Interlevel Relations in Science

Background: Exposomics, the study of the exposome, is flourishing, but the field is not well defined. The term “exposome” refers to all environmental influences and associated biological responses throughout the lifespan. However, this definition is very similar to that of the term “environment”—the external elements and conditions that surround and affect the life and development of an organism. Consequently, the exposome seems to be nothing more than a synonym for the environment, and exposomics a synonym for environmental research. As a (...) result, some have rebranded their “standard” environmental health research with the neologistic exposome term, whereas others ignore or seek to abandon the seemingly redundant concept of the exposome. -/- Objectives: We argue that exposomics needs to sharpen its mission focus to counteract this apparent redundancy. Exposomics should be defined as a research program in environmental health aimed at enabling a comprehensive and discovery-driven approach to identifying environmental determinants of human health. Similar to the aim of the Human Genome Project, exposomics aims to analyze the complete complexity of exposures and their corresponding biological responses. Exposomics’ primary premise is that the existence of undiscovered, potentially interconnected, nongenetic (environmental) risk factors for health necessitates a comprehensive discovery-driven analysis approach. -/- Discussion: We argue that exposomics researchers should adopt our reconceptualization of exposomics and focus on the productiveness and integrity of their research program: its purpose and principles. We suggest that exposomics researchers should coordinate the writing of reviews that assess the program’s productiveness and integrity, as well as provide a platform for exposomics researchers to define their vision for the field. (shrink)

In this article I examine several related views expressed by Robin Hendry concerning molecular structure, emergence and chemical bonding. There is a long-standing problem in the philosophy of chemistry arising from the fact that molecular structure cannot be strictly derived from quantum mechanics. Two or more compounds which share a molecular formula, but which differ with respect to their structures, have identical Hamiltonian operators within the quantum mechanical formalism. As a consequence, the properties of all such isomers yield precisely the (...) same calculated quantities such as their energies, dipole moments etc. The only means through which the difference between the isomers can be recovered is to build their structures into the quantum mechanical calculations, something that is carried out by the application of the Born-Oppenheimer approximation. Consequently, it has been argued by many authors that molecular structure is written in ‘by hand’ rather than derived. Robin Hendry is one such author, but he goes a great deal further by proposing that this situation implies the existence of emergence and downward causation. In the current article I argue that there are alternative explanations which render emergence and downward causation redundant. Such an alternative lies in the notion of quantum decoherence and the appeal to work in the foundations of physics, which posits that the various isomers exist as a superposition until their wavefunctions are collapsed either by observation or by interacting with their environment. Hendry also alludes to a debate among chemists as to whether chemical bonds are real or not, in the sense of directional connections between two or more nuclei in any given molecule. I reject this view and propose that the structural and energetic views of chemical bonding, that have been discussed by some philosophers of chemistry including Hendry, do not refer to any essential ontological differences. I agree that chemists view bonding in a more realistic fashion and may consider bonds to be in some senses real, while physicists may consider bonding in more abstract energetic terms. However, I do not believe that such differences in scientific practice and attitudes should be considered to offer a window as to the ontological status of bonding or whether bonding is real. Finally, I discuss the kinetic energy school of chemical bonding which would seem to challenge any notion of bonds as directional entities, since bonding is no longer regarded as being primarily due to the build-up of electron density between nuclei. (shrink)

When introduced around 1925, interdisciplinarity, grounded in the notion of the unity of knowledge, was meant to reconnect the fragmented and specialized disciplines of academia. However, interdisciplinary research became more and more challenging as the plurality and heterogeneity of disciplinary perspectives and insights increased. Insisting on this divergence and diversity, Julie Thompson Klein has nonetheless contributed in important ways to convergence in interdisciplinarity with her work on the process of integration as interdisciplinarity's defining feature. Of course, she is aware that (...) the increasing inclusion of extra-academic stakeholders in transdisciplinary research constitutes a fundamental challenge to integrative interdisciplinarity. This challenge implies that next to academic contributions, experiential knowledge, interests, and norms must be recognized as valuable to the process, and stakeholder expectations of applicable results must be met. Exploring the future by extending this crucial development further, this article focuses on the actionability of knowledge as an additional criterion for effective interdisciplinarity and transdisciplinarity, as it is in Action Research. With action options for stakeholders being an important goal for such research, it is argued that joint deliberation about these options must be part of the process, aiming for reflective equilibrium. At the same time, an important role for imagination is defended, enabling adequate consideration of action options with their ramifications and implications. The future of interdisciplinarity, it is concluded, will entail an important role for the actionability criterion and for the related role of imagination of potential outcomes, much greater roles than these now have. (shrink)

A commissioned 3-volume (800 pages) in-depth introduction to the philosophy of science, peer-reviewed by 11 specialists. (In Hebrew).

This dissertation argues that cognition is a kind of natural agency. Natural agency is the capacity that certain systems have to act in accordance with their own norms. Natural agents are systems that bias their repertoires in response to affordances in the pursuit of their goals. Cognition is a special mode of this general phenomenon. Cognitive systems are agents that have the additional capacity to actively take their worlds to be certain ways, regardless of whether the world is really that (...) way. In this way, cognitive systems are desituated. Desituatedness is the root of specifically cognitive capacities for representation and abstraction. There are two main reasons why this view needs defending. First, natural agency is typically viewed as incompatible with natural science because it is committed to a teleological mode of explanation. Second, cognition is typically held to be categorically distinct from natural agency. This dissertation argues against both of these views. It argues against the incompatibility of agency and natural science by demonstrating that systems biology, general systems theory, and sciences that deal with complex systems have typically underappreciated conceptual and theoretical resources for grounding agency in the causal structure of the world. These conceptual resources do not, however, reduce agency to systems theory because the normativity inherent in agency demands descriptive resources beyond those of even the most sophisticated systems theory. It argues against the categorical difference between natural agency and cognition by pointing out that separating cognition from a richer web of situated, ecologically embedded relations between the agent and the world generates the frame problem, which is an insuperable obstacle to making cognition that is sufficiently responsive to the complexity of the world. Rooting cognition in natural agency is a more robust empirical bet for theorizing cognition and artificial intelligence. (shrink)

This article considers two important traditions concerning the chemical elements. The first is the meaning of the term “element” including the distinctions between element as basic substance, as simple substance and as combined simple substance. In addition to briefly tracing the historical development of these distinctions, I make comments on the recent attempts to clarify the fundamental notion of element as basic substance for which I believe the term “element” is best reserved. This discussion has focused on the writings of (...) Fritz Paneth which are here analyzed from a new perspective. The other tradition concerns the reduction of chemistry to quantum mechanics and an understanding of chemical elements through their microscopic components such as protons, neutrons and electrons. I claim that the use of electronic configurations has still not yet settled the question of the placement of several elements and discuss an alternative criterion based on maximizing triads of elements. I also point out another possible limitation to the reductive approach, namely the failure, up to now, to obtain a derivation of the Madelung rule. Mention is made of some recent similarity studies which could be used to clarify the nature of ‘elements’. Although it has been suggested that the notion of element as basic substance should be considered in terms of fundamental particles like protons and electrons, I resist this move and conclude that the quantum mechanical tradition has not had much impact on the question of what is an element which remains an essentially philosophical issue. (shrink)

This essay outlines a hierarchical framework of Reality that allows for degrees of Reality. I use Reality (with a capital “R”) to designate reality in a primitive, metaphysical sense. Reality, grounding, and essence are the key elements of the framework presented here. I assume that Reality must have a fundamental level and all fundamental phenomena must be Real. Moreover, I postulate that everything non-fundamental is ultimately grounded in the fundamental Real. But what about the Reality of the non-fundamental? I argue (...) that it is possible for non-fundamental phenomena to be Real, Unreal, or Semi-Real. The framework developed here accommodates these possibilities and illuminates them using the notion of essence. I argue that the essential nature of a phenomenon determines its degree of Reality. The framework does not assume that Reality must have degrees but only that it may have degrees. Its theoretical attractiveness consists in its ability to accommodate many diverse intuitions about grounding, help us better understand and classify theories about grounding, and illuminate Reality and its possible degrees. (shrink)

It is not unusual among particle physicists to find the belief that elementary particles and forces determine everything in physics, chemistry, biology, geology, physiology all the way up to human behaviour. It is not just that physics underlies everything in the universe; it is the belief that everything in the universe reduces to the play of elementary particles under forces. Yet, there are other physicists who argue that this is an oversimplification of the relationship between physics and other domains. This (...) book explores these debates and proposes a physics-motivated conception of emergence that leaves behind many of the problematic intuitions shaping the philosophical conceptions. It would be suitable for physicists, scientists, undergraduate and postgraduate science students interested in reduction and emergence debates. (shrink)

Functional reductionism characterises inter-theoretic reduction as the recovery of the upper-level behaviour described by the reduced theory in terms of the lower-level reducing theory. For instance, finding a statistical mechanical realiser that plays the functional role of thermodynamic entropy allows for establishing a reductive link between thermodynamics and statistical mechanics. This view constitutes a unique approach to reduction that enjoys a number of positive features, but has received limited attention in the philosophy of science. -/- This paper aims to clarify (...) the meaning of functional reductionism in science, with a focus on physics, to define both its place with respect to other approaches to reduction and its connection to ontology. To do so, we develop and explore two alternative frameworks for functional reduction, called Syntactic Functional Reductionism and Semantic Functional Reductionism. They represent two different possible stances on the view that expand and improve the basic functional reductionist approach along different lines, and make clear how the approach works in practice. The former elaborates on David Lewis’ account, is connected with the syntactic view of theories, is committed to a logical characterisation of functional roles, and is embedded within Nagelian reductionism. The latter adopts a semantic view of theories, spells out functional roles mainly in terms of mathematical roles within the models of theories, and is expressed in terms of the related structuralist approach to reduction. The development of these frameworks has the final goal of advancing functional reductionism, to make it a fully-fledged alternative account for reduction in science. (shrink)

Functionalism is the view that being x is to play the role of x. This paper defends a functionalist account of three-dimensional entities in the context of Wave Function Realism (WFR), that can explain in detail how we can recover three-dimensional entities out of the wavefunction. In particular, the essay advocates for a novel version of WFR in terms of a functional reductionist approach in the style of David Lewis. This account entails reduction of the upper entities to the bottom (...) ones, when the latter behave appropriately. As applied to WFR, it shows how the wavefunction can turn out to be identical to three-dimensional objects, provided certain conditions. The first major goal of the paper is thus to put forward an improved and more rigorous version of WFR, which dissolves several extant issues about the theory, and can serve as a starting point for future literature on the topic. Moreover, the second major goal of the article is to take WFR as a case study to demonstrate the pros of functional reductionism, especially in the form defended here, thereby helping to bring this view back in the philosophy of science debate. The positive upshots of this paper suggest a possible application of functional reductionism also to other contexts. (shrink)

Negli ultimi anni, il richiamo al concetto di emergenza si è fatto sempre più diffuso in molte aree della filosofia e della scienza. Il termine viene usato per riferirsi alla circostanza in cui un sistema (fisico, chimico, biologico, ma anche sociale) manifesta delle proprietà e dei comportamenti che sembrano nuovi rispetto a quelli delle sue parti più semplici. Questo libro si propone di chiarire questo fenomeno, tenendo conto, da un lato, che le discipline coinvolte nel dibattito sono molte, quindi un (...) approccio univoco all'emergenza potrebbe non bastare e, dall'altro, che per comprendere cosa sia l'emergenza è necessario delinearne le relazioni con altre questioni filosofiche di primaria importanza come quelle che coinvolgono la fondamentalità, la complessità e la causalità. (shrink)

Intuitivamente, la realidad está formada por entidades y hechos existentes y concretos. Sin embargo, nuestro lenguaje y pensamiento versa también sobre hechos meramente posibles, sobre cosas inexistentes y entidades abstractas. ¿Cómo es esto posible? ¿Significa ello que cuando hablamos y pensamos de estas otras cosas no hablamos de nada real? ¿o mas bien la realidad está mas poblada de lo que pensábamos y hay diferentes maneras de formar parte de la realidad además de la de existir de manera positiva y (...) concreta? En este libro trataremos de arrojar luz a estas y otras preguntas similares, poniendo atención a las estrategias argumentativas generales que suelen esgrimirse en esta rama de la filosofía. (shrink)

Recent discussions of emergence in physics have focussed on the use of limiting relations, and often particularly on singular or asymptotic limits. We discuss a putative example of emergence that does not fit into this narrative: the case of phonons. These quasi-particles have some claim to be emergent, not least because the way in which they relate to the underlying crystal is almost precisely analogous to the way in which quantum particles relate to the underlying quantum field theory. But there (...) is no need to take a limit when moving from a crystal lattice based description to the phonon description. Not only does this demonstrate that we can have emergence without limits, but also provides a way of understanding cases that do involve limits. (shrink)

Rom Harré thinks that the Emergence–Reduction debate, conceived as a vertical problem, is partly ill posed. Even if he doesn’t wholly reject the traditional definition of an emergent property as a property of a collection but not of its components, his point is that this definition doesn’t exhaust all the dimensions of emergence. According to Harré there is another kind (or dimension) of emergence, which we may call—somewhat paradoxically—“horizontal emergence”: two properties of a substance are horizontally emergent relative to each (...) other if they cannot be displayed in the same conditions. Contrary to vertical emergence, horizontal emergence is a symmetrical relation. Harré endorses horizontal emergentism. I argue that this position faces a principled difficulty: it makes it impossible to bind different horizontally emergent discourses in an interesting way. Physics and biology for example become “island” discourses, each speaking of a distinct kind of entities. The only way to ensure that two different discourses can relate to the same entity is to reintroduce verticality into the picture. (shrink)

Convincing disputes about explanatory reductionism in the philosophy of biology require a clear and precise understanding of what a reductive explanation in biology is. The central aim of this book is to provide such an account by revealing the features that determine the reductive character of a biological explanation. Chapters I-IV provide the ground, on which I can then, in Chapter V, develop my own account of explanatory reduction in biology: Chapter I reveals the meta-philosophical assumptions that underlie my analysis (...) of reduction, Chapter II introduces the previous debate about reduction in the philosophy of biology by pointing out the most crucial lessons one should learn from this debate, Chapter III critically discusses the two perspectives on explanatory reduction that have been proposed in the philosophy of biology so far, and Chapter IV clarifies in what ways the issue of reduction is entangled with the issue of explanation. In Chapter V I present my own account of explanatory reduction. My main claim is that reductive explanations in the biological sciences possess three main characteristics: they explain the behavior of a biological system S, first, exclusively in terms of factors that are located on a lower level of organization than S, second, by focusing on factors that are internal to S , and third, by describing the genuine parts of S only as “parts in isolation”. This account is ontic because it traces the reductivity of an explanation back to certain relations that exist in the world. (shrink)

This paper proposes a classification of the intertheoretic relations in physics by bringing out the conditions for a relation of reduction which is eliminative, so that a theory reduced in terms of reductionism is superfluous in principle, and by distinguishing such a relation from another one based on comparison, which will be called neighbourhood of theories; the latter is a neighbouring relation between theories and is not able to support claims of eliminative reductionism. In the first part, it will be (...) argued that this differentiation between neighbourhood and eliminative reduction permits an adequate classification of the intertheoretic relations in physics. By means of this differentiation, the second part discusses reductionism and shows that there are indeed some historical examples of reduction in the aforementioned sense, but that modern physical theories are typically only neighbouring. (shrink)

The paper sets forth an argument against Kim's distinction between levels and orders.

An entry on the meaning and history of emergence as well as the current debate on emergentism in philosophy and the sciences.

This paper offers a critical assessment of the current state of the debate about the identity and individuality of material objects. Its main aim, in particular, is to show that, in a sense to be carefully specified, the opposition between the Leibnizian ‘reductionist’ tradition, based on discernibility, and the sort of ‘primitivism’ that denies that facts of identity and individuality must be analysable has become outdated. In particular, it is argued that—contrary to a widespread consensus—‘naturalised’ metaphysics supports both the acceptability (...) of non-qualitatively grounded (both ‘contextual’ and intrinsic) identity and a pluralistic approach to individuality and individuation. A case study is offered that focuses on non-relativistic quantum mechanics, in the context of which primitivism about identity and individuality, rather than being regarded as unscientific, is on the contrary suggested to be preferable to the complicated forms of reductionism that have recently been proposed. More generally, by assuming a plausible form of anti-reductionism about scientific theories and domains, it is claimed that science can be regarded as compatible with, or even as suggesting, the existence of a series of equally plausible grades of individuality. The kind of individuality that prevails in a certain context and at a given level can be ascertained only on the basis of the specific scientific theory at hand. (shrink)

In this paper I argue that it is finally time to move beyond the Nagelian framework and to break new ground in thinking about epistemic reduction in biology. I will do so, not by simply repeating all the old objections that have been raised against Ernest Nagel’s classical model of theory reduction. Rather, I grant that a proponent of Nagel’s approach can handle several of these problems but that, nevertheless, Nagel’s general way of thinking about epistemic reduction in terms of (...) theories and their logical relations is entirely inadequate with respect to what is going on in actual biological research practice. (shrink)

Der Aufsatz lotet den zeitgenössischen Reduktionismus aus. Im ersten Teil wird in zentrale Stationen der wissenschaftstheoretischen Debatte um Theorien-Reduktion eingeleitet, wobei das Schaffner-Hooker-Modell und die Bedeutung von Näherungsbegriffen hervorgehoben werden. Der zweite Teil behandelt die multiple Realisierbarkeit als eines der nach wie vor zentralen anti-reduktionistischen Argumente. Die Analyse soll zeigen, dass es sich hierbei nicht um ein einheitliches Phänomen handelt, sondern dass sehr verschiedene Kategorien von Multirealisierbarkeit zu unterscheiden sind. In einem vereinfachten Slogan: multiple Realisierbarkeit ist ihrerseits multirealisiert. Der Aufsatz (...) entwickelt eine rohe Taxonomie von Typen multipler Realisierbarkeit und möglicher reduktionistischer Strategien, wobei genuine Fälle von Multirealisierbarkeit auf geteilte Eigenschaften zurückgeführt werden. Im letzten Teil wird die besondere Rolle von Näherungen im Zusammenhang mit der explanatorischen Spannung zwischen ontischem Reduktionismus und epistemischen Anti-Reduktionismus verdeutlicht. (shrink)

My main reaction to MCGivern’s paper was one of dialectical puzzlement. Block argues that, Macro Non-Reduction: [all] macro properties are irreducible to the micro properties on which they supervene..

Gavagai! or the Future History of the Animal Language Controversy By DAVID PREMACK.

In several places, John Bickle claims that current neuroscientific practice provides actual cellular/molecular reductions of certain mental states. He gives the case study of ‘memory consolidation switch’ as an example where recent findings suggest that this mental state/process can be reduced to the molecular ‘cAMP, PKA, CREB Pathway’. Taking this example, Bickle ‘waves the eleminativist flag’ by claiming that psychological explanations loose their pertinence (or, as he says, ‘became otiose’) once a cellular/molecular explanation replaces them. On this paper I’ll try (...) to show that, even if a reductive explanation of ‘memory consolidation switch’ is disposable, we cannot eschew reductively its causal/functional integrity, i.e.: the explanatory/causal context that defines the mental concept/process ‘memory consolidation switch’ in the first place. (shrink)

There is a strong philosophical intuition that direct study of the brain can and will constrain the development of psychological theory. When this intuition is tested against case studies on the neurophysiology and psychology of perception and memory, it turns out that psychology has led the way toward knowledge of neurophysiology. An abstract argument is developed to show that psychology can and must lead the way in neuroscientific study of mental function. The opposing intuition is based on mainly weak arguments (...) about the fundamentality or objectivity of physics or physiology in relation to psychology. -/- Philosophy of Science, Vol. 67, Supplement. Proceedings of the 1998 Biennial Meetings of the Philosophy of Science Association. Part II: Symposia Papers (Sep., 2000). (shrink)

This is a first tentative examination of the possibility of reinstating reduction as a valid candidate for presenting relations between mental and physical properties. Classical Nagelian reduction is undoubtedly contaminated in many ways, but here I investigate the possibility of adapting to problems concerning mental properties an alternative definition for theory reduction in philosophy of science. The definition I offer is formulated with the aid of non-monotonic logic, which I suspect might be a very interesting realm for testing notions concerning (...) localized mental-physical reduction. The reason for this is that non-monotonic reasoning by definition is about appeals made not only to explicit observations, but also to an implicit selection of background knowledge containing heuristic information. The flexibility of this definition and the fact that it is not absolute, i.e. that the relation of reduction may be retracted or allowed to shift without fuss, add at least an interesting alternative factor to current materialist debates. South African Journal of Philosophy Vol. 25(2) 2006: 102-112. (shrink)

Explanation is a human activity. Teleological, causal, and evolutionary explanations are all valid forms of responding to particular puzzlements. Reductionism incorrectly assumes there is one absolute explanation. While causal explanation appeals primarily to necessity, evolutionary explanation is based largely on contingency.