelty.
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