Se trata de un pequeño libro de Ocean Sur en los marcos de su colección Cuadernos de Formación que, bajo el título genérico de Capitalismo y globalización, contiene el ensayo de José Ramón Fabelo Corzo "Capitalismo versus Vida. Actualidad de lа visión de Marx" y el ensayo de Gilberto Valdés Gutiérrez "Globalización imperialista у sistema de dominación múltiple". La sociedad capitalista, cuya existencia depende de la explotación del trabajo asalariado y de una desenfrenada carrera en pos de (...) la concentración de la riqueza, la propiedad, la producción y el poder político, entró hace décadas en una intensa y suicida fase de destrucción de la naturaleza que, por supuesto, amenaza la extinción de la especie humana. En esta fase, conocida como globalización neoliberal, el imperialismo despliega todos los mecanismos de su sistema de dominación múltiple para evitar la emancipación de la humanidad. (shrink)

El texto constituye una reseña-comentario a dos volúmenes que celebraban desde México, con inteligente selección, abierta a la controversia, el 80 aniversario (1995) del destacado pensador hispano-mexicano. Se trataba de los libros Adolfo Sánchez Vázquez: los trabajos y los días y En torno a la obra de Adolfo Sánchez Vázquez, editados por Federico Álvarez y Gabriel Vargas Lozano, respectivamente. El título del comentario hace alusión a la permanente actitud de principios de Sánchez Vázquez, quien mantuvo, primero, una actitud crítica ante (...) el marxismo ortodoxo y dogmático que se difundía desde la URSS y el llamado socialismo real y, después, asumió estoicamente la defensa del marxismo cuando aquellos habían desaparecido. (shrink)

Se trata de una breve presentación al libro del Investigador Titular del Instituto de Filosofía de La Habana Gilberto Valdés Gutiérrez El paradigma emancipatorio en América Latina: opciones en controversia, publicado por la Benemérita Universidad Autónoma de Puebla.

This paper investigates whether 'even if A, B' is pragmatically polysemic, so that a nonconcessive conditional may have 'even if', and whether concessive conditionals, pragmatically defined, can fail to have 'even if' or a non-temporal 'still'. Different paraphrases are used to help elucidate pragmatic meanings. A theory of the pragmatic meanings of concessive and implicative conditionals is presented. The semantic meaning of 'even if' and the question of whether concessive conditionals imply the truth of their consequents are also discussed.

An extended examination of Libet's works led to a comprehensive reinterpretation of his results. According to this reinterpretation, the Minimum Train Duration of electrical brain stimulation should be considered as the time needed to create a brain stimulus efficient for producing conscious sensation and not as a basis for inferring the latency for conscious sensation of peripheral origin. Latency for conscious sensation with brain stimulation may occurafterthe Minimum Train Duration. Backward masking with cortical stimuli suggests a 125-300 ms minimum value (...) for the latency for conscious sensation of threshold skin stimuli. Backward enhancement is not suitable for inferring this latency. For determining temporal relations between stimuli that correspond to subjects' reports, theendof cerebral Minimum Train Duration should be used as reference, rather than its onset. Results of coupling peripheral and cortical stimuli are explained by a latency after the cortical Minimum Train Duration, having roughly the same duration as the latency for supraliminal skin stimuli. Results of coupling peripheral stimuli and stimuli to medial lemniscus (LM) are explained by a shorter LM latency and/or a longer peripheral latency. This interpretation suggests a 230 ms minimum value for the latency for conscious sensation of somatosensory near-threshold stimuli. The backward referral hypothesis, as formulated by Libet, should not be retained. Long readiness potentials preceding spontaneous conscious or nonconscious movements suggest that both kinds of movement are nonconsciously initiated. The validity of Libet's measures of W and M moments (Libet et al., 1983a) is questionable due to problems involving latencies, training, and introspective distinction of W and M. Veto of intended actions may be initially nonconscious but dependent on conscious awareness. (shrink)

It is argued that contraposition is valid for a class of natural language conditionals, if some modifications are allowed to preserve the meaning of the original conditional. In many cases, implicit temporal indices must be considered, making a change in verb tense necessary. A suitable contrapositive for implicative counterfactual conditionals can also usually be found. In some cases, the addition of certain words is necessary to preserve meaning that is present in the original sentence and would be lost or changed (...) in the contrapositive without them. A distinction is made between adding new meaning and adding new words to preserve existing meaning. For concessive conditionals and relevance conditionals, however, no valid contrapositive can be found. They do not belong to the class of contraposable conditionals, which can be independently defined. Difficult cases are also discussed in which the contradictory of the consequent semantically entails the truth of the antecedent. In such cases the content of the antecedent is implicit in the meaning of the consequent. Contraposition becomes possible if what is implicit in the original consequent is made explicit in the contrapositive antecedent. (shrink)

1. Introduction The readiness potential was found to precede voluntary acts by about half a second or more (Kornhuber & Deecke, 1965). Kornhuber (1984) discussed the readiness potential in terms of volition, arguing that it is not the manifestation of an attentional processes. Libet discussed it in relation to consciousness and to free will (Libet et al. 1983a; 1983b; Libet, 1985, 1992, 1993). Libet asked the following questions. Are voluntary acts initiated by a conscious decision to act? Are the physiological (...) facts compatible with the belief that free will determines our voluntary acts? What is the role of consciousness in voluntary action? In this paper I will discuss these questions and the answers that Libet gave to them. (shrink)

Claims that necessary and sufficient conditions are not converse relations are discussed, as well as the related claim that If A, then B is not equivalent to A only if B . The analysis of alleged counterexamples has shown, among other things, how necessary and sufficient conditions should be understood, especially in the case of causal conditions, and the importance of distinguishing sufficient-cause conditionals from necessary-cause conditionals. It is concluded that necessary and sufficient conditions, adequately interpreted, are converse relations in (...) all cases. (shrink)

Libet's (2000) arguments in defense of his interpretation of his experimental results are insufficient. The claims of my critical review (Gomes, 2008) do not suffer with his new statements.

A commentary on articles by Klein, Pockett, and Trevena and Miller, in this issue, is given. Average shift in the point of subjective equality , calculated by Klein on Libet's data, and corresponding change in mean shift, calculated by Libet et al. , may be “corrected,” taking as a reference point the end of the minimum train duration. Values obtained, if significant, indicate a latency for conscious sensation of the skin stimulus of at least 230 ms. Pockett's main conclusions are (...) favored, but her explanation of peripheral–lemniscal couplings is found to be unconvincing. Trevena and Miller's article unsuccessfully tries to rescue a dualist interactionist view. Libet's method of timing intentions is thoroughly criticized. (shrink)

There are compelling reasons to believe that musical works are abstract. However, this hypothesis conflicts with the platitude that musical works are appreciated by means of audition: the things that enter our ear canals and make our eardrums vibrate must be concrete, so how can musical works be listened to if they are abstract? This question constitutes the audibility problem. In this paper, I assess Julian Dodd’s elaborate attempt to solve it, and contend that Dodd’s attempt is unsuccessful. Then I (...) discuss what I take to be the ideal response to the audibility problem, and show that it ultimately fails. I contend, consequently, that the project of construing musical works as audible is disheartening. Accordingly, in my last section, I will argue the audibility problem may be satisfactorily resolved without ascribing audibility to musical works. (shrink)

The free will problem is defined and three solutions are discussed: no-freedom theory, libertarianism, and compatibilism. Strict determinism is often assumed in arguing for libertarianism or no-freedom theory. It assumes that the history of the universe is fixed, but modern physics admits a certain degree of randomness in the determination of events. However, this is not enough for a compatibilist position—which is favored here—since freedom is not randomness. It is the I that chooses what to do. It is argued that (...) the core of the free will problem is what this I is. A materialist view is favored: The I is an activity of the brain. In addition to absence of external and internal compulsion, freedom involves absence of causal sufficiency of influences acting on the I. A more elaborate compatibilist view is proposed, according to which causal determination is complete when we add events occurring in the I (of which the subject is not conscious). Contrary to what several authors have argued, the onset of the readiness potential before the decision to act is no problem here. The experience of agency is incomplete and fallible, rather than illusory. Some consequences of different views about freedom for the ascription of responsibility are discussed. (shrink)

En el ámbito de la teoría general de la relatividad (TGR), se considera que el espaciotiempo es una entidad real. En este sentido, atendiendo al realis mo sobre entidades, surgen problemas como ¿qué tipo de entidad es el espaciotiempo?, ¿cuál es su naturaleza? Tradicionalmente, en atención a dicha teoría conviven dos concepciones realistas: la substancialista, donde el espaciotiempo sería una substancia; y la relacionista, tal que el espaciotiempo correspondería a una “relación entre substancias”.

An examination of conditionals in di¤erent languages leads to a distinction of three types of conditionals instead of the usual two (indicative and subjunctive). The three types can be explained by the degree of acceptance or as-if acceptance of the truth of the antecedent. The labels subjunctive and indicative are shown to be inadequate. So-called indicative conditionals comprise two classes, the very frequent uncertain-fact conditionals and the quite rare accepted-fact conditionals. Uncertain-fact conditionals may have a time shift in contemporary English (...) and the future subjunctive in Portuguese (though not all of them do). Moreover, paraphrases of if with in case or supposing are usually possible with approximately the same meaning. Accepted-fact conditionals never have these features. (shrink)

Hodgson’s (Journal of Consciousness Studies, 12 (1), 2005) defense of the plain person’s view that free will exists in conscious voluntary action is discussed. His position against the view that human action is automatically determined is favored, but his view that free will is incompatible with natural causation is countered. Eccles’ hypothesis to account for the presence of a readiness potential prior to a conscious decision to act now is discussed. It is argued that it is possible to preserve what (...) is good in a plain person’s concept of free will in a way that is compatible with natural causation. (shrink)

In a provocative article published in the Journal of Consciousness Studies, Susan Pockett argues for the plausibility of considering consciousness as an epiphenomenon of neural activity. This means that consciousness, though caused by the brain, would not in its turn have any role in the causation of neural activity and, consequently, of behaviour. Critical for her argument is the distinction she makes between 'consciousness per se' and 'the neural processing that accompanies it' . In her discussion, though, the author begs (...) the question concerning whether there really is such 'consciousness itself, as distinct from the neural processing that goes with it' . If consciousness as it exists happens not to be distinct from some sort of neural processing, then Pockett's 'consciousness per se' has no causal effect simply because it does not exist. (shrink)

The prima facie heterogeneity between psychical and physical phenomena seems to be a serious objection to psychoneural identity thesis, according to many authors, from Leibniz to Popper. It is argued that this objection can be superseded by a different conception of consciousness. Consciousness, while being conscious of something, is always unconscious of itself . Consciousness of being conscious is not immediate, it involves another, second-order, conscious state. The appearance of mental states to second-order consciousness does not reveal their true nature. (...) Psychoneural identity can thus be considered a valid hypothesis. Related views of Kant, Freud, Shaffer, Bunge and others are considered. “Naive psychical realism” is criticised. Consciousness of mental events is considered as the result of the action of a cerebral system that observes the neural events hypothetically identical to mental events. The theory combines a materialist view with a due consideration of subjective experience. (shrink)

Reinterpretations of Libet's results have received support from most commentaries. Libet's arguments against alternative hypotheses are contested. Latency depends on intensity. Integration of intensity and duration explains the Minimum Train Duration. Analogies of Libet's timing of intentions with control experiments indicate biases of opposite signs, according to intramodal or intermodal results. Rosenthal's view of nonconscious intentions becoming conscious after a delay is favored. Compatibilist free will is discussed.

A commentary is given on Trevena and Miller . The comparability of their experimental task and of the potential they recorded with those used and recorded by Libet, Gleason, Wright, and Pearl is questioned. An interpretation is given for the similarity of event-related potentials recorded when subjects decided to move and when they decided not to move.

Aunque una filosofía de la esperanza pareciera ser una propuesta del todo contemporánea (Bloch, Fromm, Husserl, Laín, Marcel, Heidegger, Patočka, Stein), sus esbozos tuvieron lugar en el siglo VI a.n.e. El objetivo principal de esta investigación es exponer los ejercicios preliminares en torno a una filosofía de la esperanza en el marco de la controversia de Heráclito con Pitágoras. Desde un enfoque cualitativo, mediante el método histórico hermenéutico, se hizo un análisis de datos. Como muestra tomamos fuentes primarias sobre los (...) Versos dorados de Pitágoras y los Fragmentos de Heráclito y como secundarias las traducciones y comentarios más reconocidos. El instrumento utilizado fue las fichas de trabajo mixtas. Como resultado, se observa que la esperanza es un problema para el pueblo griego, que en los vv. 52-53 de los Versos dorados y en el fragmento 22B 18 DK se encuentra esbozada como problema filosófico, que este se comprende mejor a partir de la crítica de Heráclito a Pitágoras y en relación con otros fragmentos clave del pensamiento del Efesio. La investigación permite concluir que la esperanza no es un tema exclusivo de la teología ni propiamente contemporáneo, sino inicialmente de la filosofía, que encuentra en el debate de Heráclito con Pitágoras sus formulaciones preliminares y un contexto propicio para problematizarla en su comprensión habitual, repensarla a la luz del espíritu del tiempo y resignificarla como forma-de-vida. (shrink)

Varzi (2005) discussed 6 ways of symbolizing the sentence 'If Alf went to the movies then Beth went too, but only if she found a taxi-cab.' In the present reply, a seventh symbolization is offered, along with an analysis of the six alternatives discussed by Varzi.

The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Conditional assertions are a peculiar language structure that manifests a specific cognitive operation. In order to express it, different languages have found different ways of using verb forms. Primary conditionals are here defined as those that presuppose the possibility of the falsity of both the antecedent and the consequent. In them, the truth of the antecedent appears as a sufficient condition for the truth of the consequent. The truth condition of primary conditionals is defined as the impossibility of the conjunction (...) of the truth of the antecedent with the falsity of the consequent. The demand for a connection between antecedent and consequent, expressed by Chrysippus as the incompatibility between the affirmation of the antecedent and the denial of the consequent, is thus satisfied. Counterfactuals are conditionals that speak of some aspect of reality through the imagination of an unreal situation. (shrink)

While agreeing with Fischborn’s (2018) contention that, according to one traditional definition of compatibilism, my position should be classified as that of a libertarian incompatibilist, I argue here for a different view of compatibilism. This view involves, on the one hand, local probabilistic causation of decisions (rather than universal strict determinism) and, on the other, free will conceived as involving decisions generated by a decision-making process carried out by the brain, which consciously contemplates different alternatives and could in principle have (...) been different from what it was, implying that the agent could in normal conditions have done otherwise in the same circumstances. After discussing different views of causation (including determinism) and of free will, I make a revision of some passages from my earlier work, quoted by Fischborn. I conclude that what is crucial in the question of (in)compatibilism is the (in)compatibility between freedom of decisions and natural causation of human actions. According to this looser and, I argue, more pertinent view of compatibilism, I maintain my previous classification of my position on the matter as compatibilist. (shrink)

The rationality of the human being applied in science-technique in the contemporary capitalist system is distorted; the purpose, which is the good life for human beings, has become the means to sustain and feedback the technicist system of technological capitalism. Thus, the modus operandi of science, aims only to legitimize technology, apart from the ethics applied in this relationship between technology and human beings, and cut off from critical philosophical thinking. With the result presented, the problem lies in the reason (...) of the contemporary human being, who seeks to satisfy his desires and envisions the good life (eudaimonía) in material goods, suppressing the contemplative leisure of life (ataraxia); becoming a slave to the system it fosters. The objective is to demonstrate the need to reformulate the modern system, in order to earn a good life for human beings as a purpose of technical science, which should be the means for this and as technological advances in favor of the quality of human beings. and, not for capitalist reproduction. The research methodology is an exploratory bibliography, exposing and dialoguing with authors on the subject in order to forge our conclusion, that pleads for science-technical that enjoys ethics and human reason in favor of eudaimonia. (shrink)

'Consciousness' is used in different ways, but not all of these uses reflect clear concepts. In his target article Christian de Quincey (2006) notes that confusion about consciousness is widespread and sets out to distinguish two main meanings of the word. However, his treatment of the subject is confused and the proposed distinction misses the point. I argue that the effort to clarify the meaning of consciousness should proceed in a different direction. We should first find some empirical criterion that (...) allows one to distinguish between being conscious and being unconscious of something in some typical cases. Then we may try to envisage other cases in which a person or animal may be conscious or unconscious of something. Finally, we should try to understand what the difference is between these states. These three lines are developed in this paper. (shrink)

Freedom is often defined by the possibility of doing otherwise. The conditional interpretation of this possibility, advanced by Moore, maintains that to say that someone could have done otherwise is to say that someone would have done otherwise if she had decided to do so. This conception is adequate for the thesis that freedom is compatible with natural causality. The present article presents a defense of this interpretation against the argument with which Lehrer purports to have refuted it. As used (...) in ordinary language, one of the conditionals of the argument has a different sense from that captured in Lehrer’s formalization. In a context that includes the premise that the subject would do otherwise if she decided to do so, the assertion that she could do otherwise only if she decided to do so acquires the meaning that she would do otherwise only if she decided to do so. Without this interpretation, the meaning of ‘can’ in the argument is different from its meaning in ordinary language, since the possibility of doing otherwise would imply really doing otherwise. Abstract in Portuguese: A liberdade é freqüentemente definida pela possibilidade de agir diferentemente. A interpretação condicional dessa possibilidade, proposta por Moore, sustenta que dizer que alguém poderia ter agido diferentemente é dizer que alguém teria agido diferentemente, se assim tivesse decidido. Esta concepção é adequada à tese da compatibilidade entre liberdade e causalidade natural. O presente artigo apresenta uma defesa dessa interpretação contra o argumento com que Lehrer pretendeu contestá-la. Tal como usado na linguagem corrente, um dos condicionais do argumento tem sentido diverso daquele capturado na formalização de Lehrer. No contexto que inclui a premissa de que o sujeito agiria diferentemente se assim decidisse, a afirmaçãode que ele só poderia agir diferentemente se assim decidisse tem o sentido de que ele só agiria diferentemente se assim decidisse. Sem essa reinterpretação, o sentido de ‘poder’, no argumento, distancia-se da linguagem corrente, pois, no caso, poder agir diferentemente implicaria em assim efetivamente agir. (shrink)

This thesis explores the possibility of theoretically conceiving consciousness as an activity of the brain. Objections, based on the concept of qualia, to the identification of consciousness with a brain activity are refuted. Phenomenal consciousness is identified with access-consciousness. Consciousness is conceived as a higher order processing of informational states of the brain. The state of consciousness represents an integration of prior nonconscious states. Libet’s research on the timing of conscious experience is reviewed and analyzed. His hypothesis of backward referral (...) is rejected. Since specific brain activity (the readiness potential) precedes the conscious intention, the implications of this fact on the concepts of volition and free will are discussed. Non-deliberate voluntary acts are performed without a prior consciousness of the intention to perform them. Conversely, the decision to perform a deliberate act is influenced by consciousness of the intention. Free will is viewed as compatible with the causal determination of mental processes. The theory is successfully applied to the different contents of consciousness: consciousness of perceptions, of bodily sensations, of actions, of memories, of ideas, of thoughts, of language, of affective states, of beliefs, of desires, of oneself and consciousness of being conscious. The relation between the theory of consciousness and psychoanalysis is also explored. Psychoanalysis is seen as compatible with the proposed theory, which is able to enlighten some aspects of the process of becoming conscious in psychoanalytic treatment. The general approach is interdisciplinary : the theory must take into account constraints derived from philosophy, neurophysiology, psychology, neuropsychology, etc. Consciousness is conceived, not as a property of some mental states, but as a specific higher-order activity, based on lower-order nonconscious activities. (shrink)

Se resaltan algunas peculiaridades sobre la manera como la Asociación Médica Mundial enfoca ciertos temas, ya que sus declaraciones y resoluciones reflejan cambios más o menos apreciables, que son manifiestos en los contenidos de ellas y orientan sus políticas. Se hace un comentario comparativo de las versiones de la Declaración de Ginebra de 1948 y 2017 con el Juramento hipocrático teniendo en cuenta las siguientes categorías: Carácter de la declaración; Tiempo verbal; Extensión en apotegmas o sentencias; núcleo epistémico; omisiones; innovaciones; (...) tipo de ethos. Las facultades de Medicina deberían incluir en sus currículos los acentos y contenidos convenientes para que el ethos hipocrático se conserve y la profesión médica pueda seguir gozando de la confianza, el respeto y el honor, que solo se mancillan cuando en la práctica profesional se cede terreno por intereses autónomos y economicistas. Como alternativa orientadora a las declaraciones de Ginebra se sugiere la versión creada por el Value of Life Committee, Inc. (shrink)

RESUMEN Se exploran las relaciones entre hegemonía y filosofía de la praxis en A. Gramsci. Se examina la influencia de la filosofía hegeliana sobre estas nociones en los Cuadernos de la cárcel. Asimismo, se estudia la crítica a estas nociones a la luz del feminismo de la diferencia y del debate sobre hegemonía, universalidad y contingencia iniciado por E. Laclau, J. Butler y S. Žižek. Se concluye que concebir la hegemonía desde la perspectiva de la filosofía de la praxis significa (...) que la acción político-intelectual, según Gramsci, no solo implica la formación de una hegemonía alternativa, sino una crítica políticamente operante a la pretensión de universalidad del discurso hegemónico a partir de la exposición de su contingencia histórica. ABSTRACT The paper explores the relations between hegemony and the philosophy of praxis in A. Gramsci, and examines the influence of Hegelian philosophy on these notions as set forth in the Prison Notebooks. Likewise, it studies the critique of these notions from the perspective of difference feminism and of the debate over hegemony, universality, and contingency initiated by E. Laclau, J. Butler, and S. Žižek. The conclusion is that conceiving hegemony from the perspective of the philosophy of praxis means that, according to Gramsci, political-intellectual action implies not only the formation of an alternative hegemony, but also a politically operative critique of the claim to universality of hegemonic discourse, on the basis of the unveiling of its historical contingency. (shrink)

En los procesos de identificación social muchas veces la valoración del pasado resulta fundamental. La existencia objetiva de esa valoración ha propiciado que distintos actores sociales, en diferentes momentos históricos, hayan hecho uso del pasado en la estructuración de las ideologías que sustentan los procesos de identificación y, en consecuencia, sus propios proyectos políticos. Es decir, los mitos políticos están compuestos manifiestamente de dos componentes básicos. Por un lado, consisten en la así llamada política simbólica y por el otro lado, (...) son parte de la memoria colectiva. Es por esto que los mitos se enfrentan con las bases mismas del proyecto de modernidad, quizás la razón por la cual sea la politología la disciplina de las ciencias sociales que menos los ha estudiado. La utopía andina, el mahdi o el doceavo imán, el emperador alemán oculto y dormido y el bolivarianismo, constituyen algunos estos mitos políticos. (shrink)

Research has indicated that microRNAs (miRNAs), a special class of non-coding RNAs (ncRNAs), can perform important roles in different biological and pathological processes. miRNAs’ functions are realized by regulating their respective target genes (targets). It is thus critical to identify and analyze miRNA-target interactions for a better understanding and delineation of miRNAs’ functions. However, conventional knowledge discovery and acquisition methods have many limitations. Fortunately, semantic technologies that are based on domain ontologies can render great assistance in this regard. In our (...) previous investigations, we developed a miRNA domain-specific application ontology, Ontology for MIcroRNA Target (OMIT), to provide the community with common data elements and data exchange standards in the miRNA research. This paper describes (1) our continuing efforts in the OMIT ontology development and (2) the application of the OMIT to enable a semantic approach for knowledge capture of miRNA-target interactions. (shrink)

In recent years, sequencing technologies have enabled the identification of a wide range of non-coding RNAs (ncRNAs). Unfortunately, annotation and integration of ncRNA data has lagged behind their identification. Given the large quantity of information being obtained in this area, there emerges an urgent need to integrate what is being discovered by a broad range of relevant communities. To this end, the Non-Coding RNA Ontology (NCRO) is being developed to provide a systematically structured and precisely defined controlled vocabulary for the (...) domain of ncRNAs, thereby facilitating the discovery, curation, analysis, exchange, and reasoning of data about structures of ncRNAs, their molecular and cellular functions, and their impacts upon phenotypes. The goal of NCRO is to serve as a common resource for annotations of diverse research in a way that will significantly enhance integrative and comparative analysis of the myriad resources currently housed in disparate sources. It is our belief that the NCRO ontology can perform an important role in the comprehensive unification of ncRNA biology and, indeed, fill a critical gap in both the Open Biological and Biomedical Ontologies (OBO) Library and the National Center for Biomedical Ontology (NCBO) BioPortal. Our initial focus is on the ontological representation of small regulatory ncRNAs, which we see as the first step in providing a resource for the annotation of data about all forms of ncRNAs. (shrink)

The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the “semantic glue” to provide a common understanding of data (...) from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. (shrink)

Resenha crítica à Fundamentação da Metafísica dos Costumes de Immanuel Kant.

La noticia de la conclusión del primer pangenoma humano ocurre veinte años después de que se pudo contar con una versión de referencia de la información genética completa de la especie humana. Las limitaciones técnicas de ese tiempo permitieron que esa versión tuviera errores y varias lagunas de la información genética. Ahora es posible contar con un nuevo atlas gigante con información que permite evidenciar la gran diversidad genética de la especie humana. Este trabajo está siendo realizado por el Consorcio (...) Internacional de Referencia del Pangenoma Humano, del que hacen parte cerca de cien investigadores y está financiado por el Instituto Nacional de Investigación del Genoma Humano y por los Institutos Nacionales de Salud de EEUU. En este escrito que describe a grandes rasgos en qué consiste el proyecto, cuáles son sus aplicaciones posibles y las dificultades técnicas que tiene actualmente. Se repasan también algunos aspectos éticos y jurídicos y se dan pautas para su culminación: profundizar en la reflexión ética de los problemas que se generan; cuidar la formación en ética de la investigación, bioética e integridad científica en todos los actores del proceso; no perder de vista la Declaración Universal sobre el genoma humano y los derechos humanos de la UNESCO; orientar los desarrollos de la bioinformática, para que los datos obtenidos se manejen de una mejor manera; extremar la prudencia en el manejo de esos datos; revisar y reajustar las prioridades que se tienen en la investigación de estas temáticas. (shrink)

Justo antes de la pandemia por COVID-19, la Organización Mundial de la Salud definió unas prioridades de trabajo para la década 2020-2030. Un grupo interdisciplinario de profesionales de la salud reflexiona sobre estas prioridades, determinando unas categorías de análisis y, desde una perspectiva bioética, analiza cada una de ellas, ve su pertinencia, algunos eventos causales, las implicaciones que pueden tener si no son enfrentadas adecuadamente y hace sugerencias sobre la forma de llevarlas a cabo. En esta primera entrega se analiza (...) el primer grupo de prioridades estratégicas: “poblaciones más sanas”. En las conclusiones se destaca la conveniencia de acometer cada una de ellas de una manera colaborativa, gubernamental y privada; de reestructurar el sector salud con base en estas prioridades, aprovechando la experiencia obtenida en la lucha contra el COVID-19. La relación del ser humano con el medio ambiente también debe cambiar, apelando a la responsabilidad humana por el cuidado del planeta. (shrink)

La maternidad subrogada es una respuesta técnica ante una dificultad biológica que se puede dar en la reproducción humana. Luego de una introducción, que muestra la problemática que la guerra en Ucrania ha ocasionado en esta materia, se exponen algunas generalidades sobre la maternidad subrogada, su presencia en el mundo y sus costos; así mismo, se reflexiona sobre los problemas éticos, bioéticos y biojurídicos desde las perspectivas biológica, antropológica y jurídica en cada uno de los actores del proceso (madre sustituta, (...) pareja o persona contratante, el embrión resultante y la sociedad). Se concluye que la maternidad subrogada, aunque sea técnicamente posible, no es una solución ética ni bioética para la esterilidad humana porque deja de lado el respeto a la dignidad; es un negocio que incluye explotación de mujeres; impone actuaciones jurídicas que fuerzan la realidad al declarar como derechos lo que no son más que deseos y es causa de varias formas de vulnerabilidad en las personas que intervienen en ella y en la sociedad en su conjunto. (shrink)

O presente artigo tem por objetivo analisar a produção cinematográfica "Medianeras – Buenos Aires na era do amor virtual" sob a perspectiva do conceito de Reificação de György Lukács, problematizando transversalmente os protestos urbanos do início do século XXI e a vida urbana na contemporaneidade. Em seguida irá problematizar o uso de filmes no ensino de Filosofia, sua pertinência enquanto ferramenta de ensinoaprendizagem e o sentido da transversalidade como campo de atuação do ensino de Filosofia no Ensino Médio a partir (...) da Lei de Diretrizes de Base nº 9394/96. (shrink)

The ontological determination of the movement in its quality of way of Being incessantly moves the critic affirmed to denial it through come to be which affirms new critics, unity of continuities and discontinuities with the previous critic. Therefore, it is important to unveil the material determinations in which are rooted the conception of Being dissociated from Non-being consolidated in insurmountable distinction between Being and Entity in its quality of expression of ideas in an inverted reality, falsely apprehended. Ideally reproduced (...) reality that, nevertheless, allows alternatives corresponding to the realization of aims targeted to satisfy historically determined necessities. The confrontations in the production and reproduction of purposes to guide social relations cross-dress debility of determined and impotent movement to impose determinations to the full virtuosity of immobility that moves the transitory. The difference between Being e Entity conforms in a formal logic deprived from/of contradiction to affirm the development of knowledge in what, in truth, hindered and limit it to remain, reducing the movement to stationary, to what moves to what moves without moving, to what isolate the knowledge of reality, to what detaches idea and material, to what conserves and incarcerates and not to what transform and set free. The treatment conceived as a movement from radical critic brings together the ontological primacy to underpin the root of the constitution of social existence to establish the ontological determinations of the existence to consciousness is stated in Marx – being reaffirmed in Lukács – by affirming that categories are forms of Being, determinations from/of existence. The category of totality, as a result of it, constitute expression of form of Being from reality in movement and synthesis from multiples and mutual determinations of negated diversities in an unitarity which affirm them. Therefore, the dialectical reflexive movement refuses as an ineliminable condition to the movement which affirms to mould identity with unitarity between identity and non-identity or don’t conceive relation of identity with dialectic, with the existence of reality to express a contradiction and incessant transmutation between Being and Non-being. The totality by transmuting itself while remain totality albeit not identical to the previous moment embraces a category to synthesize the unity of diversity. This diversity moved and moving from/by unity contemplates the relation of identity ratio (nowadays totality) between the identity (continuity with the preceding totality) and the non-identity (discontinuity with the preceding totality). To ignore the identity of identity with a non-identity conforms the impotence of category to constitute an expression of existence for not affording the contradiction immanent to the existence of reality moving from transport incessant of Being to come to be which puts itself from Non-being to Being. In short, concomitantly the being is transposed to Non-being to a Being come to be transpose from Non-being to a Being whilst ontological determination is constituted and constitutive of movement. The realization of critic conditioned the self-critic that ontologically determines the denial of self-preservation because it constitutes roots in social conditions that limit the intended transformation through critic. The critique of science as an ideological and material condition of reproduction and realization of capital is not effective with the auto-conservation of Geography for conforming the necessity of conservation of science to be rooted in the conception of distinction idealized by superiority that would affirm the permanence and nullity of transcending the limitations to denial the inhumanity of alienation concomitantly affirm the conditions to recognition of necessities and possibilities oriented to an emancipatory purposes. The progressive compressing of expenditure of time on production and productivity of results in various fields of scientific knowledge – which do not realize strictly in the extent of knowledge or it would be equivalent to affirm the fallacy of isolation and to deny the material and historical determinations that constitutes the quality of form of Being -, expressed in the quality of objective necessity and possibility concomitantly to fragment the form and content of the orientation of aims for investigation and for apprehension of reality. The convergence of the movements above-mentioned conforms the constitution of consensus positivity of complexifying of knowledge, delimitating the conceiving of reality and the supposed objective determinations a priori that constraint the conscious apprehension of necessities and of purposes that manifestate in the immediacy by the quality of developing individual and humankind potentialities of social being. Therefore, the conception of suprahistorical and insuppressible ontological determination depriving from social intentionalities in naturalize the impute of greater speed and complexity with lesser time and size of fragmented reality to be known, strengthening the conditions of inversion of reality. Reversed reality deforms the conscious apprehension of corresponding reduce the humanity of individual and gender social sphere of Being for alienating the necessities and goals of theory and practice, consciously aimed to the development of conditions for impoverishment humanity cross-dress in fallaciously things provided by humanity. Things that would had identity with men humanization obfuscating the unifying the developing of thing in the developing of men in the quality of thing, to conceive the most primary theoretical and practical necessity for the purpose of development of thing as an irrevocable necessity from human activity. The confrontation in the sphere of ideas constitutes itself while conceiving the real and, in this direction, the domination of necessities and purposes of material (re)production of society requires the domination of the categories of space and time as forms of Being of substance in motion. The detachment between Being and Entity conceives the indetermination of the dominant conception of reality that determines the conditions for the reproduction of life and the come to be of individuals and humankind. (shrink)

The rationality of the human being applied in science-technique in the contemporary capitalist system is distorted; the purpose, which is the good life for human beings, has become the means to sustain and feedback the technicist system of technological capitalism. Thus, the modus operandi of science, aims only to legitimize technology, apart from the ethics applied in this relationship between technology and human beings, and cut off from critical philosophical thinking. With the result presented, the problem lies in the reason (...) of the contemporary human being, who seeks to satisfy his desires and envisions the good life (eudaimonía) in material goods, suppressing the contemplative leisure of life (ataraxia); becoming a slave to the system it fosters. The objective is to demonstrate the need to reformulate the modern system, in order to earn a good life for human beings as a purpose of technical science, which should be the means for this and as technological advances in favor of the quality of human beings. and, not for capitalist reproduction. The research methodology is an exploratory bibliography, exposing and dialoguing with authors on the subject in order to forge our conclusion, that pleads for science-technical that enjoys ethics and human reason in favor of eudaimonia. (shrink)

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to (...) explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed. (shrink)

En 1968 ocurrieron dos hechos sobre los cuales cabe hacer una reflexión orientada por la bioética: la llamada Revolución del 68 y la aparición de la Carta encíclica Humanae Vitae. El Concilio Vaticano II, que fue presentado como una actualización de la Iglesia católica al mundo moderno, fue el escenario de los estudios previos a la redacción del documento pontificio, donde Pablo VI dejó clara la postura del Magisterio de la Iglesia sobre la moral sexual y anticipa los errores prácticos (...) que se seguirían a planteamientos conceptuales antropológicos erróneos o equivocados sobre esa temática. Hay necesidad de rehabilitar la Humanae vitae para volver a percibir el acto conyugal en su “verdad inalterable”, donde no se puede separar el bien y la belleza de la donación mutua de los cónyuges, que redunda en el bien común de la sociedad para defender su célula básica y nuclear que es la familia. In 1968, two events occurred on which it is worth reflecting on bioethics: the so-called Revolution of 1968 and the appearance of the Encyclical Letter Humanae Vitae. The Second Vatican Council, which was presented as an update of the Catholic Church to the modern world, was the scene of the studies prior to the drafting of the pontifical document, where Paul VI made clear the position of the Magisterium of the Church on sexual morality and it anticipates the practical errors that would follow erroneous or mistaken anthropological conceptual approaches on this subject. There is a need to rehabilitate Humanae vitae in order to re-perceive the conjugal act in its "unalterable truth", where good and beauty cannot be separated from the mutual donation of the spouses, which results in the common good of society to defend its basic and nuclear cell which is the family. (shrink)

El objetivo tradicional de la unidad de cuidados intensivos (UCI) es disminuir la mortalidad y morbilidad de los pacientes en estado crítico. A pesar de los avances médicos y tecnológicos, la UCI continúa siendo un lugar común en donde la muerte ocurre, por lo que en la actualidad el equipo de salud de la UCI debe estar familiarizado con los cuidados paliativos y su legislación en México. Preservar la dignidad del paciente, evitar el daño y mantener una comunicación adecuada entre (...) los miembros del equipo de salud y los familiares es fundamental. No existe una técnica única y universal aceptada para la atención de los pacientes en estado terminal en las UCI, por lo que se debe individualizar cada caso y definir objetivos de atención junto con el paciente o sus familiares dentro del marco legal vigente en México. (shrink)

This study's focus was to determine students' English competency level after exposure to video lessons as supplemental materials. The respondents of the study were 139 Grade 9 students of Mahaplag National High School coming from four sections enrolled for School Year 2022-2023. Quasi-experimental method of research particularly the pretest-posttest design was utilized in the study. Frequency counts, mean percentage score, weighted mean, standard deviation, and paired samples T-test were utilized in data analysis. Results of the study revealed that the competency (...) level of the students on all three learning competencies before the exposure to video lessons is in the poor category. On the other hand, it was revealed in the study that after exposure to video lessons and through the administered post-test, students’ competency levels improved, which now belongs to the fair category. As to the student’s acceptance level of video lessons as supplemental materials, it was found that students positively accept video lessons as supplemental materials for selected English 9 competencies. It was also ascertained that there was a statistically significant increase in the scores of the students on all three competencies after exposure to video lessons. Furthermore, there was a significant increase in students' overall scores on the three competencies. From the results of the study, it can be concluded that video lessons can be a great supplemental material in teaching English 9 competencies. (shrink)

Colombia es el país donde por primera vez se legisló sobre eutanasia en América Latina y el Caribe, en el sentido de despenalizar o legalizar su práctica. La novedad del caso colombiano está en la vía jurídica mediante la cual se despenalizó el “homicidio por piedad”, denominación tipificada en el Código Penal para la eutanasia. Como se explicará en el capítulo correspondiente, la eutanasia en Colombia se despenaliza mediante una sentencia de la Corte Constitucional, máximo organismo del poder judicial del (...) país, sin pasar antes por el Congreso de la República (rama legislativa). Este artilugio jurídico fue el mismo que se utilizó en los EUA, en la década del setenta del siglo pasado, para hacer ver el aborto como si fuera un derecho derivado de la Constitución (caso Roe vs. Wade), que sin embargo fue corregido por la misma Corte Suprema de ese país en 2022. En la sentencia Dows vs. Jackson se indica que el aborto no es un derecho constitucional y que los organismos judiciales no son competentes para regular sobre esa materia y sobre otras análogas. Una de ellas es la eutanasia. Luego de una introducción donde se expone parte de la historia de la eutanasia, se pasa a la terminología relacionada con ella. Algunos argumentos a favor de la eutanasia son examinados para mostrar lo que hay detrás de cada uno y concluir por qué su práctica no es una buena idea. En la parte central del libro se hace una reflexión sobre la valoración ética que se puede hacer del acto eutanásico. Posteriormente se ofrecen unas reflexiones sobre la cultura de la muerte, pero sobre todo del sentido que el sufrimiento puede tener para el ser humano. Antes de las conclusiones el lector encontrará dos ensayos sobre la eutanasia en el mundo y en Colombia, que procuran aportar datos para una mejor comprensión de la situación. En el último capítulo se incluye un estudio breve sobre lo que dicen las religiones de la eutanasia. Las conclusiones se aprovechan para mostrar cómo la medicina paliativa y los cuidados paliativos son el mejor recurso médico que hace innecesario el que alguien pueda plantearse la aplicación de la eutanasia. Además, se explica qué son las voluntades anticipadas y la objeción de conciencia. -/- . (shrink)

El pensamiento de Agustín de la Riega es, en esencia, revolucionario. No sólo porque a partir de él ha de de-construirse el primer fundamento de la filosofía fenomenológica, sino también porque abre el pensar filosófico a un plano de realidad efectiva (o, siguiendo a Agustín Basave Fernández del Valle, de habencia), que es en verdad una vida… más allá de las dicotomías modernas: objeto/sujeto, inmanencia/trascendencia, ser/ente, etc. La dimensión del haber -con estatuto trans-ontológico- es análogo al plano de fuerzas de (...) Deleuze. Pero lo que en verdad hace a De la Riega martillar la esfera de Pascal, es justamente la tarea liberadora de la filosofía que ha de desencadenar al hombre del destino instrumentalista de la reducción categorial, la diferencia ontológica y el sentido del mundo, construido -desde Jonia hasta Friburgo- por los filósofos de la pura unidad identitaria que someten lo humano al yugo del Ser-Fuerza Oculta y de la deuda ontológica. El pensamiento de De la Riega apela a descentrar la vida del carácter fundacional de la razón como esencializadora o fuente de derecho del ser, invocando al haber en tanto dimensión que acaece por fuera de todo intento de reducción técnico-racional. Descentrar el ser orientándolo hacia la radical diferencia de lo vivo no es un acto propio de la conciencia intencional que especula sobre los aspectos constitutivos del haber, sino que es eminentemente una vivencia de lo fáctico en tanto abierto al estar ahí nomás, ambiguo, plurimórfico y contingente Dicha apertureidad de lo habiente es la que pone a De la Riega en diálogo, y creemos que es esa la misma metodología por medio de la cual descubrir su pensamiento, hasta nuestros días inadvertido, especialmente por las ya obsoletas escuelas académicas de comentaristas fenomenólogos, para quienes es dificultoso salir-se más allá del círculo, y por quienes la filosofía toda ha devenido en una nota al pie de las obras de Heidegger, Merleau-Ponty o Husserl, proscribiendo la posibilidad de un pensar creador y radical. (shrink)

A book with all the abstracts of the talks held in the conference "La Escuela de Salamanca y su proyección iberoamericana": University San Dámaso (Madrid), 13th-15th October 2021.

The sixteenth century witnessed a major intellectual event: the birth of modernity. This book presents the School of Salamanca as the "first version of modernity", a modernity developed with a peculiarly Hispanic stamp. The Salamancans confronted the problems of a singular historical moment, in which Spain was playing a leading role in the encounter between Europe and America. The thinkers of Salamanca tackled crucial issues such as the right to property, economic ethics, freedom and slavery, the justice of war... In (...) the matrix of the Salamanca university, international law and the elements of reflection that would provide arguments for the abolition of slavery were born. This book brings together scholars from different geographical areas: several authors from Latin America, as well as from different European countries, sign their contributions. These diverse origins reflect the rich universality of the Hispanic project that had its heart in the reflections of the School of Salamanca. The diversity of topics addressed, ranging from the more practical questions of trade and the freedom of the American Indians to the subtleties of metaphysics or theology, is a good example of the richness of the issues addressed by those intellectuals who initiated modernity. (shrink)