Unless one embraces activities as foundational, understanding activities in mechanisms requires an account of the means by which entities in biological mechanisms engage in their activities—an account that does not merely explain activities in terms of more basic entities and activities. Recent biological research on molecular motors exemplifies such an account, one that explains activities in terms of free energy and constraints. After describing the characteristic “stepping” activities of these molecules and mapping the stages of those steps onto the (...) stages of the motors’ hydrolytic cycles, researchers pieced together from images of the molecules in different hydrolyzation states accounts of how the chemical energy in ATP is transformed in the constrained environments of the motors into the characteristic activities of the motors. We argue that New Mechanism’s standard set of analytic categories—entities, activities, and organization—should be expanded to include constraints and energetics. Not only is such an expansion required descriptively to capture research on molecular motors but, more importantly from a philosophical point of view, it enables a non-regressive account of activities in mechanisms. In other words, this expansion enables a philosophical account of mechanistic explanation that avoids a regress of entities and activities “all the way down.” Rather, mechanistic explanation bottoms out in constraints and energetics. (shrink)

This chapter focuses on the experimental practices and reasoning strategies employed in nineteenth century investigations on the causal origin of the phenomenon of Brownian movement. It argues that there was an extensive and sophisticated experimental work done on the phenomenon throughout the nineteenth century. Investigators followed as rigorously as possible the methodological standards of their time to make causal claims and advance causal explanations of Brownian movement. Two major methodological strategies were employed. The first was the experimental strategy of varying (...) the circumstances. Suspected causal factors were varied and the resulting effect on Brownian movement was studied. The main goal of this strategy was the identification of difference-making factors, i.e., factors having a causal influence on the phenomenon. The second was the so-called method of hypothesis. Rather than relying exclusively on the ability of experiments to identify difference-making factors, its proponents tried to show how the independently developed tenets of the new kinetic-molecular conception of matter provided a plausible causal explanation of Brownian movement. Each one of these methodological strategies had its distinctive practices and notions of control. None of these strategies could, on its own, establish molecular motion as the cause of Brownian movement. It was only the fruitful combination of the two strategies and of their accompanying practices and notions of control that led, at the end of the nineteenth century, to the recognition of molecular motion as the most probable cause of Brownian movement. (shrink)

In 1926, Haldane published an essay titled 'On Being the Right Size' in which he argued that the structure, function, and behavior of an organism are strongly conditioned by the physical forces that exert the greatest impact at the scale at which it exists. This chapter puts Haldane’s insight to work in the context of contemporary cell and molecular biology. Owing to their minuscule size, cells and molecules are subject to very different forces than macroscopic organisms. In a sense, (...) macroscopic and microscopic entities inhabit different “worlds”: the former is ruled by gravity and inertia, whereas the latter is governed by Brownian motion. One implication is that we should be extremely skeptical of models and analogies that seek to explain properties of microscopic entities by appealing to properties of macroscopic ones. Unfortunately, this is precisely what the appeal to engineering metaphors in molecular biology attempts to do. Molecular biologists routinely resort to such metaphors because they are familiar and intuitively intelligible. But if our machines were the size of molecules it would be impossible for them to function the way they do. It follows that we should avoid distorting biological reality by construing it in engineering terms. In this chapter I examine four key metaphors in molecular biology – “genetic program,” “cellular circuitry,” “molecular machine,” and “molecular motor” – and I argue that their deficiencies derive from their neglect of scale. I also try to explain why many biologists today appear to have forgotten the importance of scale that Haldane drew attention to in his essay. I suggest that the reason has to do with the influence of Schrödinger’s argument in 'What is Life?' regarding the stability of the gene. (shrink)

In this paper it is argued that the multiple realizability argument and Kripke's argument are based on schemas of identifications rather than identification. In fact, "heat = molecular motion" includes a term "molecular motion" that does not capture a natural kind, nor has a unique referent. If properly framed, this schema suits also for the type identity theory of mind. Some consequences of this point are evaluated.

The theme of phenomenology and quantum physics is here tackled by examining some basic interpretational issues in quantum physics. One key issue in quantum theory from the very beginning has been whether it is possible to provide a quantum ontology of particles in motion in the same way as in classical physics, or whether we are restricted to stay within a more limited view of quantum systems, in terms of complementary but mutually exclusive phenomena. In phenomenological terms we could (...) describe the situation by saying that according to the usual interpretation of quantum theory, quantum phenomena require a kind of epoche. However, there are other interpretations that seem to re-establish the possibility of a mind-independent ontology at the quantum level. We will show that even such ontological interpretations contain novel, non-classical features, which require them to give a special role to “phenomena” or “appearances”, a role not encountered in classical physics. We will conclude that while ontological interpretations of quantum theory are possible, quantum theory implies the need of a certain kind of epoche even for this type of interpretations. While different from the epoche connected to phenomenological description, the “quantum epoche” nevertheless points to a potentially interesting parallel between phenomenology and quantum philosophy. (shrink)

There is consensus within the chemosciences that olfactory perception is of the molecular structure of chemical compounds, yet within philosophical theories of smell there is little agreement about the nature of smell. The paper critically assesses the current state of debate regarding smells within philosophy in the hopes of setting it upon firm scientific footing. The theories to be covered are: Naïve Realism, Hedonic Theories, Process Theory, Odor Theories, and non-Objectivist Theories. The aforementioned theories will be evaluated based on (...) their explanations of the (a) the olfactory quality of a smell, (b) smells as distal entities, and (c) our experience of smells as intentional objects. The paper concludes with a defense of Molecular Structure Theory that demonstrating its superiority in accounting for each of these three aspects of smell. (shrink)

This work takes into account three Cartesian manuals diffused in 17th century France ; Jacques Rohault, Traité de physique ; Pierre-Sylvain Régis, Cours entier de philosophie, ou système general selon les principes de M. Descartes contenant la logique, la metaphysique, la physique et la morale ) in order to question if the development of an empirical attitude in the scientific research influenced their approaches to the study of motion. The article intends to deepen the role that these authors give (...) to God in the physical structure of the universe with the purpose of investigating whether their analysis of motion is untainted by the metaphysical component or on what terms it remains linked to it. (shrink)

I argue that Plato believes that the soul must be both the principle of motion and the subject of cognition because it moves things specifically by means of its thoughts. I begin by arguing that the soul moves things by means of such acts as examination and deliberation, and that this view is developed in response to Anaxagoras. I then argue that every kind of soul enjoys a kind of cognition, with even plant souls having a form of Aristotelian (...) discrimination (krisis), and that there is therefore no completely unintelligent, evil soul in the cosmos that can explain disorderly motions; as a result, the soul is not the principle of all motion but only motion in the cosmos after it has been ordered by the Demiurge. (shrink)

In apparent motion experiments, participants are presented with what is in fact a succession of two brief stationary stimuli at two different locations, but they report an impression of movement. Philosophers have recently debated whether apparent motion provides evidence in favour of a particular account of the nature of temporal experience. I argue that the existing discussion in this area is premised on a mistaken view of the phenomenology of apparent motion and, as a result, the space (...) of possible philosophical positions has not yet been fully explored. In particular, I argue that the existence of apparent motion is compatible with an account of the nature of temporal experience that involves a version of direct realism. In doing so, I also argue against two other claims often made about apparent motion, viz. that apparent motion is the psychological phenomenon that underlies motion experience in the cinema, and that apparent motion is subjectively indistinguishable from real motion. (shrink)

Whether or not quantum physics can account for molecular structure is a matter of considerable controversy. Three of the problems raised in this regard are the problems of molecular structure. We argue that these problems are just special cases of the measurement problem of quantum mechanics: insofar as the measurement problem is solved, the problems of molecular structure are resolved as well. In addition, we explore one consequence of our argument: that claims about the reduction or emergence (...) of molecular structure cannot be settled independently of the choice of a particular resolution to the measurement problem. Specifically, we consider how three standard putative solutions to the measurement problem inform our under- standing of a molecule in isolation, as well as of chemistry’s relation to quantum physics. (shrink)

The concept of Substantial motion (حركت جوهرى) is fundamentally flawed and severely muddled. Aristotle and Mulla Sadra’s conception of motion, substance (جوهر) and substantial form صورت نوعيه)) were all based on a severe misunderstanding of nature as later was established by the scientists and philosophers that came after them. Here, by recalling the established facts of modern science, particularly the universally accepted scientific fact that, properties of objects are reducible to the motion of their electrons and there’s (...) no such thing as ‘substantial form’ much less substance, the author puts an end to a 400-year-old glorious error called ‘substantial motion’. Naturally any attempt to reconcile the paradigms of modern physics with Aristotle/Sadra paradigms of form/matter and substance/accidents, and to try to draw parallel between the two and revive their philosophy would be an exercise in futility. (shrink)

Without directly addressing the Demarcation Problem for logic—the problem of distinguishing logical vocabulary from others—we focus on distinctive aspects of logical vocabulary in pursuit of a second goal in the philosophy of logic, namely, proposing criteria for the justification of logical rules. Our preferred approach has three components. Two of these are effectively Belnap’s, but with a twist. We agree with Belnap’s response to Prior’s challenge to inferentialist characterisations of the meanings of logical constants. Belnap argued that for a logical (...) constant to exist, its rules must be conservative over a previously given consequence relation and guarantee the uniqueness of the constant. The twist is that we require logical vocabulary to be provably conservative, not over a previously given formal consequence relation, but over a previously given meaningful vocabulary of a language. Uniqueness is also a feature defined in terms of provability: if two syntactically distinguished expressions are governed by the same rules, then formulas with them as main operators are interderivable. Belnap’s criteria are not only those for the existence of a logical constant, but more: they are what distinguishes logical vocabulary from all other expressions. It is the defining mark of a logical constant that it is provably conservative over the fragment of the language which excludes it and that its rules guarantee its uniqueness. The third component is the topic neutrality of logic. The provable conservativeness of logic over a previously given vocabulary of a language is motivated, in part, by appeal to molecularism in the theory of meaning. Molecularity is a feature endorsed by the theory of meaning as a whole, so it does not distinguish logical constants from other expressions. The same is true for conservativeness. We argue that molecularity, and hence conservativeness, are implicit presuppositions of speakers’ use of language: the addition of new vocabulary to a language is presupposed to be conservative. But this presupposition is one that we should be able reflectively to endorse (such as when attempting a rational reconstruction of the use of the vocabulary). Thus, where conservativeness is found to fail, this defect should be remedied and the use of the vocabulary corrected (as in classical negation) or excised altogether (as in pejoratives). We go on to characterise a notion of topic neutrality, which we argue applies to logical vocabulary. We then note that reflective endorsement of the conservativeness of a topic neutral vocabulary requires a proof that the vocabulary is conservative relative to any base vocabulary. Thus we require that logical vocabulary be demonstrably conservative. Allying this requirement, distinctive of logic, to a general consideration about the commitments of assertion yields a mode of justification for logical constants akin to some conceptions of Harmony, i.e., to the idea that the consequences of assertion of a logical complex need to be warranted by the grounds and ought to be the strongest consequences warranted by the grounds. Intuitionistic logic acquires a somewhat familiar justification but emanating from a new motivation. (shrink)

The paper argues that Motion and Rest are “greatest kinds” and not just convenient examples, since they are all-pervading. Thus Motion and Rest can be jointly predicated of a single subject and can be predicated of each other, just as Sameness and Otherness can. While Sameness and Otherness are opposites, a single subject may be the same in one respect, namely, the same as itself, and other in another respect, namely, other than other things. Thus they can be (...) predicated of a single subject, and they can be predicated of each other, as well, since Sameness is other than other things and Otherness is the same as itself. The same explanation applies to Motion and Rest, as the paper demonstrates: a given subject may be in motion in one respect while being at rest in another respect. This distinction is made in the Sophist itself, right in the passage concerning the greatest kinds. Thus Motion and Rest should be considered greatest kinds on par with Being, Sameness, and Otherness, and each of these kinds pervades all other kinds. (shrink)

This essay considers how scholarly approaches to the development of molecular biology have too often narrowed the historical aperture to genes, overlooking the ways in which other objects and processes contributed to the molecularization of life. From structural and dynamic studies of biomolecules to cellular membranes and organelles to metabolism and nutrition, new work by historians, philosophers, and STS scholars of the life sciences has revitalized older issues, such as the relationship of life to matter, or of physicochemical inquiries (...) to biology. This scholarship points to a novel molecular vista that opens up a pluralist view of molecularizations in the twentieth century and considers their relevance to current science. (shrink)

One of the most plausible and widely discussed examples of strong emergence is molecular structure. The only detailed account of it, which has been very influential, is due to Robin Hendry and is formulated in terms of downward causation. This paper explains Hendry’s account of the strong emergence of molecular structure and argues that it is coherent only if one assumes a diachronic reflexive notion of downward causation. However, in the context of this notion of downward causation, the (...) strong emergence of molecular structure faces three challenges that have not been met and which have so far remained unnoticed. First, the putative empirical evidence presented for the strong emergence of molecular structure equally undermines supervenience, which is one of the main tenets of strong emergence. Secondly, it is ambiguous how the assumption of determinate nuclear positions is invoked for the support of strong emergence, as the role of this assumption in Hendry’s argument can be interpreted in more than one way. Lastly, there are understandings of causation which render the postulation of a downward causal relation between a molecule’s structure and its quantum mechanical entities, untenable. (shrink)

In the texts of the middle years (roughly, the 1680s and 90s), Leibniz appears to endorse two incompatible approaches to motion, one a realist approach, the other a phenomenalist approach. I argue that once we attend to certain nuances in his account we can see that in fact he has only one, coherent approach to motion during this period. I conclude by considering whether the view of motion I want to impute to Leibniz during his middle years (...) ranks as a kind of realism or rather as some kind of phenomenalism or idealism. (shrink)

This essay proposes a new interpretation of a central, and yet overlooked, argument Leibniz offers against Descartes’s power-free ontology of the corporeal world. Appealing to considerations about the successiveness of motion, Leibniz attempts to show that the reality of motion requires force. It is often assumed that the argument is driven by concerns inspired by Zeno. Against such a reading, this essay contends that Leibniz’s argument is instead best understood against the background of an Aristotelian view of the (...) priority of real being over time. The essay also shows how this alternative interpretation can help to shed new light on the difference between Leibnizian forces and Aristotelian powers, as well as on Leibniz’s famous claim that accounting for force leads us beyond the mechanistic corporeal realm. (shrink)

The impetus theory of motion states that to be in motion is to have a non-zero velocity. The at-at theory of motion states that to be in motion is to be at different places at different times, which in classical physics is naturally understood as the reduction of velocities to position developments. I first defend the at-at theory against the criticism raised by Arntzenius that it renders determinism impossible. I then develop a novel impetus theory of (...) motion that reduces positions to velocity developments. As this impetus theory of motion is by construction a mirror image of the at-at theory of motion, I claim that the two theories of motion are in fact epistemically on par—despite the unfamiliar metaphysical picture of the world furnished by the impetus version. (shrink)

In the Metaphysical Foundations of Natural Science, Kant presents an argument for the centrality of <motion> to our concept <matter>. This argument has long been considered either irredeemably obscure or otherwise defective. In this paper I provide an interpretation which defends the argument’s validity and clarifies the sense in which it aims to show that <motion> is fundamental to our conception of matter.

Jacques Monod (1971) argued that certain molecular processes rely critically on the property of chemical arbitrariness, which he claimed allows those processes to “transcend the laws of chemistry”. It seems natural, as some philosophers have done, to interpret this in modal terms: a biological relationship is chemically arbitrary if it is possible, within the constraints of chemical “law”, for that relationship to have been otherwise than it is. But while modality is certainly important for understanding chemical arbitrariness, understanding its (...) biological role also requires an account of the concrete causal-functional features that distinguish arbitrary from non-arbitrary phenomena. In this paper I elaborate on this under-emphasised aspect by offering a general account of these features: arbitrary relations are instantiated by mechanisms that involve molecular adapters, which causally couple two properties or processes which would otherwise be uncorrelated. Additionally, adapters work by acting as intermediate rather than cooperating causes. (shrink)

Today, the lipid bilayer structure is nearly ubiquitous, taken for granted in even the most rudimentary introductions to cell biology. Yet the image of the lipid bilayer, built out of lipids with heads and tails, went from having obscure origins deep in colloid chemical theory in 1924 to being “obvious to any competent physical chemist” by 1935. This chapter examines how this schematic, strictly heuristic explanation of the idea of molecular orientation was developed within colloid physical chemistry, and how (...) the image was transformed into a reflection of the reality and agency of lipid molecules in the biological microworld. Whereas in physical and colloid chemistry these images considered secondary to instrumental measurement and mathematical modeling of surface phenomena, in biology the manipulable image of the lipid on paper became an essential tool for the molecularization of the cell. (shrink)

This item is a chapter from a book in progress, entitled "True Motion". Leibniz’s mechanics was, as we shall see, a theory of elastic collisions, not formulated like Huygens’ in terms of rules explicitly covering every possible combination of relative masses and velocities, but in terms of three conservation principles, including (effectively) the conservation of momentum and kinetic energy. That is, he proposed what we now call (ironically enough) ‘Newtonian’ (or ‘classical’) elastic collision theory. While such a theory is, (...) for instance, vital to the foundations of the kinetic theory of gases, it is not applicable to systems – like gravitational systems – in which fields of force are present. Thus, Leibniz’s mechanical principles never led to developments of the order of Newton’s in the Principia (additionally, he hamstrung their application by embedding them in a baroque philosophical system). (shrink)

In this paper I propose to describe, in brief, a semiotic paradigm which results from the redefinition of the linguistic sign as a molecular sememe. Borrowing a tactic from Wittgenstein, I wish to use the game of chess as an analogy for the sake of describing what a molecular sememe is. Then I hope to use it further to sketch several implications of this semiotic paradigm for literary criticism and critical theory.

Statements about the behavior of biochemical entities (e.g., about the interaction between two proteins) abound in the literature on molecular biology and are increasingly becoming the targets of information extraction and text mining techniques. We show that an accurate analysis of the semantics of such statements reveals a number of ambiguities that have to be taken into account in the practice of biomedical ontology engineering: Such statements can not only be understood as event reporting statements, but also as ascriptions (...) of dispositions or tendencies that may or may not refer to collectives of interacting molecules or even to collectives of interaction events. (shrink)

Studies of the Early Modern debate concerning absolute and relative space and motion often ignore the significance of the concept of true motion in this debate. Even philosophers who denied the existence of absolute space maintained that true motions could be distinguished from merely apparent ones. In this paper, I examine Berkeley's endorsement of this distinction and the problems it raises. First, Berkeley's endorsement raises a problem of consistency with his other philosophical commitments, namely his idealism. Second, Berkeley's (...) endorsement raises a problem of adequacy, namely whether Berkeley can provide an adequate account of what grounds the distinction between true and merely apparent motion. In this paper, I argue that sensitivity to Berkeley's distinction between what is true in the metaphysical, scientific, and vulgar domains can address both the consistency and the adequacy problems. I argue that Berkeley only accepts true motion in the scientific and vulgar domains, and not the metaphysical. There is thus no inconsistency between his endorsement of true motion in science and ordinary language, and his metaphysical idealism. Further, I suggest that sensitivity to these three domains shows that Berkeley possesses resources to give an adequate account of how true motions are discovered in natural science. (shrink)

Molecular biology is a relatively new and very successful branch of science but currently it faces challenges posed by very complex issues that cannot be addressed by a traditional reductionist approach. However, despite its origins in the providential shift of some theoretical physicists to biology, currently molecular biology is immersed in a blind trend in which high-throughput technology, able to generate trillions of data, is becoming the leading edge of a discipline that has traded rational and critical thinking (...) for computer power, data crunching and statistics in hope of finding, once more, its way. However, the complex questions facing MB may only be solved by a paradigm shift in the causal way of thinking, so that complex, emergent, non-linear phenomena may be effectively understood in top-down and not in bottom-up terms. (shrink)

I examine the reasons Aristotle presents in Physics VIII 8 for denying a crucial assumption of Zeno’s dichotomy paradox: that every motion is composed of sub-motions. Aristotle claims that a unified motion is divisible into motions only in potentiality (δυνάμει). If it were actually divided at some point, the mobile would need to have arrived at and then have departed from this point, and that would require some interval of rest. Commentators have generally found Aristotle’s reasoning unconvincing. Against (...) David Bostock and Richard Sorabji, inter alia, I argue that Aristotle offers a plausible and internally consistent response to Zeno. I defend Aristotle’s reasoning by using his discussion of what to say about the mobile at boundary instants, transitions between change and rest. There Aristotle articulates what I call the Changes are Open, Rests are Closed Rule: what is true of something at a boundary instant is what is true of it over the time of its rest. By contrast, predications true of something over its period of change are not true of the thing at either of the boundary instants of that change. I argue that this rule issues from Aristotle’s general understanding of change, as laid out in Phys. III. It also fits well with Phys. VI, where Aristotle maintains that there is a first boundary instant included in the time of rest, but not a “first in which the mobile began to change.” I then show how this rule underlies Aristotle’s argument that a continuous motion cannot be composed of actual sub-motions. Aristotle distinguishes potential middles, points passed through en route to a terminus, from actual middles. The Changes are Open, Rests are Closed Rule only applies to actual middles, because only they are boundaries of change that the mobile must arrive at and then depart from. On my reading, Aristotle argues that the instant of arrival, the first instant at which the mobile has come to be at the actual middle, cannot belong to the time of the subsequent motion. If it did, the mobile would already be moving towards the next terminus and thus, per Phys. VI 6, would have already left. But it cannot have moved away from the midpoint at the very same moment it has arrived there. This means that the instant of arrival must be separated from the time of departure by an interval of rest. I show how Aristotle’s reasoning applies generally to rule out any continuous reflexive motion or continuous complex rectilinear motion. On my interpretation, however, the argument does not apply to every change of direction. When, as in the case of projectile motion, multiple movers and their relative powers explain why the mobile changes directions, distinct sub-motions are not involved. Aristotle holds that such motions cannot be continuous, not because they involve intervals of rest, but because they involve multiple causes of motion. My interpretation of the Changes are Open, Rests are Closed Rule allows us to make better sense of Aristotle’s argument than any previous interpretation. (shrink)

Austere relationism rejects the orthodox analysis of hallucinations and illusions as incorrect perceptual representations. In this article, I argue that illusions of optimal motion present a serious challenge for this view. First, I submit that austere-relationist accounts of misleading experiences cannot be adapted to account for IOMs. Second, I show that any attempt at elucidating IOMs within an austere-relationist framework undermines the claim that perceptual experiences fundamentally involve relations to mind-independent objects. Third, I develop a representationalist model of IOMs. (...) The proposed analysis combines two ideas: Evans' dynamic modes of presentation and Fine's relational semantics for identity. (shrink)

This paper is concerned with the senses in which paintings do and do not depict various temporal phenomena, such as motion, stasis and duration. I begin by explaining the popular – though not uncontroversial – assumption that depiction, as a pictorial form of representation, is a matter of an experiential resemblance between the pictorial representation and that which it is a depiction of. Given this assumption, I illustrate a tension between two plausible claims: that paintings do not depict (...) class='Hi'>motion in the sense that video recordings do, and that paintings do not merely depict objects but may depict those objects as engaged in various activities, such as moving. To resolve the tension, I demonstrate that we need to recognise an ambiguity in talk of the appearance of motion, and distinguish between the depiction of motion and the depiction of an object as an object that is moving. Armed with this distinction, I argue that there is an important sense in which paintings depict neither motion, duration, nor – perhaps more controversially – stasis. (shrink)

Molecular clocks based upon amino acid sequences in proteins have played a major role in the clarification of evolutionary phylogenies. Creationist criticisms of these methods sometimes rely upon data that might initially seem to be paradoxical. For example, human cytochrome c differs from that of an alligator by 13 amino acids but differs by 14 amino acids from a much more closely related primate, Otolemur garnettii. The apparent anomaly is resolved by taking into consideration the variable substitution rate of (...) cytochrome c, particularly among primates. This paper traces some of the history of extensive research into the topic of rate heterogeneity in cytochrome c including data from cytochrome c pseudogenes. (shrink)

In Critique of Pure Reason Kant speaks about motion, as action of the subject in connection with the actions by which we describe a space, such as drawing a line or constructing a circle. In a 1992-paper in Kant-Studien I argued that this is one important piece of textual evidence for the so-called externalist interpretation, according to which the transcendental conditions of experience and indeed all the a priori elements in Kant’s system are public, depending upon overt action. Konstantin (...) Pollok has criticized my reading, arguing that the relevant use of the term “motion” here is just metaphorical, and considering some central Kantian doctrines that he thinks refutes the externalist interpretation. The present paper defends the externalist interpretation against Pollok’s charges. (shrink)

This article proves that the motion principle of philosophical physics (every thing moved is moved by another) is truly compatible with the inertia principle of mathematical physics (Newton's First Law).

Manfred Eigen employs the terms language and communication to explain key recombination processes of DNA as well as to explain the self-organization of human language and communication: Life processes as well as language and communication processes are governed by the logic of a molecular syntax, which is the exact depiction of a principally formalizable reality. The author of the present contribution demonstrates that this view of Manfred Eigen’s cannot be sufficiently substantiated and that it must be supplemented by an (...) approach based on linguistic pragmatics. (shrink)

In his essay “Things Do Not Move,” Sengzhao (374?−414 CE), a prominent Chinese Buddhist philosopher, argues for the thesis that the myriad things do not move in time. This view is counter-intuitive and seems to run counter to the Mahayana Buddhist doctrine of emptiness. In this book chapter, I assess Sengzhao’s arguments for his thesis, elucidate his stance on the change/nonchange of things, and discuss related problems. I argue that although Sengzhao is keen on showing the plausibility of the thesis, (...) he actually views the myriad things as both changing and unchanging and upholds the nonduality of motion and rest. In fact, the nonmoving thesis follows from the discernment that things change from moment to moment without there being any enduring stuff in the process. Among philosophical works that confer a higher ontological status on nonchange over change, Sengzhao’s essay is unique and well worth pondering. (shrink)

This paper discusses a somewhat neglected reading of the second chapter of Nāgārjuna’s Mūlamadhyamakakārikā, arguing that the main focus of a crucial part is a particular theory of properties and their relation to individuals they instantiate, rather than the refutation of specific assumptions about the nature of space and time. Some of Nāgārjuna’s key arguments about motion should be understood as argument templates in which notions other than mover, motion, and so forth could be substituted. The remainder of (...) the discussion of motion does not serve quasi-Zenonian purposes either but uses motion as a principal example of change and considers the soteriological problems of the subject moving (gati) through transmigratory existence (saṃsāra). I attempt to show how this interpretation coheres with Nāgārjuna’s overall philosophical project. (shrink)

The philosophical debate around the impact of machine learning in science is often framed in terms of a choice between AI and classical methods as mutually exclusive alternatives involving difficult epistemological trade-offs. A common worry regarding machine learning methods specifically is that they lead to opaque models that make predictions but do not lead to explanation or understanding. Focusing on the field of molecular biology, I argue that in practice machine learning is often used with explanatory aims. More specifically, (...) I argue that machine learning can be tightly integrated with other, more traditional, research methods and in a clear sense can contribute to insight into the causal processes underlying phenomena of interest to biologists. One could even say that machine learning is not the end of theory in important areas of biology, as has been argued, but rather a new beginning. I support these claims with a detailed discussion of a case study involving gene regulation by microRNAs. (shrink)

Modern philosophy of physics debates whether motion is absolute or relative. The debate began in the 1600s, so it deserves a close look here. Primarily, it was a controversy in metaphysics, but it had epistemic aspects too. I begin with the former, and then touch upon the latter at the end.

This chapter focuses on the appetite for self-preservation and its central role in Francis Bacon’s natural philosophy. In the first part, I introduce Bacon’s classification of universal appetites, showing the correspondences between natural and moral philosophy. I then examine the role that appetites play in his theory of motions and, additionally, the various meanings accorded to preservation in this context. I also discuss some of the sources underlying Bacon’s ideas, for his views about preservation reveal traces of Stoicism, Telesian natural (...) philosophy, the natural law tradition, as well as late-scholastic ideas. Bacon assumes the existence of two kinds of preservation: self-preservation and preservation of the whole. The appetite through which the whole preserves itself overpowers individual appetites for self-preservation. In Bacon’s theory of motions, the primacy of global preservation – that is, the preservation of the whole – is evidenced by the way matter resists being annihilated, while self-preservation at a local and particular level is revealed through other kinds of motion. Bacon’s notion of appetite reflects a specific metaphysics of matter and motion, in which the preservation of natural bodies follows teleological patterns shared by both nature and humanity: the preservation of the whole is the highest goal, both in moral and natural philosophy. In this chapter, I argue that in Bacon’s natural philosophy different kind of things, including nature and humans, are ruled by patterns that are constitutive of correlated orders, neither of which is reducible to the other: there is no priority of the natural order over the moral, or vice versa. Thus, at a more general level, both are expressions of the same type of divinely imposed, law-like behaviour. (shrink)

A plausible reading of Berkeley’s view of voluntary motion is occasionalism; this, however, leads to a specious conclusion against his argument of human action. Differing from an unqualified occasionalist reading, I consider the alternative reading that Berkeley is a conservationist regarding bodily motion by the human mind at will. That is, finite minds (spirits) immediately cause motions in their body parts, albeit under the divine conservation. My argument then comports with the conservationist reading from three perspectives: (i) theodicy (...) that the human mind is held liable for sinful actions; (ii) an account of the human mind influencing other minds; and (iii) an improper but necessary directing principle of the human mind. This article is a stepping stone to grasping why the conservationist reading is more coherent than the occasionalist one. (shrink)

Aristotle defines motion as such: ‘The fulfillment of what exists potentially, in so far as it exist potentially, is motion.’ (Phy., Γ, 1, 201a10-11) He defines it again in the same chapter: ‘It is the fulfillment of what is potential when it is already fully real and operates not as itself but as movable, that is motion. What I mean by ‘as’ is this: Bronze is potentially a statue. But it is not the fulfillment of bronze as (...) bronze which is motion.’ (Phy., Γ, 1) 2) Motion: not a real thing Aristotle believes that ‘there is no such thing as motion over and above the things’ that is supposed to mean that motion cannot be something else than his categories: ‘It is always with respect to substance or to quality or to quantity or to place that what changes changes. But it is impossible to find anything common to these which is neither ‘this’ not quantum nor quale nor any of the other predicates. Hence neither will motion and change have reference to something over and above the things mentioned, for there is nothing over and above them.’ (Phy., Γ, 1, 200b32-201a3) In fact, it is what is moved that is a reality for Aristotle and not the motion itself: ‘Motion is known because of that which is moved, locomotion because of that which is carried. What is carried is a real thing, the movement is not.’ (Phy., Δ, 11) 3) Three items in each motion Aristotle distinguishes three items in each motion (Phy., E, 4): a) ‘That which’ moves; (Note: It is this item that makes a motion a unitary motion. (Phy., Δ, 11)) e.g. a man or gold b) ‘That in which’ the movement occurs; e.g. a place or an affection c) ‘That during which’ the movement takes place; e.g. time Based on the second item, Aristotle distinguishes three kinds of motion: quantitative, qualitative and local which are in respect of the three categories of quantity, quality and place. (Phy., E, 1) However, Aristotle speaks of four things in respect of which change takes place adding substance to the three mentioned categories. (Phy., Γ, 1, 200b32-35) It seems it is based on the differentiation of that in which motion takes place in these four types that Aristotle distinguishes four kinds of motion. (Phy., Γ, 1, 201a11-15): a) Alteration: the motion of what is alterable qua alterable b) Increase and decrease: the motion of what can be increased and what can be decreased c) Coming to be and passing away: the motion of what come to be and pass away d) Locomotion: the motion of what can be carried away Alteration happens in qualities, increase and decrease in quantities, coming to be and passing away in substances and locomotion in place. 4) Problem of motion as an element Discussing why Pythagoreans put motion in their column of indefinites, Aristotle somehow hints to the problem of understanding motion due to its non-elemental character: ‘The reason why they put motion into these genera is that it is thought to be something indefinite and the principles in the second column are indefinite because they are privative: none of them is either ‘this’ or ‘such’ or comes under any of the other modes of predication. The reason in turn why motion is thought to be indefinite is that it cannot be classed simply as a potentiality or as an actuality- a thing that is merely capable of having a certain size is not undergoing change, nor yet a thing that is actually of a certain size, and motion is thought to be a sort of actuality, but incomplete. The reason for this view being that the potential whose actuality it is is incomplete. This is why it is hard to grasp what motion is. It is necessary to class it with privation or with potentiality or with sheer actuality, yet none of these seems possible. There remains then the suggested mode of definition, namely that it is a sort of actuality, or actuality of the kind described, hard to grasp, but not incapable of existing.’ (Phy., Γ, 2, 201b24-) It becomes a real difficulty when it is asked whether the motion is in the mover or in the movable: ‘The solution of the difficulty that is raised about the motion-whether it is in the movable- is plain. It is the fulfillment of this potentiality, and by the action of that which has the power of causing motion; and the actuality of that which has the power of causing motion is not other than the actuality of the movable, for it must be the fulfillment of both. A thing is capable of causing motion because it can do this, it is a mover because it actually does it. But it is on the movable that it is capable of acting. Hence there is a single actuality of both alike, just as one to two and two to one are the same interval, and the steep ascent and the steep descent are one- for these are one and the same, although they can be described in different ways. So it is with the mover and the moved.’ (Phy., Γ, 3) This is not, however, the solution: ‘This view has a dialectical difficulty. Perhaps it is necessary that the actuality of the agent and that of the patient should not be the same. The one is ‘agency’ and the other ‘patiency’; and the outcome and the completion of the one is an ‘action’, that of the other a ‘passion.’ Since then they are both motions, we may ask: in what are they, if they are different? Either (a) both are in what is acted on and moved, or (b) the agency is in the agent and the patiency in the patient. … Now in alternative (b), the motion will be in the mover, for the same statement will hold of ‘mover’ and ‘moved.’ Hence either every mover will be moved, or, through having motion, it will not be moved. If on the other hand (a) both are in what is moved and acted on- both the agency and the patiency (e.g. both teaching and learning, though they are two, in the learner), then, first, the actuality of each will not be present in each, and, a second absurdity, a thing will have two motions at the same time. How will there be two alterations of quality in one subject towards one definite quality? The thing is impossible: the actualization will be one.’ (Phy., Γ, 3) This leads Aristotle to another problem, the problem of one identical actualization for two different things: ‘But (someone will say) it is contrary to reason to suppose that there should be one identical actualization of two things which are different in kind. Yet there will be, if teaching and learning are the same, and agency and patiency. To teach will be the same as to learn, and to act the same as to be acted on- the teacher will necessarily be learning everything that he teaches, and the agent will be acted on. One may reply: (1) It is not absurd that the actualization of one thing should be in another. Teaching is the activity of a person who can teach, yet the operation is performed on some patient- it is not cut adrift from a subject, but is of A on B. (2) There is nothing to prevent two things having one and the same actualization, provided the actualizations are not described in the same way, but are related as what can act on what is acting. (3) Nor is it necessary that the teacher should learn, even if to act and to be acted on are one and the same, provided they are not the same in definition (as ‘raiment’ and ‘dress’), but are the same merely in the sense in which the road from Athens to Thebes are the same, as has been explained above.’ (Phy., Γ, 3) And he continues: ‘For it is not things which are in a way the same that have all their attributes the same, but only such as have the same definition. But indeed it by no means follows from the fact that teaching is the same as learning, that to learn is the same as to teach, any more than it follows from the fact there is one distance between two things which are at a distance from each other, that the two vectors AB and BA, are one and the same. To generalize, teaching is not the same as learning, or agency and patiency, in the full sense, though they belong to the same subject, the motion; for the ‘actualization’ of X in Y’ and the ‘actualization of Y through the actualization of X’ differ in definition.’ (Phy., Γ, 3) . (shrink)

Motion—and, in particular, local motion or change in location—plays a central role in Kenelm Digby’s natural philosophy and in his arguments for the immateriality of the soul. Despite this, Digby’s account of what motion consists in has yet to receive much scholarly attention. In this paper, I advance a novel interpretation of Digby on motion. According to it, Digby holds that for a body to move is for it to divide from and unify with other bodies. (...) This is a view of motion—as change in relations of parthood—that Alison Peterman attributes to Digby’s contemporary and acquaintance, Margaret Cavendish. Having shown that Digby’s presentation of the view predates Cavendish’s by more than a decade, I make a case that Digby’s work influenced Cavendish’s on this topic. In developing and defending my reading, I consider to what extent the Digbean account of motion and the arguments for it accord with the ideals of the mechanical philosophy emerging in the early modern period. (shrink)

We study the acceleration and collisions of rigid bodies in special relativity. After a brief historical review, we give a physical definition of the term ‘rigid body’ in relativistic straight line motion. We show that the definition of ‘rigid body’ in relativity differs from the usual classical definition, so there is no difficulty in dealing with rigid bodies in relativistic motion. We then describe The motion of a rigid body undergoing constant acceleration to a given velocity.The acceleration (...) of a rigid body due to an applied impulse.Collisions between rigid bodies. (shrink)

This paper offers a reconstruction of the interpretations of Descartes’s ideas of place and motion by Dutch Cartesians (Henricus Regius, Johannes de Raey, Johannes Clauberg, and Christoph Wittich). It does so by focusing on the reading of Descartes’s Principia philosophiae (1644) offered, in particular, by the dictated commentaries on it. It is shown how such commentaries bring to the light new potential Aristotelian-Scholastic sources of Descartes, and the different ways Dutch Cartesians brought to the fore, also with the help (...) of such sources, the rationale of the Cartesian text: in doing so, they constituted a philosophical school. (shrink)

Existen inconsistencias fundamentales entre el paradigma de la biología molecular y el paradigma de la física contemporánea y, por lo tanto, el marco conceptual vigente en la biología molecular resulta insuficiente para abordar las cuestiones del origen y desarrollo de la forma y organización biológicas.

This paper examines Descartes' problematic relational theory of motion, especially when viewed within the context of his dynamics, the Cartesian natural laws. The work of various commentators on Cartesian motion is also surveyed, with particular emphasis placed upon the recent important texts of Garber and Des Chene. In contrast to the methodology of most previous interpretations, however, this essay employs a modern "spacetime" approach to the problem. By this means, the role of dynamics in Descartes' theory, which has (...) often been neglected in favor of kinematic factors, is shown to be central to finding a solution to the puzzle of Cartesian motion. (shrink)

Spacetime and motion are interconnected concepts. A better understanding of motion leads to a better understanding of spacetime. We use the historical critical analysis of the various theoretical proposals on motion in search of clues ignored. The prediction of the general relativity that the motion occurs in the static gravitational field is not valid because the motion always occurs in a given medium as vacuum, atmosphere, water, etc. The concept of motion and the equations (...) of the special and general relativity, as the theory of Galilee-Newton reduce motion elements to particle and spacetime. In this paper, we present the medium (in special, the quantum vacuum), as the third essential element of motion, inseparable of spacetime since it is its material support of which the spacetime is its structural form, and we analyse its consequences in the theories of spacetime. Our contribution is declare, that the spacetime itself does not exist, or is a relational property of matter, but a structural property of matter. (shrink)

In this work, polystyrene/waste tires composites were prepared using the melt-mixing method.. The effect of the preparation conditions of the PS/waste tires composite is investigated in this work by using Gel permeation chromatography (GPC) technique. Stability at elevated temperatures were found to increase with the addition of waste tires to PS as confirmed by the results. GPC results indicate that the preparation conditions of the PS/waste tires composite has no effect on the Ps chains as indicated by GPC technique. The (...) signals of the GPC for unfilled and filled PS are similar. That evidences no thermo-mechanical chain degradation is taken place during the addition of the waste tires under the conditions of the melt-mixing process . (shrink)

Cross cultural studies have played a pivotal role in elucidating the extent to which behavioral and mental characteristics depend on specific environmental influences. Surprisingly, little field research has been carried out on a fundamentally important perceptual ability, namely the perception of biological motion. In this report, we present details of studies carried out with the help of volunteers from the Mundurucu indigene, a group of people native to Amazonian territories in Brazil. We employed standard biological motion perception tasks (...) inspired by over 30 years of laboratory research, in which observers attempt to decipher the walking direction of point-light (PL) humans and animals. Do our effortless skills at perceiving biological activity from PL animations, as revealed in laboratory settings, generalize to people who have never before seen representational depictions of human and animal activity? The results of our studies provide a clear answer to this important, previously unanswered question. Mundurucu observers readily perceived the coherent, global shape depicted in PL walkers, and experienced the classic inversion effects that are typically found when such stimuli are turned upside down. In addition, their performance was in accord with important recent findings in the literature, in the abundant ease with which they extracted direction information from local motion invariants alone. We conclude that the effortless, veridical perception of PL biological motion is a spontaneous and universal perceptual ability, occurring both inside and outside traditional laboratory environments. (shrink)

Margaret Cavendish (1623-1673) argues that when someone throws a ball, their hand does not cause the ball to move. Instead, the ball moves itself. In this chapter, I reconstruct Cavendish’s argument that material things—like the ball—are self-moving. Cavendish argues that body-body interaction is unintelligible. We cannot make sense of interaction in terms of the transfer of motion nor the more basic idea that one body acts in another body. Assuming something moves bodies around, Cavendish concludes that bodies move themselves. (...) Still, Cavendish needs to explain why bodies appear to causally interact even if they do not really. Balls do not usually throw themselves without a helping hand. I offer a new reading of the way bodies respond to their external circumstances in terms of prerequisites or enabling conditions. (shrink)

The type-level abstraction is a formal way to represent molecular structures in biological practice. Graphical representations of molecular structures of biological objects are also used to identify functional processes of things. This paper will reveal that category theory is a formal mathematical language not only to visualize molecular structures of biological objects as type-level abstraction formally but also to understand how to infer biological functions from the molecular structures of biological objects. Category theory is a toolkit (...) to understand biological knowledge at the type-level formally, not individual token-level, as well as typical heuristic strategies in molecular biology. (shrink)