Objective: The use of neoadjuvant chemotherapy (NACT) in breast cancer is increasing. The management of locally advanced breast cancer differs due to the approach of the center to which the patient applied and the approach of the following physician. From this point of view, we aimed to evaluate the real life data of our region. -/- Methods: The study included 106 patients treated with neoadjuvant chemotherapy in the medical oncology clinic of two different university hospitals. Association between clinicopathological features and (...) pathological complete response (pCR) were analyzed. -/- Results: The pCR rate was higher in patients with negative hormone receptors and this difference was statistically significant (p:0.000). The rate of obtaining pCR increased as the NACT duration increased, and this increase was statistically significant. The mean NACT duration applied to the patients with pCR was 5.48 ± 0.22 months, and the mean NACT duration for those who could not obtain pCR was 5.01 ± 0.1 months (p:0.041). The recurrence rate of patients with pCR was 11.1%, while the recurrence rate of patients who could not obtain pCR was 31.6% (p:0.04). -/- Conclusions: Pathological response to chemotherapy is an important factor in determining prognosis. There appears to be a need for new biomarkers that allow the prediction of pCR and long-term outcomes. (shrink)

Taxonomically, lichens are classified as a distinct group under the Kingdom Fungi. They have been subject to materia medica books since the ancient times, drawing attention for their medicinal properties. Studies on the biology and history of lichens in Türkiye have now reached a significant level. Therefore, it is epistemologically plausible to consider lichens in philosophy and from a philosophical perspective. The dual nature of lichens known as symbiotic organisms leads to the emergence of certain properties that are not observable (...) when individual partners live separately. The present study explores whether lichens are indivisible individuals, discussing the lichen thallus as a relatively balanced system and even a miniature ‘ecosystem’. Consequently, this paper proposes that emergence, as a concept, can be considered a methodological apparatus in both defining and explaining biological facts and phenomena. Building on biological knowledge, it is suggested that philosophy, particularly biophilosophy and ethics, can consider lichens as model organisms. Through this perspective, principles for coexistence of both individuals, communities, and societies can be established. (shrink)

Biology, or life science, has particularly marked the twentieth and twenty-first centuries as a discipline. Due to its focus on the study of living entities, it distinguishes itself from other natural sciences in terms of subject matter, methods, and scope. The importance of biology is likely to continue growing in the coming years and centuries, leading to an increased interest in the history and philosophy of biology. Consequently, there is a need to illuminate methods that shed light on the history (...) and philosophy of biology. Drawing inspiration from Aristotle’s perspective on knowledge, this study proposes three distinct viewpoints in the history of biology. These perspectives are named the Nonteleological- Contingent View, Nominalistic-Terminologistic View, and Contentual-Contextual View. Accordingly, the roots of biology can be traced back to Aristotle. It is argued that biology can be considered a science initiated by Aristotle, and the extent of Aristotle’s contributions to the field of biology is indicated with references to the page count of his works in this domain. Furthermore, attention is drawn to the intellectual continuity between Aristotle and Ibn Sina (Avicenna), emphasizing Ibn Sina’s role as a scholar who produced original works through updates and syntheses. (shrink)

Recent studies in the History of Botany put forth that the books translated to and authored in Arabic have circulated from the East of the Caspian Sea, to the centre of Iberian Peninsula, strengthening the ‘traditional uses’ of plants and alike. An ancient genre of writing called the ‘book on the Materia medica’ was especially the most favourite in Medieval Islamic Geography. In these books, algae have been mentioned among the kinds of medicinal plants. In this study, I investigate several (...) Materia medica books among which I shall first focus on Avicenna’s Canon of Medicine, then have a look at Aliboron’s Book of Pharmacy since these two were contemporary sources from the 11th century. I shall also investigate two illustrated sources, an Arabic copy of Dioscorides’ Materia Medica and al-Ghafiqi’s Book on Simple Drugs, both from the 13th century. In doing so, on the one hand, I will be able to compare the drawings of algae, and on the other I will shed light on the transfer of knowledge on algae. These two methods will result in the textual apparatus and the illustrative apparatus in my study. (shrink)

There is no doubt that custard apple diseases are among the important reasons that destroy the Custard Apple plant and its agricultural crops. This leads to obvious damage to these plants and they become inedible. Discovering these diseases is a good step to provide the appropriate and correct treatment. Determining the treatment with high accuracy depends on the method used to correctly diagnose the disease, expert systems can greatly help in avoiding damage to these plants. The expert system correctly diagnoses (...) Custard Apple disease to make it easier for farmers to find the right treatment based on the appropriate diagnosis. Objectives: A specialized syllable language system was established for the diagnosis of Custard Apple plant disease. (shrink)

The term biodiversity, also known as the diversity of life, is often used to mean the diversity of the living beings in the biosphere. By diversity of the living beings, it is meant mostly living things as individuals. In addition, it is possible to discuss the diversity of species, ecosystems, and hereditary characteristics. In this study, answers were sought to questions such as ‘Is biodiversity a value, can it be measured, what does it mean for our country and the world, (...) what is the lack or lack of biodiversity’. Thus, it was emphasized that biodiversity should be accepted as a value per se. In direct connection with biodiversity, it has been argued that ecosystems should be protected through a combination of intervening and non-intervening methods. In addition, by referring to the nature - culture dichotomy, nature's being the source of culture is underlined. It was mentioned that ecosystems should be protected in order to protect the number of species, and for this reason, intensive consumption of biosphere resources should be prevented. It has been argued that the point of distinction in conservation studies should be determined as ens viva, the concept of being alive. As a result, a proposal consisting of nine items has been put forth in order that it should be considered while drawing a possible roadmap. (shrink)

Biology –in its simplest definition– is a natural science that studies the living things. Philosophy of Biology, on the other hand, is the whole of conceptual analysis, synthesis and deductions that filters the scientific information being produced by biology, especially those of ‘life’ and ‘evolution’. In this study, the importance of the philosophy-science view of the famous philosopher Teoman Duralı, who passed away a year ago, will be mentioned in terms of contemporary biology and philosophy of biology. In doing this, (...) first of all, the historical relationship between the philosophy of biology and the philosophy of science will be revealed. Then having in consideration of the scope of the philosophy of biology, its relationship to the pure biology and to the history of biology will be mentioned. Then, Duralı’s philosophy-science view will be examined in terms of meaning and cause-effect relationships, thus both his contribution to the philosophy of biology literature in Turkish and his position will be pointed out. In conclusion, the use of the term biophilosophy, which concerns and connects two separate-but-adjoint flowing rivers ‘the philosophy’ and ‘the biology’, will be mentioned by pointing out why ‘biology for philosophy’ and why ‘philosophy for biology’ are important reciprocally. Finally, a declaration consisting a list of ten proposed items will be put forth. (shrink)

In this study, it is tried to put forth some explanations on the definition of vitality referring to the historical definition of biology that can be considered as thestudy of life. In accordance with the explanations, the necessity of revision and distinction of some terms in the contemporary biology is also mentioned. The first among which is the updating of the term known as homeostasis into homeokinesis. For this reason, a number of propositions are emphasized in order to clarify the (...) distinction of meaning. The following three questions were repeated in the process and structure of the article: 1) What is vitality? 2) Does it have any degrees or grades? 3) If so, what is the basic-vitality? In the search for an answer to these questions, different topics of biology are cited as references. At the same time, by claiming that vitality is an emergent process, it is proposed to follow the emergentist view, rather than the reductionist view on the statements of biological facts and phenomena. As a result, the cell level in the hierarchy of the biological organization is discussed first and a threefold-vitality view emergent in the levels of cell, organ and organism is put forth. Consciousness and memory are immanent in every level of the proposed threefold-vitality. -/- Keywords: Life, Cell, Homeokinesis, Consciousness. (shrink)

Prescription drug misuse has emerged as a significant problem over the past decade, particularly topical corticosteroids for skin lightening. This study aimed to assess the misuse of topical corticosteroids among the female population in southern Libya; to determine prevalence, awareness, attitude, and practice regarding this drug misuse. A descriptive, cross-sectional questionnaire was distributed on January 2022 to females aged between 16-45 years old in southern Libya. Out of 200 distributed questionnaires, 155 were returned with a response rate of 77.5%. The (...) majority of the participants were aged 16-25 years (n=138, 89.0%) and over two-thirds of participants, said they obtained lightening products containing cortisone from pharmacies (n=107, 69.0%) while 36 participants indicated they obtained these products from cosmetic shops (23.2%). More than three-quarters of the participants said they were aware that they should read product ingredients (n=120, 77.4%). Just over one-quarter of respondents indicated they used the product on their face almost daily (n=41, 26.5%) while 28 participants denied using it (18.1%). The most common source of information about topical corticosteroids among participants was the Internet (n=51, 32.9%), followed by dermatologists (n=41, 26.5%), and pharmacists (n=31, 20.0%). Almost half of respondents were aware that topical corticosteroids can cause harmful effects (n=75, 48.4%). The most common indications reported for using topical corticosteroids were whitening (23.3%), and acne treatment (54.2%). Over two-thirds of participants, declared they would not use topical lightening products if they contained corticosteroids (n=107, 69.0%). In a similar attitude, nearly a third of participants stated that they would never use corticosteroid medications again if they knew about the negative effects of whitening (n=51, 32.9%). The majority of females, (87.7%), concur that only pharmacies should be able to sell and prescribe topical corticosteroid medications. The study's findings indicate that topical corticosteroids are frequently misused and that to lessen contraindications, especially for prolonged use, it is imperative to provide basic care to females who continue using topical corticosteroids in public or unlicensed marketing settings. (shrink)

It is now widely accepted that astronomical factors trigger the emergence of glacial and interglacial periods. However, nearly two centuries ago, the overall situation was not as apparent as it is today. In this article, I briefly discuss the astronomical model of ice ages put forward in the 19th and early 20th centuries. This period was indeed anni mirabiles for scientists to understand the ice age phenomenon. Agassiz, Adhémar and Croll laid the foundation stones for understanding the dynamics of ice (...) ages. But it was Milankovitch who combined empirical geology with mathematical astronomy. Specifically, he identified the shortcomings of the preceding ice age models and modified his model accordingly. In what follows, I review earlier approaches to the ice age problem and show how they failed to meet their objectives. Next, I show how Milankovitch's model managed to capture all sufficient astronomical elements. The final sections focus on Milutin Milankovitch's successful approach, including his accomplishment of tackling the problem mathematically. (shrink)

Zihin–beden problemi felsefenin en köklü ve temel problemlerinden biridir. Köklü geçmişine rağmen probleme getirilen yanıtlar hususunda felsefe literatüründe bütünüyle bir uzlaşımın olmadığını söylemek ise pekâlâ mümkündür. Zihin–beden problemi en basit haliyle şöyle ifade edilebilir: Birbirinden her özelliği ile ayrılan zihin ve beden birbirlerini etkiler mi ve eğer etkiler ise bu etkileşim nasıl olmaktadır? Neredeyse her felsefi mesele gibi, zihin–beden probleminin geçmişi de Antik Grek felsefesine kadar götürülebilir. Ancak söz konusu problem ile ilgili yapılmış detaylı çalışmalar ilk olarak rasyonalist filozoflar tarafından (...) yapılmıştır ve daha sonra empirist felsefeye doğru genişlemiştir. Bu yazıda ilk kesim filozofların, yani rasyonalistlerin, problemi ortaya koyuş biçimleri ve söz konusu probleme getirmiş oldukları yaklaşımlar incelenecektir. Bunu yaparken dört temel rasyonalist filozofun argümanları analiz edilecektir. Daha detaylı bir ifadeyle, bu yazının konusu Descartes’ın, Malebranche’ın, Spinoza’nın ve Leibniz’in zihin–beden problemine sunmuş oldukları çözüm önerilerini incelemek olacaktır. Son kısımda ele almış olduğum dört filozofun felsefi pozisyonlarındaki farklılıklara kısaca değinilecek, zihin–beden probleminin çeşitli implikasyonları ele alınıp güncel felsefedeki problemler ile bağlantısı gösterilecektir. (shrink)

In this study, after a short introductory information on the etymology, origin, and transition of botanical knowledge in Medieval Islamic Civilisation, we made a comparison of illustrated botanical works in Maghreb and Masriq through two illustrated books. We studied on randomly selected illustrations from Kitab al- Hashaish at-Tibb li-Diskuridus al-Aynzarbi translated by Istefan ibn Basil & Hunayn ibn Ishaq from Dioscorides’ Materia Medica, and Kitab al-Adwiyat al-Mufradat of Abu Ja’far Ahmad al-Ghafiqi, the Andalusian physician, pharmacist, and herbalist. We made comparisons (...) on the illustrations of nine plants and one lichen, chosen from Codex Osler of al-Ghafiqi, and Codices Ayasofya of Istefan-Hunayn, with real photos of plants and lichen, via the methods used currently in the science-art of botanical illustration. With this «botanical illustrative method», we conclude that in the same century, the work of al-Ghafiqi has been copied in a more accurate way than that of Istefan-Hunayn translation. -/- تخصص هذه الدراسة - بعد تقديم معلومات تمهيدية موجزة عن علم أصل الكلمات، وأصول وتطور المعرفة النباتية في الحضارة الإسلامية في العصور الوسطى - للتحليل المقارن للمؤلفات في علم النبات المصور في المغرب والمشرق، من خلال كتابين مصورين. و لهذه الغاية، قمنا بتحليل سلسلة من الرسوم، إختيرت بشكل تلقائي، أُخذت من كتاب النباتات الطبية لصاحبه دِيُسوفُورِيدس، و من ترجمة ابن استيفان ابن باسل و حنين ابن إسحاق لدراسة المادة الطبية لديسوفوريدس، و من كتاب الأدوية البسيطة لأبو جعفر أحمد الغافقي، و هو طبيب و صيدلي و عشاب أندلسي. لقد أجرينا مقارنات لرسوم تسعة نباتات و أشنة وقع الإختيار عليها من كتاب أوسلر للغافقي و من كتب أياصوفيا لإستيفان و حنين، مع صور حقيقية لعينات من هذه الأنواع، باستخدام الطرق المطبقة في وقتنا الراهن في فن وعلم الرسوم النباتية. و بعد تطبيق هذا المنهج التصويري النباتي، نستطيع أن نخلص إلى أنه، و على الرغم من إنتاجها في نفس القرن، فإن نسخ رسوم الغافقي النباتية كانت أكثر دقة من تلك الموجودة في ترجمة استيفان - حنين. الكلمات المفتاحية دِيُسوفُورِيدس، الغافقي، تاريخ علم النبات، الأندلس -/- Este estudio –tras una breve información introductoria sobre etimología, orígenes y evolución del conocimiento botánico en la civilización islámica medieval– está dedicado a un análisis comparativo de los tratados botánicos ilustrados en el Magreb y en el Máshreq, a través de dos libros ilustrados. Para ello, hemos analizado una serie de ilustraciones, elegidas al azar, extraídas del Libro de plantas medicinales de Dioscórides por Anazarba, traducción de Istefan ibn Basil y Hunayn ibn Ishaq del tratado De materia medica de Dioscórides, y del Libro de los medicamentos simples de Abu Ya'far Ahmad al-Gafiqi, médico, farmacéutico y herbolario andalusí. Hemos llevado a cabo comparaciones de las ilustraciones de nueve plantas y un liquen, escogidos del códice Osler de al-Gafiqi y de los códices Ayasofya de Istefan-Hunayn, con fotografías reales de especímenes de dichas especies, acudiendo a los métodos aplicados actualmente en el arte y ciencia de la ilustración botánica. Tras este «método ilustrativo botánico», podemos concluir que, aunque llevadas a cabo en el mismo siglo, las copias de ilustraciones de al-Gafiqi han resultado más precisas que las de la traducción de Istefan-Hunayn. (shrink)

There is not a consensus on the definition of vitality or life yet. Therefore, there are hundreds of definitions and interpretations about life. A number of new or similar definitions have been added in the relevant literature year by year. From this point of view, in this study, it has been examined whether the words canlılık (vitality) and hayat (life) in Turkish can be used as terms equivalent to each other and it has been put forward that it would be (...) more correct to use them separately. The relationship between the parts of an organism’s hierarchy is reviewed, based on the relationships that the cell, as the place where vitality arises, establishes with its similars on the horizontal and with the lineage on the vertical. Based on all of these, a vitality design has been put forward. According to this theoretical design, life has a purpose to continue, and this is possible through an activity of manifestation through the reproduction and diversity of the living beings. It is suggested to use the term homeokinesis instead of homeostasis in order to describe the balance in the living things. Keywords: life, philosophy of biology, relationality, vitality. (shrink)

Objective: Reference values have gained universal acceptance as the most powerful material that helps the decision-making-implementation process of the clinical laboratory. These values ​​may be affected by the geographical location, dietary habits, and other lifestyle changes of individuals applying to the clinical laboratory. Our study aims to determine the reference ranges for the biochemistry test panel, thyroid function tests, and insulin hormone levels, which are frequently needed by clinicians for the province of Gaziantep, with samples obtained from healthy individuals. -/- (...) Materials and Methods: In the study phase, the selection of reference individuals was carried out using the direct method a priori. For the study group, healthy individuals (224 men, 243 women) aged 18-45 were selected. Reference intervals (95% limit) were calculated according to the non-parametric method. -/- Results: When the reference intervals obtained in our study were compared with the reference intervals of the manufacturer, there were differences (> 10% lower or higher) in the upper and lower limits in urea (female and male), creatinine (male), HDL (female), AST (female and male), ALT (female), GGT (female), ALP (common), Lipase (common), CK (male), iron (male), TSH (female and male) markers. Male and female reference intervals for HDL, AST, ALT, and TSH differed significantly. Manufacturer reference ranges for these parameters were common to both sexes. -/- Conclusion: As a result, differences were determined between most of the reference intervals obtained in our study and the reference intervals we routinely use. We think the difference in the reference intervals is due to the differences in dietary habits and environmental factors. (shrink)

The purpose of this study was to determine the attitudes, expectations, experiences, and barriers that physicians in Tripoli hospitals experienced when working alongside Clinical Pharmacists (CPs). A descriptive self-administered questionnaire was used for the study, and participants were selected from several Tripoli hospitals. Most of the respondents agreed that CPs are an essential part of patient care teams and that they have the legal authority to review a patient's medication regimen and response. More than half of respondents believe CPs must (...) be responsible for the medications they prescribe to patients. Half of the respondents agreed that CPs should be encouraged to play a more active role in hospitals and other healthcare facilities. The majority of participants agreed that CPs should participate in managing drug side effects and almost half agreed that CPs can contribute to decisions about drug interactions. By a low agreement rate, 42.7% of respondents thought CPs were specially qualified to counsel patients on drug therapy. A similar low trend was observed, with 40.9% agreeing to provide pharmacists with additional responsibility and authority in clinical departments, in contrast, 54.5% expressed their concern about the clinical responsibility of CPs in clinical practice. A minority of physicians agreed that Physicians should consult pharmacists in selecting the best pharmacological treatment. At the same time, the majority think that pharmacists lack clinical skills and 61.8% feel that physicians are unable to communicate effectively with CPs. 43.6% acknowledged that the traditional opposition between the two professions was a barrier to interprofessional collaboration while the absence of pharmacy space in clinical settings was cited by 39.1%. A majority of respondents agreed that physicians and pharmacists may improve their interprofessional collaboration by raising their awareness about it. A minority of respondents thought that laws and regulations governing physician collaboration should be put in place to promote effective collaboration between physicians and CPs. The study discovered that although most physicians endorse the introduction of clinical pharmacy services in hospitals and believe that physicians and pharmacists can collaborate on many tasks, respondents were not as impressed with the CPs' performance and believed that they lacked the professionalism required to carry out clinical responsibilities successfully. To facilitate the growth of clinical pharmacy services, laws and regulations must be put in place. (shrink)

Lichens are included in the classification system of fungi and have been used in medicine, pharmacy and industry from antiquity to present day in the treatment of various diseases. In this study, Peri Hyles Iatrikes of Dioscorides has been investigated and evaluated from lichenological point of view. It is found that, Dioscorides mentions about medical properties and uses of probable Parmelia species such as P. saxatilis (L.) Ach or P. sulcata Taylor.

The reception of the translations of Aristotelian and pseudo-Aristotelian works at the University of Paris in the thirteenth century promoted a new understanding of the sciences as specialized fields of knowledge. The huge amount of translations required a new organization of knowledge, which included novel subjects and categories. Among these there is a very special case, namely the pseudo-Aristotelian De plantis, translated from Arabic into Latin and then back into Greek to be re-translated into Latin again. De plantis was included (...) in the new curriculum in Ripoll 109, and constituted the main source for botanical studies until the sixteenth century. Throughout this paper we will explore the reception and impact of De plantis in both the Arabic and the Latin traditions. We aim to show its foundational role in the development of botany as a theoretical discipline within the natural sciences. (shrink)

Air pollutants pose a threat to biodiversity throughout the world. This study was conducted to evaluate atmospheric element accumulation in Isparta city, including Gölcük Nature Park, located in the Western Mediterranean Region of Turkey. It is aimed to determine the air quality and potential pollutant sources in the region through lichen biomonitoring. Specimens of the epiphytic foliose lichen Physcia aipolia (Erh. ex Humb.) Fürnr. were sampled from 14 sites in the study area and analyzed by ICP-MS with reference material in (...) order to detect 11 trace elements; Al, As, Cd, Cr, Cu, Fe, Mn, Ni, Pb, V, and Zn. The spatial distribution of these airborne elements in the study area was mapped. The results showed that the elemental sequence in terms of average concentrations measured was as follows: Ni >Cr >V >Fe >As >Al >Zn >Cu> >Cd >Mn >Pb. The results of cluster analyses of the elemental data indicated that the 3 major contaminants in the urban area were Cr, Ni, and V, probably due to the extensive use of coal in heating facilities and gasoline in vehicles. P. aipolia specimens accumulated maximal concentrations of As, Cr, Fe, Ni, and V in the northern and the southeastern localities surrounding the city, while Cd, Pb were most abundant in the eastern edge of Gölcük Nature Park. The pollution in Isparta city with heavy metal is worse than expected, mostly due to the extensive use of coal as fossil fuel. In addition, it seems to be associated with the city's topographic and climatic characteristics, e.g. inversion effects. (shrink)

Bu çalışmada, bitkibilimde kullanılan bir terim olan liken kelimesine, kök anlamına sadık kalarak Türkçe yeni bir karşılık önerilmektedir. Bu önerinin mantıksal çerçevesi, Antik Yunancadan, Orta Çağ Arapçasına, Orta Çağ Latincesine ve nihayetinde de Türkçeye kadar uzanan bir yelpazede, konuya esas teşkil eden tarihî metinlere ve onların kaydedildiği elyazmalarına dayanmaktadır. Türkçe metinlerde liken terimi yerine yalaç teriminin kullanımı öneri lmektedir. Bu öneri ülkemizdeki dilbilim, onomastik ve bitkibilim uzmanlarının eleştirel dikkatine sunulmaktadır.

Abstract: Lotteries have long been a source of fascination and intrigue, offering the tantalizing prospect of unexpected fortunes. In this research paper, we delve into the world of lottery predictions, employing cutting-edge AI techniques to unlock the secrets of lottery outcomes. Our dataset, obtained from Kaggle, comprises historical lottery draws, and our goal is to develop predictive models that can anticipate future winning numbers. This study explores the use of deep learning and time series analysis to achieve this elusive feat. (...) Through rigorous experimentation and data-driven approaches, we seek to determine the viability of AI in the realm of lottery predictions. Our findings reveal both the promise and limitations of AI in this context, shedding light on the complexities of lottery data and the potential need for quantum computing as a last resort. (shrink)

One of the most important thinkers of the twentieth century, Heidegger’s phenomenological investigation of existence, had a notable influence on the world of thought. In this work, two planes that fold over each other and present a holistic structure in Heidegger’s thought have been wended at the same time. The first of these is the investigation of the social possibility of Dasein's aspects, Heidegger's main problematic, through spatial conceptualizations such as space, place, closeness and distance; the second plane is the (...) reframing of Dasein's social aspects in the context of the concepts of 'dwelling' and 'construction'. This discussion also reveals the possibility of interaction between philosophy (ontic/ontological being, metaphysics, Dasein) and sociology (society, coexistence, social) in Heidegger's thought through the concepts of architectural discipline such as space, place, dwelling and building. All in all, it seems that the dwelling Heidegger built for Dasein offers a remarkable proposition to the social aspect of architecture; this points, above all, to the potential of “being with”, of human community, of a new relationship with the world. (shrink)

In 2001 soon after the Asian Crises of 1997-1998, the DotcomBubble, 9/11, the Enron crises triggered a fraud crisis in Wall Street that impacted the market to the core. Since then scandals such as the Lehman Brothers and WorldCom in 2007-2008 and the Great Recession have surpassed it, Enron still remains one of the most important cases of fraudulent accounting. In 2000’s even though the financial industry had become highly regulated, deregulation of the energy industry allowed companies to place bets (...) on future prices. At the peak of the dotcom bubble Enron was named as a star innovator but when the dotcom bubble burst, Enron’s plan to build high speed internet did not flourish and investors started to realize losses. Furthermore, the financial losses of the operations were hid using the market to market accounting technique instead of book value and using special purpose entities to hide debt. The root cause that was identified as a company with a toxic corporate culture focused on officer compensation rather than social responsibility and hence faulty leadership. Is it possible then that; ethical accounting practices, social responsibility and ethics all become inferior goods as income rises in an ‘irrationally exuberant’era? (shrink)

Due to how fast life moves these days, most parents forget to keep an eye on their children’s development and math skills as early as 4 years old. The role of child care is very important to enhance quality assurance practices among staff for the development of future leaders. The main objective of this study is to determine the strength of the relationships between each element and arithmetic proficiency among Malaysian TASKA children. This study is significant to identify the primary (...) factors that influence children’s math skills. A questionnaire was utilized to collect data. From 376 TASKAs registered in Malaysia, only 103 of the 458 selected centers provide care and instruction for children aged 36 to 48 months. Between the ages of 36 and 46 months, language, communication, and early reading skills account for the majority of a child’ s mathematical ability. Therefore, an effective training module should be built on these characteristics. The upcoming study will compare all unregistered TASKA facilities to the facilities that have been registered throughout Malaysia. (shrink)

In recent decades, interest in the history and philosophy of the natural sciences has increased significantly. This interest has made scholars aware of the existing knowledge gap in these areas and has brought a kind of 'pressure' for more articles and books on the subject. Indeed, it also motivates academics to start new projects related to these disciplines. Volumes like this are much needed for scholars in the field, given the high amount of information they contain. This rich volume aims (...) at stimulating the field by presenting current research papers on Avicenna's influence on the fields of physics and cosmology. In order to achieve this goal, this work contains thirteen articles related to the reception of the Persian philosopher's thought in these areas in the Middle Ages. The book revolves around the three different languages and cultures which were crucial for the reception of Avicenna's thought. Hence, the volume is arranged in three main sections focusing on the Arabic, Hebrew and Latin traditions. It also contains an Index of Avicenna's Works with Passages Cited and an Index of Names. The introduction is rather short compared to other sections of the book. It covers the general topics presented in the volume. The first six chapters deal with the Arabic tradition ; the next two have to do with the Hebrew reception of Avicenna, and the last five analyse the Latin reception of Avicenna's physics and cosmology. (shrink)

The debate between natural law and positivist law has been received much attention. Ronald Dworkin exposes the limitation of positivist law through the argument of hard cases. This argument is furthered strengthened when we apply the interpretation of Martin Luther King Jr and the voluntarist natural law tradition, and Lon Fuller’s ‘procedural view’ and the application of the ‘principles of legality’.

Objective: Atlas is located at a critical point close to the vital centers of the medulla oblongata, which can be compressed by the dislocation of the atlantoaxial complex or instability of the atlantooccipital joint. This study aimed to determine in detail the morphometric and morphological characteristics of the atlas to guide the reduction of the risk of complications and increase the success rate in various surgical approaches for the craniovertebral junction. -/- Methods: In this study, 17 atlas vertebrae whose measurement (...) parameters were pronounced and unknown gender, age, and ethnic characteristics were examined. -/- Results: Totally 16 parameters, 11 of which were bilateral and 5 were unilateral, were examined on the atlas. Also, no accessory foramen transversarium was found in these atlas vertebrae. Of the 23 foramina transversaria that were prominent and not broken, 7 were found to be round-shaped (30.43%), and 16 were oval-shaped (69.57%). -/- Conclusion: It is deducted that the results obtained in this study will help to have information about the morphometry and morphology of atlas vertebrae. Although information such as age, gender, and ethnic origin is not known about the bones evaluated, it is the advantage of this study that a large number of parameters are evaluated and compared with previous publications. Nevertheless, it seems that there is a need for studies in which much more cases are assessed, and information such as age, gender, and ethnic origin is known. (shrink)

Background: A bean is the seed of one of several genera of the flowering plant family Fabaceae, which are used as vegetables for human or animal food. They can be cooked in many different ways, including boiling, frying, and baking, and are used in many traditional dishes throughout the world. Beans are one of the longest-cultivated plants. Broad beans, also called fava beans, in their wild state the size of a small fingernail, were gathered in Afghanistan and the Himalayan foothills. (...) In a form improved from naturally occurring types, Beans were an important source of protein throughout old and new world history, and still are today. Objectives: The main goal of this expert system is to get the appropriate diagnosis of disease and the correct treatment. Methods: In this paper, the design of the proposed Expert System was produced to help farmers and those interested in agriculture in diagnosing many of the Bean diseases such as Fusarium wilt, Charcoal rot or ashy stem blight, Bacterial leaf spot and blight, Mung bean yellow mosaic virus, Cercospora leaf spot. The proposed expert system presents an overview of Bean diseases are given, the cause of diseases outlined and the treatment of disease whenever possible is given out. CLIPS Expert System language was used for designing and implementing the proposed expert system. Results: The proposed Bean diseases diagnosis expert system was evaluated by Agricultural experts and some friends interested in agriculture and they were satisfied with its performance. Conclusions: The proposed expert system is very useful for Farmers and those interested in agriculture. (shrink)

Considering that the visual dimension of anatomy cannot be ignored and an anatomy education without the visual part will make a doctor imperfect in their profession, it may be seen that pictorial anatomy books written in previous periods are highly valuable. The purpose of this study is to investigate the spinal nerve anatomy included in the work titled Teşrihü’l-Ebdan min e’t-Tıb written in the XIVth century and compare the information at that period to the information of our time. The nervous (...) system was analyzed under a separate title in the book. Firstly, general information was provided about nerves, and then cranial and spinal nerves were described. The author stated in his work that there are two differences between humans and animals as feeling and movement. He stated that the center for feeling and movement is the brain and all nerves converge in the brain. Although there are insufficient or incorrect information in historical books of medicine, such books are highly valuable as they show the scientific progress. It is apparent that Mansur’s work titled Teşrihü’l-Ebdan min e’t-Tıb has a significant place in the history of anatomy, and its influence was reflected in the following periods. Despite the occasions of insufficient or incorrect information in the piece, we think it contributed to the historical development of anatomy. (shrink)

Abstract: The objective of this study was to evaluate water productivity of alfalfa (Medicago sativa) under centre pivot irrigation system. The experimental works were conducted at three centre pivot irrigation projects (Indian, Arab Authority for Agricultural Investment and Development (AAAID) and Sedonix projects) located at Khartoum State during the period from April 2011 to April 2013. In each project, three irrigation systems were randomly selected for the study treatments. Crop water requirement was obtained using CROPWAT 8 computer model. The parameters (...) tested were Christiansen coefficient of uniformity (Cu%), distribution uniformity (Du%), Scheduling uniformity (Su) and Water productivity (kg/m3). SAS (statistical package) was used to analyze the data. The variations among means were checked by the least significant difference (LSD). The results showed that Cu%, Du%, Su and water productivity significantly affected by the management practices in different irrigated projects. Sedonix project gave the highest values of hydraulic characteristic (Cu 85%, Du 81% and Su 1.23) while AAAID project recorded the lowest values (Cu 74%, Du 70%, Su 1.43). Water productivity significantly increased in Sedonix project (0.45 kg/m3/cut) followed by Indian projects (0.38 kg/m3/cut) and AAAID which ranked the least (0.27 kg/m3/cut). It is concluded that for improvement water productivity; proper technical guidelines for system management, operation and scheduling should be followed. (shrink)

This volume aimed to highlight narrative identities of European cities or city neighbourhoods that have been overlooked, such as mid-sized cities. These cities are neither small towns nor metropolises, cities that are now unveiling their appeal or specificity. The present special issue thus covers a range of representations of cities. The articles investigate more systematically how different texts deal with various cities from different experiential and fictional perspectives. The issue covers the geographical scope across Europe, from east to west or (...) vice versa, as well as a range of different works of national literature(s), but with a clear emphasis on mid-sized European cities that have until now been deemed as lesser-known, secondary, peripheral, ‘other’ cities that are in the focus of the research of the COST project Writing Urban Places. New Narratives of the European City, within which this journal issue is being published. (shrink)

Background: Persimmon is a grassy, perennial plant, belonging to the oral platoon, square-shaped leg, bifurcated, erect, and ranging in height from (10 - 201 cm). Home to Europe and Asia. The Persimmon plant has many benefits, the most important of which are pain relief, treatment of gallbladder disorders, the expulsion of gases, anti-inflammatory, and relaxing nerves. While the Persimmon plant is the ideal option for the start of gardens, it is prone to some common diseases that affect the plant's growth. (...) Objectives: The main goal of this expert system is to get the appropriate diagnosis of disease and the correct treatment. Methods: In this paper, the design of the proposed Expert System was produced to help Farmers and those interested in agriculture in diagnosing many of the Persimmon diseases such as Persimmon rust, Verticillium wilt, Anthracnose, Powdery mildew, Black Stem Rot, Stem and stolon canker, Septoria leaf spot. The proposed expert system presents an overview of Persimmon diseases are given, the cause of diseases outlined and the treatment of disease whenever possible is given out. CLIPS Expert System language was used for designing and implementing the proposed expert system. Results: The proposed Persimmon diseases diagnosis expert system was evaluated by Agricultural Students at AL Azhar University and some friends interested in agriculture and they were satisfied with its performance. Conclusions: The proposed expert system is very useful for Farmers and those interested in agriculture. (shrink)

Objective: to evaluate CANLPH score and systemic immune inflammation index (SII) in patients with symptomatic rheumatic mitral stenosis (MS) undergoing percutaneous mitral balloon valvuloplasty (PMBV). -/- Methods: 62 patients who underwent PMBV in our clinic between 2018 and 2021 were included retrospectively. The patients were divided into 2 groups according to echo score. The CANLPH score was calculated from the cut-off values of C-reactive protein to albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR) and platelet to hemoglobin ratio (PHR), determined (...) with the Youden index and SII by the formula platelet x neutrophil/lymphocyte. P <0.05 was considered statistically significant. -/- Results: The mean age of the patients was 44.5±10.4 years (40 female, 64.5%). The mean values of SII and CANLPH scores were higher in the Echo score >8 group (p <0.001, both). The mean mitral gradient before and after PMBV was 12.6±5.7mm Hg and 5.0±2.4 mm Hg, and the mean valve area was 1.12±0.27 cm2 and 1.85±0.29 cm2. A statistically significant and negative correlation was observed between the gradient decrease after the procedure and the CANLPH score and SII (r=-0.426, p=0.001 and r=-0.418, p=0.001, respectively). In receiver operating characteristic (ROC) curve analysis, it was concluded that the ability of CANPLH score to predict the higher Echo scores was noninferior to SII with an area under curve (AUC:0.820 (0.701-0.906) and AUC:0.786 (0.664-0.880), z statistics 0.576 and p=0.564. -/- Conclusion: SII and CANLPH scores are correlated with Echo score. A significant negative relationship was found with both biomarkers and gradient decrease after the PMBV. (shrink)

Objective: Evaluating study environments, attention–motivation levels while studying, and studying methods of students is ex-tremely important for obtaining purposed results. This study aimed to determine study environments, attention–motivation levels while studying, and studying methods of medicine faculty students. -/- Methods: Gaziantep University School of Medicine students completed the questionnaire that included questions regarding study environments, attention–motivation levels, and studying methods. The students were asked 11 open-ended questions and 29 Likert-type questions. Statistical analyses of these questions were performed, and some of (...) the questions correlated among them. -/- Results: The statistically significant differences were determined between the average grade and questions: “I have difficulty in focusing on the subject before starting to study,” “I easily lose concentration while studying,” “I use some pharmaceuticals (except vitamins) for increasing my motivation while studying,” “I use some pharmaceuticals (except vitamins) for increasing my attention while study,” and “I only study during exams.” A significant association was also observed between the average grade and the accommodation of students. -/- Conclusion: Improving the physical conditions of the study environment of medicine faculty students will contribute to increas-ing their academic success. Making students aware of the components that negatively affect attention and motivation will also positively affect the academic success of students. In addition, determining studying methods of medicine faculty students will contribute to improving personal education strategies. (shrink)

Objective: The measurement of international publication activities is one of the essential indicators used to evaluate the scientific development level of countries. Although many studies are using the bibliometric method in the literature, it is seen that there are very few bibliometric studies in the field of anatomy. This study aimed to analyze the articles bibliometrically which conducted by researchers at institutions from Turkey and indexed in Science Citation Index Expanded (SCI-E) of the Web of Science database in the category (...) of Anatomy and Morphology. Materials and Methods: According to 2019 data, journals in the Anatomy and Morphology category and indexed in the SCI-E were determined. Publications from Turkey that were published in these journals was determined. The full-texts of these articles were examined, and study types were defined. Also, VOSviewer software was used to create a collaboration and word co-occurrence network. Results: It was determined that there were 48,002 publications in 21 journals. It was found that 1,461 publications (3.04%) have at least one author from Turkey. The total number of citations was 11,728 for these publications. The average number of citations was 8.02±11.95. The radiological studies have increased statistically more than both experimental animal and cadaveric studies by years. In addition, it has been determined that the total number of articles, especially the radiological studies, has increased significantly over the years. Conclusion: The increase in the number of scientific studies in the field of anatomy is important in terms of the contribution of Turkey to literature in this area. (shrink)

Introduction: The having extremely detailed macroscopic anatomy knowledge of the present medicine literature has been result of the information accumulation throughout the hundreds years. The numerous science hero have contributed for this purpose. The scientists being ahead of his time by their knowledge and scientific perspective have contributed worthy to development process of medicine. -/- Materials and Methods: The chapters related to the kidney anatomy in El-Kânûn Fi’t-Tıbb was written by İbn-i Sînâ in the 11th century, Kitab-ı Teşrihü’l-Ebdan Min e’t-Tıb (...) is one of the first illustrated anatomy books that was written by Mansur b. Muhammed b. Ahmed in 14th century, Teşrih-ülEbdan ve Tercümânı Kıbale-i Feylesûfan is the first illustrated Turkish anatomy book that was written by Şemseddîn-i İtâkî in 17th century were evaluated. -/- Results: The informations were compared in three books and were interpreted by the present informations. These books have contributed to development of anatomy although some of the informations in them are faulted. -/- Conclusion: All three books are valuable in point of showing the development of medicine. The extensive evaluation of books which have important place in history of medicine will give valuable information about development process of medicine. (shrink)

Abstract: The intelligent embedded agricultural robotic system is a low cost and efficient microcontroller robot which include; A soil moisture monitoring system which monitors the moisture content of the soil in the various parts of the field and the measured data to a microcontroller unit which in turn displays the received data on a Liquid Crystal Display to determine when to irrigate or spray the farm field. An automatic car, which follows a path designed in the field, i.e., a white (...) line on a black surface integrated with a spraying and irrigating mechanism for carrying out agricultural spray and irrigation. An automatic solar tracking system that tracks the sun’s position for maximum light intensity was used to charge the DC 12V battery which was used to power to the robotic system. A refilling system with obstacle detection feature was used for refilling water, chemical or fertilizer spray in the spraying and irrigating tank integrated with the line follower robotic system. This embedded system is useful for farmers who wish to monitor the soil moisture content of the field, and automate spraying and irrigation purposes at low costs and higher efficiency. (shrink)

Son dönemde yapılan araştırmalarda en mutlu şehir olarak seçilen Sinop’un yüzyıllar öncesinde bir sakini vardı ki insanlık için mutlu olmanın doğru yolunu bulmayı kendine dert edinmişti. Öğretileri Roma İmparatorluğu’nun resmi dini gibi benimsenecek, Marcus Aurelius gibi Roma Krallarının filozofu olmaktan gurur duyacağı Stoa Okulunun ve Dünya Hükümdarı Büyük İskender’in büyük övgüsüne mazhar olmuş, Sinoplu Diogenes.

Translated into Turkish by Mustafa Yalçınkaya.