Claims that our species is an “evolutionary success” typically do not feature prominently in academic articles. However, they do seem to be a recurring trope in science popularization. Why do we seem to be attracted to viewing human evolution through the lense of “success”? In this chapter we discuss how evolutionary success has both causal-descriptive and ethical-normative components, and how its ethical status is ambiguous, with possible hints of anthropocentrism. We also place the concept of “success” in a wider context (...) of biological thought, contrasting it with two other value-laden concepts: evolutionary progress and human uniqueness. Claiming the human species to be an evolutionary success is ostensibly grounded in metrics such as the dominance or the size of the human population, but often goes beyond this, suggesting that humans are a unique species or the pinnacle of evolutionary progress. (shrink)

One of the aims of the encyclical "Laudato Si’" is to help us “marvel at the manifold connections existing among creatures”, to show how we are also involved, and to motivate us thereby to care for our common home. Are there new dimensions of beauty available to us today because of recent advances in biology? In this paper I seek to answer this question by first recalling the basic criteria for beauty, as expressed by Aristotle and Aquinas, and then (...) evaluating their applicability as regards three ways in which some prominent twentieth century philosophers of biology have sought to overcome the limitations of reductionism. The overall argument refers especially to the works of Jakob von Uexküll and Georges Canguilhem. The results indicate that harmony, proportion, and integrity in the natural order should be more evident than ever before, especially as regards the way the organism and its environment codetermine each other. This insight allows a deeper appreciation of the message of "Laudato Si’". (shrink)

This study purports a unifying view of the ontology of mathematics and fiction presented in Husserl’s 1894 manuscript “Intentional Objects” [Intentionale Gegenstände] in relation to his theory of manifolds. In particular, I clarify that Husserl’s argument supposes deductive systems of mathematical theories and fictional work as well as their “correlates,” which are mathematical manifolds in the former cases. This unifying view concretizes the concept of manifolds as an ontological concept that is not bound to mathematics. Although mathematical and fictional objects (...) differ in whether they are purely formal or materially filled, the concept of manifolds can be extended to admit materially filled objects, thus encompassing the two into the unitary theory of manifolds. By contrast, reviewing the subsequent developments of Husserl’s theory of manifolds naturally leads to restricting its concept to be strictly formal. This notion is consistent with the view that describes manifolds as forms of worlds and states of affairs; however, I suggest that the concept of the manifold is more fundamental than the concept of the world and state of affairs. (shrink)

We discuss central aspects of history of the concept of an affine differentiable manifold, as a proposal confirming the need for using some quantitative methods (drawn from elementary Model Theory) in Mathematical Historiography. In particular, we prove that this geometric structure is a syntactic rigid designator in the sense of Kripke-Putnam.

Husserl’s theory of manifolds was developed for the first time in a very short form in the Prolegomena to his Logical Investigations, §§ 69–70 (pp. 248–53), then repeatedly discussed in Ideas I, §§ 71–2 (pp. 148–53), in Formal and Transcendental Logic, §§ 51–4 (pp. 142–54), and finally in the Crisis, § 9 (pp. 20–60). Husserl never lost sight of it: it was his idée fixe. He discussed this theme over forty years, expressing the same, in principle, ideas on it in (...) different terms and versions. His discussions of it, however, were always cut short and inconclusive, so that he never developed his theory of manifolds in detail. Main claim in this essay is that Husserl’s theory of manifolds is twofold. It is (1) a theory of theories, advanced in the good German tradition of Wissenschaftslehre, launched first by Bernard Bolzano. The latter, in turn, is an offspring of the ancient tradition of mathesis universalis, explored in the modernity by Descartes and Leibniz. Further, (2) the theory of manifolds is also a formal theory of everything. Its objective is to provide a systematic account of how the things in the world (its parts) hang together in wholes of quite different kind. It is to be noted that Husserl explicitly speaks about (1) and only implicitly about (2). In this paper we shall also show that the theory of everything is intrinsically connected with the theory of theories. (shrink)

My journey as a teacher started in 1971, keeping the student's interests in mind. The experiences gained through observing some of the best teachers in mind like Dr. Gopalan (Director General of ICMR) Dr. Srikantia (Director, National Institute of Nutrition, Hyderabad), and Dr. Copper (Madras Medical College) I developed an interest in teaching. What I learned was to teach in a simple language that is relevant to the field of education. Being a Rotarian as well as having the opportunity of (...) being a Student Advisory Council chairman, IISc, Banglore, and Ad Hoc President of the Research Scholar’s Association, Madras University, I learned the art of speaking and communication. One of the key points of my learning is to learn the ability to develop a rapport with the students whom I teach. The workshops and training imparted by Medical Education Nodal centers, refined and made my teaching relevant to medical students. One of the most important requirements is to have practical skills that help you to adapt your teaching to the needs of the students. I developed this skill as I ran one of the ICMR-recognized diagnostic centers. The center gave me the opportunity to gain my practical skills for basic and clinical Biochemistry. (shrink)

A relatively unknown woman named Maria Theresa Short opened a popular observatory in 1835 in Ed inburgh - a time and place where men of science and property had long failed to make a viable space for astronomy. She exhibited scientific instruments to a general public, along with a great telescope and a walk-in camera obscura that projected live views of the city and continues to delight audiences to this day. To better understand Short's accomplishments, achieved as scientific and (...) public life became increasingly closed to women, this study explores her largely untold story, and maps some of the places of science around it. Finding local contingencies, multiple sites and practices by diverse groups, it proposes that tensions within the connections between science and spectacle and the use of popularization to promote its professionalization produced gaps that even a marginal figure like Maria Short could inhabit and exploit. (shrink)

Does inner sense, like outer sense, provide inner sensations or, in other words, a sensory manifold of its own? Advocates of the disparity thesis on inner and outer sense claim that it does not. This interpretation, which is dominant in the preexisting literature, leads to several inconsistencies when applied to Kant’s doctrine of inner experience. Yet, while so, the parity thesis, which is the contrasting view, is also unable to provide a convincing interpretation of inner sensations. In this paper, (...) I argue that this deadlock can be traced back to an inadequate understanding of inner sense shared by both sides. Drawing upon an analysis of the notion of obscure representations, I offer an alternative interpretation of inner sense with a special regard to self-affection, apprehension, and attention. From this basis, I will infer that outer sense delivers sensory content that is initially and intrinsically unaccompanied by phenomenal consciousness; inner sense contributes by endowing such content with phenomenal consciousness. Therefore, phenomenal qualities can be regarded as the sensory manifold of inner sense. This alternative interpretation solves the long-standing dispute concerning inner sensations and would further illuminate Kant’s notion of inner experience. (shrink)

This paper proposes a new classification algorithm for the partitioning of a conceptual space. All the algorithms which have been used until now have mostly been based on the theory of Voronoi diagrams. This paper proposes an approach based on potential theory, with the criteria for measuring similarities between objects in the conceptual space being based on the Newtonian potential function. The notion of a fuzzy prototype, which generalizes the previous definition of a prototype, is introduced. Furthermore, the necessary conditions (...) that a natural concept must meet are discussed. Instead of convexity, as proposed by Gärdenfors, the notion of geodesically convex sets is used. Thus, if a concept corresponds to a set which is geodesically convex, it is a natural concept. This definition applies, for example, if the conceptual space is an Euclidean space. As a by-product of the construction of the algorithm, an extension of the conceptual space to d-dimensional Riemannian manifolds is obtained. (shrink)

Cross-cultural comparisons face several methodological challenges. In an attempt at resolving some such challenges, Nathan Sivin has developed the framework of “cultural manifolds.” This framework includes all the pertinent dimensions of a complex phenomenon and the interactions that make all of these aspects into a single whole. In engaging with this framework, Anna Akasoy illustrates that the phenomena used in comparative approaches to cultural and intellectual history need to be subjected to a continuous change of perspectives. Writing about comparative history, (...) Warwick Anderson directs attention to an articulation between synchronic and diachronic modes of inquiry. In addition, he asks: If comparative studies require a number of collaborators, how does one coordinate the various contributors? And how does one ensure that the comparison is between separate entities, without mutual historical entanglement? Finally, how does comparative history stack up against more dynamic approaches, such as connected, transnational, and postcolonial histories? Gérard Colas, for his part, claims that comparisons cannot allow one to move away from the dominant Euroamerican conceptual framework. Should this indeed be the case, we should search for better ways of facilitating a “mutual pollination” between philosophies. Finally, Edmond Eh first asserts that Sivin fails to recognize the difference between comparisons within cultures and comparisons between cultures. He then argues that the application of generalism is limited to comparisons of historical nature. (shrink)

the purpose of this paper is to o er a logico‐philosophical critical overview of the theory of multiple realities (tWr). the paper is divided into three sections. In the rst section I present a brief history of the development of some ideas, which combined together form the conceptual amework of the theory in question, whose main thesis is that there is more than one reality. In the second part I present (and try to address) some interpretations of tWr, which can (...) be described as: ontological; epistemological; esthetical; logical ad mixed interpretations. When do‐ ing so, a special emphasis is laid on the presentation of an explication of tWr based on theory of models, an explication authored by teresa Kostyrko. this explication rests on a conditional recognition of the particular ‘realities’ of Chwistek’s theory as proper models (i.e. those, which ful ll the condition of the identity of meaning of theory’s fundamental notions) of the theories of reality, with the provision that such models are indeed constructible. In the last section of my paper I propose a preliminary appraisal of the tWr as well as a way to reengineer this theory in order to avoid some of its di culties. By appealing to Kostyrko’s idea on one hand and the spirit Quinean ontological relativism on the other, I wish to argue as follows: ‘reality’ is the name of the set comprising all meanings of the term ‘reality’; under particular conditions these meanings can be arranged in a theory, which posseses a proper model (scienti c discourse, some forms of the common talk); model proper designate by de nition classes of objects, which we regard as existent on the grounds of a given theory. the above set of theses forms the core of a concept, which I propose to call the ‘manifold reality’ in order to di erentiate it om tWr, the development of which theory it is, as well as its modi cation towards a new kind of ontology. (shrink)

By extending Husserl’s own historico-critical study to include the conceptual mathematics of more contemporary times – specifically category theory and its emphatic development since the second half of the 20th century – this paper claims that the delineation between mathematics and philosophy must be completely revisited. It will be contended that Husserl’s phenomenological work was very much influenced by the discoveries and limitations of the formal mathematics being developed at Göttingen during his tenure there and that, subsequently, the rôle he (...) envisaged for his material a priori science is heavily dependent upon his conception of the definite manifold. Motivating these contentions is the idea of a mathematics which would go beyond the constraints of formal ontology and subsequently achieve coherence with the full sense of transcendental phenomenology. While this final point will be by no means proven within the confines of this paper it is hoped that the very fact of opening up for the possibility of such an idea will act as a supporting argument to the overriding thesis that the relationship between mathematics and phenomenology must be problematised. (shrink)

Manifold expressions of a particular critique appear throughout Søren Kierkegaard’s pseudonymous corpus: for Kierkegaard and his pseudonyms faith is categorically not a first immediacy, and it is certainly not the first immediate, the annulment of which concludes the first movement of Hegelian philosophy. Kierkegaard’s pseudonyms make it clear that he holds the Hegelian dogmaticians responsible for the promulgation of this misconception, but when Kierkegaard’s journals and papers are consulted another transgressor emerges: the renowned anti-idealist F.D.E. Schleiermacher. I address the (...) extent to which this particular indictment is justified; over-against Gerhard Schreiber, I argue that this characterization of Schleiermacher’s view of religion is indeed a de facto critique. I begin by presenting and demonstrating the ubiquity of the phenomenon at the heart of Schleiermacher’s conception of perfect God-consciousness, then proceed to apply criticisms raised by Kierkegaardian pseudonyms Judge William, Vigilius Haufniensis, Johannes Climacus, and Anti-Climacus, supplemented with concerns raised by Kierkegaard himself, in order to demonstrate that these criticisms do indeed apply to and problematize Schleiermacher’s view. (shrink)

Great man of culture, history and science Dmitry Cantemir, the prince of Moldavia was also a grate apologist of the Romanian religious traditions. In our study we try to underline this aspect from his writings, especially from his work Descriptio Moldavie. Therefore, we had followed the apologetics ideas from his most important works, like: Divanul, Loca Obscura, Descriptio Moldaviae, Metafizica and also from his Logica. In this context, the cultural and theological contribution of the great Moldavian scholar is very (...) important from the orthodox theology. In the actual context, Dmitry Cantemir shows the perfect example in the accomplishment and conservation of the Romanian authentic spirit over the centuries. (shrink)

This thesis is an interrogation of the viability of transitive production, which I associate with the Aristotelian term hylomorphic. The central axiom of hylomorphic production that will be targeted for critique is that the agent of production must be distinguished absolutely from the product. The thesis follows the thought of production primarily-but not exclusively-in its characteristically modem instantiation in the Kantian transcendental. The argument seeks to demonstrate that the productive aspect of the operator of transitive production is incompatible with the (...) transcendental element, and that Kant was himself increasingly aware of this problem. The Third Critique, under the rubric of an aesthetics, it will be argued, manifests this awareness in its problematic of a manifold of empirical laws. That this constitutes a difficulty for transcendent idealism means that the transcendental operators of the First Critique have failed to constitute experience in a relevant and important way. Furthermore, it is possible to see in some of the famous slogans of the Third Critique, an indication of another mode of production which is immune to the difficulties of the axiom of transitive production. In conclusion I suggest that the consequences of this new mode of intransitive production, associated with materiality, is destructive of the thought of the axiomatic otherworldliness of production operators. Production is not operated at all. Some suggestions are then made as to the explanation of the error embodied in the axiom of transitivity. (shrink)

En la teoría epistémica de Tomás de Aquino la lumen rationis desempeña la función de causa última del inventario completo del conocimiento humano natural. La tesis de acuerdo a la cual esa luz es puesta en nosotros por Dios justifica, de acuerdo al autor, la aserción de que la divinidad es el único y auténtico maestro interior del hombre. Ahora bien, en la visión beatífica la lumen naturale es perfeccionada por una luz sobrenatural, y la unión cognitiva con lo conocido (...) tiene lugar por la presencia real de Dios mismo en el entendimiento humano, única instancia en la que resulta conocido tal como es. Restringidos, en cambio, al modus intelligendi natural, la presencia cognitiva de la realidad divina solo puede ser representacional y, por lo tanto, según el autor, limitada, lo que repugna esencialmente a la divinidad. La esencia divina, en este caso, solo puede ser concebida de manera deficiente: por espejo y en enigma. En este trabajo intentamos explorar las diferencias entre ambos tipos de cogniciones tomando en cuenta los dos modos correlativos en que Dios nos enseñaría acerca de sí: ya de manera perfecta, como en la visión beatífica, ya de manera obscura, es decir, en enigma. (shrink)

Imaginative representations are crucial to the generation of action--both pretense and plain action. But well-known theories of imagination on offer in the literature [1] fail to describe how perceptually-formatted imaginings (mental images) and motor imaginings function in the generation of action and [2] fail to recognize the important fact that spatially rich imagining can be integrated into one's perceptual manifold. In this paper, I present a theory of imagining that shows how spatially rich imagining functions in the generation of (...) action. I also describe the imaginative structures behind two under-explored forms of action: semi-pretense and pretense layering. In addition, I suggest that my theory of imagining meshes better than the competitors with current work in cognitive and affective neuroscience. (shrink)

: Este trabalho busca elucidar a constituição do ego transcendental na Fenomenologia da Vida de Michel Henry (1922-2002). Inicialmente, apresentaremos brevemente a constituição de sentido a partir do ego transcendental conforme proposto por Edmund Husserl (1859-1938). Em seguida, discutiremos a problemática deste ego transcendental, visto que, para Henry a fenomenologia husserliana deixa obscura a região de ser do próprio ego. Henry argumenta que o ego transcendental não se constitui por si mesmo; ele é secundário em relação ao que o (...) constitui. O que precede e possibilita o próprio ego transcendental é a região de ser que Michel Henry denomina como Vida. Deste modo, o ego não se autoconstitui, mas ele surge passivamente desta região ontológica a partir do nascimento transcendental. Uma vez que esta Vida é o fundamento, ela é a condição ontológica que possibilita toda a manifestação. Para este estudo, serão utilizadas as obras L’Essence de la manifestation (2011), Phénoménologie de la vie: Tome I, De la phénoménologie (2003), e Phénoménologie de la vie: Tome III, de l’art et du politique (2003). Portanto, é necessário compreender como opera a radicalização na Fenomenologia da Vida de Michel Henry para alcançar o sentido do fundamento que constitui o ego transcendental, identificado como região ontológica da Vida. (shrink)

The clean separation between manifold phenomena and a systematic order that prevails in them is a basic feature of the rational-scientific orientation system. The first authoritative formulation of this premise is found in Plato. His discussion of constitutive forms of world events has initiated a broad development in the history of philosophy, which is also effective today in the preference for reason-guided analyses of often confusing circumstances. The authors of this volume address the lasting relevance of this idea within (...) two interrelated areas of research, namely Plato scholarship and contemporary Platonism. Of particular interest is the relationship between Plato and Wittgenstein. Following this overall idea, this volume is divided into three sections: Plato scholarship, Platonism, and Plato and Wittgenstein. As the contributions show, Platonism proves to be not only a purely historical-exegetical field of research but rather a fruitful stimulus for contemporary discussions on logical, linguistic, and social topics. (shrink)

Relativity theory is often said to support something called ‘the four-dimensional view of reality’. But there are at least three different views that sometimes go by this name. One is ‘spacetime unitism’, according to which there is a spacetime manifold, and if there are such things as points of space or instants of time, these are just spacetime regions of different sorts: thus space and time are not separate manifolds. A second is the B-theory of time, according to which (...) the past, present, and future are all equally real and there is nothing metaphysically special about the present. A third is perdurantism, according to which persisting material objects are made up of different temporal parts located at different times. We sketch routes from relativity to unitism and to the B-theory. We then discuss some routes to perdurantism, via the B-theory and via unitism. (shrink)

The paper considers the symmetries of a bit of information corresponding to one, two or three qubits of quantum information and identifiable as the three basic symmetries of the Standard model, U(1), SU(2), and SU(3) accordingly. They refer to “empty qubits” (or the free variable of quantum information), i.e. those in which no point is chosen (recorded). The choice of a certain point violates those symmetries. It can be represented furthermore as the choice of a privileged reference frame (e.g. that (...) of the Big Bang), which can be described exhaustively by means of 16 numbers (4 for position, 4 for velocity, and 8 for acceleration) independently of time, but in space-time continuum, and still one, 17th number is necessary for the mass of rest of the observer in it. The same 17 numbers describing exhaustively a privileged reference frame thus granted to be “zero”, respectively a certain violation of all the three symmetries of the Standard model or the “record” in a qubit in general, can be represented as 17 elementary wave functions (or classes of wave functions) after the bijection of natural and transfinite natural (ordinal) numbers in Hilbert arithmetic and further identified as those corresponding to the 17 elementary of particles of the Standard model. Two generalizations of the relevant concepts of general relativity are introduced: (1) “discrete reference frame” to the class of all arbitrarily accelerated reference frame constituting a smooth manifold; (2) a still more general principle of relativity to the general principle of relativity, and meaning the conservation of quantum information as to all discrete reference frames as to the smooth manifold of all reference frames of general relativity. Then, the bijective transition from an accelerated reference frame to the 17 elementary wave functions of the Standard model can be interpreted by the still more general principle of relativity as the equivalent redescription of a privileged reference frame: smooth into a discrete one. The conservation of quantum information related to the generalization of the concept of reference frame can be interpreted as restoring the concept of the ether, an absolutely immovable medium and reference frame in Newtonian mechanics, to which the relative motion can be interpreted as an absolute one, or logically: the relations, as properties. The new ether is to consist of qubits (or quantum information). One can track the conceptual pathway of the “ether” from Newtonian mechanics via special relativity, via general relativity, via quantum mechanics to the theory of quantum information (or “quantum mechanics and information”). The identification of entanglement and gravity can be considered also as a ‘byproduct” implied by the transition from the smooth “ether of special and general relativity’ to the “flat” ether of quantum mechanics and information. The qubit ether is out of the “temporal screen” in general and is depicted on it as both matter and energy, both dark and visible. (shrink)

Há muito tempo, o filme noir americano tem sido objeto de estudos críticos, que buscam decifrar a sua estética enigmática e a mensagem desafiadora. Trilhando sobre o lado mais negativo da vida humana, a questão central que ele propõe é: o que o noir representa, como forma singular de arte cinematográfica? Ora, compreender o filme noir passa pela necessidade de vê-lo no âmbito da matriz histórica de produção que lhe serviu de berço. Essa matriz é o chamado cinema clássico hollywoodiano, (...) à luz do qual iniciaremos a nossa investigação do significado desse ciclo de filmes, com base em um sumário desenvolvido pelo professor David Bordwell, autoridade em narrativa clássica. Para tanto, nós buscaremos subsídios conceituais em uma corrente de pensamento igualmente ampla, a fenomenologia hermenêutica, que, acreditamos, poderá nos proporcionar alguma elucidação semântica, tendo em vista o notório esforço dos filósofos dessa tradição para clarificar o propósito da obra de arte, no ser da existência. Assim, ao estabelecer como termos comparativos o cinema clássico e a inquirição hermenêutica, conseguiremos padrões de referência sólidos para a nossa atividade exegética, que tanto se aplica ao conjunto dos filmes noir - especialmente aos da fase clássica, dos anos 1940 e 50 - quanto a um longa-metragem individual. Nessa empreitada, porém, não partiremos do zero, como se o cinema houvesse começado ontem. Antes, nos servirá de fio condutor certa teoria explicativa da técnica cinematográfica, em cujos esteios figuram nomes como André Bazin, Ismail Xavier e Marcia Ortegosa, além de Bill Nichols, o principal expoente dos estudos sobre documentários. Tal explanação de teor linguístico e semiótico, com ênfase nos aspectos lógicos-metadiscursivos do filme noir, será discriminada logo no início do trabalho, para que possamos firmar parâmetros de julgamento crítico, tendo em vista a reflexão semântica e fenomenológica que se seguirá. O objetivo dessa reflexão é entender o assim chamado dark cinema no seio do nosso próprio modo de ser no mundo. Dessa forma, se conseguirmos trazer um pouco de luz às trilhas obscuras do mundo noir, este autor se dará por recompensado. (shrink)

REPRODUÇÃO ANIMAL: O CICLO ESTRAL DE BOVINOS LEITEIROS – Desenvolvimento Folicular, Corpo Lúteo e Etapas do Estro ANIMAL REPRODUCTION: THE OESTROUS CYCLE OF DAIRY BOVINES -Follicular Development, Corpus Luteum and Stages of Estrus Apoio: Emanuel Isaque Cordeiro da Silva Departamento de Zootecnia da UFRPE E-mail: [email protected] WhatsApp: (82)98143-8399 FISIOLOGIA CLÍNICA DO CICLO ESTRAL DE BOVINOS LEITEIROS 1. RESUMO A fêmea bovina apresenta ciclos estrais em intervalos de 19 a 23 dias e estes só são interrompidos durante a gestação ou devido (...) a alguma patologia. O estro é o período de aceitação da cópula e tem uma duração de 8 a 18 horas. Durante o metaestro ocorre a ovulação e se desenvolve o corpo lúteo. O diestro é o estágio mais longo do ciclo e é caracterizado pela presença de um corpo lúteo. Se a gestação não for estabelecida, o endométrio segrega prostaglandina F2α(PGF2α) o que induz a luteólise, reiniciando assim um novo ciclo. 2. EIXO HIPOTÁLAMO-HIPÓFISE-OVÁRIO As hormonas são substâncias produzidas por diferentes células do organismo que exercem funções específicas em outras células (células brancas). Algumas hormonas atuam na mesma célula que a secreta (atividade autocrina), outras nas células vizinhas (atividade parácrina) e outras são transportadas pelo sangue e exercem a sua função em células de outros órgãos (atividade endócrina). Existem outros tipos de hormônios que comunicam a diferentes indivíduos e são conhecidos como feromônios. Os feromônios regulam diferentes funções, entre as quais se destacam as reprodutivas. O hipotálamo encontra-se na base do cérebro, é formado por núcleos pares de neurônios e comunica-se com a hipófise através de um sistema circulatório especializado conhecido como sistema porta-hipotálamo-hipofisário. Os neurônios da área ventromedial e da área pré-óptica do hipotálamo secretam a hormona libertadora das gonadotropinas (GnRH), que por sua vez chega à hipófise através do sistema porta-hipotálamo-hipofisário e estimula a secreção da hormona luteinizante (LH) e da hormona folículo estimulante (FSH). A LH mantém um padrão de secreção paralelo à secreção da GnRH; ou seja, uma parcela de GnRH corresponde a uma parcela de LH, ao contrário da FSH que tem uma produção basal elevada inibida pelo estradiol e inibina, por este motivo, a sua secreção não apresenta um padrão pulsante semelhante à LH. A GnRH tem duas formas de secreção: a primeira é pulsante ou tônica, regulada por estímulos externos (fotoperíodo, bioestimulação, amamentação) e por estímulos internos (metabolitos, hormonas metabólicas, hormonas sexuais); a segunda forma é pré-ovulatória ou cíclica e é estimulada pelos estrogênios durante o estro e inibida pela progesterona. A secreção de alguns hormônios, bem como diversos processos fisiológicos, são sincronizados com a duração do dia e da noite (ritmos endógenos). A luz é percebida pelos fotorreceptores da retina e o sinal luminoso chega à glândula pineal através de conexões neuronais (trato retino-hipotalâmico). Na glândula pineal, o estímulo produzido pela luz inibe a síntese da melatonina. Desta forma, a duração do dia e da noite (fotoperíodo) é registada pelas variações nas concentrações da melatonina. Na vaca, sabe-se que o fotoperíodo influencia alguns processos reprodutivos, embora não seja, em sentido estrito, uma espécie com um padrão reprodutivo sazonal. Os feromônios sexuais são excretados através da urina, fezes e fluidos corporais; eles são percebidos pelo epitélio olfatório e órgão vomeronasal. Posteriormente, algumas vias nervosas, estimulam no hipotálamo a frequência dos pulsos de secreção da GnRH. A exposição a feromonas femininas provoca no macho um aumento na frequência de secreção do LH e isto por sua vez aumenta as concentrações de testosterona. Os feromônios masculinos induzem na fêmea um aumento da frequência de secreção do LH, estimulando o crescimento folicular e a secreção de estradiol. A estimulação sexual provocada pelo macho ou pela fêmea é denominada bioestimulação. As alterações na condição corporal estão positivamente correlacionadas com as concentrações séricas de insulina, fator de crescimento semelhante à insulina tipo I (IGF- I) e leptina. Assim, quanto maior a classificação da condição corporal, maior é a concentração sérica destas hormonas, que atuam como sinais que chegam ao hipotálamo e modificam a frequência de secreção da GnRH. Por exemplo, a transição do anestro para a ciclicidade coincide com um aumento da condição corporal e das concentrações de insulina, IGF- I e leptina (figura 1). Figura 1. A transição do anestro para a ciclicidade coincide com um aumento da condição corporal e das concentrações de insulina, IGF- I e leptina. Estas hormonas atuam como sinais que chegam ao hipotálamo e aumentam a frequência de secreção da GnRH. Fonte: GALINA, et al. 2008. Os estrogênios podem ter um feedback positivo ou negativo sobre a secreção da GnRH, o que depende da fase do ciclo reprodutivo. Em animais pré-púberes e em anestro pós-parto, os estrogênios inibem a secreção de GnRH, mas durante o período de proestro e estro há uma estimulação para a secreção de GnRH. A progesterona reduz a secreção da GnRH, bem como a resposta da hipófise à GnRH, inibindo assim a maturação folicular e a ovulação. Por esta razão, a progesterona foi utilizada com sucesso como contraceptivo em humanos e para o controle artificial da reprodução em animais domésticos (figura 2). Figura 2. Retroalimentação entre o hipotálamo, hipófise e o ovário. A GnRH estimula na hipófise a síntese e secreção de LH e FSH. Na fase pré-púbere e no anestro pós-parto, os estrogênios inibem a secreção de GnRH, enquanto no proestro e estro, estimulam-na. A progesterona inibe a secreção da GnRH e diminui a resposta da hipófise à GnRH. Os estrogênios e a inibina suprimem a secreção de FSH diretamente na hipófise. Fonte: GALINA, et al. 2008. Os neurônios secretores da GnRH não têm receptores para estrogênios nem progesterona, pelo que estas hormonas não têm forma de regular diretamente a secreção da GnRH. Existe um grupo de neurônios hipotalâmicos que exprimem o gene Kiss-1 que codifica o peptídeo kisspeptina. Os neurônios secretores da GnRH têm receptores para este peptídeo, de modo que a kisspeptina fornece a informação aos neurônios secretores da GnRH em relação às concentrações de hormônios sexuais. A kisspeptina é um potente estimulador (secretagogo) da secreção da GnRH e é muito provável que nos próximos anos venha a fazer parte dos recursos hormonais para o controle artificial da reprodução, não só nos bovinos, mas em todas as espécies domésticas. 3. DESENVOLVIMENTO FOLICULAR O ovário é responsável pela produção de ovócitos e pela síntese de hormônios sexuais, estrogênios e progesterona, que promovem e regulam a fertilização do ovócito e a manutenção da gestação. O ovócito encontra-se no interior do folículo ovárico rodeado por células granulosas que participam de forma ativa no seu crescimento e maturação. As experiências in vitro demonstram a dependência dos ovócitos das células da granulosa, assim, quando os ovócitos são induzidos a amadurecer devem estar rodeados por várias camadas de células da granulosa para que este processo seja bem sucedido, caso contrário, não adquirem o potencial para desenvolver um embrião. Embora as células da teca interna não estejam em contato direto com o ovócito, seu papel na maturação deste o exercem mediante a produção de andrógenos, mesmos que são convertidos em estrogênios pelas células da granulosa. Além disso, as células da teca favorecem o estabelecimento da rede capilar que apoia o desenvolvimento folicular. Por outro lado, os novos conhecimentos indicam que o ovócito não é um elemento passivo no desenvolvimento folicular, mas regula a função das células foliculares; o que significa que ele próprio participa na criação de um microambiente ideal para a sua maturação. Além disso, é possível que o ovócito tenha um papel na ativação do desenvolvimento dos folículos primordiais. A fêmea bovina nasce com aproximadamente 200 mil folículos, dos quais muito poucos se ativam e iniciam seu crescimento, e a maior parte deles sofre atresia em diferentes etapas de desenvolvimento. Ao nascimento, os folículos estão na fase mais elementar e são conhecidos como folículos primordiais. Posteriormente estes folículos se ativam e se transformam em folículos primários e secundários; até este momento os folículos não têm antro (etapa pré-antral) e seu desenvolvimento é independente das gonadotropinas. Quando os folículos formam o antro são conhecidos como folículos terciários e seu desenvolvimento é dependente das gonadotropinas (etapa antral). O crescimento folicular no estágio antral ocorre em forma de ondas e cada onda começa com um aumento nos níveis de FSH, o qual promove o crescimento de um grupo de cinco a seis folículos (~4 mm de diâmetro); este processo é conhecido como recrutamento. Subsequentemente, um único folículo continua a crescer (folículo dominante), o que provoca um aumento das concentrações de estrogênios e inibina, uma diminuição das concentrações de FSH e atresia dos folículos subordinados, pois eles dependem totalmente desta hormona, enquanto o folículo dominante continua o seu desenvolvimento estimulado pela LH. O folículo dominante perdura de quatro a seis dias e se não chega a ovular, sofre atresia. Após a atresia do folículo dominante, diminuem-se os níveis de estrogênio e inibina, observa-se um aumento das concentrações de FSH e inicia-se uma nova onda folicular. O folículo dominante que está presente quando o corpo lúteo sofre regressão, continua seu desenvolvimento e ovula, em resposta ao pico pré-ovulatório de LH. Além de promover a liberação do ovócito, a secreção pré-ovulatória de LH regula a formação do corpo lúteo a partir das células foliculares, processo conhecido como luteinização. Durante o ciclo estral são apresentadas de duas a três ondas foliculares. As vacas com três ondas foliculares têm uma fase lútea mais longa e, consequentemente, um ciclo estral mais longo, de 22 a 23 dias; enquanto as vacas com duas ondas apresentam um ciclo estral de 18 a 21 dias. Nas vacas leiteiras, cerca de 70% apresentam duas ondas foliculares, enquanto 30% exibem três ondas (figura 3 e 4). Nas vacas com duas ondas foliculares, o período de dominação folicular é maior do que nas de três ondas. O tempo de dominação influencia o potencial dos ovócitos para desenvolver um embrião viável; assim, a porcentagem de concepção é menor quando ovulam folículos que tiveram mais dias de dominação dos que quando ovulam folículos com menor tempo de dominação (figura 5). Figura 5. O crescimento folicular no estágio antral ocorre na forma de ondas. Cada onda começa com um aumento nas concentrações de FSH, o que promove o recrutamento de cinco a seis folículos (~4 mm de diâmetro). Posteriormente um único folículo continua crescendo (folículo dominante), enquanto seus companheiros (subordinados) sofrem atresia. O folículo dominante perdura de quatro a seis dias e se não chega a ovular, sofre atresia. Após a atresia do folículo dominante observa-se um aumento das concentrações de FSH, iniciando-se uma nova onda folicular. 3.1 Ovulação múltipla Nos últimos anos tem-se observado um aumento na proporção de vacas com ovulação múltipla (20% x 1% em novilhas), o que tem provocado um aumento da proporção de partos gêmeos (8% x 1% em novilhas). A frequência de vacas com ovulação múltipla está associada com a alta produção de leite; de modo que, as vacas que produzem menos de 40 kg mostram 6% de ovulações múltiplas e aquelas que produzem mais de 50 kg alcançam até 50%. A causa deste fenômeno ainda é obscura, contudo, observaram-se diferenças nas concentrações de FSH, de tal forma que as vacas que desenvolvem de dois a três folículos dominantes numa onda folicular, apresentam níveis de FSH mais elevados que as vacas que têm apenas um folículo dominante. Em vacas em lactação, a concentração de progesterona é baixa devido ao aumento do metabolismo hepático, o que aumenta a sua taxa de eliminação. Foi observado que as vacas que tiveram uma fase lútea com níveis de progesterona mais elevados, no ciclo anterior à inseminação, apresentam menos ovulações múltiplas em comparação com as vacas que tiveram níveis de progesterona mais baixos. Propõe-se que as baixas concentrações de progesterona permitam um aumento da frequência de secreção da GnRH e, consequentemente, da LH e da FSH, favorecendo a predominância múltipla e, eventualmente, a ovulação de mais de um folículo. Nos rebanhos leiteiros, as gestações gêmeas não são desejáveis porque aumenta o risco de perda da gestação e, se esta chegar ao término, haverá o risco de perda da gestação e, se esta for concluída, o risco de distorcia é consideravelmente mais elevado (figuras 6, 7, 8 e 9). Figura 6. As baixas concentrações de progesterona sérica nas vacas em lactação permitem um aumento da frequência de secreção da GnRH, bem como o aumento da LH e da FSH. Isto favorece a dominação múltipla e eventualmente a ovulação de mais de um folículo. Esta figura mostra a dominância de dois folículos em cada onda folicular (codominância). Figura 7. Ovários de uma vaca leiteira em diestro com três folículos dominantes. Figura 8. Ovários de uma vaca leiteira com três corpos lúteos. Figura 9. Ovários de uma vaca leiteira com dois corpos hemorrágicos. Fonte: Acervo pessoal do autor. IFPE, 2017-18. 4. DESENVOLVIMENTO E CONTROLE DA FUNÇÃO DO CORPO LÚTEO Quando o folículo dominante completa sua maturação, ele produz níveis de estrogênio suficientes para provocar a liberação máxima da GnRH, o que desencadeia o pico pré-ovulatório da LH. Esta secreção de LH provoca a ovulação e inicia as mudanças para que o folículo se transforme em um corpo lúteo, processo conhecido como luteinização. A luteinização compreende todas as mudanças morfológicas, endócrinas e enzimáticas que ocorrem no folículo ovulatório até que este se transforme num corpo lúteo. O processo de luteinização começa a partir da elevação pré-ovulatória de LH; mesmo antes da ovulação. A luteinização do folículo dominante (≥8 mm de diâmetro) pode ser induzida hormonalmente pela injeção de GnRH ou gonadotropina coriónica humana (hCG). A ovulação ocorre em média 30 horas após o pico pré-ovulatório de LH. A secreção pré-ovulatória de LH desencadeia a liberação de enzimas proteolíticas e de mediadores da inflamação na parede folicular, as quais degradam o tecido conjuntivo e ocasionam morte celular. Posteriormente, a PGF2α induz contrações da teca externa, levando à ruptura folicular e à expulsão do ovócito. Após a ovulação, as células da teca interna e da granulosa migram e distribuem-se nas paredes do folículo. As células da teca interna se diferenciam e se multiplicam em células lúteas pequenas, enquanto que as células da granulosa se hipertrofiam e dão origem às células lúteas grandes. Estas alterações são facilitadas pela ruptura da membrana basal que separa a camada celular da granulosa da teca interna. Em forma paralela começa a formação de uma ampla rede de capilares que se distribuem em todo o corpo lúteo em formação, e chegam a constituir até 20% do volume desta estrutura (figuras 10 e 11). A progesterona é o principal produto de secreção do corpo lúteo. No quinto dia do ciclo estral, as concentrações séricas desta hormona são superiores a 1 ng/ ml, indicando que o corpo lúteo adquiriu a sua plena funcionalidade. A progesterona atua basicamente sobre os órgãos genitais da fêmea, sendo responsável pela preparação do útero para o estabelecimento e manutenção da gestação. Na mucosa do oviduto e do útero, estimula a secreção de substâncias que promovem o desenvolvimento do embrião, até que este comece a nutrir-se através da placenta. A progesterona suprime a resposta imunitária do útero, o que é necessário para tolerar o embrião, já que este é um tecido estranho para a vaca. Além disso, a progesterona evita as contrações do útero, fecha o colo do útero e modifica as características do muco cervical, tornando-o mais viscoso, impedindo a passagem de agentes estranhos para o interior do útero. Na glândula mamária estimula o desenvolvimento do sistema alveolar, preparando-a para a síntese e a secreção de leite. 5. REGRESSÃO DO CORPO LÚTEO A regressão lútea é um processo ativo ocasionado pela secreção uterina da PGF2α. O mecanismo pelo qual se inicia a síntese e secreção da PGF2α depende de uma interação entre o corpo lúteo, os folículos e o útero. Os estrogênios produzidos no folículo dominante desempenham um papel importante no início da secreção de PGF2α, uma vez que promovem a síntese de receptores para oxitocina. Além disso, os estrogénios estimulam no endométrio a produção da fosfolipase A e da ciclooxigenase; enzimas indispensáveis para a síntese da PGF2α. Durante o ciclo estral, a progesterona inibe a síntese da PGF2α através da supressão da formação de receptores para o estradiol. Após um período de 12 a 14 dias de exposição à progesterona, as células endometriais tornam-se insensíveis à progesterona. Quando isso ocorre, as células endometriais sintetizam receptores para estradiol, permitindo que o estradiol produzido no folículo dominante estimule a síntese de receptores para oxitocina. Neste momento, o endométrio está pronto para sintetizar e secretar PGF2α, em resposta ao estímulo da oxitocina. A primeira secreção de oxitocina é de origem hipotalâmica, o que desencadeia o primeiro pulso de PGF2α. Os seguintes episódios de PGF2α são induzidos pela oxitocina produzida no corpo lúteo. A PGF2α é secretada em episódios (pulsos) com intervalos de seis a oito horas, sendo necessários cinco a seis episódios para a luteólise ocorrer. Se a PGF2α não seguir este padrão de secreção, a regressão do corpo lúteo falhará. Além da PGF2α de origem uterina, o corpo lúteo também produz PGF2α, que aumenta o efeito luteolítico. A falta de sensibilidade à PGF2α observada nos corpos lúteos imaturos (primeiros cinco dias após a ovulação) deve-se ao fato de, neste período, o corpo lúteo ainda não produzir PGF2α (figura 12, 13 e 14). 6. ETAPAS DO CICLO ESTRAL O ciclo estral é dividido em quatro etapas bem definidas. 6.1 Estro Neste estágio a fêmea aceita a cópula ou a monta de outra vaca. O estro é provocado pelo aumento significativo das concentrações de estradiol produzido pelo folículo pré-ovulatório e pela ausência de um corpo lúteo. A duração desta etapa é de 8 a 18 horas. 6.2 Metaestro O metaestro é a etapa posterior ao estro, tem uma duração de quatro a cinco dias. Durante esta etapa ocorre a ovulação e se desenvolve o corpo de lúteo. Após a ovulação, observa-se uma depressão no lugar ocupado pelo folículo ovulatório (depressão ovulatória) e, posteriormente, se desenvolve o corpo hemorrágico (corpo lúteo em processo de formação). Durante o metaestro, as concentrações de progesterona começam a aumentar até atingirem níveis superiores a 1 ng/ml, momento a partir da qual considera-se que o corpo lúteo atingiu a maturidade. O momento em que as concentrações de progesterona são superiores a 1 ng/ml toma-se como critério fisiológico a determinação do fim do metaestro e o início do diestro. Um evento hormonal que se destaca neste período consiste na apresentação do pico pós-ovulatório de FSH, o qual desencadeia a primeira onda de desenvolvimento folicular. Algumas vacas apresentam sangramento conhecido como sangramento metaestral (figura 15). 6.3 Diestro O diestro é o estágio de maior duração do ciclo estral, de 12 a 14 dias. Durante este estágio o corpo lúteo mantém sua plena funcionalidade, o que se reflete em concentrações sanguíneas de progesterona, maiores que 1 ng/ml. Além disso, nesta fase, pode-se encontrar folículos de tamanho diferente devido às ondas foliculares. Após 12-14 dias de exposição à progesterona, o endométrio começa a secretar PGF2α em um padrão pulsátil, ao qual termina com a vida do corpo lúteo e com o diestro. Em termos endócrinos, quando o corpo lúteo perde a sua funcionalidade, ou seja, quando as concentrações de progesterona diminuem abaixo de 1 ng/ml, finaliza-se o diestro e começa o proestro. Convém mencionar que durante esta fase, a LH é secretada com uma frequência muito baixa e a FSH tem incrementos responsáveis pelas ondas foliculares. 6.4 Proestro O proestro caracteriza-se pela ausência de um corpo lúteo funcional e pelo desenvolvimento e maturação do folículo ovulatório. O proestro na vaca dura de dois a três dias. Um evento hormonal característico desta etapa é o aumento da frequência dos pulsos de secreção de LH que levam à maturação final do folículo ovulatório e ao aumento do estradiol sérico, que desencadeia o estro. Para além da classificação do ciclo estral acima descrita, existe outra que divide o ciclo em duas fases: progestacional (lútea) e estrogênica (folicular). A fase progestacional inclui o metaestro e o diestro, e a fase estrogênica ao proestro e estro (figura 16). Figura 16. Etapas do ciclo estral. Adaptado e elaborado a partir de FERREIRA, 2010. 7. CONCLUSÕES PRÉVIAS  O ciclo estral dura de 19 a 23 dias.  A vaca é receptiva durante 8 a 18 horas (estro).  Ao nascimento uma bezerra tem cerca de 200 mil folículos primordiais.  Durante o ciclo estral se apresentam de duas a três ondas foliculares.  De cinco a seis folículos são recrutados em cada onda folicular.  Cerca de 70% das vacas têm duas ondas foliculares e 30% apresentam três ondas.  Entre 10 e 20% das vacas têm ovulações múltiplas (dois a três folículos) e 8% têm partos gêmeos.  A ovulação ocorre 30 horas após o pico pré-ovulatório de LH.  A secreção pré-ovulatória de LH é de 15 a 30 ng/ml.  12 a 14 dias são necessários para que o endométrio se torne insensível à progesterona e comece a secretar PGF2α. - São necessários cinco a seis pulsos de PGF2α com um intervalo de oito horas para ocasionar a luteólise.  O corpo lúteo não é sensível à PGF2α nos primeiros cinco dias do ciclo estral. Emanuel Isaque Cordeiro da Silva – Departamento de Zootecnia da UFRPE Recife, 2020. REFERÊNCIAS BIBLIOGRÁFICAS ALVES, Nadja Gomes; PEREIRA, Marcos Neves; COELHO, Rodrigo Michelini. Nutrição e reprodução em vacas leiteiras. Revista Brasileira de Reprodução Animal, p. l1248-l1248, 2009. ARBOLEDA, José Leonardo Ruiz; URIBE-VELÁSQUEZ, Luis Fernando; OSORIO, José Henry. Factor de crecimiento semejante a insulina tipo 1 (IGF-1) en la reproducción de la hembra bovina. Vet. zootec, v. 5, n. 2, p. 68-81, 2011. BARUSELLI, Pietro Sampaio; GIMENES, Lindsay Unno; SALES, José Nélio de Sousa. Fisiologia reprodutiva de fêmeas taurinas e zebuínas. Revista Brasileira de Reprodução Animal, v. 31, n. 2, p. 205-211, 2007. COLE, H. H.; CUPPS, P. T. Reproduction in domestic animals. 1ª ed. Londres: Academic Press, 1977. DA SILVA, Emanuel Isaque Cordeiro. Características Gerais dos Bovinos/General Characteristics of Cattle Bovine. Disponível em: ———. Acesso em: Fevereiro de 2020. DA SILVA, Emanuel Isaque Cordeiro. Definição de Conceitos Básicos na Reprodução Animal: Fertilidade, Fecundidade e Prolificidade-Suínos. Philarchive. Disponível em: ———. Acesso em: Fevereiro de 2020. DA SILVA, Emanuel Isaque Cordeiro. REPRODUÇÃO ANIMAL: OVULAÇÃO, CONTROLE E SINCRONIZAÇÃO DO CIO. Disponível em: ———. Acesso em: Fevereiro de 2020. DO VALLE, Ezequlel Rodrigues. O ciclo estral de bovinos e métodos de controle. Campo Grande: EMBRAPA-CNPGC, 1991. FERREIRA, A. M. Reprodução da fêmea bovina: fisiologia aplicada e problemas mais comuns. Juiz de Fora: Editar, 2010. GALINA HIDALGO, Carlos et al. Reproducción de animales domésticos. México: Limusa, 1988. HAFEZ, E. S. E.; HAFEZ, B. Reprodução animal. São Paulo: Manole, 2004. McDONALD, L.E. Veterinary endocrinology and reproduction. 3.ed. Philadelphia: Lea & Febiger, 1980. MELLO, R. R. C. et al. Desenvolvimento folicular inicial em bovinos. Revista Brasileira de Reprodução Animal, v. 37, n. 4, p. 328-333, 2013. MELLO, Raquel Rodrigues Costa et al. Aspectos da dinâmica folicular em bovinos. Agropecuária Científica no Semiárido, v. 10, n. 4, p. 01-06, 2015. NEBEL, Ray; DEJARNETTE, M. Anatomía y fisiología de la reproducción bovina. SELECT SIRES INC, v. 6, 2011. PALMA, Gustavo A. Biotecnología de la reproducción. Balcarce: Instituto Nacional de Tecnología Agropecuaria, 2008. PEREIRA, Elias de Oliveira. Fisiologia da reprodução em vacas leiteiras: REVISÃO DE LITERATURA. TCC Medicina Veterinária. Ituverava: FAFRAM, 2019. PETERS, A. R.; BALL, P. J. H. Reprodução em bovinos. São Paulo: Editora Roca, 2006. PRIETO-GÓMEZ, Bertha; VELÁZQUEZ-PANIAGUA, Mireya. Fisiología de la reproducción: hormona liberadora de gonadotrofinas. Rev Fac Med UNAM, v. 45, n. 6, p. 252-57, 2002. SALISBURY, Glenn Wade; LODGE, J. R.; VANDEMARK, N. L. Fisiología de la reproducción e inseminación artificial de los bóvidos. Zaragoza: Acribia, 1978. VIVEIROS, Ana Tereza de Mendonça. Fisiologia da reprodução de bovinos. Lavras: UFLA, 1997. (shrink)

Humean accounts of laws are often contrasted with governing accounts, and recent developments have added pragmatic versions of Humeanism. This paper offers Mitchell's pragmatist, perspectival account of laws as a third option. The differences between these accounts come down to the role of modality. Mitchell's bottom-up account allows for subtle gradations of modal content to be conveyed by laws. The perspectival character of laws is not an accident or something to be eventually eliminated - it is part of how this (...) modal content is conveyed. I conclude with a discussion of the metaphysical commitments in Humeanism as requiring a perspectiveless view of the manifold from outside, and how Mitchell's situated account is better able to account for the substantive notion of possibility involved in scientific laws. (shrink)

This article wants to analyze how Candido Portinari in his paintings with rural theme, engages a poetry of silence. To understand the functioning of this poetic language, we will adopt the Groupe μ analysis method (both the General Rhetoric andthe Treatise on theVisual Sign). Whereas the language is manifold as the forms of representation, and it present in all media, whatever the lack of speech -silence -would find its richest form in both directions through the metaphors and metonymy engaged (...) in metasememes of the paintings studied. (shrink)

In the Critique of Pure Reason and elsewhere, Kant uses the term ‘object’ in various ways and often without clearly signaling its different meanings. As a result, it is hard to gauge the extent to which Kant’s account of the object of cognition breaks new ground. In this article, I take the Critique to establish what is required to generate an object of cognition per se soleley by examining the various ways in which the human mind can objectify the content (...) of its representations. To clarify this endeavor, I distinguish four different ways in which the term ‘object’ is used in the Critique, namely, to refer to (1) material things, (2) the content of any type of thought, (3) the mind-immanent correlate of a cognition in the broad sense of the term, and (4) the mind-immanent correlate of a cognition in the strict sense of the term. On my reading, the fourth meaning of the term ‘object’ is key to the Transcendental Deduction and completes Kant’s unprecedented conception of the cognitive acts by means of which the human mind produces objects of cognition out of a manifold of representations. (shrink)

There is a popular theory in the metaphysics of time according to which time is one of four similar dimensions that make up a single manifold that is appropriately called spacetime. One consequence of this thesis is that changing an object’s orientation in the manifold does not change its intrinsic features. In this paper I offer a new argument against this popular theory. I claim that an especially good performance of a particularly beautiful piece of music, when oriented (...) within the manifold in the normal way, adds to the intrinsic value of the world, but that if the same performance is turned sideways within the manifold, so that it involves a number of different notes spread out in space and all occurring at the same time, then it does not add the same intrinsic value to the world. (shrink)

The human attempts to access, measure and organize physical phenomena have led to a manifold construction of mathematical and physical spaces. We will survey the evolution of geometries from Euclid to the Algebraic Geometry of the 20th century. The role of Persian/Arabic Algebra in this transition and its Western symbolic development is emphasized. In this relation, we will also discuss changes in the ontological attitudes toward mathematics and its applications. Historically, the encounter of geometric and algebraic perspectives enriched the (...) mathematical practices and their foundations. Yet, the collapse of Euclidean certitudes, of over 2300 years, and the crisis in the mathematical analysis of the 19th century, led to the exclusion of “geometric judgments” from the foundations of Mathematics. After the success and the limits of the logico-formal analysis, it is necessary to broaden our foundational tools and re-examine the interactions with natural sciences. In particular, the way the geometric and algebraic approaches organize knowledge is analyzed as a cross-disciplinary and cross-cultural issue and will be examined in Mathematical Physics and Biology. We finally discuss how the current notions of mathematical (phase) “space” should be revisited for the purposes of life sciences. (shrink)

In a recent article, Ned Markosian gives an argument against four-dimensionalism understood as the view that time is one of four identical dimensions that constitute a single four-dimensional manifold. In this paper, I show that Markosian attacks a straw man as his argument targets a theory known to be false on empirical grounds. Four-dimensionalism rightly conceived in no way entails that time is identical to space. I then address two objections raised by Markosian against four-dimensionalism rightly conceived.

When attempting to capture the concept of enlightenment that underlies and motivates philosophical (and political and scientific) developments in the 18th century, historians of philosophy frequently rely upon a needlessly but intentionally exclusive account. This, namely, is the conception of enlightenment first proposed by Kant in his famous essay of 1784, which takes enlightenment to consist in the “emergence from the self-imposed state of minority” and which is only possible for a “public” to attain as a result of the public (...) use of reason, a privilege enjoyed by citizens and exemplified in the activity of the scholar. That women, among other groups, did not hold the status of citizens and did not enjoy access to the institutions or training that might gain them recognition as scholars is apparently not a concern for Kant, as he notes that the enlightened condition is likely out of reach anyway for “by far the greatest part of humankind (including the entire fair sex)” (AA 8:35). This naturally leads one to wonder what a history of this period could look like when considered from the perspective of a different, more inclusive conception of enlightenment, and in this chapter I propose to conduct an experiment of sorts just along these lines. As opposed to Kant’s exclusionary conception, I will instead take that proposed by his distinguished contemporary, Moses Mendelssohn, as my starting point. In addition to offering a conception of enlightenment distinctive both for its wide scope and progressive character, Mendelssohn’s has the advantage, or so I will show, of bringing the manifold intellectual contributions of a diverse set of women into focus, though it does more than this in that it also reveals these women to actively and critically engage with key aspects of Mendelssohn’s and others’ philosophical views. (shrink)

The full Bayesian signi/cance test (FBST) for precise hypotheses is presented, with some illustrative applications. In the FBST we compute the evidence against the precise hypothesis. We discuss some of the theoretical properties of the FBST, and provide an invariant formulation for coordinate transformations, provided a reference density has been established. This evidence is the probability of the highest relative surprise set, “tangential” to the sub-manifold (of the parameter space) that defines the null hypothesis.

When a loved one dies, it is common for the bereaved to feel profoundly lonely, disconnected from the world with the sense that they no longer belong. In philosophy, this experience of ‘loss and loneliness’ has been interpreted according to both a loss of possibilities and a loss of the past. But it is unclear how these interpretations apply to the distinctive way in which loss and loneliness manifest in old age. Drawing on the phenomenological analyses of old age given (...) by de Beauvoir and Améry, I consider how the diminishment of the capacity for projection and recollection complicate recent interpretations of loss and loneliness, whilst nevertheless reinforcing the conclusion that in old age subjectivity is necessarily impoverished. Developing a critical stance on de Beauvoir and Améry’s underlying conception of subjectivity, I turn to Levinas in considering whether or not there is a way to reimagine subjectivity such that the estrangement and alienation of older adults might be ameliorated rather than exacerbated. Grounded in the passive body-in-itself rather than the self-transcending capacity of the body-for-itself, I suggest it becomes possible to reconceptualise the experience of loss and loneliness in old age; both in terms of what is lost and what needs to be restored if older adults are to be helped to find themselves at home in the world in the midst of, and indeed because of, manifold loss. (shrink)

In his recent JME article Daniel Restrepo argues that both legal and ethical rules should protect the so-called Naked Soldiers, combatants engaged in activity unrelated to military operations and unaware of the imminent danger threatening them. I criticize this position from several angles. I deny the existence of any link between vulnerability and innocence, and claim ignorance of deadly threats does not give rise to a morally distinguished type of vulnerability. I argue that actions not contributing to the war effort (...) are nevertheless an inherent part of fighting a war, and that combatants do not signal intention to abandon their commitment to the war effort by undertaking these. I show that by granting hors de combat status to Naked Soldiers, we would unjustly disadvantage their opponents and engender significant and manifold practical difficulties that the proponents of the view fail to solve or even anticipate. Finally, I demonstrate that Restrepo’s general project of “making killing in war difficult to legitimately justify” regardless of why, how and by whom the killing is done is incompatible with just war theory’s basic assumptions. That project is in fact pacifist in nature and as such redundant in light of pacifism’s broader and stronger implications. (shrink)

The purpose of this paper is to explore the connection between change and the B-theory of time, sometimes also called the Scientific view of time, according to which reality is a four-dimensional spacetime manifold, where past, present and future things equally exist, and the present time and non-present times are metaphysically the same. I argue in favour of a novel response to the much-vexed question of whether there is change on the B-theory or not. In fact, B-theorists are often (...) said to hold a ‘static’ view of time. But this far from being innocent label: if the B-theory of time presents a model of temporal reality that is static, then there is no change on the B-theory. From this, one can reasonably think as follows: of course, there is change, so the B-theory must be false. What I plan to do in this paper is to argue that in some sense there is change on the B-theory, but in some other sense, there is no change on the B-theory. To do so, I present three instances of change: Existential Change, namely the view that things change with respect to their existence over time; Qualitative Change, the view that things change with respect to how they are over time; Propositional Change, namely the view that things (i.e. propositions) change with respect to truth value over time. I argue that while there is a reading of these three instances of change that is true on the B-theory, and so there is change on the B-theory in this sense, there is a B-theoretical reading of each of them that is not true on the B-theory, and therefore there is no change on the B-theory in this other sense. (shrink)

The paper aims to give an account of practical knowledge by outlining a hylomorphic and conceptualist account of intentional action in analogy to McDowell's conceptualist account of experience. On this view, practical concepts provide the ideal or formal structure that unifies a manifold of bodily movements into a single intentional action, and hence intentional actions are structured conceptually. -/- - §1 sets out the basic features of this view in contrast to a common dualistic or two-component view of practical (...) knowledge, as an "inner" mental state with propositional content that functions as the efficient cause of some bodily movement in the "external" world, and introduces the claim that practical knowledge is the constitutive form of intentional action. - §2 illustrates the hylomorphic unity of concept and movement in action, and thus (contra Dreyfus) the corporeality of practical reason, by means of an account of practical concept formation, on which both the formation and tradition of practical concepts take place in bodily movement iself. - §3 elucidates the concept of a self-conscious disposition or rational capacity for action, actualizations of which are characterized by a syllogistic structure that accounts for both the explanation and the justification of action and thereby renders intelligible in what sense practical judgment is internal to acting itself. - Skillful exercises of such capacities express a knowledge-how that manifests itself in practical representations. §4 characterizes representations of this kind as a perceptually situated recognition of a practical pattern that amounts to the imaginative anticipation of a movement form by which the agent determines their next steps; a practical perception of the agent's particular situation that is both normative and motivational for them. - §5 starts by developing an identity theory of practical truth, on which the conceptual content of a (true) practical judgment is numerically identical with the formal structure of a (good) action, and concludes with explaining the unity of four features commonly attributed to practical knowledge, viz. that it is at the same time descriptive, normative, causally productive, and non-observational (or self-conscious). (shrink)

Kant’s derivation of the table of categories from logical functions of judgments in the metaphysical deduction remains one of the least convincing arguments of the Critique of Pure Reason. This article presents an alternative approach to the question of the a priori origin of the table of categories. By circumventing the metaphysical deduction, I show the possibility of demonstrating the exact functions and necessity of the twelve categorial forms as emerging from the interaction of the synthetic unity of apperception with (...) the manifold content of the a priori intuition of space and time. I argue that this a priori material of cognition imposes a constraint on the spontaneity of understanding, thus giving rise to the specific rules of synthesis that make up the table of categories. On the reading I suggest, the table of categories can be understood as expressing the a priori form of self-consciousness in the face of space and time. (shrink)

I offer an examination of a core element in the reflectiveness of Heraclitus’ thought, namely, his rebuke of polymathy . In doing so, I provide a response to a recent claim that Heraclitus should not be considered to be a philosopher, by attending to his paradigmatically philosophical traits. Regarding Heraclitus’ attitude to that naïve form of ‘wisdom’, i.e., polymathy, I argue that he does not advise avoiding experience of many things, rather, he advises rejecting experience of things as merely many (...) independent things in their manifoldness , and, instead, to understand their unity and thereby to unify our knowledge of them. (shrink)

In this article, I re-examine Kant’s many senses of cognition, thought, and object in order to better understand his account of logic, and, in particular, transcendental logic. In laying out the multiple and conflicting ways Kant defines each of those terms, the relation between transcendental logic and pure general logic can be revealed as analogous to, and, indeed, linked to, the isomorphism that exists between the categories of the understanding and the logical forms of judgment, which are equivalent if one (...) ignores the manifold of intuition. This means transcendental logic is a general logic, even as a logic of (some) cognizing. (shrink)

Almost any mainstream reading about the nature of Kant's 'content of cognition' in both non-conceptualist and conceptualist camps agree that 'singular representations' (sensible intuitions) are, at least in some weak sense, objectdependent because they supervene on a manifold of sensations that are given through the disposition of our sensibility and parallel thus the real and physical components of the world (cf. McDowell 1996, Allison 1983, Ginsborg 2008, Allais 2009). The relevant class of sensible intuitions should refer, as they argue, (...) only to empirical and not to pure ones. Kant's transcendental argument creates, however, no implications as to the metaphysics of properties. Neither does he consider the world to be consisted of sensory content simpliciter nor do sensations refer to objects per se. Instead, he provides an all-encompassing pattern for sensible intuitions of any kind through the representation of space as a cognitive map in that an object can be represented if spatial properties are attributed to it. Sensible intuitions of any kind could be referring, that is to say, and can be conceptualized if they are spatial. Consequently and unlike the contemporary philosophy of perception, Kant contrasts sensible intuitions and pure concepts of understanding 'altogether' against one single experience, from which the justification of objects should proceed. In other words, what stands at the core of exposing the content of cognition concerns not the phenomenological status and actuality of sensible intuitions in the sense of 'bits of experiential intake', but the logical structure of possibility of sensible intuitions of any (external or internal) causal background. The aim of this discussion is to clarify that Kant's transcendental idealism mutatis mutandis reviews multiple and diverse kinds of 'data of mind' and cognition in the background, without reducing the content of cognition to metaphysically determined referents as 'matters of fact' and to pure concepts of understanding. Sensible intuitions in the sense of content of cognition vary, most importantly, from unstructured and unjustifiable data of mind including (physical) contents of perception and stuff of mind and also from reflective and intellectual intuitions that are the cognates of the structured complex singular representations. Put it in simple terms, Kant advocates the thesis that 'facts' are objects for concepts if they are already well-founded trough the cognitive map of the representation of space. -/- . (shrink)

I advance a novel interpretation of Kant's argument that our original representation of space must be intuitive, according to which the intuitive status of spatial representation is secured by its infinitary structure. I defend a conception of intuitive representation as what must be given to the mind in order to be thought at all. Discursive representation, as modelled on the specific division of a highest genus into species, cannot account for infinite complexity. Because we represent space as infinitely complex, the (...) spatial manifold cannot be generated discursively and must therefore be given to the mind, i.e. represented in intuition. (shrink)

I criticize Lockwood’s solution to the “paradoxes” of time travel, thus endorsing Lewis’s more conservative position. Lockwood argues that only in the context of a 5D space-time-actuality manifold is the possibility of time travel compatible with the Autonomy Principle (according to which global constraints cannot override what is physically possible locally). I argue that shifting from 4D space-time to 5D space-time-actuality does not change the situation with respect to the Autonomy Principle, since the shift does not allow us to (...) have a coincidence-free local dynamical theory. (shrink)

Born 80 years ago, Continental Philosophy is on its last legs. Its extraordinary career has been helped along by an almost total absence of interest on the part of analytic or other exact philosophers in what the Australian philosopher David Stove calls "the nosology of philosophy" 1, the exploration of the manifold forms taken by bad philosophy. Stove points out that such an enterprise involves doing history. A nosology of Continental Philosophy is, at least in the first instance, inseparable (...) from the history of this strand in twentieth century philosophy, a history which would make clear the relations, philosophical and historical, between it and exact philosophy. Rorty is quite right to point to the absence of such a historical perspective. (shrink)

: In the first edition of his book on the completeness of Kant’s table of judgments, Klaus Reich shortly indicates that the B-version of the metaphysical exposition of space in the Critique of pure reason is structured following the inverse order of the table of categories. In this paper, I develop Reich’s claim and provide further evidence for it. My argumentation is as follows: Through analysis of our actually given representation of space as some kind of object, the metaphysical exposition (...) will show that this representation is secondary to space considered as an original, undetermined and as such unrepresentable intuitive manifold. Now, following Kant, the representation of any kind of object involves diversity, synthesis and unity. In the case of our representation of space as formal intuition, this involves, firstly, a manifold a priori, i.e. space as pure form, delivered by the transcendental Aesthetic, secondly, a figurative, productive synthesis of that manifold, and, thirdly, the unity provided by the categories. Analysing our given representation of space – the task of the metaphysical exposition – amounts to dismantling its unity and determine its characteristics with respect to the categories. (shrink)

This paper proposes an abstract mathematical frame for describing some features of biological time. The key point is that usual physical (linear) representation of time is insufficient, in our view, for the understanding key phenomena of life, such as rhythms, both physical (circadian, seasonal …) and properly biological (heart beating, respiration, metabolic …). In particular, the role of biological rhythms do not seem to have any counterpart in mathematical formalization of physical clocks, which are based on frequencies along the usual (...) (possibly thermodynamical, thus oriented) time. We then suggest a functional representation of biological time by a 2-dimensional manifold as a mathematical frame for accommodating autonomous biological rhythms. The “visual” representation of rhythms so obtained, in particular heart beatings, will provide, by a few examples, hints towards possible applications of our approach to the understanding of interspecific differences or intraspecific pathologies. The 3- dimensional embedding space, needed for purely mathematical reasons, allows to introduce a suitable extra-dimension for “representation time”, with a cognitive significance. (shrink)

The Kalam Cosmological Argument is perhaps the most solid and widely discussed argument for a caused creation of the universe. The usual objections to the argument mainly focus on the second premise. In this paper we discuss the dependency of the first premise on the topological structure of the space-time manifold adopted for the underlying cosmological model. It is shown that in chronology-violating space-times the first premise can also be violated. The chronology-violation, in turn, requires a massive violation of (...) the so-called energy conditions which might have observational effects that are briefly discussed here. Hence, astronomical observations could be relevant for the validity of the metaphysical argument. In this sense, it is possible to talk of “observational theology”. (shrink)

Introduction: The experience of disconnection is common in first-person accounts of grief. One way in which this feeling of estrangement can manifest is through the splintering apart of the time of the mourner and the time of the world. Supplementing and extending Thomas Fuchs' influential idea of temporal desynchronization, my aim in this article is to give an account of the heterogeneous ways in which grief can disturb time. -/- Method: I organize these manifold experiences of temporal disruption according (...) to a method of "depth analysis": a phenomenological interpretation of temporal desynchronization that tracks the increasing disconnect between the mourner and the world as it manifests in time. In so doing, I draw on a wide range of descriptive first-person responses to the question "Has your experience of time changed in any way?" - included as part of an online questionnaire on the emotional experience of grief conducted recently with colleagues at the University of York. I then stratify these according to a mild, moderate, and profound level of disruption. -/- Results: Before setting out the results of this analysis, I give a background account of Fuchs' interpretation of temporal desynchronization in phenomenological psychopathology more generally and in grief specifically. In my results, I then supplement and extend his interpretation by setting out my phenomenological depth analysis of the increasing disconnect between the time of the mourner and the time of the world, as demonstrated by the questionnaire data. As I argue, such a fine-grained account is an important step in understanding the way time can shape the meaning and significance of different grief experiences. Following this, in my discussion, I demonstrate how a depth approach might be helpful in differentiating between temporal disturbances in a range of affective disorders and give an illustrative comparison of grief and depression. -/- Conclusion: In conclusion, I reflect briefly on what grief might reveal about the depth and complexity of temporal experience itself. In so doing, I consider how the radical disruptions to time in grief might transform the mourner's experience of time irreversibly but in a way that enables a renewed connection to both their deceased loved one and the world from which they have become estranged. (shrink)

Some issues heavily debated in perception sciences are presented: the explanatory gap and the experience measurement problem. The experimental phenomenology is said to provide substantive contribution to settle controversy over the phenome- nological adequacy of perception theory and models. An interpretation of experi- mental phenomenology as explanation of the perceptual manifold, and definition of relation varieties to eventually map onto other perception sciences’ domains is sketched.

Continuing the systematic henadological interpretation of Proclus' Platonic Theology begun in "The Intelligible Gods in the Platonic Theology of Proclus" (Methexis 21, 2008, pp. 131-143), the present article treats of the basic characteristics of intelligible-intellective (or noetico-noeric) multiplicity and its roots in henadic individuality. Intelligible-intellective multiplicity (the hypostasis of Life) is at once a universal organization of Being in its own right, and also transitional between the polycentric henadic manifold, in which each individual is immediately productive of absolute Being, (...) and the formal intellective organization, which is monocentrically and diacritically disposed. Intelligible-intellective multiplicity is generated from the dyadic relationship of henads to their power(s), the phase of henadic individuality expressed in the second intelligible triad, and is mediated, unlike the polycentric manifold, but not by identity and difference, like the intellective organization. Instead, the hypostasis of Life is constituted by ideal motility and spatiality, figural dispositions, and the intersubjective relations depicted in the divine symposium of Plato's Phaedrus. (shrink)