Reasoning from inconclusive evidence, or ‘induction’, is central to science and any applications we make of it. For that reason alone it demands the attention of philosophers of science. This Element explores the prospects of using probability theory to provide an inductive logic, a framework for representing evidential support. Constraints on the ideal evaluation of hypotheses suggest that overall support for a hypothesis is represented by its probability in light of the total evidence, and incremental support, or confirmation, indicated by (...) an increased probability given the evidence than otherwise. This proposal is shown to have the capacity to reconstruct many canons of the scientific method and inductive inference. Along the way, significant objections are discussed, such as the challenge from inductive scepticism and the objection that the probabilistic approach makes evidential support arbitrary. (shrink)

Evidential support is often equated with confirmation, where evidence supports hypothesis H if and only if it increases the probability of H. This article argues against this received view. As the author shows, support is a comparative notion in the sense that increase-in-probability is not. A piece of evidence can confirm H, but it can confirm alternatives to H to the same or greater degree; and in such cases, it is at best misleading to conclude that the evidence supports H. (...) The author puts forward an alternative view that defines support in terms of measures of degree of confirmation. The proposed view is both sufficiently comparative and able to accommodate the increase-in-probability aspect of support. The author concludes that the proposed measure-theoretic approach to support provides a superior alternative to the standard confirmatory approach. (shrink)

A traditional account of coincidences has it that two facts are coincidental whenever they are not related as cause and effect and do not have a common cause. A recent contribution by Lando : 132–151, 2017) showed that this account is mistaken. In this paper, I argue against two alternative accounts of coincidences, one suggested by Lando, and another by Bhogal : 677–694, 2020), and defend a third one in their place. In short, I propose that how explanatory links relate (...) to non-coincidental facts in explanation is what drives a wedge between coincidences and non-coincidences. This proposal is not susceptible to the worries I raise, and is more general, since it is not restricted to coincidences and non-coincidences involving physical facts. (shrink)

In this paper, I discuss the ways in which epistemic anxiety promotes well-being, specifically by examining the positive contributions that feelings of epistemic anxiety make toward intellectually virtuous inquiry. While the prospects for connecting the concept of epistemic anxiety to the two most prominent accounts of intellectual virtue, i.e., “virtue-reliabilism” and “virtue-responsibilism”, are promising, I primarily focus on whether the capacity for epistemic anxiety counts as an intellectual virtue in the reliabilist sense. As I argue, there is a close yet (...) unexplored connection between feelings of epistemic anxiety and the form of inference commonly known as “Inference to the Best Explanation” (IBE). Specifically, I argue that both the recognition that some fact requires an explanation—a necessary first step in applying IBE—and the subsequent motivation to employ IBE are typically facilitated by feelings of epistemic anxiety. So, provided IBE is truth-conducive the capacity for epistemic anxiety should count as an intellectual virtue in the reliabilist sense. After outlining my main argument, I address the challenge that the capacity for epistemic anxiety has the potential to be misleading. To respond to this challenge, I discuss how our recognition that a fact requires an explanation must in part be a species of practical knowledge, rather than theoretical knowledge. For the agent to skillfully distinguish between facts that require an explanation and facts that do not, she must develop the virtuous disposition to feel the appropriate amount of epistemic anxiety. Despite the many negative aspects associated with anxiety, as I conclude, being disposed to feel the appropriate amount of epistemic anxiety is ultimately good for us. (shrink)

In attempts to compare different distributions with regards to need, so-called “measures of need-based distributive justice” have emerged in recent years. Each of the proposed measures relies on a single dimension of need that is taken into account. This is shown to be problematic since humans experience different kinds of need that appear to be incommensurable. A strategy to deal with this problem is introduced by using multidimensional measures.

This discussion centers on two desiderata: the role of measurement in information-gathering and physical interaction in scientific practice. By taking inspiration from van Fraassen’s view, we present a methodological account of perspectival measurement that addresses empirical practice where there is complex intervention, disagreeing results, and limited theory. The specific aim of our account is to provide a methodological prescription for developing measurement processes in the context of limited theory. The account should be useful to philosophers of science, who are interested (...) in the intersection between representation and intervention; scientists, who are interested in methodological suggestions for theory-development and reliability; and interdisciplinary researchers, who are interested in the intersections between the pandemic, built environments, and social processes. We apply the process-view of measurement to COVID-19, specifically, measuring replication in the SARS-CoV-2 virus. The aim is to show that our account tracks key elements—manipulation/intervention, independence, invariance, and theory-development—by organizing unfolding measurement processes. Additionally, we use our account to make prescriptive suggestions for measurement practice in the COVID-19 context by discussing the need to broaden measurement perspective on interaction, manipulation, and production. (shrink)

Several theistic arguments are formulated as arguments for the best explanation. This article discusses how one can determine that some phenomenon actually needs an explanation. One way to demonstrate that an explanation is needed is by providing one. The proposed explanation ought to either make the occurrence of the phenomenon in question more probable than it occurring by chance, or it has to sufficiently increase our understanding of the phenomenon. A second way to demonstrate that an explanation is needed is (...) to show that the phenomenon in question both violates our expectations and is particularly noticeable. (shrink)

According to the probabilistic relevance account of confirmation, E confirms H relative to background knowledge K just in case P(H/K&E) > P(H/K). This requires an inequality between the rational degree of belief in H determined relative to two bodies of total knowledge which are such that one (K&E) includes the other (K) as a proper part. In this paper, I argue that it is quite plausible that there are no two possible bodies of total knowledge for ideally rational agents meeting (...) this requirement. Hence, the positive relevance account may have to be rejected. (shrink)

While there has been much discussion about what makes some mathematical proofs more explanatory than others, and what are mathematical coincidences, in this article I explore the distinct phenomenon of mathematical facts that call for explanation. The existence of mathematical facts that call for explanation stands in tension with virtually all existing accounts of “calling for explanation”, which imply that necessary facts cannot call for explanation. In this paper I explore what theoretical revisions are needed in order to accommodate this (...) phenomenon. One of the important upshots is that, contrary to the current consensus, low prior probability is not a necessary condition for calling for explanation. In the final section I explain how the results of this inquiry help us make progress in assessing Hartry Field’s style of reliability argument against mathematical Platonism and against robust realism in other domains of necessary facts, such as ethics. (shrink)

This paper proposes an analysis of surprise formulated in terms of proximity to the truth, to replace the probabilistic account of surprise. It is common to link surprise to the low probability of the outcome. The idea seems sensible because an outcome with a low probability is unexpected, and an unexpected outcome often surprises us. However, the link between surprise and low probability is known to break down in some cases. There have been some attempts to modify the probabilistic account (...) to deal with these cases, but as we shall see, they are still faced with problems. The new analysis of surprise I propose turns to accuracy and identifies an unexpected degree of inaccuracy as reason for surprise. The shift from probability to proximity allows us to solve puzzles that strain the probabilistic account of surprise. (shrink)

Varied evidence for a hypothesis confirms it more strongly than less varied evidence, ceteris paribus. This epistemological Variety of Evidence Thesis enjoys long-standing widespread intuitive support. Recent literature has raised serious doubts that the correlational approach of explicating the thesis can vindicate it. By contrast, the eliminative approach due to Horwich vindicates the Variety of Evidence Thesis but only within a relatively narrow domain. I investigate the prospects of extending the eliminative approach to a larger domain by considering a larger (...) class of sensible explications of evidential variety. For a large subclass class of such explications I show how to construct cases in which the less diverse body of evidence for a hypothesis confirms more strongly. I hence argue that these prospects are dire since the eliminative approach widely fails to vindicate the thesis. (shrink)

Two different programmes are in the business of explicating accuracy—the truthlikeness programme and the epistemic utility programme. Both assume that truth is the goal of inquiry, and that among inquiries that fall short of realizing the goal some get closer to it than others. Truthlikeness theorists have been searching for an account of the accuracy of propositions. Epistemic utility theorists have been searching for an account of the accuracy of credal states. Both assume we can make cognitive progress in an (...) inquiry even while falling short of the target. I show that the prospects for combining these two programmes are bleak. A core accuracy principle, proximity, that is universally embraced within the truthlikeness programme turns out to be incompatible with a central principle within the epistemic utility programme, namely propriety. 1Truthlikeness and Epistemic Utility 2Inquiries 3Accuracy for Propositions 4Proximity 5Accuracy for Credal States 6Propriety 7Proximity for Credal States 8Extensionality 9Admissible Weightings 10Propriety Violates Proximity 11Possible Responses 11.1Retreat to convexity 11.2Reject boundedness 11.3Reject additivity 12The Upshot. (shrink)

The concepts of coherence and confirmation are closely intertwined: according to a prominent proposal coherence is nothing but mutual confirmation. Accordingly, it should come as no surprise that both are confronted with similar problems. As regards Bayesian confirmation measures these are illustrated by the problem of tacking by conjunction. On the other hand, Bayesian coherence measures face the problem of belief individuation. In this paper we want to outline the benefit of an approach to coherence and confirmation based on content (...) elements. It will be shown that the resulting concepts, called genuine coherence and genuine confirmation, can be used in order to solve the two mentioned problems. In a final section we present some results on degrees of genuine coherence and genuine confirmation. (shrink)

This article examines the effect of material evidence upon historiographic hypotheses. Through a series of successive Bayesian conditionalizations, I analyze the extended competition among several hypotheses that offered different accounts of the transition between the Bronze Age and the Iron Age in Palestine and in particular to the “emergence of Israel”. The model reconstructs, with low sensitivity to initial assumptions, the actual outcomes including a complete alteration of the scientific consensus. Several known issues of Bayesian confirmation, including the problem of (...) old evidence, the introduction and confirmation of novel theories and the sensitivity of convergence to uncertain and disputed evidence are discussed in relation to the model’s result and the actual historical process. The most important result is that convergence of probabilities and of scientific opinion is indeed possible when advocates of rival hypotheses hold similar judgment about the factual content of evidence, even if they differ sharply in their historiographic interpretation. This speaks against the contention that understanding of present remains is so irrevocably biased by theoretical and cultural presumptions as to make an objective assessment impossible. (shrink)

I consider whether evolutionary explanations can debunk our moral beliefs. Most contemporary discussion in this area is centred on the question of whether debunking implications follow from our ability to explain elements of human morality in terms of natural selection, given that there has been no selection for true moral beliefs. By considering the most prominent arguments in the literature today, I offer reasons to think that debunking arguments of this kind fail. However, I argue that a successful evolutionary debunking (...) argument can be constructed by appeal to the suggestion that our moral outlook reflects arbitrary contingencies of our phylogeny, much as the horizontal orientation of the whale’s tail reflects its descent from terrestrial quadrupeds. An introductory chapter unpacks the question of whether evolutionary explanations can debunk our moral beliefs, offers a brief historical guide to the philosophical discussion surrounding it, and explains what I mean to contribute to this discussion. Thereafter follow six chapters and a conclusion. The six chapters are divided into three pairs. The first two chapters consider what contemporary scientific evidence can tell us about the evolutionary origins of morality and, in particular, to what extent the evidence speaks in favour of the claims on which debunking arguments rely. The next two chapters offer a critique of popular debunking arguments that are centred on the irrelevance of moral facts in natural selection explanations. The final chapters develop a novel argument for the claim that evolutionary explanations can undermine our moral beliefs insofar as they show that our moral outlook reflects arbitrary contingencies of our phylogeny. A conclusion summarizes my argument and sets out the key questions that arise in its wake. (shrink)

The twin goals of this essay are: to investigate a family of cases in which the goal of guaranteed convergence to the truth is beyond our reach; and to argue that each of three strands prominent in contemporary epistemological thought has undesirable consequences when confronted with the existence of such problems. Approaches that follow Reichenbach in taking guaranteed convergence to the truth to be the characteristic virtue of good methods face a vicious closure problem. Approaches on which there is a (...) unique rational doxastic response to any given body of evidence can avoid incoherence only by rendering epistemology a curiously limited enterprise. Bayesian approaches rule out humility about one’s prospects of success in certain situations in which failure is typical. (shrink)

Das Thema dieses Bandes ist die Frage, ob die Wissenschaftstheorie eine normative Disziplin ist. Zunächst überrascht die Frage, denn für viele Wissenschaftstheoretiker ist die Antwort ein klares „Ja“; sie halten es für einen Allgemeinplatz, dass die Wissenschaftstheorie ein normatives Unternehmen ist. Bei genauerem Hinsehen stellt sich jedoch heraus, dass die Frage unterschiedliche Interpretationen zulässt, die einzeln diskutiert werden müssen. Dies geschieht im ersten Abschnitt. Im zweiten Abschnitt suchen wir nach möglichen Erklärungen dafür, warum die Wissenschaftstheorie bisher bei dem Projekt, eine (...) allseits akzeptable Methodologie wissenschaftlichen Schließens zu formulieren und zu begründen, so wenig Erfolg hatte. Eine mögliche Erklärung für den ausbleibenden Erfolg ist der Partikularismus, wonach Methoden keine allgemeine, sondern nur eine lokale, bereichsabhängige Gültigkeit haben. Im dritten Abschnitt wollen wir an Hand des Bayesianismus zeigen, dass die Methodologie doch nicht so schlecht da steht, wie es zunächst den Anschein hat. Der Bayesianismus ist für viele Wissenschaftstheoretiker der aussichtsreichste Kandidat für eine allgemeine Theorie induktiven Räsonierens. Wir besprechen seine Vorzüge, stellen aber auch dar, welche Konzessionen er an den Partikularismus machen muss. (shrink)

The canonical Bayesian solution to the ravens paradox faces a problem: it entails that black non-ravens disconfirm the hypothesis that all ravens are black. I provide a new solution that avoids this problem. On my solution, black ravens confirm that all ravens are black, while non-black non-ravens and black non-ravens are neutral. My approach is grounded in certain relations of epistemic dependence, which, in turn, are grounded in the fact that the kind raven is more natural than the kind black. (...) The solution applies to any generalization “All F’s are G” in which F is more natural than G. (shrink)

What is the metaphysical nature of perceptual experience? What evidence does experience provide us with? These questions are typically addressed in isolation. In order to make progress in answering both questions, perceptual experience needs to be studied in an integrated manner. I develop a unified account of the phenomenological and epistemological role of perceptual experience, by arguing that sensory states provide perceptual evidence due to their metaphysical structure. More specifically, I argue that sensory states are individuated by the perceptual capacities (...) employed and that there is an asymmetric dependence between their employment in perception and their employment in hallucination and illusion. Due to this asymmetric dependence, sensory states provide us with evidence. (shrink)

In this paper, I begin by defending permissivism: the claim that, sometimes, there is more than one way to rationally respond to a given body of evidence. Then I argue that, if we accept permissivism, certain worries that arise as a result of learning that our beliefs were caused by the communities we grew up in, the schools we went to, or other irrelevant influences dissipate. The basic strategy is as follows: First, I try to pinpoint what makes irrelevant influences (...) worrying and I come up with two candidate principles. I then argue that one principle should be rejected because it is inconsistent with permissivism. The principle we should accept implies that it is sometimes rational to maintain our beliefs, even upon learning that they were caused by irrelevant influences. (shrink)

Probability ratio and likelihood ratio measures of inductive support and related notions have appeared as theoretical tools for probabilistic approaches in the philosophy of science, the psychology of reasoning, and artificial intelligence. In an effort of conceptual clarification, several authors have pursued axiomatic foundations for these two families of measures. Such results have been criticized, however, as relying on unduly demanding or poorly motivated mathematical assumptions. We provide two novel theorems showing that probability ratio and likelihood ratio measures can be (...) axiomatized in a way that overcomes these difficulties. (shrink)

There are different Bayesian measures to calculate the degree of confirmation of a hypothesis H in respect of a particular piece of evidence E. Zalabardo (Analysis 69:630–635, 2009) is a recent attempt to defend the likelihood-ratio measure (LR) against the probability-ratio measure (PR). The main disagreement between LR and PR concerns their sensitivity to prior probabilities. Zalabardo invokes intuitive plausibility as the appropriate criterion for choosing between them. Furthermore, he claims that it favours the ordering of pairs evidence/hypothesis generated by (...) LR. We will argue, however, that the intuitive non-numerical example provided by Zalabardo does not show that prior probabilities do not affect the degree of confirmation. On account of this, we conclude that there is no compelling reason to endorse LR qua measure of degree of confirmation. On the other side, we should not forget some technicalities which still benefit PR. (shrink)

Among Bayesian confirmation theorists, several quantitative measures of the degree to which an evidential proposition E confirms a hypothesis H have been proposed. According to one popular recent measure, s, the degree to which E confirms H is a function of the equation P(H|E) − P(H|~E). A consequence of s is that when we have two evidential propositions, E1 and E2, such that P(H|E1) = P(H|E2), and P(H|~E1) ≠ P(H|~E2), the confirmation afforded to H by E1 does not equal the (...) confirmation afforded to H by E2. I present several examples that demonstrate the unacceptability of this result, and conclude that we should reject s (and other measures that share this feature) as a measure of confirmation. (shrink)

The judgment that a given event is epistemically improbable is necessary but insufficient for us to conclude that the event is surprising. Paul Horwich has argued that surprising events are, in addition, more probable given alternative background assumptions that are not themselves extremely improbable. I argue that Horwich’s definition fails to capture important features of surprises and offer an alternative definition that accords better with intuition. An important application of Horwich’s analysis has arisen in discussions of fine-tuning arguments. In the (...) second part of the paper I consider the implications for this argument of employing my definition of surprise. I argue that advocates of fine-tuning arguments are not justified in attaching significance to the fact that we are surprised by examples of fine-tuning. (shrink)

Formally-inclined epistemologists often theorize about ideally rational agents--agents who exemplify rational ideals, such as probabilistic coherence, that human beings could never fully realize. This approach can be defended against the well-know worry that abstracting from human cognitive imperfections deprives the approach of interest. But a different worry arises when we ask what an ideal agent should believe about her own cognitive perfection (even an agent who is in fact cognitively perfect might, it would seem, be uncertain of this fact). Consideration (...) of this question reveals an interesting feature of the structure of our epistemic ideals: for agents with limited information, our epistemic ideals turn out to conflict with one another. (shrink)

Starting from the sixties of the past century theory change has become a main concern of philosophy of science. Two of the best known formal accounts of theory change are the post-Popperian theories of verisimilitude (PPV for short) and the AGM theory of belief change (AGM for short). In this paper, we will investigate the conceptual relations between PPV and AGM and, in particular, we will ask whether the AGM rules for theory change are effective means for approaching the truth, (...) i.e., for achieving the cognitive aim of science pointed out by PPV. First, the key ideas of PPV and AGM and their application to a particular kind of propositional theories - the so called "conjunctive propositions" - will be illustrated. Afterwards, we will prove that, as far as conjunctive propositions are concerned, AGM belief change is an effective tool for approaching the truth. (shrink)

Sometimes we learn what the world is like, and sometimes we learn where in the world we are. Are there any interesting differences between the two kinds of cases? The main aim of this article is to argue that learning where we are in the world brings into view the same kind of observation selection effects that operate when sampling from a population. I will first explain what observation selection effects are ( Section 1 ) and how they are relevant (...) to learning where we are in the world ( Section 2 ). I will show how measurements in the Many Worlds Interpretation of quantum mechanics can be understood as learning where you are in the world via some observation selection effect ( Section 3 ). I will apply a similar argument to the Sleeping Beauty Problem ( Section 4 ) and explain what I take the significance of the analogy to be ( Section 5 ). Finally, I will defend the Restricted Principle of Indifference on which some of my arguments depend ( Section 6 ). (shrink)

According to Hempel's paradox, evidence (E) that an object is a nonblack nonraven confirms the hypothesis (H) that every raven is black. According to the standard Bayesian solution, E does confirm H but only to a minute degree. This solution relies on the almost never explicitly defended assumption that the probability of H should not be affected by evidence that an object is nonblack. I argue that this assumption is implausible, and I propose a way out for Bayesians. Introduction Hempel's (...) paradox, the standard Bayesian solution, and the disputed assumption Attempts to defend the disputed assumption Attempts to refute the disputed assumption A way out for Bayesians Conclusion. (shrink)

That all subjunctive conditionals with true antecedents and trueconsequents are themselves also true is implied by every plausibleand popularly endorsed account. But I am wary of endorsing thisimplication. I argue that all presently endorsed accounts fail tocapture the nature of certain subjunctive conditionals in contextsof consequentialist reasoning. I attempt to show that we must allowfor the possibility that some subjunctive conditionals with trueantecedents and true consequents are false, if we are to believethat certain types of straightforward consequentialist reasoningare coherent. I (...) begin by evaluating a pair of morally releventcounterfactuals in a case via David Lewis's account. I then turnto a slight modification of the case, arguing that Lewis'ssemantics fails to generate the correct truth values of thesubjunctive conditionals in the modified case. Finally, I presenta modified version of Lewis's semantics that generates the correctresults in all of the cases. (shrink)

Despite the widespread use of key concepts of the Neyman–Pearson (N–P) statistical paradigm—type I and II errors, significance levels, power, confidence levels—they have been the subject of philosophical controversy and debate for over 60 years. Both current and long-standing problems of N–P tests stem from unclarity and confusion, even among N–P adherents, as to how a test's (pre-data) error probabilities are to be used for (post-data) inductive inference as opposed to inductive behavior. We argue that the relevance of error probabilities (...) is to ensure that only statistical hypotheses that have passed severe or probative tests are inferred from the data. The severity criterion supplies a meta-statistical principle for evaluating proposed statistical inferences, avoiding classic fallacies from tests that are overly sensitive, as well as those not sensitive enough to particular errors and discrepancies. Introduction and overview 1.1 Behavioristic and inferential rationales for Neyman–Pearson (N–P) tests 1.2 Severity rationale: induction as severe testing 1.3 Severity as a meta-statistical concept: three required restrictions on the N–P paradigm Error statistical tests from the severity perspective 2.1 N–P test T(): type I, II error probabilities and power 2.2 Specifying test T() using p-values Neyman's post-data use of power 3.1 Neyman: does failure to reject H warrant confirming H? Severe testing as a basic concept for an adequate post-data inference 4.1 The severity interpretation of acceptance (SIA) for test T() 4.2 The fallacy of acceptance (i.e., an insignificant difference): Ms Rosy 4.3 Severity and power Fallacy of rejection: statistical vs. substantive significance 5.1 Taking a rejection of H0 as evidence for a substantive claim or theory 5.2 A statistically significant difference from H0 may fail to indicate a substantively important magnitude 5.3 Principle for the severity interpretation of a rejection (SIR) 5.4 Comparing significant results with different sample sizes in T(): large n problem 5.5 General testing rules for T(), using the severe testing concept The severe testing concept and confidence intervals 6.1 Dualities between one and two-sided intervals and tests 6.2 Avoiding shortcomings of confidence intervals Beyond the N–P paradigm: pure significance, and misspecification tests Concluding comments: have we shown severity to be a basic concept in a N–P philosophy of induction? (shrink)

Hempel first introduced the paradox of confirmation in (Hempel 1937). Since then, a very extensive literature on the paradox has evolved (Vranas 2004). Much of this literature can be seen as responding to Hempel’s subsequent discussions and analyses of the paradox in (Hempel 1945). Recently, it was noted that Hempel’s intuitive (and plausible) resolution of the paradox was inconsistent with his official theory of confirmation (Fitelson & Hawthorne 2006). In this article, we will try to explain how this inconsistency affects (...) the historical dialectic about the paradox and how it illuminates the nature of confirmation. In the end, we will argue that Hempel’s intuitions about the paradox of confirmation were (basically) correct, and that it is his theory that should be rejected, in favor of a (broadly) Bayesian account of confirmation. (shrink)

An improvement on Horwich's so-called pseudo-proof of Russell 's principle of induction is offered, which, we believe, avoids certain objections to the former. Although strictly independent of our other work in this area, a connection can be made and in the final section we comment on this and certain questions regarding rationality, etc.

In 1947 Donald Cary Williams claimed in The Ground of Induction to have solved the Humean problem of induction, by means of an adaptation of reasoning first advanced by Bernoulli in 1713. Later on David Stove defended and improved upon Williams’ argument in The Rational- ity of Induction (1986). We call this proposed solution of induction the ‘Williams-Stove sampling thesis’. There has been no lack of objections raised to the sampling thesis, and it has not been widely accepted. In our (...) opinion, though, none of these objections has the slightest force, and, moreover, the sampling thesis is undoubtedly true. What we will argue in this paper is that one particular objection that has been raised on numerous occasions is misguided. This concerns the randomness of the sample on which the inductive extrapolation is based. (shrink)

In biomedical measurement, biomarkers are used to achieve reliable prediction of, and useful causal information about patient outcomes while minimizing complexity of measurement, resources, and invasiveness. A biomarker is an assayable metric that discloses the status of a biological process of interest, be it normative, pathophysiological, or in response to intervention. The greatest utility from biomarkers comes from their ability to help clinicians (and researchers) make and evaluate clinical decisions. In this paper we discuss a specific methodological use of clinical (...) biomarkers in pharmacological measurement: Some biomarkers, called ‘surrogate markers’, are used to substitute for a clinically meaningful endpoint corresponding to events and their penultimate risk factors. We confront the reliability of clinical biomarkers that are used to gather information about clinically meaningful endpoints. Our aim is to present a systematic methodology for assessing the reliability of multiple surrogate markers (and biomarkers in general). To do this we draw upon the robustness analysis literature in the philosophy of science and the empirical use of clinical biomarkers. After introducing robustness analysis we present two problems with biomarkers in relation to reliability. Next, we propose an intervention-based robustness methodology for organizing the reliability of biomarkers in general. We propose three relevant conditions for a robust methodology for biomarkers: (R1) Intervention-based demonstration of partial independence of modes: In biomarkers partial independence can be demonstrated through exogenous interventions that modify a process some number of “steps” removed from each of the markers. (R2) Comparison of diverging and converging results across biomarkers: By systematically comparing partially-independent biomarkers we can track under what conditions markers fail to converge in results, and under which conditions they successfully converge. (R3) Information within the context of theory: Through a systematic cross-comparison of the markers we can make causal conclusions as well as eliminate competing theories. We apply our robust methodology to currently developing Alzheimer’s research to show its usefulness for making causal conclusions. (shrink)

This article defends the Doomsday Argument, the Halfer Position in Sleeping Beauty, the Fine-Tuning Argument, and the applicability of Bayesian confirmation theory to the Everett interpretation of quantum mechanics. It will argue that all four problems have the same structure, and it gives a unified treatment that uses simple models of the cases and no controversial assumptions about confirmation or self-locating evidence. The article will argue that the troublesome feature of all these cases is not self-location but selection effects.

This paper examines the standard Bayesian solution to the Quine–Duhem problem, the problem of distributing blame between a theory and its auxiliary hypotheses in the aftermath of a failed prediction. The standard solution, I argue, begs the question against those who claim that the problem has no solution. I then provide an alternative Bayesian solution that is not question-begging and that turns out to have some interesting and desirable properties not possessed by the standard solution. This solution opens the way (...) to a satisfying treatment of a problem concerning ad hoc auxiliary hypotheses. (shrink)

It is notoriously difficult to spell out the norms of inductive reasoning in a neat set of rules. I explore the idea that explanatory considerations are the key to sorting out the good inductive inferences from the bad. After defending the crucial explanatory virtue of stability, I apply this approach to a range of inductive inferences, puzzles, and principles such as the Raven and Grue problems, and the significance of varied data and random sampling.

According to Bayesian epistemology, the epistemically rational agent updates her beliefs by conditionalization: that is, her posterior subjective probability after taking account of evidence X, pnew, is to be set equal to her prior conditional probability pold(·|X). Bayesians can be challenged to provide a justification for their claim that conditionalization is recommended by rationality—whence the normative force of the injunction to conditionalize? There are several existing justifications for conditionalization, but none directly addresses the idea that conditionalization will be epistemically rational (...) if and only if it can reasonably be expected to lead to epistemically good outcomes. We apply the approach of cognitive decision theory to provide a justification for conditionalization using precisely that idea. We assign epistemic utility functions to epistemically rational agents; an agent’s epistemic utility is to depend both upon the actual state of the world and on the agent’s credence distribution over possible states. We prove that, under independently motivated conditions, conditionalization is the unique updating rule that maximizes expected epistemic utility. (shrink)

What is the relation or connection between formalizations of induction and the actual inductive inferences of scientists? Building from recent works in the philosophy of logic, this paper argues that these formalizations of induction are best viewed as models and not literal descriptions of inductive inferences in science. Three arguments are put forward to support this claim. First, I argue that inductive support is the kind of phenomenon that can be justifiably modeled. Second, I argue that these formalizations have the (...) features that define models—that they have representors, artefacts, and idealizations. Third, I argue that these formalizations being models explains their plurality and revisability. (shrink)

In addition to purely practical values, cognitive values also figure into scientific deliberations. One way of introducing cognitive values is to consider the cognitive value that accrues to the act of accepting a hypothesis. Although such values may have a role to play, such a role does not exhaust the significance of cognitive values in scientific decision-making. This paper makes a plea for consideration of epistemic value —that is, value attaching to a state of belief—and defends the notion of cognitive (...) epistemic value against some criticisms that have been raised. A stability requirement for epistemic value functions is argued for on the basis of considerations of diachronic coherence. This stability requirement is sufficient to obtain the Value of Learning Theorem, which says that the expected utility of cost-free learning cannot be negative. This holds also for cognitive epistemic values, provided that the stability requirement is met. (shrink)

I present a justification for the intution that more-varied data are more valuable than the same number of less-varied data by showing that the more-varied data help to improve the accuracy of our predictions.