Objective: Lung cancer is the most common cause of morbidity and mortality. Platinum-based chemotherapy, which is the primary line of treatment, offers limited benefit due to drug resistance and side effects. Berberine (BBR), which is characterised by its potent and safe anticancer activity, represents a promising combination option in chemotherapy. To overcome the limitations in lung cancer chemotherapy, we investigated whether BBR and cisplatin (CIS) exert synergistic effects on non-small cell lung cancer cell line (A549) based on cytotoxicity and apoptotic (...) response markers. -/- Methods: The potential cytotoxic effects of the combination treatment were evaluated using the MTT and Chou-Talalay methods. Elisa assays were also performed to measure the levels of the pro-apoptotic protein Bax and the effector protein caspase (Cas)-3. -/- Results: The results showed that BBR alone reduced A549 cell viability in a dose-dependent manner and synergized with CIS (CI =0.34±0.05 at IC50 concentrations). Elisa results showed that the combined treatment (both at IC50 concentrations) modulated apoptotic signalling pathways in A549 cells. Bax and Cas3 protein levels were dramatically enhanced in A549 cells treated with CIS +BBR compared to control (0.5% DMSO) (p < 0.001). -/- Conclusion: Our results suggest that BBR can synergistically enhance the therapeutic effect of CIS in A549 cells. The potential therapeutic efficacy of BBR as part of a combination in current chemotherapy should be supported by in-depth research and clinical studies on the molecular mechanisms associated with cancer. (shrink)

Le XI.ème Congrès International de Philosophie Médiévale de la Société Internationale pour l’Étude de la Philosophie Médiévale (S.I.E.P.M..) s’est déroulé à Porto (Portugal), du 26 au 30 août 2002, sous le thème général: Intellect et Imagination dans la Philosophie Médiévale. A partir des héritages platonicien, aristotélicien, stoïcien, ou néo-platonicien (dans leurs variantes grecques, latines, arabes, juives), la conceptualisation et la problématisation de l’imagination et de l’intellect, ou même des facultés de l’âme en général, apparaissaient comme une ouverture possible pour aborder (...) les principaux points de la pensée médiévale. Les Actes du congrès montrent que « imagination » et « intellect » sont porteurs d’une richesse philosophique extraordinaire dans l’économie de la philosophie médiévale et de la constitution de ses spécificités historiques. Dans sa signification la plus large, la théorisation de ces deux facultés de l’âme permet de dédoubler le débat en au moins six grands domaines: — la relation avec le sensible, où la fantaisie/l’imagination joue le rôle de médiation dans la perception du monde et dans la constitution de la connaissance ; — la réflexion sur l’acte de connaître et la découverte de soi en tant que sujet de pensée ; — la position dans la nature, dans le cosmos, et dans le temps de celui qui pense et qui connaît par les sens externes, internes et par l’intellect ; — la recherche d’un fondement pour la connaissance et l’action, par la possibilité du dépassement de la distante proximité du transcendant, de l’absolu, de la vérité et du bien ; — la réalisation de la félicité en tant qu’objectif ultime, de même que la découverte d’une tendance au dépassement actif ou mystique de toutes les limites naturelles et des facultés de l’âme ; — la constitution de théories de l’image, sensible ou intellectuelle, et de ses fonctions. Les 3 volumes d’Actes incluent les 16 leçons plénières et 112 communications, ainsi que les index correspondants (manuscrits ; noms anciens et médiévaux ; noms modernes ; auteurs). Le volume IV des Actes, contenant 39 communications et des index, est publié par la revue " Mediaevalia. Textos e Estudos ", du Gabinete de Filosofia Medieval de l’Universidade do Porto (volume 23, de 2004). Ouvrage publié avec l’appui de l’Universidade do Porto, de la Faculdade de Letras da U.P., du Departamento de Filosofia - F.L.U.P. et de la Fundação para a Ciência e a Tecnologia (Portugal). (shrink)

This paper aims at analysing, in a phenomenological perspective, how meaning occurs in literary readings as well as in literary discussions. The study takes as its empirical starting point a seminar session, in which several academic readers have shared their experiences of the same novel. It appeared that the constitution of the novel's meaning was modified and continued during the discussion and, therefore, that the meaning of the novel was not available before the discussion happened. Then, to understand what happened (...) before the discussion, the inquiry relies on P. Bayard's theoretical elaborations, which state that the solitary experience of reading itself involves previous readings: the subjectivity of the reader is haunted by a plurality of texts, virtually involved in the process of reading of the novel. Therefore, the article intends to explore the notion of potential space, coined by Winnicott, and to define it as an intersubjective space, made of virtual subjectivities. Ultimately, to describe the way a new meaning has arisen between the participants, the study relies on M. Richir's phenomenology. The point, here, is to question the actual but unconscious interweaving of the subjectivities in the discussion. Thus, the study provides a deeper understanding of the creativity of the act of reading, by assuming that creativity cannot happen without a plurality of subjectivities, existing or virtual. (shrink)

Élie HALÉVY (1870-1937), philosophe et historien des idées, fut professeur à l'École libre des sciences politiques, l'ancêtre de l'actuel Sciences Po. Comme son autre grand ouvrage, l'Histoire du peuple anglais au XIXe siècle, paru en six tomes de 1913 à 1932, les trois tomes de La formation du radicalisme philosophique, parus en 1901 pour les deux premiers et en 1904 pour le troisième, reflètent pour partie ses enseignements de l'Ecole libre consacrés à l'histoire britannique. Le premier tome, La jeunesse de (...) Bentham 1776-1789, étudie la doctrine utilitariste non seulement chez celui qu'on regarde comme son fondateur principal, Jeremy Bentham, mais aussi chez les nombreux auteurs qui, en Grande-Bretagne et sur le continent, en dessinèrent avant lui les contours. Le deuxième tome, L’évolution de la doctrine utilitaire de 1789 à 1815, montre comment l'utilitarisme revêtit la forme non seulement d'une école de pensée, mais aussi d'un mouvement pour la réforme économique, sociale et politique. Le rôle coordonnateur nouveau de James Mill, ainsi qu'une convergence de vues avec les économistes, qui poussaient dans le sens des réformes, marquèrent notamment cette évolution. Le troisième tome, Le radicalisme philosophique, continue d'étudier la transformation de l'école en mouvement après la fin des guerres napoléoniennes, lorsque celle-ci commence à engranger ses premiers grands succès réformistes. Bentham, James Mill et les autres penseurs utilitaires sont alors réunis sous l'appellation de philosophic radicals. Le terme temporel de l'ouvrage est le Reform Act de 1832, première étape vers la modernisation du système électoral, que la propagande de ce groupe ne contribua pas peu à faire aboutir. Quoique l'ouvrage d'Halévy vaille en premier lieu par l'immense savoir qu'il déploie, et le nombre et l'excellence des citations qu'il propose, il comporte aussi des thèses historiques et philosophiques originales. On peut citer parmi les premières la thèse, qui relie les trois tomes, voulant que l'utilitarisme britannique trouve sa forme achevée dans l'intervention sur la société, lorsqu'il se mue en radicalisme philosophique, et parmi les secondes, la thèse, énoncée au début du premier tome, voulant qu'il existe trois modèles dominants de jonction des intérêts individuels (la fusion sympathique, l'identification naturelle et l'identification artificielle). Une autre grande thèse, à la fois historique et philosophique, affirme en substance que l'économie politique classique serait un département spécialisé de la pensée utilitaire. La question de savoir jusqu'à quel point Smith, Ricardo et Malthus ont pu adhérer au "principe d'utilité" de Bentham est toujours débattue. En même temps que les élucidations apportées à ce principe, elle contribue à expliquer l'intérêt que les historiens de la pensée économique continuent de porter à l'ouvrage. L'auteur a participé à la réédition de La formation du radicalisme philosophique en 1995 par les Presses Universitaires de France (P.U.F.), suivant un projet collectif lancé par Monique Canto-Sperber. Dans le présent article, antérieur à cette réédition, l'auteur tentait de résumer brièvement un livre qui demeure irremplaçable en dépit d'une conception et d'un style quelque peu datés. (shrink)

LEITE (Fábio Rodrigo) – STOFFEL (Jean-François), Introduction (pp. 3-6). BARRA (Eduardo Salles de O.) – SANTOS (Ricardo Batista dos), Duhem’s analysis of Newtonian method and the logical priority of physics over metaphysics (pp. 7-19). BORDONI (Stefano), The French roots of Duhem’s early historiography and epistemology (pp. 20-35). CHIAPPIN (José R. N.) – LARANJEIRAS (Cássio Costa), Duhem’s critical analysis of mecha­ni­cism and his defense of a formal conception of theoretical phy­sics (pp. 36-53). GUEGUEN (Marie) – PSILLOS (Stathis), Anti-­scepticism and epistemic humility (...) in Pierre Duhem’s philosophy of science (pp. 54-72). LISTON (Michael), Duhem : images of science, historical continuity, and the first crisis in physics (pp. 73-84). MAIOCCHI (Roberto), Duhem in pre-war Italian philos­ophy : the reasons of an absence (pp. 85-92). HERNÁNDEZ MÁRQUEZ (Víctor Manuel), Was Pierre Duhem an «esprit de finesse» ? (pp. 93-107). NEEDHAM (Paul), Was Duhem justified in not distinguishing between physical and chemical atomism ? (pp. 108-111). OLGUIN (Roberto Estrada), «Bon sens» and «noûs» (pp. 112-126). OLIVEIRA (Amelia J.), Duhem’s legacy for the change in the historiography of science : An analysis based on Kuhn’s writings (pp. 127-139). PRÍNCIPE (João), Poincaré and Duhem : Resonances in their first epistemological reflec­tions (pp. 140-156). MONDRAGON (Damián Islas), Book review of «Pierre Duhem : entre física y metafísica» (pp. 157-159). STOFFEL (Jean-François), Book review of P. Duhem : «La théorie physique : son objet, sa structure» / edit. by S. Roux (pp. 160-162). STOFFEL (Jean-François), Book review of St. Bordoni : «When historiography met epistemology» (pp. 163-165). (shrink)

Olen laatinut tämän kirjoituksen vastineeksi J.P. Roosin poleemiseen kirjoitukseen, jonka hän on lehtien hylättyä sen julkaissut omalla kotisivullaan.

Cet article se penche sur le rapport de la conception républicaine de la liberté comme non-domination défendue par P. Pettit avec la conception de la liberté comme capabilité proposée par A. Sen. L’usage que fait Pettit de la conception défendue par Sen lui permet d’avancer une conception plus réaliste des préférences des individus en contexte social. Cette définition des « préférences décisives » guide toute sa démonstration de la compatibilité de la liberté comme capabi- lité avec la théorie néorépublicaine. Elle (...) lui permet en outre de donner une valeur particulière à l’objectif social de lutte contre la précarité, précarité comprise comme situation dans laquelle un individu est placé sous la dépendance arbitraire d’un autre en l’empêchant de se mouvoir à sa guise dans le jeu social. Nous examinons les enjeux de cette articulation à la lumière de la réponse critique qui a été formulée par Sen à l’effet que la conception néorépublicaine limitait trop la pluralité sociale de la liberté. Enfin, nous esquissons une manière de réconcilier l’approche par les capabilités avec la conception républicaine. (shrink)

D’après Heidegger, chaque époque/épochè est caractérisé par un certain mode de révélation des étants, qui est à la fois une dissimulation d’une façon de l’Être. Ce mode particulier paraît ne venir de nulle part en ce qu’il se base sur un certain oubli. Dana S. Belu le met en scène pour son livre en faisant valoir la tendance de Heidegger « to treat the history of being (Seinsgeschichte) as a noncausal succession of universal principles of intelligibility that presupposes the forgetting (...) (Seinsvergessenheit) of the clearing (die Lichtung) as their source » (p. 15). L’oubli de notre époque est marqué par une divulgation technologique dans le mode de l’arraisonnement (Gestell) où les étants se révèlent comme partie du fonds (Bestand) d’être calculés, manipulés, exploités, et mis en réserve pour un usage ultérieur. La phénoménologie féministe de l’A. essaie de faire sens à la gestation, la maternité et la procréation médicalement assistée (PMA) qui font aux femmes faire partie de ce fonds et ouvre, parmi les paramètres du Gestell, la porte à une ère « sans mère ». (shrink)

This is a transcript of a conversation between P F Strawson and Gareth Evans in 1973, filmed for The Open University. Under the title 'Truth', Strawson and Evans discuss the question as to whether the distinction between genuinely fact-stating uses of language and other uses can be grounded on a theory of truth, especially a 'thin' notion of truth in the tradition of F P Ramsey.

Là một nhà nghiên cứu kinh tế có nhiều thành tựu, một trong các nhà khoa học có chỉ số các bài báo khoa học được công bố quốc tế cao nhất cả nước, TS Vương Quân Hoàng (Trường ĐH Phenikaa) đã chia sẻ cùng Nhân Dân hằng tháng những quan điểm cá nhân về một năm kinh tế nhiều dấu ấn của đất nước.

This dissertation examines the practice of categorizing works of art and its relationship to art criticism. How a work of art is categorized influences how it is appreciated and criticized. Being frightening is a merit for horror, but a demerit for lullabies. The brushstrokes in Monet's "Impression, Sunrise" (1874) look crude when seen as a Neoclassical painting, but graceful when seen as an Impressionist painting. Many of the judgments we make about artworks are category-dependent in this way, but previous research (...) has rarely examined in depth the ontological structure of art categories, how they are generated and maintained, and how they function. This dissertation fills this gap. The proposal of this dissertation can be summarized as follows. Categories (especially genres) should be analyzed as clusters of rules that regulate the responses and behaviors of agents in the artworld. The visual mundaneness is a critical reason to consider Duchamp's "Comb" (1916) provocative, given the existence of the readymade as a set of rules that justifies such reasoning. The critical and appreciative practice of which categorization is a part is a social practice of making, declaring, proposing, reforming, and developing rules of appreciation. How we appreciate artworks, and how criticism guides our appreciation, is sensitive to how we categorize artworks. How we categorize artworks is sensitive to what categories have been set up in our community and which categories are active regarding each artwork. (shrink)

It is widely acknowledged that categories play significant roles in the appreciation of artworks. This paper argues that the correct categories of artworks are institutionally established through social processes. Section 1 examines the candidates for determining correct categories and proposes that this question should shift the focus from category membership to appreciative behaviour associated with categories. Section 2 draws on Francesco Guala’s theory of institutions to show that categories of artworks are established as rules-in-equilibrium. Section 3 reviews the explanatory benefits (...) of this institutional theory of the correct category. [Winner of the 2022 Debates in Aesthetics Essay Prize]. (shrink)

Hal pertama yang harus kita ingat adalah bahwa ketika mengatakan bahwa Cina mengatakan ini atau Cina melakukan itu, kita tidak berbicara tentang orang-orang Cina, tetapi dari Sosiopat yang mengendalikan PKT - Partai Komunis Cina, yaitu, Tujuh Pikun Sosiopat Pembunuh Berantai (SSSSK) dari Komite Tetap PKT atau 25 anggota Politbiro dll. Rencana PKT untuk WW3 dan dominasi total ditata cukup jelas dalam publikasi dan pidato pemerintah Cina dan ini adalah "China Dream" Xi Jinping. Ini adalah mimpi hanya untuk minoritas kecil (mungkin (...) beberapa lusin sampai beberapa ratus) yang memerintah Cina dan mimpi buruk bagi orang lain (termasuk 1,4 miliar Cina). 10 miliar dolar per tahun memungkinkan mereka atau boneka mereka untuk memiliki atau mengontrol surat kabar, majalah, saluran TV dan radio dan menempatkan berita palsu di sebagian besar media utama di mana-mana setiap hari. Selain itu, mereka memiliki tentara (mungkin jutaan orang) yang troll semua media menempatkan lebih banyak propaganda dan menenggelamkan komentar yang sah (tentara 50 sen). Selain melucuti sumber daya dunia ke-3, dorongan utama Belt and Road Initiative multi-triliun dolar adalah membangun pangkalan militer di seluruh dunia. Mereka memaksa dunia bebas menjadi perlombaan senjata berteknologi tinggi besar-besaran yang membuat perang dingin dengan Uni Soviet tampak seperti piknik. Meskipun SSSSK, dan seluruh militer dunia, menghabiskan jumlah besar pada perangkat keras canggih, sangat mungkin bahwa WW3 (atau keterlibatan yang lebih kecil menjelang itu) akan didominasi perangkat lunak. Hal ini tidak keluar dari pertanyaan bahwa SSSSK, dengan mungkin lebih hacker (coders) bekerja untuk mereka maka seluruh dunia digabungkan, akan memenangkan perang masa depan dengan konflik fisik minimal, hanya dengan melumpuhkan musuh mereka melalui internet. Tidak ada satelit, tidak ada telepon, tidak ada komunikasi, tidak ada transaksi keuangan, tidak ada jaringan listrik, tidak ada internet, tidak ada senjata canggih, tidak ada kendaraan, kereta api, kapal atau pesawat. Hanya ada dua jalan utama untuk menghapus PKT, membebaskan 1,4 miliar tahanan Cina, dan mengakhiri pawai gila ke WW3. Yang damai adalah untuk meluncurkan perang dagang habis-habisan untuk menghancurkan ekonomi Cina sampai militer muak dan sepatu bot keluar PKT. Alternatif untuk mematikan ekonomi Cina adalah perang terbatas, seperti pemogokan yang ditargetkan dengan mengatakan 50 drone termobarik pada Kongres KE-20th PKT, ketika semua anggota top berada di satu tempat, tetapi itu tidak akan terjadi sampai 2022 sehingga seseorang bisa mencapai rapat pleno tahunan. Cina akan diberitahu, sebagai serangan terjadi, bahwa mereka harus meletakkan lengan mereka dan mempersiapkan diri untuk mengadakan pemilihan demokratis atau nuked ke zaman batu. Alternatif lainnya adalah serangan nuklir habis-habisan. Konfrontasi militer tidak dapat dihindari mengingat kursus PKT saat ini. Ini kemungkinan akan terjadi di atas pulau-pulau di Laut Cina Selatan atau Taiwan dalam beberapa dekade, tetapi ketika mereka mendirikan pangkalan militer di seluruh dunia itu bisa terjadi di mana saja (lihat Crouching Tiger dll).). Konflik di masa depan akan memiliki aspek hardkill dan softkill dengan tujuan yang dinyatakan dari PKT untuk menekankan perang siber dengan meretas dan melumpuhkan sistem kontrol dari semua komunikasi militer dan industri, peralatan, pembangkit listrik, satelit, internet, bank, dan perangkat atau kendaraan apa pun yang terhubung ke internet. SS perlahan-lahan fielding array di seluruh dunia berawak dan otonom permukaan dan bawah air kapal selam atau drone mampu meluncurkan senjata konvensional atau nuklir yang mungkin tertidur menunggu sinyal dari Cina atau bahkan mencari tanda tangan kapal ATAU pesawat AS. Sementara menghancurkan satelit kami, sehingga menghilangkan komunikasi antara Amerika Serikat dan pasukan kami di seluruh dunia, mereka akan menggunakan mereka, dalam hubungannya dengan drone untuk menargetkan dan menghancurkan angkatan laut kita saat ini unggul. Tentu saja, semua ini semakin dilakukan secara otomatis oleh AI. Sejauh ini sekutu terbesar PKT adalah partai Demokrat amerika serikat. Pilihannya adalah untuk menghentikan PKT sekarang atau menonton saat mereka memperpanjang penjara Cina di seluruh dunia. Tentu saja, pengawasan universal dan digitalisasi kehidupan kita tidak dapat dihindari di mana-mana. Siapa pun yang tidak berpikir begitu sangat tidak berhubungan. Tentu saja itu adalah optimists yang mengharapkan sosiopat Cina untuk memerintah dunia sementara pesimis (yang melihat diri mereka sebagai realis) mengharapkan sosiopati AI (atau AS seperti yang saya sebut - yaitu, Artificial Stupidity atau Artificial Sociopathy) untuk mengambil alih, mungkin pada tahun 2030 Mereka yang tertarik pada rincian lebih lanjut tentang jalan gila masyarakat modern dapat berkonsultasi dengan karya-karya saya yang lain seperti Suicide by Democracy-an Obituary for America and the World 3rd Edition 2019 and Suicidal Utopian Delusions in the 21st Century: Philosophy, Human Nature and the Collapse of Civilization 5th ed (2019). (shrink)

Decentralising Bengaluru Urban -The Regional Planning way -/- Author / Authors : Priyadarshini Sen Page no.139 -148 Discipline : Applied Economics/ Management/ Commerce/Geography Script/language : Roman/English Category : Research paper Keywords: Regional Planning, Metropolis, Social wellbeing, Settlement.

Some scientific categories seem to correspond to genuine features of the world and are indispensable for successful science in some domain; in short, they are natural kinds. This book gives a general account of what it is to be a natural kind and puts the account to work illuminating numerous specific examples.

Tradução para o português do livro "Ceticismo e naturalismo: algumas variedades", Strawson, P. F. . São Leopoldo, RS: Editora da Unisinos, 2008, 114 p. Coleção: Ideias. ISBN: 9788574313214. Capítulo 1 - Ceticismo, naturalismo e argumentos transcendentais 1. Notas introdutórias; 2. Ceticismo tradicional; 3. Hume: Razão e Natureza; 4. Hume e Wittgenstein; 5. “Apenas relacionar”: O papel dos argumentos transcendentais; 6. Três citações; 7. Historicismo: e o passado.

forall x: Calgary is a full-featured textbook on formal logic. It covers key notions of logic such as consequence and validity of arguments, the syntax of truth-functional propositional logic TFL and truth-table semantics, the syntax of first-order (predicate) logic FOL with identity (first-order interpretations), symbolizing English in TFL and FOL, and Fitch-style natural deduction proof systems for both TFL and FOL. It also deals with some advanced topics such as modal logic, soundness, and functional completeness. Exercises with solutions are available. (...) It is provided in PDF (for screen reading, printing, and a special version for dyslexics), HTML, and in LaTeX source code. (shrink)

The notion of a simulating termination analyzer is examined at the concrete level of pairs of C functions. This is similar to AProVE: Non-Termination Witnesses for C Programs. The termination status decision is made on the basis of the dynamic behavior of the input. This paper explores what happens when a simulating termination analyzer is applied to an input that calls itself.

Do the ethical features of an artwork bear on its aesthetic value? This movie endorses misogyny, that song is a civil rights anthem, the clay constituting this statue was extracted with underpaid labor—are facts like these the proper bases for aesthetic evaluation? I argue that this debate has suffered from a false presupposition: that if the answer is yes (for at least some such ethical features), such considerations feature as pro tanto contributions to an artwork's overall aesthetic value, i.e., as (...) merits or flaws which make something have more or less overall aesthetic value. As the case of ethically laden, aesthetic evaluation makes clear, however, good aesthetic judgement is irreducibly multi-dimensional, e.g., "the movie has an engaging soundtrack, tasteful camera work, and takes a misogynistically prurient perspective on its female lead.'' Such a "non-summative" judgement refuses to reduce those various dimensions of aesthetic value to a single aggregate aesthetic evaluation, like "it's a 6/10" or "it's a pretty good movie!" I defend both the modest claim that such non-summative evaluations are not mistaken and the extremist claim that summative (i.e., unidimensional) aesthetic evaluation is defective by considering other domains of normative assessment in which summing seems inappropriate, notably including evaluations of people's character. (shrink)

There is a history of thinking that photographs provide a special kind of access to the objects depicted in them, beyond the access that would be provided by a painting or drawing. What is included in the photograph does not depend on the photographer’s beliefs about what is in front of the camera. This feature leads Kendall Walton to argue that photographs literally allow us to see the objects which appear in them. Current generative algorithms produce images in response to (...) users’ text prompts. Depending on the parameters, the output can resemble specific people or things which are named in the prompt. This resemblance does not depend on the user’s beliefs, so generated images are in this sense like photographs. Given this parallel, how should we think about AI-generated images? (shrink)

I've previously suggested that the historical evidence used to challenge scientific realism should lead us to embrace what I call Uniformitarianism, but many recently influential forms of scientific realism seem happy to share this commitment. I trace a number of further points of common ground that collectively constitute an appealing Middle Path between classical forms of realism and instrumentalism, and I suggest that many contemporary realists and instrumentalists have already become fellow travelers on this Middle Path without recognizing how far (...) they have thereby diverged from those who share their labels and slogans. I conclude by describing their central remaining disagreement and the sorts of evidence needed to resolve it. (shrink)

A critical note on Christopher Bartel and Jack M. C. Kwong, ‘Pluralism, Eliminativism, and the Definition of Art’, Estetika 58 (2021): 100–113. Art pluralism is the view that there is no single, correct account of what art is. Instead, art is understood through a plurality of art concepts and with considerations that are different for particular arts. Although avowed pluralists have retained the word ‘art’ in their discussions, it is natural to ask whether the considerations that motivate pluralism should lead (...) us to abandon art talk altogether; that is, should pluralism lead to eliminativism? This paper addresses arguments both for and against this move. We ultimately argue that pluralism allows one to retain the word ‘art’, if one wants it, but only in a loose, conversational sense. The upshot of pluralism is that talk of art in general cannot be asked to do theoretical and philosophical work. (shrink)

William James’ argument against William Clifford in The Will to Believe is often understood in terms of doxastic efficacy, the power of belief to influence an outcome. Although that is one strand of James’ argument, there is another which is driven by ampliative risk. The second strand of James’ argument, when applied to scientific cases, is tantamount to what is now called the Argument from Inductive Risk. Either strand of James’ argument is sufficient to rebut Clifford's strong evidentialism and show (...) that it is sometimes permissible to believe in the absence of compelling evidence. However, the two considerations have different scope and force. Doxastic efficacy applies in only some cases but allows any values to play a role in determining belief; risk applies in all cases but only allows particular conditional values to play a role. (shrink)

P. F. Strawson; II*—Scruton and Wright on Anti-Realism Etc., Proceedings of the Aristotelian Society, Volume 77, Issue 1, 1 June 1977, Pages 15–22, https://doi.

The no-miracles argument and the pessimistic induction are arguably the main considerations for and against scientific realism. Recently these arguments have been accused of embodying a familiar, seductive fallacy. In each case, we are tricked by a base rate fallacy, one much-discussed in the psychological literature. In this paper we consider this accusation and use it as an explanation for why the two most prominent `wholesale' arguments in the literature seem irresolvable. Framed probabilistically, we can see very clearly why realists (...) and anti-realists have been talking past one another. We then formulate a dilemma for advocates of either argument, answer potential objections to our criticism, discuss what remains (if anything) of these two major arguments, and then speculate about a future philosophy of science freed from these two arguments. In so doing, we connect the point about base rates to the wholesale/retail distinction; we believe it hints at an answer of how to distinguish profitable from unprofitable realism debates. In short, we offer a probabilistic analysis of the feeling of ennui afflicting contemporary philosophy of science. (shrink)

The Argument from Inductive Risk (AIR) is taken to show that values are inevitably involved in making judgements or forming beliefs. After reviewing this conclusion, I pose cases which are prima facie counterexamples: the unreflective application of conventions, use of black-boxed instruments, reliance on opaque algorithms, and unskilled observation reports. These cases are counterexamples to the AIR posed in ethical terms as a matter of personal values. Nevertheless, it need not be understood in those terms. The values which load a (...) theory choice may be those of institutions or past actors. This means that the challenge of responsibly handling inductive risk is not merely an ethical issue, but is also social, political, and historical. (shrink)

When we ask what natural kinds are, there are two different things we might have in mind. The first, which I’ll call the taxonomy question, is what distinguishes a category which is a natural kind from an arbitrary class. The second, which I’ll call the ontology question, is what manner of stuff there is that realizes the category. Many philosophers have systematically conflated the two questions. The confusion is exhibited both by essentialists and by philosophers who pose their accounts in (...) terms of similarity. It also leads to misreading philosophers who do make the distinction. Distinguishing the questions allows for a more subtle understanding of both natural kinds and their underlying metaphysics. (shrink)

Philosophy in Africa has for more than a decade now been dominated by the discussion of one compound question, namely, is there an African philosophy, and if there is, what is it? The first part of the question has generally been unhesitatingly answered in the affirmative. Dispute has been primarily over the second part of the question as various specimens of African philosophy presented do not seem to pass muster. Those of us who refuse to accept certain specimens as philosophy (...) have generally been rather illogically said also to deny an affirmative answer to the first part of the question. In a paper presented at the International Symposium in Memory of Dr William Amo, the Ghanaian philosopher who taught in German universities in the early part of the eighteenth century, Professor Odera Oruka identified four trends, perhaps more appropriately approaches, in current African philosophy. (shrink)

Imperatives cannot be true, but they can be obeyed or binding: `Surrender!' is obeyed if you surrender and is binding if you have a reason to surrender. A pure declarative argument — whose premisses and conclusion are declaratives — is valid exactly if, necessarily, its conclusion is true if the conjunction of its premisses is true; similarly, I suggest, a pure imperative argument — whose premisses and conclusion are imperatives — is obedience-valid (alternatively: bindingness-valid) exactly if, necessarily, its conclusion is (...) obeyed (alternatively: binding) if the conjunction of its premisses is. I argue that there are two kinds of bindingness, and that a vacillation between two corresponding variants of bindingness-validity largely explains conflicting intuitions concerning the validity of some pure imperative arguments. I prove that for each of those two variants of bindingness-validity there is an equivalent variant of obedience-validity. Finally, I address alternative accounts of pure imperative inference. (shrink)

The accepted narrative treats John Stuart Mill’s Kinds as the historical prototype for our natural kinds, but Mill actually employs two separate notions: Kinds and natural groups. Considering these, along with the accounts of Mill’s nineteenth-century interlocutors, forces us to recognize two distinct questions. First, what marks a natural kind as worthy of inclusion in taxonomy? Second, what exists in the world that makes a category meet that criterion? Mill’s two notions offer separate answers to the two questions: natural groups (...) for taxonomy and Kinds for ontology. This distinction is ignored in many contemporary debates about natural kinds and is obscured by the standard narrative that treats our natural kinds just as a development of Mill’s Kinds. (shrink)

The problem of underdetermination is thought to hold important lessons for philosophy of science. Yet, as Kyle Stanford has recently argued, typical treatments of it offer only restatements of familiar philosophical problems. Following suggestions in Duhem and Sklar, Stanford calls for a New Induction from the history of science. It will provide proof, he thinks, of “the kind of underdetermination that the history of science reveals to be a distinctive and genuine threat to even our best scientific theories” (Stanford 2001, (...) p. S12). This paper examines Stanford’s New Induction and argues that it – like the other forms of underdetermination that he criticizes – merely recapitulates familiar philosophical conundra. (shrink)

There are two senses of ‘what scientists know’: An individual sense (the separate opinions of individual scientists) and a collective sense (the state of the discipline). The latter is what matters for policy and planning, but it is not something that can be directly observed or reported. A function can be defined to map individual judgments onto an aggregate judgment. I argue that such a function cannot effectively capture community opinion, especially in cases that matter to us.

Homeostatic property clusters (HPCs) are offered as a way of understanding natural kinds, especially biological species. I review the HPC approach and then discuss an objection by Ereshefsky and Matthen, to the effect that an HPC qua cluster seems ill-fitted as a description of a polymorphic species. The standard response by champions of the HPC approach is to say that all members of a polymorphic species have things in common, namely dispositions or conditional properties. I argue that this response fails. (...) Instances of an HPC kind need not all be similar in their exhibited properties. Instead, HPCs should instead be understood as unified by the underlying causal mechanism that maintains them. The causal mechanism can both produce and explain some systematic differences between a kind’s members. An HPC kind is best understood not as a single cluster of properties maintained in stasis by causal forces, but as a complex of related property clusters kept in relation by an underlying causal process. This approach requires recognizing that taxonomic systems serve both explanatory and inductive purposes. (shrink)

According to the standard narrative, natural kind is a technical notion that was introduced by John Stuart Mill in the 1840s and the recent craze for natural kinds, launched by Putnam and Kripke, is a continuation of that tradition. I argue that the standard narrative is mistaken. The Millian tradition of kinds was not particularly influential in the 20th-century, and the Putnam-Kripke revolution did not clearly engage with even the remnants that were left of it. The presently active tradition of (...) natural kinds is less than half a century old. Recognizing this might help us better appreciate both Mill and natural kinds. (shrink)

Given the fact that many people use Wikipedia, we should ask: Can we trust it? The empirical evidence suggests that Wikipedia articles are sometimes quite good but that they vary a great deal. As such, it is wrong to ask for a monolithic verdict on Wikipedia. Interacting with Wikipedia involves assessing where it is likely to be reliable and where not. I identify five strategies that we use to assess claims from other sources and argue that, to a greater of (...) lesser degree, Wikipedia frustrates all of them. Interacting responsibly with something like Wikipedia requires new epistemic methods and strategies. (shrink)

Although some authors hold that natural kinds are necessarily relative to disciplinary domains, many authors presume that natural kinds must be absolute, categorical features of the reality —often assuming that without even mentioning the alternative. Recognizing both possibilities, one may ask whether the difference especially matters. I argue that it does. Looking at recent arguments about natural kind realism, I argue that we can best make sense of the realism question by thinking of natural kindness as a relation that holds (...) between a category and a domain. (shrink)

It is now commonly held that values play a role in scientific judgment, but many arguments for that conclusion are limited. First, many arguments do not show that values are, strictly speaking, indispensable. The role of values could in principle be filled by a random or arbitrary decision. Second, many arguments concern scientific theories and concepts which have obvious practical consequences, thus suggesting or at least leaving open the possibility that abstruse sciences without such a connection could be value-free. Third, (...) many arguments concern the role values play in inferring from evidence, thus taking evidence as given. This paper argues that these limitations do not hold in general. There are values involved in every scientific judgment. They cannot even conceivably be replaced by a coin toss, they arise as much for exotic as for practical sciences, and they are at issue as much for observation as for explicit inference. (shrink)

Kyle Stanford has recently claimed to offer a new challenge to scientific realism. Taking his inspiration from the familiar Pessimistic Induction (PI), Stanford proposes a New Induction (NI). Contra Anjan Chakravartty’s suggestion that the NI is a ‘red herring’, I argue that it reveals something deep and important about science. The Problem of Unconceived Alternatives, which lies at the heart of the NI, yields a richer anti-realism than the PI. It explains why science falls short when it falls short, and (...) so it might figure in the most coherent account of scientific practice. However, this best account will be antirealist in some respects and about some theories. It will not be a sweeping antirealism about all or most of science. (shrink)

The Homeostatic Property Cluster (HPC) account of natural kinds has become popular since it was proposed by Richard Boyd in the late 1980s. Although it is often taken as a defining natural kinds as such, it is easy enough to see that something's being a natural kind is neither necessary nor sufficient for its being an HPC. This paper argues that it is better not to understand HPCs as defining what it is to be a natural kind but instead as (...) providing the ontological realization of (some) natural kinds. (shrink)

This paper gives a characterization of distributed cognition (d-cog) and explores ways that the framework might be applied in studies of science. I argue that a system can only be given a d-cog description if it is thought of as performing a task. Turning our attention to science, we can try to give a global d-cog account of science or local d-cog accounts of particular scientific projects. Several accounts of science can be seen as global d-cog accounts: Robert Merton's sociology (...) of scientific norms, Philip Kitcher's 20th-century account of cognitive labor, and Kitcher's 21st-century notion of well-ordered science. Problems that arise for them arise just because of the way that they attribute a function to science. The paper concludes by considering local d-cog accounts. Here, too, the task is the crux of the matter. (shrink)

The underdetermination of theory by evidence is supposed to be a reason to rethink science. It is not. Many authors claim that underdetermination has momentous consequences for the status of scientific claims, but such claims are hidden in an umbra of obscurity and a penumbra of equivocation. So many various phenomena pass for `underdetermination' that it's tempting to think that it is no unified phenomenon at all, so I begin by providing a framework within which all these worries can be (...) seen as species of one genus: A claim of underdetermination involves (at least implicitly) a set of rival theories, a standard of responsible judgment, and a scope of circumstances in which responsible choice between the rivals is impossible. Within this framework, I show that one variety of underdetermination motivated modern scepticism and thus is a familiar problem at the heart of epistemology. I survey arguments that infer from underdetermination to some reëvaluation of science: top-down arguments infer a priori from the ubiquity of underdetermination to some conclusion about science; bottom-up arguments infer from specific instances of underdetermination, to the claim that underdetermination is widespread, and then to some conclusion about science. The top-down arguments either fail to deliver underdetermination of any great significance or (as with modern scepticism) deliver some well-worn epistemic concern. The bottom-up arguments must rely on cases. I consider several promising cases and find them to either be so specialized that they cannot underwrite conclusions about science in general or not be underdetermined at all. Neither top-down nor bottom-up arguments can motivate any deep reconsideration of science. (shrink)

Tradução para o português do ensaio "Freedom and Resentment”, de P. F. Strawson. Publicado originalmente em Proceedings of the British Academy, v. 48, 1960. Republicado em Freedom and Resentment and Other Essays. Londres: Methuen, 1974. [Routledge, 2008, p. 2-28]. Publicado na coletânea: Ensaios sobre a filosofia de Strawson: com a tradução de Liberdade e ressentimento & Moralidade social e ideal individual. Organizadores: Jaimir Conte & Itamar Luís Gelain. Editora da UFSC, 2015. ISBN: 9788532807250.

Tradução para o português do ensaio "Social Morality and Individual Ideal”. Publicado originalmente em Philosophy: The Journal of the Royal Institute of Philosophy, vol. XXXVI, n. 136, p. 1-17, Jan. 1961. Republicado em: STRAWSON, P. F. Freedom and Resentment and Other Essays. Londres: Methuen, 1974. [Routledge, 2008, p. 26-44]. ]. Publicado na coletânea: Ensaios sobre a filosofia de Strawson: com a tradução de Liberdade e ressentimento & Moralidade social e ideal individual. Organizadores: Jaimir Conte & Itamar Luís Gelain. Editora da (...) UFSC, 2015. ISBN: 9788532807250. (shrink)

"This self-consistent evolution of the fragments, their causal relationships, and their quantum properties is at the heart of the FCQG-SM framework, providing a unified description of quantum mechanics, general relativity, and the Standard Model.".

Some philosophers understand natural kinds to be the categories which are constraints on enquiry. In order to elaborate the metaphysics appropriate to such an account, I consider the complicated history of scurvy, citrus, and vitamin C. It may be tempting to understand these categories in a shallow way (as mere property clusters) or in a deep way (as fundamental properties). Neither approach is adequate, and the case instead calls for middle-range ontology: starting from categories which we identify in the world (...) and elaborating their structure, but not pretending to jump ahead to a complete story about fundamental being. (shrink)

In this paper, I reply to 18 of the essays on panpsychism in this issue. Along the way, I sketch out what a post-Galilean science of consciousness, one in which consciousness is taken to be a fundamental feature of reality, might look like.

A considerable literature has grown up around the claim of Uniqueness, according to which evidence rationally determines belief. It is opposed to Permissivism, according to which evidence underdetermines belief. This paper highlights an overlooked third possibility, according to which there is no rational doxastic attitude. I call this 'Nihilism'. I argue that adherents of the other two positions ought to reject it but that it might, nevertheless, obtain at least sometimes.

Pekakak adalah salah satu tokoh yang memiliki pengetahuan mendalam dan perencanaan yang cermat. Saat fajar menyingsing, ia terlihat bertengger di atas pohon. Dengan kemampuan sempurna untuk mengontrol kecepatan penerbangan miliknya, seperti kapan harus memperlambat atau mempercepat, dia dapat dengan mudah menghitung cara optimal untuk menangkap ikan.

This note outlines a Theory of Everything consistent with the PF interpretation of quantum mechanics.