The articles in this issue reflect the results of the 25th Altenberg Workshop in Theoretical Biology on ‘‘The Meaning of ‘Theory’ in Biology’’ held at the Konrad Lorenz Institute for Evolution and Cognition Research, Altenberg, Austria, 30 June–3 July, 2011.

We defend a realistic attitude towards biological species. We argue that two species are not different species because they differ in intrinsic features, be they phenotypic or genomic, but because they are separated with regard to gene flow. There are no intrinsic species essences. However, there are relational ones. We argue that bearing a gene flow relation to conspecifics may serve as the essence of a species. Our view of the species as a Gene-Flow Community differs from Mayr’s definition of (...) the species as a reproductive community. In a reproductive community, each organism is able to successfully reproduce with each other. However, there are species in which geographically distant organisms lost their ability to successfully reproduce, due to strong genetic adaptations to the respective local environmental conditions. Despite this loss of the ability to mutually reproduce, they are still bound by gene flow via continuous intermediate populations. This replacement of Mayr’s notion of an interbreeding potential as a criterion for species membership has important implications for the treatment of populations in allopatry and sympatry. (shrink)

Zuse proposed that the universe is being computed by some sort of cellular automaton or other discrete computing machinery, challenging the long-held view that some physical laws are continuous by nature. Calculating Space is the title of MIT's English translation of Konrad Zuse's 1969 Rechnender Raum, the first work on digital physics. This is the LaTeX edition by A. German and H. Zenil based on the MIT's English translation with permission from the MIT and Konrad Zuse's son Horst (...) Zuse. Followed by an afterword by A. German and H. Zenil. (shrink)

The practical aspect of ancient philosophy has been recently made a focus of renewed metaphilosophical investigation. After a brief presentation of three accounts of this kind developed by Martha Nussbaum, Pierre Hadot, and Michel Foucault, the model of the therapeutic argument developed by Nussbaum is called into question from the perspectives offered by her French colleagues, who emphasize spiritual exercise (Hadot) or the care of the self (Foucault). The ways in which the account of Nussbaum can be defended are then (...) discussed, including both a ‘negative’ defense, i.e. the indication of the weaknesses of Hadot and Foucault’s proposals, and a ‘positive’ one focused on the points in which Nussbaum can convincingly address doubts about her metaphilosophical account. In response to these analyses, some further remarks made by Hadot and Foucault are discussed in order to demonstrate that their accounts are not as distant from Nussbaum after all. Finally, a recent metaphilosophical study by John Sellars together with a therapeutic (medical) model developed by the author of the present article are suggested as providing a framework for potential reconciliation between all three accounts discussed and a resource for further metaphilosophical studies. (shrink)

We performed a qualitative analysis of the Thesaurus in order to assess its conformity with principles of good practice in terminology and ontology design. We used both the on-line browsable version of the Thesaurus and its OWL-representation (version 04.08b, released on August 2, 2004), measuring each in light of the requirements put forward in relevant ISO terminology standards and in light of ontological principles advanced in the recent literature. Version 04.08b of the NCI Thesaurus suffers from the same broad range (...) of problems that have been observed in other biomedical terminologies. For its further development, we recommend the use of a more principled approach that allows the Thesaurus to be tested not just for internal consistency but also for its degree of correspondence to that part of reality which it is designed to represent. (shrink)

The main purpose of this article is to undertake a conceptual investigation of the Berlin Wisdom Paradigm: a psychological project initiated by Paul Baltes and intended to study the complex phenomenon of wisdom. Firstly, in order to provide a wider perspective for the subsequent analyses, a short historical sketch is given. Secondly, a meta-theoretical issue of the degree to which the subject matter of the Baltesian study can be identified with the traditional philosophical wisdom is addressed. The main result yielded (...) by a careful conceptual analysis is that the philosophical and psychological concepts of wisdom, though not entirely the same, are at least parallel. Finally, one of the revealed aspects of the Berlin Wisdom Paradigm, i.e. its relative neglect of the non-cognitive and personal aspects of wisdom is brought to the fore. This deficiency, it is suggested, can be remedied by the application of the virtue ethics' conceptual framework. (shrink)

The Information Artifact Ontology (IAO) was created to serve as a domain‐neutral resource for the representation of types of information content entities (ICEs) such as documents, data‐bases, and digital im‐ages. We identify a series of problems with the current version of the IAO and suggest solutions designed to advance our understanding of the relations between ICEs and associated cognitive representations in the minds of human subjects. This requires embedding IAO in a larger framework of ontologies, including most importantly the Mental (...) Func‐tioning Ontology (MFO). It also requires a careful treatment of the aboutness relations between ICEs and associated cognitive representa‐tions and their targets in reality, which implies in turn a new treatment of the relation of truthmaking. (shrink)

The goal of referent tracking is to create an ever-growing pool of data relating to the entities existing in concrete spatiotemporal reality. In the context of Electronic Healthcare Records (EHRs) the relevant concrete entities are not only particular patients but also their parts, diseases, therapies, lesions, and so forth, insofar as these are salient to diagnosis and treatment. Within a referent tracking system, all such entities are referred to directly and explicitly, something which cannot be achieved when familiar concept-based systems (...) are used in what is called “clinical coding”. In this paper we describe the components of a referent tracking system in an informal way and we outline the procedures that would have to be followed by healthcare personnel in using such a system. We argue that the referent tracking paradigm can be introduced with only minor – though nevertheless ontologically important – technical changes to existing EHR infrastructures, but that it will require a radically different mindset on the part of those involved in clinical coding and terminology development from that which has prevailed hitherto. (shrink)

While classifications of mental disorders have existed for over one hundred years, it still remains unspecified what terms such as 'mental disorder', 'disease' and 'illness' might actually denote. While ontologies have been called in aid to address this shortfall since the GALEN project of the early 1990s, most attempts thus far have sought to provide a formal description of the structure of some pre-existing terminology or classification, rather than of the corresponding structures and processes on the side of the patient. (...) We here present a view of mental disease that is based on ontological realism and which follows the principles embodied in Basic Formal Ontology and in the application of BFO in the Ontology of General Medical Science. We analyzed statements about what counts as a mental disease provided in the research agenda for the DSM-V, and in Pies' model. The results were used to assess whether the representational units of BFO and OGMS were adequate as foundations for a formal representation of the entities in reality that these statements attempt to describe. We then analyzed the representational units specific to mental disease and provided corresponding definitions. Our key contributions lie in the identification of confusions and conflations in the existing terminology of mental disease and in providing what we believe is a framework for the sort of clear and unambiguous reference to entities on the side of the patient that is needed in order to avoid these confusions in the future. (shrink)

W tekście rozważane są zagadnienie realności i związana z nim tematyka epistemologiczna w trzecim okresie filozofii Fryderyka Nietzschego. Analizując ten obszar filozofii Nietzschego, autor zwraca szczególną uwagę na problem życia. Opisuje go za pomocą metafory pnącej się wzwyż spirali. Metafora ta rozwijana jest przez autora w kontekście koncepcji „ekstatycznego tańca kratofanicznego” Zbigniewa Kaźmierczaka. Autor rozpoczyna rozważania od interpretacji stanowiska Nietzschego na temat trzech władz poznawczych: świadomości, rozumu i języka metafizycznego. Następnie stara się opisać wpływ, jaki — zdaniem filozofa — wywierają (...) one na powstanie koncepcji realności. Z tego powodu przechodzi do analizy struktury woli. W ostatniej części tekstu autor dokonuje analizy koncepcji realności, zestawiając wyniki badań z metaforą spirali. (shrink)

Digital Rights Management (DRM) covers the description, identification, trading, protection, monitoring and tracking of all forms of rights over both tangible and intangible assets. The Digital Object Identifier (DOI) system provides a framework for the persistent identification of entities involved in this domain. Although the system has been very well designed to manage object identifiers, some important questions relating to the creation and assignment of identifiers are left open. The paradigm of a Referent Tracking System (RTS) recently advanced in the (...) healthcare and life sciences environment is able to fill these gaps. This is demonstrated by pointing out inconsistencies in the existing DOI models and by showing how they can be corrected using an RTS. (shrink)

Conceptual analysis, like any exclusively theoretical activity, is far from overrated in current psychology. Such a situation can be related both to the contingent influences of contextual and historical character and to the more essential metatheoretical reasons. After a short discussion of the latter it is argued that even within a strictly empirical psychology there are non-trivial tasks that can be attached to well-defined and methodologically reliable, conceptual work. This kind of method, inspired by the ideas of Ludwig Wittgenstein, Peter (...) Strawson (conceptual grammar), and Gilbert Ryle (conceptual geography), is proposed and formally depicted as being holistic, descriptive, and connective. Finally, the newly presented framework of connective conceptual analysis is defended against the “Charge from Psychology,” in a version developed by William Ramsey, claiming that conceptual analysis is based on psychological assumptions that have already been refuted by empirical psychology. (shrink)

Quality assurance in large terminologies is a difficult issue. We present two algorithms that can help terminology developers and users to identify potential mistakes. We demon­strate the methodology by outlining the different types of mistakes that are found when the algorithms are applied to SNOMED-CT. On the basis of the results, we argue that both formal logical and linguistic tools should be used in the development and quality-assurance process of large terminologies.

In this paper I consider how theology impacted on the uprising philosophy in ancient Greece. In the €rst part of my text I analyze the concept of theology and philosophy and I want to know the relation between these two ideas. I am especially interested in point of the line separating theology and philosophy. e main question concerning it is when we could say about theology that it is already philosophy, and reversely – when we could say about philosophy that (...) it is still theology in Greek meaning. For the better understanding of the answer of this question I analyze Hesiod’s Teogony. Hesiod of Beotia is accepted as a poet and theologian and that is why I pay attention to him in the second part of my text. (shrink)

As we look beyond our terrestrial boundary to a multi-planetary future for humankind, it becomes paramount to anticipate the challenges of various human factors on the most likely scenario for this future: permanent human settlement of Mars. Even if technical hurdles are circumvented to provide adequate resources for basic physiological and psychological needs, Homo sapiens will not survive on an alien planet if a dysfunctional psyche prohibits the utilization of these resources. No matter how far we soar into the stars, (...) our psychologies for future generations will be forever tethered to the totality of our surroundings. By shaping our environment toward survival and welfare during the voyage to Mars and in a Martian colony, we indirectly shape our psyches and prepare them for a mission of unprecedented alienation and duration. Once on Mars, human factors such as leadership structure, social organization and code of conduct, group size, gender balance, developmental cycle, mobility, length of stay and the ecological settings and type and manner of subsistence, will create a novel Martian culture. The degree that settlers are severed from the Earth will affect how radically foreign this culture will be when compared with cultures on Earth. (shrink)

Ontology is currently perceived as the solution of first resort for all problems related to biomedical terminology, and the use of description logics is seen as a minimal requirement on adequate ontology-based systems. Contrary to common conceptions, however, description logics alone are not able to prevent incorrect representations; this is because they do not come with a theory indicating what is computed by using them, just as classical arithmetic does not tell us anything about the entities that are added or (...) subtracted. In this paper we shall show that ontology is indeed an essential part of any solution to the problems of medical terminology – but only if it is understood in the right sort of way. Ontological engineering, we shall argue, should in every case go hand in hand with a sound ontological theory. (shrink)

PURPOSE—A substantial fraction of the observations made by clinicians and entered into patient records are expressed by means of negation or by using terms which contain negative qualifiers (as in “absence of pulse” or “surgical procedure not performed”). This seems at first sight to present problems for ontologies, terminologies and data repositories that adhere to a realist view and thus reject any reference to putative non-existing entities. Basic Formal Ontology (BFO) and Referent Tracking (RT) are examples of such paradigms. The (...) purpose of the research here described was to test a proposal to capture negative findings in electronic health record systems based on BFO and RT. METHODS—We analysed a series of negative findings encountered in 748 sentences taken from 41 patient charts. We classified the phenomena described in terms of the various top-level categories and relations defined in BFO, taking into account the role of negation in the corresponding descriptions. We also studied terms from SNOMED-CT containing one or other form of negation. We then explored ways to represent the described phenomena by means of the types of representational units available to realist ontologies such as BFO. RESULTS—We introduced a new family of ‘lacks’ relations into the OBO Relation Ontology. The relation lacks_part, for example, defined in terms of the positive relation part_of, holds between a particular p and a universal U when p has no instance of U as part. Since p and U both exist, assertions involving ‘lacks_part’ and its cognates meet the requirements of positivity. CONCLUSION—By expanding the OBO Relation Ontology, we were able to accommodate nearly all occurrences of negative findings in the sample studied. (shrink)

Based on the Ontology for General Medical Science, we propose definitions for biomarkers of various types of. These definitions provide not only a complete formal representation of what biomarkers are according to the Institute of Medicine (IOM), but also remove the ambiguities and inconsistencies encountered in the documentation provided by the IOM.

Werner Heisenberg made an important – and as yet insufficiently researched – contribution to the transformation of the modern conception of science. This transformation involved a reassessment of the status of scientific knowledge from certain to merely hypothetical – an assessment that is widely recognized today. I examine Heisenberg’s contribution in particular by taking his conception of “closed theories” as an example according to which the established physical theories have no universal and exclusive, but only a restricted validity. Firstly, (...) I characterize the historical process of hypothetization of claims to validity. Then, secondly, I reconstruct Heisenberg’s conception, as far as it can be derived from his popular writings, relating it to the process of hypothetization. Finally, I touch on the history of its reception and compare it with conceptions of science that emphasize the significance of the hypothetical for the modern theories of natural sciences. Compared to these conceptions, Heisenberg’s contribution turns out to be rather independent. (shrink)

Werner Heisenberg hat einen wichtigen, noch nicht hinreichend untersuchten Beitrag zum Wandel des neuzeitlichen Wissenschaftsverständnisses geleistet. Der Wandel führte von der Charakterisierung des wissenschaftlichen Wissens als sichere Erkenntnis zu seiner - heute weithin anerkannten - Charakterisierung als bloß hypothetische Erkenntnis. Anfänge dieses Wandlungsprozesses lassen sich im 19. Jahrhundert nachweisen (z.B. bei John Hersehel, William Whewell oder Hermann von Helmholtz). Ich möchte am Beispiel von Heisenberg der Frage nachgehen, welchen Einfluss die Begründung der Quantenmechanik, die seine Wissenschaftsauffassung prägte, auf den (...) Prozess der Relativierung von Geltungsansprüchen hatte. Meine Vermutung ist, dass eine entscheidende Rolle hierbei weniger dem Wahrscheinlichkeitsbegriff als vielmehr dem Wahrheits- und Realitätsbegriff zukam. Ich werde als erstes den historischen Prozess der Hypothetisierung von Geltungsansprüchen, zu dem ich Heisenbergs Konzeption ins Verhältnis setzen möchte, charakterisieren. Anschließend rekonstruiere ich Heisenbergs Konzeption, soweit sie sich seinen populären Reden und Aufsätzen entnehmen lässt. Als drittes werde ich ihre Wirkungsgeschichte kurz ansprechen und sie mit Wissenschaftsauffassungen vergleichen, die die Bedeutung des Hypothetischen für die modernen Theorien der Naturwissenschaften betonen. Ihnen gegenüber erweist sich Heisenbergs Beitrag als durchaus eigenständig. (shrink)

We present the details of a methodology for quality assurance in large medical terminologies and describe three algorithms that can help terminology developers and users to identify potential mistakes. The methodology is based in part on linguistic criteria and in part on logical and ontological principles governing sound classifications. We conclude by outlining the results of applying the methodology in the form of a taxonomy different types of errors and potential errors detected in SNOMED-CT.

Electronic Health Records (EHRs) are organized around two kinds of statements: those reporting observations made, and those reporting acts performed. In neither case does the record involve any direct reference to what such statements are actually about. They record not: what is happening on the side of the patient, but rather: what is said about what is happening. While the need for a unique patient identifier is generally recognized, we argue that we should now move to an EHR regime in (...) which all clinically salient particulars – from the concrete disorder on the side of the patient and the body parts in which it occurs to the concrete treatments given – should be uniquely identified. This will allow us to achieve interoperability among different systems of records at the level where it really matters: in regard to what is happening in the real world. It will also allow us to keep track of particular disorders and of the effects of particular treatments in a precise and unambiguous way. We discuss the ontological and epistemological aspects of our claim and describe a scenario for implementation within EHR systems. (shrink)

The paradigm of referent tracking is based on a realist presupposition which rejects so-called negative entities (congenital absent nipple, and the like) as spurious. How, then, can a referent tracking-based Electronic Health Record deal with what are standardly called ‘negative findings’? To answer this question we carried out an analysis of some 748 sentences drawn from patient charts and containing some form of negation. Our analysis shows that to deal with these sentences we need to introduce a new ontological relationship (...) between a particular and a universal, which holds when no instance of the universal has a specific qualified ontological relation with the particular. This relation is found to be able to accommodate nearly all occurrences of negative findings in the examined sample, in ways which involve no reference to negative entities. (shrink)

If SNOMED CT is to serve as a biomedical reference terminology, then steps must be taken to ensure comparability of information formulated using successive versions. New releases are therefore shipped with a history mechanism. We assessed the adequacy of this mechanism for its treatment of the distinction between changes occurring on the side of entities in reality and changes in our understanding thereof. We found that these two types are only partially distinguished and that a more detailed study is required (...) to propose clear recommendations for enhancement along at least the following lines: (1) explicit representation of the provenance of a class; (2) separation of the time-period during which a component is stated valid in SNOMED CT from the period it is (or has been) valid in reality, and (3) redesign of the historical relationships table to give users better assistance for recovery in case of introduced mistakes. (shrink)

The goal of the OBO (Open Biomedical Ontologies) Foundry initiative is to create and maintain an evolving collection of non-overlapping interoperable ontologies that will offer unambiguous representations of the types of entities in biological and biomedical reality. These ontologies are designed to serve non-redundant annotation of data and scientific text. To achieve these ends, the Foundry imposes strict requirements upon the ontologies eligible for inclusion. While these requirements are not met by most existing biomedical terminologies, the latter may nonetheless support (...) the Foundry’s goal of consistent and non-redundant annotation if appropriate mappings of data annotated with their aid can be achieved. To construct such mappings in reliable fashion, however, it is necessary to analyze terminological resources from an ontologically realistic perspective in such a way as to identify the exact import of the ‘concepts’ and associated terms which they contain. We propose a framework for such analysis that is designed to maximize the degree to which legacy terminologies and the data coded with their aid can be successfully used for information-driven clinical and translational research. (shrink)

Referent tracking (RT) is a new paradigm, based on unique identification, for representing and keeping track of particulars. It was first introduced to support the entry and retrieval of data in electronic health records (EHRs). Its purpose is to avoid the ambiguity that arises when statements in an EHR refer to disorders or other entities on the side of the patient exclusively by means of compound descriptions utilizing general terms such as ‘pimple on nose’ or ‘small left breast tumor’. In (...) this paper, we describe the theoretical foundations of this paradigm and show how it is being applied to the solution of analogous problems of ambiguous identification in the fields of digital rights management, corporate memories and decision algorithms. (shrink)

On the broken myth in the philosophy of religion and theology Abstract. The article deals with the concept of broken myth, thus named by the German theologian and philosopher Paul Tillich (1886 - 1965). The thesis related to this concept is that all religions, including Christianity, use a mythical language. This language is expressing moral truths and metaphysical intuitions, but not the objective facts and states of affairs that may provide knowledge. The broken myth does not imply the rejection of (...) myth as a mere untruth, but rather its split into untruth, which is the garment of the story understood literally, and truth, which is (although not always and to varying degrees) a moral and spiritual inspiration. The broken myth is self-aware, but not discredited. The author formulates six reasons that can speak in favor of such view. He believes that its acceptance by the community of believers can be very difficult, so the traditional discourse of faith, in which one understands literally credo articles (including the notions of mystery and analogy), must be considered not as an anachronism, but as an autonomous partner of dialogue. -/- . (shrink)

Definitive diagnosis of malaria requires the demonstration through laboratory tests of the presence within the patient of malaria parasites or their components. Since malaria parasites can be present even in the absence of malaria manifestations, and since symptoms of malaria can be manifested even in the absence of malaria parasites, malaria diagnosis raises important issues for the adequate understanding of disease, etiology and diagnosis. One approach to the resolution of these issues adopts a realist view, according to which the needed (...) clarifications will be derived from a careful representation of the entities on the side of the patient which form the ultimate truthmakers for clinical statements. We here address a challenge to this realist approach relating to the diagnosis of malaria, and show how this challenge can be resolved by appeal to Basic Formal Ontology (BFO) and to the Ontology for General Medical Science (OGMS) constructed in its terms. (shrink)

Gregor Schiemann führt allgemeinverständlich in das Denken dieses Physikers ein. Thema sind die Erfahrungen und Überlegungen, die Heisenberg zu seinen theoretischen Erkenntnissen geführt haben, die wesentlichen Inhalte dieser Erkenntnisse sowie die Konsequenzen, die er daraus für die Geschichte der Physik und das wissenschaftliche Weltbild gezogen hat. Heisenbergs Vorstellungswelt durchzieht durch ein Spannungsverhältnis, das heute noch das Denken vieler Wissenschaftlerinnen und Wissenschaftler bewegt. Er ist um ein umfassendes Verständnis der Naturprozesse bemüht, zugleich aber von der Berechenbarkeit und Beherrschbarkeit von Phänomenen auch (...) dann schon fasziniert, wenn die zugrunde liegenden Prozesse erst teilweise verstanden sind. Aus der Geschichte der Physik zieht er die wirkungsreiche Lehre, daß sich die naturwissenschaftliche Erkenntnis nicht kontinuierlich, sondern sprunghaft in Form von Revolutionen entwickelt. Die Reichweite des physikalischen Wissens begrenzt er in einer Schichtentheorie der Welt, nach der die komplexen Phänomene des Lebens nicht allein durch die Wechselwirkungen zwischen ihren Bestandteilen erklärt werden können. Der zunehmenden Technisierung der Welt steht Heisenberg kritisch gegenüber. Seiner Zeit weit voraus, glaubt er, daß die Technisierung der Welt eine epochal neue Stufe erreicht habe, in der der Mensch „nur noch sich selbst“ gegenüberstehe. (shrink)

Some features of Hegel’s Philosophy of History make it hardly acceptable in the 21st century. It proposes a final destination (Endzweck) of history, together with a principle of rational, dialectic necessity to take it there. In fact, these conceptions are not as absurd as they may seem to contemporary eyes. Nevertheless, the article doesn’t pretend to defend them, but aims to show that there is, behind these two, a third principle which is well worth to be defended –and which, in (...) fact, can systematically maintained without support from the other two. This we can call the “Principle of ethical asymmetry in history”. However, we also can name it by the formula Hegel himself coined: the “progress in the consciousness of liberty”. To explain this idea, the article evidences that the fundamental characteristic of all normativity is practical knowledge de se. In morality or ethics, this turns reflexive and self-determining. Liberty in Hegel’s sense effectively realizes this knowledge de se not only in a formal and abstract way, as in Kant, but concretely in history and in specific communities. However, since liberty in this process always remains linked to that normative self-comprehension which constitutes our practical self-consciousness, the processes of historical realization of liberty are normatively irreversible. Precisely for this process has an element of objective and unconditional aspect. The article concludes with some remarks as to how this principle of ethical asymmetry in history can serve as a basis of e new ethical theory which is strongly normative and, at the same time, sensitive to historic context an human finitude. (shrink)

A questão “por quê ser moral”, que foi formulada expressamente no contexto do debate filosófico acadêmico por Francis Herbert Bradley, divide os leitores quando buscam sua resposta em Kant. Uns acham, como Gerold Prauss, que Kant negue a possibilidade de tal resposta e diga que a moral precisa ser aceita como um fato simplesmente dado, o “fato da razão”. Contudo, como tal imediatismo ou “decisionismo transcendental” parece insatisfatório, um outro grupo defende a assim chamada “interpretação do agente racional”, onde este (...) último apresenta o valor supremo, absoluto, que fundamenta a moral e, com isso, apresenta a razão em virtude da qual devemos agir moralmente. Mas tal valor absoluto ou já é moral, mas então a resposta dada à questão “por quê ser moral” entra num círculo vicioso. Ou tal valor faz a moral depender de algo fora da moral o que, conforme Kant, destruiria toda moral. A solução do problema é a seguinte: Kant não deriva a moral de um pressuposto extramoral nem pressupõe a própria moral como simplesmente dada, mas explica o originar da moral. Ela origina da razão prática pela volta dessa razão sobre si mesma que constitui sua autonomia. Por este seu originar, a moral não é uma mera derivação de algo pressuposto, mas algo radicalmente novo, original, autónomo. Pelo outro lado, existe, sim, uma fundamentação da moral, i.e., um processo compreensível de sua constituição. Com isso, Kant evita o imediatismo: a moral não precisa ser simplesmente aceita como um fato puro, mas pode ser compreendida pela razão. (shrink)

The author presents a schematic outline of two approaches in contemporary philosophy of technology, the first of which is rather pessimistic, with technological progress seen as a rising force which subjugates humans and, to use Martin Heidegger’s words, “hampers, oppresses and drags them along in its tracks.” Also underscored is the failing relation between scientific and technological progress and moral development. The second approach, presented in reference to the thoughts of Pierre Teilhard de Chardin, interprets scientific and technological progress as (...) the creation of tools enabling the unity of mankind and further evolution. The author supports Teilhard’s view, which he sees as a better motivation to build a better world. (shrink)

For corporate memory and enterprise ontology systems to be maximally useful, they must be freed from certain barriers placed around them by traditional knowledge management paradigms. This means, above all, that they must mirror more faithfully those portions of reality which are salient to the workings of the enterprise, including the changes that occur with the passage of time. The purpose of this chapter is to demonstrate how theories based on philosophical realism can contribute to this objective. We discuss how (...) realism-based ontologies (capturing what is generic) combined with referent tracking (capturing what is specific) can play a key role in building the robust and useful corporate memories of the future. (shrink)

Kant mostra que uma teoria fundamental da normatividade e da moralidade não pode dar nem uma explanação nem uma prova da normatividade, mas apenas pode articular e explicitar sua origem. Ela pode fazer isso indicando o lugar ou o topos e a virada ou a trope de seu originar. Conforme Kant, o topos da normatividade é a vontade enquanto razão prática e sua trope é o uso geral desta razão que tipicamente é instrumental, no sentido da reflexão. A trope da (...) origem da moralidade é a autonomia, i.e., a virada da razão prática sobre si mesma, tornando-se pura neste ato. Nisso, a razão prática estabelece sua própria forma como lei para si mesma, na forma do imperativo categórico. Em consequência disso, a ética fundamental serve duas funções : formalmente, ela fornece evidência da originalidade e autenticidade da moralidade; materialmente, ela fornece um princípio criteriológico para o conteúdo da moralidade. O artigo argumenta que Kant estava certo em sua visão da fundamentação da ética, mas estava errado com relação à maneira como ele tentou cumprir as exigências estabelecidas. O topos da normatividade e, em consequência disso, da moralidade, não pode ser a razão, mas precisa ser a consciência ou, mais exatamente, o saber de se ; e sua trope fundamental não pode ser reflexão e, depois, autonomia, mas precisa ser o que pode ser descrito como conversão da consciência. Essa conversão pode ser identificada com o philein no sentido de Aristóteles. Este “amar amigável” tem quatro aspectos diferentes: desejo, cognição, benevolência e reconhecimento. Quando este philein for recíproco e estiver continuamente vivido, nasce a philia, a amizade. Essa é descrita, consequentemente, como o topos da origem de normatividade e moralidade. (shrink)

My contention is to adumbrate three general premises leading to religious tolerance. The first is that emphasis should be laid much more on ethics than on metaphysics. Religions greatly differ in supernatural beliefs but all advocate justice, love, truthfulness, self-control and other virtues. Second, the beliefs about God are not true in their exact meaning, but rather as remote analogies to scientific truth. Religion is more resemblant of poetry than science. Third, real tolerance consists in the readiness to assimilate some (...) of the values of other religions, since no one has expressed the transcendent in an exhausting and perfect way. Key Words: tolerance, ethics, objective knowledge, world religions, openness for the Other. (shrink)

Ontological realism aims at the development of high quality ontologies that faithfully represent what is general in reality and to use these ontologies to render heterogeneous data collections comparable. To achieve this second goal for clinical research datasets presupposes not merely (1) that the requisite ontologies already exist, but also (2) that the datasets in question are faithful to reality in the dual sense that (a) they denote only particulars and relationships between particulars that do in fact exist and (b) (...) they do this in terms of the types and type-level relationships described in these ontologies. While much attention has been devoted to (1), work on (2), which is the topic of this paper, is comparatively rare. Using Referent Tracking as basis, we describe a technical data wrangling strategy which consists in creating for each dataset a template that, when applied to each particular record in the dataset, leads to the generation of a collection of Referent Tracking Tuples (RTT) built out of unique identifiers for the entities described by means of the data items in the record. The proposed strategy is based on (i) the distinction between data and what data are about, and (ii) the explicit descriptions of portions of reality which RTTs provide and which range not only over the particulars described by data items in a dataset, but also over these data items themselves. This last feature allows us to describe particulars that are only implicitly referred to by the dataset; to provide information about correspondences between data items in a dataset; and to assert which data items are unjustifiably or redundantly present in or absent from the dataset. The approach has been tested on a dataset collected from patients seeking treatment for orofacial pain at two German universities and made available for the NIDCR-funded OPMQoL project. (shrink)

The global spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or coronavirus disease 19 (COVID-19) has led to the imposition of severely restrictive measures by governments in the Western hemisphere. We feel a contrast between these measures and our freedom. This contrast, we argue, is a false perception. It only appears to us because we look at the issue through our contemporary moral philosophy of utilitarianism and an understanding of freedom as absence of constraints. Both these views can be (...) substituted with more sophisticated alternatives, namely an ethics of virtue and a notion of freedom of the will. These offer a fuller picture of morality and enable us to cooperate with the current restrictions by consciously choosing to adhere to them instead of perceiving them as draconian and immoral. We ask whether we should collaborate with the restrictions and argue that considerations of virtue will lead to an affirmative answer. More broadly, virtue ethics permits to deal with the practical concerns about how an individual should behave during this pandemic, given the current lockdown measures or lack thereof. -/- In section 1, we present how utilitarianism and a notion of freedom as negative liberty support the opposition to restrictive measures. In section 2, we outline an alternative based on an ethics of virtue and a more elaborated notion of free will. In the concluding section 3, we argue that considerations of virtue should guide the individual and public response to the emergency. (shrink)

The integration of information resources in the life sciences is one of the most challenging problems facing bioinformatics today. We describe how Language and Computing nv, originally a developer of ontology-based natural language understanding systems for the healthcare domain, is developing a framework for the integration of structured data with unstructured information contained in natural language texts. L&C’s LinkSuite™ combines the flexibility of a modular software architecture with an ontology based on rigorous philosophical and logical principles that is designed to (...) comprehend the basic formal relationships that structure both reality and the ways humans perceive and communicate about reality. (shrink)

One way to detect, monitor and prevent adverse events with the help of Information Technology is by using ontologies capable of representing three levels of reality: what is the case, what is believed about reality, and what is represented. We report on how Basic Formal Ontology and Referent Tracking exhibit this capability and how they are used to develop an adverse event ontology and related data annotation scheme for the European ReMINE project.

Ontologies are today being applied in almost every field to support the alignment and retrieval of data of distributed provenance. Here we focus on new ontological work on dance and on related cultural phenomena belonging to what UNESCO calls the “intangible heritage.” Currently data and information about dance, including video data, are stored in an uncontrolled variety of ad hoc ways. This serves not only to prevent retrieval, comparison and analysis of the data, but may also impinge on our ability (...) to preserve the data that already exists. Here we explore recent technological developments that are designed to counteract such problems by allowing information to be retrieved across disciplinary, cultural, linguistic and technological boundaries. Software applications such as the ones envisaged here will enable speedier recovery of data and facilitate its analysis in ways that will assist both archiving of and research on dance. (shrink)

Health Level 7 (HL7) is an organization seeking to provide universal standards for the exchange of healthcare information. In a document entitled ‘HL7 Version 3 Standard: Data Types’, the HL7 organization advances descriptions of data types recom- mended for use as identifiers. We will argue that the descriptions supplied provide insufficient guidance as to what exactly the entities are which these data types uniquely identify. Are they real things, such as persons or pieces of equipment? Or are they representations of (...) such real things in information artifacts? We here outline the problems faced by HL7 in providing answers to such questions, problems which arise because of the lack of anything like a coherent ontology in the HL7 standard, and we make some recommendations for future improvements. (shrink)

Semantic interoperability can be defined as the ability of two or more computer systems to exchange information in such a way that the meaning of that information can be automatically interpreted by the receiving system accurately enough to produce useful results to the end users of both systems. Several activities are currently being performed by a variety of stakeholders to achieve semantic interoperability in healthcare. Many of these activities are not beneficial, because they place too great a focus on business (...) aspects and not enough on involvement of the right sorts of researchers, in particular those that are able to see how the data and information relate to the entities of concern on the side of the patient. The lack of a central focus on the patient, and the associated focus on ‘concepts’, have spawned a variety of mutually incompatible terminologies exhibiting non-resolvable overlap. The predominance of the healthcare IT industry in the writing and selection of semantic interoperability standards mitigates against the benefits that standards, when well designed, can bring about. (shrink)

Description logics and other formal devices are frequently used as means for preventing or detecting mistakes in ontologies. Some of these devices are also capable of inferring the existence of inter-concept relationships that have not been explicitly entered into an ontology. A prerequisite, however, is that this information can be derived from those formal definitions of concepts and relationships which are included within the ontology. In this paper, we present a novel algorithm that is able to suggest relationships among existing (...) concepts in a formal ontology that are not derivable from such formal definitions. The algorithm exploits cross-lingual information that is implicitly present in the collection of terms used in various languages to denote the concepts and relationships at issue. By using a specific experimental design, we are able to quantify the impact of cross-lingual information in coping with underspecification in formal ontologies. (shrink)

One way to detect, monitor and prevent adverse events with the help of Information Technology is by using ontologies capable of representing three levels of reality: what is the case, what is believed about reality, and what is represented. We report on how Basic Formal Ontology and Referent Tracking exhibit this capability and how they are used to develop an adverse event ontology and related data annotation scheme for the European ReMINE project.

To enhance the treatment of relations in biomedical ontologies we advance a methodology for providing consistent and unambiguous formal definitions of the relational expressions used in such ontologies in a way designed to assist developers and users in avoiding errors in coding and annotation. The resulting Relation Ontology can promote interoperability of ontologies and support new types of automated reasoning about the spatial and temporal dimensions of biological and medical phenomena.

Equipped with the ultimate query answering system, computers would finally be in a position to address all our information needs in a natural way. In this paper, we describe how Language and Computing nv (L&C), a developer of ontology-based natural language understanding systems for the healthcare domain, is working towards the ultimate Question Answering (QA) System for healthcare workers. L&C’s company strategy in this area is to design in a step-by-step fashion the essential components of such a system, each component (...) being designed to solve some one part of the total problem and at the same time reflect well-defined needs on the prat of our customers. We compare our strategy with the research roadmap proposed by the Question Answering Committee of the National Institute of Standards and Technology (NIST), paying special attention to the role of ontology. (shrink)

The ending of the Phaedo is one of the most powerful and memorable moments in the entire Platonic corpus. It is not simply the end of a single dialogue, but a depiction of the end of the life of the man (Socrates) who is a looming presence in nearly everything that Plato wrote. In this article I offer an in-depth analysis of the final scene of the Phaedo. I argue that Plato very carefully constructs the scene for the sake of (...) specific philosophical, dramatic, and political ends. Plato uses it to unify the Phaedo as a singular text, while also provoking us to reflect on the nature of our lives, our deaths, and the possibilities and limits of philosophy itself. (shrink)

What ideas of morality and ethics existed under National Socialism? This annotated volume of sources presents for the first time a biographically contextualized selection of texts by academic moral philosophers who distinguished themselves particularly during the "Third Reich". The examination of their ideologues helps to better understand the connection between normative self-understanding and the crimes of National Socialism. In addition, the book enables a differentiated view of the development of moral philosophy after 1945.

Many eminent philosophers of religion and theologians have postulated metaphorical understanding of religious dogmas instead of a literal one. Despite differences all have been sympathetic to Christian moral tradition and to religion in general. They proclaim a "third way" beyond traditional theism and atheism. The metaphorical approach to religious beliefs has gathered momentum in the context of the processes of globalization. The Church however defends traditional, literal interpretation of its dogmas. First, the difference between literal and metaphorical understanding of religious (...) dogmas is explained. Then reasons for and against each position are examined with a conclusion that instead of the “subsumption” of the one paradigm by another, for the undefinite future both should be treated as a justified and autonomous discourses remaining in a dialogue. (shrink)