Wilfrid Sellars’ denunciation of the Myth of the Given was meant to clarify, against empiricism, that perceptual episodes alone are insufficient to ground and justify perceptual knowledge. Sellars showed that in order to accomplish such epistemic tasks, more resources and capacities, such as those involved in using concepts, are needed. Perceptual knowledge belongs to the space of reasons and not to an independent realm of experience. Dan Hutto and Eric Myin have recently presented the Hard Problem of Content as an (...) ensemble of reasons against naturalistic accounts of content. In a nutshell, it states that covariance relations—even though they are naturalistically acceptable explanatory resources—do not constitute content. The authors exploit this move in order to promote their preferred radical enactivist and anti-representationalist option, according to which, basic minds—the lower stratum of cognition—do not involve content. Although it is controversial to argue that the Hard Problem of Content effectively dismisses naturalistic theories of representation, a central aspect of it—the idea that information as covariance does not suffice to explain content—finds support among the defenders of classical cognitive representationalism, such as Marcin Miłkowski. This support—together with the acknowledgment this remark about covariance is a point already made by Sellars in his criticism of the Myth of the Given—has a number of interesting implications. Not only is it of interest for the debates about representationalism in cognitive science, where it can be understood as an anticipatory move, but it also offers some clues and insights for reconsidering some issues along Sellarsian lines—a conflation between two concepts of representation that is often assumed in cognitive science, a distinction between two types of relevant normativities, and a reconsideration of the naturalism involved in such explanations. (shrink)

The paper provides both a description of conspiracy beliefs and an insight into their cultural significance. On one side, it highlights their specific formal features, on the other, and this constitutes its peculiarity in the recent literature on the topic, it considers them within the broader genre of general conceptual beliefs, whose main characteristics are weak methodology and logical structure, strong affective and dispositional constraints, epistemic closure and mauvaise foi, and whose main function is practical and self-representative (not epistemic). The (...) paper also claims that political theory and social sciences had some influence in legitimizing certain ideas and stereotypes that are exacerbated in conspiracy beliefs, while other te(le)ological conceptions, such as finalism and providence, may be an important source of ideas that turn out to be widely spread in contemporary criticism towards those same beliefs. (shrink)

How do people think about the mental states of robots? Experimental philosophers have developed various models aiming to specify the factors that drive people's attributions of mental states to robots. Here we report on a new experiment involving robots, the results of which tell against competing models. We advocate a view on which attributions of mental states to robots are driven by the same dual-process architecture that subserves attributions of mental states more generally. In support of this view, we leverage (...) recent psychological research on human-robot interaction that involve ecologically-valid stimuli such as Roombas and humanoid robots. (shrink)

In this paper I deal with Nietzsche's theory of knowledge in the context of 19th century epistemology. In particular, I argue that, even though Nietzsche shows the ontological lack of content of truths (both on the theoretic and on the moral plane), he nevertheless leaves the space for a practical use of them, in a way that can be compared with William James' pragmatism. I thus deal with Nietzsche's and James' concept of "truth", and show their relationship with some outcomes (...) of Ernst Mach's epistemology. (shrink)

During the second decade of the 20th century Hans Kleinpeter, an Austrian scholar devoted to the development of the modern science, published some brief papers on Nietzsche’s thought. Kleinpeter has been one of the main upholders of Mach’s epistemology and probably the first who connected his ideas with the philosophy of Nietzsche. In his book on Der Phänomenalismus (1913) he described a new world view that arose in the 19th century, a perspective that ‒ according to him ‒ completely contrasted (...) the mechanistic and metaphysical world view of the old school of scientific inquiry. The main outcome of the scientists whose name was related with this perspective (e.g. Clifford, Maxwell, Kirchoff and, obviously, Mach himself) has been the refusal of the absolute value of any “truth”. Kleinpeter’s statements on this topic are a good example of the rising of a Scientific Philosophy, whose development involved many scientists and thinkers that later set up the Verein Ernst Mach and the Wiener Kreis. On the other hand, his interest on Nietzsche is a relevant case of reception of the latter’s thought, that Kleinpeter puts into the context of the contemporary epistemology. In fact, he considers Nietzsche as one of the main upholders of the phenomenalistic world view, and states that he «took part at the same renewal of philosophical investigation that arose from the latest results of scientific inquiry» during the 19th century. A renewal whose main outcomes has been presented by John Stallo in his book on The Concepts and Theories of Modern Physics (1881), which Kleinpeter translated in German and published in 1901. According to Kleinpeter, in Nietzsche’s writings (mostly unpublished) one can find a theory of knowledge quite close to the one presented by both Mach and the new born Pragmatism, i.e. the complete refusal of an absolute truth and, therefore, the development of an antimetaphysical world view. In my paper I’ll discuss the main statements presented by Kleinpeter on this topic and show which of Nietzsche’s ideas has actually been in compliance with the main outcomes of late 19th century science. Thus, I’ll carry out a reconstruction of an unfamiliar side of the first period of reception of the philosophy of Nietzsche and its relevance to the development of a new (scientific) world view. (shrink)

This paper studies the relationship between promoting people's welfare and respecting their autonomy of choice under risk. I highlight a conflict between these two aims. Given compelling assumptions, welfarists end up disregarding people's unanimous preference, even when everyone involved is entirely rational and only concerned with maximizing their own welfare. Non-welfarist theories of social choice are then considered. They are shown to face difficulties, too: either they fail to respect the value of welfare in at least one important sense, or (...) they end up prioritizing different people's welfare differently in non-risky choices, on the basis of their attitudes to risk, which are intuitively irrelevant in this context. (shrink)

During his late period, Nietzsche focused on the problem of the “value of truth”, since according to him it plays an important role on Western culture and its anthropology. That reflection had been influenced by some outcomes of the late-nineteenth century scientific research, and can be therefore compared with other strategies that, during those years, faced the relativism implied in modern epistemology, e.g. William James’s Pragmatism. This paper aims to explore the pragmatic feature of Nietzsche’s investigation on truth. As will (...) be shown, Nietzsche’s perspectival thought can indeed be compared with classic Pragmatism on several aspects, e.g. the cultural context out of which both these philosophical position arised, and the broad consequences of their impact on European culture. (shrink)

The essay focuses, firstly, on the notion of evil in William James’ Varieties of Religious Experience (VRE). James identified evil with a pathological mental fact, “depression”, and analyzed it according to different thresholds and degrees of symptomatic severity: from the more conscious, intellectualized and, apparently, superficial cases to the more painful and obscure, which, according to his view, were also the deepest ones. The second aim of this essay is to cast light on James’ theory of religious conversion. According to (...) James, once the believer has reached a new mental balance and experienced a lasting happiness thanks to his change of mind, evil comes again to him under the form of a persistent and warning memory of the past troubling experience, a memory that is functional to preserve his new belief-system. We define this memory and its role as “functional atheism” and propose to transpose this notion from the uncertain realm of inner experience, where James originally put it, to the narrative and neurocognitive grounds, where it may lead to more original and wider developments. (shrink)

Tra i numerosi autori attivi nel campo delle scienze naturali che Friedrich Nietzsche ebbe modo di conoscere nel corso della propria vita, Ernst Mach rappresenta certamente un caso significativo. La sua presenza all'interno degli scritti del filosofo è pressoché nulla, ma la comunanza dei temi trattati e la particolare affinità delle prospettive adottate in materia di teoria della conoscenza invitano ad avvicinare questi due autori e a ipotizzare un qualche tipo di influsso diretto tra loro. Ciononostante, fino ad oggi non (...) era mai stato svolto uno studio critico e completo che esaminasse e discutesse tale relazione. Muovendo dai contenuti di una delle principali opere di Mach, i "Beiträge zur Analyse der Empfindungen" (1886) questo volume delinea un quadro esegetico che fa di Mach non tanto un referente diretto, quanto piuttosto il segnale di una prospettiva di ricerca che in qualche modo stimolò l'interesse di Nietzsche e che per molti aspetti egli mostra di condividere. (shrink)

The chapter explores comparatively the attention to the practical dimension that—each in his own way—Michel Foucault, Friedrich Nietzsche, and the classic pragmatist thinker William James pay when confronted with the challenge of providing a non-skeptical response to the relativist stance on truth that arose in the post-Kantian age. Particular focus will be given to the extent to which these three authors conceived of the practical framework as the only one that allows us to meaningfully address and determine truth.

The fact that Internet companies may record our personal data and track our online behavior for commercial or political purpose has emphasized aspects related to online privacy. This has also led to the development of search engines that promise no tracking and privacy. Search engines also have a major role in spreading low-quality health information such as that of anti-vaccine websites. This study investigates the relationship between search engines’ approach to privacy and the scientific quality of the information they return. (...) We analyzed the first 30 webpages returned searching “vaccines autism” in English, Spanish, Italian, and French. The results show that not only “alternative” search engines but also other commercial engines often return more anti-vaccine pages (10–53%) than Google (0%). Some localized versions of Google, however, returned more anti-vaccine webpages (up to 10%) than Google. Health information returned by search engines has an impact on public health and, specifically, in the acceptance of vaccines. The issue of information quality when seeking information for making health-related decisions also impact the ethical aspect represented by the right to an informed consent. Our study suggests that designing a search engine that is privacy savvy and avoids issues with filter bubbles that can result from user-tracking is necessary but insufficient; instead, mechanisms should be developed to test search engines from the perspective of information quality (particularly for health-related webpages) before they can be deemed trustworthy providers of public health information. (shrink)

«Questo è il vero fenomenalismo e prospettivismo, come lo intendo io», scrive Nietzsche in FW 354, chiudendo una lunga riflessione sul tema della coscienza e del bisogno di comunicazione dell’uomo. Mantenendo sullo sfondo le questioni più strettamente legate alla dimensione psicologica, vorrei partire da questa dichiarazione per considerare alcuni aspetti della teoria della conoscenza di Nietzsche ed intervenire in una nuova determinazione del suo carattere prospettico. In particolare, vorrei soffermarmi sul tema del gregge umano e della specie come reale soggetto (...) della visione prospettica, per poi discutere il riferimento al fenomenalismo rintracciabile in alcuni appunti dedicati ad una declinazione del Wille zur Macht come conoscenza. (shrink)

Discursive pluralism, recently fostered by anti-representationalist views, by stating that not all assertions conform to a descriptive model of language, poses an interesting challenge to representationalism. Although in recent years alethic pluralism has become more and more popular as an interesting way out for this issue, the discussion also hosts other interesting minority approaches in the anti-representationalist camp. In particular, the late stage of contemporary expressivism offers a few relevant insights, going from Price's denunciation of “placement problems” to Brandom's inferentialism. (...) This paper attempts to show how these expressivist ideas combine well together, composing a unitary and metaphysically sober metaphilosophical framework. (shrink)

This chapter explores Nietzsche’s and Wittgenstein’s views on language and knowledge, establishing a philosophical dialogue between two different positions, which are based on a similar anti-essentialist and instrumentalist concern. The chapter will first focus on Nietzsche’s conception of language as the expression of valuational perspectives developing through the natural and cultural history of mankind. It will then consider Wittgenstein’s account of language as the inherited background of our practical engagement with the world. Finally, by bringing Nietzsche’s and Wittgenstein’s views together, (...) the last section reflects on the crucial strategic move they make in their respective battle against the bewitchment of our intelligence by means of language. -/- . (shrink)

(English:) This contribution attempts a first non-normative approach to the problem of the classic, its definition and its meaning in an age of globalization. It reviews a series of common representations of the classic (and other analogous or contrary terms), stressing the programmatic-ideological aspect that generally characterizes them. Classic, actually, tends to be a foundational category, and therefore rests on delimitations that determine its exclusiveness as opposed to something else. This paper, in particular, criticizes the last boundary of the exclusivity (...) of the classic, that is, its normative opposition to fashion and actuality. On the contrary, it is argued that there is a substantial link between classic, actuality and fashion. On the basis of this connection, two deflationary definitions of the classic are proposed: the first regards it as part of the broader process of construction of historical identity by concrete individuals. The second, on the other hand, conceives it as a product of art, and, therefore, of a formative process of abilities, skills, taste, by which the classic becomes the object of technical, aesthetic and teleological judgments. -/- (Spanish:) En esta contribución se intenta una primera aproximación no normativa al problema del clásico, su definición y su significado en una era de globalización. Se revisa una serie de representaciones comunes sobre lo clásico (y otros términos análogos o contrarios), se destaca el aspecto programático-ideológico que por lo general las caracteriza. Clásico, en efecto, tiende a ser una categoría fundacional, por lo cual se apoya en delimitaciones que determinan su exclusividad por oposición a otra cosa. En este trabajo, en particular, se critica la última frontera de la exclusividad de lo clásico, es decir, su oposición normativa a la moda y la actualidad. Por el contrario, se argumenta que existe un vínculo sustancial entre el clásico, la actualidad y la moda. A partir de esta conexión, se proponen dos definiciones deflacionarias del clásico: la primera lo considera parte del proceso más amplio de construcción de la identidad histórica por parte de individuos concretos. El segundo, en cambio, lo concibe como un producto del arte, y, por tanto, de un proceso de formación de competencias, habilidades, gusto, por el cual el clásico se convierte en objeto de juicios técnicos, estéticos y teleológicos. (shrink)

The knowledge of truth, in Plato, is an experience that calls for conversion of the soul (μεταστροφή, περιστροφή). The basic feature of this experience consists in some sort of connection, which is constantly at work, between rational arguments and their non-rational conditions, briefly, lógos and páthos. How does this connection show up in Plato? Its crucial importance emerges many times at both narrative (récit) and theoretical level. In the three parts of my contribution, I show how logos-pathos intertwines with Plato's (...) notion of conversion considered as a double-sided phenomenon, as both "process" of moral education and "noetic event". (shrink)

During his late period, Nietzsche is particularly concerned with the value that mankind attributes to truth. In dealing with that topic, Nietzsche is not primarly interested in the metaphysical disputes on truth, but rather in the effects that the "will to truth" has on the human being. In fact, he argues that the "faith in a value as such of truth" influenced Western culture and started the anthropological degeneration of the human type that characterizes European morality. To call into question (...) the value of truth is therefore necessary, if one wants to help mankind to find her way in the labyrinth of nihilism. -/- In this new addition to Nietzsche scholarship, Gori explores the origin and aim of the philosopher's late perspectival thought by merging the theoretical with the historical approach, with a special focus on the epistemological debate that influenced Nietzsche. As a result, the book provides a contextual reading of the issue that supports the idea that Nietzsche’s attitude in addressing the problem of truth is, in a broad sense, pragmatic. (shrink)

The environment can elicit biological responses such as oxidative stress (OS) and inflammation as a consequence of chemical, physical, or psychological changes. As population studies are essential for establishing these environment-organism interactions, biomarkers of OS or inflammation are critical in formulating mechanistic hypotheses. By using examples of stress induced by various mechanisms, we focus on the biomarkers that have been used to assess OS and inflammation in these conditions. We discuss the difference between biomarkers that are the result of a (...) chemical reaction (such as lipid peroxides or oxidized proteins that are a result of the reaction of molecules with reactive oxygen species) and those that represent the biological response to stress, such as the transcription factor NRF2 or inflammation and inflammatory cytokines. The high-throughput and holistic approaches to biomarker discovery used extensively in large-scale molecular epidemiological exposome are also discussed in the context of human exposure to environmental stressors. We propose to consider the role of biomarkers as signs and to distinguish between signs that are just indicators of biological processes and proxies that one can interact with and modify the disease process. (shrink)

In the 1881 note 11 [156], Nietzsche mentions the “infinitely small moment” as “the highest reality and truth” for the individual who tries to contrast the “uniformity of sensations” and to affirm his “idiosyncratic taste”. The fragment explores some ideas on the herd instinct that will be developed in "The Gay Science"; observations on the cultural and anthropological value of science; critical refections on metaphysical realism. Most important, these considerations focus on the relationship between man and society, which is the (...) plane of the standardized “normal taste” selected throughout the evolution of mankind. The paper explores these issues and especially deals with the dialectic relationship between the individual and the community viewpoint that Nietzsche seems to take into account. (shrink)

The paper provides a thorough account of the relationship between Ernst Mach’s thought and that of an apparently more intellectually distant near-contemporary, Friedrich Nietzsche. The consistency of their views is in fact substantial, as I try to show within the paper. Despite their interests being different, both Mach and Nietzsche were concerned with the same issues about our intellectual relationship with the external world, dealing with the same questions and pursuing a common aim of eliminating worn-out philosophical conceptions. Moreover, it (...) can be argued that both Mach and Nietzsche converged on what we now know as the problem of realism versus anti-realism in the philosophy of science, and that they both rejected ‘representational’ (realist) conceptions of science in favour of a certain sort of pragmatic anti-realism, whose focus was on the role science plays as a means of orientation. (shrink)

In The Analysis of Mind (1921), Bertrand Russell stresses the importance of William James’ late neutral monist view of consciousness for the studies in psychology. In so doing, he focuses on a topic whose roots can be traced back to the nineteenth-century European debate on physiology and scientific psychology. In this introductory paper I shall briefly outline the path that, starting from the revival of Kant in the German scientific debate, leads to both Ernst Mach’s and William James’ questioning the (...) value of the I or consciousness as a substance concept. (shrink)

Aim of this paper is to reflect on the anthropological ideal Nietzsche outlines in his late period. The way Nietzsche deals with concepts such as “German”, “(good) European”, and “free spirit” in the sections of Twilight of the Idols which deal with Goethe will be especially considered. Furthermore, I shall argue that Renaissance plays an important role in Nietzsche’s anthropological project, for it helps to define the spiritual strength which characterizes the health type of man to which Nietzsche destined his (...) late philosophical wisdom and gay science. (shrink)

We discuss the role of perceptron (or threshold) connectives in the context of Description Logic, and in particular their possible use as a bridge between statistical learning of models from data and logical reasoning over knowledge bases. We prove that such connectives can be added to the language of most forms of Description Logic without increasing the complexity of the corresponding inference problem. We show, with a practical example over the Gene Ontology, how even simple instances of perceptron connectives are (...) expressive enough to represent learned, complex concepts derived from real use cases. This opens up the possibility to import concepts learnt from data into existing ontologies. (shrink)

Review of the book "Analytic Philosophy and the Later Wittgensteinian Tradition" by Paolo Tripodi.

ITA: Quello del “buon europeo” è in Nietzsche un tema significativo, che si presenta originariamente connesso alle riflessioni di Nietzsche sulla cultura europea, arricchendosi col tempo di una portata filosofica che si lega agli obiettivi del suo pensiero maturo. Scopo del presente articolo è di mostrare la genesi e l’evoluzione di tale concetto, a partire dalle sue prime occorrenze in Umano, troppo umano I fino al suo compiuto sviluppo negli scritti del 1885-87. Tale studio permetterà di evidenziare il particolare valore (...) che Nietzsche attribuisce ai “buoni europei”, in quanto promotori dello sviluppo spirituale conseguente alla compiuta liberazione della morale cristiana. ENG: The “good European” is a rich and important topic in Nietzsche. It is first related to Nietzsche’s early reflections on European culture, and during the 1880’s it gains philosophical value, being strictly connected with the purposes of Nietzsche’s mature thought. The aim of this paper is to track the genesis and development of the notion of “good European”, from Human, all too Human I to Nietzsche’s writings from the years 1885-1887. That investigation shall particularly show the meaning and value that Nietzsche attributes to the good Europeans; as for him, they are in fact the leaders of the spiritual development that follows the overcoming of Christian morality. (shrink)

Ideologies, worldviews, or simply personal theories, often acquire a distorted and pathological character, and become a factor of alienation rather than an epistemic resource and an aid for personal existence. This paper attempts to better define the limits and characteristics of this experience, which we call distorted intellectual beliefs, or general conceptual beliefs (GB), while trying to highlight both its sometimes dramatic background and its personal and social consequences, which are no less potentially deleterious. We believe that such experiences should (...) not be confused tout court with a broader and more complex phenomenon, such as extremism and politico-religious radicalism, but are a specific typology of that broader and multifaceted fact that is self-deception. We hypothesize that the self-deception implicit in experiences of intellectual distortion produces a cognitive dissonance of which the subject is normally, though with varying intensity, aware (or may become aware through honest introspection). The phenomenon occurs in two forms: one is normal (sporadic), the other is exceptional (systematic). The passage from one to the other is a complex process of escalation and de-escalation, on which multiple external and internal variables act. In its ascending path, it essentially coincides with a process of psychological polarization and cognitive "de-pluralization", while its descending phase marks a return to reality and a "re-pluralization", where the subject returns to being what he basically is, namely, an active and tireless meaning seeker. In the central part of the chapter, similarities and differences between processes of deradicalization and phenomena of religious deconversion are analyzed, with reference, among others, to the case of the Austro-Hungarian writer Arthur Koestler. -/- An abridged version of this text has been delivered for the Workshop "Explaining Extreme Belief and Extreme Behavior", September 15-16, 2022, Vrije Universiteit Amsterdam. I am grateful to David Konstan (NYU) for reading and commenting on a first version of this chapter and to Rik Peels (VUA) for his comments and questions during the Workshop. I would also like to thank my bachelor's and master's students at UDG, who discussed these topics at length with during semester 2022-B. (shrink)

Ernst Mach (1838-1916) è stato una figura di riferimento per la cultura scientifica e filosofica tardo-ottocentesca e dei primi decenni del Novecento. Le sue ricerche in fisica e psicologia, così come il lavoro epistemologico che emerge dalle pagine di opere quali La meccanica nel suo sviluppo storico-critico e Conoscenza ed errore, hanno influito notevolmente su molti autori a lui contemporanei. In questi testi, Mach delinea una concezione antimetafisica del pensiero scientifico e una concezione biologico-evolutiva della conoscenza umana che si ritrovano (...) elaborate in vario modo nella teoria della relatività di A. Einstein, nell’epistemologia evoluzionistica di K. Popper e D. Campbell, nel pragmatismo di W. James e, più in generale, nelle idee che animarono il primo Circolo di Vienna. I saggi raccolti nel presente volume si propongono di commemorarne la figura e l’opera, guardando a Mach come figura di confine tra prospettive di indagine che la storia della filosofia dell’ultimo secolo ha spesso visto contrapposte. (shrink)

This paper is a detailed and critical report of the debate between Rorty and Habermas (published in R.Brandom(ed.),"Rorty and His Critics", Blackwell, Oxford 2000) about the importance of truth and epistemic justification in communicative practices. They here present two different versions of the idea of communicative reason. I try to compare them and to evaluate their vices and virtues.

Friedrich Nietzsche’s criticism towards the substance-concept „I“ plays an important role in his late thought, and can be properly understood by making reference to the 19th century debate on the scientific psychology. Friedrich Lange and Ernst Mach gave an important contribution to that debate. Both of them developed the ideas of Gustav Fechner, and thought about a „psychology without soul“, i.e. an investigation that gives up with the old metaphysics of substance in dealing with the mind-body problem. In this paper (...) I shall deal with both Lange and Mach (whose writings has been read by Nietzsche), in order to shed some light on Nietzsche’s rejection of the „I“ in philosophy. (shrink)

In this paper I discuss the role played by Ernst Mach on Nietzsche’s thought. Starting from the contents of his Beiträge zur Analyse der Empfindungen, I’ll show the close similarities between their view on both human knowledge and the scientific world description. In his writing on science Nietzsche shares Mach’s critique to the 19th century mechanism and its metaphysical ground, as much as his way of defining the substantial notions such as matter, ego and free will. Moreover, my investigation will (...) make it clear that Mach cannot be seen as a direct source of Nietzsche’s thought, since the latter wrote many times on the same subjects long before his first reading one of his works. Rather, it is possible to consider the writings of Lange, Spir and Spencer as the first sources of Nietzsche’s views on the main themes Mach dealt with in his work from 1886. (shrink)

Hilary Putnam spent much of his career criticizing the fact/value dichotomy, and this became apparent already during the phase when he defended internal realism. He later changed his epistemological and metaphysical view by endorsing natural realism, with the consequence of embracing alethic pluralism, the idea that truth works differently in various discourse domains. Despite these changes of mind in epistemology and in theory of truth, Putnam went on criticizing the fact/value dichotomy. However, alethic pluralism entails drawing distinctions among discourse domains, (...) especially between factual and nonfactual domains, and these distinctions are in tension with the rejection of the fact/value dichotomy, as this would in principle hinder factual domains as genuine. This issue raises, prima facie, some doubts about the effective compatibility of these views. (shrink)

Biomarkers are widely used not only as prognostic or diagnostic indicators, or as surrogate markers of disease in clinical trials, but also to formulate theories of pathogenesis. We identify two problems in the use of biomarkers in mechanistic studies. The first problem arises in the case of multifactorial diseases, where different combinations of multiple causes result in patient heterogeneity. The second problem arises when a pathogenic mediator is difficult to measure. This is the case of the oxidative stress (OS) theory (...) of disease, where the causal components are reactive oxygen species (ROS) that have very short half-lives. In this case, it is usual to measure the traces left by the reaction of ROS with biological molecules, rather than the ROS themselves. Borrowing from the philosophical theories of signs, we look at the different facets of biomarkers and discuss their different value and meaning in multifactorial diseases and system medicine to inform their use in patient stratification in personalized medicine. (shrink)

Ineffability in Plato is a conundrum. There are at least four dimensions of ineffability in Platonic texts: epistemic (divine), strategic (religious), unspeakability and incommunicability. In this paper, I deal only with the first dimension, which is strictly epistemic in kind, and defend that Plato rejects divine ineffability, namely, the belief that the knowledge of the divine in general is inaccessible to the human mind. Several crucial passages attest to this rejection unequivocally. They show that Plato attached a great philosophical relevance (...) to what I call the equivalenceprinciple, namely, the interdependence or specularity between human and divine intelligence. The assertion of this principle represents the Platonic path to absolute knowledge, which I try to locate in the broader context of the history of philosophy, from early philosophers to Hegel. (shrink)

The paper explores Nietzsche's observations on language in Human, All Too Human I, 11; reflects on the anti-realist position that Nietzsche defends in that aphorism; and focuses on the role she plays in his later investigation on Western culture and its anthropology. As will be argued, Nietzsche's criticism towards common sense realism is consistent with some pragmatist epistemologies developed during the late-nineteenth and early-twentieth century. This treat of " timeliness " does not limit Nietzsche's originality on the topic. In fact, (...) the idea that philosophy can contrast the metaphysical commitment of common sense can be seen as the theoretical tool that allows Nietzsche to operate on the development of European culture and society. (shrink)

The paper suggests a distinction between two dimensions of grasp of concepts within an inferentialist approach to conceptual content: a common sense "minimum" version, where a simple speaker needs just a few inferences to grasp a concept C, and an expert version, where the specialist is able to master a wide range of inferential transitions involving C. This paper tries to defend this distinction and to explore some of its basic implications.

Wittgenstein’s Investigations proposed an egalitarian view about language games, emphasizing their plurality (“language has no downtown”). Uses of words depend on the game one is playing, and may change when playing another. Furthermore, there is no privileged game dictating the rules for the others: games are as many as purposes. This view is pluralist and egalitarian, but it says little about the connection between meaning and use, and about how a set of rules is responsible for them in practice. Brandom’s (...) Making It Explicit attempted a straightforward answer to these questions, by developing Wittgensteinian insights: the primacy of social practice over meanings; the idea that meaning is use; the idea of rule–following to understand participation in social practices. Nonetheless, Brandom defended a non–Wittgensteinian conception of discursive practice: language has a “downtown”, the game of “giving and asking for reasons”. This is the idea of a normative structure of language, consisting of advancing claims and drawing inferences. By means of assertions, speakers undertake “commitments” that can be challenged/defended in terms of reasons (those successfully justified can gain “entitlement”). This game is not one among many: it is indispensable to the very idea of discursive practice. In this paper, my aim will be that of exploring the main motivations and implications of both perspectives. (shrink)

The aim of this paper is to shed light on Nietzsche’s late investigation of the Western human being, with particular reference to Twilight of the Idols. I shall argue that this investigation can be seen as a “pragmatic anthropology,” according to the meaning that Kant gave to this notion in 1798. Although the paper focuses on Nietzsche’s thought, an analysis of Kant’s anthropology and the comparison between and Nietzsche’s late views of the human being, will show both their differences and (...) similarities on the topic. (shrink)

Platonic religiosity is the first of two volumes devoted to the analysis of religiosity or religious feeling (pathos) in Plato. -/- (Back cover) Platonic Religiosity is a hermeneutical attempt to read Platonic works from the perspective of their religiosity. The aspects examined in the book are limited for the moment to the most basic, perhaps even the simplest, dimensions of religious feeling, those involving the representation of a relationship between man and divinity, Earth and Heaven, "low" and "high". Low and (...) high are spatial metaphors constitutive of our thinking. Although, in this case, they indicate the link between man and the super-sensible world, they also presuppose, at all times, the devout feeling (and the risk) of an insurmountable distance and remoteness that divides men from the numen. The need to affirm the relationship partly overcomes the presence of this feeling of distance, but never manages to neutralise it completely. -/- Religious feeling as such always oscillates between two terms: the need to establish a relationship with the divinity, and thus to guarantee its proximity to man, and the affirmation of its transcendence, namely the distance that divides us from the numen, up to the point, eventually, where the danger becomes the greatest: the denial of the god by man (atheism) or the human feeling of being abandoned by the god. The presence of these oscillations in the Platonic texts is analysed in several chapters of the book, devoted to different themes, such as the representations of reciprocity (do ut des), the images of the friendly god and the hostile god, the feeling of the threshold, prayers and invocations, verecundia and nostalgia, the feeling of dependence, the notion of prescience, assimilation to the god, the different types of ineffability, the role of atheism and incredulity, and lastly the notion of conversion, which substantiates Platonic religiosity by characterising it in the sense of a redemption-belief. (shrink)

The paper aims to investigate some aspects of Ernst Mach’s epistemology in the light of the problem of human orientation in relation to the world (Weltorientierung), which is a main topic of Western philosophy since Kant. As will be argued, Mach has been concerned with that problem, insofar as he developed an original pragmatist epistemology. In order to support my argument, I firstly investigate whether Mach defended a nominalist or a realist account of knowledge and compare his view to those (...) elaborated by other pragmatist thinkers, such as W. James, H. Vaihinger and H. Poincaré. Secondly, the question of what does it mean, for Mach, to orient ourselves in science is addressed. Finally, it will be argued that, although Mach tried to keep his epistemology restricted to a mere operational and economical account of science, that question involves the wider plane of practical philosophy. (shrink)

Hans Kleinpeter’s letters to Ernst Mach held in the Deutsches Museum Archive in Munich are of the greatest importance in order to learn some details of the relationship between these scholars. In the three letters here entirely published for the first time, Kleinpeter shows his interest for Nietzsche’s thought, and states that some of the latter’s ideas are in compliance with Mach’s epistemology.

The paper defends the idea that Jamesian pragmatism, Nietzschean perspectivism, and philosophical anthropology represent a consistent triad, for the similarities and connections between the first two positions rest in their engagement with the anthropological question. As will be argued, a) pragmatism is concerned with anthropology and that it deals with a fundamental issue of Nietzsche’s late thought; b) the problem of the type of man (der Typus Mensch) is involved in Nietzsche’s questioning the value of truth, and perspectivism is an (...) alternative view to Platonic and Christian metaphysics which arises from the same phenomenalist conception of knowledge defended by James ; c) Nietzsche’s interest in developing a philosophy that affirms the perspectival character of existence is primarily anthropological, and this is in fact the pragmatic criterion of validity that one can attribute to Nietzschean perspectivism. (shrink)

This paper is devoted to a comparison between Ernst Mach's and Friedrich Nietzsche's anti-metaphysical approach to scientific and philosophical concepts. By making reference to Mach’s early essay on the conservation of energy (Die Geschichte und die Wurzel des Satzes von der Erhaltung der Arbeit, 1872), I argue that Nietzsche shares with him the idea that the concepts we adopt are only useful fictions developed during the history of humankind and its culture. This idea is fundamental for the development of modern (...) science, since Mach’s epistemology contributed to give up the mechanistic (Newtonian) view of physics. (shrink)

In Part One of Beyond Good and Evil Nietzsche writes that anyone who believes in “immediate certainties” such as “I think” encounters a series of “metaphysical questions”. The most important of these “problems of intellectual knowledge” concerns the existence of an ‘I’, as much as our believing it to be the cause of thinking. Therefore, any remark about our mental faculties directly follows from our defining what we could call the basic psychical unity, i.e. our view on higher-level psychical functions (...) is strictly related with the properties we attribute to the notion of ‘I’. As we know, the main ideas on this subject that Nietzsche states in his book from 1886 come from the neo-kantian views of Lange, Spir and Teichmüller, and we cannot forget the important (even if hidden) reference to Lichtenberg in § 17 of the same work. Nevertheless, Nietzsche seems to move beyond all these sources, and in many of his writings we can find a new definition of the ‘ego’, finally free from any reference to a thing in itself, and for this reason closer to the ideas of the Austrian scientist Ernst Mach. In this paper I shall carry these remarks out. I’ll show the main properties of the notion of ‘I’ Nietzsche concerns with in his writings and, therefore, the grounds of his view on the mind-body problem. Moreover, I will argue that, once we observe that Nietzsche looks at the ‘ego’ as a mere regulative fiction having no ontological value out of the chain of sensation and representation it brings together, we could find out the close similarity with the way Mach defines it in his Beiträge zur Analyse der Empfindungen (1886). This reference could help us to understand in a better way some statements Nietzsche wrote in his notebooks, and, secondly, to show how strictly was his philosophy of mind related with the main outcomes of 19th century science. Indeed, Nietzsche’s refusal of the belief “that there must necessarily be something that thinks” ‒ a view that results from the anti-metaphysical intent leading his naturalism ‒ seems to be one of the most important assumptions of the new born physiological psychology, an idea out of which many of the 20th century philosophical debates arose. (shrink)

Friedrich Nietzsche's criticism towards the substance-concept «I» plays an important role in his late thought, and can be properly understood by making reference to the 19th century debate on the scientific psychology. Friedrich Lange and Ernst Mach gave an important contribution to that debate. Both of them developed the ideas of Gustav Fechner, and thought about a «psychology without a soul», i.e. an investigation that gives up with the old metaphysics of substance in dealing with the mind-body problem. In this (...) paper I shall deal with Lange's and Mach's view of the I/soul, in order to shed some light on Nietzsche's rejection of the «I» in philosophy. (shrink)

La realtà del passato rappresenta uno dei principali problemi riguardanti la semantica giustificazionista proposta da Michael Dummett. L’antirealismo tipico di questa prospettiva determina una concezione del passato piuttosto controintuitiva secondo cui esso «cessa di esistere» quando non lascia tracce e testimonianze. In Truth and the Past, Dummett è tornato sulla questione abbandonando l’antirealismo sul passato con l’obiettivo di evitare questa concezione. Questa svolta rappresenta un inedito spostamento in direzione del realismo, limitato tuttavia dal netto rifiuto di aderire ad una nozione (...) di verità bivalente. Il mio intervento intende ricostruire e analizzare criticamente le ragioni di questa svolta di Dummett e cercare di sondare la solidità e la coerenza di questa rimodulazione del giustificazionismo. (shrink)

Il pensiero prospettivistico del Nietzsche maturo sorge come reazione alla «fede in un valore metafisico e in sé della verità» che, a partire da Platone, ha animato la cultura occidentale. Agli occhi di Nietzsche, tale fede si trova all’origine del processo di degenerazione antropologica che ha caratterizzato la morale europea, ed è pertanto su di essa che occorre operare criticamente se si vuole avviare un contromovimento in grado di permettere all’umanità di orientarsi nei meandri labirintici del nichilismo. Attraverso una contestualizzazione (...) delle riflessioni di Nietzsche sul tema del prospettivismo, il presente studio si propone di rilevare la componente pragmatista che si trova alla base di tale critica. In linea con quanto osservato da William James e condividendo molte delle istanze che il suo pragmatismo portò a maturazione, il pensiero prospettivistico di Nietzsche si presenta infatti come strategia per gestire lo svuotamento di senso della nozione di verità a cui conducono i risultati della moderna epistemologia. Esso consiste, in particolare, in una metodologia di orientamento che assume produttivamente su di sé gli spazi lasciati aperti da un sapere non più metafisico e dogmatico e che, pertanto, permette di avviare un nuovo percorso educativo per l’umanità a venire. (shrink)

Robert Brandom has developed an account of conceptual content as instituted by social practices. Such practices are understood as being implicitly normative. Brandom proposed the idea of implicit norms in order to meet some requirements imposed by Wittgenstein’s remarks on rule-following: escaping the regress of rules on the one hand, and avoiding mere regular behavior on the other. Anandi Hattiangadi has criticized this account as failing to meet such requirements. In what follows, I try to show how the correct understanding (...) of sanctions and the expressivist reading of the issue can meet these challenges. (shrink)

Among the many features that go hand in hand with the recent onset of populism in many countries, an interesting phenomenon is surely the shift of public discourse in the direction of social media. Is there any-thing special about communication in social media that is particularly suitable for the development of such movements and ideas? In what fol-lows, I provide an attempt to read Facebook comments as showing an anaphoric structure. This analysis permits me to give emphasis on a number (...) of interesting features that such communications exhibit. Final-ly, I try also to highlight some of the main implications of this model in comparison with ordinary communication. (shrink)

In this broad interview Robert Brandom talks about many themes concerning his work and about his career and education. Brandom reconstructs the main debts that he owes to colleagues and teachers, especially Wilfrid Sellars, Richard Rorty, and David Lewis, and talks about the projects he’s currently working on. He also talks about contemporary and classical pragmatism, and of the importance of classical thinkers like Kant and Hegel for contemporary debates. Other themes go deeper into the principal topics of his theoretical (...) work – in particular, his later understanding of expressivism, his take on the debate between representationalists and anti-representationalists in semantics, the main open problems for his wide inferentialist project, and his methodological preference for the normative vocabulary in his account of discursive practice. Finally, Brandom touches on the epistemic role of perception and on his views about the importance of the phenomenological aspects of perceptual experience. (shrink)