Results for 'Malcolm Cone'

130 found
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  1. The Rationality of Fundamentalist Belief.Finlay Malcolm - 2021 - Journal of Social Philosophy 54 (1):94-113.
    Religious fundamentalism remains a significant force in global politics and religion. Despite a range of problems arising from fundamentalism, the beliefs fundamentalists hold can seem quite reasonable. This paper considers whether, in fact, fundamentalist beliefs are rational by drawing on recent ideas in contemporary epistemology. The paper presents a general theory of fundamentalist beliefs in terms of their propositional content and the high credence levels attributed to them. It then explores the way these beliefs are both acquired and retained by (...)
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    4. H atom n level Bohr radii correlate with pi via a hyperbolic spiral.Malcolm Macleod - manuscript
    The electron is found at discrete energy levels within the atom, transition between these levels is considered to involve a `jump' rather than via a continuous motion. If we simulate the transition in the H atom as a series of individual steps, with each step the frequency of the electron, we can map a semi-continuous transition (from n=1 to n=2 requires about 1887860 steps, transition period a function of the photon wavelength). Plotting the electron from n=1 to ionization traces a (...)
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  3. Kumārila Bhaṭṭa and Pārthasārathi Miśra on First- and Higher-Order Knowing.Malcolm Keating - 2022 - Philosophy East and West 72 (2):396-414.
    According to the seventh-century C.E. philosopher Kumārila Bhat.t.a, epistemic agents are warranted in taking their world-presenting experiences as veridical, if they lack defeaters. For him, these experiences are defeasibly sources of knowledge without the agent reflecting on their content or investigating their causal origins. This position is known as svatah prāmāṇya in Sanskrit (henceforth the SP principle). -/- As explicated by the eleventh-century commentator, Pārthasārathi Misŕa, this position entails that epistemic agents know things without simultaneously knowing that they know them, (...)
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  4. Extreme beliefs and Echo chambers.Finlay Malcolm & Christopher Ranalli - forthcoming - In Rik Peels & John Horgan (eds.), Mapping the Terrain of Extreme Belief and Behavior. Oxford University Press.
    Are extreme beliefs constitutive of echo chambers, or only typically caused by them? Or are many echo chambers unproblematic, amplifying relatively benign beliefs? This paper details the conceptual relations between echo chambers and extreme beliefs, showing how different conceptual choice-points in how we understand both echo chambers and extreme beliefs affects how we should evaluate, study, and engage with echo chambering groups. We also explore how our theories of extreme beliefs and echo chambers shape social scientific research and contribute in (...)
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  5. Epistocracy and Public Interests.Finlay Malcolm - 2021 - Res Publica 28 (1):173-192.
    Epistocratic systems of government have received renewed attention, and considerable opposition, in recent political philosophy. Although they vary significantly in form, epistocracies generally reject universal suffrage. But can they maintain the advantages of universal suffrage despite rejecting it? This paper develops an argument for a significant instrumental advantage of universal suffrage: that governments must take into account the interests of all of those enfranchised in their policy decisions or else risk losing power. This is called ‘the Interests Argument’. One problem (...)
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  6. Can Fictionalists Have Faith?Finlay Malcolm - 2018 - Religious Studies 54 (2):215-232.
    According to non-doxastic theories of propositional faith, belief that p is not necessary for faith that p. Rather, propositional faith merely requires a ‘positive cognitive attitude’. This broad condition, however, can be satisfied by several pragmatic approaches to a domain, including fictionalism. This paper shows precisely how fictionalists can have faith given non-doxastic theory, and explains why this is problematic. It then explores one means of separating the two theories, in virtue of the fact that the truth of the propositions (...)
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  7. Testimony, Faith and Humility.Finlay Malcolm - 2021 - Religious Studies 57 (3):466-483.
    It is sometimes claimed that faith is a virtue. To what extent faith is a virtue depends on what faith is. One construal of faith, which has been popular in both recent and historical work on faith, is that faith is a matter of taking oneself to have been spoken to by God and of trusting this purported divine testimony. In this paper, I argue that when faith is understood in this way, for faith to be virtuous then it must (...)
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  8. Measuring morality in videogames research.Malcolm Ryan, Paul Formosa, Stephanie Howarth & Dan Staines - 2020 - Ethics and Information Technology 22 (1):55-68.
    There has been a recent surge of research interest in videogames of moral engagement for entertainment, advocacy and education. We have seen a wealth of analysis and several theoretical models proposed, but experimental evaluation has been scarce. One of the difficulties lies in the measurement of moral engagement. How do we meaningfully measure whether players are engaging with and affected by the moral choices in the games they play? In this paper, we survey the various standard psychometric instruments from the (...)
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  9. Focus, Sensitivity, Judgement, Action: Four Lenses for Designing Morally Engaging Games.Malcolm Ryan, Dan Staines & Paul Formosa - 2017 - Transactions of the Digital Games Research Association 2 (3):143-173.
    Historically the focus of moral decision-making in games has been narrow, mostly confined to challenges of moral judgement (deciding right and wrong). In this paper, we look to moral psychology to get a broader view of the skills involved in ethical behaviour and how these skills can be employed in games. Following the Four Component Model of Rest and colleagues, we identify four “lenses” – perspectives for considering moral gameplay in terms of focus, sensitivity, judgement and action – and describe (...)
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  10. The Pragma-Dialectics of Dispassionate Discourse: Early Nyāya Argumentation Theory.Malcolm Keating - 2022 - Religions 10 (12).
    Analytic philosophers have, since the pioneering work of B.K. Matilal, emphasized the contributions of Nyāya philosophers to what contemporary philosophy considers epistemology. More recently, scholarly work demonstrates the relevance of their ideas to argumentation theory, an interdisciplinary area of study drawing on epistemology as well as logic, rhetoric, and linguistics. This paper shows how early Nyāya theorizing about argumentation, from Vātsyāyana to Jayanta Bhaṭṭa, can fruitfully be juxtaposed with the pragma-dialectic approach to argumentation pioneered by Frans van Eemeren. I illustrate (...)
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  11. Four Lenses for Designing Morally Engaging Games.Malcolm Ryan, Dan Staines & Paul Formosa - 2016 - Proceedings of 1st International Joint Conference of DiGRA and FDG.
    Historically the focus of moral decision-making in games has been narrow, mostly confined to challenges of moral judgement (deciding right and wrong). In this paper, we look to moral psychology to get a broader view of the skills involved in ethical behaviour and how they may be employed in games. Following the Four Component Model of Rest and colleagues, we identify four “lenses” – perspectives for considering moral gameplay in terms of focus, sensitivity, judgement and action – and describe the (...)
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  12. Pramāṇa.Malcolm Keating - 2021 - In Stewart Goetz & Charles Taliaferro (eds.), The Encyclopedia of Philosophy of Religion. Hoboken, NJ: Wiley-Blackwell.
    In Indian philosophy, a pramāṇa is an epistemic instrument or doxastic practice that results in a veridical cognition (in an event of knowing). For just about all Indian thinkers, perception (pratyakṣa) and inference (anumāna) are the foundational pramāṇas, although they debated energetically over how to characterize the content of the resultant cognitions and how to explain the basis for the authority of these pramāṇas. Debate also includes the relationship of knowledge to religious liberation, the role of scripture in knowing, and (...)
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  13. How to insult and compliment a testifier.Finlay Malcolm - 2018 - Episteme 15 (1):50-64.
    Do we insult, offend or slight a speaker when we refuse her testimony? Do we compliment, commend or extol a speaker when we accept her testimony? I argue that the answer to both of these questions is “yes”, but only in some instances, since these respective insults and compliments track the reasons a hearer has for rejecting or accepting testimony. When disbelieving a speaker, a hearer may insult her because she judges the speaker to be either incompetent as a knower (...)
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  14. Ideology and Philosophy in Aristotle's Theory of Slavery.Malcolm Schofield - 1990 - In Günther Patzig (ed.), Aristoteles "Politik": Akten des XI. Symposium Aristotelicum, Friedrichshafen/Bodensee, 25.8.-3.9.1987. Göttingen: Vandenhoeck und Ruprecht. pp. 1-27.
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  15. The Institutionalist Reaction to Keynesian Economics.Malcolm Rutherford & C. Tyler DesRoches - 2008 - Journal of the History of Economic Thought 1 (30):29-48.
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  16. Playing Around With Morality: Introducing the Special Issue on “Morality Play”.Malcolm Ryan, Paul Formosa & Rowan Tulloch - 2019 - Games and Culture 14 (4):299–305.
    This special issue of Games and Culture focuses on the intersection between video games and ethics. This introduction briefly sets out the key research questions in the research field and identifies trends in the articles included in this special issue.
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  17. Democratic Legitimacy and the Competence Obligation.Finlay Malcolm - 2021 - Moral Philosophy and Politics 8 (1):109-130.
    What obligations are there on voters? This paper argues that voters should make their electoral decision competently, and does so by developing on a recent proposal for democratic legitimacy. It then explores three problems arising from this ‘competency obligation’. First, how should voters be competent? I propose three conditions required for voter competence. Second, how competent should voters be? I argue that the competency required tracks the significance of the consequences of the vote. Third, if the electorate are unlikely to (...)
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  18. Silencing and Freedom of Speech in UK Higher Education.Finlay Malcolm - 2021 - British Educational Research Journal 47 (3):520-538.
    Freedom of speech in universities is currently an issue of widespread concern and debate. Recent empirical findings in the UK shed some light on whether speech is unduly restricted in the university, but it suffers from two limitations. First, the results appear contradictory. Some studies show that the issue of free speech is overblown by media reportage, whilst others track serious concerns about free speech arising from certain university policies. Second, the findings exclude important issues concerning restrictions to speech on (...)
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  19. Justifications, Powers, and Authority.Malcolm Thorburn - 2008 - Yale Law Journal 117:1070.
    Criminal law theory made a significant advance roughly thirty years ago when George Fletcher popularized the important conceptual distinction between justifications and excuses. In the intervening years, however, very little progress has been made in exploring the structure and function of justification defenses. The reason for this failure, I suggest, is a widely shared misconception about their place within the criminal law’s institutional structure. Contrary to what is generally believed, it is not up to trial courts to decide ex post (...)
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  20. Comments on “Moral Complicity in Induced Pluripotent Stem Cell Research”.Byrnes W. Malcolm & J. Furton Edward - 2009 - Kennedy Institute of Ethics Journal 19 (2):202-205.
    In lieu of an abstract, here is a brief excerpt of the content:Comments on “Moral Complicity in Induced Pluripotent Stem Cell Research”W. Malcolm Byrnes, Ph.D. and Edward J. FurtonIn his article titled “Moral Complicity in Induced Pluripotent Stem Cell Research,” Mark T. Brown (2009) unfortunately mischaracterizes my ethical analysis of the use of induced pluripotent stem (iPS) cells for replacement therapies, or treatments (Byrnes 2008). In my paper, which Brown cites, I argue that, just as it is ethically acceptable (...)
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  21. Reinventing the Nightwatchman State?Malcolm Thorburn - 2010 - University of Toronto Law Journal 60:425-443.
    This article raises a principled objection to the privatization of certain core police services. Whereas most of the literature critical of privatizing security services has focused on the negative consequences of doing so (corruption, waste, etc.), the argument here focuses squarely on the standing of private parties to perform police services. According to an important strain of liberal political theory, certain tasks are assigned to the state not because it is deemed to be more efficient at delivering those services but (...)
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  22. Making moral machines: why we need artificial moral agents.Paul Formosa & Malcolm Ryan - forthcoming - AI and Society.
    As robots and Artificial Intelligences become more enmeshed in rich social contexts, it seems inevitable that we will have to make them into moral machines equipped with moral skills. Apart from the technical difficulties of how we could achieve this goal, we can also ask the ethical question of whether we should seek to create such Artificial Moral Agents (AMAs). Recently, several papers have argued that we have strong reasons not to develop AMAs. In response, we develop a comprehensive analysis (...)
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  23. Mathematical electron model and the SI unit 2017 Special Adjustment.Malcolm J. Macleod - manuscript
    Following the 26th General Conference on Weights and Measures are fixed the numerical values of the 4 physical constants ($h, c, e, k_B$). This is premised on the independence of these constants. This article discusses a model of a mathematical electron from which can be defined the Planck units as geometrical objects (mass M=1, time T=2$\pi$ ...). In this model these objects are interrelated via this electron geometry such that once we have assigned values to 2 Planck units then we (...)
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  24. Religious fictionalism.Michael Scott & Finlay Malcolm - 2018 - Philosophy Compass 13 (3):1-11.
    Religious fictionalism is the theory that it is morally and intellectually legitimate to affirm religious sentences and to engage in public and private religious practices, without believing the content of religious claims. This article discusses the main features of fictionalism, contrasts hermeneutic, and revolutionary kinds of fictionalism and explores possible historical and recent examples of religious fictionalism. Such examples are found in recent theories of faith, pragmatic approaches to religion, and mystical traditions in religious theology.
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  25. The Moral and Evidential Requirements of Faith.Finlay Malcolm - 2020 - European Journal for Philosophy of Religion 12 (1):117-142.
    What is the relationship between faith and evidence? It is often claimed that faith requires going beyond evidence. In this paper, I reject this claim by showing how the moral demands to have faith warrant a person in maintaining faith in the face of counter-evidence, and by showing how the moral demands to have faith, and the moral constraints of evidentialism, are in clear tension with going beyond evidence. In arguing for these views, I develop a taxonomy of different ways (...)
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  26. Policing and Public Office.Malcolm Thorburn - 2020 - University of Toronto Law Journal 70:248-266.
    In this paper, I argue that policing can be defended as consistent with the equality of all before the law – but not by denying that policing occupies a special place in our legal order that is dangerously close to certain ancien régime privileges. In order to defend the special privileges of policing, it is essential to show that they are something quite different from the ancien régime privileges that they in some respects resemble. The crucial conceptual tool for making (...)
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  27. Papers, Please and the systemic approach to engaging ethical expertise in videogames.Formosa Paul, Ryan Malcolm & Staines Dan - 2016 - Ethics and Information Technology 18 (3):211-225.
    Papers, Please, by Lucas Pope (2013), explores the story of a customs inspector in the fictional political regime of Arstotzka. In this paper we explore the stories, systems and moral themes of Papers, Please in order to illustrate the systemic approach to designing videogames for moral engagement. Next, drawing on the Four Component model of ethical expertise from moral psychology, we contrast this systemic approach with the more common scripted approach. We conclude by demonstrating the different strengths and weaknesses that (...)
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  28. (1 other version)Morality meters and their impacts on moral choices in videogames: a qualitative study.Paul Formosa, Malcolm Ryan, Stephanie Howarth, Jane Messer & Mitchell McEwan - 2022 - Games and Culture 1 (17):89-121.
    Morality meters are a commonly used mechanic in many ethically notable video games. However, there have been several theoretical critiques of such meters, including that people can find them alienating, they can instrumentalise morality, and they reduce morality to a binary of good and evil with no room for complexity. While there has been much theoretical discussion of these issues, there has been far less empirical investigation. We address this gap through a qualitative study that involved participants playing a custom-built (...)
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  29. (1 other version)Programming Planck units from a virtual electron; a Simulation Hypothesis (summary).Malcolm Macleod - 2018 - Eur. Phys. J. Plus 133:278.
    The Simulation Hypothesis proposes that all of reality, including the earth and the universe, is in fact an artificial simulation, analogous to a computer simulation, and as such our reality is an illusion. In this essay I describe a method for programming mass, length, time and charge (MLTA) as geometrical objects derived from the formula for a virtual electron; $f_e = 4\pi^2r^3$ ($r = 2^6 3 \pi^2 \alpha \Omega^5$) where the fine structure constant $\alpha$ = 137.03599... and $\Omega$ = 2.00713494... (...)
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  30. 3. Simulating gravity via Planck scale n-body particle-particle orbital pairs.Malcolm J. Macleod - manuscript
    An orbital simulation program is described that uses a geometrical approach to modeling gravitational and atomic orbits at the Planck scale. Orbiting objects A, B, C... are sub-divided into points, each point representing 1 unit of Planck mass, for example, a 1kg satellite would divide into 1kg/Planck mass = 45940509 points. Each point in object A then forms a rotating orbital pair with every corresponding point in objects B, C... resulting in a universe-wide, n-body network of rotating point-to-point orbital pairs. (...)
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  31. Programming relativity and gravity via a discrete pixel space in Planck level Simulation Hypothesis models.Malcolm J. Macleod - manuscript
    Outlined here is a simulation hypothesis approach that uses an expanding (the simulation clock-rate measured in units of Planck time) 4-axis hyper-sphere and mathematical particles that oscillate between an electric wave-state and a mass (unit of Planck mass per unit of Planck time) point-state. Particles are assigned a spin axis which determines the direction in which they are pulled by this (hyper-sphere pilot wave) expansion, thus all particles travel at, and only at, the velocity of expansion (the origin of $c$), (...)
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  32. 2. Programming relativity as the mathematics of perspective in a Planck unit Simulation Hypothesis.Malcolm Macleod - manuscript
    The Simulation Hypothesis proposes that all of reality is in fact an artificial simulation, analogous to a computer simulation. Outlined here is a method for programming relativistic mass, space and time at the Planck level as applicable for use in Planck Universe-as-a-Simulation Hypothesis. For the virtual universe the model uses a 4-axis hyper-sphere that expands in incremental steps (the simulation clock-rate). Virtual particles that oscillate between an electric wave-state and a mass point-state are mapped within this hyper-sphere, the oscillation driven (...)
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  33. Testimonial Insult: A Moral Reason for Belief?Finlay Malcolm - 2018 - Logos and Episteme (1):27-48.
    When you don’t believe a speaker’s testimony for reasons that call into question the speaker’s credibility, it seems that this is an insult against the speaker. There also appears to be moral reasons that count in favour of refraining from insulting someone. When taken together, these two plausible claims entail that we have a moral reason to refrain from insulting speakers with our lack of belief, and hence, sometimes, a moral reason to believe the testimony of speakers. Reasons for belief (...)
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  34. The Cow is to be Tied Up: Sort-Shifting in Classical Indian Philosophy.Keating Malcolm - 2013 - History of Philosophy Quarterly 30 (4):311-332.
    This paper undertakes textual exegesis and rational reconstruction of Mukula Bhaṭṭa’s Abhidhā-vṛttta-mātṛkā, or “The Fundamentals of the Communicative Function.” The treatise was written to refute Ānandavardhana’s claim, made in the Dhvanyāloka, that there is a third “power” of words, vyañjanā (suggestion), beyond the two already accepted by traditional Indian philosophy: abhidhā (denotation) and lakṣaṇā(indication).1 I argue that the explanation of lakṣaṇā as presented in his text contains internal tensions, although it may still be a compelling response to Ānandavardhana.
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  35. Christopher G. Framarin's Desire and Motivation in Indian Philosophy, Routledge Hindu Studies. [REVIEW]Malcolm Keating - 2013 - Journal of the American Oriental Society 133 (1):160-62.
    Desire and Motivation in Indian Philosophy. By Christopher G. Framarin. Routledge Hindu Studies Series. London: Routledge, 2009. Pp. xv + 196. $170 ; $44.95.
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  36. Review of ShashiPrabha Kumar, Categories, Creation and Cognition in Vaiśeṣika Philosophy. [REVIEW]Malcolm Keating - 2020 - Journal of Comparative Literature and Aesthetics 43:139-141.
    As a guide to source material, the book will be useful to readers already somewhat familiar with Vaiśeṣika, and as a reference guide, the book’s lists of categories (padārthas) and other related concepts will also be handy for the same. However, the book is less satisfactory for readers wishing for a general introduction to the study of Vaiśeṣika, given its organization, coupled with its heavy use of untranslated Sanskrit and assumption that readers are already familiar with Indian philosophy. Philosophically speaking, (...)
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  37. Why human "altered nuclear transfer" is unethical: a holistic systems view.W. Malcolm Byrnes - 2005 - The National Catholic Bioethics Quarterly 5 (2):271-279.
    A remarkable event occurred at the December 3, 2004, meeting of the U. S. President’s Council on Bioethics. Council member William Hurlbut, a physician and Consulting Professor in the Program in Human Biology at Stanford University, formally unveiled a proposal that he claimed would solve the ethical problems surrounding the extraction of stem cells from human embryos. The proposal would involve the creation of genetically defective embryos that “never rise to the level of integrated organismal existence essential to be designated (...)
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  38. A Radical Pluralist Philosophy of Religion, Mikel Burley [Review]. [REVIEW]Finlay Malcolm - forthcoming - Religious Studies.
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  39. Evidence Thresholds and the Partiality of Relational Faith.Finlay Malcolm - 2021 - Australasian Philosophical Review 5 (1):86-91.
    ABSTRACT This commentary shows how Dormandy’s ‘Partiality Norm of Belief for Faith’ can be made compatible with ‘Evidentialism about Faith’. Dormandy takes partiality to involve disrespect toward evidence—where evidence we are partial toward is given undue weight. I propose an alternative where partiality is to require more or less evidence for believing a proposition given the benefits or harms of holding the belief. Rather than disrespecting evidence, this partiality is simply to have variable ‘evidence thresholds’ that are partly set by (...)
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  40. Cultivating Intellectual Humility in Political Philosophy Seminars.Finlay Malcolm - 2019 - Blended Learning in Practice.
    The cultivation of intellectual character is an important goal within university education. This article focusses on cultivating intellectual humility. It first explores an account of intellectual humility from recent literature on the intellectual virtues. Then, it considers one recent pedagogical approach – Making Thinking Visible – as a means of teaching intellectual virtue. It assesses one particular technique for cultivating intellectual humility arising from this pedagogical literature, and applies it to the teaching of political philosophy. Finally, there is a discussion (...)
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  41. The Flawed Scientific Basis of the Altered Nuclear Transfer-Oocyte Assisted Reprogramming (ANT-OAR) Proposal.W. Malcolm Byrnes - 2007 - Stem Cell Reviews and Reports 1 (3):60-65.
    First put forth in June 2005, the altered nuclear transfer-oocyte assisted reprogramming (ANT-OAR) proposal has been promoted as an ethically-acceptable alternative to the embryo-destructive methods now used to obtain embryonic stem cells. According to its proponents, the goal of ANT-OAR is to use the cloning process to create a pluripotent stem cell. This would be achieved through overexpression of the transcription factor Nanog (or a hypothetical substitute) both in the enucleated egg cell and in the somatic cell prior to transfer (...)
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  42. Climate Justice, Hurricane Katrina, and African American Environmentalism.W. Malcolm Byrnes - 2014 - Journal of African American Studies 3 (18):305-314.
    The images of human suffering from New Orleans in the aftermath of Hurricane Katrina remain seared in our nation's collective memory. More than 8 years on, the city and its African-American population still have not recovered fully. This reality highlights an important truth: the disturbances that accompany climate change will first and foremost affect minority communities, many of whom are economically disadvantaged. This paper: (1) describes how Hurricane Katrina, an example of the type of natural disaster that will become more (...)
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  43. Partial Trajectory: The Story of the Altered Nuclear Transfer-Oocyte Assisted Reprogramming (ANT-OAR) Proposal.W. Malcolm Byrnes - 2007 - Linacre Quarterly 1 (74):50-59.
    This essay aims to tell the story of the “altered nuclear transfer-oocyte assisted reprogramming,” or ANT-OAR, proposal—from its conception by Professor William Hurlbut of the President’s Council on Bioethics—to its adoption and promotion by a group of conservative, mostly Catholic philosophers, theologians and scientists—to its eventual demise in Congress. It also will give some reflections on how ANT-OAR promotes a genetically deterministic view of the human organism and can lead down a slippery slope into a future in which human cloning (...)
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  44. ANT-OAR Fails on All Counts: Method of Harvesting Stem Cells Riddled with Scientific and Ethical Flaws.W. Malcolm Byrnes & Jose Granados - 2006 - Science and Theology News (1):23-25.
    The altered nuclear transfer-oocyte assisted reprogramming (ANT-OAR) proposal has serious scientific and philosophical flaws, and it is not a morally acceptable means of obtaining embryonic stem cells. Note that this is the final preprint of an article that was published in the newspaper Science and Theology News in June 2006.
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  45. Confessions of a" pro-life" Obama supporter.W. Malcolm Byrnes - 2009 - The National Catholic Bioethics Quarterly 9 (2):241-244.
    The author supported Barack Obama for president, and he agrees with Obama on most issues. However, he opposes the federal funding of human embryonic stem cell (hESC) research. Besides involving the destruction of human life, hESC research can (1) result in the exploitation of women, and (2) cause human reproduction to become a means to an end, i.e., human embryos will become commodities to be bought and sold. Recent scientific developments show the growing potential of induced pluripotent stem (iPS) cells (...)
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  46. The ecological imperative and its application to ethical issues in human genetic technology.W. Malcolm Byrnes - 2003 - Ethics in Science and Environmental Politics 2003:63-65.
    As a species, we are on the cusp of being able to alter that which makes us uniquely human, our genome. Two new genetic technologies, embryo selection and germline engineering, are either in use today or may be developed in the future. Embryo selection acts to alter the human gene pool, reducing genetic diversity, while germline engineering will have the ability to alter directly the genomes of engineered individuals. Our genome has come to be what it is through an evolutionary (...)
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  47. The Structural Basis for Kinetic and Allosteric Differences between Two Bacterial Phosphofructokinases.W. Malcolm Byrnes - 1994 - Dissertation,
    The fructose 6-phosphate (Fru-6P) saturation curve for phosphofructokinase (PFK) from E. coli is sigmoidal in the presence of saturating MgATP levels, while the corresponding curve for B. stearothermophilus PFK is essentially hyperbolic. Sigmoidality can be due to apparent cooperativity arising from the kinetic mechanism of an enzyme. We have determined the kinetic mechanism of B. stearothermophilus PFK (BsPFK). BsPFK was found to obey a non rapid-equilibrium random mechanism similar to the one E. coli PFK (EcPFK) follows. Substrate inhibition by MgATP (...)
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  48. Death, Dying and Bereavement.Donna Dickenson, Malcolm Johnson & Jeanne Samson Katz (eds.) - 1993 - London: Sage.
    Collection of essays, literature and first-person accounts on death, dying and bereavement.
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  49. Human Genetic Technology, Eugenics, and Social Justice.W. Malcolm Byrnes - 2001 - The National Catholic Bioethics Quarterly 1 (4):555-581.
    In this new post-genomic age of medicine and biomedical technology, there will be novel approaches to understanding disease, and to finding drugs and cures for diseases. Hundreds of new “disease genes” thought to be the causative agents of various genetic maladies will be identified and added to the list of hundreds of such genes already identified. Based on this knowledge, many new genetic tests will be developed and used in genetic screening programs. Genetic screening is the foundation upon which reproductive (...)
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  50. Epigenetics, Evolution, and Us.W. Malcolm Byrnes - 2003 - The National Catholic Bioethics Quarterly 3 (3):489-500.
    This essay moves along broad lines from molecular biology to evolutionary biology and ecology to theology. Its objectives are to: 1) present some recent scientific findings in the emerging field of epigenetics that indicate that it is “the genome in context,” not genes per se, that are important in biological development and evolution; 2) show that this weakens the gene-centric neo-Darwinist explanation of evolution which, in fact, shares a certain preformationist orientation with intelligent design theory; 3) argue that the evidence (...)
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