Frege argued for the force-content distinction not only by appealing to the logical and fictional contexts which are most closely associated with the “Frege point", but also based on the fact that an affirmative answer to a yes-no question constitutes an assertion. Supposedly this is only intelligible if the question contains a forceless thought or proposition which an affirmative answer then asserts. Against this I argue that this fact more readily supports the view that questions operate on assertions and other (...) forceful acts themselves. Force is neither added to propositions as on the traditional view, nor is it cancelled as has recently been proposed. Rather higher-level acts such as questioning, but also e.g. conditionalizing, embed and present assertoric or directive acts that are forceful and committal, while suspending commitment to them. The Frege point confounds different varieties of force and the question whether something is merely presented for consideration with the question what is so presented. Force is representational: through assertoric and directive force indicators subjects non-conceptually present positions of theoretical or practical knowledge, while interrogative acts indicate positions of wondering which strive for such knowledge. (shrink)

This paper argues that to account for group speech acts, we should adopt a representationalist account of mode / force. Individual and collective subjects do not only represent what they e.g. assert or order. By asserting or ordering they also indicate their theoretical or practical positions towards what they assert or order. The ‘Frege point’ cannot establish the received dichotomy of force and propositional content. On the contrary, only the representationalist account allows a satisfactory response to it. It also allows (...) us to give a more satisfactory analysis of the speech act of inviting a joint commitment and to answer two important questions Bernhard Schmid has raised about group speech acts, namely whether there are 1st person plural forms of Moore’s paradox and of 1st person authority. (shrink)

Raimo Tuomela’s most important contribution to the philosophy of collective intentionality was his development of the notion of the we-mode. In my chapter I extend the notion of we-mode to that of role-mode, the mode in which individual and collective subjects feel, think and act as occupants of roles within groups and institutional structures. I focus on how being in role-mode is manifest in the minds of subjects and on the following points. First, I argue that both we-mode and role-mode (...) are best thought of as further modifications of I-consciousness, respectively we-consciousness. Second, role-mode is further characterized by the fact that subjects will take positions as role occupants that they won’t take as mere individuals, or we-mode group members, or in other roles. Third, such divergences are only possible against a background of agreements between positions taken in different modes. Fourth, such divergences are also grounded in decision making procedures and the accessibility and admissibility of sources of evidence. Fifth, role-mode goes all the way down, that is, it is also manifest in how subjects feel, move and comport themselves when they occupy their roles. To put it into fashionable jargon, it is embodied and enacted. (shrink)

In this paper I outline the PAIR account of joint attention as a perceptual-practical, affectively charged intentional relation. I argue that to explain joint attention we need to leave the received understanding of propositions and propositional attitudes and the picture of content connected to it behind and embrace the notions of subject mode and position mode content. I also explore the relation between joint attention and communication.

How can people function appropriately and respond normatively in social contexts even if they are not aware of rules governing these contexts? John Searle has rightly criticized a popular way out of this problem by simply asserting that they follow them unconsciously. His alternative explanation is based on his notion of a preintentional, nonrepresentational background. In this paper I criticize this explanation and the underlying account of the background and suggest an alternative explanation of the normativity of elementary social practices (...) and of the background itself. I propose to think of the background as being intentional, but nonconceptual, and of the basic normativity or proto-normativity as being instituted through common sensory-motor-emotional schemata established in the joint interactions of groups. The paper concludes with some reflections on what role this level of collective intentionality and the notion of the background can play in a layered account of the social mind and the ontology of the social world. (shrink)

In this paper I propose three steps to overcome the force-content dichotomy and dispel the Frege point. First, we should ascribe content to force indicators. Through basic assertoric and directive force indicators such as intonation, word order and mood, a subject presents its position of theoretical or practical knowledge of a state of affairs as a fact, as something that is the case, or as a goal, as something to do. Force indicators do not operate on truth- or satisfaction evaluable (...) entities as on the traditional view, but complete and unify them. Second, higher-level acts such as interrogative, logical and fictional acts create higher-level unities that may suspend commitment to the assertions and directions they operate on. But they do not cancel their force, but transfer the meaning of force indicators into the new unities they create. For example, in the context of asking a theoretical or practical question, the assertoric or directive force indicator now presents the kind of knowledge the subject is seeking. Third, the Frege point conflates different varieties of force. We neither need Frege’s assertion sign, nor Hare’s neustic, nor Hanks’s cancellation sign, but only ordinary force indicators and interrogative, logical and fictional markers. Propositions are not forceless contents to which a subject commits by forceful acts, but forceful acts put forward by higher-level acts which may suspend commitment to them. (shrink)

In this paper I want to introduce and defend what I call the "subject mode account" of collective intentionality. I propose to understand collectives from joint attention dyads over small informal groups of various types to organizations, institutions and political entities such as nation states, in terms of their self-awareness. On the subject mode account, the self-consciousness of such collectives is constitutive for their being. More precisely, their self-representation as subjects of joint theoretical and practical positions towards the world – (...) rather than as objects of such positions – makes them what they are. Members of such collectives represent each other as co-subjects of such positions and thus represent the world from the point of view of the collective. (shrink)

This paper discusses Raimo Tuomela's we-mode account in his recent book "Social Ontology: Collective Intentionality and Group Agents" and develops the idea that mode should be thought of as representational. I argue that in any posture – intentional state or speech act – we do not merely represent a state of affairs as what we believe, or intend etc. – as the received view of 'propositional attitudes' has it –, but our position relative to that state of affairs and thus (...) ourselves. That is, we represent the subject through what I call "subject mode" and its position through what I call "position mode". I argue that the key to understanding collective intentionality is to understand how we represent others as co-subjects of positions rather than as their objects. This is shown on various levels of collective intentionality. On the non-conceptual level of joint attention we experience others as co-subjects who we attend with rather than to and who we are at least also disposed to act jointly with. On the conceptual level of the we-mode we represent others as co-subjects of positions of knowledge, intention, belief and shared values. Organizations and thus group agents in Tuomela's sense I propose to understand in terms of what I call "role mode", that is, in terms of the positions individuals and groups take as occupants of certain roles, for example, as committee members, or as chancellor of Germany. I try to show how this account, while very much in the spirit of Tuomela's, can avoid his fictionalism about group agents and some other problems of his account, while steering between the Scylla of excessive individualism and the Charybdis of extreme collectivism. (shrink)

Altruismus scheint im Alltagsverständnis seinen uneingeschränkt positiven Ruf als ebenso wünschenswerte wie seltene Tugend verloren zu haben und durch ein Ethos des Eigennutzens ersetzt worden zu sein. Angesichts globaler Krisen wie dem Klimawandel, großer Flüchtlingsbewegungen, Kriege und Armut ist die Bereitschaft zur Verhaltensänderung bzw. zum Verzicht zugunsten kommender Generationen oder hilfsbedürftiger Menschen weniger selbstverständlich als das Phänomen der psychologischen Reaktanz und die Weigerung, Einschränkungen der persönlichen Freiheit oder des Konsums hinzunehmen. Zeitgenössische Ethikerinnen und Ethiker müssen sich demnach mit der Frage (...) nach der Motivation für ein Handeln auseinandersetzen, das in erster Linie nicht dem eigenen Wohl, sondern dem Wohl anderer dient. In diesem Sinne beleuchtet der vorliegende Band das Thema Altruismus in seinen verschiedenen, wechselseitig aufeinander verweisenden Facetten: Wie ist das Wesen altruistischen Handelns zu bestimmen? Liegt Altruismus in der Natur des Menschen? Lässt sich Altruismus widerspruchsfrei in verschiedene Ethiktypen einordnen? Wie verstehen verschiedene philosophische Traditionen und Religionen den Altruismus? In welchem Verhältnis steht der Altruismus zum guten Leben? Und: Wie ist altruistisches Handeln motiviert? Da diese Fragen in verschiedenen Fachwissenschaften und mit unterschiedlichen Perspektivierungen gestellt werden, ist dieser Sammelband interdisziplinär konzipiert: Philosophie und Religionswissenschaft kommen ebenso zu Wort wie Verhaltensökonomie und Evolutionsbiologie. Auch anthropologische, soziologische und psychologische Zusammenhänge werden beleuchtet. Dementsprechend richten sich die hier versammelten Aufsätze an ein sehr breit gefächertes akademisches Publikum, aber auch an eine interessierte öffentliche Leserschaft außerhalb des universitären Kontexts. Mit Blick auf diese Zielgruppen führen die einzelnen Beiträge in das jeweilige Thema ein und präsentieren gleichzeitig eine eigene Forschungsposition der Autorin bzw. des Autors. -/- . (shrink)

Dissident circles during the Czechoslovak communist regime were organized in semi-private islands of resistance. They saw themselves as a parallel polis in line with Arendt’s notion of political action by pursuing “life in truth,” authentic experience, and ultimately freedom. The heroes of these circles were that society’s pariahs. In their quest for authenticity, they turned to the past to find meaning, to understand the nature of their communities and the needs for political action towards the future. As such, they sought (...) what Heidegger would label authentic public interpretations. After 1989, these heroes shaped and adapted to the constitutional design of the new polis and often experienced a transformation from pariah to inauthentic hero to at least the potential to become strong man, maintaining varying degrees of authenticity. (shrink)

The distinction between the force/mode of speech acts and intentional states and their propositional content has been a central feature of analytic philosophy since Gottlob Frege and Bertrand Russell. In this introduction we present the distinction and its motivation and review some recent challenges to it that appeal to the problem of the unity of the proposition, in order to give the reader a sense of the current state of debate to which the contributions of this volume respond.

Freiwilligkeit, personale Identität (im Sinne eines harmonisch verfassten und stabilen Selbst) und epistemische Gewissheit sind bei den meisten antiken Philosophieschulen untrennbar miteinander verbunden und garantieren im Rahmen einer als Lebenskunst verstandenen Philosophie das Glück. Im Anlehnung an Überlegungen bei Aristoteles und dem zeitgenössischen Philosophen Peter Bieri analysieren wir, wie Entscheidungen, die zum Zeitpunkt ihres Treffens als bedingt frei und selbstbestimmt wahrgenommen wurden, im Nachhinein vom Han-delnden aufgrund des damals fehlenden Wissens über die Handlungsumstände als unfrei wahrgenommen werden und zu Erfahrungen (...) der Selbstentfremdung führen können. Anknüpfend an Pamela Hieronymis Unterscheidung zwischen zwei Formen der Ausübung mentaler Freiheit zeigen wir anhand von fiktiven Fallbeispielen, wie die Protagonisten trotz epistemischer Ungewissheit zur Autorität über ihren Geist sowie zu einer funktionalen Selbstbeziehung zurückfinden können, und stellen dies in den Kontext einer zeitgenössischen Philosophie als Lebenskunst. (shrink)

Článek ukazuje pohled na utváření novověké koncepce pokroku v dílech Bernarda Le Boviera de Fontenelle. Idea pokroku byla poprvé přesně zformulována právě ve Fontenellových pracích. Podnětem pro Fontenellovy úvahy byla intelektuální debata querelle des anciens et des modernes. Tato diskuze měla rozhodnout o nadřazenosti novověku nad antikou nebo naopak. Fontenelle se debaty účastnil a závěry, k nimž došel, dovršily jeho teorii pokroku, jíž se věnoval nejen téměř ve všech pracích, ale též ve chvalořečích.

In this paper I criticize theory-biased and overly individualist approaches to understanding others and introduce the PAIR account of joint attention as a pragmatic, affectively charged intentional relation. I argue that this relation obtains in virtue of intentional contents in the minds of the co-attenders, and – against the received understanding of intentional states as propositional attitudes – that we should recognize what I call “subject mode” and “position mode” intentional content. Based on findings from developmental psychology, I propose that (...) subject mode content represents the co-attenders as co-subjects, who are like them and who are at least disposed to act jointly with them. I conclude by arguing that in joint attention we experience and understand affective, actional and perceptual relations at a non-conceptual level prior to the differentiation of mind and body. (shrink)

How can the law be characterized in a theory of collective intentionality that treats collective intentionality as essentially layered and tries to understand these layers in terms of the structure and the format of the representations involved? And can such a theory of collective intentionality open up new perspectives on the law and shed new light on traditional questions of legal philosophy? As a philosopher of collective intentionality who is new to legal philosophy, I want to begin exploring these questions (...) in this paper. I will try to characterize the law in terms of the layered account of collective intentionality that I have introduced in some earlier writings (Schmitz 2013; 2018). In the light of this account I will then discuss a traditional question in the philosophy of law: the relation between law and morality. I begin by giving a brief sketch of the layered account in the next section. Collective intentionality should be understood in terms of experiencing and representing others as co-subjects, rather than as objects, of intentional states and acts on different layers or levels. I distinguish the nonconceptual layer of the joint sensory-motor-emotional intentionality of joint attention and joint bodily action, the conceptual level of shared we-mode beliefs, intentions, obligations, values, and so on, and the institutional level characterized through role differentiation, positions taken in role-mode, e.g. as a judge or attorney, and writing and other forms of documentation. In the third section I introduce a set of parameters for representations such as their degree of richness, of context-dependence, of density and differentiation of representational role and of durability and stability, which can be used to more precisely distinguish different layers. I also put forward the hypothesis that these properties are connected and tend to cluster, and that higher levels can only function and determine conditions of satisfaction against lower level ones. In the fourth and final section I critically discuss the sharp positivistic separation of morality and the law according to which whether something is a law is completely independent of its moral merits. I argue that this only seems plausible if we take an observational stance towards the law, but not towards morality. When we treat them the same way, it rather appears that the moral attitudes of the co-subjects of a society will determine whether and to what extent they will accept its legal order. I conclude by proposing to think of the law as being itself an institutionalized form of morality. (shrink)

This essay examines the status of events of 1989 in Czechoslovakia from an Arendtian perspective, focusing on whether they qualify as a revolution or even, precisely speaking, a modern event. For Arendt, revolutions are decidedly modern in that they expand freedom to all equally, an expansion conceivable because history can be thought of as rectilinear and because new ideas can be introduced into the secular world. Leaving aside the importance of violence as a criterion, we find that 1989 in Czechoslovakia (...) does not live up to her other criteria, nor does it make sense to call it either modern or postmodern. We thus claim that it is an ‘immodern’, non-revolutionary event. In concluding, we nd that its immodernity is why it failed to be a revolution. (shrink)

A gas in a box is perhaps the most important model system studied in thermodynamics and statistical mechanics. Usually, studies focus on the gas, whereas the box merely serves as an idealized confinement. The present article focuses on the box as the central object and develops a thermodynamic theory by treating the geometric degrees of freedom of the box as the degrees of freedom of a thermodynamic system. Applying standard mathematical methods to the thermody- namics of an empty box allows (...) equations with the same structure as those of cosmology and classical and quantum mechanics to be derived. The simple model system of an empty box is shown to have interesting connections to classical mechanics, special relativity, and quantum field theory. (shrink)

A perceptual realism that is naive in a good way must be naively realistic about world and mind. But contemporary self-described naive realists often have trouble acknowledging that both the good cases of successful perception and the bad cases of illusion and hallucination involve internal experiential states with intentional contents that present the world as being a certain way. They prefer to think about experience solely in relational terms because they worry that otherwise we won’t be able to escape from (...) radical skepticism. I argue that experiential relations to objects require that their subjects be in internal experiential states. But this does not mean that these states are our epistemological starting point which can be known independently of any knowledge of the external world. We do escape the epistemological predicament of radical skepticism because the good cases are primary over the bad ones. But this is not because the good cases alone provide reasons for belief, but because we do not need a reason to think we are in a good case, but do need a reason to think we are not, and such a reason must come from a good case. So bad cases can only be thought of as deviations from good cases. And we can only understand experiences as states with contents distinct from their objects and present in good and bad cases once we understand misrepresentation, that is, bad cases, and therefore only as we ascribe knowledge of the external world to ourselves. (shrink)

The contribution deals with knowledge of what to do, and how, where, when and why to do it, as it is found in a multitude of plans, rules, procedures, maxims, and other instructions. It is argued that while this knowledge is conceptual and propositional, it is still irreducible to theoretical knowledge of what is the case and why it is the case. It is knowledge of goals, of ends and means, rather than of facts. It is knowledge-to that is irreducibly (...) practical in having world to mind direction of fit and the essential function of guiding as yet uncompleted action. While practical knowledge is fundamentally different from theoretical knowledge in terms of mind-world relations, the practical and theoretical domains are still parallel in terms of justificatory and inferential relations, they are like mirror images of one another. It is shown that if this view of practical knowledge is accepted, convincing Gettier cases for practical knowledge can be constructed. An extensive analysis of these cases demonstrates the usefulness of the notions of practical deduction, abduction, and induction. (shrink)

In diesem Aufsatz argumentiere ich, dass die Standardauffassung von Propositionen und propositionalen Einstellungen inadäquat ist, ein Artefakt der gegenwärtig herrschenden theorielastigen Auffassung von Intentionalität, Sprache und Rationalität, und skizziere eine alternative Auffassung. Im folgenden Abschnitt belege ich erst einmal die These der Theorielastigkeit anhand einiger Beispiele vor allem aus der gegenwärtigen analytischen Philosophie. Der dritte Abschnitt erklärt, wie diese Theorielastigkeit im Standardverständnis von Propositionen und propositionalen Einstellungen verkörpert ist. Im vierten Abschnitt argumentiere ich, dass dieses Standardverständnis der Proposition zwei unvereinbare (...) Rollen zuweist. Sie kann nicht sowohl einen Sachverhalt repräsentieren, der Gegenstand praktischer genauso wie theoretischer Stellungnahmen sein kann, als auch wie eine theoretische Stellungnahme Wahrheitswertträger sein. In den folgenden Abschnitten versuche ich eine partielle Diagnose, wie es zu dieser Auffassung kommen kann: gewisse Formen der Neutralisierung von Stellungnahmen durch das bloße „in den Raum stellen“ (fünfter Abschnitt), durch fiktionale Kontexte (sechster Abschnitt) und den Kontext logischer Verknüpfungen (der so genannte „Frege-Punkt“; siebter Abschnitt) werden verwechselt mit der Neutralität zwischen dem Praktischen und Theoretischen, zwischen Wollen und Wahrheit, die die Standardauffassung erfordern würde. Der achte Abschnitt skizziert in groben Umrissen ein alternatives Bild. Demnach wird eine Repräsentation eines Sachverhalts erst durch die dazu kommende theoretische oder praktische Position zu einer Stellungnahme und damit zum Träger eines Erfüllungswerts. Die Bereiche des Praktischen und des Theoretischen sind parallel strukturiert und unterschieden sich im Wesentlichen nur durch die Verschiedenheit der Passrichtungen. Grundlegende rationale Operationen wie Deduktion, Abduktion und Induktion können auf praktischen Stellungnahmen genauso ausgeführt werden wie auf theoretischen. Im neunten Abschnitt verorte ich die tieferen Wurzeln der Theorielastigkeit in dem Verlangen, das Praktische an die dem Theoretischen eigene Form der Objektivität zu assimilieren. Dieses Verlangen muss aber fruchtlos bleiben, und die dem Praktischen eigene Form der Objektivität wird so verfehlt. Der letzte Abschnitt deutet an, wie sich Werturteile in dem skizzierten Rahmen deuten lassen. (shrink)

Harry S. Broudy has studied the utility of general education through the development and testing of his Newspaper Test of the Uses of Schooling (NPT). The results of research with a new version of the NPT are reported in this essay and some options for future research are presented. The results of the study indicate that continued development and testing of the NPT will prove important. Promising new versions of the test are suggested for future research to pursue, including a (...) Hypertest version. Additional instruments and research strategies are also suggested that could be used to broaden the "search for evidence" of the uses of schooling. (shrink)

Abstract. The dissertation defends the thesis that the mind-body problem arises against the background of the elimination of the manifest physical world, and that the only satisfactory response to it is to take back that elimination and thus to dissolve the problem. Various materialist and dualist responses are shown to be inadequate. They are only different forms of ontological fundamentalism – physics fundamentalism and consciousness fundamentalism – that lead to ultimately meaningless metaphysical constructions. By contrast, on the ontologically pluralist view (...) outlined here, the fact that the entire spatiotemporal world has a physical microstructure is compatible with a naive realism with regard to both the manifest physical world and to consciousness. We only need to ascribe physical microstructures to both while identifying neither with these structures. After an introduction that identifies the elimination of the manifest physical world in modernity as the metaphysical background of the mind-body problem and describes the dilemmatic situation created by the typical reactions to it, the first chapter attempts to clarify what consciousness is. The second chapter then discusses some of the standard formulations of the so-called “puzzle” or “mystery” of consciousness. It is shown that these cannot be transformed into a genuine, answerable question. The notion that other macrophenomena can be explained much better than consciousness, perhaps even in a completely transparent way, is revealed to be an illusion, an artefact of the tacit elimination of the manifest physical world. In the third chapter, the thesis that consciousness has spatial properties is defended against various forms of skepticism. The fourth chapter begins the debate with the mind-body identity theory by discussing various positions on identity statements in the philosophy of language. This discussion leads to the conclusion that the idea of informative identity statements is meaningless. On this basis, the notion of an empirically contentful so-called “scientific identification” of consciousness phenomena with their neuronal correlates is criticized in the fifth chapter. The sixth chapter argues that it is possible to dissolve the problem of mental causation if a physiological and ultimately also a microphysical structure is ascribed to consciousness. In a concluding reflection it is explained what it means that the present suggestion amounts to a dissolution rather than a solution of the traditional mind-body problem. Zusammenfassung. In dieser Arbeit wird die These vertreten, dass das Leib-Seele- Problem vor dem Hintergrund der Elimination der manifesten physischen Welt entsteht und die einzig befriedigende Reaktion darauf nur sein kann, diese Elimination wieder rückgängig zu machen und das Problem damit aufzulösen. Materialistische und dualistische Reaktionen werden als unzulänglich erwiesen. Sie sind nur verschiedene Formen eines ontologischen Fundamentalismus – Physikfundamentalismus und Bewusstseinsfundamentalismus – der zu letztlich sinnlosen metaphysischen Konstruktionen führt. Dagegen ist nach dem hier vertretenen ontologischen Pluralismus die Tatsache, dass die gesamte raumzeitliche Welt eine physikalische Mikrostruktur hat, mit einem naiven Realismus sowohl in Bezug auf die manifeste physische Welt als auch in Bezug auf das Bewusstsein vereinbar. Wir müssen nur beiden eine physikalische Mikrostruktur zuschreiben ohne sie mit dieser zu idenfizieren. Nachdem in der Einleitung die Elimination der manifesten physischen Welt in der Neuzeit als der metaphysische Hintergrund des Leib-Seele-Problems identifiziert und die durch die typischen Reaktionen darauf entstehende dilemmatische Aus- gangssituation beschrieben worden ist, klärt das erste Kapitel, was Bewusstsein ist. Im zweiten Kapitel werden dann einige gängige Formulierungen des so genannten „Bewusstseinsrätsels“ vorgestellt. Es wird gezeigt, dass diese sich nicht in eine wirklich beantwortbare Frage transformieren lassen. Die Vorstellung, dass sich andere Makrophänomene wesentlich besser erklären lassen als das Bewusstsein, oder gar in vollständig transparenter Weise, wird als Illusion, als Artefakt der stillschweigenden Elimination der manifesten Welt erwiesen. Im dritten Kapitel wird die These, dass das Bewusstsein räumliche Eigenschaften hat, gegen verschiedene Formen der Skepsis verteidigt. Im vierten Kapitel beginnt die Auseinandersetzung mit der Identitätstheorie mit einer Diskussion sprachphilosophischer Positionen zu Identitätsaussagen, die die These begründet, dass die Vorstellung informativer Identitätsaussagen sinnlos ist. Auf dieser Grundlage wird im fünften Kapitel die Vorstellung einer empirisch gehaltvollen so genannten „wissenschaftlichen Identifikation“ von Bewusstseinsphänomenen mit ihren neuronalen Korrelaten kritisiert. Im sechsten Kapitel wird gezeigt, dass sich das Problem mentaler Verursachung auflösen lässt, wenn man Bewusstseinsphänomenen eine physiologische und letztlich auch physikalische Mikrostruktur zuschreibt. In einer Schlussbetrachtung wird erläutert, warum der Vorschlag in dieser Arbeit eine Auflösung statt einer Lösung des Leib-Seele-Problems darstellt. (shrink)

How can consciousness, how can the mind be causally efficacious in a world which seems—in some sense—to be thoroughly governed by physical causality? Mental causation has been a nagging problem in philosophy since the beginning of the modern age, when, inspired by the rise of physics, a metaphysical picture became dominant according to which the manifest macrophysical world of rocks, trees, colors, sounds etc. could be eliminated in favor of, or identified with, the microconstituents of these entities and their basic (...) physical properties, plus their effects on human or animal minds. Against the background of this ontology, the argument from causal closure, or the causal completeness of physics, exerts strong pressure to also identify consciousness with microphysical entities—or even to eliminate it in favor of the latter—the only other options apparently being either the denial of the causal closure of the physical level, epiphenomenalism about the mind, or the view that its physical effects are generally overdetermined. In this paper, however, I want to introduce what I call the “microstructure view” (MV) of the brain-consciousness relation, and I want to try to make plausible that the problem of mental causation can also be solved, or perhaps rather dissolved, on the basis of this account. On the MV, the minimal neuronal correlates of consciousness—of the global state of consciousness, or specific states of consciousness such as pain—are not identical with these states, but rather constitute their microstructure, or, as I shall also say, equivalently, compose them. (shrink)

The Frege point to the effect that e.g. the clauses of conditionals are not asserted and therefore cannot be assertions is often taken to establish a dichotomy between the content of a speech act, which is propositional and belongs to logic and semantics, and its force, which belongs to pragmatics. Recently this dichotomy has been questioned by philosophers such as Peter Hanks and Francois Recanati, who propose act-theoretic accounts of propositions, argue that we can’t account for propositional unity independently of (...) the forceful acts of speakers, and respond to the Frege point by appealing to a notion of force cancellation. I argue that the notion of force cancellation is faced with a dilemma and offer an alternative response to the Frege point, which extends the act-theoretic account to logical acts such as conditionalizing or disjoining. Such higher-level acts allow us to present forceful acts while suspending commitment to them. In connecting them, a subject rather commits to an affirmation function of such acts. In contrast, the Frege point confuses a lack of commitment to what is put forward with a lack of commitment or force in what is put forward. (shrink)

The book presents the first comprehensive survey of limits of the intentional control of action from an interdisciplinary perspective. It brings together leading scholars from philosophy, psychology, and the law to elucidate this theoretically and practically important topic from a variety of theoretical and disciplinary approaches. It provides reflections on conceptual foundations as well as a wealth of empirical data and will be a valuable resource for students and researchers alike. Among the authors: Clancy Blair, Todd S. Braver, Michael W. (...) Cole, Anika Fäsche, Maayan Davidov, Peter Gollwitzer, Kai Robin Grzyb, Tobias Heikamp, Gabriele Oettingen, Rachel McKinnon, Nachschon Meiran, Hans Christian Röhl, Michael Schmitz, John R. Searle, Gottfried Seebaß, Gisela Trommsdorff, Felix Thiede, J. Lukas Thürmer, Frank Wieber. (shrink)

Does the polis face the demos with hostility? Do citizens contest the city? Is a people in opposed separation from its political institutions? A multidisciplinary collection on people and the institutions they find themselves in and under, the essays here engage questions of the individual , communities, leadership, populism, citizenship, social media, and technology. The collection includes work by philosophers, political scientists, and political theorists using quantitative, historical, and hermeneutical methodologies to take on some of the most pressing issues of (...) our historical moment. (shrink)

Questions are not on all fours with assertions or directions, but higher-level acts that can operate on either to yield theoretical questions, as when one asks whether the door is closed, or practical questions, as when one asks whether to close it. They contain interrogative force indicators, which present positions of wondering, but also assertoric or directive force indicators which present the position of theoretical or practical knowledge the subject is striving for. Views based on the traditional force-content distinction take (...) the indicative mood for granted and therefore do not understand assertion in contrast to direction, but in contrast to questions and other higher-level acts such as logical and fictional acts. But a corresponding sign like Frege's judgement stroke can only redundantly signal the absence of a higher-level act. (shrink)

In addition to the Frege point, Frege also argued for the force-content distinction from the fact that an affirmative answer to a yes-no question constitutes an assertion. I argue that this fact more readily supports the view that questions operate on and present assertions and other forceful acts themselves. Force is neither added to propositions as on the traditional view, nor is it cancelled as has recently been proposed. Rather higher level acts such as questioning, but also e.g. conditionalizing, embed (...) assertive or directive acts that are forceful and committal, while suspending commitment to them. The Frege point confounds different varieties of force and the question whether something is merely presented for consideration with the question what is so presented. Force is representational: through assertoric and directive force indicators subjects non-conceptually present positions of theoretical or practical knowledge, while interrogative acts indicate positions of wondering which strive for such knowledge. (shrink)

In this paper I first introduce Tomasello’s notion of thought and his account of its emergence and development through differentiation, arguing that it calls into question the theory bias of the philosophical tradition on thought as well as its frequent atomism. I then raise some worries that he may be overextending the concept of thought, arguing that we should recognize an area of intentionality intermediate between action and perception on the one hand and thought on the other. After that I (...) argue that the co-operative nature of humans is reflected in the very structure of their intentionality and thought: in co-operative modes such as the mode of joint attention and action and the we-mode, they experience and represent others as co-subjects of joint relations to situations in the world rather than as mere objects. In conclusion, I briefly comment on what Tomasello refers to as one of two big open questions in the theory of collective intentionality, namely that of the irreducibility of jointness. (shrink)

Recenze: Robert Goulding. Defending Hypatia: Ramus, Savile and the Renaissance Rediscovery of Mathematical History, New York: Springer, 2010, 201 s.

This article aims to analyze the functioning of thought experiments in ethics. We will demonstrate that although many thought experiments in ethics can be reconstructed as arguments, according to the thesis defended by John Norton, its reconstructed version does not have the same epistemic force. We will argue that the reconstructed versions are not capable of bringing the same type of understanding in relation to thought experiments, which have an explanatory advantage that arguments do not have. Therefore, arguments are not (...) a sufficient condition for solving problems within ethics and also within thought experiments in this area. We will argue that emotions can be one of the non-argumentative factors that can produce negative and positive interference on thought experimenters and thought experiment, which cannot be demonstrated accurately in the reconstructed version. In this way, the reconstructed version is not able to convey an adequate understanding of emotions and other influences. Finally, we will elaborate on two thought experiments that demonstrate the need to use emotions in moral actions based on the criticism produced by Flávio Williges against traditional moral theories. These thought experiments can be reconstructed as arguments, but without giving us the same understanding that thought experiments are capable of. (shrink)

Um dos principais problemas epistemológicos que podem ser encontrados no estudo dos experimentos mentais diz respeito ao critério de escolha entre casos que produzam resultados contraditórios. Que justificação possuímos para escolher entre C e ~C? James Roberto Brown argumenta a favor de um critério de probabilidade, onde se atribui probabilidade aos dois fenômenos e o mais provável de ser verdadeiro é o que aceitamos. John Norton argumenta que experimentos mentais são argumentos, por isso eles podem ser reconstruídos como argumentos. Através (...) desse processo podemos encontrar as falhas na argumentação do experimento e decidir, através de justificação lógica, qual é a conclusão correta. A abordagem de Brown se mostra muito infrutífera por não apresentar como o cálculo de probabilidade deve funcionar, nem como é possível atribuir probabilidades a verdade dos resultados dos experimentos mentais. Por outro lado, para aceitar a resposta de Norton, necessitamos aceitar que experimentos mentais realmente façam uso de argumentos e que isso seja tudo o que podemos dizer sobre eles. Essa estruturação não permite nenhuma outra fonte epistêmica para justificar os resultados dos experimentos metais. (shrink)

The chapter describes the sharing economy in Germany as a heterogeneous dynamic, combining local trends and histories with economic forms drawing on experiences mainly from across Europe and North America. Increasingly taken into account by policymakers in the regulation of markets and the redesign of innovation governance frameworks, “sharing” as a complex nexus linking the exercise of citizenship to sustainable consumption and informational self-determination in digital societies will continue to drive and frame the creation of value chains. Of particular interest (...) are linkages between sharing economies and the traditions of cooperativism, currently experiencing a renaissance. The latter is key because it shapes the context in which sharing economy initiatives exist and expand—an opening of definitions and narrative of innovation, of value, and of collaborative agency and cooperative management. (shrink)

The terms “collaborative economy” or “sharing economy” have been commonly used in recent years to refer to a proliferation of initiatives, business models and forms of work. To observe this significant phenomenon is necessary to take into consideration a new perspective on social, economic, environmental, and political processes that can be created from a number of assets and skills, in innovative ways and at an unprecedented scale. Using of digital technologies for collaboration, communication, coordination, and value creation purposes is included (...) under the same umbrella of the collaborative economy. Market-focused digital innovation is able to disrupt existing business models and support economic activity. The situation in the area of the collaborative economy in Slovakia seems to be different from that of the Western European countries. Data from the area of sharing economy are not registered with the Statistical Office of the Slovak Republic, and there is no analysis examining its impact. We introduce a short summary of case studies examining the collaborative economy platforms in Slovakia and some issues of taxation of the collaborative economy. (shrink)

This chapter traces the genealogy of the term atmosphere in the German language, identifies historical semantic shifts, and points to its grammatical specifics. The state of research on atmospheres is briefly summarized and an overview is offered of the various definitions of the term in different disciplines. Drawing on Timothy Morton’s theory of ambient poetics, and on Hermann Schmitz’s “new phenomenology,” four key characteristics of atmospheres are discussed and elaborated: their mereological constitution, their modal structure, their intensification at affective (...) thresholds, and their affective efficacy through suggestions of movement. (shrink)

In this paper I offer critical attention to the notion of atmosphere in relation to music. By exploring the concept through the case study of the Closed Brethren worship services, I argue that atmosphere may provide analytical tools to explore the ineffable in ecclesial practices. Music, just as atmosphere, commonly occupies a realm of ineffability and undermines notions such as inside and outside, subject and object. For this reason I present music as a means of knowing the atmosphere. The first (...) part of this paper points to the limits of an understanding of atmosphere as a constellation of things, as proposed by Gernot Böhme. In contrast to this, Hermann Schmitz conceptualises atmosphere as half-thing which suggests movement. Drawing on this, I propose to methodologically approach atmospheres as movements. Consequently, in the second part of this paper I closely analyse two motions as they cohere in Closed Brethren worship services: first, becoming (Deleuze and Guattari), a movement on the level of the individual worshiper; secondly, territorialisation (Deleuze and Guattari), a movement of the atmosphere towards its solidification. Here music as atmosphere is not a system of moral signification but a generative power affording intimate processes of divine encounter, whilst producing affective denominational difference. (shrink)

Die Natur ist als Thema in der Phänomenologie von Husserl bis zu Schmitz wenig bearbeitet worden. Der Grund ist teilweise in der respektvollen oder auch kritischen Distanz vieler Phänomenologen zur Naturwissenschaft zu suchen, teils darin, dass es auf dem Feld der Selbstgegebenheit - Leib, Gefühl, zwischenmenschliche Beziehungen - zunächst die eigentlichen Entdeckungen zu machen galt. Selbst die Leibphilosophie wurde nicht als ein Teil einer Phänomenologie der Natur entwickelt. Doch ist der Leib nicht die Natur, die wir selbst sind? Im (...) vorliegenden Band unternehmen Forscher verschiedener Herkunft die gemeinsame Anstrengung, mit dem Thema Natur der Phänomenologie ein neues Forschungsfeld zu eröffnen. Dabei wird nicht nur an die phänomenologische Bewegung angeknüpft, sondern auch an aristotelische goethische Naturwissenschaft, soweit sie als phänomenologisch betrachtet werden kann. Damit wird die Absicht verfolgt, die Phänomenologie der Natur als eine alternative Erkenntnisweise im Unterschied zur herrschenden naturwissenschaftlich-technischen zu entwickeln. Nach der Entfaltung des Programms wird zunächst die goethische Naturwissenschaft als ein Paradigma von Naturphänomenologie dargestellt. Dann werden die Beiträge aus der phänomenologischen Bewegung (Husserl, Klages, Schmitz) durchmustert. Und schließlich werden Fallbeispiele gegenwärtiger phänomenologischer Erforschung der Natur vorgeführt. Dabei geht es einerseits um Beiträge von seiten goetheanischer Wissenschaft (Botanik und Wärmelehre), andererseits um Beispiele, die im Rahmen der Naturphilosophie entstanden sind (Phänomenologie von Wind und Wetter, Phänomenologie des eigenen Leibes als Natur, Phänomenologie der Stoffe). (shrink)

The conception of subjectivity developed by the German philosopher Hermann Schmitz (1927-) is especially suitable for cross-cultural investigations because its foundations lie in human experiences that are basic and universal. The paper has two aims. Firstly, to give an outline of Schmitz’s theory. Secondly, to show its usefulness (and its limits) by interpreting some Greek and Indian philosophers which, at the same time, represent certain main approaches to the problem of subjectivity.

The present paper aims at showing that the phenomenological method is a crucial methodological element of every research that is based on the interpretation of utterances or texts based on experiences, like religious studies. Following the neophenomenological school, the notion of “phenomenon” is understood in a radically relative way: “A phenomenon for a person at a given point of time is a state of affairs for which this person cannot — in spite of trying to vary the presuppositions she makes (...) as much as possible — withdraw the belief that it is a fact” (Schmitz, 2003: 1). Starting from this notion, phenomenology may fruitfully criticise two common strategies: reduction and construction. The first one tries to reduce experiences to allegedly more fundamental processes like electrical impulses in neural nets. Here the phenomenologist must object that in doing so without preceding phenomenological analysis the reductionist will lose large parts of potentially important information. As to the second strategy, constructions — in the sense of presuppositions, ready-made concepts etc. — are present in all texts that are meant to express an experience. In order to describe the underlying experience more adequately, the phenomenological researcher has to remove as many constructions as possible. In this way she does not only produce a description that is ”closer” to the experience (though she can never hope to fully grasp it), but she also paves the way for comparison and dialogue across religions and cultures. (shrink)

Die Beschäftigung mit Platon hat eine lange Geschichte, Rezeptionen seines Denkens sind so prägend für die Philosophiegeschichte geworden, dass diese verständlicherweise zuweilen als eine Sammlung von Fußnoten zu seinem Werk begriffen wurde. Das gilt besonders für einen durchgängigen metaphysischen Zug des abendländischen Denkens, ein grundsätzliches Ordnungsmodell aus der Antike, das, christlich gewendet, die Theoriebildung bis in unsere Tage fundiert. Aber mit einer Reihe anderer Gewissheiten ist auch dieser erfolgreiche Platonismus Gegenstand der Kritik geworden. Kann und soll man den metaphysischen Platon (...) retten oder muss man Platon vielmehr gegen die metaphysische Tradition neu verstehen? Muss man Platon gegen die Platonisten verteidigen, ist er der Anfang einer philosophischen Verirrung? -- Dorothea Frede, Ekkehard Martens, Arbogast Schmitt, Gernot Böhme, Hermann Schmitz, Wolfgang Detel und andere entdecken – auch durch ihre Kritik – Platon als Gesprächspartner der Gegenwart neu. (shrink)

DESENVOLVIMENTO EMBRIONÁRIO E DIFERENCIAÇÃO SEXUAL -/- E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede -/- 1.1 INTRODUÇÃO O sexo foi definido como a soma das diferenças morfológicas, fisiológicas e psicológicas que distinguem o macho da fêmea permitindo a reprodução sexual e assegurando a continuidade das espécies. Os processos de diferenciação sexual são realizados durante o desenvolvimento embrionário, onde ocorre a proliferação, diferenciação e maturação das células germinativas e primordiais, precursoras (...) de ovócitos e espermatozoides em fêmeas e machos, respectivamente. Assim, os embriões machos e fêmeas iniciam o seu desenvolvimento de forma semelhante, de modo que em ambos os sexos se estabelecem em estruturas idênticas a partir das quais se formarão os órgãos reprodutores correspondentes a cada sexo. O conhecimento da origem e do desenvolvimento do aparelho genital é indispensável para entender sua função e as alterações que produzem infertilidade ou esterilidade. 1.2 DETERMINAÇÃO DO SEXO CROMOSSÔMICO Nos mamíferos, o sexo cromossômico é determinado no momento da fertilização, quando um óvulo, que contém um cromossomo X, é fecundado por um espermatozoide portador de um cromossomo X ou um cromossomo Y. No primeiro caso, o complemento cromossômico seria XX, o que originaria uma fêmea (sexo homogamético), e no segundo daria como resultado um macho com a fórmula cromossômica XY (sexo heterogâmico). 1.3 A GÔNADA INDIFERENCIADA A primeira manifestação das gônadas se aprecia no embrião em forma de um par de eminências longitudinais chamadas cristas ou dobras gonodais, situadas em ambos os lados da linha média entre os mesonefros (rins em desenvolvimento) e do mesentério dorsal. Nos embriões dos mamíferos, as células germinativas primordiais (CGP) manifestam-se em estágios precoces do desenvolvimento, podendo ser detectadas pela primeira vez na metade da gastrulação. As CGP são células grandes, de citoplasma claro e núcleo grande e redondo, localizadas na parede do saco vitelino, perto do alantoide. Essas células possuem grande capacidade de proliferação e vão migrar desde o endoderma do intestino e o epitélio do saco vitelino, através do mesentério, até as cristas gonodais. Isso ocorre por volta do 26° dia da gestação no bovino. Sua migração realiza-se graças aos movimentos de translocação passiva e deslocamento ameboide ativo. Desconhece-se o mecanismo pelo qual estas células são dirigidas para as cristas gonodais, porém foram estudadas algumas moléculas que se expressam durante sua migração e que poderiam desempenhar um papel importante na diferenciação deste tipo celular. A fosfatase alcalina é uma enzima que tem sido usada como marcador de CGP para determinar a sua origem e migração. Num estudo recente, foi inserido um marcador fluorescente que se exprime unicamente nas células germinativas primordiais de embriões transgênicos, e utilizando este marcador e a fosfatase alcalina determinou-se a origem e o padrão de migração destas células. O primeiro sinal de diferenciação das células germinativas primordiais é a expressão de fosfatase alcalina, e esta apareceu pela primeira vez na parte mais posterior da linha primitiva. No sétimo dia de desenvolvimento no embrião do camundongo, o endoderma visceral (AF+) é substituído pelo endoderma definitivo (AF-) originado na parte anterior da linha primitiva. O fator de transcrição Oct-4 é expresso nas CGP de ambos os sexos, pelo que acredita-se estar envolvido na mantença a totipotêncialidade das células. O receptor tirosina quinase, cujo ligante é o fator de Steel, é outra das moléculas que expressam as CGP. Tem sido demonstrado que este receptor possui um papel muito importante na sobrevivência deste tipo celular. Existem outros fatores que promovem a sobrevivência e/ou proliferação de CGP in vitro. Em experiências realizadas com o fator de transformação beta I (TGFβ-I), observou-se que este tem um efeito negativo sobre a proliferação das CGP. Outra atividade que tem sido postulada a este fator é o de um agente quimioatraente que possivelmente possa direcionar a migração destas células para a gônada. a) Um formado pelas células germinativas primordiais (precursoras dos gametas masculinos ou femininos), rodeadas de células somáticas das quais posteriormente se derivarão as células de Sertoli no macho e as células da granulosa na fêmea. b) O tecido que formará o estroma da gônada: tecido conjuntivo, vasos sanguíneos e as células intersticiais com atividade esteroidogênica (células de Leydig no testículo e a teca interna do ovário). As células somáticas do primórdio gonodal originam-se do mesoderma. Inicialmente são de três tipos: mesenquimáticas, mesoteliais e endoteliais. As células mesenquimáticas e mesoteliais iniciam grande atividade proliferativa ao chegar as CGP. Observa-se então uma condensação de células de origem mesotelial e mesenquimatoso que forma um agregado compacto denominado "blastema gonodal". A partir deste primórdio embrionário, diferenciam-se dois tecidos gonodais: os cordões sexuais e o estroma. Os cordões sexuais são arranjos epiteliais que se encontram delimitados por uma folha basal, e dentro deles encontramos as CGP. Por sua vez, no estroma encontram-se células do tipo mesenquimático e vasos sanguíneos. Neste momento, as gônadas são indiferenciadas e bipotencialmente sexuais, sendo impossível diferenciar, morfologicamente, uma gônada masculina de uma feminina, mas no caso dos machos genéticos já existe uma diferenciação da gônada a nível molecular. Nesta fase já se encontram presentes as estruturas das quais se desenvolvem os dutos mesonéfricos ou de Wolff precursores do aparelho genital masculino e os dutos paramesonéfricos ou de Müller que darão origem ao aparelho reprodutor feminino. Há uma série de fatores envolvidos no desenvolvimento precoce da gônada, entre os quais o fator esteroidogênico I (SFI: Steroidogenic fator l), que é um membro da subfamília de receptores nucleares, receptores órfãos. Este fator de transcrição tem um local de ligação ao DNA composto por dois dedos-de-Zinc. O SFI foi identificado como um ativador de genes envolvidos na biossíntese de esteroides em diferentes células. O SFI está presente durante o desenvolvimento embrionário em regiões associadas com funções endócrinas como gônadas, adrenais, pituitárias e hipotálamos. Os animais homozigotos para o gene SFI defeituoso, necessitam de gônadas e adrenais e têm a função gonadotrófica alterada. Os ratos sem SFI carecem de gonadotrofos e têm um desenvolvimento anormal do núcleo ventro-medial do hipotálamo; em particular as gônadas deixam de se desenvolver entre os dias 11 a 15 e degeneram-se por apoptose. No entanto, a crista genital forma-se e é colonizada pelas células germinativas, o que indica que estas continuam a receber o sinal adequado para a sua migração. Portanto, o SFI não está envolvido no desenvolvimento precoce da gônada e do sistema urogenital, mas parece estar envolvido na manutenção do crescimento das células somáticas presentes na gônada indiferenciada. O gene associado ao tumor de Wilms (WTI: Wilm's tumor Associated) está envolvido no desenvolvimento da gônada e do rim. Durante o desenvolvimento embrionário, WTI se expressa em todo o mesoderma intermediário e posteriormente na gônada indiferenciada, bem como no rim em formação. WTI regula o sinal indutivo do mesênquima para o epitélio celômico dos mesonefros. Se este for o caso, então WTI é responsável pelo crescimento da crista genital ao dirigir a entrada do epitélio celômico. Dado que estas células darão origem às células de Sertoli, a carência de WTI pode causar o desenvolvimento de embriões XY como fêmeas simplesmente porque não se formam as células de Sertoli. Em geral, todos os genes importantes na diferenciação do mesoderma intermediário e do sistema urogenital intervêm no desenvolvimento da gônada precoce. 1.4 DIFERENCIAÇÃO GONODAL O desenvolvimento das gônadas e ductos genitais descritos até o momento, é o mesmo para ambos os sexos. Igualmente, os genes descritos, que estão envolvidos no desenvolvimento das gônadas, ductos genitais e migração das células germinativas, afetam igualmente os embriões com genótipo XX ou XY. A gônada primitiva consiste anatomicamente de uma medula (interna) e uma crosta (externa), e de acordo com o local onde ocorre a colonização das células germinativas, diferenciara em testículo ou um ovário, respectivamente. Nos mamíferos, a primeira manifestação estrutural de diferenciação sexual é detectada na gônada dos machos, onde as células germinativas estão localizadas na medula. A diferenciação do testículo inicia-se quando os cordões sexuais se separam do epitélio celômico como consequência dos arranjos produzidos por uma invasão do mesênquima e vasos sanguíneos que provoca a compactação dos cordões, agora denominados cordões testiculares. As células que rodeiam os cordões se achatam e formam as células mioides, que são responsáveis pela formação das membranas basais. As células do epitélio interno, ou seja, as células de Sertoli, têm duas funções principais: o suporte das CGP e a síntese da hormona antimulleriana, responsável pela regressão dos ductos de Müller e secretada durante o período de diferenciação sexual. As células do estroma que rodeiam os cordões testiculares diferenciam-se para formar vários tipos de células: células mioides, fibroblastos, endotélio e células de Leydig, que são as mais importantes pela sua atividade endócrina. Posteriormente, os cordões testiculares dão origem aos túbulos seminíferos, que contêm o epitélio que produzirá os espermatozoides ao chegar à puberdade. Na fêmea, durante os estágios iniciais de diferenciação gonodal, não se observam mudanças em relação à gônada indiferenciada, só pode-se observar um certo crescimento devido à proliferação de células somáticas e germinativas. As células germinativas iniciam um período de proliferação, que termina com o início da meiose. Iniciada a meiose, dá-se o processo de foliculogênese; neste momento os cordões epiteliais se fragmentam, de tal maneira que cada ovócito fica rodeado de células epiteliais cobertas por uma folha basal fina (figura 1). Para que a gônada primitiva se desenvolva em testículo é indispensável a presença do cromossoma Y, independentemente do número de cromossomas X que contenha o genoma de um indivíduo. O gene determinante do testículo encontra-se localizado no cromossoma Y, denominado sry em ratos e SRY em humanos. O gene sry se expressa durante o desenvolvimento embrionário na crista genital de embriões de camundongos. A expressão é detectável no dia 10,5, pouco depois do aparecimento das cristas genitais, atinge o seu máximo durante o dia 11,5 e mantém-se até pouco depois de ocorrerem os primeiros sinais morfológicos de diferenciação testicular no dia 12,5. Este padrão de expressão é compatível com a teoria de que sry atua induzindo a ativação dos genes (figura 2) que conduzem ao desenvolvimento testicular, sem que exista a necessidade da expressão contínua de sry para manter a diferenciação do testículo após o dia 12,5. Como mencionado anteriormente, a gônada primitiva é composta por vários tipos de células. No entanto, as células germinativas primordiais não são o local de expressão do sry, já que os embriões que necessitam de células germinativas mantêm a expressão de sry e desenvolvem o sexo gonodal normalmente. As células somáticas na gônada em desenvolvimento incluem também as células de suporte. Sabe-se que é nestas células que o sry é expresso para que se diferenciem em células de Sertoli, e a expressão transitória de sry indica que deve ativar a outros genes para a manutenção das células de Sertoli. Uma vez diferenciadas as células de Sertoli, elas se encarregarão da diferenciação do resto das células na gônada. -/- Figura 1: Representação da diferenciação dos órgãos genitais internos. Adaptado de BRONSON, 1989. Figura 2: Cascada de genes envolvidos na diferenciação sexual, adaptado de KOOPMAN, 1999. O fator sry é necessário para a diferenciação do testículo. Embora não se conheçam os genes que provavelmente regulam esse gene, estudos realizados em camundongos demonstram que este gene parece coordenar-se com certos genes autossômicos. Entre estes genes autossômicos, o sox9, que é produzido pelas células de Sertoli uma vez que são estimuladas por sry, de modo que sox9 é um dos genes relacionados estruturalmente com sry. O Sox9 funciona como um fator de transcrição, mas não se sabe se a proteína tem qualquer outra função estrutural; este gene exprime-se abundantemente nos condrócitos e está relacionado com defeitos do aparelho ósseo chamados displasia campomélica. Curiosamente, os pacientes XY com esta condição sofrem frequentemente de reversão do sexo. O Sox9 é um dos poucos genes, além do SRY, do qual as mutações demonstraram interferir com a determinação sexual masculina. No entanto, apenas 75% dos pacientes com anomalias esqueléticas de tipo displasia campomélica têm reversão sexual e não foram encontrados casos de reversão sexual devido a um defeito de Sox9 que não seja acompanhado de defeitos esqueléticos. Isso indica que o Sox9 é apenas um membro da rede de genes que são ativados para determinar a diferenciação sexual, enquanto a rota que rege a condrogênese é mais sensível a perturbações deste. O momento em que se detecta a expressão do gene Sox9 (11dpc em ratos) coincide com a máxima expressão de sry, o que poderia indicar a possibilidade de que sry regule positivamente a Sox9. De fato, na região do promotor de Sox9 há um local de união ao que potencialmente se pode unir o sry. A expressão de Sox9 durante a diferenciação sexual sugere um papel abaixo de sry na diferenciação das células de Sertoli. O cromossoma X também é importante na diferenciação gonodal. O gene DAX-I foi isolado do lócus DSS (Dosage sensitive sex reversal) do cromossoma X. DAX-I é parte da cascata de determinação sexual, mas não é necessário para a formação do testículo. DAX-I é um membro dos receptores nucleares conhecidos como receptores órfãos. Este gene demonstrou ser um poderoso repressor da transcrição de SFI e de vários genes. Os padrões de expressão de DAX-I são complementares daqueles de SFI, ambos expressos nas cristas genitais. Em resumo, dada a evidência exposta, desenvolveu-se a hipótese de que DAX-I é um antagonista de sry; esse antagonismo é dependente dos níveis relativos de DAX-I e sry e de um limiar que varia de espécie para espécie. A DAX-I foi classificada como o gene antitestículo. Na fêmea (cariótipo XX) é importante que ocorra a inativação de um dos cromossomas sexuais X para que se mantenha o equilíbrio genético ao igualar o conteúdo de DNA dos cromossomas. Esse cromossoma inativado constitui o chamado corpúsculo de Barr. No entanto, para que a meiose se realize, é necessário dos dois cromossomas X ativos nos ovócitos para assegurar a diferenciação ovárica e a fertilidade. 1.5 DIFERENCIAÇÃO DOS DUCTOS SEXUAIS O embrião possui, além das gônadas indiferenciadas, dois sistemas de ductos: os de potencialidade masculina denominam-se ductos de Wolff ou mesonéfricos, e os de potencialidade feminina se chamam ductos de Müller ou paramesonéfricos (figura 1). Se a diferenciação gonodal levou à formação de um testículo, a partir do ducto mesonéfrico ou de Wolff se desenvolverão os ductos eferentes, o epidídimo, os ductos deferentes e as vesículas seminais. As hormonas importantes no desenvolvimento do aparelho genital masculino são a testosterona, produzida pelas células de Leydig, e sua forma 5α reduzida, a 5α di-hidrotestosterona. Acredita-se que a testosterona é responsável pela virilização dos ductos de Wolff, e a di-hidrotestosterona dos órgãos genitais externos. No macho, os canais de Müller atrofiam-se devido à ação de uma hormona fetal de origem testicular denominada hormona inibidora das estruturas de Müller (HIM) ou hormona antimulleriana. Este processo começa assim que os cordões espermáticos se formam e se diferenciam as células de Sertoli. A existência de HIM foi proposta baseada em estudos realizados em bezerras freemartin, devido à existência de uma hormona responsável pela atresia dos ductos de Müller que na fêmea dá origem ao útero e aos ovidutos. Essa hormona provoca a involução do aparelho genital do bovino nas gestações gemelares nas quais os produtos de diferente sexo têm comunicação sanguínea por ter ocorrido a anastomose dos vasos de ambas as placentas (figura 3). A HIM é uma glicoproteína pertencente à subfamília de TGFβ, é expressa pelas células que darão origem às células de Sertoli e é um dos primeiros marcadores de diferenciação nestas células. A HIM é secretada na vida adulta pelas células de Sertoli no testículo e por células da granulosa no ovário. No rato a HIM é expressa-se no 12° dia em um teste padrão que segue muito de perto o aumento na expressão de sry. No macho, esta secreção de HIM continua durante a vida fetal e adulta, contudo os níveis de HIM declinam na puberdade devido a um aumento na secreção de testosterona. Vários fatores intervêm na regulação do gene de HIM, incluindo os acima descritos SFI e Sox9. O gene HIM contém segmentos de DNA que são conservados em várias espécies de vertebrados. Existe um nexo de ligação para SFI, que ativa a transcrição de HIM. A mutação no local de ligação de SFI resulta em reversão do sexo em indivíduos XY incluindo genitais femininos normais, presença de um útero formado enfatizando a importância de SFI na determinação sexual e na expressão de HIM. Embora SFI seja um bom candidato como regulador de HIM, é expresso em outras células, como as de Leydig e adrenais, que não expressam HIM. Em contrapartida, Sox9 é expresso unicamente nas células de Sertoli que são as produtoras de HIM. O gene HIM também tem um nexo de ligação para Sox9. Além disso, Sox9 pode atuar sinergicamente com SFI para promover a secreção de HIM. Ao contrário destes dois fatores de transcrição, DAX-I antagoniza a ação de Sox9 e provavelmente SFI sobre o promotor de HIM. Assim, para que as células de Sertoli secretem HIM, a transcrição de DAX-I deve diminuir. Figura 3: Representação da diferenciação dos órgãos genitais externos. Adaptado de BRONSON, 1989. Os ductos de Wolff tornam-se o sistema de ejaculação do macho. A porção mais próxima dos testículos dá origem ao epidídimo, a parte central ao ducto deferente e a porção mais distal às vesículas seminais. A próstata e a parte membranosa da uretra do macho desenvolvem-se a partir da porção pélvica do seio urogenital. A virilização e diferenciação dos ductos de Wolff dependem da produção de testosterona pelo testículo. Quanto aos órgãos genitais externos do macho, o tubérculo genital é ampliado e as dobras uretrais se fundem para formar a uretra peniana. A fusão das dobras uretrais aproxima os tubérculos genitais para formar o escroto (figura 4). Figura 4: Diferenciação do aparelho genital da fêmea e do macho. Adaptado de KOOPMAN, 1989. A diferenciação dos órgãos genitais da fêmea ocorre de forma passiva, já que a ausência de testículos e por isso da hormona inibidora dos ductos de Müller (HIM), assim como dos andrógenos virilizantes, favorece o desenvolvimento dos ductos de Müller, enquanto os de Wolff sofrem atrofia. A porção cefálica dos ductos de Müller dá origem aos ovidutos, que na sua terminação caudal se fundem com o útero. O contato dos ductos de Müller com o seio urogenital induz uma intensa proliferação celular que resulta na formação da área uterovaginal localizado entre o seio urogenital e os ductos de Müller. As células do prato uterovaginal proliferam e aumentam a distância entre as duas estruturas criando o espaço que formará a vagina quando o prato é canalizado e forma um lúmen. Em contraste com o que ocorre no macho, na fêmea a maior parte do seio urogenital se mantém exposta na superfície da abertura onde desembocam a vagina e a uretra. O tubérculo urogenital da fêmea tem um crescimento limitado e forma o clitóris. A sequência de passos da diferenciação sexual do aparelho genital é resumida na tabela 1. Tabela 1: Destino em desenvolvimento dos rudimentos sexuais dos fetos macho e fêmea dos mamíferos -/- Rudimento sexual Macho Fêmea Gônada Testículo Ovário Ductos de Müller (Paramesonéfricos) Vestígios Útero, parte da vagina, ovidutos Ductos de Wolff (Mesonéfricos) Ductos eferentes deferentes, epidídimo, vesículas seminais Vestígios Seio urogenital Uretra, próstata, glândulas bulbouretrais Parte da vagina, uretra, vestíbulo, glândulas vestibulares Tubérculo genital Pênis Clitóris Pregas vestibulares Escroto Lábios vulvares Fonte: HAFEZ, 2004. 1.6 DIFERENCIAÇÃO SEXUAL DO HIPOTÁLAMO Os processos de diferenciação sexual não se limitam apenas às células somáticas do organismo do feto, mas incluem também os centros nervosos superiores do cérebro. Assim, da mesma maneira que a gônada e os ductos sexuais se desenvolvem para o tipo feminino ou masculino, propôs-se que o cérebro pode ser "masculinizado" ou permanecer "Feminizado". A diferenciação do hipotálamo vai depender do ambiente esteroidal do neonato e ocorre na fase perinatal. Estes eventos serão de grande transcendência na vida reprodutiva do indivíduo. Tanto a fêmea como o macho nascem com a capacidade de secreção de gonadotropinas de acordo com um padrão cíclico; contudo, no macho, a exposição do hipotálamo à ação dos andrógenos testiculares durante os primeiros dias da vida extrauterina provoca a masculinização, com o qual o hipotálamo do macho é programado para que a secreção de gonadotropinas se realize a um ritmo relativamente constante por parte da hipófise (secreção tônica). Na fêmea, tanto a secreção tônica como a cíclica se conservam. No entanto, observou-se que a injeção de testosterona ou o transplante de testículo na rata fêmea durante os primeiros dias de vida, suprime a sua futura atividade estral (secreção cíclica). Por outro lado, se os ovários forem transplantados para o rato macho normal castrado na idade adulta, o animal não desenvolve qualquer atividade cíclica, mas se os machos transplantados forem castrados ao nascer, o ovário é capaz de efetuar mudanças cíclicas e ovulações. Isto foi demonstrado em roedores, mas não em animais domésticos ou na espécie humana. Portanto, o padrão de secreção de gonadotropinas, seja cíclico ou tônico, não depende da hipófise, mas do hipotálamo e sua correta diferenciação. 1.7 CONCLUSÕES A maioria dos conhecimentos no campo da biologia do desenvolvimento e, muito especificamente, dos processos de diferenciação sexual têm sido originados de estudos relacionados com desordens congênitas, que na sua maioria devem-se a defeitos de genes específicos. A análise detalhada destas desordens permitiu entender alguns mecanismos endócrinos, moleculares e genéticos envolvidos na diferenciação sexual. A identificação do gene sry como determinante do testículo foi uma contribuição crucial e abriu as portas à compreensão dos mecanismos moleculares e celulares relacionados com o desenvolvimento do testículo. Se este gene não estiver presente, é criado um programa genético alternativo para levar a cabo a diferenciação gonodal para o ovário. Finalmente, devemos ter presente que é necessária uma correlação entre mudanças morfológicas e expressão de genes durante o desenvolvimento para entender os mecanismos relacionados com a diferenciação. -/- Apoio -/- Realização -/- REFERÊNCIAS BIBLIOGRÁFICAS ANDERSON, Robert et al. The onset of germ cell migration in the mouse embryo. Mechanisms of development, v. 91, n. 1-2, p. 61-68, 2000. AUSTIN, Colin Russell; SHORT, R. V. Reproduction in Mammals: Volume 1, Germ Cells and Fertilization. Londres: Cambridge University Press, 1972. BRONSON, Franklin H. Mammalian reproductive biology. Chicago: University of Chicago Press, 1989. BUEHR, Mia. The primordial germ cells of mammals: some current perspectives. Experimental cell research, v. 232, n. 2, p. 194-207, 1997. BYSKOV, Anne G. Differentiation of mammalian embryonic gonad. Physiological reviews, v. 66, n. 1, p. 71-117, 1986. CAPEL, Blanche et al. Migration of mesonephric cells into the mammalian gonad depends on Sry. Mechanisms of development, v. 84, n. 1-2, p. 127-131, 1999. CAPEL, Blanche. The battle of the sexes. Mechanisms of development, v. 92, n. 1, p. 89-103, 2000. DERIVAUX, Jules; BARNABÉ, Renato Campanarut. Reprodução dos animais domésticos. Zaragoza: Acribia, 1980. DOMENICE, Sorahia et al. Aspectos moleculares da determinação e diferenciação sexual. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 46, n. 4, p. 433-443, 2002. DONAHOE, Patricia K. et al. Mullerian inhibiting substance activity in bovine fetal, newborn and prepubertal testes. Biology of reproduction, v. 16, n. 2, p. 238-243, 1977. HAFEZ, Elsayed Saad Eldin; HAFEZ, B. Reprodução animal. São Paulo: Manole, 2004. HANLEY, Neil A. et al. Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Molecular and cellular endocrinology, v. 163, n. 1-2, p. 27-32, 2000. HIORT, Olaf; PAUL-MARTIN, H. The molecular basis of male sexual differentiation. European journal of endocrinology, v. 142, n. 2, p. 101-110, 2000. HOLY, Lubos; MARTÍNEZ JÚSTIZ, G. Colab. Biología de la reproducción bovina. Havana: Revolucionária, 1975. JOSSO, Nathalie et al. The role of anti-Müllerian hormone in gonadal development. Molecular and cellular endocrinology, v. 145, n. 1-2, p. 3-7, 1998. JOST, Alfred et al. Studies on sex differentiation in mammals. In: Proceedings of the 1972 Laurentian Hormone Conference. Londres: Academic Press, 1973. p. 1-41. KNOBIL, Ernst. Knobil and Neill's physiology of reproduction. EUA: Gulf Professional Publishing, 2006. KOFMAN ALFARO, S.; MERCHANT LARIOS, H.; PEREZ PALACIOS, G. Diferenciacion sexual. I. Bases biologicas del dimorfismo sexual. Rev. invest. clín, p. 349-59, 1982. KOOPMAN, Peter. Sry and Sox9: mammalian testis-determining genes. Cellular and Molecular Life Sciences CMLS, v. 55, n. 6-7, p. 839-856, 1999. MCDONALD, L. E. Veterinary endocrinology. Lea & Febiger, Philadelphia, Pa, 1969. MEIZEL, S.; JOHNSON, M. H. Development in mammals. MH Johnson, Ed, v. 3, p. 1-64, 1978. MELLO, Maricilda Palandi de; ASSUMPÇÃO, Juliana de G.; HACKEL, Christine. Genes envolvidos na determinação e diferenciação do sexo. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 49, n. 1, p. 14-25, 2005. -/- REFERÊNCIAS BIBLIOGRÁFICAS MERCHANT-LARIOS, H. Ovarian differentiation. The Vertebrate Ovary, p. 47-81, 1978. MIES FILHO, Antonio. Reprodução dos animais. Porto Alegre: Sulina, 1987. NEF, Serge; PARADA, Luis F. Hormones in male sexual development. Genes & Development, v. 14, n. 24, p. 3075-3086, 2000. PARKER, Keith L.; SCHEDL, Andreas; SCHIMMER, Bernard P. Gene interactions in gonadal development. Annual review of physiology, v. 61, n. 1, p. 417-433, 1999. SWAIN, Amanda; LOVELL-BADGE, Robin. Mammalian sex determination: a molecular drama. Genes & development, v. 13, n. 7, p. 755-767, 1999. WILHELM, Dagmar; PALMER, Stephen; KOOPMAN, Peter. Sex determination and gonadal development in mammals. Physiological reviews, v. 87, n. 1, p. 1-28, 2007. WILSON, Jean D.; GRIFFIN, James E.; GEORGE, Fredrick W. Sexual differentiation: early hormone synthesis and action. Biology of reproduction, v. 22, n. 1, p. 9-17, 1980. -/- Emanuel Isaque Cordeiro da Silva Belo Jardim, 07 de Maio de 2020. (shrink)

Indem dieser Band sich auf das Verhältnis von Naturerkennen und Natursein konzentriert, thematisiert er einen wesentlichen Ausschnitt aus dem weiten Spektrum von Böhmes philosophischer Arbeit. Um die Naturthematik möglichst breit zu entfalten und für Querverbindungen offenzuhalten, ist der vorliegende Band in drei Abschnitte gegliedert. Im ersten Abschnitt stehen Charakter und Reichweite der wissenschaftlichen Erkenntnis von Natur im Mittelpunkt. Der zweite Teil des Bandes stellt alternative Perspektiven auf Natur vor. Im dritten Teil schließlich stehen der Mensch und sein Verhältnis zu sich (...) selbst im Mittelpunkt der Untersuchungen. Inhaltsverzeichnis Krohn, Wolfgang: Wissenschaftsentwicklung zwischen Dezentrierung und Dekonstruktion. Stehr, Nico: Von den Grenzen der Macht wissenschaftlicher Erkenntnis. Schäfer, Wolf: Zweifel am Ende des Baconschen Zeitalters. Kamper, Dietmar: Wissen ist Ohnmacht. Macht ist Unwissen. Gamm, der Technik. Janich, Peter: Zeit und Natur. Kimmerle, Heinz: »Es ist Zeit, daß es Zeit wird«. Wie kann Zeit Zeit werden? Schiemann, Gregor: Natur auf dem Rückzug. Zur Relevanz der aristotelischen Unterscheidung von Natur und Technik. Hauskeller, Michael: Ist Schönheit eine Atmosphäre?. Zur Bestimmung des landschaftlich Schönen. Schmitz, Hermann: Situationen und Atmosphären. Zur Ästhetik und Onthologie bei Gernot Böhme. Rehmann-Sutter, Christoph: Über Relationalität. Was ist das »Ökologische« in der Naturästhetik? Meyer-Abich, Klaus Michael: Erinnerung an die natürliche Mitwelt. Andreas-Griesebach, Manon: Idee plus Erfahrung. Goethes Begründung eines neuen Typs von Naturwissenschaft. Engelhardt, Dietrich von: Madame de Stael über Naturphilosophie, Naturwissenschaft und Medizin in De l'Allemagne. Deneke, Michael: Schramm, Engelbert: »Soziale Naturwissenschaft«. Zwischen Sozialwissenschaften und Naturwissenschaften. Böhme, Hartmut: Enthüllen und Verhüllen des Körpers. Biblische, mythische und künstlerische Deutungen des Nackten. Lippe, Rudolf zur: Eine Logik des gestischen Wissens. Müller, Rudolf Wolfgang: Gernot Böhme - Anima naturaliter japonica. Hoffmann, Gisbert: Das menschliche Sein als mediales. Martens, Ekkehard: »Natürlich« denken?. Heideggers Pseudosokratismus als Irrationalismus. Fleischer, Helmut: Naturalität ohne Naturalismus. Zum lebensweltlichen Fundus jeder höheren Erkenntnis-Artistik. Gerhard: Technik als Medium. Grundlinien einer Philosophie. (shrink)

There is fast-growing awareness of the role atmospheres play in architecture. Of equal interest to contemporary architectural practice as it is to aesthetic theory, this 'atmospheric turn' owes much to the work of the German philosopher Gernot Böhme. Atmospheric Architectures: The Aesthetics of Felt Spaces brings together Böhme's most seminal writings on the subject, through chapters selected from his classic books and articles, many of which have hitherto only been available in German. This is the only translated version authorised by (...) Böhme himself, and is the first coherent collection deploying a consistent terminology. It is a work which will provide rich references and a theoretical framework for ongoing discussions about atmospheres and their relations to architectural and urban spaces. Combining philosophy with architecture, design, landscape design, scenography, music, art criticism, and visual arts, the essays together provide a key to the concepts that motivate the work of some of the best contemporary architects, artists, and theorists: from Peter Zumthor, Herzog & de Meuron and Juhani Pallasmaa to Olafur Eliasson and James Turrell. With a foreword by Professor Mark Dorrian and an afterword by Professor David Leatherbarrow,, the volume also includes a general introduction to the topic, including coverage of it history, development, areas of application and conceptual apparatus. (shrink)

This chapter argues that it is possible to identify, in the coming to be of knowledge, the three elements that Aristotle says are involved in any kind of coming to be whatsoever (viz., matter, form, and the generated composite object). Specifically, it is argued that in this schema the passive intellect (pathetikos nous) corresponds to the matter, the active intellect (poetikos nous) corresponds to the form, and the composite object corresponds to the mind as actually knowing.

The paper follows the thesis, that the perception of real or virtual media shares the anthropological state of "Ausdruckswahrnehmung" or perception of expression (Ernst Cassirer). This kind of perception does not represent a distant, neutral point of view, but one that is guided by feelings or "vitality affects" (Daniel N. Stern). The prerequisites, however, for triggering these feelings/"vitality affects" are not recognizable objects or motifs, but rather their sensually evaluable “abstract representations” or their formal logical structures. In contrast to aesthetic (...) feelings, however, they affect not only our feelings of lust or unlust or our knowledge (formal aesthetics) but also our actions (semiotics). So, when I extend aesthetic experiences to semiotic effects, I will talk about vitality semiotics. This new concept is of consequence, because the thesis of the responsibility of the producer is based on these effects. This is to be carried out by analyzing and presenting the approach of the Bauhaus master Josef Albers. (shrink)