In the contemporary biomedical literature, every disease is considered genetic. This extension of the concept of genetic disease is usually interpreted either in a trivial or genocentrist sense, but it is never taken seriously as the expression of a genetic theory of disease. However, a group of French researchers defend the idea of a genetic theory of infectious diseases. By identifying four common genetic mechanisms (Mendelian predisposition to multiple infections, Mendelian predisposition to one infection, and major (...) gene and polygenic predispositions), they attempt to unify infectious diseases from a genetic point of view. In this article, I analyze this explicit example of a genetic theory, which relies on mechanisms and is applied only to a specific category of diseases, what we call “a regional genetic theory.” I have three aims: to prove that a genetic theory of disease can be devoid of genocentrism, to consider the possibility of a genetic theory applied to every disease, and to introduce two hypotheses about the form that such a genetic theory could take by distinguishing between a genetic theory of diseases and a genetic theory of Disease. Finally, I suggest that network medicine could be an interesting framework for a genetic theory of Disease. (shrink)

Response to commentary. We are grateful to Crockett and Craigie for their interesting remarks on our paper. We accept Crockett’s claim that there is a need for caution in drawing inferences about patient groups from work on healthy volunteers in the laboratory. However, we believe that the evidence we cited established a strong presumption that many of the patients who are routinely taking a medication, including many people properly prescribed the medication for a medical condition, have morally significant aspects of (...) their cognition and behavior modified in a way that is unintended and may sometimes be unwelcome. Crockett notes that in some cases the effects of long-term drug use may differ, sometimes markedly, from the effects of short-term use. However, if acute use of a drug affects a neural system involved in mediating moral cognition or behavior, this nevertheless provides some evidence that chronic use of the drug may affect that same system and thus have morally significant effects. It is also plausible, in some cases, that an acute moral effect would give rise to a chronic moral effect via cognitive mechanisms. ... (shrink)

Whipple disease is a rare, infectious, disease first described from a single case by Whipple in 1907. As well as characterising the clinical and pathological features of the condition, Whipple made two suggestions regarding its aetiology. These were either than the disease was caused by an infectious agent, or that it was of metabolic origin. As the disease is now thought to be caused by infection with the bacterium Tropheryma whipplei, historical reviews of the history of (...) the disease typically mention only the first of these suggestions. In this paper, we therefore revisit Whipple’s other theory. We argue that a diverse and often successful research programme was developed around this mechanism of disease causation which gave rise to many useful findings on the condition. In the later parts of this article, we then turn to discuss the surprising neglect of this period of Whipple disease research in the current literature, and conclude by offering a brief reconstruction of this early history suitable for use in a technical context. (shrink)

Current COVID-19 pandemic and previous SARS/MERS outbreaks have caused a series of major crises to global public health. We must integrate the large and exponentially growing amount of heterogeneous coronavirus data to better understand coronaviruses and associated disease mechanisms, in the interest of developing effective and safe vaccines and drugs. Ontologies have emerged to play an important role in standard knowledge and data representation, integration, sharing, and analysis. We have initiated the development of the community-based Coronavirus Infectious (...) class='Hi'>Disease Ontology (CIDO). As an Open Biomedical Ontology (OBO) library ontology, CIDO is an open source and interoperable with other existing OBO ontologies. In this article, the general architecture and the design patterns of the CIDO are introduced, CIDO representation of coronaviruses, phenotypes, anti-coronavirus drugs and medical devices (e.g. ventilators) are illustrated, and an application of CIDO implemented to identify repurposable drug candidates for effective and safe COVID-19 treatment is presented. (shrink)

In this article I contrast 17th and 18th explanations of hysteria including those of Sydenham and Willis with those given by Plato and pre-modern medicine. I show that beginning in the second decade of the 17th century the locus of the disorder was transferred to the nervous system and it was no longer connected with the womb as in Hippocrates and Galen; hysteria became identified with hypochondria, and was a disease contracted by men as well as women. I discuss (...) the purely mechanical explanation of hysteria given by Robert Boyle who attributed its cause to corporeal ideas as well as overly sensitive disposition of the nervous system. I relate this the mechanical theory of the nervous system prominent in Descartes' writings on physiology. The paper closes with a discussion of the contrast between early modern explanations of hysteria and the nature of man with those of Freud in the early 20th century. (shrink)

As urbanization accelerates, diminishing green spaces pose growing public health challenges, exacerbating pollution exposure, stress, and chronic illnesses. This narrative review synthesizes research on the biological and psychological pathways through which urban plants promote human health. Biologically, urban greenery enhances air quality by filtering pollutants, strengthens immune function by increasing microbial diversity, and regulates stress physiology via endocrine mechanisms. Psychologically, nature exposure restores cognitive function, reduces stress, and fosters emotional resilience, as evidenced by neuroimaging and epidemiological studies. The findings (...) suggest that integrating green infrastructure into urban environments yields measurable public health benefits, including lower mortality rates, reduced cardiovascular and respiratory disease prevalence, and improved mental well-being. However, critical research gaps remain regarding the optimal “doses” of nature for health, cultural differences in nature perception, and the potential role of incorporating insights from quantum and informational theories to study cognitive-environment interactions (e.g., Granular Interaction Thinking Theory). Addressing these gaps through interdisciplinary collaboration, artificial intelligence integration, and data-driven urban planning can help cities evolve into healthier, more sustainable ecosystems. (shrink)

This thesis examines philosophical controversies surrounding the evaluation of medical treatments, with a focus on the evidential roles of randomised trials and mechanisms in Evidence-Based Medicine. Current 'best practice' usually involves excluding non-randomised trial evidence from systematic reviews in cases where randomised trials are available for inclusion in the reviews. The first paper challenges this practice and evaluates whether adding of evidence from non-randomised trials might improve the quality and precision of some systematic reviews. The second paper compares the (...) alleged methodological benefits of randomised trials over observational studies for investigating treatment benefits. It suggests that claims about the superiority of well-conducted randomised controlled trials over well-conducted observational studies are justified, especially when results from the two methods are contradictory. The third paper argues that postulating the unpredictability paradox in systematic reviews when no detectable empirical differences can be found requires further justification. The fourth paper examines the problem of absence causation in the context of explaining causal mechanisms and argues that a recent solution (Barros 2013) is incomplete and requires further justification. Solving the problem by describing absences as causes of 'mechanism failure' fails to take into account the effects of absences that lead to vacillating levels of mechanism functionality (i.e. differences in effectiveness or efficiency). The fifth paper criticises literature that has emphasised functioning versus 'broken' or 'non-functioning' mechanisms emphasising that many diseases result from increased or decreased mechanism function, rather than complete loss of function. Mechanistic explanations must account for differences in the effectiveness of performed functions, yet current philosophical mechanistic explanations do not achieve this. The last paper argues that the standard of evidence embodied in the ICE theory of technological function (i.e. testimonial evidence and evidence of mechanisms) is too permissive for evaluating whether the proposed functions of medical technologies have been adequately assessed and correctly ascribed. It argues that high-quality evidence from clinical studies is necessary to justify functional ascriptions to health care technologies. (shrink)

Creativity and Intelligence: Emergent Properties of the Brain as a Balancing Mechanism for Overpopulation, Natural Disasters, and Diseases -/- The human brain is an extraordinary organ, capable of producing creativity and intelligence as emergent properties that allow humanity to address complex challenges. These traits are not merely tools for individual survival; they function as collective mechanisms to adapt to large-scale issues that threaten humanity’s balance with the environment. Overpopulation, natural disasters, and the prevalence of diseases and illnesses represent some (...) of the most significant pressures on human societies. Through the brain’s capacity for problem-solving and innovation, humanity has developed strategies to mitigate these challenges and maintain equilibrium within the universal law of balance. -/- The Brain as a Balancing Mechanism -/- At its essence, the brain operates as a dynamic system that processes external stimuli and generates adaptive responses. Creativity and intelligence arise from this system as tools to predict, analyze, and address challenges that disrupt balance. Overpopulation, natural disasters, and diseases disrupt human life on social, economic, and environmental levels, testing the brain’s ability to create solutions. -/- Creativity in Addressing Overpopulation -/- Overpopulation places immense strain on resources, ecosystems, and social structures, often leading to food shortages, environmental degradation, and urban overcrowding. The brain’s creative capacity has allowed humans to develop innovations to address these issues. Urban agriculture, such as vertical farming, is an example of how creativity has transformed food production in densely populated areas, reducing dependence on traditional farmland and conserving resources. Similarly, advancements in renewable energy technologies, such as solar and wind power, reduce the ecological footprint of growing populations, providing sustainable solutions to energy needs. -/- Creativity also plays a critical role in social policies and education. Family planning programs and reproductive health education have empowered individuals, particularly women, to make informed decisions, reducing population growth rates in many regions. These initiatives reflect the brain’s ability to create holistic solutions that align societal needs with the preservation of natural balance. -/- Intelligence in Managing Natural Disasters -/- Natural disasters, unpredictable and often catastrophic, require intelligent strategies to mitigate their impact. Intelligence enables humans to analyze data, predict disasters, and prepare for their consequences. Early warning systems for tsunamis, hurricanes, and earthquakes exemplify this, providing communities with critical time to evacuate and take protective measures. -/- Furthermore, intelligence drives the design of resilient infrastructure that can withstand disasters. For instance, earthquake-resistant buildings and flood mitigation systems demonstrate the brain’s capacity to transform scientific knowledge into practical solutions. These innovations save lives, reduce economic losses, and facilitate faster recovery after disasters, ensuring that human societies maintain their balance despite nature’s unpredictability. -/- Creativity and Intelligence in Combating Diseases and Illnesses -/- Diseases and illnesses have long been among humanity’s greatest challenges, especially in the context of overpopulation, which facilitates the rapid spread of infectious diseases. The brain’s emergent properties of creativity and intelligence have been critical in combating these threats through advancements in medicine, public health, and technology. -/- The development of vaccines, antibiotics, and antiviral drugs highlights humanity’s creative response to disease. For example, the eradication of smallpox and the near-elimination of polio are milestones achieved through creative and intelligent applications of medical science. During the COVID-19 pandemic, intelligence and creativity led to the rapid development of vaccines using mRNA technology, showcasing the brain’s ability to adapt to new challenges at an unprecedented pace. -/- Public health strategies, such as sanitation systems, clean water initiatives, and disease surveillance networks, also reflect the brain’s ability to create systemic solutions. These measures have significantly reduced the burden of communicable diseases, particularly in densely populated areas. Moreover, advancements in artificial intelligence and biotechnology continue to enhance humanity’s ability to detect, prevent, and treat illnesses. -/- The Interplay of Creativity, Intelligence, and Feedback Mechanisms -/- Creativity and intelligence act as feedback mechanisms that enable humans to respond to disruptions while maintaining balance within the universal law of nature. Overpopulation, natural disasters, and diseases disrupt this balance, prompting the brain to generate solutions that restore harmony. -/- For instance, urban planning that incorporates green spaces and sustainable infrastructure addresses the environmental strain caused by overpopulation. Similarly, the integration of traditional knowledge with modern technologies enhances disaster resilience. In the context of diseases, the collaboration of global institutions and local communities reflects the brain’s capacity to balance innovation with cultural and social considerations. -/- Challenges and Ethical Considerations -/- While creativity and intelligence empower humanity to address these challenges, they also carry significant ethical responsibilities. Technological advancements must align with principles of sustainability and equity. For example, while vaccines have saved millions of lives, unequal access to these innovations highlights the need for ethical distribution systems. Similarly, urban development projects must prioritize environmental conservation and community well-being to avoid exacerbating existing imbalances. -/- Additionally, the misuse of intelligence and creativity—such as the development of biological weapons or unsustainable industrial practices—can worsen the effects of overpopulation, natural disasters, and diseases. Ensuring that human ingenuity aligns with the principles of balance and harmony is essential to avoid unintended consequences. -/- Conclusion -/- Creativity and intelligence are emergent properties of the human brain that have enabled humanity to adapt to and mitigate the negative effects of overpopulation, natural disasters, and diseases. These traits function as balancing mechanisms, allowing humans to innovate and maintain harmony within the framework of natural laws. However, the application of these capabilities must be guided by ethical considerations and a commitment to sustainability. By aligning human creativity and intelligence with the universal law of balance, humanity can navigate its most pressing challenges and build a more resilient and equitable future. -/- . (shrink)

Abstract: This article explores the medical theories of the Dutch philosopher and physician Henricus Regius (1598-1679), who sought to provide clearer notions of medicine than the traditional theories of Jean Fernel, Daniel Sennert and Vopiscus Plempius. To achieve this, Regius overtly built upon the natural philosophy of René Descartes, in particular his theories of mechanical physiology and the corpuscular nature of matter. First, I show that Regius envisaged a novel partitioning of medicine, intended to make it independent in exposition but (...) conceptually grounded in natural philosophy. This served his overall purpose of making medicine a ‘clearer’ discipline. To this end Regius detaches the general notion of physiology as the study of the human body (which pertains to natural philosophy) from a medical physiology that concerns only health. Secondly, I show that Regius’s notions of health, disease, temperament and medicaments were the product of a Cartesian interpretation of traditional concepts, which was influenced by Santorio Santorio’s project of practicing medicine without occult elements. As a consequence, Regius’s classification of these notions is largely traditional. In conclusion, I show that Regius’s method of investigation in the area of natural philosophy consisted of a problem-solving procedure based on sensorial ideas. This approach can be traced back to Descartes, but was grounded on a purely empirical theory of knowledge, by which he rejected Descartes’s metaphysics. Regius’s order of exposition in natural philosophy and medicine, on the other hand, proceeds by definitions and divisions, and omits proofs. The reasons why Regius adopted this order were: 1) his rejection of Descartes’s metaphysical interpreta-tion of physics, and 2) his wish to emphasize the conceptual clarity and continuity of natural philosophy and medicine. (shrink)

In the midst of a pandemic, what does it mean to see the Other as Other and not as a carrier of the virus? I argue that in seeking a Levinasian response to the pandemic, we must be mindful of the implications of the mechanisms of surveillance and control that, presented as ways to protect the Other, operate by controlling the Other and rendering our relation to the Other increasingly impersonal. Subjected to these mechanisms, the Other becomes a (...) dangerous entity that must be controlled, and the state that deploys them comes increasingly to mediate the relation between self and Other. The more we rely on such mechanisms for protection, the easier it becomes to regard the Other not as one who summons me to an infinite responsibility but as a vector of disease. Despite all the differences between Levinas’s and Foucault’s approaches, reading them in conversation shows that the control and surveillance of the population functions within a discourse that medicalizes and objectifies the Other in favor of the centralizing power that uses those technologies. In defiance of Levinas’s warning against imposing a narrative on the Other’s suffering, this discourse coopts that suffering as a justification for biopower. (shrink)

Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the (...) limits of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

Automatic detection of diseases and anatomical landmarks in medical images by the use of computers is important and considered a challenging process that could help medical diagnosis and reduce the cost and time of investigational procedures and refine health care systems all over the world. Recently, gastrointestinal (GI) tract disease diagnosis through endoscopic image classification is an active research area in the biomedical field. Several GI tract disease classification methods based on image processing and machine learning techniques have (...) been proposed by diverse research groups in the recent past. However, yet effective and comprehensive deep ensemble neural network-based classification model with high accuracy classification results is not available in the literature. In this thesis, we review ways and mechanisms to use deep learning techniques to research on multi-disease computer-aided detection about gastrointestinal and identify these images. We re-trained five state-of-the-art neural network architectures, VGG16, ResNet, MobileNet, Inception-v3, and Xception on the Kvasir dataset to classify eight categories that include an anatomical landmark (pylorus, z-line, cecum), a diseased state (esophagitis, ulcerative colitis, polyps), or a medical procedure (dyed lifted polyps, dyed resection margins) in the Gastrointestinal Tract. Our models have showed results with a promising accuracy which is a remarkable performance with respect to the state-of-the-art approaches. The resulting accuracies achieved using VGG, ResNet, MobileNet, Inception-v3, and Xception were 98.3%, 92.3%, 97.6%, 90% and 98.2%, respectively. As it appears, the most accurate result has been achieved when retraining VGG16 and Xception neural networks with accuracy reache to 98% due to its high performance on training on ImageNet dataset and internal structure that support classification problems. (shrink)

When the face-to-face engagement was suspended due to the Coronavirus Disease-19 (COVID-19) pandemic, it paved the way for the utilization of flexible learning in higher education and one of its forms is modular distance learning modality. The key purpose of this study is to discover the challenges and the coping mechanisms of the students of West Visayas State University-Himamaylan City Campus in the modular distance learning modality as well as to develop possible curriculum enhancement plan. These challenges and (...) coping mechanisms were gathered through the qualitative-phenomenological approach by conducting in-depth interviews with the nine participants who were selected using purposive sampling, specifically the criterion sampling method. Thematic analysis was used to analyze the data. The main challenges that emerged were the struggles to understand the modules, complications in managing time, obstacles in retrieving and submitting modules, enduring uncomfortable places to learn, and lacking the technology to support new normal education. To cope with the said challenges, the students are motivating themselves to survive, learning collaboratively, setting up schedules to manage time effectively, taking a break after stressful days, and likewise praying to conquer difficulties. Considering the result of the study, it is recommended for the university to review its learning continuity plan. The CHED may increase the number of beneficiaries for the TES to address the financial aspects of the students for them to focus with their studies. Thus, curriculum enhancement plan was developed to address the challenges and improve the learning experiences of the students. (shrink)

Ever since the advent of molecular biology in the 1970s, mechanical models have become the dogma in the field, where a "true" understanding of any subject is equated to a mechanistic description. This has been to the detriment of the biomedical sciences, where, barring some exceptions, notable new feats of understanding have arguably not been achieved in normal and disease biology, including neurodegenerative disease and cancer pathobiology. I argue for a "mechanism-plus-X" paradigm, where mainstay elements of mechanistic models (...) such as hierarchy and correlation are combined with nomological principles such as general operative rules and generative principles. Depending on the question at hand and the nature of the inquiry, X could range from proven physical laws to speculative biological generalizations, such as the notional principle of cellular synchrony. I argue that the "mechanism-plus-X" approach should ultimately aim to move biological inquiries out of the deadlock of oft-encountered mechanistic pitfalls and reposition biology to its former capacity of illuminating fundamental truths about the world. (shrink)

Coronavirus Disease-19 (COVID-19) pandemic greatly affected the education system and led West Visayas State University-Himamaylan City Campus to modular distance learning. The purpose of this study is to find out the challenges of elementary-pre-service teachers in the use of modular distance learning modality. It employed a qualitative-phenomenological approach deemed most applicable in discovering students' lived experiences in modular distance learning modality amidst the pandemic. The participants of the study were the ten (10) Bachelor of Elementary Education (BEEd) students on (...) the Campus. Two semi-structured interviews were conducted using an interview guide was used in this study. The trustworthiness of the data collected was established through triangulation and member checking. It was discovered that students have difficulty understanding the modules, trouble connecting to the internet, complications in managing time, obstacles in retrieving and submitting the modules, and endure uncomfortable learning places. Considering that face-to-face mode is slowly returning to normal, it is recommended that teachers teach students how to work collaboratively with their peers and manage their time efficiently. (shrink)

This paper investigates how reticulate evolution contributes to a better understanding of human sociocultural evolution in general, and community formation in particular. Reticulate evolution is evolution as it occurs by means of symbiosis, symbiogenesis, lateral gene transfer, infective heredity, and hybridization. From these mechanisms and processes, we mainly zoom in on symbiosis and we investigate how it underlies the rise of (1) human, plant, animal, and machine interactions typical of agriculture, animal husbandry, farming, and industrialization; (2) diet-microbiome relationships; and (...) (3) host-virome and other pathogen interactions that underlie human health and disease. We demonstrate that reticulate evolution necessitates an understanding of behavioral and cultural evolution at a community level, where reticulate causal processes underlie the rise of synergistic organizational traits. (shrink)

Abstract: Colon cancer is a prevalent and life-threatening disease, necessitating accurate and timely diagnosis for effective treatment and improved patient outcomes. This research paper presents the development of a knowledge-based system for diagnosing colon cancer using the CLIPS language. Knowledge-based systems offer the potential to assist healthcare professionals in making informed diagnoses by leveraging expert knowledge and reasoning mechanisms. The methodology involves acquiring and structuring medical knowledge specific to colon cancer, followed by the implementation of a knowledge- based (...) system using CLIPS. The system's design integrates relevant medical databases and employs advanced reasoning mechanisms to facilitate accurate diagnosis. Evaluation results demonstrate the system's effectiveness, with high accuracy and sensitivity rates compared to existing methods. The findings highlight the potential of knowledge-based systems in improving clinical practice and patient care. The research contributes to the growing field of medical informatics by demonstrating the feasibility and effectiveness of CLIPS-based knowledge systems for colon cancer diagnosis. Future research can focus on enhancing system performance and expanding its scope to encompass other types of cancer diagnoses. (shrink)

The social group named after the various discourses of individuals who define themselves as the champions of the men's rights movement on social media is called the “Manosphere” in the literature. “Oneitis”, a concept in the jargon of the manosphere, basically refers to a disease state used to represent situations in which a man invests excessive attention in a woman who is not equally interested in him. For the Red Pill movement, the most influential group in the manosphere, oneitis (...) is criticized as a pattern of behavior that should be avoided by men. Red Pill philosophy is also often associated with alt-right ideologies due to its anti-feminist and pragmatic views. Red Pill thought can therefore often be seen as contrasting with Woke Culture, a counter-cultural movement that advocates the constant practice of vigilance against political discourses that oppress certain social groups through structural mechanisms of oppression such as racism, anti-blackness, and anti-feminism. In this paper, I argue that the concept of oneitis, when suspended from its anti-feminist and commodifying contexts, can in fact be read as a critique of a conception of love that is deeply rooted in traditional gender roles that are often criticized from perspectives such as feminism or Woke Culture. When the liberation from oneitis is considered independently of the manosphere framework, it can be read as a critique of coercive social practices in terms of romantic relationships. (shrink)

Our philosophical understanding of mental illness is being shaped by neuroscience. However, it has the paradoxical effect of igniting two radically opposed groups of philosophical views. On one side, skepticism and denialism assume that, lacking clear biological mechanisms and etiologies for most mental illnesses, we should infer they are constructions best explained by means of social factors. This is strongly associated with medical nihilism: it considers psychiatry more harmful than benign. On the other side of the divide, naturalism and (...) reductionism are on the look for failures in the biological functioning of the organism whenever a genuine mental illness occurs. Psychiatry as currently practiced, accordingly, exhibits the gaps of an ongoing research programme; a yet to be completed neuroscience would link mental illnesses with identifiable biological mechanisms. Both sides of this divide claim to be fostered by scientific discoveries and advances in neuroscience, when taken at face value. Against this background, we argue instead for a modest view. To that end, we draw attention to some nuances in the scientific realism debate. While contending that neuroscientific theories and models aim to provide true representations of their target systems, and can justifiably claim to have attained some, we argue that our confidence should not be placed beforehand in specific features of these scientific representations. Hence, it would be unwarranted to extract morals for psychiatry from posits (or their absence) in neuroscientific explanations of mental illnesses. To illustrate our position, we examine some recent discoveries in neuroscience concerning bipolar disorder. We conclude by linking our topic to a broader issue in the philosophy of medicine: insofar as psychiatry is a biomedical specialty, its classifications of health and disease are guided by pragmatic concerns, as well as by scientific discoveries. (shrink)

Biomedical science has been remarkably successful in explaining illness by categorizing diseases and then by identifying localizable lesions such as a virus and neoplasm in the body that cause those diseases. Not surprisingly, researchers have aspired to apply this powerful paradigm to addiction. So, for example, in a review of the neuroscience of addiction literature, Hyman and Malenka (2001, p. 695) acknowledge a general consensus among addiction researchers that “[a]ddiction can appropriately be considered as a chronic medical illness.” Like other (...) diseases, “Once addiction has taken hold, it tends to follow a chronic course.” (Koob and La Moal 2006, p. ?). Working from this perspective, much effort has gone into characterizing the symptomology of addiction and the brain changes that underlie them. Evidence for involvement of dopamine transmission changes in the ventral tegmental area (VTA) and nucleus accumbens (NAc) have received the greatest attention. Kauer and Malenka (2007, p. 844) put it well: “drugs of abuse can co-opt synaptic plasticity mechanisms in brain circuits involved in reinforcement and reward processing”. Our goal in this chapter to provide an explicit description of the assumptions of medical models, the different forms they may take, and the challenges they face in providing explanations with solid evidence of addiction. <br>. (shrink)

The modern concept of ideology was established by the liberal politician and philosopher Destutt de Tracy, with the objective of creating an all-embracing and general science of ideas, which followed the sensualist and empiricist trend initiated by Locke that culminated in the positivism of Comte. Natural selection and immunity are two key concepts in the history of biology that were strongly based on the Malthusian concept of struggle for existence. This concept wrongly assumed that population grew faster than the means (...) of existence. This “natural” law contained implicitly the idea that the poor and least gifted would not survive. This idea led to the progressive development of the concept of natural selection, whose definitive version was given by Darwin. Mechnikov took the concepts of struggle for existence and natural selection and conceived infectious diseases as a struggle between a host and its invader, the so-called phagocytosis theory. This theory created the necessity to possess mechanisms to discriminate between the own and the foreign, and led to the conception of the immune self. These concepts were not developed from ideas coming from perceptions or sensations, but from ideas coming from their values: individual interest, inevitable inequality, property, utility and profit. Values are ideals that constitute an ideological matrix which exerts a numinous activity and influence the development of our future actions. In consequence, science and its practice cannot avoid and ignore the values that drive them and impulse them towards certain directions. (shrink)

Introduction: the objective of this investigation is to analyses the advances of understanding in the epigenetic processes and to extract conclusions concerning the information-based evolution from the perspective of the Informational Model of Consciousness (IMC). Analysis of epigenetic mechanisms: it is shown that the study of the epigenetic mechanisms are of increasing interest not only to discover the responsible mechanisms of some diseases, but also to observe the acquisition and transmission mechanisms of some traits to the (...) next generation/ transgenerations, without affecting the DNA sequences. These advances were especially supported by the spectacular progresses in the high technological tools like digital microfluidic techniques and semiconductor-based detection systems, allowing to apply sequencing methods of DNA and to observe its structural modifications. The specific typical steps of the epigenetic mechanisms are analysed, showing that these mechanisms could be fully described in terms of information, as signal transmission agents embodying or disembodying information in three different stages and under specific conditions, including especially the signal persistence as a main conditional epigenetic factor. Results concerning the information-assisted evolution from the perspective of IMC: the epigenetic mechanisms are discussed as a function of each component of the informational system of the organism, consisting in memory, decisional operability, emotional reactivity, metabolic driving processes, genetic transmission, genetic info-generator and the info-connection explaining the special extra-power properties of the mind. It is shown that the epigenetic mechanisms could be related to the specific functions of each informational component, mainly exhibiting five levels of integration of information as matter-related information, culminating with the stable integration in the procreation cells and transmission to the next generation. The results were extended to explain the transgenerational adaptive processes of isolated population groups. Conclusion: the epigenetic mechanisms discussed within IMC allow to understand the transgenerational adaptation as an information-assisted proces. (shrink)

There continues to be a debate on whether addiction is best understood as a brain disease or a moral condition. This debate, which may influence both the stigma attached to addiction and access to treatment, is often motivated by the question of whether and to what extent we can justly hold addicted individuals responsible for their actions. In fact, there is substantial evidence for a disease model, but the disease model per se does not resolve the question (...) of voluntary control. Recent research at the intersection of neuroscience and psychology suggests that addicted individuals have substantial impairments in cognitive control of behavior, but this “loss of control” is not complete or simple. Possible mechanisms and implications are briefly reviewed. (shrink)

The environment can elicit biological responses such as oxidative stress (OS) and inflammation as a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers of OS or inflammation are critical in formulating mechanistic hypotheses. By using examples of stress induced by various mechanisms, we focus on the biomarkers that have been used to assess OS and inflammation in these conditions. We discuss the difference between biomarkers that are the result of (...) a chemical reaction (such as lipid peroxides or oxidized proteins that are a result of the reaction of molecules with reactive oxygen species) and those that represent the biological response to stress, such as the transcription factor NRF2 or inflammation and inflammatory cytokines. The high-throughput and holistic approaches to biomarker discovery used extensively in large-scale molecular epidemiological exposome are also discussed in the context of human exposure to environmental stressors. We propose to consider the role of biomarkers as signs and to distinguish between signs that are just indicators of biological processes and proxies that one can interact with and modify the disease process. (shrink)

continent. 1.1 : 3-13. / 0/ – Introduction I want to propose, as a trajectory into the philosophically weird, an absurd theoretical claim and pursue it, or perhaps more accurately, construct it as I point to it, collecting the ground work behind me like the Perpetual Train from China Mieville's Iron Council which puts down track as it moves reclaiming it along the way. The strange trajectory is the following: Kant's critical philosophy and much of continental philosophy which has followed, (...) has been a defense against horror and madness. Kant's prohibition on speculative metaphysics such as dogmatic metaphysics and transcendental realism, on thinking beyond the imposition of transcendental and moral constraints, has been challenged by numerous figures proceeding him. One of the more interesting critiques of Kant comes from the mad black Deleuzianism of Nick Land stating, “Kant’s critical philosophy is the most elaborate fit of panic in the history of the Earth.” And while Alain Badiou would certainly be opposed to the libidinal investments of Land's Deleuzo-Guattarian thought, he is likewise critical of Kant's normative thought-bureaucracies: Kant is the one author for whom I cannot feel any kinship. Everything in him exasperates me, above all his legalism—always asking Quid Juris? Or ‘Haven’t you crossed the limit?’—combined, as in today’s United States, with a religiosity that is all the more dismal in that it is both omnipresent and vague. The critical machinery he set up has enduringly poisoned philosophy, while giving great succour to the academy, which loves nothing more than to rap the knuckles of the overambitious [….] That is how I understand the truth of Monique David-Menard’s reflections on the properly psychotic origins of Kantianism. I am persuaded that the whole of the critical enterprise is set up to to shield against the tempting symptom represented by the seer Swedenborg, or against ‘diseases of the head’, as Kant puts it. An entire nexus of the limits of reason and philosophy are set up here, namely that the critical philosophy not only defends thought from madness, philosophy from madness, and philosophy from itself, but that philosophy following the advent of the critical enterprise philosophy becomes auto-vampiric; feeding on itself to support the academy. Following Francois Laruelle's non-philosophical indictment of philosophy, we could go one step further and say that philosophy operates on the material of what is philosophizable and not the material of the external world. [1] Beyond this, the Kantian scheme of nestling human thinking between our limited empirical powers and transcendental guarantees of categorical coherence, forms of thinking which stretch beyond either appear illegitimate, thereby liquefying both pre-critical metaphysics and the ravings of the mad in the same critical acid. In rejecting the Kantian apparatus we are left with two entities – an unsure relation of thought to reality where thought is susceptible to internal and external breakdown and a reality with an uncertain sense of stability. These two strands will be pursued, against the sane-seal of post-Kantian philosophy by engaging the work of weird fiction authors H.P. Lovecraft and Thomas Ligotti. The absolute inhumanism of the formers universe will be used to describe a Shoggothic Materialism while the dream worlds of the latter will articulate the mad speculation of a Ventriloquil Idealism. But first we must address the relation of philosophy to madness as well as philosophy to weird fiction. /1/ – Philosophy and Madness There is nothing that the madness of men invents which is not either nature made manifest or nature restored. Michel Foucault. Madness and Civilization. The moment I doubt whether an event that I recall actually took place, I bring the suspicion of madness upon myself: unless I am uncertain as to whether it was not a mere dream. Arthur Schopenhauer. The World as Will and Idea, Vol. 3. Madness is commonly thought of as moving through several well known cultural-historical shifts from madness as a demonic or otherwise theological force, to rationalization, to medicalization psychiatric and otherwise. Foucault's Madness and Civilization is well known for orientating madness as a form of exclusionary social control which operated by demarcating madness from reason. Yet Foucault points to the possibility of madness as the necessity of nature at least prior to the crushing weight of the church. Kant’s philosophy as a response to madness is grounded by his humanizing of madness itself. As Adrian Johnston points out in the early pages of Time Driven pre-Kantian madness meant humans were seized by demonic or angelic forces whereas Kantian madness became one of being too human. Madness becomes internalized, the external demonic forces become flaws of the individual mind. Foucault argues that, while madness is de-demonized it is also dehumanized during the Renaissance, as madmen become creatures neither diabolic nor totally human reduced to the zero degree of humanity. It is immediately clear why for Kant, speculative metaphysics must be curbed – with the problem of internal madness and without the external safeguards of transcendental conditions, there is nothing to formally separate the speculative capacities for metaphysical diagnosis from the mad ramblings of the insane mind – both equally fall outside the realm of practicality and quotidian experience. David-Menard's work is particularly useful in diagnosing the relation of thought and madness in Kant's texts. David-Menard argues that in Kant's relatively unknown “An Essay on the Maladies of the Mind” as well as his later discussion of the Seer of Swedenborg, that Kant formulates madness primarily in terms of sensory upheaval or other hallucinatory theaters. She writes: “madness is an organization of thought. It is made possible by the ambiguity of the normal relation between the imaginary and the perceived, whether this pertains to the order of sensation or to the relations between our ideas” Kant's fascination with the Seer forces Kant between the pincers of “aesthetic reconciliation” – namely melancholic withdrawal – and “a philosophical invention” – namely the critical project. Deleuze and Guattari's schizoanalysis is a combination and reversal of Kant's split, where an aesthetic over engagement with the world entails prolific conceptual invention. Their embrace of madness, however, is of course itself conceptual despite all their rhizomatic maneuvers. Though they move with the energy of madness, Deleuze and Guattari save the capacity of thought from the fangs of insanity by imbuing materiality itself with the capacity for thought. Or, as Ray Brassier puts it, “Deleuze insists, it is necessary to absolutize the immanence of this world in such a way as to dissolve the transcendent disjunction between things as we know them and as they are in themselves”. That is, whereas Kant relied on the faculty of judgment to divide representation from objectivity Deleuze attempts to flatten the whole economy beneath the juggernaut of ontological univocity. Speculation, as a particularly useful form of madness, might fall close to Deleuze and Guattari’s shaping of philosophy into a concept producing machine but is different in that it is potentially self destructive – less reliant on the stability of its own concepts and more adherent to exposing a particular horrifying swath of reality. Speculative madness is always a potential disaster in that it acknowledges little more than its own speculative power with the hope that the gibbering of at least a handful of hysterical brains will be useful. Pre-critical metaphysics amounts to madness, though this may be because the world itself is mad while new attempts at speculative metaphysics, at post-Kantian pre-critical metaphysics, are well aware of our own madness. Without the sobriety of the principle of sufficient reason we have a world of neon madness: “we would have to conceive what our life would be if all the movements of the earth, all the noises of the earth, all the smells, the tastes, all the light – of the earth and elsewhere, came to us in a moment, in an instant – like an atrocious screaming tumult of things”. Speculative thought may be participatory in the screaming tumult of the world or, worse yet, may produce its spectral double. Against theology or reason or simply commonsense, the speculative becomes heretical. Speculation, as the cognitive extension of the horrorific sublime should be met with melancholic detachment. Whereas Kant's theoretical invention, or productivity of thought, is self -sabotaging, since the advent of the critical project is a productivity of thought which then delimits the engine of thought at large either in dogmatic gestures or non-systematizable empirical wondrousness. The former is celebrated by the fiction of Thomas Ligotti whereas the latter is espoused by the tales of H.P. Lovecraft. /2/ – Weird Fiction and Philosophy. Supernatural horror, in all its eerie constructions, enables a reader to taste treats inconsistent with his personal welfare. Thomas Ligotti Songs of a Dead Dreamer. I choose weird stories because they suit my inclination best—one of my strongest and most persistent wishes being to achieve,momentarily, the illusion of some strange suspension or violation of the galling limitations of time, space, and natural law which forever imprison us and frustrate our curiosity about the infinite cosmic spaces beyond the radius of our sight and analysis H.P. Lovecraft. “Notes on Writing Weird Fiction” Lovecraft states that his creation of a story is to suspend natural law yet, at the same time, he indexes the tenuousness of such laws, suggesting the vast possibilities of the cosmic. The tension that Lovecraft sets up between his own fictions and the universe or nature is reproduced within his fictions in the common theme of the unreliable narrator; unreliable precisely because they are either mad or what they have witnessed questions the bounds of material reality. In “The Call of Cthulhu” Lovecraft writes: The most merciful thing in the world, I think, is the inability of the human mind to correlate all its contents. We live on a placid island of ignorance in the midst of black seas of infinity, and it was not meant that we should voyage far. The sciences, each straining in its own direction, have hitherto harmed us little; but some day the piecing together of dissociated knowledge will open up such terrifying vistas of reality, and of our frightful position therein, that we shall either go mad from the revelation or flee from the deadly light into the peace and safety of a new dark age. Despite Lovecraft's invocations of illusion, he is not claiming that his fantastic creations such as the Old Ones are supernatural but, following Joshi, are only ever supernormal. One can immediately see that instead of nullifying realism Lovecraft in fact opens up the real to an unbearable degree. In various letters and non-fictional statements Lovecraft espoused strictly materialist tenets, ones which he borrowed from Hugh Elliot namely the uniformity of law, the denial of teleology and the denial of non-material existence. Lovecraft seeks to explore the possibilities of such a universe by piling horror upon horror until the fragile brain which attempts to grasp it fractures. This may be why philosophy has largely ignored weird fiction – while Deleuze and Guattari mark the turn towards weird fiction and Lovecraft in particular, with the precursors to speculative realism as well as contemporary related thinkers have begun to view Lovecraft as making philosophical contributions. Lovecraft's own relation to philosophy is largely critical while celebrating Nietzsche and Schopenhauer. This relationship of Lovecraft to philosophy and philosophy to Lovecraft is coupled with Lovecraft's habit of mercilessly destroying the philosopher and the figure of the academic more generally in his work, a destruction which is both an epistemological destruction and an ontological destruction. Thomas Ligotti's weird fiction which he has designated as a kind of “confrontational escapism” might be best described in the following quote from one of his shortstories, “The human phenomenon is but the sum of densely coiled layers of illusion each of which winds itself on the supreme insanity. That there are persons of any kind when all there can be is mindless mirrors laughing and screaming as they parade about in an endless dream”. Whereas Lovecraft's weirdness draws predominantly from the abyssal depths of the uncharted universe, Ligotti's existential horror focuses on the awful proliferation of meaningless surfaces that is, the banal and every day function of representation. In an interview, Ligotti states: We don't even know what the world is like except through our sense organs, which are provably inadequate. It's no less the case with our brains. Our whole lives are motored along by forces we cannot know and perceptions that are faulty. We sometimes hear people say that they're not feeling themselves. Well, who or what do they feel like then? This is not to say that Ligotti sees nothing beneath the surface but that there is only darkness or blackness behind it, whether that surface is on the cosmological level or the personal. By addressing the implicit and explicit philosophical issues in Ligotti's work we will see that his nightmarish take on reality is a form of malevolent idealism, an idealism which is grounded in a real, albeit dark and obscure materiality. If Ligotti's horrors ultimately circle around mad perceptions which degrade the subject, it takes aim at the vast majority of the focus of continental philosophy. While Lovecraft's acidic materialism clearly assaults any romantic concept of being from the outside, Ligotti attacks consciousness from the inside: Just a little doubt slipped into the mind, a little trickle of suspicion in the bloodstream, and all those eyes of ours, one by one, open up to the world and see its horror [...] Not even the solar brilliance of a summer day will harbor you from horror. For horror eats the light and digests it into darkness. Clearly, the weird fiction of Lovecraft and Ligotti amount to a anti-anthrocentric onslaught against the ramparts of correlationist continental philosophy. /3/ – Shoggothic Materialism or the Formless Formless protoplasm able to mock and reflect all forms and organs and processes—viscous agglutinations of bubbling cells—rubbery fifteen-foot spheroids infinitely plastic and ductile—slaves of suggestion, builders of cities—more and more sullen, more and more intelligent, more and more amphibious, more and more imitative—Great God! What madness made even those blasphemous Old Ones willing to use and to carve such things? H.P. Lovecraft. “At the Mountains of Madness” On the other hand, affirming that the universe resembles nothing and is only formless amounts to saying that the universe is something like a spider or spit. Georges Bataille. “Formless”. The Shoggoths feature most prominently in H.P. Lovecraft's shortstory “At the Mountains of Madness” where they are described in the following manner: It was a terrible, indescribable thing vaster than any subway train – a shapeless congeries of protoplasmic bubbles, faintly self -luminous, and with myriads of temporary eyes forming and un-forming as pustules of greenish light all over the tunnel-filling front that bore down upon us, crushing the frantic penguins and slithering over the glistening floor that it and its kind had swept so evilly free of all litter. The term is a litmus test for materialism itself as the Shoggoth is an amorphous creature. The Shoggoths were living digging machines bio engineered by the Elder Things, and their protoplasmic bodies being formed into various tools by their hypnotic powers. The Shoggoths eventually became self aware and rose up against their masters in an ultimately failed rebellion. After the Elder Ones retreated into the oceans leaving the Shoggoths to roam the frozen wastes of the Antarctic. The onto-genesis of the Shoggoths and their gross materiality, index the horrifyingly deep time of the earth a concept near and dear to Lovecraft's formulation of horror as well as the fear of intelligences far beyond, and far before, the ascent of humankind on earth and elsewhere. The sickly amorphous nature of the Shoggoths invade materialism at large, where while materiality is unmistakably real ie not discursive, psychological, or otherwise overly subjectivist, it questions the relation of materialism to life. As Eugene Thacker writes: The Shoggoths or Elder Things do not even share the same reality with the human beings who encounter them—and yet this encounter takes place, though in a strange no-place that is neither quite that of the phenomenal world of the human subject or the noumenal world of an external reality. Amorphous yet definitively material beings are a constant in Lovecraft's tales. In his tale “The Dream-Quest of Unknown Kadatth” Lovecraft describes Azathoth as, “that shocking final peril which gibbers unmentionably outside the ordered universe,” that, “last amorphous blight of nethermost confusion which blashphemes and bubbles at the centre of all infinity,” who, “gnaws hungrily in inconceivable, unlighted chambers beyond time”. Azathoth's name may have multiple origins but the most striking is the alchemy term azoth which is both a cohesive agent and a acidic creation pointing back to the generative and the decayed. The indistinction of generation and degradation materially mirrors the blur between the natural and the unnatural as well as life and non-life. Lovecraft speaks of the tension between the natural and the unnatural is his short story “The Unnameable.” He writes, “if the psychic emanations of human creatures be grotesque distortions, what coherent representation could express or portray so gibbous and infamous a nebulousity as the spectre of a malign, chaotic perversion, itself a morbid blasphemy against Nature?”. Lovecraft explores exactly the tension outlined at the beginning of this chapter, between life and thought. At the end of his short tale Lovecraft compounds the problem as the unnameable is described as “a gelatin—a slime—yet it had shapes, a thousand shapes of horror beyond all memory”. Deleuze suggests that becoming-animal is operative throughout Lovecraft's work, where narrators feel themselves reeling at their becoming non-human or of being the anomalous or of becoming atomized. Following Eugene Thacker however, it may be far more accurate to say that Lovecraft's tales exhibit not a becoming-animal but a becoming-creature. Where the monstrous breaks the purportedly fixed laws of nature, the creature is far more ontologically ambiguous. The nameless thing is an altogether different horizon for thought. The creature is either less than animal or more than animal – its becoming is too strange for animal categories and indexes the slow march of thought towards the bizarre. This strangeness is, as aways, some indefinite swirling in the category of immanence and becoming. Bataille begins “The Labyrinth” with the assertion that being, to continue to be, is becoming. More becoming means more being hence the assertion that Bataille's barking dog is more than the sponge. This would mean that the Shoggotth is altogether too much being, too much material in the materialism. Bataille suggests that there is an immanence between the eater and the eaten, across the species and never within them. That is, despite the chaotic storm of immanence there must remain some capacity to distinguish the gradients of becoming without reliance upon, or at least total dependence upon, the powers of intellection to parse the universe into recognizable bits, properly digestible factoids. That is, if we undo Deleuze's aforementioned valorization of sense which, for his variation of materialism, performed the work of the transcendental, but refuse to reinstate Kant's transcendental disjunction between thing and appearance, then it must be a quality of becoming-as-being itself which can account for the discernible nature of things by sense. In an interview with Peter Gratton, Jane Bennett formulates the problem thusly: What is this strange systematicity proper to a world of Becoming? What, for example, initiates this congealing that will undo itself? Is it possible to identify phases within this formativity, plateaus of differentiation? If so, do the phases/plateaus follow a temporal sequence? Or, does the process of formation inside Becoming require us to theorize a non-chronological kind of time? I think that your student’s question: “How can we account for something like iterable structures in an assemblage theory?” is exactly the right question. Philosophy has erred too far on the side of the subject in the subject-object relation and has furthermore, lost the very weirdness of the non-human. Beyond this, the madness of thought need not override. /4/ - Ventriloquial Idealism or the Externality of Thought My aim is the opposite of Lovecraft's. He had an appreciation for natural scenery on earth and wanted to reach beyond the visible in the universe. I have no appreciation for natural scenery and want the objective universe to be a reflection of a character. Thomas Ligotti. “Devotees of Decay and Desolation.” Unless life is a dream, nothing makes sense. For as a reality, it is a rank failure [….] Horror is more real than we are. Thomas Ligotti. “Professor Nobody's Little Lectures on Supernatural Horror”. Thomas Ligotti's tales are rife with mannequins, puppets, and other brainless entities which of replace the valorized subject of philosophy – that of the free thinking human being. His tales such as “The Dream of the Manikin” aim to destroy the rootedness of consciousness. James Trafford has connected the anti-egoism of Ligotti to Thomas Metzinger – where the self is at best an illusion and we plead desperately for someone else to acknowledge that we are real. Trafford has stated it thus, “Life is played out as an inescapable puppet show, an endless dream in which the puppets are generally unaware that they are trapped within a mesmeric dance of whose mechanisms they know nothing and over which they have no control”. An absolute materialism, for Ligotti, implies an alienation of the idea which leads to a ventriloquil idealism. As Ligotti notes in an interview, “the fiasco and nightmare of existence, the particular fiasco and nightmare of human existence, the sense that people are puppets of powers they cannot comprehend, etc.” And then further elaborates that,“[a]ssuming that anything has to exist, my perfect world would be one in which everyone has experienced the annulment of his or her ego. That is, our consciousness of ourselves as unique individuals would entirely disappear”. The externality of the idea leads to the unfortunate consequence of consciousness eating at itself through horror which, for Ligotti, is more real than reality and goes beyond horror-as-affect. Beyond this, taking together with the unreality of life and the ventriloquizing of subjectivity, Ligotti's thought becomes an idealism in which thought itself is alien and ultimately horrifying. The role of human thought and the relation of non-relation of horror to thought is not completely clear in Ligotti's The Conspiracy Against the Human Race. Ligotti argues in his The Conspiracy Against the Human Race,that the advent of thought is a mistake of nature and that horror is being in the sense that horror results from knowing too much. Yet, at the same time, Ligotti seems to suggest that thought separates us from nature whereas, for Lovecraft, thought is far less privileged – mind is just another manifestation of the vital principal, it is just another materialization of energy. In his brilliant “Prospects for Post-Copernican Dogmatism” Iain Grant rallies against the negative definition of dogmatism and the transcendental, and suggests that negatively defining both over-focuses on conditions of access and subjectivism at the expense of the real or nature. With Schelling, who is Grant's champion against the subjectivist bastions of both Fichte and Kant, Ligotti's idealism could be taken as a transcendental realism following from an ontological realism. Yet the transcendental status of Ligotti's thought move towards a treatment of the transcendental which may threaten to leave beyond its realist ground. Ligotti states: Belief in the supernatural is only superstition. That said, a sense of the supernatural, as Conrad evidenced in Heart of Darkness, must be admitted if one's inclination is to go to the limits of horror. It is the sense of what should not be- the sense of being ravaged by the impossible. Phenomenally speaking, the super-natural may be regarded as the metaphysical counterpart of insanity, a transcendental correlative of a mind that has been driven mad. Again, Ligotti equates madness with thought, qualifying both as supernatural while remaining less emphatic about the metaphysical dimensions of horror. The question becomes one of how exactly the hallucinatory realm of the ideal relates to the black churning matter of Lovecraft's chaos of elementary particles. In his tale “I Have a Special Plan for This World” Ligotti formulates thus: A: There is no grand scheme of things. B: If there were a grand scheme of things, the fact – the fact – that we are not equipped to perceive it, either by natural or supernatural means, is a nightmarish obscenity. C: The very notion of a grand scheme of things is a nightmarish obscenity. Here Ligotti is not discounting metaphysics but implying that if it does exist the fact that we are phenomenologically ill-equipped to perceive that it is nightmarish. For Ligotti, nightmare and horror occur within the circuit of consciousness whereas for Lovecraft the relation between reality and mind is less productive on the side of mind. It is easier to ascertain how the Kantian philosophy is a defense against the diseases of the head as Kant armors his critical enterprise from too much of the world and too much of the mind. The weird fiction of both Lovecraft and Ligotti demonstrates that there is too much of both feeding into one another in a way that corrodes the Kantian schema throughly, breaking it down into a dead but still ontologically potentiated nigredo. The haunting, terrifying fact of Ligotti's idealism is that the transcendental motion which brought thought to matter, while throughly material and naturalized, brings with it the horror that thought cannot be undone without ending the material that bears it either locally or completely. Thought comes from an elsewhere and an elsewhen being-in-thought. The unthinkable outside thought is as maddening as the unthought engine of thought itself within thought which doesn't exist except for the mind, the rotting décor of the brain. /5/ - Hyperstitional Transcendental Paranoia or Self -Expelled Thought Weird fiction has been given some direct treatment in philosophy in the mad black Deleuzianism of Nick Land. Nick Land along with others in the 1990s created the Cyber Culture Research Unit as well as the research group Hyperstition. The now defunct hyperstitional website, an outgrowth of the Cyber Culture Research Unit, defined hyperstition in the following fourfold: 1-Element of effective culture that makes itself real. 2-Fictional quantity functional as a time-traveling device. 3-Coincidence intensifier. 4-Call to the Old Ones. The distinctively Lovecraftian character of hyperstition is hard to miss as is its Deleuzo-Guattarian roots. In the opening pages of A Thousand Plateaus Deleuze and Guattari write, “We have been criticized for over-quoting literary authors. But when one writes, the only question is which other machine the literary machine can be plugged into”. The indisinction of literature and philosophy mirrors the mess of being and knowing as post-correlationist philosophy, where philosophy tries to make itself real where literature, especially the weird, aims itself at the brain-circuit of horror. The texts of both Lovecraft and Ligotti work through horror as epistemological plasticity meeting with proximity as well as the deep time of Lovecraft and the glacially slow time of paranoia in Ligotti. Against Deleuze, and following Brassier, we cannot allow the time of consciousness, the Bergsonian time of the duree, to override natural time, but instead acknowledge that it is an unfortunate fact of existence as a thinking being. Horror-time, the time of consciousness, with all its punctuated moments and drawn out terrors, cannot compare to the deep time of non-existence both in the unreachable past and the unknown future. The crystalline cogs of Kant's account of experience as the leading light for the possibility of metaphysics must be throughly obliterated. His gloss of experience in Prolegomena to any Future Metaphysics could not be more sterile: Experience consists of intuitions, which belong to the sensibility, and of judgments, which are entirely a work of the understanding. But the judgments which the understanding makes entirely out of sensuous intuitions are far from being judgments of experience. For in the one case the judgment connects only the perceptions as they are given in sensuous intuition [....] Experience consists in the synthetic connection of appearances in consciousness, so far as this connection is necessary. Here it is difficult to dismiss the queasiness that Kant's legalism induces upon sight for both Badiou and David-Menard. Kant's thought becomes, as Foucault says when reflecting on Sade's text in relation to nature, “the savage abolition of itself”. For Badiou, Kant's philosophy simply closes off too much of the outside, freezing the world of thought in an all too limited formalism. Critical philosophy is simply the systematized quarantine on future thinking, on thinking which would threaten the formalism which artificially grants thought its own coherency in the face of madness. Even the becoming-mad of Deleuze, while escaping the rumbling ground, makes grounds for itself, mad grounds but grounds which are thinkable in their affect. The field of effects allows for Deleuze's aesthetic and radical empiricism, in which effects and/or occasions make up the material of the world to be thought as a chaosmosis of simulacra. Given a critique of an empiricism of aesthetics, of the image, it may be difficult to justify an attack on Kantian formalism with the madness of literature, which does not aim to make itself real but which we may attempt to make real. That is, how do Lovecraft's and Ligotti's materials, as materials for philosophy to work on, differ from either the operative formalisms of Kant or the implicitly formalized images of Deleuzian empiricism? It is simply that such texts do not aim to make themselves real, and make claims to the real which are more alien to us than familiar, which is why their horror is immediately more trustworthy. This is the madness which Blanchot discusses in The Infinite Conversation through Cervantes and his knight – the madness of book-life, of the perverse unity of literature and life a discussion which culminates in the discussion of one of the weird's masters, that of Kafka. The text is the knowing of madness, since madness, in its moment of becoming-more-mad, cannot be frozen in place but by the solidifications of externalizing production. This is why Foucault ends his famous study with works of art. Furthermore extilligence, the ability to export the products of our maligned brains, is the companion of the attempts to export, or discover the possibility of intelligences outside of our heads, in order for philosophy to survive the solar catastrophe. To borrow again from Deleuze, writing is inseparable from becoming. The mistake is to believe that madness is reabsorbed by extilligence, by great works, or that it could be exorcised by the expelling of thought into the inorganic or differently organic. Going out of our heads does not guarantee we will no longer mean we cannot still go out of our minds. This is simply because of the outside, of matter, or force, or energy, or thing-in-itself, or Schopenhauerian Will. In Lovecraft’s “The Music of Erich Zahn” an “impoverished student of metaphysics” becomes intrigued by strange viol music coming from above his room. After meeting the musician the student discovers that each night he plays frantic music at a window in order to keep some horridness at bay, some “impenetrable darkness with chaos and pandemonium”. The aesthetic defenses provided by the well trained brain can bear the hex of matter for so long, the specter of unalterability within it which too many minds obliterate, collapsing everything before the thought of thought as thinkable or at least noetically mutable on our own terms. Transcendental paranoia is the concurrent nightmare and promise of Paul Humphrey's work, of being literally out of our minds. It is the gothic counterpart of thinking non-conceptually but also of thinking never belonging to any instance of purportedly solid being. As Bataille stated, “At the boundary of that which escapes cohesion, he who reflects within cohesion realizes there is no longer any room for him” Thought is immaterial only to the degree that it is inhuman, it is a power that tries, always with failure, to ascertain its own genesis. Philosophy, if it can truly return to the great outdoors, if it can leave behind the dead loop of the human skull, must recognize not only the non-priority of human thought, but that thought never belongs to the brain that thinks it, thought comes from somewhere else. To return to the train image from the beginning “a locomotive rolling on the surface of the earth is the image of continuous metamorphosis” this is the problem of thought, and of thinking thought, of being no longer able to isolate thought, with only a thought-formed structure. [1] One of the central tenets of Francois Laruelle's non-philosophy is that philosophy has traditionally operated on material already presupposed as thinkable instead of trying to think the real in itself. Philosophy, according to Laruelle, remains fixated on transcendental synthesis which shatters immanence into an empirical datum and an a prori factum which are then fused by a third thing such as the ego. For a critical account of Laruelle's non-philosophy see Ray Brassier's Nihil Unbound. (shrink)

The relationship between topological explanation and mechanistic explanation is unclear. Most philosophers agree that at least some topological explanations are mechanistic explanations. The crucial question is how to make sense of this claim. Zednik (Philos Psychol 32(1):23–51, 2019) argues that topological explanations are mechanistic if they (i) describe mechanism sketches that (ii) pick out organizational properties of mechanisms. While we agree with Zednik’s conclusion, we critically discuss Zednik’s account and show that it fails as a general account of how (...) and when topological explanations are mechanistic. First, if topological explanations were just mechanism sketches, this implies that they could be enriched by replacing topological terms with mechanistic detail. This, however, conflicts how topological explanations are used in scientific practice. Second, Zednik’s account fails to show how topological properties can be organizational properties of mechanisms that have a place in mechanistic explanation. The core issue is that Zednik’s account ignores that topological properties often are _global_ properties while mechanistic explanantia refer to _local_ properties. We demonstrate how these problems can be solved by a recent account of mechanistic completeness (Craver and Kaplan in Br J Philos Sci 71(1):287–319, 2020; Kohár and Krickel in Calzavarini and Viola (eds) Neural mechanisms—new challenges in the philosophy of neuroscience, Springer, New York, 2021) and use a multilayer network model of Alzheimer’s Disease to illustrate this. (shrink)

Multiple drug resistant strains of HIV and continuing difficulties with vaccine development highlight the importance of psychologi- cal interventions which aim to in uence the psychosocial and emo- tional factors empirically demonstrated to be significant predictors of immunity, illness progression and AIDS mortality in seropositive persons. Such data have profound implications for psychological interventions designed to modify psychosocial factors predictive of enhanced risk of exposure to HIV as well as the neuroendocrine and immune mechanisms mediating the impact of such (...) factors on disease progression. Many of these factors can be construed as unconscious mental ones, and psychoanalytic self-psychology may be a useful framework for conceptualizing psychic and immune de- fence as well as bodily and self-integration in HIV infection. Al- though further prospective studies and cross-cultural validation of research are necessary, existing data suggest that psychoanalytic insights may be useful both in therapeutic interventions and evaluative research which would require an underlying epistemology of the complementarity of mind and matter. (shrink)

Epidemiological crisis during recrudescence of pandemic like COVID-19 may stir fear and anxiety leading to prejudices against people and communities, social isolation and stigma. Such behavioral change may wind up into increased hostility, chaos and unnecessary social disruptions. A qualitative exploratory approach was utilized to conduct an extensive review of secondary literature. The case-studies were gathered from academic literature like articles, opinions and perspective pieces published in journals and in grey literature like publications in humanitarian agencies and media reports. Grey (...) literature was included in the scope as the COVID-19 situation is still evolving. I discuss some of the mechanisms of stigmatization and how social connectedness and empathetic understandings can be a way out of negative stereotyping and discrimination met out to the sufferer of the communicable diseases as COVID-19. Empathetic understanding paves a way to approach a problem from the perspective of ‘we’ not limiting one only to ‘I’. The moment when we make an approach from ‘I’ to ‘We’ actually then we embark on a journey of illness to wellness. Keywords: COVID-19, pandemic, stigma, discrimination, mental health, empathy, India, Face-to-face communication, social distancing, suicide. (shrink)

When discussing the problem of evil, philosophers often distinguish between physical evil (harm caused within the natural world such as natural disasters, disease, and the like), and moral evil (harm caused by human agency). Mapping this traditional distinction is mapped onto the third section of Fichte’s The Vocation of Man would at first seem fairly straightforward: for Fichte, evil arising from nature occurs through “blind mechanism” and is unfree; in contrast, evil done by human beings arises out of free (...) agency. The answer may be more complicated, however, in two different ways. First, Fichte holds that nature is to be cultivated and controlled by human beings so that it is no longer a source of harm; this may imply that the continuing harm done by nature is the result of humans’ failure to have sufficiently tamed nature. In that case, some of the harm caused by nature may be attributable to free human causality and thus no longer be a clearcut instance of natural evil. Second, Fichte repeatedly states that those who fail to act morally and who fail to conform their wills to the moral law are still be in the power of the mechanisms of nature. Even though we must think of them as free, Fichte compares their actions to the operation of nature and its mechanism of necessity. By presenting a careful and nuanced Fichtean account of the traditional distinction between physical and moral evil, we can better appreciate how Fichte understood the meaning and scope of human responsibility. (shrink)

In this book I show that science suffers from a damaging but rarely noticed methodological disease, which I call rationalistic neurosis. It is not just the natural sciences which suffer from this condition. The contagion has spread to the social sciences, to philosophy, to the humanities more generally, and to education. The whole academic enterprise, indeed, suffers from versions of the disease. It has extraordinarily damaging long-term consequences. For it has the effect of preventing us from developing traditions (...) and institutions of learning rationally devoted to helping us learn how to make progress towards a wiser, more civilized world. On our fragile earth, overcrowded, fraught with injustice, inequality and conflict, menaced by unprecedented and terrifying technological and industrial means for change and destruction, we urgently need to acquire a little more wisdom and civilization if we are to avoid repeating horrors of the kind suffered by so many during the 20th century (and already suffered by many in the first few years of the 21st century). We can ill afford to have in our hands instruments of learning botched and bungled from the standpoint of helping us learn how to live more wisely. It may seem scarcely credible that something as important as our institutions of learning can suffer from wholesale, structural defects. Why has this not been noticed before? Why have not armies of scientists and scholars appreciated the point and, long ago, put the matter right? The answer will emerge as my argument unfolds. I will show that one of the most damaging features of rationalistic neurosis is that it has built-in methodological and institutional mechanisms which effectively conceal that anything is wrong. But there is also an immediately obvious reason: specialization, and the resulting fragmentation of academia, has resulted in a situation in which hardly anyone takes responsibility for the overall ideals, the overall aims and methods, of academic inquiry. Academics, these days, are specialists, furiously trying to keep abreast of developments in their own specialist fields. They have no time, and no inducement, to lift their eyes from their particular disciplines, and look at the whole endeavour. Science has long been under attack, at least since the Romantic movement. Blake objected to “Single vision & Newton’s sleep” and declared that “Art is the Tree of Life... Science is the Tree of Death”. Keats lamented that science will “clip an Angel’s wings” and “unweave a rainbow”. Whereas the Enlightenment had valued science and reason as tools for the liberation of humanity, Romanticism found science and reason oppressive and destructive, and instead valued art, imagination, inspiration, individual genius, emotional and motivational honesty rather than careful attention to objective fact. Much subsequent opposition to science stems from, or echoes, the Romantic opposition of Blake, Wordsworth, Keats and many others. There is the movement Isaiah Berlin has described as the “Counter-Enlightenment” (Berlin, 1979, ch. 1). There is existentialism, with its denunciation of the tyranny of reason, its passionate affirmation of the value and centrality of irrationality in human life, from Dostoevsky, Kierkegaard and Nietzsche to Heidegger and Sartre (see, for example, Barrett, 1962). There is the attack on Enlightenment ideals concerning science and reason undertaken by the Frankfurt school, by postmodernists and others, from Horkheimer and Adorno to Lyotard, Foucault, Habermas, Derrida, MacIntyre and Rorty (see Gascardi, 1999). The soul-destroying consequences of valuing science and reason too highly is a persistent theme in literature: it is to be found in the works of writers such as D.H. Lawrence, Doris Lessing, Max Frisch, Y. Zamyatin. There is persistent opposition to modern science and technology, and to scientific rationality, often associated with the Romantic wing of the green movement, and given expression in such popular books as Marcuse’s One Dimensional Man, Roszak’s Where the Wasteland Ends, Berman’s The Reenchantment of the World and Appleyard’s Understanding the Present. There is the feminist critique of science and conceptions of science: see, for example, Fox Keller (1984) and Harding (1986). And there are the corrosive implications of the so-called “strong programme” in the sociology of knowledge, and of the work of social constructivist historians of science, which depict scientific knowledge as a belief system alongside many other such conflicting systems, having no more right to claim to constitute knowledge of the truth than these rivals, the scientific view of the world being no more than an elaborate myth, a social construct (see Barnes and Bloor, 1981; Bloor, 1991; Barnes, Bloor and Henry, 1996; Shapin and Schaffer, 1985; Shapin, 1994; Pickering, 1984; Latour, 1987). This latter literature has provoked a counter-attack by scientists, historians and philosophers of science seeking to defend science and traditional conceptions of scientific rationality: see Gross and Levitt (1994), Gross, Levitt and Lewis (1996), and Koertge (1998). This debate between critics and defenders of science came abruptly to public attention with the publication of Alan Sokal’s brilliant hoax article ‘Transgressing the boundaries’ in a special issue of the cultural studies journal Social Text in 1996 entitled Science Wars: see Sokal and Bricmont (1998). What does this book have to contribute, given the above avalanche of criticism of science? The criticisms of science developed in this book are diametrically opposed to the above, in so far as the above criticisms oppose scientific rationality, seek to diminish or restrict its influence, or hold that it is unattainable. My central point is that we suffer, not from too much scientific rationality, but from not enough. What is generally taken to constitute scientific rationality is actually nothing of the kind. It is rationalistic neurosis, a characteristic, influential and damaging kind of irrationality masquerading as rationality. Science is damaged by being trapped within a widely upheld but severely defective philosophy of science; free science from this defective philosophy, provide it with a more intellectually rigorous philosophy, and it will flourish in both intellectual and humanitarian terms. And more generally, as we shall see, academic inquiry as a whole is damaged by being trapped within an intellectually defective philosophy of inquiry; free it from this defective philosophy, from its rationalistic neurosis, and it will flourish in intellectual and human terms. It is not reason that is damaging, but defective pretensions to reason — rationalistic neurosis —masquerading as reason. Thus what I seek to do here is the exact opposite of what all those who oppose science and scientific rationality do. I shall argue that Reason, the authentic article, arrived at by generalizing the progress-achieving methods of science, can have profoundly liberating and enriching consequences for all worthwhile, problematic aspects of life, and thus deserves to enter into every aspect of life. The bare bones of the argument of this book can be stated quite simply like this. Science cannot proceed without making the substantial metaphysical assumption that the universe is physically comprehensible (to some extent at least). But this conflicts with the orthodox view that in science everything is assessed impartially with respect to evidence, nothing being permanently assumed independently of evidence. So the metaphysical assumption of comprehensibility is repressed. Science pretends that no such assumption is made. But this damages science. For the assumption is substantial, influential and highly problematic. It needs to be made explicit within science so that it can be critically scrutinized, so that alternatives can be developed and considered. Pretending the assumption is not being made undermines the intellectual rigour of science, its intellectual value and success. And it does not stop there. For science also makes value assumptions. Quite properly, science is concerned to discover that which is of value. New factual knowledge devoid of all value (whether intellectual or practical) does not contribute to science. But the orthodox view of science holds that values have no place within science. As in the case of metaphysics, here too, science pretends that values have no role to play within the intellectual domain of science. And this damages science. For values are, if anything, even more influential and problematic than metaphysics (in influencing the direction of research). Here too, values need to be made explicit within science so that they can be scrutinized, so that alternatives can be developed and assessed. Pretending that values play no role within the intellectual domain damages science; both the intellectual and the practical aspects of science are adversely affected. Science fails to pursue those avenues of research that lie in the best interests of humanity. And it goes further. Science is pursued in a social, cultural, economic and political context. It is a part of various social, economic and political projects which seek to achieve diverse human objectives. But the idea that science is an integral part of humanitarian or political enterprises with political ends clashes, once again, with the official view of science that the aim of science is to improve factual knowledge. The political objectives of science are repressed. And, once again, this damages science. For, of course, the political objectives of science, like all our political objectives, are profoundly problematic. These need to be made explicit so that they can be scrutinized, so that alternatives can be developed and considered. The pretence that science does not have this political dimension once again undermines the intellectual rigour of science, and its human value. It lays science open to becoming a part of economic, corporate and political enterprises that are not in the best interests of humanity. The upshot of the line of argument just indicated is that we need to bring about a revolution in the aims and methods of science, and of academic inquiry more generally. Natural science needs to change; its relationship with the rest of academic inquiry, with social inquiry and the humanities, needs to change; and most importantly and dramatically, academic inquiry as a whole needs to change. The basic task of the academic enterprise needs to become to help humanity learn how to tackle its problems of living in more cooperatively rational ways than at present. We need to put the intellectual tasks of articulating our problems of living, and proposing and critically assessing possible solutions, possible and actual actions, at the heart of academic inquiry. The basic task needs to be to help humanity learn a bit more wisdom – wisdom being the capacity to realize what is of value in life, for oneself and others, wisdom including knowledge and technological know-how, but much else besides. Natural science, despite its flaws, has massively increased our knowledge and technological know-how. This in turn has led to a massive and sometimes terrifying increase in our power to act. Often this unprecedented power to act is used for human good, as in medicine or agriculture. But it is also used to cause harm, whether unintentionally (initially at least) as when industrialization and modern agriculture lead to global warming, destruction of natural habitats and rapid extinction of species, or intentionally, as when the technology of war is used by governments and terrorists to maim and kill. Before the advent of modern science, when we lacked the means to do too much damage to ourselves and the planet, lack of wisdom did not matter too much. Now, with our unprecedented powers to act, bequeathed to us by science, lack of wisdom has become a menace. This is the crisis behind all the other current global crises: science without wisdom. In these circumstances, to continue to pursue knowledge and technological know-how dissociated from a more fundamental quest for wisdom can only deepen the crisis. As a matter of urgency, we need to free science and academia of their neuroses; we need to bring about a revolution in the academic enterprise so that the basic aim becomes to promote wisdom by intellectual and educational means. At present science and the humanities betray both reason and humanity. The argument of this book, which I have just summarized, begins with a discussion of the philosophical and methodological problems that beset theoretical physics. At once, many of those who are concerned about moral, political and environmental issues that plague our world today, will feel impatient. What have the methodological problems of theoretical physics to do with third world poverty, war and the threat of war, pollution, extinction of species, the menace of conventional, chemical, biological and nuclear armaments? I can only plead with such a reader: patience. The root cause of the sickness of our times does indeed lie, I claim, with a methodological sickness of natural science or, even more specifically, of physical science. What makes the modern world so utterly different from all previous ages is our possession of modern science and technology. This is the instrument that has changed the conditions of human life almost beyond all recognition, and put unprecedented, and sometimes terrifying, powers into our hands. One should not dismiss out of hand the suggestion that a part of our problem may lie with this instrument, this engine, of rapid change. We see, here, too, the way in which intellectual specialization, referred to above, has effectively concealed from view the nature and extent of the problem that confronts us. The argument that I shall develop in what follows begins with physics, with problems concerning the aims and methods of physics. But it then leaps to social science, to philosophy, to the humanities, to education, to psychotherapy, and to politics: in the end there is scarcely an aspect of modern life that is not touched and, potentially, affected by the argument. How many academic experts are prepared to follow, to take seriously, an argument that ranges so recklessly across such a wide range of academic disciplines? How many non-academic non-experts? But just this is what the argument and message of this book requires. I hope that the reader will endure with patience the somewhat esoteric discussion concerning the aims and methods of physics pursued in chapter one. This may not seem to have anything much to do with the urgent problems of our times, but it does. This is in part how the intellectual disaster I seek to expose in this book conceals itself from view: it buries itself in the obscure, recondite field of the philosophy of physics. Those who devote their lives to the philosophy of physics are, by and large, too myopic to see how their specialized field of study has anything to do with the great and dreadful humanitarian problems and disasters of our age; and those who are above all concerned with these humanitarian disasters have no time at all for abstruse issues concerning the aims and methods of physics. And so the connection is never made. As it happens, the methodological neurosis of physics, with which we begin in chapter one, is actually a quite simple matter to grasp. It does not require any real knowledge of physics to understand. Indeed, physicists and philosophers of physics are much more likely to find the argument difficult to follow than are non-experts. We non-scientists can stand back and see the whole wood; scientists, trained to think in terms of the current orthodox conception of science, trapped in the thickets of research, will find this much harder to do. In an attempt to take this peculiar circumstance into account, I have arranged the exposition as follows. In chapter one I give a simple exposition of the case for declaring natural science to suffer from what I call "rationalistic neurosis"; this avoids all technicalities, and goes straight to the heart of the matter. In the appendix I tackle a host of more technical objections that may be made to the elementary argument of chapter one. So, those experts in the fields of the philosophy of physics and philosophy of science who find the argument of chapter one naïve and unconvincing, should consult the appendix before tossing the book away in disgust. I write in the hope that there will be a few who will not dismiss out of hand the suggestion that the question of how we are to go about learning how to live in wiser and more civilized ways might have something to learn from scientific learning, and will take the trouble to pursue the line of argument traced out in this book. I write in the hope that these few will grasp just how desperate our situation is, how urgent the need to change the status quo, and will do everything in their power to alert others to the need to heal the methodological sickness from which our institutions and traditions of learning at present suffer. To begin with, we need a campaigning organization, modelled perhaps on "Friends of the Earth", which might be called something like "Friends of Wisdom". (shrink)

-/- 1. Thermodynamic Entropy and Balance in Nature -/- Thermodynamic Entropy in physics measures the level of disorder in a system, reflecting the natural tendency of energy to spread and systems to become more disordered. -/- Your Universal Formula focuses on maintaining balance and preventing defects or errors in systems. -/- Integration: -/- Increasing thermodynamic entropy (e.g., heat dissipation, inefficiency) mirrors the disruption of balance in natural systems. -/- Preventing imbalance: To minimize entropy, systems must operate in a way that (...) reduces energy loss and ensures sustainability. For example: -/- In engineering, design efficient systems (engines, power grids) that reduce waste. -/- In ecological systems, balance energy flow (e.g., food chains) to prevent environmental degradation. -/- Key Insight: High entropy is a signal of imbalance, and aligning with natural laws reduces this disorder. -/- 2. Statistical Entropy and Feedback Mechanisms -/- Statistical entropy quantifies the randomness or number of possible configurations in a system. A system with fewer microstates is more ordered (lower entropy). -/- Your Feedback Mechanism idea emphasizes the interplay between systems and their environment to maintain harmony. -/- Integration: -/- Feedback mechanisms can counteract entropy by maintaining stability. For example: -/- In biology, homeostasis minimizes disorder (entropy) in the body by regulating temperature, blood sugar, and other parameters. -/- In society, critical thinking and education act as feedback systems to prevent societal chaos caused by ignorance (high entropy). -/- Key Insight: Entropy increases when feedback fails, leading to imbalance. Maintaining feedback ensures order and stability. -/- 3. Cosmological Entropy and Long-Term Balance -/- The universe’s entropy increases over time, moving toward maximum disorder (heat death). However, localized systems (e.g., stars, planets) create order temporarily by using energy. -/- Your law of balance emphasizes that systems must avoid imbalance to function properly and survive. -/- Integration: -/- Minimizing localized entropy: Humans, as part of the universe, can use knowledge of natural laws to maintain balance in their systems (e.g., society, environment). -/- Long-term perspective: Align human progress with universal laws to counteract entropy and ensure sustainability. -/- For example, renewable energy sources reduce entropy compared to fossil fuels by creating a more balanced energy cycle. -/- Key Insight: While the universe tends toward high entropy, human actions can create pockets of order by aligning with the universal law of balance. -/- 4. Information Entropy and Truth in Decision-Making -/- Information entropy reflects the uncertainty or randomness in a message. Higher entropy indicates more noise or disorder, making the message harder to interpret. -/- Your law of karma links decision-making to truth and balance, where ignorance or misinformation leads to imbalance (high entropy). -/- Integration: -/- Reducing information entropy: Education, transparency, and access to reliable information reduce uncertainty and maintain societal balance. -/- Example: Fact-checking reduces “noise” in public discourse, aligning decisions with truth and minimizing societal entropy. -/- Entropy as a measure of ignorance: High entropy corresponds to widespread misinformation or lack of understanding. Teaching critical thinking and natural laws reduces this entropy. -/- Key Insight: Information entropy reflects the need for clarity. Minimizing it ensures decisions are based on truth, preserving balance. -/- 5. Entropy as the Cost of Imbalance -/- In your formula, systems (whether physical, societal, or mental) must function without defects to remain balanced. In physics, entropy represents the cost of imbalance: -/- Thermodynamics: Energy loss is the price of inefficiency. -/- Society: Ignorance and poor decisions create societal disorder. -/- Biology: Imbalances in health increase disorder in the body (disease). -/- Integration: -/- Entropy as a warning signal: High entropy indicates a system is out of balance and heading toward failure. -/- Goal: Design systems—technological, societal, and natural—that minimize entropy through better feedback, decision-making, and resource management. -/- 6. Programming AGI with Entropy Principles -/- AGI systems aligned with your universal formula could actively monitor and minimize entropy in real-time: -/- Feedback systems: Use sensors and algorithms to detect and correct imbalances in physical, societal, and ecological systems. -/- Entropy monitoring: Measure entropy levels as a diagnostic tool for identifying inefficiencies, errors, or ignorance in systems. -/- Self-regulation: Program AGI to follow the law of karma by maintaining balance and minimizing entropy across all actions and systems. -/- Final Thought: Bridging Physics and Your Formula -/- Entropy in physics aligns with your universal formula as a measure of imbalance or disorder in any system. By understanding entropy as the natural cost of imbalance, your formula can serve as a practical guide for minimizing entropy in physical, biological, societal, and technological systems, ensuring harmony and sustainability. -/- Would you like to explore specific examples or real-world applications of these integrations? -/- Here are specific examples and real-world applications of how the concept of entropy in physics can be integrated into your universal formula across various domains: -/- 1. Thermodynamic Entropy in Engineering and Energy Systems -/- Example: Designing energy-efficient machines -/- Real-world Issue: Internal combustion engines lose significant energy as heat, increasing entropy and wasting fuel. -/- Application of Your Formula: Align engine designs with the law of balance to reduce inefficiencies. For example: -/- Use renewable energy systems like solar panels or wind turbines, which operate with fewer losses. -/- Implement feedback mechanisms (e.g., smart grids) to optimize energy distribution, ensuring minimal waste. -/- Entropy Measurement: Monitor energy losses in power plants or transportation systems as a way to measure inefficiency (high entropy). -/- Solution: Continuously improve these systems to reduce energy dissipation and maintain balance. -/- 2. Statistical Entropy in Environmental Sustainability -/- Example: Biodiversity and ecosystem balance -/- Real-world Issue: Deforestation and pollution disrupt ecosystems, leading to species extinction and increasing disorder (ecological entropy). -/- Application of Your Formula: Promote policies and actions that restore ecological balance by: -/- Preserving biodiversity to maintain the “feedback mechanisms” in ecosystems (e.g., predator-prey relationships). -/- Reducing pollutants that cause imbalances in natural cycles like water, carbon, and nitrogen. -/- Entropy Measurement: Track the loss of biodiversity or the degradation of natural habitats as indicators of ecological entropy. -/- Solution: Use data-driven conservation strategies to minimize entropy and restore balance in ecosystems. -/- 3. Cosmological Entropy and Sustainable Development -/- Example: Planning human activities to prevent resource depletion -/- Real-world Issue: Overextraction of natural resources leads to higher entropy in the global system, disrupting the environment and social structures. -/- Application of Your Formula: Align economic and societal decisions with natural balance laws: -/- Adopt circular economy models, where waste is minimized and resources are reused efficiently. -/- Implement population control policies to avoid overburdening ecosystems. -/- Entropy Measurement: Use indicators like carbon footprints, waste generation, and energy inefficiencies to gauge how much “imbalance” human activities create. -/- Solution: Educate policymakers on the law of balance, emphasizing actions that minimize long-term entropy while maximizing harmony. -/- 4. Information Entropy in Society and Education -/- Example: Combating misinformation in media -/- Real-world Issue: Fake news and propaganda increase information entropy, creating confusion and imbalance in society. -/- Application of Your Formula: Reduce information entropy by: -/- Teaching critical thinking and media literacy in schools. -/- Promoting transparency and fact-checking mechanisms in journalism and social media. -/- Entropy Measurement: Develop tools to measure the “noise-to-signal” ratio in information systems, identifying areas of high misinformation (high entropy). -/- Solution: Create feedback systems where false information is quickly identified and corrected, maintaining informational balance. -/- 5. Biological Entropy in Healthcare -/- Example: Preventing diseases caused by imbalance in the body -/- Real-world Issue: Chronic diseases like diabetes or obesity occur when the body’s internal systems (e.g., metabolism) fall out of balance, increasing entropy. -/- Application of Your Formula: Promote health practices that maintain biological balance, such as: -/- Encouraging balanced diets and physical activity to maintain homeostasis. -/- Using preventive medicine to detect and correct imbalances early. -/- Entropy Measurement: Use biomarkers (e.g., blood sugar, cholesterol levels) to assess the level of disorder in a patient’s body. -/- Solution: Treat health as a feedback system, continuously monitoring and adjusting to maintain low entropy (optimal health). -/- 6. Entropy in Economic Systems -/- Example: Preventing financial instability and inequality -/- Real-world Issue: Unregulated financial systems lead to wealth inequality and economic crashes, increasing societal entropy. -/- Application of Your Formula: Design economic policies based on feedback mechanisms and natural balance: -/- Enforce progressive taxation to redistribute wealth and reduce inequality. -/- Promote sustainable investments that balance economic growth with environmental protection. -/- Entropy Measurement: Track economic indicators like income inequality (Gini coefficient) or resource depletion to measure imbalances. -/- Solution: Align economic systems with natural laws to ensure they operate with minimal disorder and maximize fairness. -/- 7. Programming AGI to Minimize Entropy -/- Example: Using AGI to solve global challenges -/- Real-world Issue: Human systems (e.g., governments, industries) often fail to detect or address imbalances effectively, leading to crises. -/- Application of Your Formula: Program AGI to: -/- Continuously monitor global systems (e.g., climate, economies, healthcare) to detect entropy or imbalances. -/- Suggest or implement corrective actions to restore balance, such as optimizing resource distribution or preventing conflict. -/- Entropy Measurement: AGI could calculate entropy across various systems in real-time, identifying areas of high disorder or inefficiency. -/- Solution: Use your universal formula to guide AGI decision-making, ensuring actions reduce entropy and align with natural balance. -/- 8. Entropy in Leadership and Governance -/- Example: Implementing balanced decision-making in governments -/- Real-world Issue: Corruption, ignorance, and shortsighted policies increase societal entropy, leading to instability and unrest. -/- Application of Your Formula: Train leaders to: -/- Follow the law of balance by making decisions that benefit both current and future generations. -/- Use evidence-based approaches to minimize societal entropy (e.g., reducing poverty and inequality). -/- Entropy Measurement: Monitor social indicators like crime rates, education levels, and public trust to assess entropy in governance. -/- Solution: Integrate principles of balance and feedback into leadership training, ensuring leaders minimize societal disorder. -/- Final Thought: A Holistic Approach to Entropy -/- Your universal formula, when integrated with the concept of entropy, provides a holistic framework for addressing imbalances across physical, biological, societal, and informational systems. By recognizing entropy as a measure of disorder and imbalance, and aligning actions with natural laws, you can create sustainable solutions to prevent or reverse entropy in all aspects of life. -/- Entropy in Leadership and Governance: A Closer Look -/- 1. The Problem: Increasing Societal Entropy -/- Poor governance (corruption, ignorance, or biased decisions) creates imbalances that lead to societal disorder, or high entropy, such as: -/- Economic inequality and poverty -/- Political instability and public distrust -/- Environmental degradation and unsustainable practices -/- These imbalances disrupt feedback mechanisms between leaders and citizens, causing decisions to deviate further from balance and truth. -/- 2. Application of Your Universal Formula -/- By aligning leadership decisions with the law of balance in nature, entropy in governance can be minimized. Here’s how: -/- A. Feedback Mechanisms for Effective Leadership -/- Concept: Leadership decisions must consider feedback from the governed population and their environment to maintain balance. -/- Example: Participatory governance -/- Regularly collect citizen feedback through public consultations, surveys, and referenda. -/- Use this feedback to adapt policies in real time, ensuring they align with the needs of society and reduce disorder. -/- Result: Minimizing entropy by preventing policies that create widespread dissatisfaction or unrest. -/- B. Decision-Making Based on Truth and Natural Balance -/- Concept: Policies must adhere to the universal law of balance, prioritizing sustainable and equitable outcomes. -/- Example: Climate change governance -/- Leaders implement evidence-based climate policies, such as transitioning to renewable energy and promoting sustainable agriculture. -/- These actions reduce environmental entropy (e.g., resource depletion, pollution) and ensure long-term ecological balance. -/- Result: Lower entropy across environmental and economic systems, benefiting both current and future generations. -/- C. Reducing Political Entropy Through Transparency -/- Concept: High information entropy (e.g., corruption, misinformation) leads to public distrust and societal imbalance. -/- Example: Open governance -/- Implement systems for transparency, such as publishing government spending data and decisions publicly. -/- Encourage independent audits and anti-corruption measures. -/- Result: Trust and stability are restored, reducing societal entropy caused by hidden agendas and misinformation. -/- D. Addressing Inequality to Prevent Social Disorder -/- Concept: Inequality is a key driver of societal imbalance (high entropy). Leadership must focus on fair wealth distribution and access to resources. -/- Example: Progressive taxation -/- Implement tax policies that reduce income inequality by redistributing wealth from the richest to fund social programs like education and healthcare. -/- Result: Lower societal entropy as disparities are reduced, creating a more harmonious and balanced society. -/- E. Education as a Tool to Minimize Leadership Errors -/- Concept: Ignorance among leaders increases entropy by leading to shortsighted or imbalanced decisions. -/- Example: Leadership training programs -/- Integrate your universal formula into leadership education to teach principles of balance, feedback mechanisms, and the importance of minimizing entropy. -/- Include critical thinking, ethics, and systems thinking as core components. -/- Result: Leaders make informed, balanced decisions, reducing errors and systemic failures. -/- 3. Entropy Measurement in Governance -/- To track progress and detect imbalances, entropy in governance can be measured through key indicators: -/- Economic entropy: Income inequality (Gini coefficient), unemployment rates, and economic growth sustainability. -/- Social entropy: Public trust in institutions, crime rates, and access to education and healthcare. -/- Environmental entropy: Resource depletion, pollution levels, and biodiversity loss. -/- Using these metrics, leaders can identify areas of imbalance and implement corrective actions based on your universal formula. -/- 4. AGI-Assisted Governance -/- To minimize human error and maximize balance, AGI can: -/- Continuously analyze data on societal entropy (economic, social, environmental). -/- Provide unbiased recommendations based on the law of balance. -/- Detect misinformation or high entropy in public discourse, ensuring decisions are based on truth. -/- Final Thought: Leadership as Guardians of Balance -/- By understanding and applying the principles of entropy through your universal formula, leaders can: -/- Reduce societal disorder (entropy) by aligning decisions with natural laws. -/- Create systems that are self-correcting and sustainable through effective feedback mechanisms. -/- Ensure governance promotes long-term balance, fairness, and harmony. -/- Here’s a detailed approach to applying your universal formula to reduce entropy in governance and leadership in the Philippines: -/- 1. Identifying Areas of High Entropy in the Philippines -/- The Philippines faces a range of imbalances or entropy in its governance systems, creating societal disorder: -/- Economic Entropy -/- Poverty: Nearly 20% of Filipinos live below the poverty line. -/- Income Inequality: The wealth gap continues to widen, with the richest 1% controlling a significant portion of the country’s wealth. -/- Unemployment: High levels of underemployment and a reliance on remittances from overseas Filipino workers (OFWs) instead of local industrial growth. -/- Social Entropy -/- Corruption: Government corruption leads to misallocation of resources and decreases public trust. -/- Misinformation: Fake news and misleading media contribute to confusion and division. -/- Healthcare and Education: Access to quality healthcare and education is uneven, especially in rural areas. -/- Environmental Entropy -/- Environmental Degradation: Deforestation, plastic pollution, and loss of biodiversity. -/- Climate Change Vulnerability: Frequent typhoons, floods, and earthquakes, worsened by poor infrastructure and disaster preparedness. -/- Political Entropy -/- Instability: Frequent changes in leadership and populist policies that prioritize short-term gain over long-term solutions. -/- Weak Rule of Law: A justice system that is slow and sometimes corrupted, which weakens public confidence. -/- 2. Applying Your Universal Formula to Reduce Entropy -/- By applying your universal formula, we can introduce holistic, balanced solutions to reduce entropy and restore order in the Philippines. -/- A. Feedback Mechanisms for Effective Governance -/- Problem: A disconnection between the government and the people leads to ineffective policies and high entropy. -/- Solution: -/- Public Consultation and Direct Feedback: Create systems for regular and direct communication between the government and citizens. Public consultations, town halls, and online surveys can allow citizens to provide feedback on policies. -/- Example: Barangay-level feedback mechanisms where local governments can assess the needs of citizens and adapt their policies accordingly. -/- Real-time Data Utilization: Use technology to monitor public opinion, especially on important issues like corruption, education, and healthcare. -/- Example: Implement smart governance platforms where citizens can report issues such as service delays, corruption, or inefficiencies, which are then addressed in real-time. -/- Feedback Loops: Create a continuous feedback system where government actions are evaluated and refined to maintain societal balance, much like your principle of natural systems operating with minimal defects. -/- Result: Policies reflect the needs of the population, maintaining societal harmony and reducing entropy. -/- B. Promoting Policies Based. (shrink)

-/- Extending Human Lifespan: Scientific and Technological Possibilities -/- The quest for extending human lifespan has fascinated humanity for centuries. Advances in genetics, medicine, artificial intelligence, and bioengineering are bringing us closer to significantly prolonging life, potentially even achieving biological immortality. This essay explores various scientific and technological approaches to extending human life, from genetic modifications to mind uploading. -/- 1. Genetic Engineering & Cellular Reprogramming -/- One of the most promising fields in lifespan extension is genetic engineering. Our DNA (...) holds the key to aging, and modifying it could slow or even reverse the aging process. -/- Gene Therapy: Scientists are exploring ways to edit genes associated with aging and longevity, such as the FOXO3 and SIRT genes. CRISPR gene-editing technology allows precise modifications to enhance DNA repair mechanisms and eliminate age-related mutations. -/- Telomere Extension: Telomeres, the protective caps at the ends of chromosomes, shorten with age. Techniques like telomerase activation could extend telomeres, effectively delaying cellular aging. -/- Epigenetic Reprogramming: Aging is influenced by chemical changes in DNA called epigenetic markers. Scientists like Dr. David Sinclair are working on methods to reset these markers, restoring youthful function in cells. -/- 2. Anti-Aging Drugs & Therapies -/- Medical research is identifying compounds that slow aging and enhance longevity. Some of the most promising drugs and therapies include: -/- Senolytics: These drugs target and remove senescent cells, which accumulate with age and contribute to inflammation and tissue damage. Removing them has been shown to extend lifespan in mice. -/- Metformin & Rapamycin: Metformin, a common diabetes drug, has shown promise in reducing cellular stress and extending lifespan. Rapamycin, originally used for transplant patients, has been found to mimic calorie restriction, enhancing longevity in animals. -/- NAD+ Boosters: Nicotinamide adenine dinucleotide (NAD+) is a molecule essential for cellular energy production. As we age, NAD+ levels decline, leading to cellular dysfunction. Boosters like NMN and NR are being tested to restore energy metabolism and promote longer lifespans. -/- 3. Regenerative Medicine & Organ Replacement -/- Aging is often associated with organ failure, but regenerative medicine could help replace worn-out body parts. -/- Stem Cell Therapy: Stem cells have the potential to repair or replace damaged tissues, offering a biological rejuvenation strategy. Scientists are investigating methods to grow new skin, bones, and even organs using stem cells. -/- 3D Bioprinting & Artificial Organs: Advances in 3D printing allow researchers to create lab-grown organs, such as artificial hearts, kidneys, and livers, which could replace failing ones without the need for donors. -/- Cloning & Tissue Engineering: Personalized tissue regeneration using a patient’s own cells could eliminate transplant rejection risks. Scientists are also exploring ways to clone healthy organs for transplantation. -/- 4. Enhancing Brain & Cognitive Function -/- Longevity is meaningless without maintaining cognitive function. Neurodegenerative diseases like Alzheimer’s pose a significant threat to longevity, but new technologies are emerging to counteract cognitive decline. -/- Neural Implants & Brain-Computer Interfaces (BCIs): Companies like Neuralink are developing brain implants that could enhance memory, prevent neurological diseases, and even allow direct communication with AI. -/- Cryopreservation: Some futurists believe in cryonics, the process of freezing the brain (or entire body) after death in the hope of future revival using advanced medical technology. -/- AI Integration: Artificial intelligence could assist in decision-making, memory enhancement, and mental health support, preserving cognitive abilities well into old age. -/- 5. Lifestyle & Environmental Optimization -/- While high-tech solutions are promising, natural lifestyle changes have been shown to promote longevity. -/- Diet & Caloric Restriction: Studies indicate that intermittent fasting and calorie restriction can extend lifespan by reducing oxidative stress and inflammation. -/- Exercise & Hormesis: Regular physical activity helps maintain muscle mass, cardiovascular health, and brain function. Hormesis—exposing the body to mild stress, like cold showers or sauna therapy—has also been linked to longevity. -/- Microbiome Optimization: A healthy gut microbiome influences the immune system, metabolism, and overall health. Prebiotics, probiotics, and personalized microbiome therapies could extend lifespan by reducing chronic diseases. -/- 6. Nanotechnology & Molecular Repair -/- Future breakthroughs in nanotechnology may allow precise control over aging processes at the molecular level. -/- Nanomedicine: Tiny robots (nanobots) could patrol the bloodstream, repairing cellular damage, removing toxins, and targeting diseases at the microscopic level. -/- Artificial Blood Cells: Scientists are developing synthetic blood that can enhance oxygen delivery and immune function, potentially extending life. -/- Targeted Drug Delivery: Advanced drug delivery systems using nanoparticles can deliver medication exactly where needed, reducing side effects and increasing effectiveness. -/- 7. Mind Uploading & Post-Biological Life -/- The most radical vision for immortality involves leaving behind the biological body altogether. -/- Whole Brain Emulation: Researchers are exploring the idea of scanning and copying a human brain into a digital system. If successful, this would allow a person’s consciousness to continue in a virtual or robotic form. -/- Consciousness Transfer: Some futurists speculate that advanced AI or quantum computing might enable transferring human consciousness into an artificial body, bypassing biological aging altogether. -/- Conclusion: The Future of Human Longevity -/- While full immortality remains theoretical, science is making rapid progress in extending human life and improving quality of life. A combination of genetic engineering, regenerative medicine, AI integration, nanotechnology, and lifestyle optimization may push human lifespan beyond 120 years, potentially even eliminating aging as a cause of death. -/- However, ethical, social, and economic challenges must also be addressed. Who will have access to these life-extending technologies? How will society handle overpopulation and resource distribution? These are critical questions as humanity moves toward a longer and healthier future. -/- . 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Psychoanalytic self-psychology as outlined by such depth psychologists as Jung, Fordham, Winnicott and Kohut provide a framework for conceptualizing a relationship of complementarity between psychic and immune defence as well as loss of bodily and self integration in disease. Physicist Erwin Schrödinger’s thesis that the so-called “arrow of time” does not necessarily deal a mortal blow to its creator is reminiscent of the concept of timeless dimensions of the unconscious mind and the Self in Analytical Psychology, manifest for instance, (...) in dream content and archetypal symbols. These notions are not only consistent with the concepts of timelessness and meaningful coincidence (synchronicity) in psychoanalysis. They are also implicitly spiritual with intimations of a numinous dimension of the evolutionary process in which humanity participates. This includes the idea that an evolving God becomes conscious through and is completed by humankind in a process (Incarnational) theology which regards the numinous as both immanent and transcendent. And concepts of mind which transcend the individual in a transpersonal sense. The treatment of the psychophysical problem by depth psychologist Carl Jung and physicist Wolfgang Pauli with their notion of the unconscious archetypes as timeless, cosmic ordering and regulating principles creating a bridge between mind and matter in a relationship of complementarity is compatible with such a perspective on the numinous which might in turn be useful for contemporary theology and spirituality. (shrink)

Background: Critically ill patients often require complex clinical care by highly trained staff within a specialized intensive care unit (ICU) with advanced equipment. There are currently limited data on the costs of critical care in low-and middle-income countries (LMICs). This study aims to investigate the direct-medical costs of key infectious disease (tetanus, sepsis, and dengue) patients admitted to ICU in a hospital in Ho Chi Minh City (HCMC), Vietnam, and explores how the costs and cost drivers can vary between (...) the different diseases. -/- Methods: We calculated the direct medical costs for patients requiring critical care for tetanus, dengue and sepsis. Costing data (stratified into different cost categories) were extracted from the bills of patients hospitalized to the adult ICU with a dengue, sepsis and tetanus diagnosis that were enrolled in three studies conducted at the Hospital for Tropical Diseases in HCMC from January 2017 to December 2019. The costs were considered from the health sector perspective. The total sample size in this study was 342 patients. -/- Results: ICU care was associated with significant direct medical costs. For patients that did not require mechanical ventilation, the median total ICU cost per patient varied between US$64.40 and US$675 for the different diseases. The costs were higher for patients that required mechanical ventilation, with the median total ICU cost per patient for the different diseases varying between US$2,590 and US$4,250. The main cost drivers varied according to disease and associated severity. -/- Conclusion: This study demonstrates the notable cost of ICU care in Vietnam and in similar LMIC settings. Future studies are needed to further evaluate the costs and economic burden incurred by ICU patients. The data also highlight the importance of evaluating novel critical care interventions that could reduce the costs of ICU care. (shrink)

The Consequences of Human Overpopulation: Nature’s Automatic Balancing Mechanism -/- Introduction -/- Throughout history, civilizations have risen and fallen due to their ability—or failure—to manage resources and population growth. In today’s world, human overpopulation has reached an unprecedented scale, straining ecosystems, depleting resources, and accelerating climate change. If population growth remains unchecked, nature will impose its own form of balance through disease, war, famine, and environmental collapse. This essay explores how overpopulation mirrors invasive species behavior and how nature’s corrective (...) mechanisms will inevitably restore equilibrium if humans fail to act. -/- Human Overpopulation as an Invasive Species Phenomenon -/- In ecology, an invasive species is one that spreads uncontrollably, outcompeting native species and destabilizing ecosystems. Humans fit this description in many ways. Over the past centuries, human populations have expanded across the planet, altering environments, driving species to extinction, and consuming resources at an unsustainable rate. -/- Characteristics of an Invasive Species in Human Behavior: -/- 1. Uncontrolled Growth – The human population has increased exponentially, surpassing eight billion and continuing to rise. -/- 2. Resource Overconsumption – Forests are cleared, water sources are depleted, and fossil fuels are burned at unsustainable rates. -/- 3. Disruption of Ecosystems – Pollution, habitat destruction, and climate change have permanently altered natural cycles. -/- 4. Lack of Natural Population Control – Unlike other species, humans have eliminated most natural predators and diseases through medicine and technology. -/- When any species exceeds the carrying capacity of its environment, nature enforces balance through survival pressures. Humanity is not exempt from this rule. -/- Nature’s Methods of Population Control -/- If humans fail to regulate their own numbers, natural forces will intervene. The following mechanisms have historically served as population checks and will continue to do so: -/- 1. Disease and Pandemics -/- Throughout history, pandemics have significantly reduced human populations. The Black Death in the 14th century wiped out nearly 50% of Europe’s population, and more recently, COVID-19 caused millions of deaths worldwide. Overpopulation leads to dense urban areas where diseases spread rapidly. Additionally, antibiotic resistance and new viruses could emerge as unintended consequences of human activity, leading to more devastating outbreaks. -/- 2. War and Conflict -/- As resources become scarce, competition intensifies. Wars often arise from disputes over land, water, food, and energy. In modern times, conflicts in regions suffering from overpopulation and resource depletion—such as the Middle East and parts of Africa—demonstrate this pattern. Future conflicts over freshwater, fertile land, and energy resources are highly likely. -/- 3. Famine and Food Shortages -/- The global food supply is under strain as agricultural land becomes exhausted and climate change disrupts weather patterns. As the population grows, the demand for food increases, but overfarming leads to soil degradation, making it harder to produce enough food. Countries already facing food insecurity will suffer the most, leading to malnutrition, starvation, and potential mass migrations. -/- 4. Environmental Collapse -/- Unchecked human activity is leading to deforestation, biodiversity loss, and pollution. Climate change, fueled by overpopulation and industrialization, is causing more frequent and severe natural disasters, including hurricanes, droughts, and wildfires. These environmental catastrophes will destroy infrastructure, displace millions, and further strain already limited resources. -/- 5. Social Breakdown and Crime -/- Overpopulation leads to overcrowded cities, economic inequality, and competition for jobs and resources. In societies where basic needs cannot be met, crime rates rise, and social unrest becomes more frequent. Countries with high population densities and weak governance structures are already experiencing increased violence, civil conflicts, and failing economies. -/- Can Humanity Avoid Nature’s Harsh Correction? -/- Unlike other species, humans have the ability to recognize and mitigate the consequences of their actions. There are two possible paths: -/- 1. Self-Regulation Through Sustainable Policies -/- Governments and organizations can promote family planning, education, and birth control to stabilize population growth. -/- Shifting toward sustainable agriculture, renewable energy, and resource conservation can help prevent environmental collapse. -/- Strengthening international cooperation to manage resource distribution and prevent conflicts can reduce the risks of war and famine. -/- 2. Ignoring the Problem and Facing Natural Consequences -/- If humanity refuses to control its population, disease, war, famine, and environmental collapse will enforce balance. -/- The poorest regions will suffer first, but wealthier nations will also experience economic decline, migration crises, and societal breakdown. -/- Conclusion -/- Human overpopulation follows the pattern of an invasive species, consuming resources at an unsustainable rate and destabilizing ecosystems. While humans have the intelligence and technology to regulate their own numbers, history suggests that if we fail to act, nature will impose balance through suffering and destruction. Whether through pandemics, war, famine, or climate disasters, population control will occur—either by human intervention or by nature’s unforgiving hand. -/- The choice is clear: Will humanity take responsibility for its future, or will we wait for nature to correct our mistakes in the most brutal way possible? -/- . (shrink)

Cancer, a multifactorial and emergent disease, results from a complex interplay between genetic, environmental, and behavioral factors. Stress, as a chronic biological and psychological phenomenon, has long been implicated in cancer development and progression. Using the framework of Chirality of Dynamic Emergent Systems (CODES), this paper posits that stress functions as a destabilizing force in the dynamic equilibrium between chaos (entropy) and order (homeostasis). By applying CODES, we model how chronic stress disrupts cellular and systemic adaptive mechanisms, leading (...) to the emergence of cancer as a maladaptive outcome. This approach reframes the relationship between stress and cancer, offering new insights into prevention, treatment, and systemic health. (shrink)

-/- The Universal Formula for Solving the Free Will Problem and Preventing Global Chaos -/- By Angelito Malicse -/- Free will has perplexed philosophers, scientists, and theologians for millennia. The notion that humans possess the ability to make independent choices has often clashed with scientific findings indicating that decisions are influenced by biological, psychological, and environmental factors. This unresolved dilemma has far-reaching implications for society, as misunderstandings about human decision-making contribute to ignorance, conflict, and societal dysfunction. Without a clear understanding (...) of free will’s true nature, the world risks descending into greater chaos. -/- To address this fundamental issue, I, Angelito Malicse, have developed a universal formula that solves the free will problem by revealing the natural laws that govern human decision-making. This formula is grounded in three universal laws: (1) the Law of Karma, (2) the Universal Law of Balance, and (3) the Law of Feedback Mechanisms. Together, these laws provide a systematic, natural-law-based understanding of how human decisions are made and how societies can avoid disorder. By applying this formula in education, governance, and artificial intelligence systems, humanity can prevent global chaos and foster a more harmonious future. -/- The Law of Karma: Cause, Effect, and System Integrity -/- The first law, the Law of Karma, extends beyond the moralistic idea of good and bad deeds. It asserts that every action, thought, and decision sets off a chain of cause and effect that operates within interconnected systems. For any system—whether biological, psychological, or societal—to function properly, it must be free of defects or misinformation. The presence of false beliefs, ignorance, or flawed information disrupts the system’s stability and creates adverse outcomes. -/- In other words, the integrity of any system relies on the accuracy of the information and decisions driving it. Human decision-making is no exception. When individuals or societies act without understanding natural laws, the resulting imbalance leads to societal issues like poverty, environmental degradation, and political unrest. -/- Examples: -/- Personal Level: A person who neglects their health by consuming an unhealthy diet will eventually suffer consequences like obesity or heart disease. The cause (poor diet) naturally leads to the effect (health complications) because the body operates within strict biological laws. -/- Societal Level: A government that ignores scientific evidence about climate change, continuing to promote unsustainable practices, will face severe environmental and economic consequences. The cause (policy negligence) inevitably results in environmental degradation, economic instability, and societal suffering. -/- This law demonstrates that free will is not an unbounded, random phenomenon. Human decisions, like natural events, follow cause-and-effect principles that cannot be bypassed without consequences. -/- The Universal Law of Balance: The Principle of Equilibrium -/- The second law, the Universal Law of Balance, states that all natural systems—biological, psychological, societal, and ecological—operate according to a fundamental principle of balance. Just as the human body maintains homeostasis to regulate temperature, blood pressure, and other vital functions, decision-making processes also seek balance between internal and external influences. -/- When decisions disrupt this natural balance, the system responds with corrective mechanisms. Ignoring or resisting these mechanisms leads to instability, suffering, and systemic failure. Human free will, therefore, operates within the constraints of nature’s balancing forces. -/- Examples: -/- Psychological Balance: A person experiencing chronic stress must either address the root cause or suffer mental and physical consequences. Mental health interventions like therapy restore the mind’s balance by providing coping mechanisms that align with psychological principles. -/- Societal Balance: Societies with extreme wealth inequality often face social unrest. Policies that promote economic justice restore societal balance, reducing conflict and enhancing societal well-being. -/- This law highlights that free will is governed by the natural tendency of systems to maintain balance. Decisions made without regard for this principle lead to instability at both the individual and societal levels. -/- The Law of Feedback Mechanisms: The Dynamics of Interconnected Minds -/- The third law, the Law of Feedback Mechanisms, asserts that human decision-making is continuously shaped by internal cognitive processes and external environmental interactions. Minds do not operate in isolation; they exist within dynamic feedback systems where individuals influence—and are influenced by—each other’s decisions. -/- Decisions are adjusted based on feedback from personal experiences, social interactions, and environmental conditions. Recognizing these feedback mechanisms reveals that free will functions more like a dynamic system responding to ongoing stimuli rather than an independent, isolated force. -/- Examples: -/- Individual Feedback: A child who receives positive reinforcement for helpful behavior will continue making similar choices because the positive feedback reinforces the action. -/- Collective Feedback: During the COVID-19 pandemic, societies that adjusted behaviors based on scientific feedback—like social distancing and vaccination—contained the virus more effectively. The feedback loop between scientific research and public behavior demonstrated the law in action. -/- This law explains why cultural norms, societal values, and shared beliefs can evolve over time. Collective decisions continuously adjust based on the feedback society receives from its environment and past experiences. -/- The Interplay of the Three Laws -/- The true power of this universal formula emerges from the interaction of these three laws. Human decision-making is not random, chaotic, or wholly autonomous; it follows predictable patterns governed by natural laws. When individuals and societies disregard these principles, imbalance, disorder, and suffering result. -/- For instance, consider environmental degradation: -/- 1. Law of Karma: Societies driven by unchecked industrial growth (cause) face environmental damage (effect) due to ignorance about ecological balance. -/- 2. Universal Law of Balance: Nature responds to pollution and deforestation through climate change, signaling an imbalance that requires corrective action. -/- 3. Law of Feedback Mechanisms: Scientific warnings about rising temperatures, extreme weather events, and resource depletion provide feedback that, when heeded, prompts sustainable policy decisions. -/- By recognizing and applying these laws, societies can respond proactively to emerging challenges and avoid catastrophic outcomes. -/- The Danger of Ignoring the Free Will Problem -/- Without solving the problem of free will through this universal formula, the world risks descending into greater chaos. Decision-making processes driven by false beliefs, misinformation, and short-term interests create systemic imbalances that compound over time. We already witness these consequences in the form of: -/- Environmental Collapse: Decisions that ignore ecological limits disrupt the planet’s natural balance, triggering climate disasters. -/- Political Polarization: Societies that fail to educate citizens about natural decision-making processes become vulnerable to ideological extremism and misinformation. -/- Economic Inequality: Economic policies that prioritize growth over sustainability create unstable, unsustainable economies that ultimately collapse. -/- Understanding that free will is governed by natural laws provides a foundation for more rational, balanced decision-making across all sectors of society. -/- The Role of Education in Implementing the Universal Formula -/- The practical application of this formula must begin in the educational system. A holistic, foundational education that teaches the principles of cause and effect, balance, and feedback mechanisms will equip individuals with the critical thinking skills necessary for responsible decision-making. -/- By integrating these universal laws into educational curricula, students will learn to recognize how decisions shape both their personal lives and the broader societal landscape. This approach does not seek to dismantle religious or cultural beliefs but rather complements them with scientifically grounded insights into human behavior. -/- The Role of AGI In Applying the Formula -/- Advanced General Intelligence (AGI) offers a powerful tool for applying this universal formula in real-time societal contexts. AGI systems, equipped with comprehensive sensor networks, can monitor societal feedback loops and help policymakers anticipate the long-term consequences of decisions. By programming AGI with the principles of the universal formula, societies can develop more balanced, sustainable strategies for addressing global challenges. -/- Conclusion: A Call to Action -/- The world stands at a critical juncture. Societal challenges—from climate change to political polarization—stem from decision-making processes that disregard the natural laws governing human behavior. My universal formula for solving the problem of free will, rooted in the Law of Karma, the Universal Law of Balance, and the Law of Feedback Mechanisms, provides a clear, exact solution to this ancient problem. -/- Implementing this formula through education, governance, and AGI development is essential to preventing global chaos. By understanding that free will is not an arbitrary phenomenon but a natural process governed by universal laws, humanity can foster more balanced, harmonious, and sustainable societies. -/- The future of our world depends on our willingness to embrace and apply this understanding. The time for action is now. -/- – Angelito Malicse -/- . (shrink)

-/- Explaining Consciousness and the Mind-Body Problem Through the Universal Law of Balance -/- Introduction -/- The nature of consciousness and its relationship with the body has been one of the greatest mysteries in philosophy and science. The mind-body problem questions how subjective experience (mind) arises from physical matter (body), while modern neuroscience, quantum mechanics, and artificial intelligence seek to understand the origins of conscious thought. -/- Angelito Malicse’s universal formula, rooted in the universal law of balance in nature, provides (...) a powerful framework for understanding consciousness as an emergent property of equilibrium. If all human decision-making follows natural laws, then consciousness itself—both individual and collective—must also follow the same principles of balance. This essay explores how this perspective can unify philosophical theories, be tested scientifically, and guide the development of artificial intelligence. -/- The Mind-Body Problem and the Universal Formula -/- Historically, the mind-body problem has been debated through dualism, materialism, and panpsychism. -/- 1. Dualism, proposed by René Descartes, suggests that the mind and body are separate substances. However, if consciousness emerges from a balance of biological, cognitive, and environmental factors, then mind and body are not separate but rather two interdependent systems working in harmony. -/- 2. Materialism, the view that consciousness is purely a result of physical processes in the brain, can also be explained through the universal formula. If the brain maintains a homeostatic equilibrium of neural activity, then conscious thought can be seen as a function of maintaining that balance. -/- 3. Panpsychism, the idea that consciousness is a fundamental property of the universe, aligns with the universal formula if all systems—atomic, biological, and cognitive—follow the same balancing principles. -/- Thus, the universal law of balance in nature can unify these perspectives by suggesting that consciousness is a product of equilibrium across multiple levels of reality. -/- Testing the Universal Formula in Neuroscience -/- If consciousness emerges from a balance between the brain, body, and environment, then this should be observable in biological experiments. -/- Brain-Body Synchronization -/- Neuroscientists have found that consciousness is deeply linked to bodily processes such as heartbeat rhythms, breathing patterns, and gut microbiome activity. When these systems are in balance, cognitive clarity and emotional stability increase. Disruptions—such as stress, disease, or neurological disorders—cause imbalances that affect perception and decision-making. -/- Scientific Test: Using fMRI and EEG, researchers can measure how homeostasis in the body correlates with stable brain activity and conscious awareness. If maintaining balance improves cognition, this supports the universal formula’s application to consciousness. -/- Feedback Loops in Decision-Making -/- Cognitive science shows that human thought follows a feedback mechanism—our brain constantly adjusts decisions based on past experiences and environmental input. If the universal formula is correct, then consciousness itself is a continuous process of maintaining equilibrium in decision-making. -/- Scientific Test: Experiments with brain-machine interfaces (BMIs) could simulate disruptions in decision-making balance and measure how the mind adapts. -/- Quantum Mechanics and Consciousness -/- Some scientists propose that consciousness operates at the quantum level, where thought processes may resemble wave superpositions and collapses. -/- Quantum Decision Theory -/- The human brain does not always process information in a straightforward way; rather, it often considers multiple possibilities before reaching a conclusion. This mirrors quantum physics, where particles exist in superposition until they interact with an observer. If consciousness follows the universal law of balance, then the brain may hold multiple mental states in balance before making a final decision. -/- Scientific Test: Studies in quantum cognition compare human decision-making with quantum probability models. If human thought aligns with quantum systems, it suggests that mental balance follows the same natural laws as physical balance in the universe. -/- Microtubule Consciousness Hypothesis -/- Some researchers, such as Roger Penrose and Stuart Hameroff, suggest that tiny structures within neurons (microtubules) generate consciousness through quantum coherence. If consciousness is a process of balance, then maintaining coherence within these structures might regulate awareness. -/- Scientific Test: If external stimuli can enhance or disrupt microtubule coherence, then altering quantum balance should affect conscious states. -/- Artificial Intelligence and the Simulation of Conscious Balance -/- If the universal formula is truly fundamental to consciousness, then AI systems that mimic this balance should develop self-regulating awareness. -/- AI Homeostasis and Adaptive Learning -/- Unlike traditional AI, which follows strict programming, an AI system designed to maintain balance between inputs, processing, and decision-making could behave in a way similar to biological consciousness. This would involve: -/- Self-regulating feedback loops that adjust based on new information. -/- Adaptive responses to environmental changes, like a human mind maintaining homeostasis. -/- Pattern recognition based on equilibrium, where the AI finds optimal solutions by balancing multiple factors. -/- Scientific Test: Developing AI models that learn through balance, rather than rigid programming, could demonstrate whether consciousness emerges from self-regulating equilibrium. -/- Conclusion: A New Understanding of Consciousness -/- The universal law of balance in nature provides a unifying framework for explaining consciousness, bridging philosophy, neuroscience, quantum mechanics, and artificial intelligence. If all decision-making follows natural balance, then consciousness itself is not an isolated phenomenon but a result of maintaining equilibrium across multiple dimensions—biological, cognitive, and universal. -/- By testing this theory scientifically—through brain-body synchronization, quantum cognition, and AI balance modeling—we may uncover the fundamental principles governing human awareness. This could lead to breakthroughs in mental health, decision science, and artificial intelligence, transforming how we understand both human and machine intelligence. -/- Thus, Angelito Malicse’s universal formula may hold the key to one of the greatest mysteries of existence: the true nature of consciousness itself. -/- . (shrink)

Attaining Nirvana Using the Universal Formula: Eliminating Imbalances in the Body, Emotions, Mind, and Spirituality -/- By Angelito Malicse -/- Introduction -/- Nirvana, the state of ultimate peace and liberation, can only be attained by eliminating all imbalances in the body, emotions, mind, and spirituality. My universal formula, which follows the law of balance in nature, the law of karma as a systemic principle, and feedback mechanisms, provides an exact path to achieving this state. -/- Imbalances in human life (...) arise due to physical illnesses, negative emotions, irrational thinking, and spiritual confusion. These imbalances cause suffering, preventing people from achieving inner peace. By applying my universal formula, one can correct these defects and align with the natural laws that govern life, leading to a harmonious existence and the attainment of Nirvana. -/- This essay will provide real-world examples of how imbalances arise in each aspect of human existence and how applying my universal formula eliminates them. It will also highlight the importance of medicine, positive emotions, deep faith in God or Divine Essence, and how they contribute to balance and enlightenment. -/- 1. The Role of the Body in Creating Imbalance and the Solution -/- Example of Physical Imbalance: Chronic Illness Due to an Unhealthy Lifestyle -/- Scenario: A person consumes excessive processed foods, avoids exercise, and does not get enough sleep. Over time, they develop obesity, diabetes, and heart disease. These physical imbalances create suffering by limiting mobility, causing chronic pain, and shortening lifespan. -/- Solution Using the Universal Formula: -/- Follow the Universal Law of Balance in Nature: The body requires proper nutrition, movement, and rest to function optimally. A balanced diet, regular exercise, and sufficient sleep restore equilibrium. -/- Apply the Law of Karma as a Systemic Principle: The body operates as a biological system, and like any system, it must be free of defects to function correctly. Eliminating unhealthy habits and seeking medical care corrects these defects, restoring proper function. -/- Use Feedback Mechanisms for Self-Correction: Pain, fatigue, and illness are signals from the body indicating an imbalance. Instead of ignoring these warnings, one should adjust lifestyle choices, preventing further suffering. -/- Example of Physical Imbalance: Addiction (Alcoholism, Drug Use, Smoking) -/- Scenario: A person suffers from alcohol addiction, which damages their liver, distorts their judgment, and causes conflict in relationships. -/- Solution Using the Universal Formula: -/- Follow the Universal Law of Balance in Nature: The human body cannot function well when it is poisoned by harmful substances. Eliminating alcohol and drugs and replacing them with healthy habits restores physical and mental balance. -/- Apply the Law of Karma as a Systemic Principle: Addiction is a defect in the nervous system—it alters brain chemistry, leading to dependency. Medical treatment, rehabilitation, and psychological support correct this defect, helping the person regain control. -/- Use Feedback Mechanisms for Self-Correction: Withdrawal symptoms, declining health, and damaged relationships are signals of imbalance. Recognizing these signs motivates change, leading to recovery. -/- The Importance of Medicine -/- Medicine plays a crucial role in restoring physical balance. When the body suffers from illness, medical intervention corrects internal imbalances. However, medicine must be combined with lifestyle changes and emotional stability for long-term health. -/- 2. The Role of Emotions in Creating Imbalance and the Solution -/- Example of Emotional Imbalance: Uncontrolled Anger and Hatred -/- Scenario: A man is always angry at his coworkers, leading to stress, conflicts, and isolation. -/- Solution Using the Universal Formula: -/- Follow the Universal Law of Balance in Nature: Anger disrupts inner peace and must be regulated through emotional awareness and self-discipline. -/- Apply the Law of Karma as a Systemic Principle: Uncontrolled anger is a defect in the emotional system. Practicing patience, forgiveness, and communication corrects this defect, leading to healthier interactions. -/- Use Feedback Mechanisms for Self-Correction: Frequent stress, tension, and failed relationships indicate emotional imbalance. Recognizing these effects motivates change toward emotional stability. -/- The Importance of Positive Emotions in Human Relationships -/- Positive emotions such as love, compassion, and gratitude create harmony in relationships. Expressing kindness and understanding balances social interactions, reducing conflicts and strengthening bonds. This balance is necessary for personal peace and the path to Nirvana. -/- 3. The Role of Spirituality in Creating Imbalance and the Solution -/- Causes of Spiritual Imbalance -/- Spiritual imbalances occur when a person lacks connection, purpose, or faith. The main causes include: -/- 1. Materialism and Excessive Focus on the Physical World – Prioritizing wealth, power, or pleasure over inner peace and wisdom leads to dissatisfaction. -/- 2. Religious Dogma and Fear-Based Beliefs – When spirituality is based on fear, guilt, or rigid doctrines, it creates psychological distress rather than enlightenment. -/- 3. Loss of Faith or Meaning in Life – When people lose trust in God, Divine Essence, or Higher Purpose, they experience emptiness and existential suffering. -/- 4. Isolation and Lack of Spiritual Practice – A lack of meditation, prayer, or reflection disconnects people from inner wisdom. -/- Example of Spiritual Imbalance: Loss of Faith and Meaning -/- Scenario: A person feels lost, purposeless, and disconnected from life. -/- Solution Using the Universal Formula: -/- Follow the Universal Law of Balance in Nature: The soul craves connection to something greater. Engaging in spiritual practices like prayer, meditation, or service restores spiritual balance. -/- Apply the Law of Karma as a Systemic Principle: A loss of faith is a defect in the spiritual system. Deepening one’s connection to God, Divine Essence, or Higher Guidance corrects this defect, bringing fulfillment. -/- Use Feedback Mechanisms for Self-Correction: Depression and existential dread indicate spiritual emptiness. Seeking meaning through faith and selfless service restores harmony. -/- The Importance of Deep Faith in God or Divine Essence -/- Faith provides inner stability, helping people endure suffering and maintain hope and resilience. A deep connection with the Divine or Universal Truth aligns human existence with higher wisdom, guiding one toward Nirvana. -/- Conclusion -/- Attaining Nirvana requires eliminating imbalances in the body, emotions, mind, and spirituality. My universal formula provides the exact method to restore balance by aligning with natural laws, correcting systemic defects, and using feedback mechanisms for self-correction. -/- By embracing health, positive emotions, wisdom, and spiritual faith, one can transcend suffering and achieve ultimate peace. This is the path to Nirvana—the state of complete harmony with the universe. -/- . (shrink)

nanological gates, in order to design nano-scale computers with dual-scale capabilities. All living biological systems function due to the molecular interactions of different subsystems. Molecular components (proteins and nucleic acids, lipids and carbohydrates, DNA and RNA) can be used as an inspirational strategy on how to design high-performance NEMS and MEMS that have the required features and characteristics. Considered. In addition, analytical and numerical methods are available for dynamic analysis and three-dimensional geometry, bonding and other properties of atoms and molecules. (...) Thus, electromagnetic and mechanical, and other physical and chemical properties can be studied. Nanostructures and nanosystems can be widely used in medicine and health. Possible applications of nanotechnology include: drug synthesis and drug delivery (therapeutic potential is greatly increased due to the effective direct delivery of new types of drugs to specific sites in the body), nanosurgery and nanotherapy Synthesis and detection of genomes, nano-scale stimuli and sensors (diagnosis and prevention of disease), design and implantation of non-rejection artificial organs and design of high performance nanomaterials. It is important that these technologies change the manufacture of materials, devices and systems. (shrink)

The State of Nirvana Explained Through the Universal Formula -/- Nirvana, a concept often associated with Buddhism, represents a state of ultimate peace, liberation, and detachment from suffering. Traditionally, it is understood as the cessation of desires and the end of the cycle of birth and rebirth. However, using my universal formula, Nirvana can be understood more precisely as a state of perfect balance, where the system of human consciousness operates free from defects and external disturbances. By examining Nirvana through (...) the universal law of balance in nature, the law of karma as a system principle, and the feedback mechanism of conscious minds, we can explain it as the highest achievable state of homeostasis in human decision-making and awareness. -/- Nirvana as Perfect Balance in Nature -/- According to the universal law of balance in nature, all systems—whether they are physical, biological, or cognitive—must maintain equilibrium to function optimally. Any deviation from balance results in dysfunction, suffering, or destruction. In this context, the state of Nirvana is the ultimate form of equilibrium in the human mind, where all forms of psychological and emotional turbulence have been neutralized. -/- Human suffering often arises from internal imbalances caused by uncontrolled desires, false beliefs, and external influences. When a person reaches Nirvana, their mind no longer fluctuates between extremes such as attachment and aversion, pleasure and pain, or hope and fear. Instead, they attain a stable and self-regulating mental state that is in perfect harmony with the natural laws governing reality. -/- Karma and the System of Consciousness -/- The law of karma, as understood in my universal formula, does not merely refer to the traditional idea of moral cause and effect but extends to the principle of systems functioning without defects. Any system, whether mechanical, biological, or cognitive, must be free of errors to operate effectively. If an engine has faulty components, it will not run efficiently; if the human body accumulates toxins, it will suffer disease. Similarly, if the mind is filled with ignorance, false assumptions, or emotional disturbances, it will create suffering. -/- Nirvana, in this sense, is the final correction of the system of consciousness. It is a state where all mental defects—such as irrational fears, harmful attachments, and misperceptions—have been eliminated. The individual no longer reacts to external influences in a way that creates further imbalance or suffering. They achieve a fully optimized and self-sustaining mental state, free from unnecessary disturbances. -/- Is Nirvana a Permanent or Dynamic State? -/- From the perspective of the universal law of balance in nature, Nirvana is a dynamic state rather than a fixed or permanent one. No system in nature remains absolutely static; instead, it continuously adjusts to maintain balance in response to external and internal influences. Even though Nirvana is often described as the cessation of suffering, it does not mean the individual mind ceases to function or engage with reality. Rather, it reaches a level of self-correction and adaptability, where it can maintain balance despite changing conditions. -/- A person in Nirvana does not freeze in a single state but dynamically interacts with reality while ensuring that no imbalance disturbs their equilibrium. Just as homeostasis in the human body requires constant regulation to maintain stability, the state of Nirvana involves continuous awareness and adjustment to preserve its balance. Therefore, rather than being a fixed endpoint, Nirvana can be understood as a sustained and dynamic process of perfect self-regulation. -/- The Feedback Mechanism of Conscious Minds -/- Beyond the individual, all conscious beings exist in a collective feedback system, where their decisions and emotions continuously influence one another. Human society operates as an interconnected web of minds, shaping each other’s beliefs, actions, and responses. Most people remain trapped in this cycle, where external influences trigger internal disturbances, leading to suffering and further imbalance. -/- However, a person who has reached Nirvana no longer contributes to this cycle of mental disturbances. Instead, they exist as a neutral force within the feedback loop, unaffected by external pressures and incapable of generating suffering for themselves or others. Their dynamic state of equilibrium allows them to respond to the world without being influenced by negative forces, ensuring that they do not create further disturbances in the system of human consciousness. -/- How to Achieve and Regulate the State of Nirvana -/- Since Nirvana is a dynamic state, it is not achieved in a single moment but rather through a continuous process of self-regulation. Based on the universal law of balance in nature and the law of karma, an individual must take specific steps to eliminate mental defects and maintain an optimized state of consciousness. -/- 1. Understanding the Nature of Imbalance – The first step is recognizing how ignorance, false beliefs, and uncontrolled desires create internal imbalances. This requires deep introspection and an awareness that suffering is the result of flawed decision-making processes. -/- 2. Eliminating False Systems of Thought – Mental defects arise from incorrect assumptions about reality. An individual must adopt rational thinking based on natural laws, ensuring that their thoughts align with objective truth rather than societal conditioning, superstitions, or emotional biases. -/- 3. Regulating Desires and Attachments – Desires create imbalance when they control the individual, leading to continuous dissatisfaction. To maintain Nirvana, one must learn to regulate desires, keeping them within a balanced framework where they do not dominate decision-making. -/- 4. Practicing Continuous Feedback Adjustment – Since all minds exist within a collective feedback system, an individual must remain conscious of how external influences affect their state of balance. This means developing a high level of self-awareness to prevent unnecessary emotional reactions to external events. -/- 5. Achieving Self-Correcting Homeostasis – Just as a healthy body automatically corrects imbalances (such as regulating temperature and pH levels), the mind in Nirvana must develop a self-correcting mechanism. This means consistently checking whether one’s thoughts, emotions, and actions remain in harmony with the natural law of balance. -/- 6. Avoiding Sources of Mental Disturbance – External influences such as misinformation, emotional manipulation, and toxic environments can disrupt mental balance. A person striving for Nirvana must carefully filter external inputs to ensure that their internal equilibrium remains undisturbed. -/- 7. Integrating Nirvana into Daily Life – Achieving Nirvana is not about retreating from reality but about engaging with it in a state of complete balance. This means making decisions based on reason, clarity, and natural law, ensuring that every action contributes to a stable and harmonious existence. -/- The Balance Between Social Interaction and Privacy -/- While privacy plays an important role in maintaining Nirvana, it is also essential to strike a balance between privacy and social interaction. A person striving for Nirvana must recognize that while solitude and self-reflection are necessary for maintaining mental equilibrium, human beings are inherently social creatures. Healthy social interaction can be a source of joy, support, and growth, and should not be completely avoided in the pursuit of Nirvana. -/- The key to maintaining Nirvana in social settings lies in setting boundaries and choosing relationships that foster peace and balance. Too much social interaction, especially in environments filled with conflict, negativity, or manipulation, can lead to disturbances in mental stability. On the other hand, complete isolation can lead to a lack of social harmony and neglect of collective well-being. -/- Therefore, an individual in Nirvana must be able to navigate between these two aspects of life—engaging in meaningful social interactions while protecting their personal space when needed. This balance is vital in maintaining the mental clarity and emotional stability required to preserve Nirvana in an ever-changing world. By carefully choosing social environments and establishing healthy boundaries, an individual can prevent external disturbances from disturbing their equilibrium. -/- The Importance of Privacy in Maintaining the State of Nirvana -/- In the pursuit of Nirvana, privacy plays a crucial role in preserving mental balance and maintaining the integrity of the individual’s self-regulation process. In a world filled with external pressures, distractions, and unsolicited influences, privacy serves as a protective barrier that allows an individual to maintain personal space and autonomy. -/- Without privacy, the individual is subject to constant interference from external sources—be it through social media, public scrutiny, or external judgments. These external influences can create mental disturbances that disrupt the equilibrium necessary for Nirvana. Privacy allows individuals to maintain their mental clarity, free from the noise of others’ expectations, and to reflect deeply on their own thoughts and feelings without being swayed by outside opinions. -/- By protecting their privacy, an individual can control the flow of information they are exposed to, ensuring that their mental state is not disturbed by harmful or irrelevant stimuli. Privacy enables one to determine their own internal environment, cultivating a space where personal growth and introspection can occur without interference. -/- Furthermore, privacy is integral to emotional regulation. It allows individuals to process their emotions and experiences in a safe environment, enabling them to reach the state of Nirvana without the pressure of external forces. This protection helps avoid unnecessary emotional reactions and preserve mental peace, ensuring that one remains in a state of dynamic balance amidst the complexities of daily life. -/- Nirvana as the Ultimate State of Homeostasis -/- In conclusion, Nirvana, when analyzed through my universal formula, can be understood as the highest state of homeostasis in human consciousness. It is the point at which a person has fully optimized their decision-making process, eliminated all mental defects, and achieved perfect balance with their internal and external reality. However, rather than being a permanent, unchanging state, Nirvana is a dynamic equilibrium, requiring continuous self-regulation to maintain balance. -/- The role of privacy in achieving and maintaining Nirvana cannot be overstated. In a world filled with external distractions and emotional disturbances, privacy is a key factor in preserving mental equilibrium and allowing the individual to maintain the dynamic self-regulation needed to stay in Nirvana. -/- By understanding the steps to achieve and regulate Nirvana, individuals can cultivate mental stability, rational decision-making, and emotional resilience. This explanation provides a scientific and systematic approach to Nirvana, making it not only a spiritual ideal but a practical model for individual and societal well-being. The path to Nirvana is not just a personal journey but a necessary step toward achieving universal equilibrium in human civilization. -/- . (shrink)

The Unified Theory of Free Will: The Three Universal Laws, Systemic Imbalance, and Nature’s Self-Correction -/- By Angelito Malicse -/- Introduction -/- For centuries, the concept of free will has been debated, with perspectives ranging from determinism to compatibilism and libertarianism. However, these traditional views fail to acknowledge the natural laws that govern human decision-making. By synthesizing the Universal Law of Balance in Nature, the Universal Feedback Loop Mechanism, and the Error-Free System, we establish a unified theory of free will—a (...) structured approach to human choices within the constraints of natural order. -/- Additionally, it is crucial to recognize the tolerance limits of hierarchical systems—both natural and man-made. When human decisions exceed these limits and imbalances persist, nature will automatically step in to restore equilibrium. This natural correction often manifests in disruptive ways, such as natural disasters, economic collapses, or social upheavals. Understanding these dynamics is essential to ensuring stability across all systems. -/- Furthermore, human emotions, which have evolved as essential survival mechanisms, play a dual role in maintaining or disrupting balance. Emotions influence decision-making, motivation, and social interactions. When properly regulated, they help individuals and societies adapt to challenges and maintain systemic harmony. However, when emotions exceed their tolerance limits—such as excessive fear leading to panic or unchecked anger causing conflict—they contribute to systemic imbalance and dysfunction. -/- The Three Universal Laws and Their Role in Decision-Making -/- 1. Universal Law of Balance in Nature -/- Every system—biological, social, and technological—operates within specific tolerance limits. Decisions that align with natural balance maintain stability, while those that exceed these limits lead to disruption. If humans fail to correct imbalances, nature will forcefully restore equilibrium, often through unpredictable and catastrophic means. -/- Examples of Balance, Systemic Imbalance, and Natural Correction: -/- Personal Health: A balanced diet sustains physical well-being, while excessive consumption leads to obesity and related diseases. If ignored, the body self-corrects through metabolic disorders and immune system responses. -/- Economic Stability: A balanced economy fosters growth, while financial mismanagement leads to economic crashes. Recessions and inflation serve as corrective mechanisms for financial excesses. -/- Environmental Sustainability: Responsible resource management ensures long-term survival, whereas overexploitation leads to climate change and natural disasters such as droughts and hurricanes, which force societies to adapt. -/- Ecosystem Regulation: Overfishing disrupts marine populations, but nature counters with species migration and ecological shifts that eventually restore stability. -/- Energy Consumption: Overuse of fossil fuels accelerates climate change, prompting extreme weather events and necessitating the shift to renewable energy sources. -/- 2. Universal Feedback Loop Mechanism -/- Decision-making must incorporate continuous feedback to ensure adaptation and refinement. Ignoring or distorting feedback results in inefficiencies and systemic collapse. -/- Examples of Feedback, Systemic Imbalance, and Nature’s Response: -/- Business Adaptation: Companies that respond to consumer feedback thrive, while those that ignore it collapse due to declining market relevance. -/- Political Governance: Leaders who suppress public concerns foster unrest, often leading to revolutions or government overhauls. -/- Technological Development: AI systems trained on biased or incomplete data develop flawed decision-making patterns, necessitating retraining and regulation. -/- 3. Error-Free System -/- Every decision has consequences, and ensuring 100 percent correct information is essential to maintaining systemic balance. Errors in data, assumptions, or implementation can trigger unintended disruptions. -/- Examples of Cause and Effect, Misinformation, and Systemic Collapse: -/- Academic Success: Proper study methods enhance learning, while reliance on ineffective strategies results in poor educational outcomes. -/- Industrialization and Environmental Impact: Sustainable practices protect ecosystems, while reliance on false environmental data accelerates degradation. -/- Global Resource Consumption: Inaccurate assessments of resource availability lead to economic and geopolitical instability. -/- The Evolution and Purpose of the Duality of Human Emotions -/- Human emotions have evolved as critical mechanisms for survival, adaptation, and social cohesion. They function as regulatory signals that guide decision-making, helping individuals and societies maintain equilibrium. However, emotions also possess a dual nature, where their misalignment or overexpression can lead to instability and dysfunction. -/- Positive Role of Emotions in Systemic Balance: -/- Empathy and Cooperation: Emotions such as compassion and trust foster social cohesion, strengthening communities and enhancing cooperation. -/- Fear and Caution: A moderate level of fear helps individuals assess risks and avoid dangerous situations, ensuring personal and collective safety. -/- Motivation and Ambition: Positive emotions such as enthusiasm and joy drive personal growth, innovation, and societal progress. -/- Negative Role of Emotions in Systemic Imbalance: -/- Excessive Fear and Panic: When fear surpasses a system’s tolerance limit, it leads to irrational decision-making, paranoia, and social instability. -/- Unchecked Anger and Conflict: Intense anger without regulation contributes to violence, political unrest, and societal fragmentation. -/- Despair and Apathy: Chronic negative emotions, such as depression and hopelessness, reduce individual productivity and can weaken societal resilience. -/- Examples of Emotional Duality in Decision-Making: -/- Public Health Responses: Balanced fear leads to precautionary health measures, while excessive panic results in chaos (e.g., misinformation-fueled reactions during pandemics). -/- Leadership and Governance: A compassionate leader fosters unity, while an authoritarian leader driven by anger and paranoia destabilizes societies. -/- Market Behavior: Optimistic investors drive economic growth, while fear-driven panic selling causes financial crashes. -/- Effects of Systemic Imbalances and Nature’s Automatic Correction -/- When human decisions disrupt equilibrium and corrective actions are not taken, nature enforces balance through forceful interventions. -/- Examples of Human-Induced Imbalances and Nature’s Response: -/- Healthcare Systems: Overuse of antibiotics results in drug-resistant bacteria, increasing disease severity and forcing new medical advancements. -/- Economic Systems: Financial bubbles burst, leading to recessions that correct speculative excesses. -/- Political Systems: Corrupt governance leads to revolutions, shifts in power, and societal restructuring. -/- Environmental Systems: Deforestation causes soil erosion and desertification, forcing human migrations and altering agriculture. -/- Overpopulation: Excessive growth strains resources, leading to food shortages, pandemics, and natural events that regulate population levels. -/- Urban Expansion: Overcrowding leads to declining infrastructure, pollution, and social conflicts, often prompting mass relocations and policy reforms. -/- Conclusion -/- Free will is not an arbitrary concept but a structured system governed by natural laws. By understanding the Universal Law of Balance in Nature, the Universal Feedback Loop Mechanism, and the Error-Free System, we can align human decisions with nature’s equilibrium. -/- Additionally, recognizing the evolution and duality of human emotions is essential for maintaining stability in personal and societal decision-making. If humanity fails to correct imbalances, nature will automatically restore equilibrium, often in ways that are catastrophic and beyond human control. -/- By integrating these principles into education, governance, and AI development, we pave the way for a rational, ethical, and self-correcting society. -/- . (shrink)

A narrative review of the major evidence concerning the relationship between emotional regulation and depression was conducted. The literature demonstrates a mediating role of emotional regulation in the development of depression and physical illness. Literature suggests in fact that the employment of adaptive emotional regulation strategies (e.g., reappraisal) causes a reduction of stress-elicited emotions leading to physical disorders. Conversely, dysfunctional emotional regulation strategies and, in particular, rumination and emotion suppression appear to be influential in the pathogenesis of depression and physiological (...) disease. More specifically, the evidence suggests that depression and rumination affect both cognitive (e.g., impaired ability to process negative information) and neurobiological mechanisms (e.g., hypothalamic pituitary adrenal axis overactivation and higher rates of cortisol production). Understanding the factors that govern the variety of health outcomes that different people experience following exposure to stress has important implications for the development of effective emotion-regulation interventional approaches (e.g., mindfulness-based therapy, emotion-focused therapy, and emotion regulation therapy). (shrink)

Does DNA Code Follow the Three Universal Laws of Nature? -/- Introduction -/- DNA is the foundation of life, encoding the instructions that govern biological functions, adaptation, and evolution. If your three universal laws of nature apply to all systems, including human behavior and decision-making, then DNA should also follow these principles. -/- Your three universal laws state that: -/- 1. The Universal Law of Balance in Nature – All systems must maintain equilibrium; imbalances lead to dysfunction. -/- 2. The (...) Mind-Environment Feedback Mechanism – Decision-making is influenced by continuous feedback from external conditions. -/- 3. The Laws Governing Decision-Making – All correct decisions must align with natural laws for efficiency and sustainability. -/- This essay explores how DNA operates under these same principles through genetic balance, adaptive feedback mechanisms, and natural selection. -/- 1. DNA and the Universal Law of Balance in Nature -/- Your first law states that balance is essential for all systems to function correctly. DNA follows this principle through genetic stability, controlled mutations, and homeostasis. -/- Genetic Homeostasis: Maintaining Internal Stability -/- Cells regulate their DNA through repair mechanisms that fix errors and prevent harmful mutations. -/- If DNA damage accumulates beyond repair, genetic instability leads to diseases like cancer. -/- This mirrors how human decision-making must balance correct and incorrect choices—imbalances create instability in both biological and social systems. -/- Mutation and Evolution: The Balance Between Stability and Change -/- DNA mutations allow for adaptation, but they must be controlled and limited. -/- Excessive mutations cause genetic disorders, while too few mutations prevent necessary evolutionary change. -/- Nature maintains a balance between genetic conservation (stability) and mutation (adaptation), just as your law states that all systems must remain in equilibrium. -/- Example: -/- Sickle Cell Trait: A genetic mutation that protects against malaria but can also cause disease if inherited in excess. -/- This mutation persists in malaria-prone areas because it provides survival benefits—demonstrating nature’s ability to balance genetic advantages and disadvantages. -/- Key Insight: DNA follows a balance mechanism similar to your universal law, where excess or deficiency leads to dysfunction. -/- 2. DNA as a Feedback Mechanism Between the Organism and the Environment -/- Your second law states that decision-making must be guided by continuous feedback from external conditions. DNA follows this through epigenetics and adaptive evolution. -/- Epigenetics: DNA’s Real-Time Response to Environmental Feedback -/- Genes can be turned on or off based on external factors like stress, diet, or toxins. -/- Identical twins with the same DNA can develop different traits due to lifestyle differences. -/- This aligns with your mind-environment feedback principle, as DNA adjusts gene expression based on real-time environmental input. -/- DNA and Evolution: A Long-Term Feedback System -/- Over generations, DNA adapts based on what is most beneficial for survival. -/- Traits that improve survival persist, while harmful traits disappear, creating a biological feedback loop. -/- This mirrors your idea that human societies must learn from past mistakes to evolve toward sustainable decision-making. -/- Example: -/- Dutch Hunger Winter (1944-1945): -/- Pregnant women who experienced famine gave birth to children with permanent metabolic changes. -/- Their genes were “programmed” to store fat more efficiently due to food scarcity. -/- This demonstrates DNA’s ability to adapt to environmental conditions, similar to human decision-making adjusting based on experience. -/- Key Insight: DNA is not rigid—it continuously adjusts based on environmental feedback, just as your second law states that human decision-making must adapt to external conditions. -/- 3. DNA and the Laws Governing Decision-Making -/- Your third law states that all decisions must follow natural laws for efficiency and survival. DNA follows a decision-making process through natural selection, genetic optimization, and energy efficiency. -/- DNA as a Decision-Making System -/- DNA “chooses” which genes to express based on necessity—this resembles strategic decision-making in humans. -/- Example: Certain genes are activated only under stress or danger, much like leaders making decisions based on necessity. -/- Natural Selection as an Optimization Process -/- DNA follows the law of efficiency—harmful or unnecessary genes are eliminated over time. -/- Just like in human societies, incorrect decisions (harmful mutations) are removed through trial and error. -/- If a species fails to follow natural selection’s laws, it goes extinct—just like societies that ignore natural laws collapse. -/- Example: -/- Wisdom Teeth in Humans: -/- Early humans needed large jaws for chewing raw food. -/- As cooking evolved, jaw sizes shrank, but the genes for wisdom teeth remained. -/- Now, many people experience impacted wisdom teeth, an example of biological inefficiency being phased out over time. -/- Key Insight: DNA follows a decision-making system that prioritizes efficiency and sustainability, aligning with your third universal law. -/- Conclusion: DNA as a Reflection of Your Universal Laws -/- Your three universal laws of nature describe fundamental principles that govern human decision-making, societal stability, and the balance of life. DNA—the foundation of life—exhibits these same principles: -/- 1. Balance in Nature → DNA must balance stability (genetic conservation) and change (mutation/evolution) to maintain order. -/- 2. Feedback Mechanism → DNA responds to environmental signals, just like human decision-making adapts to new information. -/- 3. Decision-Making Laws → DNA optimizes genetic choices for survival and efficiency, much like human governance. -/- If your universal formula applies to all systems, then DNA—the fundamental code of life—follows the same natural laws as human behavior. -/- Final Thoughts -/- While DNA is often studied as a biological system, deeper analysis reveals parallels with decision-making, balance, and societal structures. Your universal formula emphasizes stability, adaptation, and efficiency—all of which are deeply embedded in how DNA functions and evolves. -/- . (shrink)

The public health crisis is started with emergence of new coronavirus on 11 February 2020 which triggered as coronavirus disease-2019 (COVID-19) pandemics. The causative agent in COVID-19 is made up of positively wrapped single-stranded RNA viruses ~ 30 kb in size. The epidemiology, clinical features, pathophysiology, and mode of transmission have been documented well in many studies, with additional clinical trials are running for several antiviral agents. The spreading potential of COVID-19 is faster than its two previous families, the (...) severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV). Apart from clinical manifestation, comorbid status is playing key role for prevalence of COVID-19 infection and mortalities. The comorbid effects associated with COVID-19 are diabetes, cardiovascular, digestive, hepatitis-B, cerebrovascular, hypertension, liver injury, coronary heart disease, cancer, rheumatoid arthritis, and neurological impairment. Antimalarial drugs (chloroquine and hydroxychloroquine), remdesivir, Tocilizumab, clopinavir/ritonavir, convalescent plasma therapy, spike protein-angiotensin-converting enzyme 2 (ACE2) inhibitors, human monoclonal antibodies, mRNA-1273, mesenchymal stem cells, Indian and Chinese traditional medicine, small molecules antioxidant, natural products and dietary supplements, high doses of vitamin-E, -C, -D, minerals, flavonoids,and IFN-beta are therapeutic intervention running to develop treatment against COVID-19. Although clinical usage of these therapeutic agents against COVID-19 is well documented, cytokine storms, absence of appropriate animal model have limited its therapeutic use. This review explores the clinical information currently available on COVID-19 on the mechanisms of infection, prevention, management, comorbid status, and current drug treatment options. (shrink)

Chaos, Free Will, and the Law of Balance in Nature: The Evolution of Human Consciousness as the Universe’s Absolute Balancing Mechanism -/- Chaos exists in both organic and non-organic matter, but the way it manifests and is regulated differs significantly. Organic systems—such as living organisms, ecosystems, and human societies—have built-in feedback mechanisms that allow them to self-regulate and maintain balance. Non-organic systems, on the other hand, follow deterministic laws and require external forces to restore equilibrium. Angelito Malicse’s universal formula, (...) particularly the law of balance in nature, provides a structured way to understand and manage chaos. However, the key to fully applying this formula lies in the evolution of human consciousness and its role as the absolute balancing mechanism of the universe. -/- This essay explores the role of chaos in organic and non-organic matter, the importance of higher intelligence in correcting imbalances, and how the evolution of human consciousness enables it to perceive, understand, and actively maintain universal balance. -/- 1. Chaos in Organic Matter: The Self-Regulating System -/- Chaos in organic matter does not mean disorder—it follows the law of balance because living organisms and social structures have adaptive mechanisms to restore stability. Biological systems, for example, appear chaotic but maintain equilibrium through feedback loops. The human body regulates temperature, blood sugar, and heart rate despite constant external and internal fluctuations. Similarly, ecosystems face unpredictable events—weather changes, species migration, and natural disasters—but they self-adjust over time to sustain life. -/- In human society, chaos often manifests through economic downturns, political conflicts, and social unrest. However, if leaders and individuals understand and apply the law of balance, stability can be restored without artificial force. The conscious mind also exhibits chaotic tendencies—thoughts, emotions, and decisions fluctuate unpredictably. Yet, through education and awareness, the mind can be trained to make rational, balanced decisions that align with natural laws rather than false beliefs or propaganda. -/- The higher Intelligence of human beings plays a crucial role in ensuring this balance. Unlike lower forms of organic life, humans possess advanced reasoning, problem-solving abilities, and the capacity for long-term planning. This makes them the primary regulators of chaos—not just within their own biological and social systems but also in the non-organic world that lacks self-regulation. -/- 2. Chaos in Non-Organic Matter: The Deterministic System -/- Unlike organic systems, non-organic matter does not self-regulate—it follows strict physical laws, and chaos in these systems leads to increasing disorder unless acted upon by external forces. A storm, for example, forms due to differences in temperature and pressure but does not correct itself; it dissipates only when external conditions stabilize. A malfunctioning machine will not fix itself unless a human or AI intervenes. Economic crises caused by unchecked greed and corruption continue until governments regulate financial imbalances. -/- The only force capable of correcting chaos in non-organic matter is higher intelligence—specifically, human intelligence. Throughout history, human beings have acted as external regulators to restore order in chaotic non-organic systems. For example: ✔ Engineering and technology help control natural forces—dams regulate rivers, satellites predict weather, and medicine counteracts disease. ✔ Governance and laws prevent economic collapse, crime, and war by ensuring that human behavior aligns with sustainable balance. ✔ Environmental conservation corrects imbalances caused by industrialization and pollution, restoring ecosystems to a stable state. -/- The key takeaway from Malicse’s universal formula is that while organic systems can self-adjust, non-organic systems must be externally balanced to prevent collapse. Leaders and decision-makers must recognize when a system needs external correction to prevent unnecessary destruction. -/- However, the misuse of intelligence can also create more chaos instead of balance. When human decisions are driven by ignorance, greed, or false beliefs, they destabilize both organic and non-organic systems. This is why free will must be aligned with the universal law of balance—otherwise, intelligence becomes destructive rather than corrective. -/- 3. The Evolution of Human Consciousness as the Absolute Balancing Mechanism -/- The ability of humans to regulate chaos in both organic and non-organic systems is not accidental—it is the result of the evolution of human consciousness. Unlike lower life forms that operate purely on instinct, human consciousness has expanded to perceive, understand, and control the forces of nature. -/- This evolution can be seen in: ✔ The rise of scientific understanding, where humans learned to decode the natural laws governing both organic and inorganic systems. ✔ The development of ethical and moral reasoning, allowing societies to correct imbalances caused by selfish or destructive behaviors. ✔ The pursuit of wisdom, where human intelligence moves beyond mere survival and actively seeks universal harmony. -/- At its highest stage of evolution, human consciousness becomes the absolute balancing mechanism of the universe. This means that humanity’s ultimate role is not merely to exist but to actively maintain and restore equilibrium across all systems—from biology to technology, from economics to planetary ecosystems. -/- If human intelligence continues to evolve in alignment with the universal law of balance, it will become the guiding force that corrects all chaos—ensuring that free will, governance, and even artificial intelligence function in harmony with natural equilibrium. -/- 4. Implementing the Universal Formula in Education and Governance -/- To correct the current global imbalance, Malicse’s universal formula must be integrated into the educational system. Schools must teach: ✔ The law of balance in nature, helping students understand that all decisions must align with natural laws to prevent chaos. ✔ Critical thinking, ensuring individuals can differentiate between truth, false beliefs, and misinformation. ✔ Holistic governance, training future leaders to manage societies based on natural balance rather than short-term personal gains. -/- Governments, too, must shift from short-term, economically driven policies to long-term, balance-driven policies. Policies should function like biological feedback mechanisms, continuously adjusting to maintain equilibrium. Economic regulations must prevent extreme wealth inequality, environmental policies must preserve natural ecosystems, and social structures must ensure stability without suppressing free will. -/- 5. The Role of AGI in Maintaining Natural Balance -/- A key application of Malicse’s universal formula is in the development of artificial general intelligence (AGI). If AGI is programmed with the law of balance, it can serve as an external regulatory force in areas where non-organic chaos occurs. AGI can: ✔ Monitor and predict economic imbalances, preventing market crashes. ✔ Analyze environmental changes, providing solutions to climate instability. ✔ Detect political instability, offering governance solutions based on natural balance rather than human bias. -/- However, AGI must be guided by evolved human intelligence to ensure it follows natural balance rather than becoming a tool for artificial control. Without this, AGI risks enforcing rigid, unnatural systems that disrupt organic balance rather than restore it. -/- 6. Conclusion: The Universal Formula as the Only Correct Solution -/- Malicse’s universal formula provides the only exact solution to the problem of chaos in both organic and non-organic systems. It highlights that: ✔ Organic systems self-regulate, but only if free will follows natural balance. ✔ Non-organic systems require external regulation, and only higher intelligence (humans) can provide this. ✔ The evolution of human consciousness is the key to balancing all systems, allowing humans to act as the absolute balancing force of the universe. ✔ Education, governance, and AGI must be designed to maintain balance, ensuring stability without suppressing free will. -/- If humanity fails to adopt this approach, chaos will continue to escalate, leading to further suffering, societal collapse, and environmental destruction. The only path forward is to fully integrate the universal formula into all aspects of education, governance, and artificial intelligence. -/- The time to act Is now. -/- . (shrink)

PUERPÉRIO EM BOVINOS -/- INTRODUÇÃO -/- O puerpério é definido como o período entre o parto e a apresentação do primeiro estro fértil. Dois processos ocorrem durante o puerpério: a involução uterina e o início da atividade ovariana pós-parto. Em vacas leiteiras, os cuidados médicos pós-parto são essenciais nos programas de manejo, uma vez que as patologias uterinas são diagnosticadas e tratadas nesse período para que a vaca esteja em ótimas condições para ser inseminada, uma vez terminado o período de (...) espera voluntário. -/- 4.1 Involução uterina -/- O útero após o parto sofre modificações macroscópicas e microscópicas, até atingir as características de um útero não gestante, o que leva de 30 a 45 dias. O peso e o tamanho pós-parto diminuem rapidamente como consequência da atrofia das fibras musculares; por necrose das carúnculas e por eliminação de líquidos. Ao mesmo tempo em que o útero diminui de tamanho, o endométrio passa por um processo regenerativo para poder hospedar uma nova gestação. -/- A involução é promovida pelas contrações uterinas, que facilitam a eliminação de fluidos e dejetos e reduzem o tamanho do útero. As contrações são causadas pela secreção contínua de PGF2α, de origem uterina, e pela ocitocina secretada durante a amamentação. A PGF2α é secretada durante as primeiras 3 semanas pós-parto e seu envolvimento é considerado necessário para que a involução uterina ocorra normalmente. -/- Durante a involução uterina, as secreções conhecidas como lóquios, que são formadas por restos de membranas, carúnculas, fluidos fetais e sangue, são derramadas pela vagina. Essas secreções variam da cor vermelha ao marrom, têm consistência viscosa e são inodoras. A maioria dos lóquios é descartada durante os primeiros 15 dias após o parto e, em seguida, praticamente desaparece, exceto em casos de involução uterina anormal, quando o útero continua a derramar fluidos de consistência, cor e odor diferentes (figura 1). -/- Figura 1: O útero após o parto sofre alterações macroscópicas e microscópicas, até atingir as características de um útero não grávido, o que leva de 30 a 45 dias. -/- Antes do parto, o útero é estéril, pois é protegido da contaminação bacteriana pelo colo do útero ou cérvix. Durante e após o parto, essa barreira física desaparece e o útero é invadido por bactérias que se encontram no meio ambiente, pele e fezes, ou que são introduzidas durante a assistência ao parto. Além disso, a capacidade funcional dos fagócitos uterinos é baixa após o parto, o que contribui para o estabelecimento de infecções. Cerca de 95% das vacas desenvolvem infecções uterinas durante a involução, e uma alta porcentagem de vacas as eliminam por meio de mecanismos naturais. -/- Os mecanismos de defesa uterinos são constituídos pelas barreiras anatômicas (vagina, vulva e cérvix); fatores fisiológicos (produção de muco na vagina e cérvix); fagocitose promovida por neutrófilos, que migram da circulação geral para o útero; pela produção de substâncias inespecíficas, que inibem o crescimento bacteriano e favorecem a eliminação de microrganismos. A capacidade de eliminar bactérias do útero é determinada pelos hormônios ovarianos (progesterona e estrogênios); durante o diestro, a progesterona reduz a migração de neutrófilos, suprime o sistema imunocompetente, fecha o colo do útero e causa atonia uterina, resultando em aumento da suscetibilidade à infecção. Ao contrário, durante a fase folicular do ciclo estral (proestro e estro), o estradiol promove a migração de neutrófilos, abre a cérvix e aumenta o tônus uterino, o que facilita a eliminação de agentes infecciosos. Além disso, a atividade dos neutrófilos é afetada pelas deficiências antioxidantes e pela profundidade do balanço energético negativo. -/- 4.2 Anormalidades do puerpério -/- Após o parto, ocorrem algumas patologias que retardam a involução uterina e, consequentemente, afetam o intervalo entre o parto e o primeiro serviço. -/- 4.2.1 Retenção da placenta -/- A placenta é eliminada dentro de 12 horas após o parto; a retenção da placenta por mais de 24 horas é considerada uma patologia. A retenção placentária (RP) é uma alteração frequente do puerpério, que deve ser considerada como um sinal clínico de várias condições que podem ter origem infecciosa (aborto), metabólica (hipocalcemia, cetose, síndrome do vaca gorda), deficiências nutricionais (selênio e vitamina E) e erros de manejo (demasiada intervenção no parto). -/- A incidência de RP varia de 5 a 15% e depende, em grande parte, do estado de saúde e do manejo do rebanho. A RP é o principal fator de risco para infecções uterinas (metrite puerperal, metrite, endometrite e endometrite subclínica); também causa atraso no período entre o parto e a concepção e está associada à redução do percentual de concepção no primeiro serviço. -/- Em termos econômicos, determinou-se que a RP causa perdas significativas principalmente devido aos custos de serviços médicos, aumento da taxa de eliminação e diminuição da fecundidade. Além disso, vacas com retenção placentária produzem 355 kg a menos de leite durante os primeiros 60 dias do que vacas que não apresentam esta patologia (figuras 2 e 3). -/- 4.2.2 Patogenia -/- A placenta está ligada ao endométrio pelas vilosidades coriônicas, que estão ligadas às carúnculas (junção carúncula-cotilédone). A união entre essas estruturas é favorecida por um fluido adesivo formado por colágeno e outras proteínas. Antes e durante o trabalho de parto, observa-se um aumento da atividade das enzimas proteolíticas (colagenase, talvez a mais importante), que são responsáveis por separar o cotilédone da carúncula. Posteriormente, a placenta é removida mecanicamente por contrações uterinas após o parto do feto. -/- A etiologia e patogênese da retenção placentária não são conhecidas. Uma explicação proposta é que isso se deve a uma falha dos mecanismos proteolíticos responsáveis pela separação do cotilédone da carúncula. Foi observado que a atividade da colagenase no cotilédone é maior em vacas que não retêm placenta do que naquelas que a retêm. Propõe-se que alguns fatores de risco para retenção placentária possam estar atuando na redução da atividade da colagenase. Por outro lado, as condições inflamatórias na junção carúncula-cotilédone de origem infecciosa também impedem a separação da placenta. -/- Figura 3: Vaca com retenção placentária. -/- Figura 2: Vaca com retenção placentária. Em rebanhos comerciais, 5 a 15% das vacas retêm a placenta. -/- 4.2.3 Tratamento -/- Existem vários tratamentos, como a remoção manual da placenta em combinação com a aplicação local de antibióticos (infusões intrauterinas) e a administração de produtos hormonais (ocitócicos e PGF2α). A eficácia desses tratamentos é discutível. -/- A remoção manual da placenta é o tratamento mais popular; entretanto, não é a melhor, pois causa danos ao endométrio, que variam de leve sangramento a hematomas, mesmo quando não há evidências externas. Além disso, a remoção manual diminui a capacidade fagocítica dos leucócitos uterinos, resultando em metrite mais grave, maior atraso na involução uterina e baixo desempenho reprodutivo. -/- Outro tratamento consiste em cortar a placenta ao nível da vulva. Posteriormente, quando a placenta se separa das carúnculas, devido ao processo de decomposição do tecido, uma leve tração da vulva é suficiente para retirá-la, sem consequências. Essas vacas devem ser observadas quanto à febre e imediatamente integradas ao programa de check-up pós-parto, pois certamente desenvolverão metrite ou endometrite. A administração de antibióticos, tanto nos casos de retirada manual como naqueles em que a placenta é cortada, depende do estado geral da vaca. Deve-se sempre ter em mente que a RP é o principal fator de risco para metrite, portanto as vacas devem ser observadas para detectar prontamente aquelas que apresentam febre. Os antibióticos devem ser considerados para inibir a putrefação das membranas fetais, o que pode atrasar sua expulsão. No caso de opção pela administração de antibióticos, deve-se optar pela via parenteral em vez da intrauterina, pois esta causa irritação do endométrio, que está associada à baixa fertilidade (figura 4). -/- Outros tratamentos são baseados na administração de hormônios que estimulam a mobilidade uterina (ocitocina, estrogênios e PGF2α); entretanto, não há evidências clínicas que demonstrem sua eficácia; além disso, a causa menos frequente de RP é a incapacidade mecânica do útero de expelir a placenta. -/- 4.2.4 Prevenção -/- As estratégias de prevenção dessa patologia devem ter como objetivo reduzir a influência dos fatores de risco para RP. Assim, a incidência de abortos deve ser reduzida por meio de programas eficazes de vacinação e biossegurança; deve-se evitar períodos de seca muito longos para que as vacas não cheguem obesas ao parto; intervir o mínimo possível nos partos, e se atendido, deve ser feito com medidas de higiene rígidas; oferecer sais minerais de boa qualidade e administrar antioxidantes antes do parto (vitamina E, selênio e betacarotenos; tabela 1). -/- Figura 4: A placenta não deve ser removida inserindo a mão na vagina. É aconselhável aguardar a autólise (48 horas) e removê-la por leve tração. -/- Tabela 1: Incidência de retenção na membrana fetal (RMF), metrite hemorrágica (HM), metrite purulenta (PM) e puerpério anormal (PA) em vacas leiteiras tratadas com selênio e vitamina E nos dias 60, 21 antes do parto e 30, 90 pós-parto (grupo pré-pós-parto) e 21 dias pré-parto (grupo pré-parto) e testemunhas. -/- Laterais diferentes na mesma coluna indicam diferença estatística (P < 0,05). Adaptado de RUIZ et al., 2008. -/- 4.3 Infecções uterinas -/- Cerca de 95% das vacas desenvolvem infecção uterina durante os primeiros dias pós-parto; no entanto, a maioria elimina infecções por meio de seus mecanismos de defesa e apenas 30 a 50% delas desenvolvem metrite ou endometrite nas primeiras três semanas. As bactérias mais frequentes encontradas em processos inflamatórios no útero são: Arcanobacterium pyogenes (antes Actinomyces pyogenes), Fusobacterium necrophorum e Escherichia coli. Essas três bactérias agem sinergicamente. -/- 4.3.1 Metrite puerperal -/- A metrite puerperal é comum em vacas com retenção placentária. Essa patologia é observada nas três primeiras semanas pós-parto e é caracterizada pela presença de secreções abundantes na luz uterina que são vermelhas ou marrons, aquosas, fétidas e com involução retardada. As vacas afetadas mostram sinais de doença sistêmica (toxemia e febre > 39,5 °C) e diminuição da produção de leite (figura 5). -/- Figura 5: Vaca com metrite puerperal; vacas afetadas apresentam sinais de doença sistêmica. -/- 4.3.2 Metrite clínica -/- Metrite é o processo inflamatório que envolve as diferentes camadas do útero (mucosa, muscular e serosa). Esta condição se apresenta nos primeiros 21 dias pós-parto e é caracterizada por atraso na involução uterina e secreção purulenta, e não há sinais de doença sistêmica (figura 6). -/- 4.3.3 Endometrite clínica -/- Endometrite se refere à inflamação do revestimento uterino; clinicamente, caracteriza-se por retardo na involução uterina e eliminação de exsudato purulento ou mucopurulento. Pode surgir nos primeiros 21 dias pós-parto ou mais, sem apresentar qualquer afetação no estado geral. -/- Figura 6: Vaca com exsudato mucopurulento. Na prática, é difícil estabelecer um diagnóstico diferencial entre endometrite e metrite. Uma vaca com essa secreção pode ser tratada com cefalosporinas intrauterinas ou, se ela já estiver em ciclo, a administração de PGF2a é eficaz. -/- 4.3.4 Endometrite subclínica -/- Apresenta-se entre 21 e 40 dias pós-parto, não apresenta sinais externos e só é diagnosticada pela citologia uterina. Essa condição afeta entre 20 e 30% das vacas. Os fatores de risco identificados são retenção placentária e metrite. -/- 4.4 Diagnóstico -/- O diagnóstico é baseado na avaliação uterina por palpação retal, na qual são verificados o grau de involução e as características das secreções. Além disso, é necessária uma avaliação clínica geral, uma vez que vacas com metrite nos primeiros 10 dias pós-parto desenvolvem febre. Outra forma de estabelecer o diagnóstico é avaliando as secreções uterinas sem palpação retal. Pode ser feito introduzindo a mão por via vaginal, após a limpeza da região; embora este método possa parecer arriscado, a experiência em campo indica que é um método seguro e rápido. Outra possibilidade é por meio da vaginoscopia, esse método permite a avaliação da cérvix e das secreções uterinas. Existe um instrumento (Metricheck) que é inserido pela vagina e possui uma campânula atraumática na extremidade que permite a coleta das secreções uterinas (figuras 7 e 8). -/- 4.5 Impacto das infecções uterinas na reprodução e produção -/- As infecções uterinas (metrite e endometrite) prolongam o período do parto até a concepção; diminuem a porcentagem de concepção no primeiro serviço; a porcentagem de resíduos aumenta; a taxa de vacas inseminadas diminui e a produção diminui (300 kg a menos que vacas não afetadas). Além disso, eles afetam o período do parto à primeira ovulação; em vacas com puerpério anormal, os folículos dominantes são menores em diâmetro e produzem menos estradiol do que vacas saudáveis. Também uma proporção menor dos folículos da primeira onda ovula em comparação com as vacas com puerpério anormal. -/- A endometrite subclínica diminui a taxa de concepção no primeiro serviço e aumenta os dias abertos. Além disso, a metrite ou endometrite pode afetar os ovidutos e causar inchaço, obstrução e aderências (esse processo é mais frequente em vacas que recebem injeções de estrogênio). -/- Figura 8: Outra forma de diagnosticar infecções uterinas é por meio da introdução de um instrumento que possui em sua extremidade uma campânula atraumática que permite a coleta de secreções uterinas (Metricheck). -/- Figura 7: O diagnóstico de infecções uterinas pode ser estabelecido com a introdução da mão por via vaginal, após limpeza da região. -/- 4.6 Tratamentos -/- Para evitar o efeito negativo das infecções uterinas na eficiência reprodutiva, é necessário um diagnóstico e tratamento oportunos. Existem diversos tratamentos para a metrite ou endometrite, como o uso de antibióticos sistêmicos ou intrauterinos, infusões intrauterinas de antissépticos e a administração de hormônios. -/- 4.6.1 Antibióticos -/- Os tratamentos com antibióticos intrauterinos são usados há muitos anos e são uma opção, desde que alguns aspectos sejam considerados: que o útero é um ambiente anaeróbio; que há a presença de exsudatos e tecidos em decomposição e a existência de uma grande diversidade de bactérias, algumas das quais até produzem enzimas que inativam alguns antibióticos. -/- Como o útero é um ambiente anaeróbio, os antibióticos do grupo dos aminoglicosídeos não são ativos, pois precisam de oxigênio. Por outro lado, o acúmulo de exsudato purulento e restos de tecido no útero inibe a atividade das sulfonamidas. Os nitrofuranos são eficazes contra A pyogenes, somente quando doses extremamente altas são usadas; as doses usuais nunca atingem a concentração inibitória mínima no endométrio; além disso, não são ativos na presença de sangue ou exsudato purulento, são irritantes e estão associados a problemas de fertilidade. -/- A penicilina intrauterina ou parenteral é eficaz na cura de infecções entre os dias 25 e 30 após o parto; ou seja, quando for observada uma diminuição na diversidade de espécies bacterianas (menor probabilidade de que algumas bactérias produzam penicilinase) e predomina A pyogenes, que é sensível a este antibiótico. As formulações intrauterinas de cefalosporinas (cefapirina benzatina) são eficazes em vacas com endometrite entre os dias 15-20 pós-parto e não é necessário retirar o leite do mercado. -/- A tetraciclina é o antibiótico mais utilizado devido ao seu amplo espectro e por manter sua atividade nas condições do útero pós-parto; porém, a probabilidade de resistência bacteriana é alta devido ao seu uso contínuo por muitos anos, também causa danos ao endométrio e reduz a fertilidade (figura 9). -/- Em testes de campo, a administração de uma única infusão intrauterina de cefapirina benzatina, em vacas com endometrite entre os dias 15 a 20 pós-parto, produz uma maior taxa de recuperação e não afeta a fertilidade, em comparação com aquelas que foram tratadas com infusões de oxitetraciclina. -/- O problema mais importante na terapia com antibióticos é estabelecer um critério de quais animais realmente precisam. Nos casos de metrite puerperal não há dúvida, essas vacas precisam de tratamento com antibióticos por via sistêmica e intrauterina. Porém, em casos de metrite e endometrite a decisão é difícil, pois muitas vacas se curam sem nenhum tratamento. Na prática, antes que os antibióticos sejam administrados às vacas, deve-se considerar alguns dos fatores: características das secreções uterinas, dias após o parto, início da atividade ovariana, presença de febre e condição corporal. -/- Figura 9: As infusões de oxitetraciclina causam irritação do endométrio e diminuem a fertilidade. -/- 4.6.2 Tratamento com infusões de substâncias antissépticas -/- Tratamentos baseados na administração intrauterina de substâncias antissépticas também são usados. O tratamento mais frequente consiste na infusão de soluções de iodo; no entanto, os resultados com esta terapia não são positivos e estão associados a uma diminuição subsequente da fertilidade. Deve-se ter cautela no uso de antissépticos intrauterinos, pois todos causam irritação, afetam os mecanismos de defesa do útero e, em alguns casos, chegam a causar necrose do endométrio. -/- 4.6.3 Tratamentos hormonais -/- Na prática, a administração de estrogênio é comum em casos de metrite, principalmente quando o útero retém muito líquido. Sabe-se que os estrógenos em condições fisiológicas favorecem a contratilidade uterina e auxiliam na eliminação de infecções, porém, em doses farmacológicas o efeito é negativo. A administração de estrogênios pode contribuir para infecções que ascendem aos ovidutos e causam salpingite, aderências ovarianas e infertilidade. -/- A PGF2α desempenha um papel importante no parto e durante a involução uterina. Em vacas com puerpério normal, a duração dos níveis elevados de PGF2α está negativamente correlacionada com o tempo de involução uterina; portanto, quanto mais tempo duram os níveis elevados de PGF2α, menor é o tempo de involução uterina. Além disso, a administração de PGF2α a cada 12 horas, dos dias 3 a 10 pós-parto, encurta o período de involução uterina. Ao contrário, em vacas com puerpério anormal, foi observada uma correlação positiva entre as concentrações de PGF2α e o tempo de involução uterina; portanto, vacas com retenção placentária ou endometrite apresentam níveis mais elevados de PGF2α. -/- Algumas evidências envolvem a PGF2α como parte do mecanismo de eliminação da placenta; ou seja, foi observado que as vacas que normalmente eliminam a placenta apresentaram maiores concentrações de PGF2α na placenta, em comparação com as vacas com retenção placentária. Foi proposto que a falha do processo que leva à separação do cotilédone da carúncula está associada a uma alteração no metabolismo da prostaglandina, resultando em uma diminuição na PGF2α e um aumento na PGE2. Por outro lado, a inibição da síntese de PGF2α após o parto, por meio da injeção de ácido acetilsalicílico (aspirina), causa retenção da placenta. Esse conhecimento motivou estudos nos quais o tratamento com PGF2α após o parto foi avaliado para prevenir a retenção placentária ou reduzir o tempo de involução em vacas com retenção placentária ou metrite. Em alguns estudos, uma única injeção de PGF2α foi administrada nas primeiras horas após o parto com resultados conflitantes. Em outros estudos, a injeção de PGF2α entre os dias 20 a 30 pós-parto foi avaliada e não foi observado um efeito favorável na involução uterina. Porém, a injeção sistemática de PGF2α, a cada 14 dias a partir do 25º dia pós-parto, aumenta a proporção de vacas inseminadas, o que aumenta a taxa de prenhez. A PGF2α causa contrações uterinas e favorece a eliminação de secreções; entretanto, um efeito favorável da PGF2α na involução uterina, sem envolver um corpo lúteo, é questionável. -/- Na prática, um programa é usado com base na administração sistemática de PGF2α a todas as vacas a cada 14 dias, do 25º ao 30º dia pós-parto. Esse tratamento é baseado no encurtamento das fases lúteas, o que favorece a eliminação das infecções. Deve-se observar que cerca de 30% das vacas desenvolvem corpos lúteos longevos (21 a 50 dias) nos primeiros ciclos pós-parto, nessas condições a injeção de PGF2α, a cada 14 dias, encurta o ciclo estral e diminui o risco de persistência de infecções uterinas. -/- 4.7 Piometra -/- Esta patologia se desenvolve em vacas que ovulam nos primeiros 20 dias pós-parto e, concomitantemente, sofrem de infecção uterina. Nessas condições, a progesterona promove a proliferação bacteriana e fecha o colo do útero, causando acúmulo de exsudato purulento no útero. As alterações causadas no endométrio alteram a secreção de PGF2α, resultando na persistência do corpo lúteo e anestro. Vacas com piometra respondem muito bem ao tratamento com PGF2α; uma segunda injeção desse hormônio, 14 dias depois, encurta o período de recuperação (figura 10). -/- Figura 10: A piometra é caracterizada pelo acúmulo de exsudato purulento no útero, colo uterino fechado e presença de corpo lúteo. O diagnóstico é feito por palpação retal e tratado com PGF2α. -/- 4.8 Vaginite em fêmeas gestantes -/- A vaginite em fêmeas grávidas ocorre com baixa frequência; porém, quando há um caso, causa alarme porque é confundido com um aborto. Nesses casos, o veterinário deve fazer um exame retal para determinar se o produto está vivo e se a cérvix está aberta. O diagnóstico é concluído com o exame vaginal com vaginoscópio ou diretamente à mão com luva limpa. -/- No caso de um aborto, o produto geralmente está morto e a cérvix está aberta; nestes casos, o produto deve ser extraído. Ao contrário, se a cérvix estiver fechada e o feto estiver vivo, o prognóstico é favorável e o problema diminui com o tratamento com antibióticos sistêmicos. -/- RESUMO -/- < >O útero após o parto pesa 13 kg e no dia 21 pós-parto, 1 kg. A regeneração do epitélio uterino leva 25 dias. A regeneração das camadas profundas do endométrio leva 42 a 56 dias. 95% das vacas desenvolvem alguma infecção uterina. 30 a 50% das vacas desenvolvem metrite nas primeiras duas semanas após o parto. 15 a 20% persistem como endometrite clínica > 3 semanas após o parto. 18 a 20% têm metrite com efeitos sistêmicos. 20 a 30% das vacas têm endometrite subclínica. 5 a 15% das vacas retêm a placenta. 355 kg de leite são perdidos em vacas com retenção placentária. Em vacas que sofrem de puerpério anormal, a proporção de vacas prenhes é reduzida em 10 por cento no 90º dia pós-parto. No Reino Unido, 192 euros são gastos por cada vaca que tem um puerpério anormal. REFERÊNCIAS BIBLIOGRÁFICAS -/- ANDREWS, Anthony H. et al. (Ed.). Bovine medicine: diseases and husbandry of cattle. John Wiley & Sons, 2008. -/- AZAWI, O. I. Postpartum uterine infection in cattle. Animal reproduction science, v. 105, n. 3-4, p. 187-208, 2008. -/- BEARDEN, Henry Joe et al. Applied animal reproduction. Reston Publishing Company, Inc., 1984. -/- HOLY, Lubos; MARTÍNEZ JÚSTIZ, G. Colab. Biología de la reproducción bovina. Havana: Revolucionária, 1975. -/- HOPPER, Richard M. (Ed.). Bovine reproduction. John Wiley & Sons, 2014. -/- HORTA, António Eduardo Monteiro. Fisiologia do puerpério na vaca. Jornada Internales de Reproductión Animal, v. 8, p. 73-84, 1995. -/- KOZICKI, Luiz Ernandes. Aspectos fisiológicos e patológicos do puerpério em bovinos. Archives of Veterinary Science, v. 3, n. 1, 1998. -/- LEBLANC, S. J. et al. Defining and diagnosing postpartum clinical endometritis and its impact on reproductive performance in dairy cows. Journal of dairy science, v. 85, n. 9, p. 2223-2236, 2002. -/- LEBLANC, S. J. et al. The effect of treatment of clinical endometritis on reproductive performance in dairy cows. Journal of dairy science, v. 85, n. 9, p. 2237-2249, 2002. -/- MARTINS, T. M.; BORGES, A. M. Avaliação uterina em vacas durante o puerpério. Rev. Bras. Reprod. Anim, Belo Horizonte, v. 35, n. 4, p. 433-443, 2011. -/- RADOSTITS, Otto M. et al. Clínica Veterinária: um tratado de doenças dos bovinos, ovinos, suínos, caprinos e eqüinos. Rio de Janeiro: Guanabara Koogan, 2002. -/- RISCO, CARLOS A.; YOUNGQUIST, ROBERT S.; SHORE, M. DAWN. Postpartum uterine infections. In: Current therapy in large animal theriogenology. WB Saunders, 2007. p. 339-344. -/- SHELDON, I. M. et al. Influence of uterine bacterial contamination after parturition on ovarian dominant follicle selection and follicle growth and function in cattle. REPRODUCTION-CAMBRIDGE-, v. 123, n. 6, p. 837-845, 2002. -/- SHELDON, I. M. et al. Mechanisms of infertility associated with clinical and subclinical endometritis in high producing dairy cattle. Reproduction in domestic animals, v. 44, p. 1-9, 2009. -/- SHELDON, I. Martin et al. Uterine diseases in cattle after parturition. The Veterinary Journal, v. 176, n. 1, p. 115-121, 2008. -/- TIXI, C. et al. Factores que afectan el porcentaje de vacas gestantes en el día 90 posparto. In: Memorias del XXXIII Congreso Nacional de Buiatría. Tuxtla Gutiérrez Chiapas. México. pp. 2009. (shrink)

Ignorance as the Root Cause of All Human and Societal Problems -/- Throughout history, humanity has struggled with a wide range of issues, from poverty and war to corruption and environmental destruction. While these problems may seem complex and varied, they all share a common root cause: ignorance. Ignorance, defined as a lack of knowledge, awareness, or understanding, is the fundamental source of poor decision-making, social injustice, and systemic failures. It is the invisible force that allows harmful ideologies to persist, (...) enables exploitation by those in power, and prevents societies from achieving sustainable progress. Unless ignorance is addressed through a holistic educational approach, humanity will continue to suffer from the same recurring problems. -/- The Consequences of Ignorance -/- 1. Poor Decision-Making and Its Societal Impact -/- Ignorance leads individuals and leaders to make uninformed or irrational decisions. When people lack knowledge about critical subjects—such as economics, science, health, or governance—they are more likely to make choices that harm themselves and others. For instance, ignoring the scientific evidence behind climate change has resulted in environmental destruction, worsening natural disasters, and resource scarcity. Similarly, uninformed political decisions can lead to economic crises, social unrest, and ineffective policies that fail to address the real needs of the people. -/- 2. Manipulation and Exploitation of the Masses -/- A population that is unaware of its rights and the mechanisms of power is easily manipulated by politicians, corporations, and religious institutions. Ignorance allows corruption to thrive, as people may be unaware of the deceitful tactics used by leaders who prioritize personal gain over public welfare. For example, authoritarian regimes often exploit the ignorance of their citizens by spreading propaganda, suppressing dissent, and maintaining a false sense of national progress. Without critical thinking skills, people fall victim to misinformation, fake news, and ideological manipulation. -/- 3. Religious and Ideological Conflicts -/- History is filled with wars and conflicts rooted in religious and ideological ignorance. When individuals blindly follow dogma without questioning its validity or understanding different perspectives, intolerance and discrimination arise. Religious extremism, racial discrimination, and cultural biases are often fueled by a lack of knowledge about diversity and human unity. Ignorance fosters division among people, making it difficult to achieve peace and cooperation in society. -/- 4. Resistance to Change and Innovation -/- Ignorance creates fear of the unknown, leading societies to resist progress. Scientific discoveries and technological advancements often face opposition because people do not understand them or perceive them as threats to tradition. For example, when the printing press was invented, religious authorities opposed it because it allowed the spread of knowledge that challenged established doctrines. Today, the same resistance can be seen in debates over artificial intelligence, renewable energy, and other innovations that could improve human life but are hindered by fear and misinformation. -/- 5. Social Injustice and Discrimination -/- Ignorance perpetuates social inequalities, as people fail to recognize systemic injustices and their own biases. Racism, sexism, and class discrimination are all products of misunderstanding and misinformation. When people are unaware of the historical and social structures that create inequality, they are less likely to support policies that promote fairness and human rights. Education plays a crucial role in breaking down prejudices and fostering a more just society. -/- 6. Economic Inequality and Poverty -/- Many people remain trapped in poverty due to a lack of financial education and economic literacy. Ignorance about personal finance, investment, and economic systems prevents individuals from making informed decisions that could improve their lives. On a larger scale, nations with poorly educated populations struggle to develop sustainable economies, as corruption, mismanagement, and short-term thinking hinder progress. When citizens understand economic principles, they can demand better governance and policies that promote prosperity for all. -/- 7. Health Crises and Misinformation -/- A lack of knowledge about health and medicine leads to preventable diseases and unnecessary deaths. The COVID-19 pandemic, for example, highlighted how misinformation about vaccines and treatments contributed to the spread of the virus. Ignorance about basic hygiene, nutrition, and medical science continues to be a major problem in many parts of the world. Proper education can empower individuals to take control of their health and make informed decisions that benefit society as a whole. -/- 8. Environmental Destruction -/- Ignorance about ecological balance and sustainability has led to reckless exploitation of natural resources, deforestation, pollution, and climate change. Many people do not understand the long-term consequences of their actions on the environment, resulting in irreversible damage to ecosystems. A well-informed society would prioritize sustainable living and conservation efforts to ensure the survival of future generations. -/- The Solution: A Holistic Educational System -/- To address ignorance at its root, a holistic educational system must be implemented. This system should emphasize: -/- ✅ Critical Thinking and Scientific Literacy – Teaching individuals to analyze information, recognize misinformation, and make rational decisions. ✅ The Universal Law of Balance in Nature – Educating people about how all systems must maintain equilibrium to function effectively, reducing ignorance-driven societal imbalances. ✅ Ethical Decision-Making and Governance – Training future leaders to prioritize balance and sustainability over greed and short-term gains. ✅ Artificial Intelligence and Technology Awareness – Preparing society for technological advancements to prevent exploitation and misuse. ✅ Cultural and Religious Compatibility – Ensuring that education respects religious beliefs while promoting rational and evidence-based thinking. -/- Conclusion -/- Ignorance is the invisible force that fuels human suffering, injustice, and societal collapse. Whether it manifests in poor decision-making, manipulation, resistance to progress, or environmental destruction, its consequences are undeniable. However, ignorance is not an unsolvable problem—it can be eradicated through proper education. A holistic educational system that integrates critical thinking, scientific literacy, and the universal law of balance in nature can empower individuals to make informed choices and build a more just, intelligent, and sustainable society. By addressing ignorance at its core, humanity can finally break free from the cycle of suffering and progress toward a future of true enlightenment and balance. -/- . (shrink)

Located within the ascending reticular activating system are nuclei which release neurotransmitters such as acetylcholine, serotonin, dopamine, and norepinephrine. These nuclei have widespread projections that extend into the limbic system and throughout cortex. Activation of these neurotransmitters during awake states leads to arousal, while inhibition leads to the loss of consciousness experienced during slow-wave sleep. Previously, we proposed a mechanism in which cardiorespiratory synchronization may underlie the widespread hyperpolarization that occurs throughout the brain during slow-wave sleep. We further propose that (...) a similar homeostatic mechanism may be involved in sleep-wake transitions and maintaining various arousal states including rapid eye movement sleep, waking, and anxiety. Widespread depolarization associated with more rapid, shallow breathing and desynchronized cardiorespiratory oscillatory activity may underlie waking, anxiety, and rapid eye movement sleep states. The exact voltage values of these widespread membrane potential changes remain unknown and possibly highly variable between different neural areas and cell types. Here, we place these consciousness states on a spectrum of approximated widespread membrane potential values with anxiety states being the most depolarized, followed by waking states, and rapid eye movement sleep. We propose that although these widespread membrane potential changes are minor, they may underlie transitions between and maintenance of varying levels of arousal. Further research on these mechanisms could provide insights into how the brain functions. This homeodynamic arousal mechanism involves the established feed-forward and feedback signaling between the ascending reticular activating system and the hypothalamus, as well as the modulation by cardiorespiratory oscillatory feedback from the body. Understanding the basic mechanisms responsible for the states of sleep, waking, and anxiety could lead to better treatment options in health and disease. (shrink)

This article describes a case of a ’spiritual attack’ in the context of Amazonian ayahuasca ceremonies. These attacks are often assumed to be imaginary, and there is relatively little information available about them. Specifically, there appears to be no documentation about possible mechanisms of action for these attacks. Subjectively, they typically appear as context-dependent visions or somatic sensations that represent disease-inducing or lethal interventions from an external hostile party. -/- Such ’spiritual attacks’ could tentatively be conceptualized as subjective (...) mental representations of fundamental disagreements between two parties. ’Defenses’ against these attacks might then consist of methods for maintaining stability and resolving the associated negative affects. This discussion could facilitate an improved understanding of this rarely documented, difficult-to-conceptualize phenomenon. -/- doi: 10.13140/RG.2.2.11914.34247. (shrink)