ENGLISH Blumenbergs Metaphorology is offered as an hermeneutical alternative to heideggerian existential hermeneutic. It implies that philosophical anthropology –as we find her in Gehlen, Plessner and others– achieves onthological standing, and it’s developed as a history of great metaphers, that seems to support the history of ideas.

SPANISH Nuestra época se caracteriza por la casi indiscutida vigencia del modelo de economía de mercado. Esto coincide con un esfuerzo notorio por ocultar la presencia de la muerte, movido por la aguda percepción de la contigencia que emerge en la Modernidad. La lógica subyacente a estos elementos es que la monetarización puede entenderse como una respuesta al acrecentamiento de la conciencia de la muerte. Esto tiene lugar en el contexto de una nueva comprensión de sí marcada por la importancia (...) de la memoria. Así, la lucha del hombre moderno contra la conciencia de la muerte se desarrolla en los frentes de la acumulación de riquezas, y de la memoria. -/- ENGLISH One of the main features of our time is the presence of a widespread market economy. At the same time, notororious efforts to conceal the presence of death can be easily identified in our society; they are likely driven by an acute perception of finitude originated in Modernity. The rationale behind both aspects is that monetarisation can be regarded as a reaction to the increasing awareness of death. All of this is framed by a new self-understanding, heavily characterized by the relevance of memory. Thus, the fight of the modern man against the awareness of death is led in both fronts of wealth accumulation and memory. (shrink)

In this paper I argue that some human reproductive genome editing interventions can be therapeutic in nature, and thus that it is false that all such interventions just create healthy individuals. I do this by showing that the conditions established by a therapy definition are met by certain reproductive genome editing interventions. I then defend this position against two objections: (a) reproductive genome editing interventions do not attain one of the two conditions for something to be a therapy, and (b) (...) some reproductive genome editing interventions are therapeutic but in a nonstandard way. In the Conclusion I call for a more nuanced discussion of the nature of reproductive genome editing interventions. (shrink)

In response to the COVID‐19 pandemic philosophers and governments have proposed scarce resource allocation guidelines. Their purpose is to advise healthcare professionals on how to ethically allocate scarce medical resources. One challenging feature of the pandemic has been the large numbers of patients needing mechanical ventilatory support. Guidelines have paradigmatically focused on the question of what doctors should do if they have fewer ventilators than patients who need respiratory support: which patient should get the ventilator? There is, however, an important (...) higher level allocation problem. Namely, how are we to ethically distribute newly obtained ventilators across hospitals: which hospital should get the ventilator(s)? In this paper, we identify a set of principles for allocating newly obtained ventilators across hospitals. We focus particularly on low and middle income countries, who frequently have limited pre‐existing intensive care capacity, and have needed to source additional ventilators. We first provide some background. Second, we argue that the main population healthcare aim during the COVID‐19 pandemic should be to save the most lives. Next, we assess a series of potential heuristics or principles that could be used to guide allocation: allocation to the most densely populated cities, random allocation, allocation based on the ratio of patients to ICU personnel, prioritisation in terms of intrahospital mortality, prioritisation of younger populations, and prioritisation in terms of population mortality. We conclude by providing a plausible ranking of the principles, while noting a number of epistemological challenges, in terms of how they best further the aim of increasing the probability of saving the most lives. (shrink)

Recent breakthroughs in stem cell differentiation and reprogramming suggest that functional human gametes could soon be created in vitro. While the ethical debate on the uses of in vitro generated gametes (IVG) was originally constrained by the fact that they could be derived only from embryonic stem cell lines, the advent of somatic cell reprogramming, with the possibility to easily derive human induced pluripotent stem cells from any individual, affords now a major leap in the feasibility of IVG derivation and (...) in the scope of their potential applications. In this paper we develop an ethical framework, rooted in recent scientific evidence, to support a robust experimental pipeline that could enable the first-in-human use of IVG. We then apply this framework to the following objectives: (1) a clarification of the genetic parenting options afforded by IVG, along with their ethical underpinnings; (2) a defence of the use of IVG to remedy infertility, broadening their scope to same-sex couples; (3) an assessment of the most far-reaching implications of IVG for multiplex parenting. These include, first, the liberation of parenting roles from the constraints of biological generations in vivo, allowing multiple individuals to engage in genetic parenting together, thus blurring the distinction between biological and social generations. Second, we discuss the conflation of IVG with sequencing technology and its implications for the possibility that prospective parents may choose among a hitherto unprecedented number of potential children. In view of these perspectives, we argue that, contrary to the exhausted paradigm according to which society lags behind science, IVG may represent instead a salient and most visible instance where biotechnological ingenuity could be used in pursuit of social experimentation. (shrink)

Some Comments on de Melo-Martin and Harris.

News about the first baby born after a mitochondrial replacement technique (MRT; specifically maternal spindle transfer) broke on September 27, 2016 and, in a matter of hours, went global. Of special interest was the fact that the mitochondrial replacement procedure happened in Mexico. One of the scientists behind this world first was quoted as having said that he and his team went to Mexico to carry out the procedure because, in Mexico, there are no rules. In this paper, we explore (...) Mexico's rule of law in relation to mitochondrial replacement techniques and show that, in fact, certain instances of MRTs are prohibited at the federal level and others are prohibited at the state level. According to our interpretation of the law, the scientists behind this first successful MRT procedure broke federal regulations regarding assisted fertilization research. (shrink)

In a recent publication Tom Douglas and Katrien Devolder have proposed a new account of genetic parenthood, building on the work of Heidi Mertes. Douglas and Devolder’s account aims to solve, among other things, the question of who are the genetic parents of an individual created through somatic cell nuclear transfer (i.e. cloning): (a) the nuclear DNA provider or (b) the progenitors of the nuclear DNA provider. Such a question cannot be answered by simply appealing to the folk account of (...) genetic parenthood, according to which the genetic parents of an individual are those individuals who produced the egg and sperm, respectively, which fused to create the embryo. It cannot be so as in cloning there is no fertilization as such. In this article I critically examine Douglas and Devolder’s new account of genetic parenthood and demonstrate that it is vulnerable to counterexamples that exploit the lack of a condition specifying that genetic parents should cause a child’s coming into existence. (shrink)

Human eggs for basic, fertility and stem-cell research are in short supply. Many experiments that require their use cannot be carried out at present, and, therefore, the benefits that could emerge from these are either delayed or never materialise. This state of affairs is problematic for scientists and patients worldwide, and it is a matter that needs our attention. Recent advances in chimera research have opened the possibility of creating human/non-human animal chimeras intended for human gamete production (chimeras-IHGP). In this (...) paper, I examine four arguments against the creation of such chimeras and prove that all of them are found wanting. I conclude by showing that there is a strong moral reason for scientists to pursue this research avenue. (shrink)

Abstract Background The first live birth following the use of a new reproductive technique, maternal spindle transfer (MST), which is a mitochondrial replacement technique (MRT), was accomplished by dividing the execution of the MST procedure between two countries, the USA and Mexico. This was done in order to avoid US legal restrictions on this technique. -/- Sources of data Academic articles, news articles, documents obtained through freedom of information requests, laws, regulations and national reports. -/- Areas of agreement MRTs are (...) new reproductive techniques that present novel ethical and legal challenges, since genetic material from three people is employed to create a child. -/- Areas of controversy Could the first MST procedure that culminated in a live birth negatively impact reproductive medicine in Mexico? -/- Growing points The USA and Mexico need specific and clear legislation on MRTs, in order for such techniques not to be governed by prior existing legislation on assisted reproduction that is inadequate for dealing with the new challenges that these techniques present. -/- Areas timely for developing research There is a pressing need for work to be done on the international governance of new reproductive techniques. (shrink)

In 2015 the United Kingdom (UK) became the first nation to legalize egg and zygotic nuclear transfer procedures using mitochondrial replacement techniques (MRTs) to prevent the maternal transmission of serious mitochondrial DNA diseases to offspring. These techniques are a form of human germline genetic modification and can happen intentionally if female embryos are selected during the MRT clinical process, either through sperm selection or preimplantation genetic diagnosis (PGD). In the same year, an MRT was performed by a United States (U.S.)-based (...) physician team. This experiment involved a cross-border effort: the MRT procedure per se was carried out in the US, and the embryo transfer in Mexico. The authors examine the ethics of MRTs from the standpoint of genetic relatedness and gender implications, in places that lack adequate laws and regulation regarding assisted reproduction. Then, we briefly examine whether MRTs can be justified as a reproductive option in the US and Mexico, after reassessing their legalization in the UK. We contend that morally inadequate and ineffective regulations regarding egg donation, PGD, and germline genetic modifications jeopardize the ethical acceptability of the implementation of MRTs, suggesting that MRTs are currently difficult to justify in the US and Mexico. In addition to relevant regulation, the initiation and appropriate use of MRTs in a country require a child-centered follow-up policy and more evidence for its safety. (shrink)

In the first wave of the COVID-19 pandemic, healthcare workers in some countries were forced to make distressing triaging decisions about which individual patients should receive potentially life-saving treatment. Much of the ethical discussion prompted by the pandemic has concerned which moral principles should ground our response to these individual triage questions. In this paper we aim to broaden the scope of this discussion by considering the ethics of broader structural allocation decisions raised by the COVID-19 pandemic. More specifically, we (...) consider how nations ought to distribute a scarce life-saving resource across healthcare regions in a public health emergency, particularly in view of regional differences in projected need and existing capacity. We call this the regional triage question. Using the case study of ventilators in the COVID-19 pandemic, we show how the moral frameworks that we might adopt in response to individual triage decisions do not translate straightforwardly to this regional-level triage question. Having outlined what we take to be a plausible egalitarian approach to the regional triage question, we go on to propose a novel way of operationalising the ‘save the most lives’ principle in this context. We claim that the latter principle ought to take some precedence in the regional triage question, but also note important limitations to the extent of the influence that it should have in regional allocation decisions. (shrink)

RESUMO A alimentação é o fator que mais onera um sistema de produção animal. Assim, a utilização de diferentes estratégias de alimentação dos animais ainda é o grande desafio da nutrição animal, principalmente, levando em consideração as exigências nutricionais de diferentes categorias de ruminantes, em especial bovinos em regiões tropicais, haja vista que a sazonalidade na produção de forragens afeta diretamente a produção bovina, promovendo inadequação no atendimento das exigências nutricionais dos animais principalmente em minerais e vitaminas. Uma alimentação que (...) não atenda as exigências nutricionais dos ruminantes gera prejuízos no sistema de produção, além de, em casos mais graves, ocasionar a perda do animal. Estudos que abordam o efeito e a importância de vitaminas e minerais na nutrição bovina são escassos e necessários. Recentemente a National Research Council (NRC) apresentou novos registros das exigências nutricionais das vitaminas e minerais. Essas alterações proporcionam um impacto econômico significativo em relação à nutrição animal. Nesse sentido, objetivou-se com esta revisão trazer informações acerca de vitaminas e minerais na nutrição de bovinos em pastejo. -/- Palavras-chave: Alimentação animal; forragem; pastagem; requerimentos nutricionais; ruminantes; vitaminas lipossolúveis (Source: AGROVOC). -/- ABSTRACT Animal feed is the factor that most burdens a production system. Thus, the use of different animal feeding strategies is still the great challenge of animal nutrition, taking into account the nutritional requirements of different categories of ruminants, especially cattle in tropical regions, given that seasonality in forage production directly affects cattle production, promoting inadequacy in meeting the nutritional requirements of animals, mainly in minerals and vitamins. A diet that does not meet the nutritional requirements of ruminants generates losses in the production system, in addition to, in more serious cases, causing the loss of the animal. Studies that address the effect and importance of vitamins and minerals in bovine nutrition are scarce and necessary. Recently the National Research Council (NRC) presented new records of the nutritional requirements of vitamins and minerals. These changes provide a significant economic impact on animal nutrition. In this sense, the objective of this review was to bring information about vitamins and minerals in the nutrition of grazing cattle. -/- Keywords: Animal feeding; fat soluble vitamins; forage; nutritional requirements; pasture feeding; ruminants (Source: AGROVOC). -/- REFERÊNCIAS BIBLIOGRÁFICAS -/- 1. Cavalcanti CPL, Silva e Macedo TJ, Gois GC, Menezes VG, Monte APO, Silva AD, Silva DJM, Silva EO, Araújo GGL, Rodrigues RTS, Wischral A, Matos MHT, Queiroz MAA. Licuri oil improves feedlot performance and modifies ruminal fauna of Santa Inês ewes. Liv Sci. 2022; 265:e105093. 2. Busato KC, Chizzotti ML, Rodrigues RTS, Silva TS, Silva IF, Queiroz MAA, Silva KT, Borges JC, Gois GC. Ingestive behavior and growth performance of boer crossbred and indigenous goat kids under different feeding levels in Semiarid Region in Brazil. Trop Agric Res. 2022; 33:299-309. 3. Patton J, Dineen M, Keady TWJ, McGee M, Waters S. Developments in nutrition for pasture-based cattle and sheep systems in Ireland. Irish J Agric Food Res. 2022; 61(1):12-37. 4. McAllister TA, Stanford K, Chaves AV, Evans PR, Figueiredo, EES, Ribeiro G. Nutrition, feeding and management of beef cattle in intensive and extensive production systems. Chapter 5. In: Bazer FW, Lamb GC, Wu G, editors. Animal Agriculture. Sustainability, Challenges and Innovations. 1st ed. Elsevier Inc.: Academic Press; 2020. 5. Byrne L, Murphy RA. 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Paul SH, Usman AA, Gana IN, Manase A, Adeniyi OD, Olutoye MA. Comparative study of mineral and nutritional composition of a multifunctional flora composite formulated from seven medicinal plants and their applications to human health. Eng Techn Open Access J. 2018; 1:137-150. 30. Zhou J, Zhang J, Xue B, Yue S, Yang C, Xue B. Effects of premating calcium and phosphorus supplementation on reproduction efficiency of grazing yak heifers. Anim. 2021; 11:1-9. 31. Harder H, Khol-Parisini A, Metzler-Zebeli BU, Klevenhusen F, Zebeli Q. Treatment of grain with organic acids at 2 different dietary phosphorus levels modulates ruminal microbial community structure and fermentation patterns in vitro. J Dairy Sci. 2015; 98:8107–8120. 32. Jain RK, Mudgal V. Phosphorus deficiency influences rumen microbial activity: Review. Int J Zoo Anim Biol. 2021; 4:1-9. 33. Barreto JC, Branco AF, Santos GT, Magalhães VJA, Coneglian SMC, Teixeira S. Avaliação dos efeitos de fontes de fósforo na dieta sobre parâmetros do meio ruminal e eficiência de síntese microbiana, digestibilidade dos nutrientes e fósforo plasmático em bovinos. Rev Bras Zootec. 2009; 38:760-769. 34. Yamada S, Inaba M. Potassium metabolism and management in patients with CKD. Nutr. 2021; 13:1-19. 35. Martinsen TC, Fossmark R, Waldum HL. The phylogeny and biological function of gastric juice—Microbiological consequences of removing gastric acid. Int J Mol Sci. 2019; 20:1-22. 36. González FHD, Silva SC. Minerais e vitaminas no metabolismo animal. 1st ed. Porto Alegre: Universidade Federal do Rio Grande do Sul; 2019. 37. Melo RR, Gonçalves SLS, Baccarin FJB, Vasconcelos WA, Miranda SC. Influência de altas dosagens de cloreto de potássio no desenvolvimento de espécies em cultivo hidropônico. Pubvet. 2020; 14:1-9. 38. Araújo WAG, Rostagno HS, Albino LFT, Carvalho TA, Ribeiro Neto AC. Potássio na nutrição animal. Rev Eletr Nutr. 2010; 7:1280-1291. 39. NRC. National Research Council. Nutrient requeriments of dairy cattle. 8th ed. Washinton, DC.: The National Academy Press; 2021. 40. Palomares RA. Trace Minerals Supplementation with Great Impact on Beef Cattle Immunity and Health. Anim. 2022; 12:e2839. 41. Tariq M, Abbas G, Ahmad S, Mustafa R, Sultan H, Abdullah M, Hussain I, Arshad M, Cheema UB, Hassan SU. Effect of supplementation of minerals on the productive and reproductive performance of lactating cattle and buffalo. Pakistan J Sci. 2022; 74:e425. 42. Pagno KCA Barbosa JD, Salvarani FM, Bomjardim HA, Faial KCF, Souza RS, Gava A, Perotta JH, Barros Filho IR. Micromineral concentrations (copper, cobalt, iron, molybdenum and zinc) in the liver of dairy cows from Campos Gerais Region, Paraná state, Brazil. Pesq Vet Bras. 2023; 43:e07137. 43. Jeong H, Vacanti NM. Systemic vitamin intake impacting tissue proteomes. Nut Met. 2020; 17:1-16. 44. Spears JW, Weiss WP. Invited Review: Mineral and vitamin nutrition in ruminants. Appl Anim Sci. 2014; 30:180-191. 45. Erickson PS, Kalscheur KF. Nutrition and feeding of dairy cattle. Chapter 9. (pp. 157-180). In: Bazer FW, Lamb GC, Wu G, editors. Animal Agriculture. Sustainability, Challenges and Innovations. 1st ed. Elsevier Inc.: Academic Press; 2020. 46. Kareem MM, Jabir MS. Vitamins. Chapter 3. In: Imran M, Imran A, editors. Malnutrition. 1st ed. London, UK.: IntechOpen; 2020. 47. Akram M, Munir N, Daniyal M, Egbuna C, Găman MA, Onyekere PF, et al. Vitamins and minerals: Types, sources and their functions. Chapter 9. (pp 149–172). In: Egbuna C, Tupas GD, editors. Functional foods and nutraceuticals. Switzerland, AG.: Springer, Cham; 2020. 48. Marino CT, Medeiros SR. Minerais e vitaminas na nutrição de bovinos de corte. Chapter 6. (pp. 79-93). In. Medeiros SR, Gomes RC, Bungenstab DJ, editors. Nutrição de bovinos de corte: fundamentos e aplicações. Brasília, DF: Embrapa; 2015. 49. Hodnik JJ, Ježek J, Starič J. A review of vitamin D and its importance to the health of dairy cattle. J Dairy Res. 2020; 87:84–87. 50. Alves EM, Pedreira MS, Santana CA, Silva FF. Nutrição vitamínica de vacas leiteiras. Pubvet. 2008; 2:1-17. 51. Jiang Q, Lin L, Xie F, Jin W, Zhu W, Wang M, et al. Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants. Microb. 2022; 10:1-16. 52. Magan JB, O’Callaghan TF, Zheng J, Zhang L, Mandal R, Hennessy D, et al. Effect of diet on the vitamin B profile of bovine milk-based protein ingredients. Foods. 2020; 9:1-17. 53. Pinedo LA, Berenchtein B, Selem ASMA. Estudo dos processos bioquímicos da fermentação, degradação e absorção de nutrientes dos alimentos em ruminantes. Pubvet. 2008; 2:1-10. 54. DA SILVA, Emanuel Isaque Cordeiro. Formulação e Avaliação de Suplemento Mineral Para Caprinos. Instrução Técnica Para o Produtor Rural de Pernambuco, v. 3, n. 1, p. 1-4, 2023. 55. DA SILVA, Emanuel Isaque Cordeiro. Nutrição Sobre a Reprodução e Fertilidade dos Bovinos. Emanuel Isaque Cordeiro da Silva, 2021. 56. DA SILVA, Emanuel Isaque Cordeiro. Suplementação e formulação de sal mineral e mistura múltipla para bovinos. Revista Universitária Brasileira, v. 2, n. 1, 2024. (shrink)

El presente texto busca difundir a un público más amplio el pensamiento del escritor e intelectual peruano Manuel González Prada (1844-1918), uno de los introductores del positivismo y del anarquismo en el Perú, quien ejerció una notable influencia sobre varios pensadores y literatos peruanos de comienzos del siglo XX, como José Carlos Mariátegui, Víctor Raúl Haya de la Torre, César Vallejo, Jorge Basadre, entre otros. En ese sentido, mostraremos los juicios e ideas de Gonzalez Prada referidas a la relación (...) entre saber científico y poder político, enmarcado en un proyecto de emancipación social y cultural. (shrink)

RELAÇÃO E EFEITOS BIOQUÍMICO-NUTRICIONAIS SOBRE OS CISTOS OVARIANOS EM VACAS Emanuel Isaque Cordeiro da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim [email protected] ou [email protected] WhatsApp: (82)98143-8399 11. CISTOS OVÁRICOS Os cistos são cavidades anormais que às vezes possuem conteúdo de fluido biológico, ou podem ser cavidades ocas, com paredes sólidas refratárias à maioria dos compostos endógenos. Formam-se como alterações patológicas das células luteais ou foliculares do estroma ovárico. A presença de cistos altera o ciclo estral e obriga a (...) realização de tratamentos exógenos para remover o mesmo, fazendo com que a atividade cíclica da gônada retome sua normalidade (HATLER, et al. 2006). Alguns fatores de origem nutricional, tanto por deficiência de alguns compostos, como por excesso no fornecimento de outros, têm sido considerados como causas potenciais dos cistos, entre os principais fatores nutricionais podemos citar: 11.1 Fito-toxidade/fitoestrogênios Compostos vegetais, tais como plantas com elevado teor de flavonoides estrogênicos, encontram-se sob a forma de glicosídeos e têm a capacidade para modificar os processos reprodutivos devido à sua semelhança com os núcleos esteroides de hormônios femininos; são substâncias estruturais e funcionalmente semelhantes ao 17-ß-estradiol ou que produz efeitos estrogênicos (MENDOZA, et al. 2001). Pouco se sabe sobre os estrogênios presentes nas plantas e os níveis de fito-toxidade dos mesmos, logo na prática torna-se algo difícil de ser observado e atacado. Porém, a nível laboratorial, caso haja alguma complicação que afete o animal para além das capacidades reprodutivas, um diagnóstico aprofundado é o mais indicado. 11.2 Minerais 11.2.1 Iodo (I) Alimentos com baixo teor de iodo, provocam estros silenciosos nos animais e aumentam a incidência de quistos ováricos. O I é parte da molécula de tiroxina que estimula a produção de ATP na mitocôndria, a deficiência reduz a captação de oxigênio o que determina uma diminuição no metabolismo energético. Na tireoide existe um complexo de proteína-iodo, chamado tiroglobulina, essa molécula é uma glicoproteína. A maioria do I é reduzida a iodo inorgânico no trato gastrointestinal e a sua absorção é imediata. A função principal da tireoide é acumular I e fixá-lo, formando hormônios da tireoide sob o controle da adenohipófise por secreção (TSH). O I é convertido em iodeto no trato intestinal e então é transportado para a tireoide, aqui as células foliculares o prendem com efetividade através de um processo de transporte ativo, contra um gradiente de concentração, estimulado por TSH. Uma vez que as hormonas da tireoide controlam o metabolismo, uma deficiência em I diminui a taxa metabólica do organismo, isso afeta indiretamente a reprodução, uma vez que o funcionamento irregular da tireoide afeta a formação de lipídios, esses necessários para a produção de hormônios esteroides (estrogênios) e estes por sua vez influenciam a síntese das prostaglandinas F2-alfa necessária para o processo de luteólise o que faz com que o corpo lúteo não se rompa, perdure e forme um cisto. O I presente no alimento do animal deve estar presente e obedecer o intervalo de 0,34 a 0,88 mg/kg de MS em todos os alimentos que o animal viera a ingerir, seja forragens ou rações. A forma de suplementação são as mais conhecidas, via volumoso, concentrado, água ou pelo sistema SMI. 11.2.2 Manganês (Mn) Níveis elevados de manganês na dieta levam à depleção da absorção de ferro, bem como de outros minerais necessários para a síntese, metabolismo, ativação de enzimas e absorção de outros minerais. Essas interações com outros minerais e o papel do excesso de manganês na inibição da síntese dos precursores de hormonas necessárias para a reprodução, bem como dos metabolitos gerados durante o desdobramento ruminal são representados de forma indireta. Para além do efeito antagônico com outros minerais e enzimas, níveis elevados de manganês provocam uma alteração na população da flora ruminal, o que prejudica a produção de ácido propiônico e butírico a nível ruminal, tendo um efeito negativo no metabolismo dos lipídios com uma subsequente baixa de energia (derivado do metabolismo graxo diminuído ou inibido) e também da síntese de ácidos graxos. Por esta última razão, ocorre uma diminuição na síntese das hormonas esteroides, as quais, não estando presentes em níveis adequados, geram problemas no ciclo estral, uma vez que estas hormonas são essenciais para a síntese das prostaglandinas (PGF2-α) que são necessários para a lise do corpo lúteo, com sua posterior persistência, terminando na formação de um cisto luteal. Como sempre falado nos capítulos dessa compilação de trabalhos, o composto Mn é mais um mineral imprescindível para a alimentação do animal, manutenção normal dos seus mecanismos fisiológicos e relações com outros minerais. Sua disponibilidade para o animal deve ser de 12 a 50 mg/kg de MS das forragens, ou a mesma quantidade no conteúdo da ração balanceada. É um elemento que pode ser colocado na água para absorção pelos animais ou através da suplementação mineral injetável (SMI). 11.2.3 Sódio (Na) Os sinais de deficiência de Na são inespecíficos, mas os mais expressivos são sobre o crescimento e produção leiteira. Numa diminuição do consumo de Na, o organismo ativa os mecanismos de conservação mediados pela liberação de aldosterona que aumenta a reabsorção a nível dos túmulos renais deste mineral. A deficiência de Na afeta a produção de muco cervical, com consequências como problemas na formação de espermatozoides e aumento das infecções uterinas. Dado que a deficiência de Na é rara, apenas os sintomas clínicos desta deficiência mineral podem ser vagamente descritos é k caso da dificuldade de concepção, distorcias e bezerros fracos ao nascimento, além da inatividade ovárica e maior incidência de retenção de placenta. As causas de tais alterações foram motivo de numerosos estudos com resultados contraditórios, as vacas com deficiência de energia no início da amamentação têm diminuição nas concentrações de hormona luteinizante (LH), isto conclui que a alteração ovárica seria determinada por uma alteração da liberação pulsátil de LH devido a uma deficiência energética aguda. A intensidade e a duração do estro são de importância fundamental para a IA nos bovinos. Ao ocorrer uma deficiência de sódio, aumenta-se a estabilização das membranas celulares impedindo que o corpo lúteo se lise, formando-se um cisto, que continuará com a produção de progesterona, levando, por fim, a um anestro patológico. O sódio é um elemento que deve estar disponível aos animais de forma à vontade, ou seja, esse mineral é combinado com o Cl, fazendo o balanceamento eletrolítico e disponibilizado para os animais pelo conhecido sal. Sua administração, como é em sistema à vontade, não é muito controlada, mas o produtor poderá fornecer as quantidades na mistura alimentar do animal, tendo um maior controle da absorção do mesmo pelos animais. Sendo assim, o Na deve ser fornecido em quantidades que obedeçam 0,10 a 0,18% da MS no caso das forrageiras, ou a mesma quantidade misturada no todo da ração, quantidade essa encontrada por meios de cálculos, ou que já vêm na composição da ração industrial. Estudos apontam que um animal deve ingerir cerca de 50 gramas de NaCl por dia, no caso do sódio estar presente em 39% da composição desse cloreto de sódio. REFERÊNCIAS BIBLIOGRÁFICAS BARRENHO, Gonçalo José Pinheiro. Nutrição e fertilidade em bovinos de leite. 2016. Dissertação de Mestrado. Universidade de Évora. BINDARI, Yugal Raj et al. Effects of nutrition on reproduction-A review. Adv. Appl. Sci. Res, v. 4, n. 1, p. 421-429, 2013. BOLAND, M. P. Efectos nutricionales en la reproducción del ganado. XXXI Jornadas Uruguayas de Buiatría, 2003. CHAMBA OCHOA, Hermógenes René; BENÍTEZ GONZÁLEZ, Edgar Enrique; PESÁNTEZ CAMPOVERDE, Manuel Teodoro. Factores predisponentes para la enfermedad quística ovárica bovina y su efecto en la eficiencia reproductiva. Revista de Medicina Veterinaria, v. 1, n. 35, p. 17-28, 2017. DEHNING, R. Interrelaciones entre nutrición y fertilidad. In: Curso Manejo de la Fertilidad Bovina18-23 May 1987Medellín (Colombia). CICADEP, Bogotá (Colombia) Universidad de La Salle, Medellín (Colombia) Instituto Colombiano Agropecurio, Bogotá (Colombia) Sociedad Alemana de Cooperación Técnica-GTZ (Alemania), 1987. DE LUCA, Leonardo J. Nutrición y fertilidad en el ganado lechero. XXXVI Jornadas Uruguayas de Buiatría, 2008. DIAS, Juliano Cesar et al. Alguns aspectos da interação nutrição-reprodução em bovinos: energia, proteína, minerais e vitaminas. PUBVET, v. 4, p. Art. 738-743, 2010. FERNANDES, C. A. C. et al. Fatores predisponentes para cistos ovarianos em vacas da raça holandesa. Ars Veterinaria, v. 21, n. 2, p. 287-296, 2008. GORDON, Ian. Controlled reproduction in farm animals series. Nova Iorque: CAB International, 1996. HATLER, T. B. et al. Effect of a single injection of progesterone on ovarian follicular cysts in lactating dairy cows. The Veterinary Journal, v. 172, n. 2, p. 329-333, 2006. KESLER, D. J.; GARVERICK, H. A. Ovarian cysts in dairy cattle: a review. Journal of animal science, v. 55, n. 5, p. 1147-1159, 1982. MAAS, John. Relationship between nutrition and reproduction in beef cattle. The Veterinary Clinics of North America. Food Animal Practice, v. 3, n. 3, p. 633-646, 1987. MENDOZA, R. Muñoz et al. Parámetros reproductivos en vacas Holstein alimentadas con alfalfa alta en cumestrol. Archivos de zootecnia, v. 51, n. 195, p. 373-376, 2002. PASA, Camila. Relação reprodução animal e os minerais. Biodiversidade, v. 9, n. 1, 2011. SARTORI, Roberto; GUARDIEIRO, Monique Mendes. Fatores nutricionais associados à reprodução da fêmea bovina. Revista Brasileira de Zootecnia, v. 39, p. 422-432, 2010. SHORT, Robert E.; ADAMS, D. C. Nutritional and hormonal interrelationships in beef cattle reproduction. Canadian Journal of Animal Science, v. 68, n. 1, p. 29-39, 1988. THATCHER, W. W. et al. Strategies for improving fertility in the modern dairy cow. Theriogenology, v. 65, n. 1, p. 30-44, 2006. TEIXEIRA, J. C.; TEIXEIRA, LFAC. Alimentação de bovinos leiteiros. FAEPE, Lavras, 1997. YOSHIOKA, Koji; IWAMURA, Shokichi; KAMOMAE, Hideo. Changes of ovarian structures, plasma LH, FSH, progesterone and estradiol-17β in a cow with ovarian cysts showing spontaneous recovery and relapse. Journal of veterinary medical science, v. 60, n. 2, p. 257-260, 1998. (shrink)

This article aims to analyze some aspects of the work Manual para a Vida Feliz, the result of classes given by Epictetus, and recorded by his student Ariano. We will consider the situations that, according to Epictetus, depend on the individual and those that do not depend on their action. In particular, this analysis will focus on fragments 1 to 6 of the manual, given the length to be analyzed in an article. To account for the proposed object, this analysis (...) will be carried out, based on Hadot's (2015) perspective on the subject. The research method used will be bibliographic review. As for the methodology, it will be deductive in nature. Our studies show that his teachings are based on the essential principles of Stoic philosophy. Therefore, the only good that exists, for him, is the moral good. Furthermore, all human action is based on judgment and nature is coherent with itself. From this perspective, what depends on the individual, in this life, is what is under their control and everything that is beyond their control does not depend on them. Therefore, worrying about what is not under your control is considered useless and a waste of time. (shrink)

This article aims to elucidate, albeit in a preliminary way, the concept of liquidity in Zygmunt Bauman and its effects onsociety. The deductive-inductive method will be used. As for the methodology, this will be of a bibliographic nature. This study is in line with what the sociologist Zygmunt Bauman (1925-2017), in his texts, postulates that Modernity can be divided into two phases: Solid Modernity and Liquid Modernity. The first began in the 15th century and lasted until the 19th century; the (...) second began in the 20th century and continues to the present time. To describe modern society from the end of the 20th century, Bauman uses the metaphor of 'liquidity', aiming to point out that the contemporary world is going through a period of uncertainty, ephemerality and instabilities. According to Bauman, the modern ideal coined between the 15th and 19th centuries postulated the primacy of reason and the autonomy of capitalist man and such assumptions led society to liquid modernity. In this liquid “contemporaneity”, nothing is lasting, everything is volatile, ephemeral; consumption is the social parameter, whether of the individual, the family, the State or religion. (shrink)

Political theorists have recently sought to replace the liberal, contractual theory of the firm with a political view that models the authority relation of employee to firm, and its appropriate regulation, on that of subject to state. This view is liable to serious difficulties, however, given existing discontinuities between corporate and civil authority as to their coerciveness, entry and exit conditions, scope, legal standing, and efficiency constraints. I here inspect these, and argue that, albeit in some cases significant, such discontinuities (...) fail to undermine the firm/state analogy, either because they are not significant enough to do so or because the particular trait on which they hinge is not decisive for how authority, in the state and in the firm, should be regulated to be legitimate. A pro tanto requirement exists, I thus argue, that corporate authority be held to regulatory norms comparable to those legitimate states abide by, including civil liberties, rule-of-law constraints, and accountability to subjects. (shrink)

This article aims to present the understanding of spiritual exercises in Pierre Hadot and its importance. In order to give an account of the proposed object we will resort to bibliographical and documentary research. In the present work, we emphasize that the definition of spiritual exercises is complex, as the author himself says. According to Hadot (2014), this term arose with the ancient Greeks, and not with Christianity and is linked to the practice of caring for oneself. According to him, (...) the Stoics already had the habit of turning to themselves and reflecting their own existence through exercises. In his quest to give a definition for the expression 'Spiritual Exercises', Hadot (2014) in his writings presents some reasons why he chose the term. According to him, reading the collection A Poetry as a spiritual exercise, as well as the contact with the work of Élisabeth Brisson, and with the book of Paul Rabbow [Seelenführung. Methodik der Exerzitien in der Antike], led him to understand the depth of the expression 'Spiritual Exercise', although this does not express the density of reality experienced in the experience of encounter with oneself and with the world. (shrink)

This study aims to deepen the philosophical aspects of the relationship between the work of Pierre Hadot and Michel Foucault, with regard to the concepts of "Spiritual Exercises" and "Self-Care". We intend to analyze how Pierre Hadot interpreted the appropriation that Michel de Foucault made of his text "spiritual exercises", when presenting the notion about the definition of "Care of the self". We elucidate the main divergences and convergences present between the philosophical reflections of these two authors, which are of (...) great relevance for the understanding of current phenomena. The methodology adopted was exploratory theoretical-bibliographic research, halfway betweena comment and an essay. Our studies point to the theme of 'the self' as the central point of the research, with “Self-Care” as the bias capable of leading us to knowledge and, in this way, taking us to the direction of existence through the rationality ofthe “Exercises” Spiritual ”. Our two authors, in their discussions about “taking care of oneself”, evoke in part the thinking of the Greeks, who are the source of the definition of this principle. Therefore, the term “epimeleia heauton” will guide us, that is, to undertake in the face of the world of life, in the practice of thorough and permanent criticism in the face of one's own conduct. In other words, by means of these spiritual exercises, thus being able to contemplate oneself rationally on a path towards "oneself" and through "oneself". Furthermore, all of this implies a constant effort on the will and desire, in order to architect authentic autonomy on a daily basis. We do not intend to exhaust the whole subject, however, the relationship to be developed will bring us closer to dominance over ourselves and make us reflect on the state of "having oneself in the hands.". (shrink)

This paper aims to contribute to the existing literature on normative cognition by providing a lineage explanation of human social norm psychology. This approach builds upon theories of goal-directed behavioral control in the reinforcement learning and control literature, arguing that this form of control defines an important class of intentional normative mental states that are instrumental in nature. I defend the view that great ape capacities for instrumental reasoning and our capacity (or family of capacities) for shared intentionality coadapted to (...) each other and argue that the evolution of this capacity has allowed the representation of social norms and the emergence of our capacity for normative guidance. (shrink)

Our goal in this paper is to articulate a precise concept of at least a certain kind of disease-mongering, showing how pharmaceutical marketing can commercially exploit certain diseases when their best definition is given through the success of a treatment in a clinical trial. We distinguish two types of disease-mongering according to the way they exploit the definition of the trial population for marketing purposes. We argue that behind these two forms of disease-mongering there are two well-known problems in the (...) statistical methodology of clinical trials (the reference class problem and the distinction between statistical and clinical significance). Overcoming them is far from simple. (shrink)

This paper argues that racism should not only be conceived as a moral concept whose main aim is to condemn severe wrongs in the domain of race. The paper advances a complementary interpretation of racism as an explanatory concept--one that plays a key role in explaining race-based social problems afflicting members of subordinate racialized groups. As an explanatory concept, the term 'racism' is used to diagnose and highlight the causes of race-related social problems. The project of diagnosing race-based social problems (...) contributes to the pragmatic anti-racist end of developing better political and policy strategies for solving these social problems. The paper defends this interpretation of racism as an explanatory concept through a critical engagement with Urquidez's moral-philosophical account of racism. (shrink)

In times of climate change and public debt, a concern for intergenerational justice should lead us to have a closer look at theories of intergenerational justice. It should also press us to provide institutional design proposals to change the decision-making world that surrounds us. This book provides an exhaustive overview of the most important institutional proposals as well as a systematic and theoretical discussion of their respective features and advantages. It focuses on institutional proposals aimed at taking the interests of (...) future generations more seriously, and does so from the perspective of applied political philosophy, being explicit about the underlying normative choices and the latest developments in the social sciences. It provides citizens, activists, firms, charities, public authorities, policy-analysts, students, and academics with the body of knowledge necessary to understand what our institutional options are and what they entail if we are concerned about today's excessive short-termism. (shrink)

I defend impact-based accounts of institutional racism against the criticism that they are over-inclusive. If having a negative impact on non-whites suffices to make an institution racist, too many institutions (including institutions whose affirmative action policies inadvertently harm its intended beneficiaries) would count as racist. To address this challenge, I consider a further necessary condition for these institutions to count as racist—they must stand in a particular relation to racist ideology. I argue that, on the impact-based model, institutions are racist (...) if they have a negative racial impact AND this impact is legitimized by racist ideology. Racist ideologies limit social criticism of and collective action against institutions that have a negative racial impact, and in so doing, lend stability to systems of racial domination. (shrink)

Self-employment merits protection and promotion, we often hear, because it confers independence from a boss. But what, if anything, is wrong with having a boss? On one of the two views that this chapter inspects, being under the power of a boss is objectionable as such, no matter how suitably checked this power may be, for it undermines workers’ agency. On a second view, which republican theorists favor, what is objectionable is subjection not to the power of a boss as (...) such but to their arbitrary power. The first view is unconvincing, I argue, as it entails (implausibly) that being under the power of others in realms like the family or the state is likewise objectionable as such. And although the second view yields compelling reasons for self-employment, it only does so when employers’ power is not suitably checked. When it is, such reasons are more easily outweighed by competing considerations, like those stemming from the further forms of dependence—on suppliers and purchasers—that self-employment may prompt. (shrink)

Workplace democracy is often defined, and has recently been defended, as a form of intra-firm governance in which workers have control rights over management with no ownership requirement on their part. Using the normative tools of republican political theory, the paper examines bargaining power disparities and moral hazard problems resulting from the allocation of control rights and ownership to different groups within democratic firms, with a particular reference to the European codetermination system. With various qualifications related to potentially mitigating factors, (...) such as workforce and shareholder composition or risk aversion and reallocation, the paper contends that forms of workplace democracy in which workers control and own the firm, such as cooperativism, are preferable to other forms, such as codetermination, in which ownership and control rights are formally separated. (shrink)

Workplace democracy is often advocated on two intertwined views. The first is that the authority relation of employee to firm is akin to that of subject to state, such that reasons favoring democracy in the state may likewise apply to the firm. The second is that, when democratic controls are absent in the workplace, employees are liable to objectionable forms of subordination by their bosses, who may then issue arbitrary directives on matters ranging from pay to the allocation of overtime (...) and to relocation and promotion. Daniel Jacob and Christian Neuhäuser have recently submitted these views to careful criticism. They argue that the parallel between firms and states is unwarranted. For, unlike managerial authority, state authority is final. The state grants firms their legal status and subjects their authority to its regulations, which citizens in democracies already control. And they also argue that suitable workplace regulation alongside meaningful exit options may suffice to prevent, with no need for democratization, objectionable forms of workplace subjection. Neither view offers, they resolve, compelling reasons to believe that justice requires that firms be democratic. I here inspect these criticisms in turn, and offer reasons for skepticism. (shrink)

This study presents and develops in detail (a new version of) the argumental conception of meaning. The two basic principles of the argumental conception of meaning are: i) To know (implicitly) the sense of a word is to know (implicitly) all the argumentation rules concerning that word; ii) To know the sense of a sentence is to know the syntactic structure of that sentence and to know the senses of the words occurring in it. The sense of a sentence is (...) called immediate argumental role of that sentence. According to the argumental conception of meaning a theory of meaning for a particular language yields a systematic specification of the understanding of every sentence of the language which consists in a specification of the immediate argumental role of the sentence. The immediate argumental role is a particular aspect of the use of a sentence in arguments. But it is not the whole use in arguments, nor is the whole use in arguments reducible to the immediate argumental role. That is why, by accepting the argumental conception of meaning, we can have epistemological holism without linguistic holism. The argumental conception distinguishes between the understanding and the correctness of a language. Such a distinction makes it possible to account for our understanding of paradoxical languages. Redundancy theory of truth, realistic conceptions of truth or epistemic conceptions of truth are all compatible with an argumental conception of sense. But here it is argued that an epistemic conception of truth is preferrable. Acceptance of the argumental conception of meaning and of an epistemic conception of truth leads to a rejection of the idea of analytic truth. The argumental conception is pluralistic with respect to the understandability of different logics, and neutral with respect to their correctness. (shrink)

Despite renewed interest in work, philosophers have largely ignored self-employment. This neglect is surprising, not just because self-employment was central to classic philosophizing about work, but also given that half of the global workforce today, including one in seven workers in OECD countries, are self-employed. We start off by offering a definition of self-employment, one that accounts for its various forms while avoiding misclassifying dependent self-employed workers as independent contractors, and by mapping the barriers to becoming and remaining self-employed (section (...) 2). We then examine five arguments why governments ought to promote self-employment, despite the forgone opportunities to promote employee work instead that this often entails (sections 3-7): the argument from job creation, the argument from job satisfaction, the argument from independence, the argument from occupational freedom, and the argument from subsistence under non-ideal circumstances. Some of these are unconvincing, we argue, but others are not. Although the strength of the latter arguments hangs on various context-dependent conditions, such that they need to be carefully weighed against considerations of efficiency and equality, they nonetheless offer compelling pro tanto reasons to promote, and not just to protect, self-employment. (shrink)

Higher‐order evidence can make an agent doubt the reliability of her reasoning. When this happens, it seems rational for the agent to adopt a cautious attitude towards her original conclusion, even in cases where the higher‐order evidence is misleading and the agent's original reasons were actually perfectly good. One may think that recoiling to a cautious attitude in the face of misleading self‐doubt involves a failure to properly respond to one's reasons. My aim is to show that this is not (...) so. My proposal is that (misleading) higher‐order evidence can undermine the agent's possession of her first‐order reasons, constituting what I call a dispossessing defeater. After acquiring the higher‐order evidence, the agent is no longer in a position to rely competently on the relevant first‐order considerations as reasons for her original conclusion, so that such reasons stop being available to her (even if they remain as strong as in the absence of the higher‐order evidence). In this way, an agent with misleading higher‐order evidence can adopt a cautious stance towards her original conclusion, while properly responding to the set of reasons that she possesses–a set that is reduced due to the acquisition of higher‐order dispossessing defeaters. (shrink)

It is widely held that there is a distinctive norm of assertion. A plausible idea is that there is an analogous, perhaps weaker, norm for indirect communication via implicatures. I argue against this type of proposal. My claim is that the norm of assertion is a social norm governing public updates to the conversational record. Off the record implicatures are not subject to social norms of this type. I grant that, as happens in general with intentional actions, off the record (...) communicative acts may be subject to normative assessments on different levels (for instance, regarding their moral or prudential appropriateness). However, such assessments do not generate distinctive norms that apply to all cases of implicature. (shrink)

The paradox of persisting opposition raises a puzzle for normative accounts of democratic legitimacy. It involves an outvoted democrat who opposes a given policy while supporting it. The article makes a threefold contribution to the existing literature. First, it considers pure proceduralist and pure instrumentalist alternatives to solve the paradox and finds them wanting — on normative, conceptual, and empirical grounds. Second, it presents a solution based on a two-level distinction between substantive and procedural legitimacy that shows that citizens are (...) consistent in endorsing the upshot of democratic procedures while opposing it. Third, it unpacks three reasons to non-instrumentally endorse such procedures — namely, the presence of reasonable disagreement, non-paternalism, and the right to democratically do wrong. In so doing, the article shows that those accounts of democratic legitimacy that rely on reasonable disagreement as a necessary condition for democratic procedures being called for are flawed, or at least incomplete, and offers a more complete alternative. (shrink)

I address the objection that the concept of racism has become overly inflated. Critics of the conceptual inflation of “racism” argue that theories of institutional racism engage in untoward conceptual inflation insofar as they undermine our moral understanding of racial phenomena, hinder our ability to explain the causes of racial inequality, and even undercut struggles for racial justice. I develop an original account of institutional racism and show that it is immune to all three versions of the conceptual inflation challenge.

The author presents a theory of meaning centred upon the notion of "immediate argumental role", which distinguishes between understandability and correctness of a language. First, the theoretical and quasi-empirical criteria of adequacy and the relevant data for such a theory are described. Then the sense of a word is defined as given by a set of argumentation rules. The immediate argumental role of a sentence is determined by its syntactic structure and by the senses of the component words. The immediate (...) argumental role of a sentence is distinguished from its global argumental role. Different conceptions of truth are compatible with the resulting theory of sense, but the author gives some reasons for preferring an epistemic conception of truth. The possibility of understandable and meaningful paradoxical languages and of many different understandable logics is a consequence of such a view. (shrink)

There are various proposals for a general characterization of holism1. In this paper I propose the following: a variety of holism is the view that every X of an appropriate kind, which is part of a relevant whole W, cannot be legitimately separated or taken in isolation from W. Then, I distinguish two general kinds of holism, depending on two different reasons which can debar us from taking X in isolation from W. One reason can be that separating X from (...) W always amounts to transforming X into something else. Correspondingly, a strong holism is the view that if the whole W is modified anywhere, X ceases to be X and becomes something else. Another reason why it may be illegitimate to consider X in isolation from W can be that if we separate X from W, nothing that we know entitles us to exclude that X might be transformed into something else. Correspondingly, virtual holism is the view that if the whole W is modified anywhere, we can never rule out that X ceases to be X and becomes something else. (shrink)

We discuss the role of practical costs in the epistemic justification of a novice choosing expert advice, taking as a case study the choice of an expert statistician by a lay politician. First, we refine Goldman’s criteria for the assessment of this choice, showing how the costs of not being impartial impinge on the epistemic justification of the different actors involved in the choice. Then, drawing on two case studies, we discuss in which institutional setting the costs of partiality can (...) play an epistemic role. This way we intend to show how the sociological explanation of the choice of experts can incorporate its epistemic justification. (shrink)

En aras del universalismo y en contra del totalitarismo, la ética discursiva ha mostrado con Jürgen Habermas un déficit práctico al negar a la filosofía moral la posibilidad de reflexionar sobre las condiciones alienantes del diálogo desde un ethos concreto. Este artículo analiza el modo en que la teoría de la resonancia formulada por Hartmut Rosa permite revitalizar el debate sobre las condiciones que pueden minar las bases para el diálogo en las sociedades aceleradas sin apoyarse en el concepto de (...) ethos, sino en el de modo de relacionarse con el mundo [Modus der Weltbeziehung]. (shrink)

This paper examines the link between political liberties and social equality, and contends that the former are constitutive of, i.e. necessary to secure, the latter. Although this constitutive link is often assumed in the literature on political liberties, the reasons why it holds true remain largely unexplored. Three such reasons are examined here. First, political liberties are constitutive of social equality because they bestow political power on their holders, leaving disenfranchised individuals excluded from decisions that are particularly pervasive, coercively enforced, (...) hard to avoid, monopolistic, and final. Second, they are constitutive of social equality due to their positional value, such that those who are denied such liberties are socially downgraded because and to the extent that others enjoy them. Third, they are constitutive of social equality due to their expressive value, in the sense that, by disenfranchising some individuals, the state publicly fails to recognize their equal moral agency. While unpacking these reasons, we address some criticisms of this constitutive link recently raised by Steven Wall and Jason Brennan. (shrink)

En este artículo argumento que, pese al llamado “escepticismo cartesiano”, el significado y alcance de la refutación cartesiana del escéptico y del ateo pueden comprenderse a la luz de tres hitos metafísicos. En la primera sección examino de qué forma este filósofo emplea argumentos escépticos como método, no como fin. Tal como enfatizo, el cogito es el punto en que la duda hiperbólica debe detenerse. Luego, en la segunda sección, discuto por qué Descartes es contrario al fideísmo. Debido a que (...) este se relaciona con el escepticismo, y con la imposibilidad de probar la existencia de Dios, Descartes prueba que Él existe. Sostengo, en la sección final, que Dios es garante de la certeza epistemológica, incluso en el caso de las ideas claras y distintas, cuya confiabilidad pareciera en peligro debido a la hipótesis escéptica del genio maligno. Según el francés, entonces, probar que Dios existe es necesario para garantizar el conocimiento cierto, y es base para inferir la existencia del mundo externo. Los tres hitos, entonces, parecen suficientes para delimitar el sentido y alcance del llamado escepticismo cartesiano. (shrink)

Institutions to address short-termism in public policymaking and to more suitably discharge our duties toward future generations have elicited much recent normative research, which this chapter surveys. It focuses on two prominent institutions: insulating devices, which seek to mitigate short-termist electoral pressures by transferring authority away to independent bodies, and constraining devices, which seek to bind elected officials to intergenerationally fair rules from which deviation is costly. The chapter first discusses sufficientarian, egalitarian, and prioritarian theories of our duties toward future (...) generations, and how an excessive focus on the short term in policymaking may hinder that such duties be fulfilled. It then surveys constraining and insulating devices, and inspects their effectiveness to address the epistemic, motivational, and institutional drivers of political short-termism as well as their intra- and intergenerational legitimacy. (shrink)

Several European countries are approving legislative reforms moving to a presumed consent system in order to increase organ donation rates. Nevertheless, irrespective of the consent system in force, family's decisional capacity probably causes a greater impact on such rates. In this contribution we have developed a systematic methodology in order to analyse and compare European organ procurement laws, and we clarify the weight given by each European law to relatives' decisional capacity over individual's preferences (expressed or not while alive) regarding (...) the destination of his or her organs after death. In this sense, the results constitute the first comprehensive and comparative legislative mapping on European transplantation laws. (shrink)

Representing unborn generations to more suitably include future interests in today's climate policymaking has sparked much interest in recent years. In this review we survey the main proposed instruments to achieve this effect, some of which have been attempted in polities such as Israel, Philippines, Wales, Finland, and Chile. We first review recent normative work on the idea of representing future people in climate governance: The grounds on which it has been advocated, and the main difficulties that traditional forms of (...) representation have encountered when applied to this particular case. We then survey existing institutional means to represent generations to come. We separate out representation in courts, in parliament, and by independent bodies, and review specific instruments including climate litigation, parliamentary commissions, future representatives, youth quotas, and independent offices for future generations. We examine the particular forms whereby each of these may suitably represent future people, including audience representation, surrogate representation, and indicative representation, and discuss the main challenges they encounter in so doing. (shrink)

Alberto Coffa used the phrase "the Copernican turn in semantics" to denote a revolutionary transformation of philosophical views about the connection between the meanings of words and the acceptability of sentences and arguments containing those words. According to the new conception resulting from the Copernican turn, here called "the Copernican view", rules of use are constitutive of the meanings of words. This view has been linked with two doctrines: (A) the instances of meaning-constitutive rules are analytically and a priori true (...) or valid; (B) to grasp a meaning is to accept its rules. The pros and cons of different versions of the Copernican view, ascribable to Wittgenstein, Carnap, Gentzen, Dummett, Prawitz, Boghossian and other authors, will be weighed. A new version will be proposed, which implies neither (A) nor (B). (shrink)

El objetivo de este artículo es el de señalar las implicaciones del concepto de deporte a través del materialismo filosófico de Gustavo Bueno en su obra Ensayo de una definición filosófica de la Idea de Deporte. Desde esta perspectiva, Bueno llega a la conclusión de que no hay una idea unívoca de deporte, sino que nos encontramos ante un concepto sobre el que se han depositado diversas acepciones según el objetivo físico, político, social o religioso atribuido al deporte. Esta diversidad (...) conceptual habilita al docente de Educación Física a utilizar el deporte como un medio pedagógico encajándolo de diferentes formas en su planificación. La principal conclusión es que el deporte puede ser utilizado no solo desde la perspectiva centrada en la práctica del deporte en sí, con sus reglas y movimientos, o teniendo solo como objetivo la actividad física, sino que puede utilizarse con relación a otros ámbitos de la educación física como la expresión corporal o los deportes populares. Con relación al estado de Ecuador, el currículum de Educación Física genera espacios para pensar en la Educación Física desde la interdisciplinariedad de sus ámbitos y no solo desde lo estrictamente deportivo. (shrink)

Niccolò Machiavelli's support for what he calls governo largo, or popular government, is usually contrasted with the diffidence towards it of Francesco Guicciardini, the Florentine aristocrat. The article argues that both these authors grounded their vision on Polybius' theory of “mixed government,” though adapting it in different directions. In examining this difference, the article reaches the conclusion that it concerns far less the degree of popular participation in political decision-making and government than the value that Machiavelli and Guicciardini respectively ascribe (...) to it in comparison with that of safety-liberty. In this respect, their theories may be viewed as anticipating the tensions between democracy and the rule of law, the co-presence of which provides the essential foundation of the structure of present-day constitutional democracies. (shrink)

Two ideas of Jean-Luc Nancy stand out: the subject as a plurality of possibilities open to the world in a constant event and the importance of the body in understanding the subject’s situation in the world. These ideas are drawn from the works of Jean-Luc Nancy A subject? And Corpus. First, the main ideas of A Subject? And secondly, those of Corpus. In a final section, the main conclusions of these two ideas are drawn, among which stand out the importance (...) of understanding the subject as a plurality open to the becoming of the world and the importance of the body as the entity that experiences, thinks, and lives reality without intermediaries. (shrink)

Can an epistemic conception of truth and an endorsement of the excluded middle (together with other principles of classical logic abandoned by the intuitionists) cohabit in a plausible philosophical view? In PART I I describe the general problem concerning the relation between the epistemic conception of truth and the principle of excluded middle. In PART II I give a historical overview of different attitudes regarding the problem. In PART III I sketch a possible holistic solution.

What is an inference? Logicians and philosophers have proposed various conceptions of inference. I shall first highlight seven features that contribute to distinguish these conceptions. I shall then compare three conceptions to see which of them best explains the special force that compels us to accept the conclusion of an inference, if we accept its premises.