Results for 'Genome formatting'

953 found
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  1. Genome Informatics: The Role of DNA in Cellular Computations.James A. Shapiro - 2006 - Biological Theory 1 (3):288-301.
    Cells are cognitive entities possessing great computational power. DNA serves as a multivalent information storage medium for these computations at various time scales. Information is stored in sequences, epigenetic modifications, and rapidly changing nucleoprotein complexes. Because DNA must operate through complexes formed with other molecules in the cell, genome functions are inherently interactive and involve two-way communication with various cellular compartments. Both coding sequences and repetitive sequences contribute to the hierarchical systemic organization of the genome. By virtue of (...)
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  2. Genomics and identity: the bioinformatisation of human life. [REVIEW]Hub Zwart - 2009 - Medicine, Health Care and Philosophy 12 (2):125-136.
    The genomics “revolution” is spreading. Originating in the molecular life sciences, it initially affected a number of biomedical research fields such as cancer genomics and clinical genetics. Now, however, a new “wave” of genomic bioinformation is transforming a widening array of disciplines, including those that address the social, historical and cultural dimensions of human life. Increasingly, bioinformation is affecting “human sciences” such as psychiatry, psychology, brain research, behavioural research (“behavioural genomics”), but also anthropology and archaeology (“bioarchaeology”). Thus, bioinformatics is having (...)
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  3. Ethical Discourse on Epigenetics and Genome Editing: The Risk of (Epi-) genetic Determinism and Scientifically Controversial Basic Assumptions.Karla Alex & Eva C. Winkler - 2023 - In Michael Welker, Eva Winkler & John Witte Jr (eds.), The Impact of Health Care on Character Formation, Ethical Education, and the Communication of Values in Late Modern Pluralistic Societies. Leipzig: Evangelische Verlagsanstalt & Wipf & Stock Publishers. pp. 77-99.
    Excerpt: 1. Introduction This chapter provides insight into the diverse ethical debates on genetics and epigenetics. Much controversy surrounds debates about intervening into the germline genome of human embryos, with catchwords such as genome editing, designer baby, and CRISPR/Cas. The idea that it is possible to design a child according to one’s personal preferences is, however, a quite distorted view of what is actually possible with new gene technologies and gene therapies. These are much more limited than the (...)
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  4. Age of Genetics and the age of biotechnology on the way to editing of, human genome.Valentin Teodorovich Cheshko (ed.) - 2016 - Moscow Russia: Kurs-INFRA-M.
    The book discusses some of the stages in the development of genetics, biotechnology in terms of basic strategy of humanity towards the formation of a modern agrarian civilization. Agricultural civilization is seen as part of the biosphere and primary user of its energy flows. Consistently a steps of creation of management tools for live objects to increasing the number of food security of mankind are outlines. The elements of the biosphere degradation started in the results of human activities, and the (...)
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  5. Coding the Self: The Infopolitics and Biopolitics of Genetic Sciences.Colin Koopman - 2020 - Hastings Center Report 50 (S1):6-14.
    This article compares three models for conceptualizing the political and ethical challenges of contemporary genetics, genomics, and postgenomics. The three analytical approaches are referred to as the state-politics model, the biopolitical model, and the infopolitical model. Each of these models is valuable for different purposes. But comparing these models in terms of their influence in contemporary discussions, the first is by far the dominant approach, the second is gaining in importance, and the third is almost entirely neglected. The widespread neglect (...)
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  6. The Plant Ontology facilitates comparisons of plant development stages across species.Ramona Lynn Walls, Laurel Cooper, Justin Lee Elser, Maria Alejandra Gandolfo, Christopher J. Mungall, Barry Smith, Dennis William Stevenson & Pankaj Jaiswal - 2019 - Frontiers in Plant Science 10.
    The Plant Ontology (PO) is a community resource consisting of standardized terms, definitions, and logical relations describing plant structures and development stages, augmented by a large database of annotations from genomic and phenomic studies. This paper describes the structure of the ontology and the design principles we used in constructing PO terms for plant development stages. It also provides details of the methodology and rationale behind our revision and expansion of the PO to cover development stages for all plants, particularly (...)
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  7. EVOLUTIONARY RISK OF HIGH HUME TECHNOLOGIES. Article 1. STABLE ADAPTIVE STRATEGY OF HOMO SAPIENS.V. T. Cheshko, L. V. Ivanitskaya & V. I. Glazko - 2014 - Integrative Anthropology (2):4-14.
    Stable adaptive strategy of Homo sapiens (SASH) is a result of the integration in the three-module fractal adaptations based on three independent processes of generation, replication, and the implementation of adaptations — genetic, socio-cultural and symbolic ones. The evolutionary landscape SASH is a topos of several evolutionary multi-dimensional vectors: 1) extraversional projective-activity behavioral intention (adaptive inversion 1), 2) mimesis (socio-cultural inheritance), 3) social (Machiavellian) intelligence, 4) the extension of inter-individual communication beyond their own social groups and their own species in (...)
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  8. Genomics and self-knowledge. Implications for societal research and debate.Hub Zwart - 2007 - New Genetics and Society 26 (2):181-202.
    When the Human Genome Project (HGP) was launched, our genome was presented as our ‘blueprint’, a metaphor reflecting a genetic deterministic epistemology. Eventually, however, the HGP undermined rather than strengthened the understanding of genomes as blueprints and of genes as ultimate causal units. A symbolical turning point was the discovery that the human genome only contains 22,500 genes. Initially, this was seen as a narcissistic offence. Gradually, however, it strengthened the shift from traditional genetics and biotechnology (i.e., (...)
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  9. Reproductive genome editing interventions are therapeutic, sometimes.César Palacios-González - 2021 - Bioethics 35 (6):557-562.
    In this paper I argue that some human reproductive genome editing interventions can be therapeutic in nature, and thus that it is false that all such interventions just create healthy individuals. I do this by showing that the conditions established by a therapy definition are met by certain reproductive genome editing interventions. I then defend this position against two objections: (a) reproductive genome editing interventions do not attain one of the two conditions for something to be a (...)
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  10. Genomics and the Ark: An Ecocentric Perspective on Human History.Hub Zwart & Bart Penders - 2011 - Perspectives in Biology and Medicine 54 (2):217-231.
    In 1990 the Human Genome Project (HGP) was launched as an important historical marker, a pivotal contribution to the time-old quest for human self-knowledge. However, when in 2001 two major publications heralded its completion, it seemed difficult to make out how the desire for self-knowledge had really been furthered by this endeavor (IHGSC 2001; Venter et al. 2001). In various ways mankind seems to stand out from other organisms as a unique type of living entity, developing a critical perspective (...)
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  11. Genomics and Public Involvement: Giving Justifications Their Due.Gabriele Badano - 2012 - Studies in Ethics, Law, and Technology 6 (1).
    The involvement of the public in the governance of genomics has become a topic of growing interest among scholars, practitioners and policy-makers. The implementation of public involvement programmes may be quite expensive, and the design and evaluation of public participation is a matter of controversy. Thus, this paper examines the justifications for public participation in the governance of genomic research to help understand whether public involvement is worthwhile and to provide a guide to the design of public participation. I identify (...)
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  12. Genomic Stress Responses Drive Lymphocyte Evolvability: An Ancient and Ubiquitous Mechanism.Bartlomiej Swiatczak - 2020 - Bioessays 42 (10):2000032.
    Somatic diversification of antigen receptor genes depends on the activity of enzymes whose homologs participate in a mutagenic DNA repair in unicellular species. Indeed, by engaging error-prone polymerases, gap filling molecules and altered mismatch repair pathways, lymphocytes utilize conserved components of genomic stress response systems, which can already be found in bacteria and archaea. These ancient systems of mutagenesis and repair act to increase phenotypic diversity of microbial cell populations and operate to enhance their ability to produce fit variants during (...)
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  13. The Genome as the Biological Unconscious – and the Unconscious as the Psychic 'Genome': A Psychoanalytical Rereading of Molecular Genetics.Hub Zwart - 2013 - Cosmos and History 9 (2):198-222.
    1900 was a remarkable year for science. Several ground-breaking events took place, in physics, biology and psychology. Planck introduced the quantum concept, the work of Mendel was rediscovered, and Sigmund Freud published The Interpretation of Dreams . These events heralded the emergence of completely new areas of inquiry, all of which greatly affected the intellectual landscape of the 20 th century, namely quantum physics, genetics and psychoanalysis. What do these developments have in common? Can we discern a family likeness, a (...)
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  14. Genome editing: slipping down toward Eugenics?Davide Battisti - 2019 - Medicina Historica 3 (3):206-218.
    In this paper, I will present the empirical version of the slippery slope argument (SSA) in the field of genome editing. According to the SSA, if we adopt germline manipulation of embryos we will eventually end up performing or allowing something morally reprehensible, such as new coercive eugenics. I will investigate the actual possibility of sliding towards eugenics: thus, I will examine enhancement and eugenics both in the classical and liberal versions, through the lens of SSA. In the first (...)
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  15. The Formats of Cognitive Representation: A Computational Account.Dimitri Coelho Mollo & Alfredo Vernazzani - 2023 - Philosophy of Science (3):682-701.
    Cognitive representations are typically analysed in terms of content, vehicle and format. While current work on formats appeals to intuitions about external representations, such as words and maps, in this paper we develop a computational view of formats that does not rely on intuitions. In our view, formats are individuated by the computational profiles of vehicles, i.e., the set of constraints that fix the computational transformations vehicles can undergo. The resulting picture is strongly pluralistic, it makes space for a variety (...)
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  16. Military Genomic Testing: Proportionality, Expected Benefits, and the Connection between Genotypes and Phenotypes.Charles H. Pence - 2015 - Journal of Law and the Biosciences 2 (1):85-91.
    Mehlman and Li offer a framework for approaching the bioethical issues raised by the military use of genomics that is compellingly grounded in both the contemporary civilian and military ethics of medical research, arguing that military commanders must be bound by the two principles of paternal- ism and proportionality. I agree fully. But I argue here that this is a much higher bar than we may fully realize. Just as the principle of proportionality relies upon a thorough assessment of harms (...)
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  17. Are Synthetic Genomes Parts of a Genetic Lineage?Gunnar Babcock - 2021 - British Journal for the Philosophy of Science 72 (4):995-1011.
    Biologists are nearing the creation of the first fully synthetic eukaryotic genome. Does this mean that we still soon be able to create genomes that are parts of an existing genetic lineage? If so, it might be possible to bring back extinct species. But do genomes that are synthetically assembled, no matter how similar they are to native genomes, really belong to the genetic lineage on which they were modelled? This article will argue that they are situated within the (...)
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  18. Understanding the Human Genome Project: a biographical approach.Hub Zwart - 2008 - New Genetics and Society 27 (4):353 – 376.
    This article analyzes a number of recently published autobiographies by leading participants in the Human Genome Project (HGP), in order to determine to what extent they may further our understanding of the history, scientific significance and societal impact of this major research endeavor. Notably, I will focus on three publications that fall under this heading, namely The common thread by John Sulston (2002/2003), The language of God (2006) by Francis Collins and A life decoded by Craig Venter (2007).1 What (...)
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  19. When Should Genome Researchers Disclose Misattributed Pahentage?Amulya Mandava, Joseph Millum & Benjamin E. Berkman - 2015 - Hastings Center Report 45 (4):28-36.
    Research studies increasingly use genomic sequencing to draw inferences based on comparisons between the genetic data of a set of purportedly related individuals. As use of this method progresses, it will become much more common to discover that the assumed biological relationships between the individuals are mistaken. Consequently, researchers will have to grapple with decisions about whether to return incidental findings of misattributed parentage on a much larger scale than ever before. In this paper we provide an extended argument for (...)
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  20. On decoding and rewriting genomes: a psychoanalytical reading of a scientific revolution.Hub Zwart - 2012 - Medicine, Health Care and Philosophy 15 (3):337-346.
    In various documents the view emerges that contemporary biotechnosciences are currently experiencing a scientific revolution: a massive increase of pace, scale and scope. A significant part of the research endeavours involved in this scientific upheaval is devoted to understanding and, if possible, ameliorating humankind: from our genomes up to our bodies and brains. New developments in contemporary technosciences, such as synthetic biology and other genomics and “post-genomics” fields, tend to blur the distinctions between prevention, therapy and enhancement. An important dimension (...)
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  21. Genomes, gender and the psychodynamics of a scientific crisis: A psychoanalytic reading of Michael Crichton’s genomics novels.Hub Zwart - 2015 - New Genetics and Society 34 (1):1-24.
    Michael Crichton (1942–2008) was a prolific writer of “science novels”, portraying the psychodynamics and sociodynamics of genomics and other NBIC (Nanotechnology, Biotechnology, Information technology and Cognitive science) fields, fostering critical reflection on their societal dimensions. Science novels may serve as “literary experiments”, as windows into the (future) impacts of current research. Although on the surface level Crichton’s books may be seen as entertaining bestsellers, an in-depth reading allows them to emerge as exploratory exercises, usable as course material for science students. (...)
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  22. Ethical issues in genomics research on neurodevelopmental disorders: a critical interpretive review.Signe Mezinska, L. Gallagher, M. Verbrugge & E. M. Bunnik - 2021 - Human Genomics 16 (15).
    Background Genomic research on neurodevelopmental disorders (NDDs), particularly involving minors, combines and amplifies existing research ethics issues for biomedical research. We performed a review of the literature on the ethical issues associated with genomic research involving children affected by NDDs as an aid to researchers to better anticipate and address ethical concerns. Results Qualitative thematic analysis of the included articles revealed themes in three main areas: research design and ethics review, inclusion of research participants, and communication of research results. Ethical (...)
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  23. Introduction: Genomics and Philosophy of Race.Rasmus Grønfeldt Winther, Roberta L. Millstein & Rasmus Nielsen - 2015 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 52:1-4.
    This year’s topic is “Genomics and Philosophy of Race.” Different researchers might work on distinct subsets of the six thematic clusters below, which are neither mutually exclusive nor collectively exhaustive: (1) Concepts of ‘Race’; (2) Mathematical Modeling of Human History and Population Structure; (3) Data and Technologies of Human Genomics; (4) Biological Reality of Race; (5) Racialized Selves in a Global Context; (6) Pragmatic Consequences of ‘Race Talk’ among Biologists.
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  24. Natural Genome Editing from a Biocommunicative Perspective.Guenther Witzany - 2011 - Biosemiotics 4 (3):349-368.
    Natural genome editing from a biocommunicative perspective is the competent agent-driven generation and integration of meaningful nucleotide sequences into pre-existing genomic content arrangements, and the ability to (re-)combine and (re-)regulate them according to context-dependent (i.e. adaptational) purposes of the host organism. Natural genome editing integrates both natural editing of genetic code and epigenetic marking that determines genetic reading patterns. As agents that edit genetic code and epigenetically mark genomic structures, viral and subviral agents have been suggested because they (...)
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  25. The human genome as public: Justifications and implications.Michelle J. Bayefsky - 2016 - Bioethics 31 (3):209-219.
    Since the human genome was decoded, great emphasis has been placed on the unique, personal nature of the genome, along with the benefits that personalized medicine can bring to individuals and the importance of safeguarding genetic privacy. As a result, an equally important aspect of the human genome – its common nature – has been underappreciated and underrepresented in the ethics literature and policy dialogue surrounding genetics and genomics. This article will argue that, just as the personal (...)
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  26. Exploratory concept formation and tool development in neuroscience.Philipp Haueis - 2023 - Philosophy of Science 90 (2):354 - 375.
    Developing tools is a crucial aspect of experimental practice, yet most discussions of scientific change traditionally emphasize theoretical over technological change. To elaborate on the role of tools in scientific change, I offer an account that shows how scientists use tools in exploratory experiments to form novel concepts. I apply this account to two cases in neuroscience and show how tool development and concept formation are often intertwined in episodes of tool-driven change. I support this view by proposing common normative (...)
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  27. Reasons to Genome Edit and Metaphysical Essentialism about Human Identity.Tomasz Żuradzki & Vilius Dranseika - 2022 - American Journal of Bioethics 22 (9):34-36.
    In this commentary paper, we are taking one step further in questioning the central assumptions in the bioethical debates about reproductive technologies. We argue that the very distinction between “person affecting” and “identity affecting” interventions is based on a questionable form of material-origin essentialism. Questioning of this form of essentialist approach to human identity allows treating genome editing and genetic selection as more similar than they are taken to be in the standard approaches. It would also challenge the idea (...)
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  28. Affecting future individuals: Why and when germline genome editing entails a greater moral obligation towards progeny.Davide Battisti - 2021 - Bioethics 35 (5):1-9.
    Assisted reproductive technologies have greatly increased our control over reproductive choices, leading some bioethicists to argue that we face unprecedented moral obligations towards progeny. Several models attempting to balance the principle of procreative autonomy with these obligations have been proposed. The least demanding is the minimal threshold model (MTM), according to which every reproductive choice is permissible, except creating children whose lives will not be worth living. Hence, as long as the future child is likely to have a life worth (...)
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  29. Genopower: On Genomics, Disability, and Impairment.Joel Michael Reynolds - 2021 - Foucault Studies 31.
    Since the completion of the human genome project in 2003, genomic sequencing, analysis, and interpretation have become staples of research in medicine and the life sciences more generally. While much ink has been spilled concerning genomics’ precipitous rise, there is little agreement among scholars concerning its meaning, both in general and with respect to our current moment. Some claim genomics is neither new, nor noteworthy; others claim it is a novel and worrisome instrument of newgenics. Contrary to the approaches (...)
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  30. Re-examining the Gene in Personalized Genomics.Jordan Bartol - 2013 - Science & Education 22 (10):2529-2546.
    Personalized genomics companies (PG; also called ‘direct-to-consumer genetics’) are businesses marketing genetic testing to consumers over the Internet. While much has been written about these new businesses, little attention has been given to their roles in science communication. This paper provides an analysis of the gene concept presented to customers and the relation between the information given and the science behind PG. Two quite different gene concepts are present in company rhetoric, but only one features in the science. To explain (...)
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  31.  55
    Anticipatory gaps challenge the public governance of heritable human genome editing.Jon Rueda, Seppe Segers, Jeroen Hopster, Karolina Kudlek, Belén Liedo, Samuela Marchiori & John Danaher - 2024 - Journal of Medical Ethics.
    Considering public moral attitudes is a hallmark of the anticipatory governance of emerging biotechnologies, such as heritable human genome editing. However, such anticipatory governance often overlooks that future morality is open to change and that future generations may perform different moral assessments on the very biotechnologies we are trying to govern in the present. In this article, we identify an ’anticipatory gap’ that has not been sufficiently addressed in the discussion on the public governance of heritable genome editing, (...)
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  32. Queering the genome: ethical challenges of epigenome editing in same-sex reproduction.Adrian Villalba - forthcoming - Journal of Medical Ethics 26.
    In this article, I explore the ethical dimensions of same-sex reproduction achieved through epigenome editing—an innovative and transformative technique. For the first time, I analyse the potential normativity of this disruptive approach for reproductive purposes, focusing on its implications for lesbian couples seeking genetically related offspring. Epigenome editing offers a compelling solution to the complex ethical challenges posed by traditional gene editing, as it sidesteps genome modifications and potential long-term genetic consequences. The focus of this article is to systematically (...)
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  33. On Mentioning Belief-Formation Methods in the Sensitivity Subjunctives.Bin Zhao - forthcoming - Ergo: An Open Access Journal of Philosophy.
    According to the sensitivity account of knowledge, S knows that p only if S’s belief in p is sensitive in the sense that S would not believe that p if p were false. The sensitivity condition is usually relativized to belief-formation methods to avoid putative counterexamples. A remaining issue for the account is where methods should be mentioned in the sensitivity subjunctives. In this paper, I argue that if methods are mentioned in the antecedent, then the account is too strong (...)
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  34. Holistic biology: Back on stage? Comments on post-genomics in historical perspective.Alfred Gierer - 2002 - Philosophia Naturalis 39 (1):25-44.
    A strong motivation for the human genome project was to relate biological features to the structure and function of small sets of genes, and ideally to individual genes. However, it is now increasingly realized that many problems require a "systems" approach emphasizing the interplay of large numbers of genes, and the involvement of complex networks of gene regulation. This implies a new emphasis on integrative, systems theoretical approaches. It may be called 'holistic' if the term is used without irrational (...)
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  35. Gibt es einen therapeutischen Imperativ zum genome editing in der menschlichen Keimbahn? [Is there a therapeutic imperative for editing the human germline genome? / Existe-t-il un impératif thérapeutique à l'édition du génome dans la lignée germinale humaine].Karla Alex & Christoph Rehmann-Sutter - 2022 - URPP Human Reproduction Reloaded | H2R (University of Zurich), Working Paper Series, 05/2022. Zurich and Geneva: Seismo 1 (5):1-21.
    Abstract: This working paper focuses on the question whether there is a therapeutic imperative that, in specific situations, would oblige us to perform genome editing at the germline level in the context of assisted reproduction. The answer to this central question is discussed primarily with reference to specific scenarios where preimplantation genetic diagnosis (PGD) does not represent an acceptable alternative to germline genome editing based on either medical, or ethical, or – from the perspective of the potential parents (...)
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  36. Genomic Obsolescence: What Constitutes an Ontological Threat to Human Nature?Michal Klincewicz & Lily Frank - 2019 - American Journal of Bioethics 19 (7):39-40.
    Volume 19, Issue 7, July 2019, Page 39-40.
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  37. Editorial: Genome Invading RNA Networks.L. P. Villarreal & Guenther Witzany - 2018 - Frontiers in Microbiology 9:1-3.
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  38. The Planteome database: an integrated resource for reference ontologies, plant genomics and phenomics.Laurel Cooper, Austin Meier, Marie-Angélique Laporte, Justin L. Elser, Chris Mungall, Brandon T. Sinn, Dario Cavaliere, Seth Carbon, Nathan A. Dunn, Barry Smith, Botong Qu, Justin Preece, Eugene Zhang, Sinisa Todorovic, Georgios Gkoutos, John H. Doonan, Dennis W. Stevenson, Elizabeth Arnaud & Pankaj Jaiswal - 2018 - Nucleic Acids Research 46 (D1):D1168–D1180.
    The Planteome project provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus of plant genomics, phenomics and genetics data. The reference ontologies include the Plant Ontology, Plant Trait Ontology, and the Plant Experimental Conditions Ontology developed by the Planteome project, along with the Gene Ontology, Chemical Entities of Biological Interest, Phenotype and Attribute Ontology, and others. The project also provides (...)
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  39. Formation of global regulatory system for human resources development.S. Sardak - 2016 - In International Scientific Practical Conference «Modern Transformation of Economics and Management in the Era of Globalization». pp. 21-22.
    Focused on evolutionary and continuous human development the global, the regulatory system should be formed in the conceptual (the constant research for the detection, identification and evaluation of global imperatives) and application (development and implementation of activities and coordination tools of influence to ensure the existence of human civilization in a secure politically, economically, socially and environmentally balanced world) planes. On the author's calculations of its formation in functionally complete, holistic view is expected by 2030 due to historically conditioned transformations (...)
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  40. In the Beginning was the Genome: Genomics and the Bi-textuality of Human Existence.H. A. E. Zwart - 2018 - The New Bioethics 24 (1):26-43.
    This paper addresses the cultural impact of genomics and the Human Genome Project on human self-understanding. Notably, it addresses the claim made by Francis Collins that the genome is the language of God and the claim made by Max Delbrück that Aristotle must be credited with having predicted DNA as the soul that organises bio-matter. From a continental philosophical perspective I will argue that human existence results from a dialectical interaction between two types of texts: the language of (...)
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  41. La formation comme vecteur d’innovation des pratique pédagogiques liées aux TIC. (Cas des enseignants (es) du secondaire qualifiant de l’AREF Fès-Meknès).Mohammed Mourchid - 2023 - In الصديق الصادقي العماري, Seddik Sadiki Amari, سعاد اليوسفي & و آخرون (eds.), النظام التربوي المغربي في أفق تجديد الممارسات المهنية. maroc المغرب .Errachidia الرشيدية: Editions Revue Brochures Educatives منشورات مجلة كراسات تربوية، (سلسلة ''كتب جماعية'' رقم 01). pp. 313-337.
    Résumé : Cette contribution a pour objectif de mettre en exergue la nature de la formation dont bénéficient les enseignants du secondaire qualifiant et sa relation avec les pratiques pédagogiques qui en découlent. Elle se base sur une enquête empirique menée auprès d’un échantillon représentatif de 160 enseignants (es) appartenant à l’AREF Fès -Meknès. L’enjeu principal est, à la fois, d’identifier et d’analyser le contenu dispensé lors des formations professionnelles liées à l’usage des technologies de l’information et de la communication (...)
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  42. The Dispositional Genome: Primus Inter Pares.Christopher J. Austin - 2015 - Biology and Philosophy 30 (2):227-246.
    According to the proponents of Developmental Systems Theory and the Causal Parity Thesis, the privileging of the genome as “first among equals” with respect to the development of phenotypic traits is more a reflection of our own heuristic prejudice than of ontology - the underlying causal structures responsible for that specified development no more single out the genome as primary than they do other broadly “environmental” factors. Parting with the methodology of the popular responses to the Thesis, this (...)
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  43. The Formation of the Self. Nietzsche and Complexity.Paul Cilliers, Tanya de Villiers & Vasti Roodt - 2002 - South African Journal of Philosophy 21 (1):1-17.
    The purpose of this article is to examine the relationship between the formation of the self and the worldly horizon within which this self achieves its meaning. Our inquiry takes place from two perspectives: the first derived from the Nietzschean analysis of how one becomes what one is; the other from current developments in complexity theory. This two-angled approach opens up different, yet related dimensions of a non-essentialist understanding of the self that is none the less neither arbitrary nor deterministic. (...)
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  44. Health for Whom? Bioethics and the Challenge of Justice for Genomic Medicine.Joel Michael Reynolds - 2020 - Hastings Center Report 50 (S1):2-5.
    The guiding premise from which this special report begins is the conviction and hope that justice is at the normative heart of medicine and that it is the perpetual task of bioethics to bring concerns of justice to bear on medical practice. On such an account, justice is medicine's lifeblood, that by which it contributes to life as opposed to diminishing it. It is in this larger, historical, intersectional, critical, and ethically minded context that we must approach pressing questions facing (...)
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  45. Post-genomic musings. [REVIEW]Massimo Pigliucci - 2007 - Science 317:1172-1173.
    Everyone in biology keeps predicting that the next few years will bring answers to some of the major open questions in evolutionary biology, but there seems to be disagreement on what, exactly, those questions are. Enthusiasts of the various “-omics” (genomics, proteomics, transcriptomics, metabolomics, and even phenomics) believe, as Michael Lynch puts it in the final chapter of The Origins of Genome Architecture, that “we can be confident of two things: the basic theoretical machinery for understanding the evolutionary process (...)
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  46. Conceptual Formation in Global Thinking: Desk-bounds, Globetrotters, and Pathfinders. Editor’s Introduction.Corrado Fumagalli - 2019 - Philosophy and Public Issues - Filosofia E Questioni Pubbliche 9 (3):3-12.
    If a theory addressing problems that are global in scope aims to be convincing outside its own tradition, it should be robust-enough to deal with the simple observation that, around the world, there are multiple systems of norms, rules and institutionalized normative orders.
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  47. Habit-Formation: What's in a Perspective?William Hornett - 2022 - In Jeremy Dunham & Komarine Romdenh-Romluc (eds.), Habit and the History of Philosophy. New York, NY: Rewriting the History of Philosophy.
    I argue that Merleau-Ponty is right to claim that some shift in an agent's perspective on the world is partly constitutive of their forming a habit, but that he is wrong about what this shift is because he wrongly conflates habit and skill. I defend an alternative: the perspectiival shift constitutive of habit-formation is that habitual courses of action come to be and seem familiar.
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  48. The Formation of the Historical World in the Human Sciences (review).Eric Sean Nelson - 2004 - Journal of the History of Philosophy 42 (1):113-115.
    In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 42.1 (2004) 113-115 [Access article in PDF] Wilhelm Dilthey. The Formation of the Historical World in the Human Sciences. Edited with an Introduction by Rudolf A. Makkreel and Frithjof Rodi. Princeton: Princeton University Press, 2002. Pp xiii + 399. Cloth $55.00. The first complete English translation of Wilhelm Dilthey's (1833-1911) most important mature work—a seminal work for hermeneutics, phenomenology, critical theory, and the (...)
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  49. (1 other version)Corruption, corporate character-formation and "value-strategy".Aleksandar Fatic - 2013 - Filozofija I Društvo 24 (1):60-80.
    While most discussions of corruption focus on administration, institutions, the law and public policy, little attention in the debate about societal reform is paid to the “internalities” of anti-corruption efforts, specifically to character-formation and issues of personal and corporate integrity. While the word “integrity” is frequently mentioned as the goal to be achieved through institutional reforms, even in criminal prosecutions, the specifically philosophical aspects of character-formation and the development of corporate and individual virtues in a rational and systematic way tend (...)
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  50. The Plant Ontology as a Tool for Comparative Plant Anatomy and Genomic Analyses.Laurel Cooper, Ramona Walls, Justin Elser, Maria A. Gandolfo, Dennis W. Stevenson, Barry Smith & Others - 2013 - Plant and Cell Physiology 54 (2):1-23..
    The Plant Ontology (PO; http://www.plantontology.org/) is a publicly-available, collaborative effort to develop and maintain a controlled, structured vocabulary (“ontology”) of terms to describe plant anatomy, morphology and the stages of plant development. The goals of the PO are to link (annotate) gene expression and phenotype data to plant structures and stages of plant development, using the data model adopted by the Gene Ontology. From its original design covering only rice, maize and Arabidopsis, the scope of the PO has been expanded (...)
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