The paper examines the account of the mortal parts of the human soul in theTimaeus. What is their nature? What is their relationship to the immortal part of the soul and its inner structure on the one hand, and to the body and its organs and their functioning on the other? Are they incorporeal or corporeal? What kind of movement do they have? In what sense precisely are they ‘another kind of soul’ ?

It is often argued, most recently by Samuel Scheffler, that we should reconcile with our mortality as constitutive of our existence: as essential to its temporal structure, to the nature of deliberation, and to our basic motivations and values. Against this reconciliatory strategy, I argue that there is a kind of immortal existence that is coherently conceivable and potentially desirable. First, I argue against the claim that our existence has a temporal structure with a trajectory that necessarily culminates in (...) an ending. This claim is based on two false assumptions: that a life as a whole calls for narrative structure, and that narratives necessarily require closure as temporal endings. Second, I reject the proposal that temporal finitude is constitutive of the basic elements of diachronic agency, including the nature of deliberation and of our values. I argue that only finitude as scarcity of opportunities is constitutive of these elements. Additionally, scarcity might be present in an endless existence. Therefore, it is not incoherent to conceive of a recognizable and potentially desirable immortality that grounds the core features of diachronic agency. Thus, against the reconciliatory strategy, I conclude that we might never fully reconcile with mortality. Although we might embrace our inescapable mortality as essential to a fuller range of features of our existence, we can still justifiably regret our missing on an immortal existence. (shrink)

The question of origins continues to captivate human thought and sentiment, despite the postmodern insistence that knowledge of origins is impossible since it must lie beyond the boundaries of the origin of knowledge. Knowledge cannot seek causes that precede its own existence, it is said. Still, theoretical narratives continue to arise accounting for such things as the origin of the universe, of our star and solar system, of Earth, of life on the planet, of the human species, of self-aware human (...) cultures, and so on down into the origins of the local and particular. This should not be surprising; we sense that knowing our origins will tell us who we are. With this in mind, this particular originary analysis of the origin of language will critically compare some of the foundational tenets of generative anthropology with the objective findings of palaeoanthropology and linguistics. Furthermore, an originary proposal of my own will be tendered. (shrink)

In order to achieve the World Health Organization’s Millennium Development Goal of reducing maternal mortality by three quarters by 2015, a strong global commitment is needed to address this issue in low-income nations where the risk to women is greatest. A comprehensive international effort must include provision of obstetric and general medical care as well as community-based interventions, with an emphasis on the latter in nations where the majority of women deliver babies at home without a trained attendant. Methods: (...) This systematic analysis evaluates interventions published in Medline and CINAHL whose outcome measure is maternal mortality. Analysis includes components of the intervention, nation and maternal death rates. Results: Nine studies documented the effectiveness of various clinical and community-based interventions, including specific drug regimens and procedures, in reducing the risk of maternal death. Six studies reported interventions that did not significantly alter maternal mortality outcomes, and the intervention in one study demonstrated increased risk of maternal death. Conclusion: The dearth of evidence highlights the need for increased focus on translational research that bridges the gap between medical advances and community-based interventions that are feasible in low-income nations. This cannot be accomplished without a stronger commitment to reducing maternal mortality by global health practitioners and researchers. (shrink)

In his recent book, Death, Posthumous Harm, and Bioethics (Routeledge 2012), James Stacey Taylor challenges two ideas whose provenance may be traced all the way back to Aristotle. The first of these is the thought that death (typically) harms the one who dies (mortal harm thesis). The second is the idea that one can be harmed (and wronged) by events that occur after one’s death (posthumous harm thesis). Taylor devotes two-thirds of the book to arguing against both theses and the (...) remainder to working out the implications of their falsity for various bioethical concerns, including euthanasia, suicide, organ procurement, etc. In this brief article, I concentrate on Taylor’s case against the mortal harm thesis and suggest that his main argument against this claim begs the question. (shrink)

In this article I rethink death and mortality on the basis of birth and natality, drawing on the work of the Italian feminist philosopher Adriana Cavarero. She understands birth to be the corporeal event whereby a unique person emerges from the mother’s body into the common world. On this basis Cavarero reconceives death as consisting in bodily dissolution and re-integration into cosmic life. This impersonal conception of death coheres badly with her view that birth is never exclusively material but (...) always has ontological significance as the appearance of someone new and singular in the world of relations with others. This view of birth calls for a relational conception of death, which I develop in this article. On this conception, death is always collective, affecting all those with whom the one who dies has maintained relations: As such, our different deaths shade into one another. Moreover, because each person is unique in virtue of consisting of a unique web of relations with others, death always happens to persons as webs of relations. Death is relational in this way as a corporeal, and specifically biological, phenomenon, to which we are subject as bodily beings and as interdependent living organisms. I explore this with reference to Simone de Beauvoir’s memoir of her mother’s death from cancer. Finally I argue that, on this relational conception, death is something to be feared. (shrink)

This paper explores some connections between depictions of mortality in portrait-painting and philosophical (and psychoanalytic) treatments of our need to be recognized by others. I begin by examining the connection that Georg Simmel makes in his philosophical study of Rembrandt between that artist’s capacity for depicting his portrait subjects as non-repeatable individuals and his depicting them as mortal, or such as to die. After noting that none of Simmel’s explanations of the tragic character of Rembrandt’s portrait subjects seems fully (...) satisfactory, I then turn to Rousseau’s writing on our need for the recognition of others in order to argue that (1) it is at least as sources for the satisfaction of this need that other persons figure for us as irreplaceable (in a way that contrasts with the kinds of satisfaction that intersubstitutable things afford us); and that (2) it is exactly this kind of irreplaceability that Simmel is gesturing at in connecting the concepts of individuality and mortality in his writing on Rembrandt’s portraits. For the remainder of the paper I argue that the foregoing ideas are in fact central to the psychoanalytic writing of Melanie Klein, and in particular (a) Klein’s understanding the infant’s apprehension of other persons as internally related to their anxieties about the possibility of those persons’ irretrievable loss; (b) her understanding that it is as sources of recognition that others’ personhood is made salient to us; and (c) her treatment of portrait-painting as an activity for working through those aforementioned anxieties. (shrink)

Spanish translation of Jussi Backman, "Divine and Mortal Motivation: On the Movement of Life in Aristotle and Heidegger,” Continental Philosophy Review 38 (2005): 241–261. -/- Translated by Fernando Huesca Ramón, translation revised by Jean Orejarena Torres and César Mora Alonso.

The paper discusses Heidegger's early notion of the “movedness of life” (Lebensbewegtheit) and its intimate connection with Aristotle's concept of movement (kinēsis). Heidegger's aim in the period of Being and Time was to “overcome” the Greek ideal of being as ousia – constant and complete presence and availability – by showing that the background for all meaningful presence is Dasein, the ecstatically temporal context of human being. Life as the event of finitude is characterized by an essential lack and incompleteness, (...) and the living present therefore gains meaning only in relation to a horizon of un-presence and un-availability. Whereas the “theological” culmination of Aristotle's Nicomachean Ethics finds the supreme fulfillment of human life in the semi-divine self-immanence and self-sufficiency of the bios theōrētikos, a radical Heideggerian interpretation of kinēsis may permit us to find in Aristotle the fundamental structures of mortal living as self-transcendent movement. (shrink)

The paper gives (I) a short introduction to Aristotle’s theory of the soul in distinction to Plato’s and tries again (II) to answer the question of whether the individual or the general active mind of human beings is immortal by interpreting “When separated (χωρισθεìς)” (de An. III, 5, 430a22) as the decisive argument for the latter view. This strategy of limiting the question has the advantage of avoiding the probably undecidable question of whether this active νοῦς is human or divine. (...) The paper closes with an outlook (III) on the Christian belief in the resurrection of body and soul in a spiritual body (σῶμα πνευματικóν) (1 Corinthians: 15, 44) by accentuating the ethical aspect of the belief in individual immortality as a “need of reason” (Vernunftbedürfnis) (Kant, Critique of Practical Reason, A 256–258). (shrink)

What are the justifications for and constraints on the use of force in self-defense? In his book The Morality of Defensive Force, Jonathan Quong presents the moral status account to address this and other fundamental questions. According to the moral status account, moral liability to defensive harm is triggered by treating others with less respect than they are due. At the same time, Quong rejects the relevance of culpability to the morality of defensive harming. In this article I argue that (...) this rejection of culpability is unfounded and that Quong fails to establish his account as superior to the culpability account of liability to defensive harm. (shrink)

Narrative views of agency and identity arise in opposition to reductionism in both domains. While reductionists understand both identity and agency in terms of their components, narrativists respond that life and action are both constituted by narratives, and since the components of a narrative gain their meaning from the whole, life and action not only incorporate their constituent parts but also shape them. I first lay out the difficulties with treating narrative as constitutive of metaphysical identity and turn to its (...) function in practical identity. I then explore the ways narrative shapes our agency—by tapping into our motivational structures, providing an understanding of the social background within which our agency operates, guiding our agency through an understanding of our histories and aspirations, providing the links that structure actions internally, and allowing us to change the meaning of our pasts. I suggest that putting these functions of narrative together may allow us to genuinely shape our past motivational structures through our actions. Finally, if life has the form of a narrative, it may seem as if mortality is necessary for our lives and their contents to be meaningful: a narrative, it might seem, relies on the ending for its meaning. If so, an immortal life would be meaningless. I examine the possibility that even an immortal life may draw meaning from local narratives that constitute projects within such a life, while arguing that, to the contrary, narrative may be a tool exclusively adapted to mortal lives. (shrink)

Coral reefs provide substantial benefits to humans by generating biologically diverse ecosystems and reducing coastal hazards. However, in recent years, mass mortality of coral reefs due to bleaching has been witnessed in the ocean worldwide. Bleaching induced by the loss of the symbiotic relationship between algae and coral is mainly attributed to climate change. Marine protected areas (MPAs) can effectively prevent local disturbances but are less likely to conserve the coral reefs from global events like climate change. Other conservation (...) and restoration methods can be useful to protect and replenish the coral population temporarily, but whether they are feasible as sustainable conservation strategies is still equivocal. Coral reef mass mortality is not an exceptional occurrence but is linked to various instances of ecological loss, serving as an S.O.S. signal of severe prolonged climate extremes. (shrink)

Computational functionalism posits that consciousness is a computation. Here we show, perhaps surprisingly, that it cannot be a Turing computation. Rather, computational functionalism implies that consciousness is a novel type of computation that has recently been proposed by Geoffrey Hinton, called mortal computation.

If a problem is the collision between a system and a fact, Spinozism and German idealism’s greatest problem is the corpse. Life’s end is problematic for the denial of death’s qualitative difference from life and the affirmation of nature’s infinite purposiveness. In particular, German idealism exemplifies immortalism – the view that life is the unconditioned condition of all experience, including death. If idealism cannot explain the corpse, death is not grounded on life, which invites mortalism – the view that death (...) is the unconditioned condition of experience. In “Philosophical Letters,” Schelling critiques idealism, arguing that death symbolizes the regulative ideal of a philosophical system’s derivation, our striving for which unifies our rational activity. I interpret Schelling’s critique as explaining how death puts philosophy into question, an idea he develops in the Freedom essay and Berlin lectures. Death is not a problem to be solved by a system, but represents philosophy’s highest yet unrealizable end. (shrink)

“If the concept of God has any validity or any use,” James Baldwin writes in The Fire Next Time, “it can only be to make us larger, freer, and more loving. If God cannot do this, then it is time we got rid of Him.” This essay is a meditation on Baldwin’s claim. I begin by presenting Baldwin’s account of a grave danger that characterizes our social lives – a source of profound estrangement from ourselves and from one another. I (...) draw on the work of the theologian Howard Thurman in order to explain how faith in a loving God can enable us to cope with this danger in a manner that may render us, in some sense, larger, freer, and more loving. Finally, I sketch Baldwin’s account of how we might cope with this danger not by relying on God’s love, but rather by relying in certain ways on our love for one another. (shrink)

Personal time, as opposed to external time, has a certain role to play in the correct account of death and immortality. But saying exactly what that role is, and what role remains for external time, is not straightforward. I formulate and defend accounts of death and immortality that specify these roles precisely.

Bernard Williams’ discussion of immortality in “The Makropulos Case: Reflections on the Tedium of Immortality” has spawned an entire philosophical literature. This literature tends to focus on one of Williams’ central claims: if we were to relinquish our mortality, we would necessarily become alienated from our existence and environment—“bored,” in his terms. Many theorists have defended this claim; many others have challenged it. Even if this claim is false, though, it still isn’t obvious that we should choose to relinquish (...) our mortality, given the option. And this is puzzling. Death is generally regarded as an evil, meriting anxiety, dread, and avoidance. What is it about our mortality that makes us hesitant to relinquish it? In this paper, I aim to explain this hesitancy and to argue in its favor: we should be hesitant to relinquish our mortality. Further, I take my discussion to suggest that most of us probably shouldn’t take this option if we were given it. To make these points, I draw on Williams’ discussion of immortality, developing and extending his thought in order to better understand how mortality shapes the way we relate to our lives, particularly the commitments and values that make them meaningful. Our mortality, it seems, plays a crucial role in our lives standing for something. Relinquishing it thus means risking the loss of this value. (shrink)

Organismal death is foundational to the evolution of life, and many biological concepts such as natural selection and life history strategy are so fashioned only because individuals are mortal. Organisms, irrespective of their organization, are composed of basic functional units—cells—and it is our understanding of cell death that lies at the heart of most general explanatory frameworks for organismal mortality. Cell death can be exogenous, arising from transmissible diseases, predation, or other misfortunes, but there are also endogenous forms of (...) death that are sometimes the result of adaptive evolution. These endogenous forms of death—often labeled programmed cell death, PCD—originated in the earliest cells and are maintained across the tree of life. Here, we consider two problematic issues related to PCD (and cell mortality generally). First, we trace the original discoveries of cell death from the nineteenth century and place current conceptions of PCD in their historical context. Revisions of our understanding of PCD demand a reassessment of its origin. Our second aim is thus to structure the proposed origin explanations of PCD into coherent arguments. In our analysis we argue for the evolutionary concept of PCD and the viral defense-immunity hypothesis for the origin of PCD. We suggest that this framework offers a plausible account of PCD early in the history of life, and also provides an epistemic basis for the future development of a general evolutionary account of mortality. (shrink)

The ongoing COVID-19 pandemic has brought science to the fore of public discourse and, considering the complexity of the issues involved, with it also the challenge of effective and informative science communication. This is a particularly contentious topic, in that it is both highly emotional in and of itself; sits at the nexus of the decision-making process regarding the handling of the pandemic, which has effected lockdowns, social behaviour measures, business closures, and others; and concerns the recording and reporting of (...) disease mortality. To clarify a point that has caused much controversy and anger in the public debate, the first part of the present article discusses the very fundamentals underlying the issue of causative attribution with regards to mortality, lays out the foundations of the statistical means of mortality estimation, and concretizes these by analysing the recording and reporting practices adopted in England and their widespread misrepresentations. The second part of the article is empirical in nature. I present data and an analysis of how COVID-19 mortality has been reported in the mainstream media in the UK and the USA, including a comparative analysis both across the two countries as well as across different media outlets. The findings clearly demonstrate a uniform and worrying lack of understanding of the relevant technical subject matter by the media in both countries. Of particular interest is the finding that with a remarkable regularity (????>0.998), the greater the number of articles a media outlet has published on COVID-19 mortality, the greater the proportion of its articles misrepresented the disease mortality figures. (shrink)

The COVID-19 pandemic has made it especially visible that mortality data are a key component of epidemiological models, being a single indicator that provides information about various health aspects, such as disease prevalence and effectiveness of interventions, and thus enabling predictions on many fronts. In this paper we illustrate the interrelation between facts and values in death statistics, by analyzing the rules for death certification issued by the World Health Organization. We show how the notion of the underlying cause (...) of death can change in view of public health goals. This brings us to a general point about how non-epistemic factors, such as values and goals, are reflected in the choice of different measures in epidemiological models. We finally argue that this analysis is not only relevant from a theoretical point of view but also has important practical consequences. (shrink)

Background Previous analyses of democracy and population health have focused on broad measures, such as life expectancy at birth and child and infant mortality, and have shown some contradictory results. We used a panel of data spanning 170 countries to assess the association between democracy and cause-specific mortality and explore the pathways connecting democratic rule to health gains. -/- Methods We extracted cause-specific mortality and HIV-free life expectancy estimates from the Global Burden of Diseases, Injuries, and Risk (...) Factors Study 2016 and information on regime type from the Varieties of Democracy project. These data cover 170 countries and 46 years. From the Financing Global Health database, we extracted gross domestic product (GDP) per capita, also covering 46 years, and Development Assistance for Health estimates starting from 1990 and domestic health spending estimates starting from 1995. We used a diverse set of empirical methods—synthetic control, within-country variance decomposition, structural equation models, and fixed-effects regression—which together provide a robust analysis of the association between democratisation and population health. -/- Findings HIV-free life expectancy at age 15 years improved significantly during the study period (1970–2015) in countries after they transitioned to democracy, on average by 3% after 10 years. Democratic experience explains 22·27% of the variance in mortality within a country from cardiovascular diseases, 16·53% for tuberculosis, and 17·78% for transport injuries, and a smaller percentage for other diseases included in the study. For cardiovascular diseases, transport injuries, cancers, cirrhosis, and other non-communicable diseases, democratic experience explains more of the variation in mortality than GDP. Over the past 20 years, the average country's increase in democratic experience had direct and indirect effects on reducing mortality from cardiovascular disease (−9·64%, 95% CI −6·38 to −12·90), other non-communicable diseases (−9·14%, −4·26 to −14·02), and tuberculosis (−8·93%, −2·08 to −15·77). Increases in a country's democratic experience were not correlated with GDP per capita between 1995 and 2015 (ρ=–0·1036; p=0·1826), but were correlated with declines in mortality from cardiovascular disease (ρ=–0·3873; p<0·0001) and increases in government health spending (ρ=0·4002; p<0·0001). Removal of free and fair elections from the democratic experience variable resulted in loss of association with age-standardised mortality from non-communicable diseases and injuries. -/- Interpretation When enforced by free and fair elections, democracies are more likely than autocracies to lead to health gains for causes of mortality (eg, cardiovascular diseases and transport injuries) that have not been heavily targeted by foreign aid and require health-care delivery infrastructure. International health agencies and donors might increasingly need to consider the implications of regime type in their efforts to maximise health gains, particularly in the context of ageing populations and the growing burden of non-communicable diseases. (shrink)

The paper unfolds the problem of time focusing primarily on the dimension of the future, while, in the background of its sui generis questionings, it is based by a continuous, and again questioning, dialogue with Aristotle and Martin Heidegger. It is the existence of the future which is foremost analyzed, unravelled, dismantled, and 1 thought over in the course of this research. First, as Will-Being, then as Hold-Being. As a being, that is, which – in a particular view of the (...) future – we, humans, Holding on to ourselves, will and must Hold always, and which, with time, Holds on to us at the same time. Therefore the being of future must be grasped first as a being which … Is Not Yet. Consequently the following meditations ask and think over the question: what kind of existence is this Not-Yet-Being after all? And then: what is the actual, living, richly meaningful ontological, existential, and historical horizon of this question? It is here that the problem of human history, human death, and human freedom unfolds from, with a view to the horizon of its possible meanings and outlined possibilities of meanings. (shrink)

Book Review of Kevin Aho's One Beat More: Existentialism and the Gift of Mortality (Polity, 2022).

In this critical review of current diagnostic and treatment modalities regarding acute ST-segment elevation myocardial infarction (STEMI) in women and females, several strategies that can be utilized to decrease the time from symptom onset to diagnosis and definitive treatment will be introduced. The primary focus of this monograph is to present a systematic methodology for the diagnosis of STEMI in the presence of atypical symptoms of acute coronary syndrome (ACS). There are both social and biological factors impacting the current lack (...) of timely diagnosis and treatment in women and females who experience acute STEMI. As a result, it is the purpose of this paper to introduce three critical implementations for improving mortality and morbidity in women and females experiencing a STEMI. First, recognition of atypical ACS symptoms and timely acquisition of a 12-lead electrocardiograph (ECG) is crucial. Secondly, recognition of patterns indicating a STEMI or STEMI "equivalent" on the 12-lead ECG is required. Lastly, immediate treatment of the STEMI through percutaneous coronary intervention or fibrinolytic therapy, is pivotal in improving patient outcomes. (shrink)

The Guggenheim’s spring retrospective of the seminal Swedish painter, Hilma Af Klint, has, naturally, evoked a multitude of art critics and visual culture scholars who laud her radical abstraction which, at the beginning of the 20th century, preceded Kandinsky, Malevich, Mondrian. Yet, where much attention has been given to the symbology and motifs riddling Klint’s work – bold, private, untethered and nonrepresentational as they are – there has been a modicum of nuanced thought on how, exactly, esotericism and theology fomented (...) Klint’s pedagogical projects. Jillian Steinhauer, for instance, has underscored Klint’s naturalistic watercolors; featuring flowers and lifelike drawings of women; Summer Landscape (1888) suggests Klint’s technical aptitude for rendering light. Jadranka Ryle, in a clever article titled “Reinventing the Yggdrasil,” invokes Klint’s motif of the Yggdrasil, or the holy tree of Norse mythology, as a political axle for Nordic romanticism. Ryle makes the claim that by redirecting the Yggdrasil towards androgynous abstraction, Klint’s engagement with Norse mythology subverts the nationalist and patriarchal romanticism that previously characterized the nineteenth century’s use of the Yggdrasil. Others have adroitly uncovered biographical fragments from Klint’s life, detailing how she and four friends formed De Fem (“the Five”), an exclusively female coven that met weekly, praying, meditating, and holding seances to commune with spiritual guides. Rather than poise the Swedish maverick within the cannon of abstraction qua a political praxis, feminist subject-being, or historiography – projects that have been exhaustively overwrought, to the point of rendering Klint’s work both mute and reductively technical– I would like to take this time to closely examine simply one of Klint’s paintings and foreground it as an axiomatic modernist injunction between metaphysics and epistemology. (shrink)

Review of Daniel Callahan, The Troubled Dream of Life.

This paper compares the concepts of “spirit” and “dialectic” in Hegel’s Phenomenology of Spirit and Kierkegaard’s The Sickness unto Death respectively. For this purpose, I delve into the way in which both philosophers understand these two concepts. The aim of this comparison is to detect whether there is some kind of relationship between the two concepts that could bring Hegel and Kierkegaard closer to each other.

In this article, I analyze how the Harry Potter novels bring to awareness two fundamental aspects of the human condition: the importance of one’s choices and the inevitability of one’s mortality. These are highlighted through the contrast of the characters of Harry Potter and Lord Voldemort.

Despite confident assertions by science and religion, no one can be absolutely certain what is going on in this drama we call existence. We are haunted by the realization that we are finite, vulnerable, mortal, and perhaps meaningless creatures. The ambiguity in all experience leaves us in a state of fundamental uncertainty, with a buried anxiety underlined by fear of mortality. However, the ability to consider consciousness as a personal creation enables us to appreciate experience for its own sake, (...) despite uncertainty and anxiety. It is the basis of art, and also of tolerance, epistemic responsibility, and the creative ability to think, perceive, and act outside the box. (shrink)

Este artículo explora ciertas conexiones entre la representación de la mortalidad en el retrato y el tratamiento filosófico de nuestra necesidad de ser reconocidos por los demás. En primer lugar, se examina la conexión que establece Georg Simmel en su estudio filosófico sobre Rembrandt entre la capacidad del artista para representar en sus retratos individuos irrepetibles, y su capacidad para capturar la finitud de los mismos en tanto que seres mortales. Tras señalar que ninguna de las explicaciones de Simmel sobre (...) el carácter trágico de los sujetos de los retratos de Rembrandt resulta completamente satisfactoria, recupero los escritos de Rousseau sobre nuestra necesidad de ser reconocidos por los otros, para argumentar que consideramos que los otros son insustituibles porque son capaces de satisfacer esta necesidad ; y que es, precisamente, a esta clase de insustituibilidad a la que apunta Simmel al enlazar los conceptos de individualidad y mortalidad en sus escritos sobre los retratos de Rembrandt. A partir de este punto, sostengo que las ideas anteriores son, de hecho, centrales para la comprensión de la escritura psicoanalítica de Melanie Klein, y, en particular, al planteamiento de Klein sobre la percepción de las otras personas por parte de los niños, que relaciona con sus ansiedades acerca de la posibilidad de la pérdida irreparable de esas personas; su planteamiento de que la condición de persona del otro se debe a que los percibimos como fuentes de reconocimiento; y su análisis de la pintura de retratos como una actividad con la que abordar estas ansiedades. (shrink)

Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the limits (...) of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

Emmanuel Levinas’s work seemingly places a great emphasis on language leading some commentators towards a Kantian reading of him where moral consideration would be based on the moral patient’s capacity for reason with language functioning as a proxy for this. Although this reading is possible, a closer look at Levinas’s descriptions of language reveal that its defining characteristic is not reason but the capacity to express beyond any thematized contents we would give to the Other. This expressivity (which Levinas calls (...) face) would confront me with their singularity, infinity, and interiority tying me to them in a relation of responsibility. And the “content” of such an expression is a vulnerability and exposure tied to their mortality which continually entreats me though I cannot take it away. It is by means of this bare expression of an exposure to death as the core of language that it will become possible for non-human mortal beings to have what Levinas calls language. This possibility, although not explicitly addressed by Levinas, is at least left open by his account of Bobby the dog as well as his agnosticism over a snake’s face. (shrink)

Objectives: The aim of this study is to find out the prevalence and outcome of falciparum malaria with neurological manifestations. Materials and Methods: A prospective cross-sectional hospital-based study of 318 falciparum malaria patients using simple, direct, standardized questionnaire with history, lab investigations and neurological examination from January 2014 to December 2014. Results: July was the most vulnerable month for falciparum malaria causing the highest hospital admission (48.8%) and death (29.3%). The commonest age group affected was 15- 30 years (49.2%). Prevalence (...) of neurological manifestations was 58.8%. Altered sensorium (48.7%) was the most frequent neurological manifestation, followed by abnormal behavior (19.8%) and convulsions (15.5%). Case fatality rate was very high with neurological manifestations, highest with altered sensorium (31.3%). Only 71.1% knows about the neurological manifestations showing very poor perception among tribal. Primary health care providers also failed to diagnose most of the cases (69%) which presented with neurological features. Conclusion: Falciparum malaria with neurological involvement is associated with increased mortality. By documenting different neurological patterns of falciparum malaria and by trained health care personnel, mortality and morbidity rates can be reduced by early diagnosis and management. (shrink)

With the further growth of the world population and the further intensification of the processes of interaction between countries and increasing movements of the masses of people, the role of Political Demography becomes more and more important. Issues of global ageing, migration, low fertility in developed countries (or very high fertility in some African countries), high mortality in many developing states (including deaths from AIDS); rapid change in the ethnic composition in Europe and in several other regions and many (...) other pressing issues are in the focus of this discipline. Some of these problems are analyzed in this yearbook. However, among those issues, the issue of global ageing becomes more and more pressing every year. It is sufficient to take into account the point that within two forthcoming decades a rapid global increase in the number of retirement-age persons will lead to its doubling within this fairly small historical period. The concerns about population ageing apply to both developed and many developing countries and it has turned into a global issue. In the next decades the population ageing is likely to become one of the most important processes determining the future society characteristics and directions of technological development. (shrink)

Mortality seems important in explaining the value of virtues. It seems that courage is valuable because we face dangers of death and pain, just as it seems temperance is valuable because we can harm our health by overindulgence. This poses a serious problem for Christian ethics. If the virtues are valuable because they ameliorate harms stemming from limitations like mortality, then the virtues will lose much of their value in the new creation, where those limitations are no more. (...) This chapter argues that the threat is serious, and requires the rethinking of the fundamental value of the virtues. The virtues are not, first and foremost, the dispositions that allow us to improve the broken world we live in, but precisely those dispositions necessary for enjoying ideal or perfect conditions. (shrink)

Throughout history no mere mortal has been more revered and esteemed by so many diverse people than Abraham, great patriarch of the three enduring monotheistic religions. Yet Judaism, Christianity and Islam all agree that this man attempted to kill his own, innocent son, an act so dastardly that it would normally be judged both immoral and illegal in any civil society. Surprisingly, the scriptures of these three religious faiths praise Abraham for this very act, justifying it in very different ways, (...) but all portraying it as the paradigm of religious obedience. (shrink)

This essay explores the psychological freedom that emerges from the acceptance of death, arguing that it should not be seen as merely a one-sided freedom of death without the complementary freedom of life. While death is often met with dread and fear, it can foster a sense of authenticity and alignment with personal values. However, this realization must also emphasize the importance of life, as the goal of psychological well-being lies in living, not just acknowledging death. This balance allows us (...) to live fully, prioritize meaningful experiences, and discard trivial concerns. By drawing on Carl Sagan’s reflections on humanity’s insignificance within the cosmos, this essay encourages empowered and responsible living that embraces both life and death. (shrink)

Self-medication of antibiotics is an irrational use of drugs, contributing to microbial resistance, increasing healthcare costs and higher mortality and morbidity. This study aimed to assess self-medication with antibiotics without a medical prescription in the community of Libya. This is a cross-sectional study conducted from June to December 2022 and the total number of participants was 200. The design of the study and sample size were modified according to the proficiency of pharmacists and the medical and non-medical population of (...) Libya. The questionnaire was developed in English and Arabic language and was distributed through social media platforms. The questions were used after a thorough literature search and assessing the validity and reliability. The significant signs regarding reasons for the treatment by self-medication drugs of antibiotics, because of its various drugs of antibiotic by pharmacist (n=80, 40.0%) and family (n=90, 45.0%) compared with experience and physicians by used prescription was 13 (6.50%) and significant sings regarding by nasal congestion self-medication of various antibiotics (n=100, 50.0%). This sign must be practiced based on a previous physician’s prescription. The antibiotics are often self-administered as patients feel that they will save money and time but this can lead to substantial adverse drug reactions, antibiotic resistance, treatment failure and drug-related toxicity. This study respondent's medical and non-medical public of Libya who should be relatively informed and educated about the risk of treatment by self-medication of antibiotics with the development of resistance. (shrink)

This essay frames systemic patterns of mental abuse against women of color and Indigenous women on Turtle Island (North America) in terms of larger design-of-distribution strategies in settler colonial societies, as these societies use various forms of social power to distribute, reproduce, and automate social inequalities (including public health precarities and mortality disadvantages) that skew socio-economic gain continuously toward white settler populations and their descendants. It departs from traditional studies in gender-based violence research that frame mental abuses such as (...) gaslighting--commonly understood as mental manipulation through lying or deceit--stochastically, as chance-driven interpersonal phenomena. Building on structural analyses of knowledge in political epistemology (Dotson 2012, Berenstain 2016), political theory (Davis and Ernst 2017), and Indigenous social theory (Tuck and Yang 2012), I develop the notion of cultural gaslighting to refer to the social and historical infrastructural support mechanisms that disproportionately produce abusive mental ambients in settler colonial cultures in order to further the ends of cultural genocide and dispossession. I conclude by proposing a social epidemiological account of gaslighting that a) highlights the public health harms of abusive ambients for minority populations, b) illuminates the hidden rules of social structure in settler colonial societies, and c) amplifies the corresponding need for structural reparations. (shrink)

Theoretical frameworks concerning cell fate typically center on proximate causes to explain how cells know what type they are meant to become. While major advances in cell fate theory have been achieved by these mechanism-focused frameworks, there are some aspects of cell decision-making that require an evolutionary interpretation. While mechanistic biologists sometimes turn to evolutionary theory to gain insights about cell fate (cancer is a good example), it is not entirely clear in cell fate theory what insights evolutionary theory can (...) add, and why in some cases it is required for understanding cell fate. In this perspective we draw on our work on cellular mortality to illustrate how evolutionary theory provides an explanation for death being selected as one of the potential cell fates. Using our hypothesis for why some microbes in a community choose death as their fate, we suggest that some insights in cell fate theory are inaccessible to a theoretical framework that focuses solely on proximate causes. (shrink)

Cardiovascular diseases (CVD) represent a significant cause of morbidity and mortality worldwide, necessitating early detection for effective intervention. This research explores the application of machine learning (ML) algorithms in predicting cardiovascular diseases with enhanced accuracy by integrating optimization techniques. By leveraging data-driven approaches, ML models can analyze vast datasets, identifying patterns and risk factors that traditional methods might overlook. This study focuses on implementing various ML algorithms, such as Decision Trees, Random Forest, Support Vector Machines, and Neural Networks, optimized (...) through techniques like hyperparameter tuning, cross-validation, and feature selection to improve prediction accuracy. (shrink)

Some bioethicists argue that a doctor may frame treatment options in terms of effects on survival rather than on mortality in order to influence patients to choose the better option. The debate over such framing typically assumes that the survival and mortality frames convey the same numerical information. However, certain empirical findings contest this numerical equivalence assumption, demonstrating that framing effects may in fact be due to the two frames implying different information about the numerical bounds of survival (...) and mortality rates. In this paper, I use these findings to argue that framing is presumptively wrong because it violates the duty of proper disclosure. Along the way, I highlight morally relevant features affecting the permissibility of framing, tackle three objections and draw some general lessons for the ethics of nudging. (shrink)

I defend Haze’s argument against the Breckenridge-Magidor theory of instantial reasoning from an objection by Meléndez Gutiérrez. According to Breckenridge and Magidor, in reasoning like ‘Some x is mortal. Let n be such an x…’, the ‘n’ refers to a particular object but we cannot know which. This surprisingly defensible view poses an obvious threat to widespread notions in the philosophy of language. Haze argues that the theory leads to absurdity in cases like ‘Some x is unreferred-to by any expression. (...) Let n be such an x…’ and should therefore be rejected. Meléndez Gutiérrez counters that Haze’s argument is just a case of Berry-like paradox and thus fails to refute the Breckenridge-Magidor theory. I argue that the analogy breaks down: unlike the intuitively compelling and widely believed well-ordering principle about positive integers, the principle drawn from Breckenridge and Magidor that plays a supposedly analogous role enjoys no such status, and is instead simply shown to be false by Haze’s reductio. The possibility of such a response is obscured when Meléndez Gutiérrez portrays Haze’s argument as involving a stipulation that ‘n’ is to refer to an unreferred-to object. On the contrary, Haze’s argument does not assume that expressions like ‘n’ work by means of referring at all, and simply lets stipulations like ‘Let n be such an x’ be themselves, without imposing a theory on them. Once this is clarified, we can see that Haze’s argument is unaffected by Meléndez Gutiérrez’s objection. (shrink)

In bioethics, the predominant categorization of various types of influence has been a tripartite classification of rational persuasion (meaning influence by reason and argument), coercion (meaning influence by irresistible threats—or on a few accounts, offers), and manipulation (meaning everything in between). The standard ethical analysis in bioethics has been that rational persuasion is always permissible, and coercion is almost always impermissible save a few cases such as imminent threat to self or others. However, many forms of influence fall into the (...) broad middle terrain—and this terrain is in desperate need of conceptual refining and ethical analysis in light of recent interest in using principles from behavioral science to influence health decisions and behaviors. This paper aims to address the neglected space between rational persuasion and coercion in bioethics. First, I argue for conceptual revisions that include removing the “manipulation” label and relabeling this space “nonargumentative]influence,” with two subtypes: “reason-bypassing” and “reason-countering.” Second, I argue that bioethicists have made the mistake of relying heavily on the conceptual categories themselves for normative work and instead should assess the ethical permissibility of a particular instance of influence by asking several key ethical questions, which I elucidate, that relate to (1) the impact of the form of influence on autonomy and (2) the relationship between the influencer and the influenced. Finally, I apply my analysis to two examples of nonargumentative influence in health care and health policy: (1) governmental agencies such as the Food and Drug Administration (FDA) trying to influence the public to be healthier using nonargumentative measures such as vivid images on cigarette packages to make more salient the negative effects of smoking, and (2) a physician framing a surgery in terms of survival rates instead of mortality rates to influence her patient to consent to the surgery. (shrink)