Molecular developmental biology has expanded our conceptions of gene actions, underpinning that embryonic development is not only governed by a set of specific genes, but as much by space–time conditions of its developing modules. Typically, formation of cellular spheres, their transformation into planar epithelia, followed by tube formations and laminations are modular steps leading to the development of nervous tissues. Thereby, actions of organising centres, morphogenetic movements, inductive events between epithelia, tissue polarity reversal, widening of epithelia, and all these occurring (...) orderly in space and time, are driving forces of emergent laminar neural tissues, e.g. the vertebrate retina. Analyses of self-organisational formation of retina-like 3D structures from dispersed cells under defined cell culture conditions demonstrate that not only particular genetic networks, but—at least as important—the applied culture conditions define phenotypes of emergent tissues. Such in vitro approaches allow assigning emerging tissue formation to ground-laying genetic networks separately from contributions by conditional constraints. (shrink)

Das letzte halbe Jahrhundert hat einen unvergleichlichen Siegeszug der Molekularbiologie erlebt, zu dem die Genomik, die molekulare Zell- und Entwicklungsbiologie, die Epigenetik sowie Erkenntnisse der Stammzellbiologie als tragende Säulen beigetragen und die Biowissenschaften insgesamt in die sogenannte postgenomische Ära geführt haben. Anstelle eines verengten Blicks in den Kern der Zelle und seiner DNA hat sich das Visier von Biologen auf eine sich dynamisch verändernde Zellumgebung hin geöffnet. Wechselwirkungen zwischen molekularen, zellulären, organismischen bis hin zu ökologischen Hierarchieebenen, stets aufwärts und abwärts (...) interagierend (bottom-up und top-down), bestimmen das Bild postgenomischer Naturbetrachtung. Dieses erweiterte Gesichtsfeld führte einerseits weg von einem strikten Gen-gesteuerten Determinismus hin zu Systemdenken und zur Systembiologie. Zum anderen rückten auf diesem Weg wieder Lücken in der klassischen neodarwinistischen Lehre in den Fokus, die nach einer erweiterten Synthese der Standardlehre der Evolution rufen. So hat das neue Forschungsfeld Evo-Devo (Akronym für Evolutionary Developmental Biology) erstmals molekulare Mechanismen für die sprunghafte Entstehung von Merkmalen aufgezeigt, die die Grundlage für die Entstehung neuer Baupläne (Makroevolution) bildeten. (shrink)

Die Frage nach der Vererbung von Eigenschaften bei Lebewesen beschäftigt den Menschen seit alters her: das ist Genetik. Auch lange schon beschäftigen sich Biologen mit der Frage, wie sich die vielen Tierarten im Laufe einer langen Stammesgeschichte herausbilden konnten: das ist Evolution. Wie wird Konstantes über Generationen bewahrt und Diverses/Neues eingeführt? Die überragenden Erfolge der Genetik haben uns im Glauben eingelullt, wir hätten diese Prozesse vollständig verstanden. Mit dem Aufkommen der so genannten Epigenetik kommen Grundlagen sowohl der Individual-, wie auch (...) der Stammesentwicklung jedoch wieder ins Schwanken. In diesem Artikel will ich einen kleinen Einblick in das Feld der Epigenetik und ihre gesellschaftliche Relevanz geben. (shrink)

Nach neodarwinistischem Verständnis der Evolution entstehen neue Organismen letztlich durch rein zufällige Mutationsprozesse auf genetischer Ebene. Ihre Überlebenschancen werden dann durch die jeweilig herrschende Umwelt begünstigt oder unterdrückt. Die Evolution ist demnach nur vom reinen Zufall geleitet. Neuere Einsichten aus Entwicklungsbiologie (EvoDevo) und Epigenetik haben unsere Sicht der Evolutionsabläufe jedoch deutlich erweitert. Dabei kommt der Umwelt eine lenkende Rolle zu, der reine Zufall verliert an Bedeutung. Damit lässt sich naturwissenschaftliches Verständnis wieder besser mit herkömmlichen Schöpfungsbildern versöhnen.

Seit der Aufklärung versucht der Mensch, Gott abzuschaffen. Dabei fällt der Zufälligkeit, und damit auch der Ziellosigkeit in der darwinistischen Sicht der Evolution besonderes Gewicht zu. Diese weithin akzeptierten Dogmen stehen diametral gegen jahrtausendealte Vorstellungen, die letztlich in allen Kulturen und Religionen hervorgebracht wurden, daß die Natur eine Schöpfung Gottes sei, in der der Mensch das höchste, Gott-ebenbildliche Wesen sei. Nach Erkenntnissen der klassischen Genetik schienen Gene an die Stelle von Gott getreten zu sein: sie haben absolute Gewalt und beherrschen (...) die belebte Natur. Sie haben je einen eindeutigen Befehl, sind unbeugsam und gerecht, wie Gott im AT. Das Produkt Mensch ist nur einer ihrer zahllosen Spielbälle, existiert vorübergehend, ein Zigeuner in einer verlassenen Ecke des Kosmos (Monod, 1992). Diese neodarwinistische Sicht, die nicht zuletzt zum Niedergang der Kirchen bei uns beiträgt, wird von neuen Erkenntnissen der Entwicklungsbiologie (EvoDevo) infrage gestellt. (shrink)

Der erste Teil dieses Aufsatzes befasst sich mit der Tatsache, dass neben der Stammesgeschichte des Menschen (Phylogenese) und seiner je individuellen genetischen Ausstattung für seine Persönlichkeitsentwicklung besonders wichtig ist, dass sein Gehirn bei der Geburt noch unausgereift ist. In dieser Phase kommen Umwelteinflüsse (Lernen jeglicher Art) besonders stark zum Tragen, so daß die „Freiheit des Menschen“ hier wesentlich begründet wird. Soviel uns das Studium der Frühentwicklung des Gehirns (Ontogenese) über seine Organisation und seine Funktionen hat verstehen lassen, bleibt doch fraglich, (...) inwieweit die Hirnforschung uns in Fragen nach den seelisch-geistigen Fähigkeiten des Menschen, oder gar nach Gott und Gottesbildern weiterbringen kann. Im 2. Teil wird daher am Beispiel der Hirnfunktionen und der Frage nach dem Bewusstsein erläutert, warum menschliche Erkenntnisfähigkeit begrenzt ist. Die Naturwissenschaft behandelt Wenn-Dann-Fragen und liefert Gründe für das Dann. Sie kann jedoch weder Wesensfragen klären, noch den letzten Urgrund alles Seienden festmachen. Weil aber alles einen Grund haben muß, kann es ein absolutes Nichts niemals gegeben haben, oder geben. Daraus folgend wird im 3. Teil erläutert, dass es gerade rational Sinn macht, als Urgrund der Welt eine letzte Allmacht, also Gott zu denken. Religion kann demnach als höchste, weil freiheitlichste und damit menschlichste Leistung unseres Hirns verstanden werden. Die Evolution hat mit dem menschlichen Gehirn nicht nur die Stufe der Selbst-, sondern auch der Gottesreflexion erreicht. Dies könnte biologisch mit dem theologischen Begriff der Gottesebenbildlichkeit gemeint sein. (shrink)

Physiologie und Struktur komplexer Gehirne lassen sich durch Betrachtung evolutions- und entwicklungsbiologischer Abläufe analysieren, was der Hirnforschung tiefe Einblicke bis zur molekularen Ebene erlaubt. In knappster Form werden grundlegende Aspekte der Stammes- und Individualentwicklung (Phylo- und Ontogenese) von Gehirnen im Tierreich beschrieben, bis hin zum menschlichen Gehirn, dessen Grobgliederung skizziert wird. Das Lernvermögen insbesondere von Kleinkindern ist aufgrund postnataler Hirnplastizität erklärbar. Systematische Unterschiede zwischen einzelnen Zellen und Neuronenverbänden sind für selbstorganisierende Bewußtseinsprozesse bedeutsam. Am Beispiel der stufenweisen visuellen Signalverarbeitung wird die (...) mögliche Wahrnehmung von Bildern diskutiert, um danach gängige Theorien zur Bewußtseinsfrage einander gegenüber zu stellen. Schließlich wird auf das Qualia-Problem eingegangen, was vom Autor als Unerklärbarkeit des Bewußtseinsinhalts und als Urfrage des Leib-Seele-Problems verstanden wird. Sie kann wohl auch durch modernste biologische Forschung nicht beantwortet werden. (shrink)

Berge von brennenden Tieren, Bilder vom „Keulen“, Bilder vom geklonten Menschen. Aber auch Euphorisches: nach der Aufklärung des menschlichen Genoms schöpfen Krebs- und AIDS-Kranke, Querschnittsgelähmte und Alzheimer-Patienten neue Hoffnung. Bilder auch von Börsenkursen: vom neuen Markt der Informations- und Biotechnologien hängt unsere ökonomische Zukunft ab. Hinter allem stecken die „Life Sciences“, und oft wird man mit schrägem Blick gefragt, was das für Leute sind, diese Bio- bzw. Lebenswissenschaftler? Die Frage nach den Möglichkeiten und dem wahren Wert des biomedizinischen Fortschritts, nach (...) seiner Kontrolle, nach seiner Verantwortung, nach seiner gesellschaftlichen Bindung wird lauter. (shrink)

Bei der Suche nach dem rätselhaften Ursprung des Phänomens „Leben“ wird hier zunächst die zelluläre Ebene betrachtet. Im Grundaufbau zeigen alle Zellen viel Konstantes, aber gleichzeitig stellt jede Zelle ein einmaliges Individuum dar. Leben von Zellen gibt es nur als gegenseitiges Wechselspiel mit ihrer jeweiligen Umwelt. Das Genom (die Gesamtheit aller Gene) bleibt ab der Befruchtung in jeder Zelle eines Individuums konstant. Aber auch die Verwirklichung der Gene braucht eine „molekulare Umwelt“, besonders die vom Muttertier vorbereitete Umwelt im Zytoplasma des (...) Eies. Individualität eines Organismus (z.B. des Menschen) wird also nicht allein vom Genom festgelegt, sondern ist durch Entwicklungsprozesse bedingt (braucht Zeit!). „Leben“ kann (muß?) somit begriffen werden als ein wechselseitiges Kontinuum, welches alle Individuen, alle Spezies und alle Generationen miteinander und ihren Umwelten verbindet. Wie phylogenetisch betrachtet die allererste Zelle aus abiotischen Umständen entstehen konnte, wird hier nicht behandelt. Das Gesagte legt allerdings nahe, dass es nicht Gene waren, die sich eine belebte Welt erschufen, sondern bestimmte (Um-)Welten „erschufen“ sich Gene, die „lebenstauglich“ waren. (shrink)

Never was dogmatic reductionism helpful in conceiving the phenomenon of life. The post-genomic era has made it clear that genes alone cannot explain the functioning of whole organisms. Already each cell represents a unique, non-recurring individual. Recent progress in developmental biology has conveyed new perspectives both on the makings of individual organisms (ontogeny), as on evolutionary change (Evo-Devo). The genome (the entirety of all genes) of an animal remains constant from fertilization onwards in each cell. The realization of genes requires (...) molecular environments, in particular pertinent to the cytoplasm of the unfertilized egg. Individuality of an organism therefore is not only determined by its genome, but is shaped through developmental processes (it needs time!). Organisms can only exist through mutual interplays with their respective (molecular and cellular) environments at all levels of organization. Thus, life can be conceived of as endless networks of communication, e.g. as a mutual continuum, connecting all individuals, all species and all generations within their given environments. Evolutionarily, nature does not select fitting genes, but rather viable traits. The presented concepts render it unlikely that it was genes that founded our living world, but rather that distinct environments shaped “genes” (of whatever chemical nature) which proved to be “life-suitable”. (shrink)

Darwin´s Erkenntnis über die Abstammung der Arten durch Mutation und Selektion sind in aller Munde, dass aber darüber im Detail noch viel Unklarheit herrscht, ist weniger bekannt. Es sind Fortschritte der Entwicklungsbiologie, die erst seit wenigen Jahren uns molekulare Erklärungsmuster an die Hand geben, mit denen die Entstehung neuer Arten besser verständlich wird. Es handelt sich um die Aufklärung der Wirkungsweise von Genen und ihren molekularen Produkten, die während der embryonalen Entwicklung von Tier und Mensch dafür sorgen, daß der Organismus (...) sich normal entwickelt. Treten Veränderungen (Mutationen) in einem dieser Mastergene auf, so wird dies zur Missbildung oder gar zum Absterben des betreffenden Embryos führen. Aber in seltenen Fällen kann so auch eine neue Tierart begründet werden. Gerade im Darwin-Jahr werden die Lehrbücher zur Evolutionsbiologie um ein wesentliches Kapitel erweitert. Es ist mit EvoDevo überschrieben und will damit ausdrücken, daß Evolutionary Theory ohne Developmental Biology keinen Sinn macht. Die bisherigen Lücken im Verständnis des Evolutionsgeschehens und die neue Sicht von EvoDevo wird im Folgenden dargestellt werden. (shrink)

Anlaß zum vorliegenden Artikel gab eine Tagung zum Thema „Gott-Geist-Gehirn“, bei der im Dialog zwischen Theologen und Neurowissenschaftlern Beziehungen zwischen diesen drei Begriffen diskutiert wurden. Aus biologischer Sicht sind es vor allem Hirnleistungen, welche uns spezifisch zum Menschen machen. Die Entstehung der Hirnstrukturen während der Embryonal- und Postnatalperiode wird im ersten Teil behandelt, deren Verständnis essentiell ist. Im zweiten Teil werden physiologische Fähigkeiten des menschlichen Gehirns am Beispiel des visuellen Systems in sehr verkürzter Weise dargestellt, um zu untersuchen, inwieweit physiologische (...) Erkenntnisse das Phänomen der Wahrnehmung bis hin zur Entstehung von Bewusstsein erklären können. Weil sich hier Verständnislücken auftun, die nach meinem Dafürhalten grundsätzlich und unlösbar sind (Qualia-Problem), komme ich schließlich zur Unvollständigkeit jeglicher naturwissenschaftlichen Weltsicht (unendliche Regresse) und die damit notwendige Annahme einer „Ur-Ursache“ dieser Welt, wie sie schon von Aristoteles im kosmologischen Gottesbeweis formuliert wurde. So führt diese Betrachtung zum Schluß, dass insbesondere Naturwissenschaftler einer Ur-Ursache bedürften (Gottesbedürftigkeit). (shrink)

Nicht Stabilität, sondern Instabilität sei der Grundcharakter der Natur, so hören wir von Jan Schmidt als Auftakt zu seinem Buch „Das Andere der Natur“ (Hirzel-Verlag, 2015). „Das Eine der Natur“, welches reduktionistisch zu erfassen ist, soll durch ein „Anderes“ ergänzt werden. Von dieser anderen Seite her zeigt sich „Natur ... auch (als) instabil, komplex, chaotisch, zufällig, emergent...“, und aus dieser Sicht des Naturgeschehens heraus will der Autor eine Philosophie der Instabilität entwerfen. Der gelernte Physiker und Philosoph lehrt an der Hochschule (...) Darmstadt (hda) Wissenschafts- und Technikphilosophie. Sein Buch beleuchtet das Thema „Instabilitäten“ aus vielen Blickwinkeln. Was sind Instabilitäten, was Selbstorganisation, was ist Zeit, was Zufall, was Kausalität? Diese Erkenntnisse bezieht der Autor dann auf den Kosmos, auf die Evolution bis hin zum menschlichen Gehirn und seinen Leistungen. Mit dieser Rezension gehe ich ausführlich auf dieses lesenswerte Buch ein. (shrink)

The role of acetylcholinesterase (AChE) in neurotransmission is well known. But long before synapses are formed in vertebrates, AChE is expressed in young postmitotic neuroblasts that are about to extend the first long tracts. AChE histochemistry can thus be used to map primary steps of brain differentiation. Preceding an possibly inducing AChE in avian brains, the closely related butyrylcholinesterase (BChE) spatially fore-shadows AChE-positive cell areas and the course of their axons. In particular, before spinal motor axons grow, their corresponding rostral (...) sclerotomes and myotomes express BChE, and both their neuronal source and myotomal target cells express AChE. Since axon growth has been found inhibited by acetylcholine, it is postulated that both cholinetsreases can attract neurite growth cones by neutralizing the inhibitor. Thus, the early expression of both cholinesterases that is at least partially independent from classical cholinergic synaptogenesis, sheds new light on the developmental and medical significance of these enzymes. (shrink)

Der Kugel als Grundbauform des Lebens begegnen wir im gesamten Organismenreich, angefangen von sphärischen einzelligen Lebewesen wie der Namibperle (Thiomargaritha namibiensis), einem großen marinen Bakterium, über kugelige, vielzellige Algen wie der Süßwasseralge Volvox, marinen Rippenquallen wie der Seestachelbeere (Pleurobrachia) und den frühen Entwicklungsstadien tierischer Vielzeller (Metazoa). Alle diese kugeligen Gestalten finden wir fast ausschließlich in wässrigem Milieu. An Land sind die Pflanzen hingegen generell langgestreckt. Tiere haben spätestens beim Auszug aus einer aquatischen Umgebung die Kugelform aufgegeben. Diese Beobachtung führt zur (...) Frage nach den grundlegenden Prinzipien der Bauplanevolution im Zusammenhang mit dem Landgang der Tiere und Pflanzen. Beim Landgang konnte auf bereits im aquatischen Milieu entwickelte Grundformen zurückgriffen werden. Bei den Pflanzen waren es die von Algen bekannten Zellfäden, aus denen die bipolare Langform hervorging. Mit dem einen Ende dem mineralischen Untergrund verhaftet und mit dem anderen in die Atmosphäre reichend, schufen sie die Grundlagen für terrestrische Tiere. Der Schritt ans Land vollzog sich bei Tieren mehrfach und ging von einer größeren Zahl von Bauplänen aus. Wie die evolutionäre Entwicklungsbiologie (EvoDevo) nahelegt, gingen diese auf kleine Abwandlungen in der Embryonalentwicklung zurück, die in kurzen Zeiträumen große Entwicklungsschritte (Makrosprünge) möglich machen. Entsprechend rasch konnten sich die Tiere auch an terrestrische Bedingungen anpassen. (shrink)

Social epistemology should be truth-centred, argues Goldman. Social epistemology should capture the ‘logic of everyday practices’ and describe socially ‘situated’ reasoning, says Fuller. Starting from Goldman’s vision of epistemology, this paper aims to argue for Fuller’s contention. Social epistemology cannot focus solely on the truth because the truth can be got in lucky ways. The same too could be said for reliability. Adding a second layer of epistemic evaluation helps only insofar as the reasons thus specified are appropriately connected (...) to reliability. These claims are first made in abstract, and then developed with regard to our practice of trusting testimony, where an epistemological investigation into the grounds of reliability must inevitably detail the ‘logic of everyday practices’. (shrink)

English - language Wikipedia is constantly being plagued by vandalistic contributions on a massive scale. In order to fight them its volunteer contributors deploy an array of software tools and autonomous bots. After an analysis of their functioning and the ‘ coactivity ’ in use between humans and bots, this research ‘ discloses ’ the moral issues that emerge from the combined patrolling by humans and bots. Administrators provide the stronger tools only to trusted users, thereby creating a new hierarchical (...) layer. Further, surveillance exhibits several troubling features : questionable profiling practices, the use of the controversial measure of reputation, ‘ oversurveillance ’ where quantity trumps quality, and a prospective loss of the required moral skills whenever bots take over from humans. The most troubling aspect, though, is that Wikipedia has become a Janus - faced institution. One face is the basic platform of MediaWiki software, transparent to all. Its other face is the anti - vandalism system, which, in contrast, is opaque to the average user, in particular as a result of the algorithms and neural networks in use. Finally it is argued that this secrecy impedes a much needed discussion to unfold ; a discussion that should focus on a ‘ rebalancing ’ of the anti - vandalism system and the development of more ethical information practices towards contributors. (shrink)

In his 1968 poetry collection „Fadensonnen“, Paul Celan offers a hermetic blend of existentialism and mysticism, which is unusual in two respects. Firstly, the European philosophy of existence, especially with its proponents Jean-Paul Sartre, Albert Camus and Martin Heidegger, had gone to great lengths to criticize and delegitimize the Abrahametic religions, for the concept of god seemed to be an obstacle to humanity in pursuit of its own humanization. Secondly, in the aftermath of the holocaust, the idea of (...) man wanting to merge with a god that had not prevented this cruelty from happening had lost much of its plausibility. Despite these two objections, Celan's poems address the struggle of togetherness in a world that negates the mere possibility of otherness, trying to salvage the unique identity and dignity of the other. With this in mind, the modus operandi of his poems is that of a butcher: Whatever has previously been alive – before the Shoah – now has to be stripped bare of its layers of individual and collective history, has to become less than body and flesh. In this way, the poems' inherent pain and misery transform the reader into a nobody, for only a nobody has got the prerequisites to encounter other people unbiasedly in their unique wholeness. Within this space of encounter, only the reminiscence of body and sexuality exists, commemorating the other, so that radical corporeality seems to be the prerequisite for togetherness. In this ahistorical sphere there is no room for a god that permitted the holocaust, redefining mysticism as the connection between men instead of one between man and god. Celan's poems act as a catalyst, for they exclude god from the spheres of man, making poetry a memorial site to the dead and the ones living in pain. This way, the poems are trying to save Eros (in the sense of creaturely love) from being mutilated by the crimes of European history while at the same time aiming at rehabilitating mankind in a post-holocaust world. (shrink)

In this article it is argued that the optical metaphor and critical practice of diffraction further developed by Donna Haraway and Karen Barad might be no less significant than the widely spread notion of reflection, when the questions of various practices of knowledge are addressed. By considering Paul Ramsden’s approach to learning/teaching and its underlying theory in higher education alongside Karen Barad’s methodology of diffraction, it is shown that Ramsden’s understanding of learning/teaching is rather based on the theoretical assumptions (...) of diffractive practice. His notion that teaching/learning are closely related and actively shaping each other, and that learners are not disconnected from the environment and their previous experiences with the subject matter and learning process itself, adds to Barad’s onto-epistemological position that knowers know the world at the same time as being the part of the world in its ongoing intra-activity. Ramsden’s understanding of relation is diffractive, because it is not about predefined binary entities and their fixed identities, but about layers and entanglements of various previous experiences and reactions to the learning environment. In addition, looking at learning/teaching processes through a different perspective also leads to a different approach to teaching and other ways of problem-solving. Both Ramsden and Barad distrust homologies, analogies, and causality-based conceptions of knowledge sharing. Instead, the ability to respond to an always new learning/teaching environment is assessed, which implies a diffractive type of sensitivity to the context, iterative process of re-turning, and the creation of dangerously indeterminate relationships and commitments. In this way, some of Barad’s philosophical notions, i.e., the diffraction pattern, intra-activity, returning, and others, also may acquire new practical content. (shrink)

continent. 1.1 : 3-13. / 0/ – Introduction I want to propose, as a trajectory into the philosophically weird, an absurd theoretical claim and pursue it, or perhaps more accurately, construct it as I point to it, collecting the ground work behind me like the Perpetual Train from China Mieville's Iron Council which puts down track as it moves reclaiming it along the way. The strange trajectory is the following: Kant's critical philosophy and much of continental philosophy which has followed, (...) has been a defense against horror and madness. Kant's prohibition on speculative metaphysics such as dogmatic metaphysics and transcendental realism, on thinking beyond the imposition of transcendental and moral constraints, has been challenged by numerous figures proceeding him. One of the more interesting critiques of Kant comes from the mad black Deleuzianism of Nick Land stating, “Kant’s critical philosophy is the most elaborate fit of panic in the history of the Earth.” And while Alain Badiou would certainly be opposed to the libidinal investments of Land's Deleuzo-Guattarian thought, he is likewise critical of Kant's normative thought-bureaucracies: Kant is the one author for whom I cannot feel any kinship. Everything in him exasperates me, above all his legalism—always asking Quid Juris? Or ‘Haven’t you crossed the limit?’—combined, as in today’s United States, with a religiosity that is all the more dismal in that it is both omnipresent and vague. The critical machinery he set up has enduringly poisoned philosophy, while giving great succour to the academy, which loves nothing more than to rap the knuckles of the overambitious [….] That is how I understand the truth of Monique David-Menard’s reflections on the properly psychotic origins of Kantianism. I am persuaded that the whole of the critical enterprise is set up to to shield against the tempting symptom represented by the seer Swedenborg, or against ‘diseases of the head’, as Kant puts it. An entire nexus of the limits of reason and philosophy are set up here, namely that the critical philosophy not only defends thought from madness, philosophy from madness, and philosophy from itself, but that philosophy following the advent of the critical enterprise philosophy becomes auto-vampiric; feeding on itself to support the academy. Following Francois Laruelle's non-philosophical indictment of philosophy, we could go one step further and say that philosophy operates on the material of what is philosophizable and not the material of the external world. [1] Beyond this, the Kantian scheme of nestling human thinking between our limited empirical powers and transcendental guarantees of categorical coherence, forms of thinking which stretch beyond either appear illegitimate, thereby liquefying both pre-critical metaphysics and the ravings of the mad in the same critical acid. In rejecting the Kantian apparatus we are left with two entities – an unsure relation of thought to reality where thought is susceptible to internal and external breakdown and a reality with an uncertain sense of stability. These two strands will be pursued, against the sane-seal of post-Kantian philosophy by engaging the work of weird fiction authors H.P. Lovecraft and Thomas Ligotti. The absolute inhumanism of the formers universe will be used to describe a Shoggothic Materialism while the dream worlds of the latter will articulate the mad speculation of a Ventriloquil Idealism. But first we must address the relation of philosophy to madness as well as philosophy to weird fiction. /1/ – Philosophy and Madness There is nothing that the madness of men invents which is not either nature made manifest or nature restored. Michel Foucault. Madness and Civilization. The moment I doubt whether an event that I recall actually took place, I bring the suspicion of madness upon myself: unless I am uncertain as to whether it was not a mere dream. Arthur Schopenhauer. The World as Will and Idea, Vol. 3. Madness is commonly thought of as moving through several well known cultural-historical shifts from madness as a demonic or otherwise theological force, to rationalization, to medicalization psychiatric and otherwise. Foucault's Madness and Civilization is well known for orientating madness as a form of exclusionary social control which operated by demarcating madness from reason. Yet Foucault points to the possibility of madness as the necessity of nature at least prior to the crushing weight of the church. Kant’s philosophy as a response to madness is grounded by his humanizing of madness itself. As Adrian Johnston points out in the early pages of Time Driven pre-Kantian madness meant humans were seized by demonic or angelic forces whereas Kantian madness became one of being too human. Madness becomes internalized, the external demonic forces become flaws of the individual mind. Foucault argues that, while madness is de-demonized it is also dehumanized during the Renaissance, as madmen become creatures neither diabolic nor totally human reduced to the zero degree of humanity. It is immediately clear why for Kant, speculative metaphysics must be curbed – with the problem of internal madness and without the external safeguards of transcendental conditions, there is nothing to formally separate the speculative capacities for metaphysical diagnosis from the mad ramblings of the insane mind – both equally fall outside the realm of practicality and quotidian experience. David-Menard's work is particularly useful in diagnosing the relation of thought and madness in Kant's texts. David-Menard argues that in Kant's relatively unknown “An Essay on the Maladies of the Mind” as well as his later discussion of the Seer of Swedenborg, that Kant formulates madness primarily in terms of sensory upheaval or other hallucinatory theaters. She writes: “madness is an organization of thought. It is made possible by the ambiguity of the normal relation between the imaginary and the perceived, whether this pertains to the order of sensation or to the relations between our ideas” Kant's fascination with the Seer forces Kant between the pincers of “aesthetic reconciliation” – namely melancholic withdrawal – and “a philosophical invention” – namely the critical project. Deleuze and Guattari's schizoanalysis is a combination and reversal of Kant's split, where an aesthetic over engagement with the world entails prolific conceptual invention. Their embrace of madness, however, is of course itself conceptual despite all their rhizomatic maneuvers. Though they move with the energy of madness, Deleuze and Guattari save the capacity of thought from the fangs of insanity by imbuing materiality itself with the capacity for thought. Or, as Ray Brassier puts it, “Deleuze insists, it is necessary to absolutize the immanence of this world in such a way as to dissolve the transcendent disjunction between things as we know them and as they are in themselves”. That is, whereas Kant relied on the faculty of judgment to divide representation from objectivity Deleuze attempts to flatten the whole economy beneath the juggernaut of ontological univocity. Speculation, as a particularly useful form of madness, might fall close to Deleuze and Guattari’s shaping of philosophy into a concept producing machine but is different in that it is potentially self destructive – less reliant on the stability of its own concepts and more adherent to exposing a particular horrifying swath of reality. Speculative madness is always a potential disaster in that it acknowledges little more than its own speculative power with the hope that the gibbering of at least a handful of hysterical brains will be useful. Pre-critical metaphysics amounts to madness, though this may be because the world itself is mad while new attempts at speculative metaphysics, at post-Kantian pre-critical metaphysics, are well aware of our own madness. Without the sobriety of the principle of sufficient reason we have a world of neon madness: “we would have to conceive what our life would be if all the movements of the earth, all the noises of the earth, all the smells, the tastes, all the light – of the earth and elsewhere, came to us in a moment, in an instant – like an atrocious screaming tumult of things”. Speculative thought may be participatory in the screaming tumult of the world or, worse yet, may produce its spectral double. Against theology or reason or simply commonsense, the speculative becomes heretical. Speculation, as the cognitive extension of the horrorific sublime should be met with melancholic detachment. Whereas Kant's theoretical invention, or productivity of thought, is self -sabotaging, since the advent of the critical project is a productivity of thought which then delimits the engine of thought at large either in dogmatic gestures or non-systematizable empirical wondrousness. The former is celebrated by the fiction of Thomas Ligotti whereas the latter is espoused by the tales of H.P. Lovecraft. /2/ – Weird Fiction and Philosophy. Supernatural horror, in all its eerie constructions, enables a reader to taste treats inconsistent with his personal welfare. Thomas Ligotti Songs of a Dead Dreamer. I choose weird stories because they suit my inclination best—one of my strongest and most persistent wishes being to achieve,momentarily, the illusion of some strange suspension or violation of the galling limitations of time, space, and natural law which forever imprison us and frustrate our curiosity about the infinite cosmic spaces beyond the radius of our sight and analysis H.P. Lovecraft. “Notes on Writing Weird Fiction” Lovecraft states that his creation of a story is to suspend natural law yet, at the same time, he indexes the tenuousness of such laws, suggesting the vast possibilities of the cosmic. The tension that Lovecraft sets up between his own fictions and the universe or nature is reproduced within his fictions in the common theme of the unreliable narrator; unreliable precisely because they are either mad or what they have witnessed questions the bounds of material reality. In “The Call of Cthulhu” Lovecraft writes: The most merciful thing in the world, I think, is the inability of the human mind to correlate all its contents. We live on a placid island of ignorance in the midst of black seas of infinity, and it was not meant that we should voyage far. The sciences, each straining in its own direction, have hitherto harmed us little; but some day the piecing together of dissociated knowledge will open up such terrifying vistas of reality, and of our frightful position therein, that we shall either go mad from the revelation or flee from the deadly light into the peace and safety of a new dark age. Despite Lovecraft's invocations of illusion, he is not claiming that his fantastic creations such as the Old Ones are supernatural but, following Joshi, are only ever supernormal. One can immediately see that instead of nullifying realism Lovecraft in fact opens up the real to an unbearable degree. In various letters and non-fictional statements Lovecraft espoused strictly materialist tenets, ones which he borrowed from Hugh Elliot namely the uniformity of law, the denial of teleology and the denial of non-material existence. Lovecraft seeks to explore the possibilities of such a universe by piling horror upon horror until the fragile brain which attempts to grasp it fractures. This may be why philosophy has largely ignored weird fiction – while Deleuze and Guattari mark the turn towards weird fiction and Lovecraft in particular, with the precursors to speculative realism as well as contemporary related thinkers have begun to view Lovecraft as making philosophical contributions. Lovecraft's own relation to philosophy is largely critical while celebrating Nietzsche and Schopenhauer. This relationship of Lovecraft to philosophy and philosophy to Lovecraft is coupled with Lovecraft's habit of mercilessly destroying the philosopher and the figure of the academic more generally in his work, a destruction which is both an epistemological destruction and an ontological destruction. Thomas Ligotti's weird fiction which he has designated as a kind of “confrontational escapism” might be best described in the following quote from one of his shortstories, “The human phenomenon is but the sum of densely coiled layers of illusion each of which winds itself on the supreme insanity. That there are persons of any kind when all there can be is mindless mirrors laughing and screaming as they parade about in an endless dream”. Whereas Lovecraft's weirdness draws predominantly from the abyssal depths of the uncharted universe, Ligotti's existential horror focuses on the awful proliferation of meaningless surfaces that is, the banal and every day function of representation. In an interview, Ligotti states: We don't even know what the world is like except through our sense organs, which are provably inadequate. It's no less the case with our brains. Our whole lives are motored along by forces we cannot know and perceptions that are faulty. We sometimes hear people say that they're not feeling themselves. Well, who or what do they feel like then? This is not to say that Ligotti sees nothing beneath the surface but that there is only darkness or blackness behind it, whether that surface is on the cosmological level or the personal. By addressing the implicit and explicit philosophical issues in Ligotti's work we will see that his nightmarish take on reality is a form of malevolent idealism, an idealism which is grounded in a real, albeit dark and obscure materiality. If Ligotti's horrors ultimately circle around mad perceptions which degrade the subject, it takes aim at the vast majority of the focus of continental philosophy. While Lovecraft's acidic materialism clearly assaults any romantic concept of being from the outside, Ligotti attacks consciousness from the inside: Just a little doubt slipped into the mind, a little trickle of suspicion in the bloodstream, and all those eyes of ours, one by one, open up to the world and see its horror [...] Not even the solar brilliance of a summer day will harbor you from horror. For horror eats the light and digests it into darkness. Clearly, the weird fiction of Lovecraft and Ligotti amount to a anti-anthrocentric onslaught against the ramparts of correlationist continental philosophy. /3/ – Shoggothic Materialism or the Formless Formless protoplasm able to mock and reflect all forms and organs and processes—viscous agglutinations of bubbling cells—rubbery fifteen-foot spheroids infinitely plastic and ductile—slaves of suggestion, builders of cities—more and more sullen, more and more intelligent, more and more amphibious, more and more imitative—Great God! What madness made even those blasphemous Old Ones willing to use and to carve such things? H.P. Lovecraft. “At the Mountains of Madness” On the other hand, affirming that the universe resembles nothing and is only formless amounts to saying that the universe is something like a spider or spit. Georges Bataille. “Formless”. The Shoggoths feature most prominently in H.P. Lovecraft's shortstory “At the Mountains of Madness” where they are described in the following manner: It was a terrible, indescribable thing vaster than any subway train – a shapeless congeries of protoplasmic bubbles, faintly self -luminous, and with myriads of temporary eyes forming and un-forming as pustules of greenish light all over the tunnel-filling front that bore down upon us, crushing the frantic penguins and slithering over the glistening floor that it and its kind had swept so evilly free of all litter. The term is a litmus test for materialism itself as the Shoggoth is an amorphous creature. The Shoggoths were living digging machines bio engineered by the Elder Things, and their protoplasmic bodies being formed into various tools by their hypnotic powers. The Shoggoths eventually became self aware and rose up against their masters in an ultimately failed rebellion. After the Elder Ones retreated into the oceans leaving the Shoggoths to roam the frozen wastes of the Antarctic. The onto-genesis of the Shoggoths and their gross materiality, index the horrifyingly deep time of the earth a concept near and dear to Lovecraft's formulation of horror as well as the fear of intelligences far beyond, and far before, the ascent of humankind on earth and elsewhere. The sickly amorphous nature of the Shoggoths invade materialism at large, where while materiality is unmistakably real ie not discursive, psychological, or otherwise overly subjectivist, it questions the relation of materialism to life. As Eugene Thacker writes: The Shoggoths or Elder Things do not even share the same reality with the human beings who encounter them—and yet this encounter takes place, though in a strange no-place that is neither quite that of the phenomenal world of the human subject or the noumenal world of an external reality. Amorphous yet definitively material beings are a constant in Lovecraft's tales. In his tale “The Dream-Quest of Unknown Kadatth” Lovecraft describes Azathoth as, “that shocking final peril which gibbers unmentionably outside the ordered universe,” that, “last amorphous blight of nethermost confusion which blashphemes and bubbles at the centre of all infinity,” who, “gnaws hungrily in inconceivable, unlighted chambers beyond time”. Azathoth's name may have multiple origins but the most striking is the alchemy term azoth which is both a cohesive agent and a acidic creation pointing back to the generative and the decayed. The indistinction of generation and degradation materially mirrors the blur between the natural and the unnatural as well as life and non-life. Lovecraft speaks of the tension between the natural and the unnatural is his short story “The Unnameable.” He writes, “if the psychic emanations of human creatures be grotesque distortions, what coherent representation could express or portray so gibbous and infamous a nebulousity as the spectre of a malign, chaotic perversion, itself a morbid blasphemy against Nature?”. Lovecraft explores exactly the tension outlined at the beginning of this chapter, between life and thought. At the end of his short tale Lovecraft compounds the problem as the unnameable is described as “a gelatin—a slime—yet it had shapes, a thousand shapes of horror beyond all memory”. Deleuze suggests that becoming-animal is operative throughout Lovecraft's work, where narrators feel themselves reeling at their becoming non-human or of being the anomalous or of becoming atomized. Following Eugene Thacker however, it may be far more accurate to say that Lovecraft's tales exhibit not a becoming-animal but a becoming-creature. Where the monstrous breaks the purportedly fixed laws of nature, the creature is far more ontologically ambiguous. The nameless thing is an altogether different horizon for thought. The creature is either less than animal or more than animal – its becoming is too strange for animal categories and indexes the slow march of thought towards the bizarre. This strangeness is, as aways, some indefinite swirling in the category of immanence and becoming. Bataille begins “The Labyrinth” with the assertion that being, to continue to be, is becoming. More becoming means more being hence the assertion that Bataille's barking dog is more than the sponge. This would mean that the Shoggotth is altogether too much being, too much material in the materialism. Bataille suggests that there is an immanence between the eater and the eaten, across the species and never within them. That is, despite the chaotic storm of immanence there must remain some capacity to distinguish the gradients of becoming without reliance upon, or at least total dependence upon, the powers of intellection to parse the universe into recognizable bits, properly digestible factoids. That is, if we undo Deleuze's aforementioned valorization of sense which, for his variation of materialism, performed the work of the transcendental, but refuse to reinstate Kant's transcendental disjunction between thing and appearance, then it must be a quality of becoming-as-being itself which can account for the discernible nature of things by sense. In an interview with Peter Gratton, Jane Bennett formulates the problem thusly: What is this strange systematicity proper to a world of Becoming? What, for example, initiates this congealing that will undo itself? Is it possible to identify phases within this formativity, plateaus of differentiation? If so, do the phases/plateaus follow a temporal sequence? Or, does the process of formation inside Becoming require us to theorize a non-chronological kind of time? I think that your student’s question: “How can we account for something like iterable structures in an assemblage theory?” is exactly the right question. Philosophy has erred too far on the side of the subject in the subject-object relation and has furthermore, lost the very weirdness of the non-human. Beyond this, the madness of thought need not override. /4/ - Ventriloquial Idealism or the Externality of Thought My aim is the opposite of Lovecraft's. He had an appreciation for natural scenery on earth and wanted to reach beyond the visible in the universe. I have no appreciation for natural scenery and want the objective universe to be a reflection of a character. Thomas Ligotti. “Devotees of Decay and Desolation.” Unless life is a dream, nothing makes sense. For as a reality, it is a rank failure [….] Horror is more real than we are. Thomas Ligotti. “Professor Nobody's Little Lectures on Supernatural Horror”. Thomas Ligotti's tales are rife with mannequins, puppets, and other brainless entities which of replace the valorized subject of philosophy – that of the free thinking human being. His tales such as “The Dream of the Manikin” aim to destroy the rootedness of consciousness. James Trafford has connected the anti-egoism of Ligotti to Thomas Metzinger – where the self is at best an illusion and we plead desperately for someone else to acknowledge that we are real. Trafford has stated it thus, “Life is played out as an inescapable puppet show, an endless dream in which the puppets are generally unaware that they are trapped within a mesmeric dance of whose mechanisms they know nothing and over which they have no control”. An absolute materialism, for Ligotti, implies an alienation of the idea which leads to a ventriloquil idealism. As Ligotti notes in an interview, “the fiasco and nightmare of existence, the particular fiasco and nightmare of human existence, the sense that people are puppets of powers they cannot comprehend, etc.” And then further elaborates that,“[a]ssuming that anything has to exist, my perfect world would be one in which everyone has experienced the annulment of his or her ego. That is, our consciousness of ourselves as unique individuals would entirely disappear”. The externality of the idea leads to the unfortunate consequence of consciousness eating at itself through horror which, for Ligotti, is more real than reality and goes beyond horror-as-affect. Beyond this, taking together with the unreality of life and the ventriloquizing of subjectivity, Ligotti's thought becomes an idealism in which thought itself is alien and ultimately horrifying. The role of human thought and the relation of non-relation of horror to thought is not completely clear in Ligotti's The Conspiracy Against the Human Race. Ligotti argues in his The Conspiracy Against the Human Race,that the advent of thought is a mistake of nature and that horror is being in the sense that horror results from knowing too much. Yet, at the same time, Ligotti seems to suggest that thought separates us from nature whereas, for Lovecraft, thought is far less privileged – mind is just another manifestation of the vital principal, it is just another materialization of energy. In his brilliant “Prospects for Post-Copernican Dogmatism” Iain Grant rallies against the negative definition of dogmatism and the transcendental, and suggests that negatively defining both over-focuses on conditions of access and subjectivism at the expense of the real or nature. With Schelling, who is Grant's champion against the subjectivist bastions of both Fichte and Kant, Ligotti's idealism could be taken as a transcendental realism following from an ontological realism. Yet the transcendental status of Ligotti's thought move towards a treatment of the transcendental which may threaten to leave beyond its realist ground. Ligotti states: Belief in the supernatural is only superstition. That said, a sense of the supernatural, as Conrad evidenced in Heart of Darkness, must be admitted if one's inclination is to go to the limits of horror. It is the sense of what should not be- the sense of being ravaged by the impossible. Phenomenally speaking, the super-natural may be regarded as the metaphysical counterpart of insanity, a transcendental correlative of a mind that has been driven mad. Again, Ligotti equates madness with thought, qualifying both as supernatural while remaining less emphatic about the metaphysical dimensions of horror. The question becomes one of how exactly the hallucinatory realm of the ideal relates to the black churning matter of Lovecraft's chaos of elementary particles. In his tale “I Have a Special Plan for This World” Ligotti formulates thus: A: There is no grand scheme of things. B: If there were a grand scheme of things, the fact – the fact – that we are not equipped to perceive it, either by natural or supernatural means, is a nightmarish obscenity. C: The very notion of a grand scheme of things is a nightmarish obscenity. Here Ligotti is not discounting metaphysics but implying that if it does exist the fact that we are phenomenologically ill-equipped to perceive that it is nightmarish. For Ligotti, nightmare and horror occur within the circuit of consciousness whereas for Lovecraft the relation between reality and mind is less productive on the side of mind. It is easier to ascertain how the Kantian philosophy is a defense against the diseases of the head as Kant armors his critical enterprise from too much of the world and too much of the mind. The weird fiction of both Lovecraft and Ligotti demonstrates that there is too much of both feeding into one another in a way that corrodes the Kantian schema throughly, breaking it down into a dead but still ontologically potentiated nigredo. The haunting, terrifying fact of Ligotti's idealism is that the transcendental motion which brought thought to matter, while throughly material and naturalized, brings with it the horror that thought cannot be undone without ending the material that bears it either locally or completely. Thought comes from an elsewhere and an elsewhen being-in-thought. The unthinkable outside thought is as maddening as the unthought engine of thought itself within thought which doesn't exist except for the mind, the rotting décor of the brain. /5/ - Hyperstitional Transcendental Paranoia or Self -Expelled Thought Weird fiction has been given some direct treatment in philosophy in the mad black Deleuzianism of Nick Land. Nick Land along with others in the 1990s created the Cyber Culture Research Unit as well as the research group Hyperstition. The now defunct hyperstitional website, an outgrowth of the Cyber Culture Research Unit, defined hyperstition in the following fourfold: 1-Element of effective culture that makes itself real. 2-Fictional quantity functional as a time-traveling device. 3-Coincidence intensifier. 4-Call to the Old Ones. The distinctively Lovecraftian character of hyperstition is hard to miss as is its Deleuzo-Guattarian roots. In the opening pages of A Thousand Plateaus Deleuze and Guattari write, “We have been criticized for over-quoting literary authors. But when one writes, the only question is which other machine the literary machine can be plugged into”. The indisinction of literature and philosophy mirrors the mess of being and knowing as post-correlationist philosophy, where philosophy tries to make itself real where literature, especially the weird, aims itself at the brain-circuit of horror. The texts of both Lovecraft and Ligotti work through horror as epistemological plasticity meeting with proximity as well as the deep time of Lovecraft and the glacially slow time of paranoia in Ligotti. Against Deleuze, and following Brassier, we cannot allow the time of consciousness, the Bergsonian time of the duree, to override natural time, but instead acknowledge that it is an unfortunate fact of existence as a thinking being. Horror-time, the time of consciousness, with all its punctuated moments and drawn out terrors, cannot compare to the deep time of non-existence both in the unreachable past and the unknown future. The crystalline cogs of Kant's account of experience as the leading light for the possibility of metaphysics must be throughly obliterated. His gloss of experience in Prolegomena to any Future Metaphysics could not be more sterile: Experience consists of intuitions, which belong to the sensibility, and of judgments, which are entirely a work of the understanding. But the judgments which the understanding makes entirely out of sensuous intuitions are far from being judgments of experience. For in the one case the judgment connects only the perceptions as they are given in sensuous intuition [....] Experience consists in the synthetic connection of appearances in consciousness, so far as this connection is necessary. Here it is difficult to dismiss the queasiness that Kant's legalism induces upon sight for both Badiou and David-Menard. Kant's thought becomes, as Foucault says when reflecting on Sade's text in relation to nature, “the savage abolition of itself”. For Badiou, Kant's philosophy simply closes off too much of the outside, freezing the world of thought in an all too limited formalism. Critical philosophy is simply the systematized quarantine on future thinking, on thinking which would threaten the formalism which artificially grants thought its own coherency in the face of madness. Even the becoming-mad of Deleuze, while escaping the rumbling ground, makes grounds for itself, mad grounds but grounds which are thinkable in their affect. The field of effects allows for Deleuze's aesthetic and radical empiricism, in which effects and/or occasions make up the material of the world to be thought as a chaosmosis of simulacra. Given a critique of an empiricism of aesthetics, of the image, it may be difficult to justify an attack on Kantian formalism with the madness of literature, which does not aim to make itself real but which we may attempt to make real. That is, how do Lovecraft's and Ligotti's materials, as materials for philosophy to work on, differ from either the operative formalisms of Kant or the implicitly formalized images of Deleuzian empiricism? It is simply that such texts do not aim to make themselves real, and make claims to the real which are more alien to us than familiar, which is why their horror is immediately more trustworthy. This is the madness which Blanchot discusses in The Infinite Conversation through Cervantes and his knight – the madness of book-life, of the perverse unity of literature and life a discussion which culminates in the discussion of one of the weird's masters, that of Kafka. The text is the knowing of madness, since madness, in its moment of becoming-more-mad, cannot be frozen in place but by the solidifications of externalizing production. This is why Foucault ends his famous study with works of art. Furthermore extilligence, the ability to export the products of our maligned brains, is the companion of the attempts to export, or discover the possibility of intelligences outside of our heads, in order for philosophy to survive the solar catastrophe. To borrow again from Deleuze, writing is inseparable from becoming. The mistake is to believe that madness is reabsorbed by extilligence, by great works, or that it could be exorcised by the expelling of thought into the inorganic or differently organic. Going out of our heads does not guarantee we will no longer mean we cannot still go out of our minds. This is simply because of the outside, of matter, or force, or energy, or thing-in-itself, or Schopenhauerian Will. In Lovecraft’s “The Music of Erich Zahn” an “impoverished student of metaphysics” becomes intrigued by strange viol music coming from above his room. After meeting the musician the student discovers that each night he plays frantic music at a window in order to keep some horridness at bay, some “impenetrable darkness with chaos and pandemonium”. The aesthetic defenses provided by the well trained brain can bear the hex of matter for so long, the specter of unalterability within it which too many minds obliterate, collapsing everything before the thought of thought as thinkable or at least noetically mutable on our own terms. Transcendental paranoia is the concurrent nightmare and promise of Paul Humphrey's work, of being literally out of our minds. It is the gothic counterpart of thinking non-conceptually but also of thinking never belonging to any instance of purportedly solid being. As Bataille stated, “At the boundary of that which escapes cohesion, he who reflects within cohesion realizes there is no longer any room for him” Thought is immaterial only to the degree that it is inhuman, it is a power that tries, always with failure, to ascertain its own genesis. Philosophy, if it can truly return to the great outdoors, if it can leave behind the dead loop of the human skull, must recognize not only the non-priority of human thought, but that thought never belongs to the brain that thinks it, thought comes from somewhere else. To return to the train image from the beginning “a locomotive rolling on the surface of the earth is the image of continuous metamorphosis” this is the problem of thought, and of thinking thought, of being no longer able to isolate thought, with only a thought-formed structure. [1] One of the central tenets of Francois Laruelle's non-philosophy is that philosophy has traditionally operated on material already presupposed as thinkable instead of trying to think the real in itself. Philosophy, according to Laruelle, remains fixated on transcendental synthesis which shatters immanence into an empirical datum and an a prori factum which are then fused by a third thing such as the ego. For a critical account of Laruelle's non-philosophy see Ray Brassier's Nihil Unbound. (shrink)

What kind of technology is the piano? It was once a distinctly everyday technology. In the bourgeois home of the nineteenth century it became an emblematic figure of gendered social life, its role shifting between visually pleasing piece of furniture, source of light entertainment, and expression of cultured upbringing. It performed this role unobtrusively, acting as a transparent mediator of social relations. To the composer of concert music it was, and sometimes still is, says Samuel Wilson, like the philosopher’s table: (...) “an assumed background on which one writes.” Like other instruments standard to Western art music, the piano was designed to facilitate the production of a consistent and refined timbre. More than most other such instruments, the piano also facilitated a kind of sonic neutrality. With its wide pitch range and smoothing of the percussive attack of its predecessor instruments, the piano presented composers with a technological means of approaching composition from a seemingly objective vantage point. It exemplified, in Heideggerian terms, the instrumentality of the instrument, serving as a mediator between idea and expression that apparently adds no character of its own. -/- This notion of the invisibility, or transparency, of the mediations that musical technologies such as the piano enact is one of my areas of concern here. So too is its inverse: when these mediations become visible or opaque. Transparency has been a topic of significant recent theoretical attention. Stefanos Geroulanos, for example, has detailed how the supposed transparency of intersubjective, epistemological, and social relations was a major point of critique in postwar French thought, where the supposition of transparency was taken to suppress how the world was “complex, layered, structured, filled with heterogeneity” – and, as I will stress here, contingency. The thinkers Geroulanos considers, from Jean-Paul Sartre through to Jean-François Lyotard, can be said to be united in their refusal to invisibilise mediatedness. From a starting point of conceiving of the piano as a technological artifact, and in particular from John Cage’s ‘prepared piano,’ I will explore how a similar concern has appeared in musical contexts, albeit not without the risk of reversion back into a logic of transparency. (shrink)

Recent authors, emphasizing Newman’s distaste for natural theology—especially William Paley’s design argument—have urged us to follow Newman’s lead and reject design arguments. But I argue that Newman’s own argument for God’s existence (his argument from conscience) fails without a supplementary design argument or similar reason to think our faculties are truth-oriented. In other words, Newman appears to need the kind of argument he explicitly rejects. Finding Newman’s rejection of natural theology to stem primarily from factors other than worries about cogency, (...) however, I further argue that there is little reason not to pursue design arguments in order to save the argument from conscience. (shrink)

Many philosophical thought experiments and arguments involve unusual cases. We present empirical reasons to doubt the reliability of intuitive judgments and conclusions about such cases. Inferences and intuitions prompted by verbal case descriptions are influenced by routine comprehension processes which invoke stereotypes. We build on psycholinguistic findings to determine conditions under which the stereotype associated with the most salient sense of a word predictably supports inappropriate inferences from descriptions of unusual (stereotype-divergent) cases. We conduct an experiment that combines plausibility ratings (...) with pupillometry to document this “salience bias.” We find that under certain conditions, competent speakers automatically make stereotypical inferences they know to be inappropriate. (shrink)

Children from various countries have been acknowledged and studied for their ability to philosophize, while, unfortunately, Filipino children have not received similar recognition. In this paper, I make a rather unpopular claim that Filipino children can and already are doing philosophy in their efforts to make sense of their existential conditions. “Doing philosophy” here refers to the act of being perplexed by one's own or other people's experiences and making an effort to comprehend them. Filipino children, are a vast and (...) diverse group, coming from various backgrounds, speaking different or even multiple languages, and representing rich cultures and unique circumstances. This diversity adds richness to the wide array of experiences from which existential questions can emerge. However, to truly comprehend the philosophical thinking of Filipino children, they need opportunities and guidance to explore their existential questions and solutions, regardless of how tentative or rudimentary these may seem to adults. Without such opportunities, it remains unclear to what extent their thinking engages with philosophical themes and issues. This not only offers Filipino adults a view of children’s inner worlds but also brings fresh perspectives to commonly held assumptions. (shrink)

The role of certitude in our mental lives is, to put it mildly, controversial. Many current epistemologists (including epistemologists of religion) eschew certitude altogether. Given his emphasis on certitude, some have maintained that John Henry Newman was an infallibilist about knowledge. In this paper, we argue that a careful examination of his thought (especially as seen in the Grammar of Assent) reveals that he was an epistemic fallibilist. We first clarify what we mean by fallibilism and infallibilism. Second, we explain (...) why some have read Newman as an infallibilist. Third, we offer two arguments that Newman is at least a fallibilist in a weak sense. In particular, the paradox he seeks to resolve in the Grammar and his dispute with John Locke both indicate that he is at least a weak fallibilist. We close with a consideration of whether Newman is a fallibilist in a much stronger sense as well. (shrink)

It is now widely accepted that a scientifically credible conception of human nature must reject the folkbiological idea of a fixed, inner essence that makes us human. We argue here that to understand human nature is to understand the plastic process of human development and the diversity it produces. Drawing on the framework of developmental systems theory and the idea of developmental niche construction we argue that human nature is not embodied in only one input to development, such as the (...) genome, and that it should not be confined to universal or typical human characteristics. Both similarities and certain classes of differences are explained by a human developmental system that reaches well out into the 'environment'. We point to a significant overlap between our account and the ‘Life History Trait Cluster’ account of Grant Ramsey, and defend the developmental systems account against the accusation that trying to encompass developmental plasticity and human diversity leads to an unmanageably complex account of human nature. (shrink)

The article traces the evolution and crystallization of Buber’s philosophy of dialogue. It focuses on his consideration of the epistemological and ontological issues attendant to the principium individuationis, the subject of his doctoral dissertation of 1904. Culminating with the publication of Ich und Du in 1923, this process was punctuated by life experiences that led him to affirm rather than to seek to transcend the principium individuationis as the ontological ground of being manifest in the matrix of everyday life, which (...) we are beckoned to sanctify through I-Thou relations. (shrink)

Huang-Lao is now generally regarded as a set of ideas that gained currency from the final stages of the Warring States period to well into the Han dynasty. "Huang" stands for Huangdi, the Yellow Emperor; "Lao" refers to Laozi, the "Old Master," who is traditionally regarded as the founder of Daoism. Huang-Lao is thus a combination of ideas attributed to the mythical figures of the Yellow Emperor and Laozi. What those ideas are and how they have manifested themselves in Chinese (...) history remains the subject of heated debate. (shrink)

There is little more common in ethics than to think pain is intrinsically bad and pleasure is intrinsically good. A Humean-style error theory of the axiology of pain and pleasure is developed against these commonsense claims. We defend the thesis that the value of pain and pleasure is always contingent and only instrumental. We survey prominent theories of both intrinsic value and pain/pleasure, all of which assume that pain and pleasure are intrinsically valuable. We base our error theory on counterexamples (...) to this assumption, upon which these theories falter, and a theory of pain and pleasure which derives their value solely from their evolutionary function. (shrink)

In this essay, we consider the formal and ontological implications of one specific and intensely contested dialectical context from which Deleuze’s thinking about structural ideal genesis visibly arises. This is the formal/ontological dualism between the principles, ἀρχαί, of the One (ἕν) and the Indefinite/Unlimited Dyad (ἀόριστος δυάς), which is arguably the culminating achievement of the later Plato’s development of a mathematical dialectic.3 Following commentators including Lautman, Oskar Becker, and Kenneth M. Sayre, we argue that the duality of the One and (...) the Indefinite Dyad provides, in the later Plato, a unitary theoretical formalism accounting, by means of an iterated mixing without synthesis, for the structural origin and genesis of both supersensible Ideas and the sensible particulars which participate in them. As these commentators also argue, this duality furthermore provides a maximally general answer to the problem of temporal becoming that runs through Plato’s corpus: that of the relationship of the flux of sensory experiences to the fixity and order of what is thinkable in itself. Additionally, it provides a basis for understanding some of the famously puzzling claims about forms, numbers, and the principled genesis of both attributed to Plato by Aristotle in the Metaphysics, and plausibly underlies the late Plato’s deep considerations of the structural paradoxes of temporal change and becoming in the Parmenides, the Sophist, and the Philebus. After extracting this structure of duality and developing some of its formal, ontological, and metalogical features, we consider some of its specific implications for a thinking of time and ideality that follows Deleuze in a formally unitary genetic understanding of structural difference. These implications of Plato’s duality include not only those of the constitution of specific theoretical domains and problematics, but also implicate the reflexive problematic of the ideal determinants of the form of a unitary theory as such. We argue that the consequences of the underlying duality on the level of content are ultimately such as to raise, on the level of form, the broader reflexive problem of the basis for its own formal or meta-theoretical employment. We conclude by arguing for the decisive and substantive presence of a proper “Platonism” of the Idea in Deleuze, and weighing the potential for a substantive recuperation of Plato’s duality in the context of a dialectical affirmation of what Deleuze recognizes as the “only” ontological proposition that has ever been uttered. This is the proposition of the univocity of Being, whereby “being is said in the same sense, everywhere and always,” but is said (both problematically and decisively) of difference itself. (shrink)

Kant distinguishes between autonomous and heteronomous agents. Because Kant is concerned with the nature of moral action, not its consequences, he isn’t concerned with whether autonomous agents achieve better outcomes than heteronomous agents. And yet, the question about the expected outcomes of the different types of agency is an interesting one to pursue, for it is not obvious up front which type of agent would achieve better outcomes. This paper uses game theory to explore and begin to answer this question. (...) We present a game theoretic examination of five forms of heteronomy and their corresponding forms of autonomy. We show that across a significant range of interactive situations agents who have the autonomy to choose between selfishness and either empathy or altruism achieve expected material payoffs equal to the maximum expected material payoffs of the corresponding heteronomous agents. We also show that across the same range of interactions agents who have the autonomy to choose between a deontological moral law and selfishness, empathy, or altruism achieve higher expected material payoffs than the corresponding heteronomous agents. (shrink)

This essay offers a reconstruction of Aristotle’s account of the voluntary in the Nicomachean Ethics, arguing that the voluntary grounds one notion of responsibility with two levels, and therefore both rational and non-rational animals are responsible for voluntary actions. Aristotle makes no distinction between causal and moral responsibility in the NE; rather, voluntariness and prohairesis form different bases for responsibility and make possible different levels of responsibility, but both levels of responsibility fall within the ethical sphere and are aptly appraised. (...) Important differences between the two levels remain. Animals and children are aptly appraised for direct voluntary actions. Conversely, only adults capable of prohairesis or rational choice are appraised for indirect voluntary actions—psychologically compelled actions that stem from character. Furthermore, while children and animals are responsible for actions, only adults casually contribute to the formation of their characters and thus are aptly appraised for character traits. (shrink)

Knowledge-first theories of justification are theories of justification that give knowledge priority when it comes to explaining when and why someone has justification for an attitude or an action. The emphasis of this article is on knowledge-first theories of justification for belief. As it turns out, there are a number of ways of giving knowledge priority when theorizing about justification, and what follows is a survey of more than a dozen existing options that have emerged in the early 21st century (...) since the publication of Timothy Williamson’s *Knowledge and Its Limits*. This article traces several of the general theoretical motivations that have been offered for putting knowledge first in the theory of justification. This is followed by an examination of existing knowledge-first theories of justification and their standing objections. These objections are largely, but not exclusively, concerned with the extensional adequacy of knowledge-first theories of justification. There are doubtless more ways to give knowledge priority in the theory of justified belief than are covered here, but the survey is instructive because it highlights potential shortcomings that would-be knowledge-first theorists of justification may wish either to avoid or else to be prepared with a suitable error theory. This entry concludes with a reflection about the extent to which the short history of, arguably, failed attempts to secure an unproblematic knowledge-first account of justified belief has begun to resemble the older Gettier dialectic. (shrink)

In this chapter, Gage and McAllister respond to various objections to the phenomenal conservative position in religious epistemology. In particular, they respond to the objections that seemings are the ultimate source of justification, that PC makes epistemic justification too easy, that PC involves conceptual circularity, and that PC lacks an objective connection to truth.

Excerpt: In this essay I explore the nature of the necessity of historical development in Nietzsche’s genealogy of Judeo-Christian moral values. I argue that the progression of moral stages in Nietzsche’s study is ordered in such a way that the failure of each stage is logically and structurally necessary, that each failure structures the resultant system or paradigm, but that the historical manifestation of moral paradigms coinciding with predicted or projected theoretical structures is contingent upon a multitude of other historical (...) factors. Therefore, the systematic internal failures of moral stages allow for, but do not cause, successive events. (shrink)

This essay is titled "Critique the Postulation of the Historical Law Theory and relate it to African Law. The postulation of the historical law school that law emanates from customs through an ordered pattern of systematized progress into a codified system in relation to African law forms the crust of this essay. To achieve this task, this essay adopts a critical method in exposing c postulation of the historical law school and the African Law (keeping in mind the Ukelle communal (...) Law System). This essay questions whether there can be an independent law made or promulgated without targeting a given people or that there can be a people-free law? This essay claims that like the historical law school, laws emanate from their ground norms but insists that unlike the historical law school, laws in Ukelle Traditional System do not necessarily have to submit to through the rigor of systematic and strict evolutionary pattern of progress. Like Herder, this essay avers that there is a unique character with each culture, and as such Ukelle Traditional Law does not have to submit to any universal character of law. (shrink)

This article begins with some common or well-known sentiments about the present pandemic era and our experience of it, and moves by way of these toward discussion of the concepts of human existence and the “world” in the broadest sense of both terms. Departing from but also radicalizing the notion that “everything changed” in this pandemic time, I discuss certain logical difficulties that pertain to conceiving of or coherently talking about strict totalities which would include our own selves. This will (...) have significant consequences for our conception of the world (when taken in its absolute or broadest sense), and in what sense there are or could be multiple such immersive wholes of experience. Ultimately, I will suggest that in being able to name such pervasive or all encompassing phenomena, phenomena which are “always more” than what it is possible for us to indicate, that human existence is fundamentally liminal, or essentially between and borderline. Being essential or fundamental, this liminality or betweenness will form the basis which precedes and makes possible the apparently simple activities of, for instance, counting time or comparing and contrasting ordinary things, activities which would otherwise seem to require no outside support or conditions. (shrink)

The present article illustrates a conflict between the claim that rational belief sets are closed under deductive consequences, and a very inclusive claim about the factors that are sufficient to determine whether it is rational to believe respective propositions. Inasmuch as it is implausible to hold that the factors listed here are insufficient to determine whether it is rational to believe respective propositions, we have good reason to deny that rational belief sets are closed under deductive consequences.

In previous work, we studied four well known systems of qualitative probabilistic inference, and presented data from computer simulations in an attempt to illustrate the performance of the systems. These simulations evaluated the four systems in terms of their tendency to license inference to accurate and informative conclusions, given incomplete information about a randomly selected probability distribution. In our earlier work, the procedure used in generating the unknown probability distribution (representing the true stochastic state of the world) tended to yield (...) probability distributions with moderately high entropy levels. In the present article, we present data charting the performance of the four systems when reasoning in environments of various entropy levels. The results illustrate variations in the performance of the respective reasoning systems that derive from the entropy of the environment, and allow for a more inclusive assessment of the reliability and robustness of the four systems. (shrink)

For Rawls, the demands of justice compete with moral and religious obligations that are part of citizens’ comprehensive doctrines. The ways we love are shaped by our comprehensive doctrines; however, love can also stand in opposition to our moral and religious beliefs. I will argue that love – spousal, familial and associational – constitutes its own register of values along with its own set of obligations. For this reason love confronts not only our moral and religious beliefs, it also confronts (...) the demands and requirements of justice. Rawls has worked out a negotiated peace between the obligations of justice and the demands of citizens’ comprehensive doctrines in the form of an overlapping consensus on a free-standing political conception of justice. I will argue that in Rawls’s philosophy, justice has not yet made peace with love. (shrink)

Sometimes it’s reasonable to reduce confidence in a proposition in response to gaining etiological information. Suppose, for example, a theist learns that her theism is ‘due to’ her religious upbringing. There is a clear range of cases where it would be reasonable for her to respond by slightly decreasing her confidence in God’s existence. So long as reasonability and justification are distinct, this reasonability claim would appear consistent with the thesis that this kind of etiological information cannot, all by itself, (...) affect one’s justification. In what follows, I argue that this is mistaken. For, even if reasonability and justification are distinct, the reasonability of decreasing confidence in response to etiological information must be explained in terms of a decrease in justification. The argument to follow threatens not only the stronger thesis that etiological information never defeats justification but the substantially weaker thesis, advocated by various authors, that justification is defeated by etiological information in only a limited range of circumstances. I go on to show how the arguments en route to this conclusion have much wider epistemological ramifications. (shrink)

A review of Thomas Nagel's book Mind and Cosmos.

The Nash counterfactual considers the question: what would happen were I to change my behaviour assuming no one else does. By contrast, the Kantian counterfactual considers the question: what would happen were everyone to deviate from some behaviour. We present a model that endogenizes the decision to engage in this type of Kantian reasoning. Autonomous agents using this moral framework receive psychic payoffs equivalent to the cooperate-cooperate payoff in Prisoner’s Dilemma regardless of the other player’s action. Moreover, if both interacting (...) agents play Prisoner’s Dilemma using this moral framework, their material outcomes are a Pareto improvement over the Nash equilibrium. (shrink)

Don Ihde has characterized his philosophy as "phenomenology + pragmatism." This article argues that Ihde's pragmatism can be understood as consistency with two philosophical commitments from the first generation of American pragmatists (e.g. Peirce, James, Dewey and Addams). First, Ihde's notion of embodiment relations for tools and techniques is consistent with the organism-environment relational epistemology of these thinkers. Second, his desire to dissociate himself from romantic and neo-idealist readings of the phenomenological tradition link him with their naturalism.

The chapter discusses two points of intersection between the communication of science-based information about risk and philosophical ethics. The first is a logically unnecessary bias toward consequentialist ethics, and a corresponding tendency to overlook the significance of deontological and virtue based ways to interpret the findings of a scientific risk analysis. The second is a grammatical bias that puts scientific communicators at odds with the expectations of a non-scientific audience.

A short summary of the key arguments and theses of Awareness and the Substructure of Knowledge (OUP). Presented at the 2023 meeting of the Pacific APA. Comments given by Ram Neta, Clayton Littlejohn, and Sara Aronowitz.