It is crucial for engineers to anticipate the socio-ethical impacts of emerging technologies. Such acts of anticipation are thoroughly normative and should be cultivated in engineering ethics education. In this paper we ask: ‘ how do we anticipate the socio-ethical implications of emerging technologies responsibly? ’ And ‘ how can such responsible anticipation be taught? ’ We o ff er a conceptual answer, building upon the framework of Responsible Innovation and its four core practices: anticipation, reflexivity, inclusion, and responsiveness. We (...) forge a more explicit link between the practices of anticipation, reflexivity, and inclusion, while also enriching them with insights from disability studies, STS, design theory, and philosophy. On this basis we present responsible anticipation as an activity of reflective problem framing grounded in epistemic humility. Via the RI-practice of responsiveness we present responsible anticipation as a creative approach to engineering ethics, offering engineering students a critical yet productive perspective on how ethics may inform innovation. (shrink)

The guiding premise of this chapter is that we, as teachers in higher education, must consider how the content and form of our teaching can foster inclusivity through a responsiveness to neurodiverse learning styles. A narrow pedagogical focus on lectures, textual engagement, and essay-writing threatens to exclude neurodivergent students whose ways of learning and making sense of the world may not be best supported through these traditional forms of pedagogy. As we discuss in this chapter, we, as engineering ethics (...) educators, designed and implemented a new engineering ethics exercise with which we aimed to promote inclusivity at the levels of form and content. At the content level, students were invited to critically engage with inclusivity-undermining ableist assumptions in technology development. This took shape, at the form level, through a hands-on ‘material tinkering’ workshop in which students collaboratively and creatively altered (or ‘hacked’) artifacts used in contexts of disability and healthcare, so as to operationalize values of inclusivity and accessibility. Our hunch was that this hands-on tinkering workshop would simultaneously encourage a meaningful way of engagement with these ethical issues and values, while also enacting a more inclusive learning environment by enriching the range of pedagogical activities and learning formats available to our students.As we aim to show in this chapter, we believe this hunch largely panned out – though there are clear areas for future improvement pertaining to the pilot exercise itself and the research we conducted on the exercise. We begin by offering a description of our tinkering exercise. We discuss the exercise’s source of inspiration (Sect. 16.2.1) and its implementation (Sect. 16.2.2), which is visually captured via photographic documentation. We then discuss (Sect. 16.3) how we utilized a triangulated research method to assess the pedagogical value of the exercise. After we discuss our findings, we conclude by identifying areas for future improvement (Sect. 16.4). (shrink)

The guiding premise of this chapter is that we, as teachers in higher education, must consider how the content and form of our teaching can foster inclusivity through a responsiveness to neurodiverse learning styles. A narrow pedagogical focus on lectures, textual engagement, and essay-writing threatens to exclude neurodivergent students whose ways of learning and making sense of the world may not be best supported through these traditional forms of pedagogy. As we discuss in this chapter, we, as engineering ethics (...) educators, designed and implemented a new engineering ethics exercise with which we aimed to promote inclusivity at the levels of form and content. At the content level, students were invited to critically engage with inclusivity-undermining ableist assumptions in technology development. This took shape, at the formal level, through a hands-on ‘material tinkering’ workshop in which students collaboratively and creatively altered (or ‘hacked’) artifacts used in contexts of disability and healthcare, so as to operationalize values of inclusivity and accessibility. Our hunch was that this hands-on tinkering workshop would simultaneously encourage a meaningful way of engagement with these ethical issues and values, while also enacting a more inclusive learning environment by enriching the range of pedagogical activities and learning formats available to our students. As we aim to show in this chapter, we believe this hunch largely panned out - though there are clear areas for future improvement pertaining to the pilot exercise itself and the research we conducted on the exercise. We begin by offering a description of our tinkering exercise. We discuss the exercise’s source of inspiration (2.1) and its implementation (2.2), which is visually captured via photographic documentation. We then discuss (3) how we utilized a triangulated research method to assess the pedagogical value of the exercise. After we discuss our findings, we conclude by identifying areas for future improvement (4). (shrink)

This paper provides a retrospective and prospective overview of TU Delft’s approach to engineering ethics education. For over twenty years, the Ethics and Philosophy of Technology Section at TU Delft has been at the forefront of engineering ethics education, offering education to a wide range of engineering and design students. The approach developed at TU Delft is deeply informed by the research of the Section, which is centered around Responsible Research and Innovation, Design for Values, and Risk Ethics. These theoretical (...) approaches are premised on the notion that technologies are inherently value-laden, and as such contain the possibility of fostering or hindering moral values. Each of these approaches encourages students to take a proactive attitude with respect to their projects and profession, thinking creatively about – and taking responsibility for – how to both prevent harm and do good via the technologies they help develop. To explain how this is put into practice, this paper sketches a brief history of ethics teaching at TU Delft, outlines current activities, and presents future plans for Bachelor and Master’s level engineering ethics education at TU Delft. (shrink)

Responsible innovation (RI), also termed Responsible Research and Innovation, has emerged due to increasing concern over how to integrate ethical and societal values into research and innovation policy and governance (Von Schomberg 2013), in response to questioning of the societal role of science as well as populist resurgence in some countries (Long and Blok 2017a). Within a RI approach, innovators must consider three dimensions of responsibility, including the dimensions of (1) ‘avoiding harm’ to people and the planet, (2) ‘doing good’ (...) through the offering of innovations that foster sustainable development, and (3) the development of facilitative global governance schemes (Voegtlin and Scherer 2017). (shrink)

Responsible innovation (RI), also termed Responsible Research and Innovation, has emerged due to increasing concern over how to integrate ethical and societal values into research and innovation policy and governance (Von Schomberg 2013), in response to questioning of the societal role of science as well as populist resurgence in some countries (Long and Blok 2017a). Within a RI approach, innovators must consider three dimensions of responsibility, including the dimensions of (1) ‘avoiding harm’ to people and the planet, (2) ‘doing good’ (...) through the offering of innovations that foster sustainable development, and (3) the development of facilitative global governance schemes (Voegtlin and Scherer 2017). (shrink)

Abstract: Artificial Intelligence (AI) is revolutionizing organizational dynamics by reshaping both structures and processes. This paper explores how AI-driven innovations are transforming organizational frameworks, from hierarchical adjustments to decentralized decision-making models. It examines the impact of AI on various processes, including workflow automation, data analysis, and enhanced decision support systems. Through case studies and empirical research, the paper highlights the benefits of AI in improving efficiency, driving innovation, and fostering agility within organizations. Additionally, it addresses the challenges associated with AI (...) integration, such as resistance to change, ethical concerns, and data security issues. The paper concludes by offering insights into future trends and implications for organizations navigating the evolving landscape of AI-driven change. (shrink)

This paper critically examines Japan's approach toward the adoption of Generative AI such as ChatGPT in education via studying media discourse and guidelines at both the national as well as local levels. It highlights the lack of consideration for socio-cultural characteristics inherent in the Japanese educational systems, such as the notion of self, teachers’ work ethics, community-centric activities for the successful adoption of the technology. We reveal ChatGPT’s infusion is likely to further accelerate the shift away from traditional notion of (...) self, which has been ongoing during past educational reforms, towards active and self-directed learning. The current discourse on Generative AI’s infusion in education is driven by neoliberal agendas aimed at increasing employability and individualism. Moreover, the introduction of ChatGPT in the context of Japan's educator culture offers potential solutions to address issues of overwork but also necessitates considerations regarding increased responsibilities for teachers and the preservation of their central role in student education. Finally, the irreplicable social growth fostered by community-centric activities in the Japanese educational system highlights the limitations of ChatGPT in replicating dynamic social interactions, emphasizing the importance of holistic approaches to education beyond technological integration. (shrink)

The world of entrepreneurship has historically been linked with taking risks and the potential for significant rewards. However, there persists a notable gender imbalance in the entrepreneurial landscape, wherein women entrepreneurs remain a minority. Women navigating the entrepreneurial path encounter distinct challenges, setting their experiences apart from their male counterparts. In Balayan, Batangas, despite strides towards gender equality, women entrepreneurs continue to face challenges in the entrepreneurial landscape. This qualitative study delves into the experiences of 10 successful female entrepreneurs who (...) met specific criteria. Accordingly, semi-structured interviews are conducted, exploring various aspects of participants' experiences and revealing their motivations, achievements, challenges, and strategies. Thematic analysis reveals the connection between familial, community-driven, and personal motivations that drive these entrepreneurs forward. Despite facing obstacles such as financial constraints and gender biases, they prioritize financial gains and personal growth. With resilience, innovation, and dedication, these women overcome challenges and achieve success, utilizing support networks and online marketing strategies to their advantage. Recommendations include empowering women in entrepreneurship, strengthening support networks, introducing tailored financial literacy programs, and advocating against gender biases. Implement skill development initiatives and provide specialized education in online marketing. Engage in policy advocacy, celebrate success stories, and continuously research challenges and successes. Foster collaborative partnerships between businesses, educational institutions, and communities, and advocate for increased funding opportunities for sustainable growth. This research emphasizes the strength and capabilities of women entrepreneurs in Balayan, Batangas, affirming that "pink doesn't mean weak.". (shrink)

Can political sovereignty still be theoretically and practically useful in tackling climate change in a socially fair way? The global nature of climate change unequivocally demands a high degree of international coordination. Traditionally viewed as an impediment to effective climate action, sovereignty has been criticised for fostering nationalistic and isolationist tendencies that obstruct global environmental cooperation. This paper challenges the prevailing “sovereignty-as-enemy” thesis and argues for a nuanced reappraisal of sovereignty as a potentially valuable asset in addressing the climate crisis. (...) This paper posits that sovereignty can be a critical tool for promoting decisive and equitable climate policies by examining its historical and theoretical underpinnings and complex relationship with neoliberal globalisation. The argument is rooted in a multidisciplinary literature comprising critiques of the neoliberal economy and globalisation model, the erosion of states’ sovereign prerogatives, critiques of neoliberal environmentalism, the interaction between trade and climate regimes, and the intellectual history of sovereignty. The public-private dichotomy is identified as a significant feature of sovereignty in times of climate change. Keywords:sovereignty, climate politics, neoliberal globalisation, public-private divide. (shrink)

Universal Basic Income (UBI) has been proposed as a potential way in which welfare states could be made more responsive to the ever-shifting evolutionary challenges of institutional adaptation in a dynamic environment. It has been proposed as a tool of “real freedom” (Van Parijs) and as a tool of making the welfare state more efficient. (Friedman) From the point of view of complexity theory and evolutionary economics, I argue that only a welfare state model that is “polycentrically” (Polanyi, Hayek) organized (...) as an evolving network of distributed decision-making can respond to the challenges of complexity in an adaptively efficient manner. UBI has the theoretical possibility to facilitate flexible, bottom-up innovation, since a) it embodies the “rule of law” principles of generality, nondiscrimination, simplicity, and transparency, and b) it grants people widespread freedom to experiment, innovate, and deviate from established practices and norms; but whether it can be made to work as intended depends on a number of variables in its design. I situate my research in the contemporary UBI debate around automation and technological development, which I interpret creatively through the lens of contemporary evolutionary political economy. I advance a syncretic model of institutional design based upon the shared insights of the Santa Fe, Neo-Hayekian, and Neo-Schumpeterian schools of evolutionary economics that, following Adam Thierer and Michael Munger, I call the framework of Permissionless Innovation (PI). Under the PI framework, which is a development of the tradition of evolutionary liberalism (Hume, Smith, Mandeville, Mill, Hayek, Polanyi, Schumpeter, Hodgson), individuals are granted the default right to innovate without having to ask for permission, and the right to basic income, which they can use to support their right to innovate, mutate, and experiment. This framework is a liberal framework to the extent it relies on widespread human freedom as a means of fostering innovation and social learning. And it is an evolutionary framework to the extent that it seeks to facilitate evolutionary socioeconomic processes for the sake of social progress and welfare advancement. I proceed to show, through an analysis of how innovation operates in both the economy and the cultural domain, that UBI can be used as an important cornerstone of an evolutionary liberal model of “ecostructural” governance that treats the socioeconomic order as an ecological garden of spontaneous growths, adaptations, and innovations. I call this the Permissionless Innovation Universal Basic Income (PIUBI) framework. In it, the right to innovate, deviate, and mutate is upheld as the “gold standard” of institutional design whereby individuals are granted widespread freedoms combined with the provision of UBI and other innovation-fostering (carefully bound) services and regulations. In the coming decades, UBI may even enable poor people to take better advantage of Human Enhancement Technologies (HETs) and other experimental innovations. Such a framework is compatible with a fast pace of evolutionary development, but the regulatory model accompanying such a framework must be capable of responding to evolutionary lock-ins, maladaptive innovations, self-destructive behaviour on the part of UBI recipients, and the management of catastrophic and existential risks. In the end, I will have shown that the PIUBI framework can be justified as a plausible default institutional mechanism for responding to radical uncertainty, but it needs to be experimentally adapted to changing circumstances with the help of various situation-specific, polycentric, multi-level, approaches. (shrink)

The case for an unprecedented penetration of life mechanisms into the politics of Western modernity has been a cornerstone of 20th-century social theory. Working with and beyond Foucault, this article challenges established views about the history of biopower by focusing on ancient medical writings and practices of corporeal permeability. Through an analysis of three Roman institutions: a) bathing; b) urban architecture; and c) the military, it shows that technologies aimed at fostering and regulating life did exist in classical antiquity at (...) the population scale. The article highlights zones of indistinction between natural and political processes, zoē and bíos, that are not captured by a view of destructive incorporation of or over life by sovereign power. In conclusion, the article discusses the theoretical potential of this historical evidence for contemporary debates on ‘affirmative biopolitics’ and ‘environmental biopower’. (shrink)

East Asia’s economy is leading the world into the new Asian century. While meritocratic practices in the educational and private sectors are often considered pivotal conditions for East Asia’s economic success, experts have pointed out that the path ahead requires new approaches to ensure social cohesion and stability, which depend on the quality of relations across social divides. These considerations raise multiple questions for philosophers: What forms of social meritocracy are necessary to sustain social cohesion? Moreover, how can the detrimental (...) effects of meritocratic practices be contained? Is it possible to utilise some of the intellectual resources indigenous to East Asia to generate innovative solutions? This paper argues that the answers to these questions lie in the indigenous Confucian conceptual resources. Confucian ideas can inspire a more desirable societal ideal for the future of East Asia. In particular, the Confucian emphasis on cultivating reciprocal harmonious human relationships and others’ morality can guide new approaches to fostering social cohesion. As Confucian personal cultivation through harmonious relations is a process of social cohesion, these ideas inspire a) a multiple approach to policymaking that is not only grounded in economic redistribution, b) a richer understanding of societal progress, and c) a democratic approach to fostering social cohesion. Unlike Confucian meritocrats and scholars who defend the Confucian roots of East Asian forms of political and social meritocracy, this paper proves that Confucian conceptual resources can help formulate a societal vision that strengthens cohesion and mitigates the adverse effects of meritocratic practices. (shrink)

I defend two collapsing or reductionist arguments against Weak Pro-Natalism (WPN), the view that procreation is generally merely permissible. In particular, I argue that WPN collapses into Strong Pro-Natalism (SPN), the view that procreation is generally obligatory. Because SPN conflicts with the dominant view that procreation is never obligatory, demonstrating that WPN collapses into or entails SPN establishes epistemic parity (at least as concerns reproductive liberty) between WPN and Anti-Natalism (AN), the view that procreation is always impermissible. First, I distinguish (...) between two moral goods: the good of procreation itself and the good of procreative potential. Second, I contend that the average moral agent is obligated to assist needy children via adoption, fostering, or other financial or interpersonal support. Third, I present the first collapsing argument: If an agent’s justification for not assisting needy children is preservation of their resources (financial or interpersonal) for their actual future offspring, that justification is preserved only if they eventually and actually procreate. Thus, their eventual procreation is morally obligatory, and SPN follows. Fourth, I present the second collapsing argument, which assumes procreative potential as the relevant good: If an agent’s justification for not assisting needy children is preservation of their resources for their potential future offspring, that justification holds only if (a) the objective or subjective valuation of the opportunity is of the relevant type and valence to justify not assisting needy children and (b) the agent sincerely values the opportunity. Fifth, I argue that (a) is unsatisfied and that while (b) is satisfied in most cases, it entails that most agents are obligated to desire or be behaviorally disposed to pursue procreation for themselves (i.e., SPN). Thus, I conclude that both actual procreation and procreative potential are either insufficient justifications for not assisting needy children or that they entail obligatory pro-reproductive attitudes or behaviors. (shrink)

The present dissertation investigates certain facets of the logical structure of oughts – where “ought” is used as a noun, roughly meaning obligation. I do so by following two lines of inquiry. The first part of the thesis places oughts in the context of practical rationality. The second part of the thesis concerns the inference rules governing arguments about oughts, and specifically the inference rule of Reasoning by Cases. These two lines of inquiry, together, aim to expound upon oughts in (...) rationality and reasoning. The methodology used in this dissertation is the one of philosophical logic, in which logical, qualitative models are developed to support and foster conceptual analysis. The dissertation consists of four main chapters. The first two chapters are devoted to the role of oughts in practical rationality. I focus on the so-called Enkratic principle of rationality, which – in its most general formulation – requires that if an agent believes sincerely and with conviction that she ought to do X, then she intends to X. I develop a logical framework to investigate the (static and dynamic) relation between those oughts believed by the agent and her intentions. It is shown that, under certain minimal assumptions, the Enkratic principle of rationality is a principle of limited validity. The following two chapters of the dissertation constitute a study of the classical inference rule of Reasoning by Cases, which – in its simplest form – moves from the premises “A or B”, “if A then C” and “if B then C” to the conclusion “C”. Recent literature has called the validity of Reasoning by Cases into question, with the most influential counterexample being the so-called Miners’ Puzzle – an instance of Reasoning by Cases where “C” involves oughts. I provide a unifying explanation of why the Miners’ Puzzle emerges. It is shown that, within specific boundaries, Reasoning by Cases is a valid inference rule. (shrink)

The bi-polar confrontation between the Soviet Union and the USA involved many leading game theorists from both sides of the Iron Curtain: Oskar Morgenstern, John von Neumann, Michael Intriligator, John Nash, Thomas Schelling and Steven Brams from the United States and Nikolay Vorob’ev, Leon A. Petrosyan, Elena B. Yanovskaya and Olga N. Bondareva from the Soviet Union. The formalization of game theory (GT) took place prior to the Cold War but the geopolitical confrontation hastened and shaped its evolution. In our (...) article we outline four similarities and differences between Western GT and Soviet GT: 1) the Iron Curtain resulted in a lagged evolution of GT in the Soviet Union; 2) Soviet GT focused more on operations research and issues of centralized planning; 3) the contemporary Western view on Soviet GT was biased and Soviet contributions, including works on dynamic stability, non-emptiness of the core and many refinements, suggest that Soviet GT was able to catch up to the Western level relatively fast; 4) international conferences, including Vilnius, 1971, fostered interaction between Soviet game theorists and their Western colleagues. In general, we consider the Cold War to be a positive environment for GT in the West and in the Soviet Union. (shrink)

In this paper I borrow from Maria Lugones’ work on playful “world-traveling” and W.E.B. Du Bois’ notion of “double consciousness” to make the case that humor can facilitate an openness and cooperative attitude among an otherwise closed, even adversarial audience. I focus on what I call “subversive” humor, that which is employed by or on behalf of those who have been continually marginalized. When effectively used, such humor can foster the inclination and even desire to listen to others and, (...) if only for brief moments, adopt their point of view. To be able to see oneself as others see you can also be a desirable capacity, because along with such multidimensional seeing comes an epistemic advantage lacking in those who have no need nor desire to see as others do, especially if the vision of the others happens to be from below where one perceives that the promises of our explicit ideals are constantly being implicitly broken. Such humor is aesthetic, pleasurable in and of itself, and not amenable to scientific dissection. But it is also a skill that can be honed into a powerful tool of persuasion in circumstances where straightforward arguments are less effective. It can raise consciousness about the lived experiences of those suffering under systemic oppression and foster world travelling. Subversive humor encourages audiences, especially those who contribute to what Jean Harvey calls “civilized oppression”, to playfully travel across worlds and “tarry along” with the perspectives of the marginalized. (shrink)

It is commonly held that Kant, with his 1798 essay The Conflict of the Faculties, relinquishes some progressive stances and retreats to conservative positions. According to several interpreters, this is especially evident from Kant’s discussion of moral progress and public use of reason. Kant avers that moral progress can only occur through state-sanctioned education “from top to bottom” and entrusts the emergence of a state endowed with the relevant resolution and ability to “a wisdom from above” (7:92-93). According to numerous (...) interpreters, this call for state intervention and the accompanying surrender to a superhuman wisdom manifest Kant’s retreat from initially republican to later conservative positions. In Kant’s previous writings, the notion of public use of reason indicates the unrestricted freedom to communicate one’s thoughts, provided that the communication does not take place in the exercise of one’s function as a state official, and potentially encompasses all adult men. Instead, in The Conflict of the Faculties, Kant contrasts university professors’ freedom to make public use of their reason with the other public officials’ obligation “to uphold whatever […] the crown sanctions for them to expound publicly” (07:08). Thus, according to several scholars, Kant ends up disenfranchising the vast majority of people from the public use of reason and adjusting an emancipatory notion to the absolutist conception of speech and civil service. On my reading, with The Conflict of the Faculties, Kant neither retreats to conservative positions nor softens any progressive tenets of critical philosophy. On the contrary, I intend to show that a) the project of a state-sanctioned education constitutes Kant’s republican rebuttal of conservative positions on their ground, and is fully in keeping with critical philosophy; b) Kant sets forth a new notion of public use of reason that reverses the order of moral progress presented in his previous writings, but retains all its emancipatory character. I intend to support my interpretation by a) conducting a rhetorical analysis showing how Kant’s rhetoric aims to persuade the ruler that his interests are best served by fostering the regulative ideas of pure practical reason as discovered by critical philosophy; b) analysing Kant’s use of the term ‘public’ (both as the adjective ‘öffentlich’ and the noun ‘Publikum’) and showing how it retains its wide scope and emancipatory function and even expands them to areas previously subjected to legitimate censorship. (shrink)

Bai Tongdong’s Against Political Equality argues for Confucian meritocracy over a pure democracy of equals. His arguments draw on a multiple modernities comparison between the Spring and Autumn Warring States period in China and early modernity in the West, and rest on a Mencian conception of human nature according to which humans are equal in moral potential but not in moral actuality. I argue that there is a crucial disanalogy between this Chinese early modernity and Western early modernity: the role (...) of capitalism. In a similarly comparativist and modernist spirit, drawing on B. R. Ambedkar and M. K. Gandhi, I argue that this disanalogy challenges both Bai’s critique of democracy and his positive account. Bai’s failure to take into account the role of capitalism in Western modernity raises a challenge to the explanatory power of his Mencian conception of human nature with regard to the failings of contemporary democracies, namely that capitalism fosters the relevant features of our moral psychology that cause those failings. Further, without that grounding assumption, Bai’s arguments against democracy cut equally against his Confucian meritocracy. The disanalogy also creates challenges for his positive proposal. Bai, I argue, provides an ideal theory of Confucian meritocracy at the same time as he provides a non-ideal theory of democracy. But, taking into account the non-ideal cultural and moral psychological features of capitalism, Bai’s Confucian meritocracy is likely to fall into an unjust and oligarchic hierarchy. (shrink)

Numerous scholars, philosophers, and experts in aesthetics have underscored the profound significance of a life enriched by the presence of beauty. Consequently, the appreciation of aesthetic experiences is considered pivotal for achieving self-discovery and self-transcendence (Howell et al. 2017). Despite theoretical prominence, limited qualitative research has been conducted on this topic. To address this gap in research, this study’s objective emphasized two questions guiding the inquiry; What is the role of aesthetic encounters in aiding self-realization or individuation? and, how do (...) these experiences foster self-transcendence? -/- A thematic analysis was performed on the online interviews conducted (N=25), and their results revealed seven themes pertaining to self-realization: a) Losing Yourself to Find Yourself; b) Relatability and Self-Reflection in Art; c) Identity as a Collection of Skills; d) Art as a Medium for Self-Expression and Acknowledgment; e) Aesthetic Genres and Taste as Identity; f) Belonging and Social Identity through Art; and g) Personal Interests and Choices in Artistic Consumption. Furthermore, seven themes for the second research question of self-transcendence were also discovered: a) Mother Nature’s Beauty; b) Intense, Passionate, and Overwhelming Experiences of Heightened Consciousness; c) Sacred Symbolism, Archetypal Imagery, and the Collective Unconscious; d) Collective Effervescence, Social Connection, and Shared Meaning; e) The ‘Profound’ Found in the Mundane; f) Feelings of Spiritual Elevation and Wellbeing; and g) Self-Referential Meaning-Making through Art. These findings evidenced the transformative potential of aesthetic experiences, shedding light on the facets of personal growth and meaning that individuals derive from such encounters. (shrink)

RESUMO A inseminação artificial em tempo fixo (IATF) é uma das biotecnologias de reprodução mais estudadas dos últimos anos, e a busca pelo equilíbrio entre a fisiologia animal e o controle hormonal fomenta uma série de estudos. Sendo assim, o objetivo com este trabalho foi avaliar a eficiência da aplicação do hormônio liberador de gonadotrofinas (GnRH) no dia zero (D0) do protocolo de IATF, a base de estrógeno e progesterona sobre a taxa de penhez por IATF. O experimento foi desenvolvido (...) na Universidade Federal de Uberlândia (UFU), na Fazenda Experimental do Glória, localizada no município de Uberlândia, no estado de Minas Gerais. Foram avaliadas 69 inseminações de vacas leiteiras mestiças, divididas em dois grupos com diferentes protocolos; Controle: sem aplicação de GnRH e Tratamento: aplicação de GnRH no dia zero do protocolo. Todos os animais foram inseminados com sêmen previamente analisado. O diagnóstico de gestação foi realizado 32 dias após a inseminação, com aparelho de ultrassonografia equipado com probe linear transretal de 7,5 MHz. Os dados foram analisados por análise descritiva, sendo avaliado o efeito da relação protocolo e presença de corpo lúteo no início do protocolo e efeito da relação protocolo e ordem de IA Pós-Parto sobre a taxa de concepção. A taxa de concepção após a realização do Protocolo Tratamento foi de 53% (17/32) e do Protocolo Controle foi de 43% (16/37). Portanto, conclui-se que o protocolo de sincronização de vacas leiteiras mestiças com a aplicação de GnRH no dia zero do protocolo resultou em um aumento no número da taxa de concepção de vacas leiteiras mestiças. Palavras-chave: biotecnologia; bovinocultura; hormônio; ovulação; reprodução. ABSTRACT The artificial insemination at fixed time (AIFT) is one of the most studied reproduction biotechnologies in recent years, and the search for a balance between animal physiology and hormonal control fosters a series of studies. Therefore, the objective of this work was to to evaluate the efficiency of gonadotrofine hormone inducer (GnRH) on day zero (D0) of the AIFT protocol, an estrogen and progesterone base on an AIFT rate. The experiment was developed at the Federal University of Uberlândia (UFU), at the Experimental Farm of Glória, located in the municipality of Uberlândia, in the state of Minas Gerais. Were evaluated 69 inseminations of crossbred dairy cows divided into two groups with different protocols; Control: without application of GnRH and Treatment: application of GnRH on day zero of the protocol. All animals were inseminated with previously analyzed semen. The diagnosis of pregnancy was performed 32 days after insemination, with an ultrasound device equipped with a 7.5 MHz transrectal linear probe. The data were analyzed by descriptive analysis, evaluating the effect of the protocol relationship and the presence of corpus luteum at the beginning of the protocol and the effect of the protocol relationship and postpartum AI order on the conception rate. The conception rate after performing of the Treatment Protocol was 53% (17/32) and the Control Protocol was 43% (16/37). Therefore, it is concluded that the synchronization protocol of crossbred dairy cows with the application of GnRH on day zero of the protocol resulted in an increase in the number of conception rates of crossbred dairy cows. Keywords: biotechnology; cattle breeding; hormone; ovulation; reproduction. -/- REFERÊNCIAS BIBLIOGRÁFICAS ATANASOV, A. S.; DINEVA, J. D.; YOTOV, S. A. Ultrasonic evaluation of uterine involution in Bulgarian Murrah buffalo after administration of oxytocin. Animal Reproduction Science, v.133, p.71-76, 2012. BALL, P. J. H.; PETERS, A. R. Reprodução em bovinos. São Paulo – SP. BARBOSA, C. F. et al. Inseminação artificial em tempo fixo e diagnóstico precoce de gestação em vacas leiteiras mestiças. Revista Brasileira de Zootecnia, v. 40, p. 79-84, 2011. BARBOSA, C. F. et al. Inseminação artificial em tempo fixo e diagnóstico precoce de gestação em vacas leiteiras mestiças. Revista Brasileira de Zootecnia, Viçosa, MG, v. 40, n. 1, pág. 79-84, 2011. BARROS, C. M.; FIGUEIREDO, R. A.; PINHEIRO, O. L. Estro, ovulação e dinâmica folicular em zebuínos. Revista Brasileira de Reprodução Animal, Belo Horizonte, v.19, p. 9-22, 1995. BARUSELLI, P. S. Controle farmacológico do ciclo estral em ruminantes. Faculdade de Medicina Veterinária e Zootecnia. Departamento de reprodução animal, Universidade de São Paulo, 2000. BARUSELLI, P. S. et al. Review: Using artificial insemination v. natural service in beef herds. Animal, London, v. 12, p. 45-52, 2018. BEG, M. A.; GINTHER, O. J. Follicle selection in cattle and horses: role of intrafollicular factors. Reproduction, v. 132, pag. 365-377, 2006. BERTAN, C. M.; BINELLI, M.; MADUREIRA, E. H. Caracterização do estro de novilhas cruzadas (Bos taurus indicus x Bos taurus taurus) por radiotelemetria. Brazilian Journal of Veterinary Research and Animal Science, São Paulo, v. 43, n. 6, p. 816-823, 2006. BÓ, G. A.; BARUSELLI, P. S.; MARTINEZ, M. F. Pattern and manipulation of follicular development in Bos indicus cattle. Animal Reproduction Science, v.78, p.307-326, 2003. BÓ, G.; CUTAIA, P. S; BARUSELLI. Programas de inseminación artificial y transferencia de embriones a tiempo fijo. In: SIMPÓSIO INTERNACIONAL DE REPRODUÇÃO APLICADA, 1., 2004, Londrina [Trabalhos apresentados] Cornélio Procópio: Geraembryo, 2004. p. 56-81. Disponível em:. Acesso em: 12 nov. 2022. BORGES, A. M. et al. 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Parâmetros reprodutivos, metabólitos e produção de leite de vacas mestiças Holandês x Zebu submetidas a dois manejos pré-parto. Tese (Doutorado em Medicina Veterinária) - Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, 2009. CASTILHO, E. F. IATF como ferramenta no melhoramento genético de bovinos de leite. In: CASTILHO, E. F. (org.). Inseminação artificial em tempo fixo (IATF) em bovinos leiteiros. 1. ed. Maringá: IEPEC, 2015. p. 148-191. CHEBEL, R. C. et al. Factors affecting conception rate after artificial insemination and pregnancy loss in lactating dairy cows. Animal Reproduction Science, v.84, p.239-255, 2004. CLIMATE DATA ORG. Clima Uberlândia. Disponível em:. Acesso em: 08 fev. de 2022. Curso de Transferência de Embriões, Uberlândia: ASBIA, 2021. Disponível em:. Acesso em: 08 fev. 2022. DA SILVA, Emanuel Isaque Cordeiro. Endocrinologia da Reprodução Animal. 2020. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia Clínica do Ciclo Estral de Vacas Leiteiras: Desenvolvimento Folicular, Corpo Lúteo e Etapas do Estro. 2020. DA SILVA, Emanuel Isaque Cordeiro. Fisiologia da Reprodução de Bovinos Leiteiros: Aspectos Básicos e Clínicos. Emanuel Isaque Cordeiro da Silva, 2022. DA SILVA, Emanuel Isaque Cordeiro; DA SILVA, Emanuel Isaque. Hormônios e Sistema Endócrino na Reprodução Animal. 2020. D’AVILA, C. A. et al. Hormônio utilizados na indução da ovulação em bovinos. Revista Brasileira de Reprodução Animal. Belo Horizonte, v. 43, n. 4, p. 797-802, out./dez.2019. Disponível em:. Acesso em: 25 de jan. 2022. DEMÉTRIO, D.G.B. et al. Factors affecting conception rates following artificial insemination or embryo transfer in lactating Holstein cows. Journal of Dairy Science, v.90, p.5073-5082, 2007. DUARTE JUNIOR, M. F. et al. Aspectos relacionados a fisiologia do anestro pós parto em bovinos. Colloquium Agrariae, Cuiabá, v.9, p.43-71, 2013. DUKES, H. H.; SWENSON, M. J.; REECE, W. Dukes fisiologia dos animais domésticos. 12. ed. Rio de Janeiro: Guanabara Koogan, 2006. FERREIRA, A. M. Reprodução da fêmea bovina: fisiologia aplicada e problemas mais comuns (causas e tratamentos). Juiz de Fora: Edição do Autor, 2010. FINK, G. Gonadotropin secretion and its control. In: KNOBIL, E.; NEILL, J. (ed.), The physiology of reproduction. New York: Raven Press, 1988. p. 1349-1377. FOLMAN, Y. et al. Comparison of methods for the synchronization of estrous cycles in dairy cows. 2. Effects of progesterone and parity on conception. Journal of Dairy Science, v.73, p.2817-2825, 1990. FONSECA, F. A. et al. Reproductive traits of Holsteins and Jerseys. Effects of age, milk yield, and clinical abnormalities on involution of cervix and uterus, ovulation, estrous cycles, detection of estrus, conception rate, and days open. Journal of Dairy Science, v.66, p.1128- 1147, 1983. FORTUNE, J. E.; RIVERA, G. M.; YANG, M. Y. 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C., Uso do protocolo Crestar® em tratamentos utilizando benzoato de estradiol, PGF2α, PMSG e GnRH para controle do ciclo estral e ovulação em vacas de corte. 2002, 62f. Dissertação de Mestrado, Piracicaba, 2003. MOSES, V. S.; BERTONE, A. L. Nonsteroidal anti-inflammatory drugs. Veterinary Clinics of North America, v.18, p.21-37, 2002. NAKAMURA, T.; SAKAMOTO, K. Reactive oxygen species up-regulates cyclooxygenase2, p53, and Bax mRNA expression in bovine luteal cells. Biochemical and Biophysical Research Communications. v.284 p.203-210. 2001. NASSER, L. F. T. Resposta superovulatória na primeira onda de crescimento folicular em doadoras Nelore (Bos taurus indicus). 2006, 80f. Tese (Doutorado) - USP. FMVZ. Departamento de reprodução animal, São Paulo. OLIVEIRA, M. Fisiologia da reprodução bovina e métodos de controle do ciclo estral. 2006. 28 f. Tese (Especialização em Reprodução e Produção de Bovinos) -UNIVERSIDADE CASTELO BRANCO, Rio de Janeiro, 2006. PALHANO, H. B. Reprodução em Bovinos, LF livros de veterinária, 2 edição, 2008, 249p. PONCIO, V. A. P. EFICIÊNCIA DE DOIS PROTOCOLOS DE IATF UTILIZANDO BENZOATO DE ESTRADIOL OU GnRH. Nova Odessa. 2021. Disponível em:. Acesso em: 25 de jan. 2022. PURSLEY, J. R.; MEE, M. O.; WILTBANK, M. C. Synchronization of ovulation in dairy cows using PGF2α and GnRH. Theriogenology, v.44, p.915-923, 1995. REICHENBACH, H. D.; MORAES, J. C. F.; NEVES, J. P. 2008. Tecnologia do sêmen e inseminação artificial em bovinos. In: Gonçalves P. B. D.; Figueiredo J. R. e Freitas V. J. F. Biotécnicas aplicadas à reprodução animal. 2ª ed. São Paulo: Ed. Roca. 395 p. ROBINSON, R. S. et al. Corpus luteum-endometriumembryo interactions in the dairy cow: underlying mechanisms and clinical relevance. Reproduction in Domestic Animals, v.43, p.104-12, 2008. Roca, 3ª Edição, 232 p., 2006. RUAS, J. R. M. et al. Vacas F1 Holandês x Zebu: uma opção para sistema de produção de leite em condições tropicais. Inf. Agropec., v.35, p.113-120, 2014. SARTORI, R. Manejo reprodutivo da fêmea leiteira. Reprodução Animal, Belo Horizonte, v.31, n.2, p.153-159, abr./jun. 2007. Disponível em:. Acesso em: 08 fev. 2022. SILVA, A. T. N. et al. Efeito de diferentes estratégias de manejo na distribuição da prenhez em vacas de corte mestiças paridas. In: XVI Congresso Brasileiro de Reprodução Animal. (Goiânia, Brasil). Resumo 158, 2007. SILVA, A.S. et al. Avaliação do custo benefício da inseminação artificial convencional e em tempo fixo de fêmeas bovinas pluríparas de corte. Revista Brasileira de Reprodução Animal, v.31, n.4, p.443-445, 2007. SOUZA, A. H. et al. Efeitos da gonadotrofina coriônica equina e do tipo de estímulo ovulatório em um protocolo de IA cronometrada sobre as respostas reprodutivas em vacas leiteiras. Teriogenologia, Stoneham, v. 72, n. 1, pág. 10-21, 2009. STABENFELDT, G. H.; EDQVIST, L. E. Processos Reprodutivos da Fêmea. In: SWENSON, M. J.; REECE, W., Dukes Fisiologia dos Animais Domésticos, Rio de Janeiro: Guanabara Koogan, 1996. cap. 36, p. 615-644. VALLE, E. R. O ciclo estral de bovinos e métodos de controle. Campo Grande: EMBRAPA – CNPGC, 1991. 24p. (EMBRAPA-CNPGC. Documentos, 48). VISHWANATH, R. Artificial insemination: the state of the art. Theriogenology, v.59, p.571- 584, 2003. WOLFENSON, D. et al. The effect of a GnRH analogue on the dynamics of follicular development and synchronization of estrus in lactating cyclic dairy cows. Theriogenology, v.42, p.633- 644, 1994. YAMADA, K. Desenvolvimento da sincronização da ovulação e inseminação artificial em tempo fixo em vacas leiteiras. Jornal de Reprodução e Desenvolvimento, Nagoya, v. 51, n. 2, pág. 177-186, 2005. (shrink)

A quarter of a century ago, the first systematic behavioral experiments were performed to clarify the nature of color constancy—the effect whereby the perceived color of a surface remains constant despite changes in the spectrum of the illumination. At about the same time, new models of color constancy appeared, along with physiological data on cortical mechanisms and photographic colorimetric measurements of natural scenes. Since then, as this review shows, there have been many advances. The theoretical requirements for constancy have been (...) better delineated and the range of experimental techniques has been greatly expanded; novel invariant properties of images and a variety of neural mechanisms have been identified; and increasing recognition has been given to the relevance of natural surfaces and scenes as laboratory stimuli. Even so, there remain many theoretical and experimental challenges, not least to develop an account of color constancy that goes beyond deterministic and relatively simple laboratory stimuli and instead deals with the intrinsically variable nature of surfaces and illuminations present in the natural world. (shrink)

In a now classic paper published in 1991, Alberch introduced the concept of genotype–phenotype (G!P) mapping to provide a framework for a more sophisticated discussion of the integration between genetics and developmental biology that was then available. The advent of evo-devo first and of the genomic era later would seem to have superseded talk of transitions in phenotypic space and the like, central to Alberch’s approach. On the contrary, this paper shows that recent empirical and theoretical advances have only sharpened (...) the need for a different conceptual treat- ment of how phenotypes are produced. Old-fashioned metaphors like genetic blueprint and genetic programme are not only woefully inadequate but positively misleading about the nature of G!P, and are being replaced by an algorithmic approach emerging from the study of a variety of actual G!P maps. These include RNA folding, protein function and the study of evolvable soft- ware. Some generalities are emerging from these disparate fields of analysis, and I suggest that the concept of ‘developmental encoding’ (as opposed to the classical one of genetic encoding) provides a promising computational–theoretical underpinning to coherently integrate ideas on evolvability, modularity and robustness and foster a fruitful framing of the G!P mapping problem. (shrink)

We argue that stereotypes associated with concepts like he-said–she-said, conspiracy theory, sexual harassment, and those expressed by paradigmatic slurs provide “normative inference tickets”: conceptual permissions to automatic, largely unreflective normative conclusions. These “mental shortcuts” are underwritten by associated stereotypes. Because stereotypes admit of exceptions, normative inference tickets are highly flexible and productive, but also liable to create serious epistemic and moral harms. Epistemically, many are unreliable, yielding false beliefs which resist counterexample; morally, many perpetuate bigotry and oppression. Still, some normative (...) inference tickets, like some activated by sexual harassment, constitute genuine moral and hermeneutical advances. For example, our framework helps explain Miranda Fricker’s notion of “hermeneutical lacunae”: what early victims of “sexual harassment” — as well as their harassers — lacked before the term was coined was a communal normative inference ticket — one that could take us, collectively, from “this is happening” to “this is wrong.”. (shrink)

For a stable visual world, the colours of objects should appear the same under different lights. This property of colour constancy has been assumed to be fundamental to vision, and many experimental attempts have been made to quantify it. I contend here, however, that the usual methods of measurement are either too coarse or concentrate not on colour constancy itself, but on other, complementary aspects of scene perception. Whether colour constancy exists other than in nominal terms remains unclear.

Slurs have been standardly assumed to bear a very direct, very distinctive semantic relationship to what philosophers have called “neutral counterpart” terms. I argue that this is mistaken: the general relationship between paradigmatic slurs and their “neutral counterparts” should be assumed to be the same one that obtains between ‘chick flick’ and ‘romantic comedy’, as well a huge number of other more prosaic pairs of derogatory and “less derogatory” expressions. The most plausible general relationship between these latter expressions — and (...) thus, I argue, between paradigmatic slurs and “neutral counterpart” terms — is one of overlap in presumed extension, grounded in overlap in associated stereotypes. The resulting framework has the advantages of being simple, unified, and, unlike its orthodox rivals, neatly accommodating of a much wider range of data than has previously been considered. More importantly, it positions us to better understand, identify, and confront the insidious mechanisms of ordinary bigotry. (shrink)

The immense outpouring of archaeological discoveries this past century has shed new light on ancient East Asia, and China in particular. Yet in concert with this development another, more troubling, trend has likewise gained momentum: the looting of cultural heritage and the sale of unprovenienced antiquities. Scholars face difficult questions, from the ethics of working with objects of unknown provenance, to the methodological problems inherent in their research. The goal of this Element is to encourage scholars to critically examine their (...) relationships to their sources and reflect upon the impact of their research. The three essays in this Element present a range of disciplinary perspectives, focusing on systemic issues and the nuances of method versus ethics, with a case study of the so-called 'Han board' MSS given as a specific illustration. This title is also available as open access on Cambridge Core. (shrink)

Multinational companies commonly and increasingly undertake their research in low and middle-income countries through commercial clinical research organizations (CROs). The involvement of these scientific middle men complicates the application of the theories of justice. We examine those complexities, and conclude that while the difficulties are not immune to analysis in terms of these theories, the theories have to be deployed in new ways in order to be useful in the new commercial world.

International trade enables countries to expand their markets, access more products, improve resource allocation, and boost economic growth by leveraging comparative advantage and specialization. The aim of this article is to analyze the primary factors that influence Malawi’s international trade flows. The study is relevant because it examines Malawi’s trade patterns with its main partners, which include surrounding nations and traditional trade allies. The novelty is that, through the analysis, the research offers valuable insights into the primary factors that influence (...) Malawi’s international commerce. Panel data is gathered from various sources, including the International Monetary Fund (IMF) and World Bank, covering the period from 2000 to 2023 for 11 countries that are trading partners with Malawi. We employ the Bayesian Mindsponge gravity methodology. The results show that the economic size (characterized by the gross domestic product) of the origin and destination countries, bilateral agreements, and the population size of the destination country have a beneficial impact on Malawi’s exports. In conclusion, Malawi’s export performance is significantly enhanced by the economic size of both Malawi and its trading partners, the existence of bilateral agreements, and the population size of the destination countries, underscoring the importance of strategic economic partnerships and targeted trade policies in boosting Malawi’s international trade. We recommend Malawi authorities focus on strengthening bilateral agreements and targeting trade relationships with larger and more populous economies to boost international trade. (shrink)

While many aspects of cognition have been shown to be shared between humans and non-human animals, there remains controversy regarding whether the capacity to mentally time travel is a uniquely human one. In this paper, we argue that there are four ways of representing when some event happened: four kinds of temporal representation. Distinguishing these four kinds of temporal representation has five benefits. First, it puts us in a position to determine the particular benefits these distinct temporal representations afford an (...) organism. Second, it provides the conceptual resources to foster a discussion about which of these representations is necessary for an organism to count as having the capacity to mentally time travel. Third, it enables us to distinguish stricter from more liberal views of mental time travel that differ regarding which kind(s) of temporal representation is taken to be necessary for mental time travel. Fourth, it allows us to determine the benefits of taking a stricter or more liberal view of mental time travel. Finally, it ensures that disagreement about whether some species can mentally time travel is not merely the product of unrecognised disagreement about which temporal representation is necessary for mental time travel. We argue for a more liberal view, on the grounds that it allows us to view mental time travel as an evolutionarily continuous phenomenon, and to recognise that differences in the ways that organisms mentally time travel might reflect different temporal representations, or combinations thereof, that they employ. Our ultimate aim, however, is to create the conceptual framework for further discussion regarding what sorts of temporal representations are required for mental time travel. (shrink)

This paper explores the notion of the self as one of the main obstacles in advancing neuroscience. Some folks argue for strict naturalism in order to study the brain objectively. However, in this process of naturalization, we run the risk of losing key components that make up our experience as human beings, namely emotions, ideas, and values. Therefore, I argue for moderate naturalism in an attempt to reconcile with the self. I reference Immanuel Kant’s moral law theory in order to (...) discuss the ethical implications of following a moderate naturalist view of the self in advancing neuroscience. (shrink)

Anh chàng Anhinga, còn gọi là chim cổ rắn, xuất trong hai bức tranh tiêu đề “Nóng” ngày 20/11/2023. Một năm sau, lại tìm được ngôi nhà mát mẻ hơn cho anh chàng. Chốn đó là xứ sở kỳ quặc, lắm chuyện kỳ khôi, nơi cư trú của ông Bói Cá, gọi là Xóm Chim. Chứ ở mãi trong Gallery mãi cũng chán.

Small changes in daylight in the environment can produce large changes in reflected light, even over short intervals of time. Do these changes limit the visual recognition of surfaces by their colour? To address this question, information-theoretic methods were used to estimate computationally the maximum number of surfaces in a sample that can be identified as the same after an interval. Scene data were taken from successive hyperspectral radiance images. With no illumination change, the average number of surfaces distinguishable by (...) colour was of the order of 10,000. But with an illumination change, the average number still identifiable declined rapidly with change duration. In one condition, the number after two minutes was around 600, after 10 min around 200, and after an hour around 70. These limits on identification are much lower than with spectral changes in daylight. No recoding of the colour signal is likely to recover surface identity lost in this uncertain environment. (shrink)

Đáp án không phải Blanche-Neige. Thực tế, ở nước ta cũng không có tuyết. Đúng ra là quá hiếm. Giữa núi rừng miền Bắc rét mướt ngày mùa đông, ruộng ngô trổ cờ xung quanh hoa hậu ruộng.

The design argument has taken on different formulations among Muslim thinkers. Arguably, most of these approaches might be described as Paleyan. In this chapter, however, I seek to develop a non-Paleyan approach toward design discourse by focusing on the thought of the Muslim theologian, Ibn Taymiyya (d. 1328 CE). In developing a Taymiyyan model of design-based theistic belief, I argue that this model can resist some of the problems associated with Paleyan approaches. Specifically, it avoids concerns over the soundness or (...) cogency of the Paleyan inference amid Darwinian objections. I argue that this is because on the Taymiyyan model, design-based theistic beliefs are noninferential and concern the ultimate or metaphysical cause of the design in nature, such that they do not rival naturalistic scientific explanations of biological phenomena. Despite three noteworthy objections to the model, I suggest that it offers a plausible way to defend design-based theistic belief. (shrink)

Wherever philosophers disagree, one of the things at issue is likely to be what they disagree about, itself. In addition to asking whether moral realism is true, and which forms of moral realism are more likely to be true than others, we can also ask what it would mean for some form of moral realism to be true. The usual aspiration of such inquiry is to find definitions that all can agree on, so that we can use terms in a (...) uniform way. But we doubt that this aspiration is always possible, or even desirable. It will be our goal in this chapter to sketch out some of our reasons for such skepticism, and to lay out a picture of what philosophical inquiry can look like in metaethics and beyond, even when it is impossible to reach uniform agreement on the terms of the debate. (shrink)

In the Third Antinomy of the Critique of Pure Reason (1781) [Kritik der reinen Vernunft], Immanuel Kant (1724-1804) associates freedom with infinity. According to the definition given in this book, only an infinite being not subject to causality can be defined as free. However, the fact that a finite being, such as a human, is always subject to the laws of nature implies that they are perpetually bound by causality, which hinders their freedom. Freedom devoid of causality cannot be theoretically (...) justified. Another reason for this is Kant’s assertion in the Second Analogy of Critique of Pure Reason, where he states that everything in the phenomenal world is subject to causality. Accordingly, freedom can be conceived not in the phenomenal world but only in the noumenal world. In the First Critique, freedom, defined as a cause without a cause, a cause without being the result of another cause, later be characterized as negative freedom in the third section of the Groundwork of the Metaphysics of Morals (1785) [Grundlegung zur Metaphysik der Sitten]. Such conceptualization of freedom cannot be determined by any other cause than itself. While there may be a theoretical foundation for accepting such a cause as uncaused, we have moral reasons to believe in it. This moral foundation in question guides us toward the notion of positive freedom. Here, unlike negative freedom, we are subject to moral laws, and as long as we comply with these, we can experience freedom as a finite being. This is because adhering to the laws we set for ourselves enables us to be morally the cause of our own actions. Thus, Kant renders freedom through positive freedom. Following this line of argument, negative freedom appears meaningful to us only within the framework of positive freedom. Jean-Luc Nancy (1940-2021) finds a problematic Kantian account of freedom as an uncaused cause in his book The Experience of Freedom (1988) [L’expérience de la liberté]. Because, according to this perspective, humans are not only subject to the laws of nature but also to moral cause-and-effect relationships with others, they exist at the ix limit of freedom. By this means, considering freedom as a duty imposed on the subject leads to ambiguous analyses such as negative/positive freedom in Kantian philosophyーIn post-Kantian philosophy, the ambiguity persists until Friedrich Wilhelm Joseph Schelling (1775-1854)1 , who finds the solution by negating freedom. Therefore, according to Nancy, freedom should be considered not as a Kantian Idea but through its relationship with human finitude and experience. Thus, through the criticism directed at Kant in Martin Heidegger’s (1889-1976) Kant and the Problem of Metaphysics (1929) [Kant und das Problem der Metaphysik], Nancy attempts to resolve the confusion created by the concept of freedom, which despite being associated with infinity in Kant, is made possible in the practical world through respect for the moral law. In this direction, Nancy finds the solution in the freedom that becomes conceptually elusive, transforming it into an act that goes beyond being a mere duty and which permeates all our experiences. In this book, Nancy introduces the initial stages of “community” and “singularity” concepts, which he would later develop further. For this, he begins the book's introductory section by emphasizing Martin Heidegger’s statement in §9 of Being and Time (1927) [Sein und Zeit], where “freedom” is mentioned as another name for existence. As a justification, he refers to the concept of Da-sein [being-there] and states that every being [être] is a being-in-common [être-en-commun], and freedom should be thought of through this. Namely, the problem of freedom is approached not as a political or ethical issue but as an ontological matter. Within the framework of beingin-common, this situation transforms into an ontological “generosity [générosité ontologique].” -/- 1 Philosophical Investigations into the Essence of Human Freedom [Philosophische Untersuchungen über das Wesen der menschlichen Freiheit und die damit zusammenhängenden Gegenstände], Schelling, approaches freedom not through infinity but rather through finitude. While Heidegger and Nancy pursue different paths, they both adhere to the idea of finitude freedom in Schelling. x Despite primarily emphasizing Heidegger’s thought in writing this text as his aggrégation thesis, Jean-Luc Nancy desires to transcend it and maintain a certain distance. This transcendence and distancing include authors from the French Phenomenological tradition, such as Georges Bataille (1897-1962), Maurice Blanchot (1907-2003), and Jean-François Lyotard (1924-1998), and also incorporate the emphasis from Hannah Arendt (1906-1975) that death cannot be thought of independently of life. Referencing many philosophers from the continental philosophy tradition and developing a thematic reading through freedom, this bookーlike Nancy’s other worksーseeks ways to experience philosophy and thought freely in this own writing experience. So much so that this book, unlike Nancy’s other works like The Inoperative Community (1986) [La communauté désoeuvrée] ve Being Singular Plural (1996) [Être Singulier Pluriel], which is not widely discussed in secondary sources, is challenging to follow. Therefore, in examining this book as my Master’s research thesis and addressing the idea of freedom in Nancy, I found it appropriate to adopt a close reading method. Certainly, this research should not be considered independent of works such as The Discourse of Syncope (1976) [Le discours de la syncope], The Categorical Imperative (1983) [L’impératif catégorique], as they serve as examples of while engaging in philosophy, how Nancy refers and relates to the works within the philosophical tradition. (shrink)

This paper explores the events surrounding a string of robberies from the homes of young celebrities living in Los Angeles County by a group of teenagers referred to by the media as “The Bling Ring.” It argues that the group demonstrates the intersections of desire and materiality under the conditions of a culture driven by idolization of the celebrity, referring to the works of Jean Baudrillard, Pierre Bourdieu, and French collective Tiqqun. It further examines the events as a moment where (...) subjects were able to escape the life-narratives imposed upon them by the State. Rather than adhering to the norms of regular adolescent life, reproduced and enforced through what Michael Shapiro identifies as “national-time,” members of the Bling Ring endeavored to create their own lives according to what I refer to as “celebrity-time,” revealing processes of becoming in the work of Gilles Deleuze, and plasticity in that of Catherine Malabou. (shrink)

In lieu of an abstract, see the following excerpt: -/- Though his work has until now gone untranslated and been largely ignored in English scholarship, the historian of philosophy François Châtelet played a major role in the development of French thought that is on par with that of his more well-known contemporaries. Born in 1925, Châtelet was founding member of the University of Vincennes, Paris VIII’s experimental department of philosophy alongside Michel Foucault in the aftermath of the 1968 student protests. (...) In 1983, he would establish the Collège Internationale de Philosophie in Paris along with other prominent philosophers, an institution that in Alessandra Campana’s words, is at “the forefront of militant and engaged critical thinking,” in which it has sought to “relocate philosophy at the intersection of science, politics, psychoanalysis, art and literature, jurisprudence, and economy.” Châtelet’s association with radical educational institutions and the interdisciplinarity of research undertaken at the latter both point to what can be understood to be the essence of his philosophical project: that the history of philosophy is also a politics of philosophy. La Grèce Classique, La Raison, L’État, which was first published in 1978 and appears here in translation for the first time under the title Classical Greece, Reason, and the State, is exemplary in this regard, providing a powerful critique of the history of philosophy and its purported Greek origins. As Deleuze argues, Châtelet reveals that “Athens was not the advent of an eternal reason, but the singular event of a provisional rationalisation. In this view, the essence of classical philosophy cannot be extended to the contemporary era—neither in its original form, or in a revised form that has been modified and updated across the passage of time. Therefore, by politicising philosophy and its history, Châtelet’s work also shows philosophy to be indicative of a particular cultural moment, rather than as an the state, philosophy, and the tyranny of the logos · isolated discipline cut off from the influences of material life. He establishes a form of ‘rational empiricism’ for conducting a history of political philosophy that rejects universality for potentiality. Said otherwise, his work is indicative of what might be called the poststructuralist critique of historical narrative surrounding the canon of western thought, a critique that Michael Hardt rightfully argues “has problematised the foundations of philosophical and political thought.” However, Châtelet has made important contributions to the poststructuralist approach to theorising the western tradition that remain novel and insightful to a contemporary audience, rather than simply being one of many to problematise philosophy’s purported foundations. (shrink)

An ontology of geographic kinds is designed to yield a better understanding of the structure of the geographic world, and to support the development of geographic information systems that are conceptually sound. This paper first demonstrates that geographical objects and kinds are not just larger versions of the everyday objects and kinds previously studied in cognitive science. Geographic objects are not merely located in space, as are the manipulable objects of table-top space. Rather, they are tied intrinsically to space, and (...) this means that their spatial boundaries are in many cases the most salient features for categorization. The ontology presented here will accordingly be based on topology (the theory of boundary, contact and separation) and on mereology (the theory of extended wholes and parts). Geographic reality comprehends mesoscopic entities, many of which are best viewed as shadows cast onto the spatial plane by human reasoning and language. Because of this, geographic categories are much more likely to show cultural differences in category definitions than are the manipulable objects of table-top space. (shrink)

The APA has recently taken steps to address concerns related to teaching and supporting philosophers and students who come from less privileged backgrounds. I want to add to this project by fleshing out some concrete ways that philosophy professors contribute to the challenges faced by first-generation and financially disadvantaged philosophers and students. I hope that in making these behaviors explicit, it may be easier for faculty to acknowledge and overcome them.

RESUMO Os cuidados para atender às necessidades específicas da fêmea gestante são indispensáveis para o sucesso no manejo reprodutivo de qualquer espécie. Entretanto, é necessário entender que podem acontecer problemas em qualquer uma das fases reprodutivas, inclusive na gestação. Antes de tudo, na clínica e na produção, a sobrevivência dos fetos significa êxito no manejo reprodutivo. Durante o período gestacional podem se desenvolver diversas afecções no útero da fêmea, dentre elas podem ser citadas: mumificação fetal, gravidez ectópica, maceração fetal, prenhez (...) múltipla patológica e diversas anomalias que podem acometer os envoltórios e líquidos fetais. Essas doenças representam prognóstico ruim para a fêmea e para o feto, podendo resultar em perdas fetais. O conhecimento acerca das características dessas afecções, bem como a fisiopatologia e diagnóstico são indispensáveis para o sucesso da reprodução animal. Palavras-chave: Ginecologia, reprodução, gestação. ABSTRACT Care to meet the specific needs of pregnant females is essential for the successful reproductive management of any species. However, it is necessary to understand that problems may occur in any of the reproductive stages, including pregnancy. First of all, in the clinic and production, the survival of fetuses means success in reproductive management. During the gestational period, several pathological conditions can develop in the female uterus, among them fetal mummification, ectopic pregnancy, fetal maceration, pathological multiple pregnancy, and the various anomalies that can affect fetal envelopes and fluids. These illnesses represent a poor prognosis for the female and the fetus and may result in fetal loss. Knowledge about the characteristics of these conditions, as well as the pathophysiology and diagnosis are essential for the success of animal reproduction. Keywords: Gynecology, reproduction, gestation. -/- INTRODUÇÃO Na fisiologia da reprodução nos mamíferos, a implantação e a placentação são processos essenciais na nutrição do embrião e do feto e do seu desenvolvimento. Nos bovinos leiteiros, estima-se uma taxa de fertilização de 95%, com apenas 55% desses zigotos se desenvolvendo a termo e com perda de gestações de 35% (SILVA, 2021). Em equinos varia entre 5 e 15% (BRINSKO et al., 2011) e em suínos chega a 40% (VAN DER LENDE et al., 1994). A reprodução permite a manutenção do equilíbrio biótico, entretanto, falhas podem ocorrer, desde a concepção até o parto, incapacitando o pleno desenvolvimento gestacional e acarretando danos à cadeia produtiva (BRAGA e BARROSO, 2014). A taxa de perda gestacional atinge o pico durante o desenvolvimento embrionário e diminui após 45 dias, à medida que a gestação progride e a placentação ativa está completa (REESE et al., 2020). A placenta permite contato vascular eficaz entre as membranas fetais e o endométrio materno, através do qual ocorre a troca de oxigênio e de nutrientes vindos pelo sangue materno, além dos produtos de excreção do sangue fetal. Ela apresenta quatro membranas: a) âmnio, que contém o fluido amniótico que banha o embrião; b) saco vitelínico, que armazena os nutrientes; c) saco alantoide, onde os restos do metabolismo embrionário são estocados e d) córion, que delimita os limites do embrião e interage seletivamente com o ambiente externo, permitindo nutrientes e/ou oxigênio cheguem ao embrião (SILVA, 2020). No aparelho reprodutivo feminino as estruturas internas são presas pelo ligamento mesovário, que sustenta o ovário; o mesossalpinge, que ancora o oviduto e o mesométrio, que mantém o útero no seu lugar. Ele compreende os ovários, tubas, útero, cérvix, vagina, vestíbulo e vulva (KÖNIG e LIEBICH, 2021). O útero é formado por dois cornos, na região mesogástrica, que formam o corpo uterino, dorsal a vesícula urinária e ventral ao cólon descendente (PINTO e LORIGADOS, 2015). A cérvix fica na região caudal do útero (DYCE, 2019) e é composta pelo óstio uterino interno e o externo (KÖNIG e LIEBICH, 2021). O líquido amniótico é um complexo biológico que proporciona proteção mecânica, nutrientes e substâncias para o crescimento fetal e possui efeito antimicrobiano (UNDERWOOD et al., 2005). Ele desempenha várias funções: protege o feto contra traumas, desidratação e mudanças de temperatura; permite o desenvolvimento fetal e sua mobilidade; amplia a lubrificação da vagina após a ruptura da bolsa, inibe o crescimento bacteriano por ação mecânica de limpeza e previne aderências (GRUNERT e BIRGEL, 1984). As enfermidades do trato reprodutivo têm causado problemas reprodutivos, acarretando perdas econômicas (JÚNIOR et al., 2009). Os problemas na esfera da fisiopatologia da reprodução em animais, está associada ao período do periparto (SCOTT, 2005). Entretanto, existem relatos de sua ocorrência em fêmeas não gestantes e também fora do período puerperal (PRESTES et al., 2008; SALES et al., 2011). Devido à importância das diversas patologias que atingem o útero gravídico, esse trabalho tem como objetivo buscar identificar na literatura científica existente as características, diagnóstico e tratamento de cada alteração uterina, pautando discussão crítica sobre os processos de formação de cada uma. (shrink)

The acquisition of a new skill usually proceeds through five stages, from novice to expert, with a sixth stage of mastery available for highly motivated performers. In this chapter, we re-state the six stages of the Dreyfus Skill Model, paying new attention to the transitions and interrelations between them. While discussing the fifth stage, expertise, we unpack the claim that, “when things are proceeding normally, experts don’t solve problems and don’t make decisions; they do what normally works” (Dreyfus & Dreyfus, (...) 1988, pp. 30 – 31). This leads us to offer an account of the “perspectival deliberation” that arises for experts and masters and that is distinct from the calculative deliberation characteristic of the lower stages of skillfulness. (shrink)

According to Heidegger's Being and Time, social relations are constitutive of the core features of human agency. On this view, which I call a ‘strong conception’ of sociality, the core features of human agency cannot obtain in an individual subject independently of social relations to others. I explain the strong conception of sociality captured by Heidegger's underdeveloped notion of ‘being-with’ by reconstructing Heidegger's critique of the ‘weak conception’ of sociality characteristic of Kant's theory of agency. According to a weak conception, (...) sociality is a mere aggregation of individual subjects and the core features of human agency are built into each individual mind. The weak conception of sociality remains today widely taken for granted. I show that Christine Korsgaard, one of the most creative contemporary appropriators of Kant, operates with a weak conception of sociality and that this produces a problematic explanatory deficiency in her view: she is unable to explain the peculiar motivational efficacy of shared social norms. Heidegger's view is tailor made to explain this phenomenon. I end by sketching how Heidegger provides a social explanation of a major systematic concern animating Korsgaard, the concern with the importance of individual autonomy and answerability in human life. (shrink)

The New Evil Demon problem has been hotly debated since the case was introduced in the early 1980’s (e.g. Lehrer and Cohen 1983; Cohen 1984), and there seems to be recent increased interest in the topic. In a forthcoming collection of papers on the New Evil Demon problem (Dutant and Dorsch, forthcoming), at least two of the papers, both by prominent epistemologists, attempt to resist the problem by appealing to the distinction between justification and excuses. My primary aim here is (...) to critically evaluate this new excuse maneuver as a response to the New Evil Demon problem. -/- Their response attempts to give us reason to reject the idea that victims of the New Evil Demon have justification for believing as they do. I shall argue that this approach is ultimately unsuccessful, however much of value can be learned from these attempts. In particular, progress in the debate can be made by following those who advance the excuse maneuver and make explicit the connection between epistemic justification and epistemic norms. By doing so, the questions being debated are clarified, as is the methodology being used to attempt to answer them. (shrink)

If knowledge requires safety, then one might think that when the epistemic source of knowledge is testimony, that testimony must itself be safe. Otherwise, will not the lack of safety transfer from testimony to hearer, such that hearer will lack knowledge? Resisting this natural line of reasoning, Goldberg (2005; 2007) argues that testimonial knowledge through unsafe testimony is possible on the basis of two cases. Lackey (2008) and Pelling (2013) criticize Goldberg’s examples. But Pelling goes on to provide his own (...) example that attempts to show that Goldberg’s thesis is true: one can gain safe testimonial belief from unsafe testimony. If any of these counterexamples were correct, they would undermine the main reason to think that knowledge based on unsafe testimony is impossible. My aim in this paper is to critically assess these arguments, and to consider the possibility of knowledge through unsafe testimony. Drawing a general moral from the analysis of these cases, I shall contend that it is impossible to acquire safe belief solely on the basis of unsafe testimony. If so, then testimonial knowledge based solely on unsafe testimony is impossible. (shrink)

Advocates of dynamic systems have suggested that higher mental processes are based on continuous representations. In order to evaluate this claim, we first define the concept of representation, and rigorously distinguish between discrete representations and continuous representations. We also explore two important bases of representational content. Then, we present seven arguments that discrete representations are necessary for any system that must discriminate between two or more states. It follows that higher mental processes require discrete representations. We also argue that discrete (...) representations are more influenced by conceptual role than continuous representations. We end by arguing that the presence of discrete representations in cognitive systems entails that computationalism (i.e., the view that the mind is a computational device) is true, and that cognitive science should embrace representational pluralism. (shrink)

In the wake of the advent of genome editing technology CRISPR-Cas9 (clustered regularly interspaced palindromic repeat (CRISPR)-associated protein 9), there has been a global debate around the implications of manipulating the human genome. While CRISPR-based germline gene editing is new, the debate about the ethics of gene editing is not – for several decades now, scholars have debated the ethics of making heritable changes to the human genome. The arguments that have been raised both for and against the use of (...) genetic technologies in human reproduction reiterate much of the arguments made in the pre-CRISPR debate. As such, it is instructive for South Africa to reflect on these arguments now, in considering our position on the regulation of the use of this novel biotechnology. There are two dominant schools of thought in this area, bioliberalism and bioconservatism. Bioconservatives raise concerns about the risks of genetic manipulation, and argue that it ought to be limited or prohibited to avert these risks to human health and human nature. Bioliberal scholars are more open to the prospect of genetic manipulation, because of its potential utility. In this article, I conclude that in liberal democracies such as our own, bioliberal arguments ought to be seriously considered when formulating policy on human genome editing because of the extent to which they resonate with our Constitutional values and human rights. I further suggest that there is a need for an enquiry into the relevance of African perspectives on the ethical questions that arise concerning germline genome editing. (shrink)

In this introduction, we cover some ways in which the topic of noise is discussed today, and then point to some important open questions about noise and its experience. We then provide a synopsis of the papers collected in the volume.