The nature and structure of time and time-intervals in physical, chemical and biological systems will be elucidated. The relation and dependence among time, energy and taking place of natural processes will be critically analyzed. The bio-processes taking place in nano-time intervals will be identified. Their relevance to nano-bio-science and nano-bio-technology will be developed and nano-time interval-aspect of nano-sciences and nano-technology will be advanced. -/- .

Space-time intervals are the fundamental components of conscious experience, gravity, and a Theory of Everything. Space-time intervals are relationships that arise naturally between events. They have a general covariance (independence of coordinate systems, scale invariance), a physical constancy, that encompasses all frames of reference. There are three basic types of space-time intervals (light-like, time-like, space-like) which interact to create space-time and its properties. Human conscious experience is a four-dimensional space-time continuum created (...) through the processing of space-time intervals by the brain; space-time intervals are the source of conscious experience (observed physical reality). Human conscious experience is modeled by Einstein’s special theory of relativity, a theory designed specifically from the general covariance of space-time intervals (for inertial frames of reference). General relativity is our most accurate description of gravity. In general relativity, the general covariance of space-time intervals is extended to all frames of reference (inertial and non-inertial), including gravitational reference frames; space-time intervals are the source of gravity in general relativity. The general covariance of space-time intervals is further extended to quantum mechanics; space-time intervals are the source of quantum gravity. The general covariance of space-time intervals seamlessly merges general relativity with quantum field theory (the two grand theories of the universe). Space-time intervals consequently are the basis of a Theory of Everything (a single all-encompassing coherent theoretical framework of physics that fully explains and links together all physical aspects of the universe). This theoretical framework encompasses our observed physical reality (conscious experience) as well; space-time intervals link observed physical reality to actual physical reality. This provides an accurate and reliable match between observed physical reality and the physical universe by which we can carry on our activity. The Minkowski metric, which defines generally covariant space-time intervals, may be considered an axiom (premise, postulate) for the Theory of Everything. (shrink)

This short commentary discusses the importance of space-time intervals in scientific study. Space-time intervals underlie special relativity, general relativity, and quantum field theory. In doing so, space-time intervals underlie human conscious experience, gravity, and a theory of everything. Space-time intervals also explain many puzzling scientific phenomena: quantum phenomena, dark matter, dark energy, the origin and evolution of the universe, and the life force. The importance of space-time intervals cannot be overestimated. (...) Two articles published in Neuroquantology explain how all this was established from empirical evidence and theory. (shrink)

Carter (Noûs 55(1):171–198, 2021) argued that while most simple positive numerical sentences are literally false, they can communicate true contents because relevance has a weakening effect on their literal contents. This paper presents a challenge for his account by considering entailments between the imprecise contents of numerical sentences and the imprecise contents of comparatives. I argue that while Carter's weakening mechanism can generate the imprecise contents of plain comparatives such as `A is taller than B', it cannot generate the imprecise (...) contents of comparatives that quantify the difference between their arguments, such as `A is exactly n times as tall as B'. I then propose an alternative theory on which intervals serve as both thick degrees on a scale and denotations of numerical expressions. I argue that the alternative theory can account for the imprecise contents of both forms of comparatives as well as the data that motivate Carter's theory. (shrink)

In this book authors for the first time introduce the notion of super interval matrices using special intervals. The advantage of using super interval matrices is that one can build only one vector space using m × n interval matrices, but in case of super interval matrices we can have several such spaces depending on the partition on the interval matrix.

The processing of time intervals in the sub- to supra-second range by the brain is critical for the interaction of primates with their surroundings in activities, such as foraging and hunting. For an accurate processing of time intervals by the brain, representation of physical time within neuronal circuits is necessary. I propose that time dimension of the physical surrounding is represented in the brain by different types of neuronal oscillators, generating spikes or spike bursts (...) at regular intervals. The proposed oscillators include the pacemaker neurons, tonic inputs, and synchronized excitation and inhibition of inter-connected neurons. Oscillators, which are built inside various circuits of brain, help to form modular clocks, processing time intervals or other temporal characteristics specific to functions of a circuit. Relative or absolute duration is represented within neuronal oscillators by “neural temporal unit,” defined as the interval between regularly occurring spikes or spike bursts. Oscillator output is processed to produce changes in activities of neurons, named frequency modulator neuron, wired within a separate module, represented by the rate of change in frequency, and frequency of activities, proposed to encode time intervals. Inbuilt oscillators are calibrated by (a) feedback processes, (b) input of time intervals resulting from rhythmic external sensory stimulation, and (c) synchronous effects of feedback processes and evoked sensory activity. A single active clock is proposed per circuit, which is calibrated by one or more mechanisms. Multiple calibration mechanisms, inbuilt oscillators, and the presence of modular connections prevent a complete loss of interval timing functions of the brain. (shrink)

In this paper we focus our attention on tableau methods for propositional interval temporal logics. These logics provide a natural framework for representing and reasoning about temporal properties in several areas of computer science. However, while various tableau methods have been developed for linear and branching time point-based temporal logics, not much work has been done on tableau methods for interval-based ones. We develop a general tableau method for Venema's \cdt\ logic interpreted over partial orders (\nsbcdt\ for short). It (...) combines features of the classical tableau method for first-order logic with those of explicit tableau methods for modal logics with constraint label management, and it can be easily tailored to most propositional interval temporal logics proposed in the literature. We prove its soundness and completeness, and we show how it has been implemented. (shrink)

Various understandings and definitions of time will be reviewed. The nature and structure of time will be reviewed and the concepts of time and passage of time will be refreshed. The fundamental role played by energy and four natural forces in the actions, reactions and interactions concerning matter, anti-matter, energy in space and time will be critically analyzed. The reality how time is constructed during the construction of materials will be presented and discussed. The (...) classical and quantum ideas in this regard will be comprehensively studied. How these ideas will give us a fresh insight about the nature, structure and role of time in the construction of materials through natural scientific and manmade processes will be highlighted. The relations among matter, anti-matter, energy and time will be freshly stated. The milli-, micro-, nano, pico-, femto-, atto-times will be qualitatively analyzed considering physical, inorganic, organic and bio-materials and their construction and structure. The physics of timelessness also will be put forward. -/- . (shrink)

For Vajrayana Buddhism, the now is an interval, a boundary, a point of tension and suspension with an atmosphere of uncertainty. It is a bifurcation point of variable length; its name is “bardo.” The bardo is immersed in the conventional, or “seeming” reality. It emerges from what is called the “unstained” ultimate or primordial emptiness or “basal clear light.” Further, the ultimate is not the sphere of cognition. Cognition, including cognition of time, belongs to conventional reality. Buddhahood, in contrast, (...) is a condition of uncompounded knowledge where basic mind blossoms without temporal or other cognitive distinctions, unmade, unfabricated, luminous and pristine. Cyclical existence involves both the ultimate and the conventional as it moves through six bardos—all of which are the effulgent of the basal clear light—until Buddhahood. The six are: the bardo of this life ; the bardo of dream; the bardo of meditation; the bardo of dying; the bardo of dharmata ; and the bardo of existence. Each realm is both ultimate and conventional, and has specific initiation-based yogas to investigate these differences. The process of transition from one to the next involves at least three bodies, one mind, and aspects of speech. In each bardo, the character of the now as embodiment and temporal knowing varies yet a complete and consistent cross-bardo yogic wisdom leads to its total cessation in the basal clear light; the now is extinguished. The author presents, from the viewpoint of a knowledgeable practitioner of over 30 years, an essay on Vajrayana Buddhist time, drawing implications for Fraser’s time typology. The essay will draw from English translations of significant older, tantric texts on dream yoga, deity yoga, the Chod, tantric time, the bardo of death, and empowerment. Useful practices that can be applied by the audience to test the tradition and author’s assertions will be suggested. (shrink)

Within ordinary ---unitary--- quantum mechanics there exist global protocols that allow to verify that no definite event ---an outcome to which a probability can be associated--- occurs. Instead, states that start in a coherent superposition over possible outcomes always remain as a superposition. We show that, when taking into account fundamental errors in measuring length and time intervals, that have been put forward as a consequence of a conjunction of quantum mechanical and general relativity arguments, there are instances (...) in which such global protocols no longer allow to distinguish whether the state is in a superposition or not. All predictions become identical as if one of the outcomes occurs, with probability determined by the state. We use this as a criteria to define events, as put forward in the Montevideo Interpretation of Quantum Mechanics. We analyze in detail the occurrence of events in the paradigmatic case of a particle in a superposition of two different locations. We argue that our approach provides a consistent single-world picture of the universe, thus allowing an economical way out of the limitations imposed by a recent theorem by Frauchiger and Renner showing that having a self-consistent single-world description of the universe is incompatible with quantum theory. In fact, the main observation of this paper may be stated as follows: If quantum mechanics is extended to include gravitational effects to a QG theory, then QG, S, and C are satisfied. (shrink)

I explain in what sense the structure of space and time is probably vague or indefinite, a notion I define. This leads to the mathematical representation of location in space and time by a vague interval. From this, a principle of complementary inaccuracy between spatial location and velocity is derived, and its relation to the Uncertainty Principle discussed. In addition, even if the laws of nature are deterministic, the behaviour of systems will be random to some degree. These (...) and other considerations draw classical physics closer to Quantum Mechanics. An arrow of entropy is also derived, given an arrow of time. Lastly, chaos is given an additional, objective meaning. (shrink)

The physical basis of conscious experience is revealed by direct observation and analysis of any conscious experience. Human conscious experience has an invariant structural mode of organization based on the three types of space-time intervals (light-like, time-like, space-like). Sensory input activates the autonomic nervous system, endocrine system, and ascending reticular activating system to produce the awake conscious state. The dorsal and ventral frontoparietal attention networks are activated. Dorsal and ventral cortical functional streams carry “what”, “where”, and “when” (...) information to the medial temporal lobe for the encoding, storage, and recall of conscious experience (episodic memory). Hippocampal place cells and time cells encode events in space and time within spatiotemporal contexts conveyed by entorhinal cortex grid cells and ramping cells. Theta phase precession unifies the encoding of space and time in the hippocampus so that segments of space and time are encoded in the hippocampus. Theta travelling waves ensure that the instantaneous output of the hippocampus consists of topographically-organized segments of space and time, space-time intervals. By parsing spatiotemporal contexts into quantal units of where and when events occur (spacetime intervals), hippocampal neurons bridge, and thereby organize events, in a conceptual organization of events (conscious experience). Space-time intervals are extracted from the hippocampus by a prefrontal cortex-basal ganglia-thalamic-prefrontal cortex loop for the cognitive, affective, and motivational aspects of conscious experience. (shrink)

La psychologie a toujours traité le comportement et l’expérience comme étant enchâssés dans un flux temporel unidimensionnel, « le courant du comportement » dans lequel les événements et les actions occupent des intervalles de temps qui ne se chevauchent pas. Pourtant, une analyse phénoménologique révèle que la structure de nos vies est bien plus riche et intéressante. En utilisant la notion de « quasidécomposabilité » de Herbert Simon, je décris cette structure comme un assemblage d’épisodes quasi-indépendants se réalisant de façon (...) concurrente, et de nature asynchrone. Il s’agit d’une « structure profonde» des vies contrairement à la conception courante qui conçoit les vies comme « plates » Psychology has always treated behavior and experience as embedded in a unidimensional flow in time, the "stream of behavior." This means that events and actions occupy non-overlapping time-intervals in this stream. Nevertheless a phenomenological analysis reveals that the structure of lives is richer and far more interesting. Using Herb Simon's notion of near-decomposability, I describe the structure of lives as a composite of nearly independent strands that run concurrently, and are asynchronous. This is a "deep structure"' of lives in contrast to the current conception, which conceives of lives as "flat." . (shrink)

In bioethics, the first decade of the twenty-first century was characterized by the emergence of interest in the ethical, legal, and social aspects of neuroscience research. At the same time an ongoing extension of the topics and phenomena addressed by neuroscientists was observed alongside its rise as one of the leading disciplines in the biomedical science. One of these phenomena addressed by neuroscientists and moral psychologists was the neural processes involved in moral decision-making. Today both strands of research are (...) often addressed under the label of neuroethics. To understand this development we recalled literature from 1995 to 2012 stored in the Mainz Neuroethics Database (i) to investigate the quantitative development of scientific publications in neuroethics; (ii) to explore changes in the topics of neuroethics research within the defined time interval; (iii) to illustrate the interdependence of different research topics within the neuroethics literature; (iv) to show the development of the distribution of neuroethics research on peer-reviewed journals; and (v) to display the academic background and affiliations of neuroethics Researchers ... (shrink)

A “conceptual spaces” approach is used to formalize Aristotle’s main intuitions about time and change, and other ideas about temporal points of view. That approach has been used in earlier studies about points of view. Properties of entities are represented by locations in multidimensional conceptual spaces; and concepts of entities are identified with subsets or regions of conceptual spaces. The dimensions of the spaces, called “determinables”, are qualities in a very general sense. A temporal element is introduced by adding (...) a time variable to state functions that map entities into conceptual spaces. That way, states may have some permanency or stability around time instances. Following Aristotle’s intuitions, changes and events will not be necessarily instant phenomena, instead they could be processual and interval dependent. Change is defined relatively to the interval during which the change is taking place. Time intervals themselves are taken to represent points of view. To have a point of view is to look at the world as it is in the selected interval. Many important concepts are relativized to intervals, for instance change, events, identity, ontology, potentiality, etc. The definition of points of view as intervals allows to compare points of view in relation to all these concepts. The conceptual space approach has an immediate semantic and structural character, but it is tempting to develop also logics to describe them. A formal language is introduced to show how this could be done. (shrink)

It has been commonly claimed that prehistoric warfare in Japan began in the Yayoi period. Population increases due to the introduction of agriculture from the Korean Peninsula to Japan resulted in the lack of land for cultivation and resources for the population, eventually triggering competition over land. This hypothesis has been supported by the demographic data inferred from historical changes in Kamekan, a burial system used especially in the Kyushu area in the Yayoi period. The present study aims to examine (...) the previous claim by using an expanded dataset of human skeletal remains and Kamekan. First, in order to quantify the intensity of warfare, we developed a database of injured individuals found in the middle phase of the Yayoi period in two large populations in the northern Kyushu area, the Fukuoka plain and the upperand middle-stream of the Homan River. Second, we collected Kamekan data from site reports published after 1990 and constructed a comprehensive database to infer the demography in these areas. Finally, we compared the frequency of injured individuals and the inferred demography. The results suggest that the frequency of injured individuals and the population increase tended to be higher at the upper- and middle-stream of the Homan River than on the Fukuoka plain. Different assumptions of the lifetime of each type of Kamekan can produce mixed results on the relationship between demography and the frequency of injured individuals. They were positively correlated under the traditional assumption of constant time intervals, while there was no correlation using time intervals based on carbon dating by the National Museum of Japanese History. Thus, our results are partially consistent with the previous claim that the population increase and the lack of land and resources due to the introduction of agriculture were causes of warfare in the northern Kyushu area in the middle phase of the Yayoi period. (shrink)

Ontologies of living things are increasingly grounded on the concepts and practices of current life science. Biological development is a process, undergone by living things, which begins with a single cell and (in an important class of cases) ends with formation of a multicellular organism. The process of development is thus prima facie central for ideas about biological individuality and organismality. However, recent accounts of these concepts do not engage developmental biology. This paper aims to fill the gap, proposing the (...) lineage view of stem cells as an ontological framework for conceptualizing organismal development. This account is grounded on experimental practices of stem cell research, with emphasis on new techniques for generating biological organization in vitro. On the lineage view, a stem cell is the starting point of a cell lineage with a specific organismal source, time-interval of existence, and ‘tree topology’ of branch-points linking the stem to developmental termini. The concept of ‘enkapsis’ accommodates the cell-organism relation within the lineage view; this hierarchical notion is further explicated by considering the methods and results of stem cell experiments. Results of this examination include a (partial) characterization of stem cells’ developmental versatility, and the context-dependence of developmental processes involving stem cells. (shrink)

Modern philosophy of mathematics has been dominated by Platonism and nominalism, to the neglect of the Aristotelian realist option. Aristotelianism holds that mathematics studies certain real properties of the world – mathematics is neither about a disembodied world of “abstract objects”, as Platonism holds, nor it is merely a language of science, as nominalism holds. Aristotle’s theory that mathematics is the “science of quantity” is a good account of at least elementary mathematics: the ratio of two heights, for example, is (...) a perceivable and measurable real relation between properties of physical things, a relation that can be shared by the ratio of two weights or two time intervals. Ratios are an example of continuous quantity; discrete quantities, such as whole numbers, are also realised as relations between a heap and a unit-making universal. For example, the relation between foliage and being-a-leaf is the number of leaves on a tree,a relation that may equal the relation between a heap of shoes and being-a-shoe. Modern higher mathematics, however, deals with some real properties that are not naturally seen as quantity, so that the “science of quantity” theory of mathematics needs supplementation. Symmetry, topology and similar structural properties are studied by mathematics, but are about pattern, structure or arrangement rather than quantity. (shrink)

Constitutions enshrine the fundamental values of a people and they build a framework for a state’s public policy. With regard to generational change, their endurance gives rise to two interlinked concerns: the sovereignty concern and the forgone welfare concern. If constitutions are intergenerational contracts, how (in)flexible should they be? This article discusses perpetual constitutions, sunset constitutions, constitutional reform commissions and constitutional conventions, both historically and analytically. It arrives at the conclusion that very rigid constitutions are incompatible with the principle of (...) intergenerational justice. Recurring constitutional reform commissions in fixed time intervals would give each generation of citizens a say without leaning too much to the side of flexibility. (shrink)

In this paper we provide an analysis of dynamic dispositionalism. It is usually claimed that dispositions are dynamic properties. However, there is no exhaustive analysis of dynamism in the dispositional literature. We will argue that the dynamic character of dispositions can be analyzed in terms of three features: (i) temporal extension, (ii) necessary change and (iii) future orientedness. Roughly, we will defend the idea that dynamism entails a continuous view of time, to be analyzed in mathematical terms, where (...) class='Hi'>intervals are its constitutive elements, whose duration lasts as much as a certain change takes to occur (in support of i). Such changes are the necessary components for the flowing of time because we think there cannot be time without change, (thus supporting ii) and that the forward-looking feature of properties is what determines the direction of time (as per iii). The paper is structured in 5 sections. In the first section, we set the problem: we outline and criticize some dispositional theories that defend an unsatisfying notion of dynamism. In the second, third and fourth sections we defend each desideratum for a disposition to be dynamic. Finally, we draw some conclusions and consider potential future research. (shrink)

One vexing question for Desire Satisfactionism is this: At what time do you benefit from a satisfied desire? Recently Eden Lin has proposed an intriguing answer. On this proposal – Asymmetrism – when past-directed desires are satisfied, the time interval during which you benefit is the time of the desire; and, when future-directed desires are satisfied, the time interval during which you benefit is the time of the object. In this essay, I argue that Asymmetrism (...) forces us to give implausible answers to a different question: To what extent does a given satisfied desire benefit you? (shrink)

This work treats the correlative concepts knowledge and opinion, in various senses. In all senses of ‘knowledge’ and ‘opinion’, a belief known to be true is knowledge; a belief not known to be true is opinion. In this sense of ‘belief’, a belief is a proposition thought to be true—perhaps, but not necessarily, known to be true. All knowledge is truth. Some but not all opinion is truth. Every proposition known to be true is believed to be true. Some but (...) not every proposition believed to be true is known to be true. Our focus is thus on propositional belief (“belief-that”): the combination of propositional knowledge (“knowledge-that”) and propositional opinion (“opinion-that”). Each of a person’s beliefs, whether knowledge or opinion, is the end result of a particular thought process that continued during a particular time interval and ended at a particular time with a conclusive act—a judgment that something is the case. This work is mainly about beliefs in substantive informative propositions—not empty tautologies. We also treat objectual knowledge (knowledge of objects in the broadest sense, or “knowledge-of”), operational knowledge (abilities and skills, “knowledge-how-to”, or “know-how”), and expert knowledge (expertise). Most points made in this work have been made by previous writers, but to the best of our knowledge, they have never before been collected into a coherent work accessible to a wide audience. -/- Key words: belief, knowledge/opinion, propositional, operational, objectual, cognition, . (shrink)

Trust has a great potential for furthering our understanding of organizational change and learning. This potential however remains largely untapped. It is argued that two reasons as for why this potential remains unrealized are: (i) A narrow conceptualization of change as implementation and (ii) an emphasis on direct and aggregated effects of individual trust to the exclusion of other effects. It is further suggested that our understanding of the effects of trust on organizational change, should benefit from including effects of (...) trust on the formulation stage. It should also benefit from exploring the structuring effects of trust in organizations. Throughout this chapter, ways to extend current research on trust in organizations are suggested. The chapter also provides examples of relevant contributions where available. In order to capture organizational effects of trust, it is suggested that trust should be studied over longer time intervals, and include several referents of trust, spanning both horizontal and vertical relationships in the organization. (shrink)

The word ‘equality’ often requires disambiguation, which is provided by context or by an explicit modifier. For each sort of magnitude, there is at least one sense of ‘equals’ with its correlated senses of ‘is greater than’ and ‘is less than’. Given any two magnitudes of the same sort—two line segments, two plane figures, two solids, two time intervals, two temperature intervals, two amounts of money in a single currency, and the like—the one equals the other or (...) the one is greater than the other or the one is greater than the other [sc. in appropriate correlated senses of ‘equals’, ‘is greater than’ and ‘is less than’]. In case there are two or more appropriate senses of ‘equals’, the one intended is often indicated by an adverb. For example, one plane figure may be said to be equal in area to another and, in certain cases, one plane figure may be said to be equal in length to another. Each sense of ‘equality’ is tied to a specific domain and is therefore non-logical. Notice that in every cases ‘equality’ is definable in terms of ‘is greater than’ and also in terms of ‘is less than’ both of which are routinely considered domain specific, non-logical. The word ‘identity’ in the logical sense does not require disambiguation. Moreover, it is not correlated ‘is greater than’ and ‘is less than’. If it is not the case that a certain designated triangle is [sc. is identical to] an otherwise designated triangle, it is not necessary for the one to be greater than or less than the other. Moreover, if two magnitudes are equal then a unit of measure can be chosen and, no matter what unit is chosen, each magnitude is the same multiple of the unit that the other is. But identity does not require units. In this regard, congruence is like identity and unlike equality. In arithmetic, the logical concept of identity is coextensive with the arithmetic concept of equality. The logical concept of identity admits of an analytically adequate definition in terms of logical concepts: given any number x and any number y, x is y iff x has every property that y has. The arithmetical concept of equality admits of an analytically adequate definition in terms of arithmetical concepts: given any number x and any number y, x equals y iff x is neither less than nor greater than y. As Aristotle told us and as Frege retold us, just because one relation is coextensive with another is no reason to conclude that they are one. (shrink)

When disability-adjusted life years are used to measure the burden of disease on a population in a time interval, they can be calculated in several different ways: from an incidence, pure prevalence, or hybrid perspective. I show that these calculation methods are not equivalent and discuss some of the formal difficulties each method faces. I show that if we don’t discount the value of future health, there is a sense in which the choice of calculation method is a mere (...) question of accounting. Such questions can be important, but they don’t raise deep theoretical concerns. If we do discount, however, choice of calculation method can change the relative burden attributed to different conditions over time. I conclude by recommending that studies involving disability-adjusted life years be explicit in noting what calculation method is being employed and in explaining why that calculation method has been chosen. (shrink)

Trust has a great potential for furthering our understanding of organizational change and learning. This potential however remains largely untapped. It is argued that two reasons as for why this potential remains unrealized are: (i) A narrow conceptualization of change as implementation and (ii) an emphasis on direct and aggregated effects of individual trust to the exclusion of other effects. It is further suggested that our understanding of the effects of trust on organizational change, should benefit from including effects of (...) trust on the formulation stage. It should also benefit from exploring the structuring effects of trust in organizations. Throughout this chapter, ways to extend current research on trust in organizations are suggested. The chapter also provides examples of relevant contributions where available. In order to capture organizational effects of trust, it is suggested that trust should be studied over longer time intervals, and include several referents of trust, spanning both horizontal and vertical relationships in the organization. (shrink)

In humans, knowing the world occurs through spatial-temporal experiences and interpretations. Conscious experience is the direct observation of conscious events. It makes up the content of consciousness. Conscious experience is organized in four dimensions. It is an orientation in space and time, an understanding of the position of the observer in space and time. A neural correlate for four-dimensional conscious experience has been found in the human brain which is modeled by Einstein’s Special Theory of Relativity. Spacetime (...) class='Hi'>intervals are fundamentally involved in the organization of coherent conscious experiences. They account for why conscious experience appears to us the way it does. They also account for assessment of causality and past-future relationships, the integration of higher cognitive functions, and the implementation of goal-directed behaviors. Spacetime intervals in effect compose and direct our conscious life. The relativistic concept closes the explanatory gap and solves the hard problem of consciousness (how something subjective like conscious experience can arise in something physical like the brain). There is a place in physics for consciousness. We describe all physical phenomena through conscious experience, whether they be described at the quantum level or classical level. Since spacetime intervals direct the formation of all conscious experiences and all physical phenomena are described through conscious experience, the equation formulating spacetime intervals contains the information from which all observable phenomena may be deduced. It might therefore be considered expression of a theory of everything. (shrink)

This is a paper dealing with methodological and foundational issues in the realm of Futures Studies. It provides possible metrics for the temporal coordinate in the cone of plausibility. As a consequence, some scales to classify levels of future with respect to a certain time interval relevant to measure the future of humanity are suggested.

Most philosophers believe that we have experiences as of temporally extended phenomena like change, motion, and succession. Almost all theories of time consciousness explain these temporal experiences by subscribing to the doctrine of the specious present, the idea that the contents of our experiences embrace temporally extended intervals of time and are presented as temporally structured. Against these theories, I argue that the doctrine is false and present a theory that does not require the notion of a (...) specious present. Furthermore, I argue that the different aspects of temporal experiences arise from different mechanisms operating separately. If the theory is true, then temporal experiences do not tell us anything special about the nature of consciousness and its temporal properties per se. (shrink)

Conscious experience is the direct observation of conscious events. Human conscious experience is four-dimensional. Conscious events are linked (associated) by spacetime intervals to produce a coherent conscious experience. This explains why conscious experience appears to us the way it does. Conscious experience is an orientation in space and time, an understanding of the position of the observer in space and time. Causality, past-future relations, learning, memory, cognitive processing, and goal-directed actions all evolve from four-dimensional conscious experience. A (...) neural correlate for four-dimensional conscious experience can be found in the human brain and is modelled by Einstein's special theory of relativity. The relativistic concept of spacetime interval is central for understanding conscious experience and cognition. (shrink)

The philosophical investigation of perceptual illusions can generate fruitful insights in the study of subjective time consciousness. However, the way illusions are interpreted is often controversial. Recently, proponents of the so-called dynamic snapshot theory have appealed to the Waterfall Illusion, a kind of motion aftereffect, to support a particular view of temporal consciousness according to which experience is structured as a series of instantaneous snapshots with dynamic qualities. This dynamism is meant to account for familiar features of the phenomenology (...) of time, such as succession, continuity, and change. Previous theories have typically appealed to a subjective present occupying an interval of time; that is, a “specious present.” I argue, through analysis of motion aftereffect illusions and the rare condition of akinetopsia, i.e. motion-blindness, that the Waterfall Illusion fails to support the dynamic snapshot theory as intended. Furthermore, I suggest that future theories of subjective time should see temporal phenomenology as the result of non-localised processes closely tied to the mechanism underlying consciousness generally. (shrink)

In this article we provide a mathematical model of Kant?s temporal continuum that satisfies the (not obviously consistent) synthetic a priori principles for time that Kant lists in the Critique of pure Reason (CPR), the Metaphysical Foundations of Natural Science (MFNS), the Opus Postumum and the notes and frag- ments published after his death. The continuum so obtained has some affinities with the Brouwerian continuum, but it also has ‘infinitesimal intervals’ consisting of nilpotent infinitesimals, which capture Kant’s theory (...) of rest and motion in MFNS. While constructing the model, we establish a concordance between the informal notions of Kant?s theory of the temporal continuum, and formal correlates to these notions in the mathematical theory. Our mathematical reconstruction of Kant?s theory of time allows us to understand what ?faculties and functions? must be in place for time to satisfy all the synthetic a priori principles for time mentioned. We have presented here a mathematically precise account of Kant?s transcendental argument for time in the CPR and of the rela- tion between the categories, the synthetic a priori principles for time, and the unity of apperception; the most precise account of this relation to date. We focus our exposition on a mathematical analysis of Kant’s informal terminology, but for reasons of space, most theorems are explained but not formally proven; formal proofs are available in (Pinosio, 2017). The analysis presented in this paper is related to the more general project of developing a formalization of Kant’s critical philosophy (Achourioti & van Lambalgen, 2011). A formal approach can shed light on the most controversial concepts of Kant’s theoretical philosophy, and is a valuable exegetical tool in its own right. However, we wish to make clear that mathematical formalization cannot displace traditional exegetical methods, but that it is rather an exegetical tool in its own right, which works best when it is coupled with a keen awareness of the subtleties involved in understanding the philosophical issues at hand. In this case, a virtuous ?hermeneutic circle? between mathematical formalization and philosophical discourse arises. (shrink)

In the light of the results obtained during the last two decades in analysis of signals by time series, it has become evident that the tools of non linear dynamics have their elective role of application in biological, and, in particular, in neuro-physiological and psycho-physiological studies. The basic concept in non linear analysis of experimental time series is that one of recurrence whose conceptual counterpart is represented from variedness and variability that are the foundations of complexity in dynamic (...) processes. Thus, the recurrence plots and the Recurrence Quantification Analysis (RQA) are discussed. It is shown that RQA represents the most general and correct methodology in investigation of experimental time series. By it we arrive to inspect the inner structure of the time series connected to the signals under investigation. Linked to RQA we prospect also the method CZF, recently introduced by us. It is able to account for a true estimation of variability of signals in time as well as in frequency domain. And, consequently, it may be used in conjunction with classical Fourier analysis, accounting however that it is inappropriate in analysis of non linear and non stationary experimental time series. The use of CZF method in fractal analysis is also considered in addition to standard index as Hurst exponent. A large field of possible applications in neurological as well as in psycho-physiological studies is given. Also, there are given examples of other and (possibly linked) applications as example the analysis of beat-to-beat fluctuations of human heartbeat intervals that is sovereign in psycho-physiological studies. We give applications on some different planes to evidence the particular sensitivity of such methods. We reach the objective to show that the previously exposed methods are also able to predict in advance the advent of ventricular tachycardia and/or of ventricular fibrillation. The RQA analysis gives good results. The CZF method gives the most excellent results showing that it is able to give very significant indexes of prediction. We also apply such methods in investigation of state anxiety, and proposing in detail a quantum like model of such phenomenological status of the mind. (shrink)

K denotes both the knowledge predicate satisfied by every currently known theorem and the finite set of all currently known theorems. The set K is time-dependent, publicly available, and contains theorems both from formal and constructive mathematics. Any theorem of any mathematician from past or present forever belongs to K. Mathematical statements with known constructive proofs exist in K separately and form the set K_c⊆K. We assume that mathematical sets are atemporal entities. They exist formally in ZFC theory although (...) their properties can be time-dependent (when they depend on K) or informal. The true statement "K is non-empty" is outside K forever because K is not a formal set. Paul Cohen proved in 1963 that the equality 2^{\aleph_0}=\aleph_1 is independent of ZFC. Before 1963, the statement "There is a known constructively defined integer n⩾1 such that 2^{\aleph_0}=\aleph_n" was outside K. Since 1963, this statement is outside K forever. The true statement "There exists a set X⊆{1,...,49} such that card(X)=6 and X never occurred as the winning six numbers in the Polish Lotto lottery" refers to the current non-mathematical knowledge and is outside K forever. In Martin-Löf's terminology, every currently known theorem is actually true whereas every theorem (known or unknown) is potentially true. Actual truth is knowledge dependent and tensed. Potential truth is knowledge independent and tenseless. Algorithms always terminate. We explain the distinction between algorithms whose existence is provable in ZFC and constructively defined algorithms which are currently known. By using this distinction, we obtain non-trivially true statements on decidable sets X⊆N that belong to constructive and informal mathematics and refer to the current mathematical knowledge on X. For every such statement, its truth concerning the current mathematical knowledge is implied by a true statement of the form: (the conjunction of i conditions of the form α∈K)∧(the conjunction of j conditions of the form β∉K)∧(the conjunction of k conditions of the form γ∈K_c)∧(the conjunction of l conditions of the form δ∉K_c), where i,j,k,l∈N and α,β,γ,δ are mathematical statements. In constructive mathematics and the traditional Brouwerian intuitionism, the truth of a mathematical statement means that we know a constructive proof. Therefore, the truth of a mathematical statement depends on time, where the statement is formally stated in the classical mathematics without the predicate K. In this article, mathematical statements on decidable sets X⊆N refer to time because they refer to the current mathematical knowledge on X. They cannot be formally stated in the classical mathematics without the predicate K and their logical values may change in time. For a set X⊆N whose infiniteness is false or unproven, we define which elements of X are classified as known. No known set X⊆N satisfies Conditions (1)-(4) and is widely known in number theory or naturally defined, where this term has only informal meaning. (1) A known algorithm with no input returns an integer n satisfying card(X)<ω ⇒ X⊆(-∞,n]. (2) A known algorithm for every k∈N decides whether or not k∈X. (3) For every known algorithm A with no input, the statement "A returns the logical value of the statement card(X)=ω" is outside K. (4) There are many elements of X and it is conjectured, though so far unproven, that X is infinite. (5) X is naturally defined. The infiniteness of X is false or unproven. X has the simplest definition among known sets Y⊆N with the same set of known elements. No set X⊆N will satisfy Conditions (1)-(4) forever, if for every algorithm with no input, at some future day, a computer will be able to execute this algorithm in 1 second or less. The physical limits of computation disprove the assumption of the above statement. We prove that the set X={n∈N: the interval [-1,n] contains more than 29.5+(11!/(3n+1))∙sin(n) primes of the form k!+1} satisfies Conditions (1)-(5) except the requirement that X is naturally defined. We present a table that shows satisfiable conjunctions of the form #(Condition1)∧(Condition 2)∧#(Condition 3)∧(Condition 4)∧#(Condition 5), where # denotes the negation ¬ or the absence of any symbol. We prove that there exists a naturally defined set C⊆N which satisfies the following conditions (6)-(11). (6) A known and simple algorithm for every k∈N decides whether or not k∈C. (7) For every known algorithm A with no input, the statement "A returns the logical value of the statement card(C)=ω" is outside K. (8) For every known algorithm A with no input, the statement "A returns the logical value of the statement card(N\C)=ω" is outside K. (9) It is conjectured, though so far unproven, that C is infinite. (10) For every known algorithm A with no input, the statement "A returns an integer n satisfying card(C)<ω ⇒ C⊆(-∞,n]" is outside K. (11) For every known algorithm A with no input, the statement "A returns an integer m satisfying card(N\C)<ω ⇒ N\C⊆(-∞,m]" is outside K. The set C={k∈N: 2^{2^k}+1 is composite} is naturally defined and satisfies conditions (6)-(11). (shrink)

Neutrosophic Over-/Under-/Off-Set and -Logic were defined for the first time by Smarandache in 1995 and published in 2007. They are totally different from other sets/logics/probabilities. He extended the neutrosophic set respectively to Neutrosophic Overset {when some neutrosophic component is > 1}, Neutrosophic Underset {when some neutrosophic component is < 0}, and to Neutrosophic Offset {when some neutrosophic components are off the interval [0, 1], i.e. some neutrosophic component > 1 and other neutrosophic component < 0}. This is no surprise (...) with respect to the classical fuzzy set/logic, intuitionistic fuzzy set/logic, or classical/imprecise probability, where the values are not allowed outside the interval [0, 1], since our real-world has numerous examples and applications of over-/under-/off-neutrosophic components. (shrink)

In temporal binding, the temporal interval between one event and another, occurring some time later, is subjectively compressed. We discuss two ways in which temporal binding has been conceptualized. In studies showing temporal binding between a voluntary action and its causal consequences, such binding is typically interpreted as providing a measure of an implicit or pre-reflective “sense of agency”. However, temporal binding has also been observed in contexts not involving voluntary action, but only the passive observation of a cause-effect (...) sequence. In those contexts, it has been interpreted as a top-down effect on perception reflecting a belief in causality. These two views need not be in conflict with one another, if one thinks of them as concerning two separate mechanisms through which temporal binding can occur. In this paper, we explore an alternative possibility: that there is a unitary way of explaining temporal binding both within and outside the context of voluntary action as a top-down effect on perception reflecting a belief in causality. Any such explanation needs to account for ways in which agency, and factors connected with agency, have been shown to affect the strength of temporal binding. We show that principles of causal inference and causal selection already familiar from the literature on causal learning have the potential to explain why the strength of people’s causal beliefs can be affected by the extent to which they are themselves actively involved in bringing about events, thus in turn affecting binding. (shrink)

The monograph presents the ideas about the main changes that occurred in the development of technologies from the emergence of Homo sapiens till present time and outlines the prospects of their development in the next 30–60 years and in some respect until the end of the twenty-first century. What determines the transition of a society from one level of development to another? One of the most fundamental causes is the global technological transformations. Among all major technological breakthroughs in history (...) the most important are three production revolutions: 1) the Agrarian Revolution; 2) the Industrial Revolution; and 3) the Cybernetic one. The book introduces the theory of production revolutions which is a new valuable explanatory paradigm that analyzes causes and trends of dramatic shifts in historical process. The authors describe the course of technological transformations in history and demonstrate a possible application of the theory to explain the present and forthcoming technological changes. They analyze the technological shifts which took place in the second half of the twentieth and early twenty-first centuries and forecast the main shifts in the next half a century. On this basis the authors present a detailed analysis of the latest production revolution which is denoted as ‘Сybernetic’. They make some predictions about its development in the nearest five decades and up to the end of the twenty-first century and show that the development of various self-regulating systems will be the main trend of this revolution. The authors argue that the transition to the starting final phase of the Cybernetic Revolution (in the 2030–2040s) will first occur in the field of medicine (in some its innovative branches). In future we will deal with the started convergence of innovative technologies which will form the system of MANBRIC-technologies (i.e. the technological paradigm based on medicine, additive, nano- and bio- technologies, robotics, IT and cognitive technologies). The monograph gives an outline of the future breakthroughs in medicine and some other technologies (between the 2010s and 2070s). (shrink)

We present in this paper a novel ontological theory of events whose central tenet is the Aristotelian distinction between the object that changes and the actual subject of change, which is what we call an individual quality. While in the Kimian tradition events are individuated by a triple ⟨ o, P, t ⟩, where o is an object, P a property, and t an interval of time, for us the simplest events are qualitative changes, individuated by a triple ⟨ (...) o, q, t ⟩, where q is an individual quality inhering in o or in one of its parts. Detaching the individuation of events from the property they exemplify results in a fine-grained theory that keeps metaphysics and semantics clearly separate, and lies between the multiplicative and the unitarian approaches. We discuss then the way language refers to events, observing that, in most cases, event descriptions refer to complex, cognitively relevant clusters of co-occurring qualitative changes, which exhibit a synchronic structure depending on the way they are described. Contra Bennett, who famously argued that the semantics of event names ultimately depends on “local context and unprincipled intuitions”, we show how the lexicon provides systematic principles for individuating such clusters and classifying them into kinds. Finally, we address some open challenges in the semantics of locative and manner modifiers. (shrink)

I examine the reasons Aristotle presents in Physics VIII 8 for denying a crucial assumption of Zeno’s dichotomy paradox: that every motion is composed of sub-motions. Aristotle claims that a unified motion is divisible into motions only in potentiality (δυνάμει). If it were actually divided at some point, the mobile would need to have arrived at and then have departed from this point, and that would require some interval of rest. Commentators have generally found Aristotle’s reasoning unconvincing. Against David Bostock (...) and Richard Sorabji, inter alia, I argue that Aristotle offers a plausible and internally consistent response to Zeno. I defend Aristotle’s reasoning by using his discussion of what to say about the mobile at boundary instants, transitions between change and rest. There Aristotle articulates what I call the Changes are Open, Rests are Closed Rule: what is true of something at a boundary instant is what is true of it over the time of its rest. By contrast, predications true of something over its period of change are not true of the thing at either of the boundary instants of that change. I argue that this rule issues from Aristotle’s general understanding of change, as laid out in Phys. III. It also fits well with Phys. VI, where Aristotle maintains that there is a first boundary instant included in the time of rest, but not a “first in which the mobile began to change.” I then show how this rule underlies Aristotle’s argument that a continuous motion cannot be composed of actual sub-motions. Aristotle distinguishes potential middles, points passed through en route to a terminus, from actual middles. The Changes are Open, Rests are Closed Rule only applies to actual middles, because only they are boundaries of change that the mobile must arrive at and then depart from. On my reading, Aristotle argues that the instant of arrival, the first instant at which the mobile has come to be at the actual middle, cannot belong to the time of the subsequent motion. If it did, the mobile would already be moving towards the next terminus and thus, per Phys. VI 6, would have already left. But it cannot have moved away from the midpoint at the very same moment it has arrived there. This means that the instant of arrival must be separated from the time of departure by an interval of rest. I show how Aristotle’s reasoning applies generally to rule out any continuous reflexive motion or continuous complex rectilinear motion. On my interpretation, however, the argument does not apply to every change of direction. When, as in the case of projectile motion, multiple movers and their relative powers explain why the mobile changes directions, distinct sub-motions are not involved. Aristotle holds that such motions cannot be continuous, not because they involve intervals of rest, but because they involve multiple causes of motion. My interpretation of the Changes are Open, Rests are Closed Rule allows us to make better sense of Aristotle’s argument than any previous interpretation. (shrink)

Nanotechnology, as with many technologies before it, places a strain on existing legislation and poses a challenge to all administrative agencies tasked with regulating technology-based products. It is easy to see how statutory schemes become outdated, as our ability to understand and affect the world progresses. In this article, we address the regulatory problems that nanotechnology posses for the Food and Drug Administration’s (FDA) classification structure for ‘‘drugs’’ and ‘‘devices.’’ The last major modification to these terms was in 1976, with (...) the enactment of the Medical Device Amendments. There are serious practical differences for a classification as a drug or device in terms of time to market and research. Drugs are classified, primarily, as acting by ‘‘chemical action.’’ We lay out some legal, philosophic, and scientific tools that serve to provide a useful, as well as legally and scientifically faithful, distinction between drugs and devices for the purpose of regulatory classification. These issues we raise are worth the consideration of anyone who is interested in the regulation of nano-products or other novel technologies. (shrink)

The paper introduces measurement of fixation-speech intervals as an important tool for the study of the reading process. Using the theory of the organism-environment system, we developed experiments to investigate the time course of reading. By combining eye tracking with synchronous recording of speech during reading in a single measure, we issue a fundamental challenge to information processing models. Not only is FSI an authentic measure of the reading process, but it shows that we exploit verbal patterns, textual (...) features and, less directly, reading experience. Reading, we conclude, is not a matter of decoding linguistic information. Far from being a text-driven process, it depends on integrating both sensory and motor processes in an anticipatory meaning generation based on the history of experience and cultural context of the reader. Finally, we conclude with remarks on the social character and cognitive history of reading. (shrink)

We propose an ontological theory that is powerful enough to describe both complex spatio-temporal processes and the enduring entities that participate therein. For this purpose we introduce the notion a directly depicting ontology. Directly depicting ontologies are based on relatively simple languages and fall into two major categories: ontologies of type SPAN and ontologies of type SNAP. These represent two complementary perspectives on reality and employ distinct though compatible systems of categories. A SNAP (snapshot) ontology comprehends enduring entities such as (...) organisms, geographic features, or qualities as they exist at some given moment of time. A SPAN ontology comprehends perduring entities such as processes and their parts and aggregates as they unfold themselves through some temporal interval. We give an axiomatic account of the theory of directly depicting ontologies and of the core parts of the metaontological fragment within which they are embedded. (shrink)

We have defined the Neutrosophic Over- /Under-/Off-Set and -Logic for the first time in 1995 and published in 2007. During 1995-2016 we presented them to various national and international conferences and seminars ([16]-[37]) and did more publishing during 2007-2016 ([1]-[15]). These new notions are totally different from other sets/logics/probabilities. We extended the neutrosophic set respectively to Neutrosophic Overset {when some neutrosophic component is > 1}, to Neutrosophic Underset {when some neutrosophic component is < 0}, and to Neutrosophic Offset {when (...) some neutrosophic components are off the interval [0, 1], i.e. some neutrosophic component > 1 and other neutrosophic component < 0}. This is no surprise since our real-world has numerous examples and applications of over-/under-/off-neutrosophic components. (shrink)

This essay explores Kaila's interpretation of the special theory of relativity. Although the relevance of his work to logical empiricism is well-known, not much has been written on what Kaila calls the ‘Einstein-Minkowski invariance theory’. Kaila's interpretation focuses on two salient features. First, he emphasizes the importance of the invariance of the spacetime interval. The general point about spacetime invariance has been known at least since Minkowski, yet Kaila applies his overall tripartite theory of invariances to space, time and (...) spacetime in an original way. Second, Kaila provides a non-conventionalist argument for the isotropic speed of electromagnetic signals. The standard Einstein synchrony is not a mere convention but a part of a larger empirical theory. According to Kaila's holistic principle of testability, which stands in contrast to the theses of translatability and verification, different items in the theory cannot be sharply divided into conventional and empirical. Kaila's invariantism/non-conventionalism about relativity reflects an interesting case in the gradual transition from positivism to realism within the philosophy of science. (shrink)

Hájek has recently presented the following paradox. You are certain that a cable guy will visit you tomorrow between 8 a.m. and 4 p.m. but you have no further information about when. And you agree to a bet on whether he will come in the morning interval (8, 12] or in the afternoon interval (12, 4). At first, you have no reason to prefer one possibility rather than the other. But you soon realise that there will definitely be a future (...) time at which you will (rationally) assign higher probability to an afternoon arrival than a morning one, due to time elapsing. You are also sure there may not be a future time at which you will (rationally) assign a higher probability to a morning arrival than an afternoon one. It would therefore appear that you ought to bet on an afternoon arrival. The paradox is based on the apparent incompatibility of the principle of expected utility and principles of diachronic rationality which are prima facie plausible. Hájek concludes that the latter are false, but doesn't provide a clear diagnosis as to why. We endeavour to further our understanding of the paradox by providing such a diagnosis. (shrink)

RESUMO A bovinocultura sempre esteve atrelada ao desenvolvimento do Brasil e, pensando no avanço, as exigências da máxima eficiência nos sistemas de criação foi pautada na forma de como conseguir realizar a reprodução de bovinos com ênfase na eficiência econômica e reprodutiva. O objetivo deste trabalho é elucidar as principais biotecnologias que auxiliam na maior produtividade reprodutiva de bovinos. Dessa forma, o estudo foi realizado usando artigos do banco de dados do Google acadêmico e SciELO, além de livros do acervo (...) pessoal e sites oficiais. Com o manejo reprodutivo aplicado na bovinocultura, é possível identificar pontos a serem melhorados e implantação de práticas que auxiliam no incremento da eficiência reprodutiva como a estação de monta, que concentra a fertilização dos animais em uma determinada época do ano, o uso do índice de escore corporal, o qual consegue determinar a viabilidade da vaca a ser fertilizada, e a identificação da idade a puberdade, na qual a novilha com 60% de peso vivo quando adulta pode estar apta para reprodução, indicando que a nutrição é um fator importante para reduzir o intervalo entre partos, bem como na indução da precocidade, que ainda pode ser maximizada por uso de bioestimuladores. Assim como a implantação do uso de biotecnologias, que podem adicionar aos planteis, indivíduos geneticamente superiores, saudáveis e eficientes. Dentre as biotecnologias, a inseminação artificial é a mais usada no Brasil, com capacidade de fertilizar vacas com sêmen de touros de genética superior, nacional ou importado. Podem ser citadas ainda as técnicas de transferência de embriões e produção in vitro de embriões como tecnologias a serviço do desenvolvimento da eficiência reprodutiva. A utilização de protocolos hormonais no ciclo estral objetiva a sincronização do estro das vacas para facilitar o emprego das biotecnologias. São vários os protocolos usados para essa finalidade, sendo Ovsynch a base de GnRH e prostaglandina com até 50% de eficácia, protocolos à base de estradiol e progesterona com eficácia de até 86,6%, e protocolos que usam gonadotrofina coriônica equina (eCG), indicados para animais magros por condicionar maior diâmetro folicular, o qual é relacionado com aumento na taxa de prenhez. Dessa maneira, as práticas e tecnologias citadas neste estudo são usadas na reprodução assistida de bovinos. PALAVRAS-CHAVE: Criopreservação. Estro. Gestação. Hipófise. Nutrição. ABSTRACT Cattle farming has always been linked to Brazil’s development and, thinking about advancement, the requirements for maximum efficiency in breeding systems was based on how to achieve the reproduction of cattle with an emphasis on economic and reproductive efficiency. The objective of this work is to elucidate the main biotechnologies that help in the greater reproductive productivity of cattle. Thus, the study was done using articles from the Academic Google and SciELO databases, as well as books from the personal collection and official websites. With the reproductive management applied in cattle farming, it is possible to identify points to be improved and implement practices that help to increase reproductive efficiency, such as the breeding season, which concentrates the fertilization of animals at a certain time of year, use of the body score index, which can determine the viability of the cow to be fertilized, identification of age at puberty, in which the heifer with 60% live weight as an adult may be suitable for reproduction, indicating that nutrition is an important factor in reducing the interval between births, as well as in inducing precocity, which can still be maximized by the use of biostimulators. As well as the implementation of the use of biotechnology, which can add genetically superior, healthy and efficient individuals to the breeding stock. Among the biotechnologies, artificial insemination is the most used in Brazil, with the capacity to fertilize cows with superior genetic bull semen, whether national or imported. Embryo transfer techniques and in vitro embryo production can also be cited as technologies in the service of the development of reproductive efficiency. The use of hormonal protocols in the estrous cycle aims at synchronizing the estrus of cows to facilitate the use of biotechnologies. There are several protocols used for this purpose, with Ovsynch being based on GnRH and prostaglandin with up to 50% efficacy, protocols based on estradiol and progesterone with efficacy of up to 86.6%, and protocols that use equine chorionic gonadotropin (eCG), indicated for lean animals because they condition larger follicular diameter, which is related to an increase in the pregnancy rate. Thus, the practices and technologies mentioned in this study can help the assisted reproduction of cattle. KEYWORDS: Cryopreservation. 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BARBOSA, F.A. et al. Produtividade e eficiência econômica de sistemas de produção de cria, recria e engorda de bovinos de corte na região sul do estado da Bahia. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 62, p. 677-685, 2010. BARBOSA, R.T.; MACHADO, R. Panorama da inseminação artificial em bovinos. Embrapa Pecuária Sudeste-Documentos (INFOTECA-E), 2008. BARREIROS, T.R.R. et al. Dynamics of follicular growth and progesterone concentrations in cyclic and anestrous suckling Nelore cows (Bos indicus) treated with progesterone, equine chorionic gonadotropin, or temporary calf removal. Theriogenology, v. 81, n. 5, p. 651-656, 2014. BARUSELLI, P.S. et al. Evolução e perspectivas da inseminação artificial em bovinos. Revista Brasileira de Reprodução Animal, v. 43, n. 2, p. 308-314, 2019. BATISTELLA, M. et al. Geotecnologias e gestão territorial da bovinocultura no Brasil. Revista Brasileira de Zootecnia, v. 40, p. 251-260, 2011. BERLITZ, C.G.B. 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Grenon and Smith (2004) propose a framework for the ontology of things in space and time involving and invoking the distinction between continuants and occurrents, which has become a key element of Basic Formal Ontology (BFO). The terminology of SNAP (from “snapshot:” state of a continuant at a time) and SPAN (how an occurrent develops over an interval or timespan) occurs in that paper’s title. While any commonsense ontology will have a place for both continuants and occurrents, there (...) is much room for philosophical debate on whether one of them is more basic than the other, or can be reduced to the other, or whether they are equally fundamental, or whether they are two different perspectives on the same reality. Grenon and Smith opt for the last of these. They call the accounts of continuants (SNAP) and occurrents (SPAN) both “ontologies.” They do not have a single ontology of all that is in space and time. This dialog throws a few of the common arguments around a bit and comes to no sure conclusion. But one of the characters bears a faint resemblance to a certain Buffalonian philosopher. (shrink)

The present study examines the physiological alterations in prolactin (PRL) messenger ribonucleic acid (mRNA) and serum PRL levels during the rat estrous cycle and the effed of naloxone, an endogenous opioid peptide receptor antagonist, on PRL gene expression during the rat estrous cycle. Adult female rats exhibiting at least two consecutive 4-day estrous cycles were used in this study. A single injection of naloxone (2mg/kg b.w.) or saline was given sc 30 mm prior to decapitation. Animals were sacrificed at 10:00 (...) h of each stage of the estrous cycle, and at 2-h intervals from 10:00 h to 20:00 h during the proestrus. PRL mRNA and serum PRL levels were determined by an RNA-blot hybridization with the rat PRL cDNA probe and by a PRL radioimmunoassay, respectively. PRL mRNA and serum PRL levels were not dramatically altered in the morning of each stage of diestrus I, II, and proestrus, and naloxone failed to modify the two parameters. During estrus naloxone clearly suppressed serum PRL levels, but it was unable to modify PRL mRNA levels. A more detailed examination of the proestrus stage revealed that PRL mRNA and serum PRL levels fluctuated as a function of time: PRL mRNA levels reached a maximum level at 12:00 h and gradually decreased until 18:00 h. PRL mRNA levels then rose at 20:00 h. No difference in PRL mRNA levels between the control and naloxone-treated groups was observed. Changes in serum PRL level during proestrus were conversely related to changes in PRL mRNA: serum PRL levels were low from 10:00 h to 14:00 h, then increased and reached a maximum level at 16:00-18:00 h. Following then, serum PRL levels were decreased. Naloxone was effective in suppressing the characteristic afternoon surge of PRL from 16:00 h to 20:00 h. These data clearly showed that alterations in PRL mRNA levels were conversely correlated with changes in serum PRL levels on proestrus, indicating differential regulation of PRL gene expression and secretion. (shrink)

In this book, for the first time, authors try to introduce the concept of linguistic variables as a continuum of linguistic terms/elements/words in par or similar to a real continuum. For instance, we have the linguistic variable, say the heights of people, then we place the heights in the linguistic continuum [shortest, tallest] unlike the real continuum (–∞, ∞) where both –∞ or +∞ is only a non-included symbols of the real continuum, but in case of the linguistic continuum (...) we generally include the ends or to be more mathematical say it is a closed interval, where shortest denotes the shortest height of a person, maybe the born infant who is very short from usual and the tallest will denote the tallest one usually very tall; however this linguistic continuum [shortest, tallest] in the real continuum will be the closed interval say [1 foot, 8 feet] or [1, 8] the measurement in terms of feet. So, the real interval is a subinterval with which we have associated the real continuum in terms of qualifying unit feet and inches in this case. (shrink)

This paper exploits the fact that the variability in the inter-spike intervals, in the spike train issuing from a neuron, carries substantial information regarding the input to the neuron. A framework for neuronal information processing is proposed which utilizes the above fact to distinguish phenomenal from non-phenomenal mental representation. In the process, an explanation is offered as to what is it, in the nature of conscious mental states, that imparts them a subjective feeling – there is something it is (...) like to be in those mental states. To give empirical support, it is shown how the proposed framework can neatly explain, the delay in eliciting conscious awareness as observed by Libet and the related backwards referral in time. (shrink)