Was ist Natur oder was könnte sie sein? Diese und weitere Fragen sind grundlegend für Naturdenken und -handeln. Das Lehr- und Studienbuch bietet eine historisch-systematische und zugleich praxisbezogene Einführung in die Naturphilosophie mit ihren wichtigsten Begriffen. Es nimmt den pluralen Charakter der Wahrnehmung von Natur in den philosophischen Blick und ist auch zum Selbststudium bestens geeignet.

This study aims to investigate the relationship between job burnout and employee performance in the feed industry during the ASF outbreak. Further, the researchers employed a descriptive-correlational research design in order to analyze the acquired data and produce pertinent findings. Thus, the researchers gathered data from one hundred two (102) feed industry employees. The Maslach Burnout Inventory (MBI) and Individual Work Performance Questionnaire (IWPQ) were employed to ascertain the extent of job burnout experienced by the respondents and evaluate employee performance, (...) respectively. Based on the statistical analysis, there is a significant relationship between job burnout and employee performance. Moreover, the study's findings were thoroughly analyzed and discussed. (shrink)

The abrupt shift in learning mode demands students to adjust from the comfort of their homes, as well as the challenges of face-to-face learning. As a result, as the pandemic fades, institutions in the Philippines have begun to reopen their doors to students. Hence, this study employed a correlational design to investigate the relationship between procrastination and academic burnout among 150 first-year college students in a state university. Based on the statistical analysis, the r coefficient of 0.67 indicates a moderate (...) positive correlation between the variables. The p-value of 0.00, which is less than 0.05, leads to the decision to reject the null hypothesis. Hence, a significant relationship exists between procrastination and academic burnout among first-year college students. Implications and recommendations were discussed in the study. (shrink)

The precarious rights of senior citizens, especially those who are highly educated and who are expected to counsel and guide the younger generations, has stimulated the creation internationally of advocacy associations and opinion leader groups. The strength of these groups, however, varies from country to country. In some countries, they are supported and are the focus of intense interest; in others, they are practically ignored. For this is reason we believe that the creation of a network of all these associations (...) is essential. The proposed network would act as a support for the already-existing policies of the United Nations’ High Commission for Human Rights, of independent experts, and of the Global Alliance for the Rights of Older People. All three have long ago recommended the creation of a recognized instrument for uniting presently scattered efforts. The proposed network, therefore, will seek to promote the international exchange of relevant expertise, and it will reinforce the commitments and actions that single countries are currently taking to meet these objectives. For example, informative public events can be organised to promote particular support initiatives and to provide an opportunity for new members of the network to be presented. The network will promote health for senior citizens, disease prevention, senior mobility, safe free time for seniors, alimentary education, protection against new risks and dangers, as well as equity in the services necessary for seniors to adopt new information and communication technologies. In the case of retired academic members, the network will promote equality with respect to continuing use of digital technologies (particularly email), continuing access to research libraries, and the guaranteed ability for seniors to fund their own research programs and to deliver free seminars. (shrink)

Modular learning was used to assist elementary learners in continuing their education during the pandemic. This modular learning posed academic challenges. This phenomenological study delved into the academic challenges of modular learning of public-school elementary school learners. Validated In-depth interview protocol (IDI) was used to collect the data from ten (10) Grade six learners. Findings revealed that these academic challenges include unfavorable learning environments, reading comprehension issues, lack of motivation, and poor quality of printed learning modules that affect the learners (...) ability to comprehend and finish the module effectively. Consequently, modular learning allows learners to take responsibility for their learning by utilizing the available answers key, optimizing internet usage, scheduling time properly, and guessing answers. Considerably, the learners used face-to-face conversations, personal messages, and phone calls to communicate their educational queries. Moreover, the structure of self-learning modules facilitates independent study and complicates learners understanding. It is recommended that there is a need to enhance policies for improving module quality, allocate sufficient funds to improve the printed module quality, conduct relevant teacher training and workshops for developing quality printed modules, and sustain the home visitation program to monitor students modular learning progress. (shrink)

Die vorliegende Schrift unternimmt eine Revision des vorherrschenden Bildes der Rolle und der Konzeptionen von Moral und Ethik im Wiener Kreis. Dieses Bild wird als zu einseitig und undifferenziert zurückgewiesen. Die Ansicht, die Mitglieder des Wiener Kreises hätten kein Interesse an Moral und Ethik gezeigt, wird widerlegt. Viele Mitglieder waren nicht nur moralisch und politisch interessiert, sondern auch engagiert. Des Weiteren vertraten nicht alle die Standardauffassung logisch-empiristischer Ethik, die neben der Anerkennung deskriptiv-empirischer Untersuchungen durch die Ablehnung jeglicher normativer und inhaltlicher (...) Ethik und der Verfechtung eines extremen Nonkognitivismus geprägt ist. Am meisten entspricht die Standardauffassung den Ansichten Rudolf Carnaps, weniger bereits jenen Karl Mengers, Otto Neuraths oder Philipp Franks. Am weitesten weichen Moritz Schlick, Victor Kraft sowie Herbert Feigl von der Standardauffassung ab. Entgegen dem herkömmlichen Bild weltabgewandter Logiker und Metaethiker wurde im Wiener Kreis sogar Angewandte Ethik betrieben, und dies bereits unter diesem Namen. Neben den ethischen Hauptthemen und Ansichten der jeweiligen Philosophen in ihrer Entwicklung im Rahmen ihres persönlichen und kulturellen Kontextes zeigt die Untersuchung, dass allen Ansätzen eine aufgeklärte und humanistische Version von Moral und Ethik gemeinsam ist. Dieser wissenschaftliche Humanismus, der sich schon in der Programmschrift Wissenschaftliche Weltauffassung. Der Wiener Kreis findet, liegt jedoch in verschiedenen Ausprägungen vor. Was die Abweichungen von der Standardauffassung wesentlich betrifft, ist ihre unterschiedliche Auffassung von Moral als gemeinsames oder individuelles Unternehmen. Carnap führt ein extremer Individualismus zu einem extremen Nonkognitivismus, in dem ihm Menger folgt. Bei Schlick ist die Lage zweideutig, was sich in unterschiedlichen Moralbegriffen widerspiegelt. Bei Kraft und Feigl tritt das Verständnis von Moral als gemeinschaftlich geteilte Praxisform klar hervor. Auf der Basis eines gemeinsamen Begriffs des moralisch Guten, der auch eine Sachkomponente enthält, ist eine Verständigung über moralische Fragen möglich. Von einem extremen Nonkognitivismus kann dort nicht mehr die Rede sein. Mit diesen Ergebnissen verbietet es sich, dem Wiener Kreis allgemein eine Ablehnung normativer Ethik und einen extremen Nonkognitivismus zuzuschreiben. Eine systematische Ethik, die Moral als Gemeinschaftspraxis begreift, steht einigen im Wiener Kreis näher, als das vorherrschende Bild suggerieren möge. Wer meint, mit engem Bezug zur Tradition des Wiener Kreises nur Carnap folgen zu können und Ethik als suspektes Unternehmen betrachten zu müssen, irrt. Ethik war in der Tradition Analytischer Philosophie nicht immer so marginalisiert, wie sie es in manchen ihrer Teilrichtungen heute noch ist und Gegner(innen) der Analytischen Philosophie vorwerfen. Die vorliegende Untersuchung liefert die nötige Revision einer verfänglichen Fehlentwicklung. (shrink)

Erarbeitet von Dominik Balg, Anne Burkard, Henning Franzen, Aenna Frottier, David Lanius, David Löwenstein, Hanna Lucks, Kirsten Meyer, Donata Romizi, Katharina Schulz, Stefanie Thiele und Annett Wienmeister. -/- Die Entwicklung argumentativer Fähigkeiten ist ein zentrales Ziel des Ethik- und Philosophieunterrichts, ja überhaupt ein zentrales Bildungsziel. Wie aber kann das gelingen? In vielen verfügbaren Unterrichtsmaterialien werden argumentative Fähigkeiten eher vorausgesetzt als systematisch gefördert. Auch curriculare Vorgaben bleiben zumeist sehr unspezifisch. Lehrpersonen werden so weitgehend allein gelassen mit der Aufgabe, Lernende beim Erwerb (...) argumentativer Fähigkeiten zu fördern. Die vorliegende Aufgabensammlung soll dazu beitragen, diese Lücke zu schließen. Sie bietet Lehrpersonen reichhaltige Materialien für die spiralcurricular angelegte, systematische Förderung argumentativer Fähigkeit anhand exemplarischer Inhalte. Orientiert an klaren fachlichen Standards finden sich hier Aufgaben auf vier Niveaustufen, jeweils in Verbindung mit übersichtlichen Merkblättern. Die Aufgaben der beiden unteren Niveaustufen lassen sich bereits für jüngere Lernende der Sekundarstufe einsetzen, Aufgaben der obersten Niveaustufe richten sich an Lernende von Abschlussklassen oder der Studieneingangsphase. Für die Hand der Lehrpersonen werden die Aufgaben und Merkblätter durch fachliche und didaktische Kommentare sowie Lösungshinweise ergänzt. (shrink)

Das deutsche Gesundheitswesen steht durch die schnell steigende Anzahl an CO- VID-19-Erkrankten vor erheblichen Herausforderungen. In dieser Krisensituation sind alle Beteiligten mit ethischen Fragen konfrontiert, beispielsweise nach gerech- ten Verteilungskriterien bei begrenzten Ressourcen und dem gesundheitlichen Schutz des Personals angesichts einer bisher nicht therapierbaren Erkrankung. Daher werden schon jetzt klinische und ambulante Ethikberatungsangebote verstärkt mit Anfragen nach Unterstützung konfrontiert. Wie können Ethikberater*innen Entscheidungen in der Krankenversorgung im Rahmen der COVID-19-Pandemie unterstützen? Welche Grenzen von Ethikberatung sind zu beachten? Bislang liegen hierzu (...) noch wenige praktische Erfahrungen vor. Angesichts der dynamischen Entwicklung erscheint es der Akademie für Ethik in der Medizin (AEM) wichtig, einen Diskurs über die angemessene Rolle der Ethikberatung bei der Bewältigung der vielfachen Heraus- forderungen durch die COVID-19-Pandemie zu führen und professionelle Hinweise zu geben. Mit dem vorliegenden Diskussionspapier möchte die AEM einen Beitrag zur Beantwortung wesentlicher Fragen leisten, die sich für die Ethikberatung in den verschiedenen Bereichen des Gesundheitswesens stellen. Sie regt an, diesen Dis- kurs weiter zu führen und hat ein Online-Forum (s. unten) eingerichtet, in dem Ethikberater*innen ihre Erfahrungen teilen und die professionelle Selbstreflexion der Ethikberatung in Pandemiezeiten mit Anregungen fördern können. (shrink)

Die Frage nach der Verantwortung für globale Armut laesst sich auf mindestens zwei Weisen stellen – als Frage nach der (retrospektiven) Verantwortung für das Auftreten dieses Problems oder als Frage nach der (prospektiven) Verantwortung für dessen Behebung. Dieses Kapitel wird sich vor allem auf die zweite Frage konzentrieren: Inwiefern sollte die Verantwortung, Armut zu bekaempfen, als kollektive Verantwortung verstanden werden? Für viele von uns werden diese Pflichten nur im weiten (schwachen) Sinne kollektiv sein, naemlich in dem Sinne, dass die kollektive (...) Ebene für die Entscheidungsfindung und die Handlungsbewertung primaer ist. Kollektivitaet von Verantwortung im engen Sinn erfordert hingegen staerkere epistemische Verknüpfungen der Gruppenmitglieder sowie eine Bekenntnis zum gemeinsamen Ziel. Wo diese bereits bestehen, da koennen wir von kollektiver Verantwortung in diesem starken Sinn sprechen und entsprechend von den Mitgliedern dieser Gruppen einen groesseren Einsatz für das Endresultat erwarten. (shrink)

This dissertation examines the influence of Cambridge Platonism and materialist philosophy on Mary Astell's early feminism. More specifically, I argue that Astell co-opts Descartes's theory of regulating the passions in his final publication, The Passions of the Soul, to articulate a comprehensive, Enlightenment and body friendly theory of feminine self-esteem that renders her feminism modern. My analysis of Astell's theory of feminine self-esteem follows both textual and contextual cues, thus allowing for a reorientation of her early feminism vis-a-vis contemporary feminist (...) theory . An entire chapter in the dissertation is devoted to Astell's use of Descartes's theory of regulating the passions to render women more substantial and inherently worthy. This rendering becomes more concrete in Astell's feminist framework as she employs the language of the social contract in her fourth publication, Reflections Upon Marriage, to depict wives as contractual slaves. I argue that her assertion concerning women's slavery is theoretically consistent when read in light of her theory of feminine self-esteem, since this theory is based on the Enlightenment principles of self-mastery, independence and self-preservation. Further, I align Astell's early feminism in a dialogic sense with the Continental "querelle des femmes," especially as presented in writings by Christine de Pizan and Agrippa. Astell, I argue, contributes to the "querelle" by framing the feminist problem she wishes to solve concerning women's equality in a robust , philosophical manner that uncannily prefigures Wollstonecraft's call for the universalization of human virtues and the reform of of women's education. (shrink)

In this review, we describe some of the central philosophical issues facing origins-of-life research and provide a targeted history of the developments that have led to the multidisciplinary field of origins-of-life studies. We outline these issues and developments to guide researchers and students from all fields. With respect to philosophy, we provide brief summaries of debates with respect to (1) definitions (or theories) of life, what life is and how research should be conducted in the absence of an accepted theory (...) of life, (2) the distinctions between synthetic, historical, and universal projects in origins-of-life studies, issues with strategies for inferring the origins of life, such as (3) the nature of the first living entities (the “bottom up” approach) and (4) how to infer the nature of the last universal common ancestor (the “top down” approach), and (5) the status of origins of life as a science. Each of these debates influences the others. Although there are clusters of researchers that agree on some answers to these issues, each of these debates is still open. With respect to history, we outline several independent paths that have led to some of the approaches now prevalent in origins-of-life studies. These include one path from early views of life through the scientific revolutions brought about by Linnaeus (von Linn.), Wöhler, Miller, and others. In this approach, new theories, tools, and evidence guide new thoughts about the nature of life and its origin.We also describe another family of paths motivated by a” circularity” approach to life, which is guided by such thinkers as Maturana & Varela, Gánti, Rosen, and others. These views echo ideas developed by Kant and Aristotle, though they do so using modern science in ways that produce exciting avenues of investigation. By exploring the history of these ideas, we can see how many of the issues that currently interest us have been guided by the contexts in which the ideas were developed. The disciplinary backgrounds of each of these scholars has influenced the questions they sought to answer, the experiments they envisioned, and the kinds of data they collected. We conclude by encouraging scientists and scholars in the humanities and social sciences to explore ways in which they can interact to provide a deeper understanding of the conceptual assumptions, structure, and history of origins-of-life research. This may be useful to help frame future research agendas and bring awareness to the multifaceted issues facing this challenging scientific question. (shrink)

Die Debatte um die Differenz von „Verantwortung“ und „Pflicht“ ist kein bloßer Streit um Wörter, geht es doch um Begriffe, für die der Anspruch erhoben wird, sie seien konstitutiv für moralische Normativität oder gar für Normativität per se. Doch welchen Unterschied macht es, die besondere Bindungskraft von Normativität über Verantwortung oder über Pflicht zu explizieren? Die Genealogie der philosophischen Reflexionen auf Verantwortung lokalisiert die Differenz zwischen Pflicht und Verantwortung in den jeweiligen Selbstverhältnissen, die mit diesen Begriffen verbunden werden. Die Analyse (...) der Struktur dieser Selbstverhältnisse erklärt sowohl, warum Verantwortung häufig als moderner Ersatzbegriff für Pflicht gedacht wird, als auch, welchen Unterschied die Explikation der Bindungskraft von Normativität über Verantwortung oder Pflicht macht: Je nachdem, mit welchem Begriff normative Kraft erläutert wird, wandert das entsprechende Selbstverhältnis in die Verfasstheit von Normativität ein. (shrink)

Feminism and Tradition in Aesthetics takes a fresh look at the history of aesthetics and at current debates within the philosophy of art by exploring the ways in which gender informs notions of art and creativity, evaluation and interpretation, and concepts of aesthetic value. Multiple intellectual traditions have formed this field, and the discussions herein range from consideration of eighteenth century legacies of ideas about taste, beauty, and sublimity to debates about the relevance of postmodern analyses for feminist aesthetics. Forward (...) by Arthur C. Danto, 20 authors include Paul Mattick, Jr., Caroline Korsmeyer, Timothy Gould, Christine Battersby, Mary Devereaux, bell hooks, REnee Lorraine, Trinh T. Minh-ha, Elizabeth Ann Dobie, Adrian Piper, Anita Silvers, Susan Feagin, Mary D. Garrard, Ellen Handler Spitz, Noel Carroll, Joanne Waugh, Joseph Margolis, Rita Felski, and Hilde Hein, as well as Peg Brand's essay, "Revising the Aesthetic-Nonaesthetic Distinction: The Aesthetic Value of Activist Art.". (shrink)

Farben sind für uns sowohl objektive, als auch phänomenale Eigenschaften. In seinem Buch argumentiert Fabian Dorsch, daß keine ontologische Theorie der Farben diesen beiden Seiten unseres Farbbegriffes gerecht werden k ann. Statt dessen sollten wir akzeptieren, daß letzterer sich auf zwei verschiedene Arten von Eigenschaften bezieht: die repräsentierten Reflektanzeigenschaften von Gegenständen und die qualitativen Eigenschaften unserer Farbwahrnehmungen, die als sinnliche Gegebenheitsweisen ersterer fungieren. Die Natur der Farben gibt einen detaillierten Überblick über die zeitgenössischen philosophischen und naturwissenschaftlichen Theorien der Farben und (...) bietet sich aufgrund seines systematischen und umfassenden Charakters auch als ein seminar- oder vorlesungsbegleitendes Textbuch an. (shrink)

Die Moralphilosophie des 20. und 21. Jahrhunderts hat mit Konsequentialismus, Deontologie, Kontraktualismus und Tugendethik nicht nur höchst einflussreiche Theorieparadigmen produktiv weiterentwickelt, sondern auch eine Reihe wichtiger neuer Probleme aufgeworfen. Der vorliegende Band versammelt zentrale Beiträge der analytischen Moralphilosophie, u. a. von David Gauthier, Shelly Kagan, Frances Kamm, Thomas Nagel, Michael Slote, Christine Swanton und Susan Wolf, die für ein Verständnis gegenwärtiger Diskussionen in der normativen Ethik unabdingbar sind. -/- Inhaltsverzeichnis: Vorwort Einleitung: Analytische Moralphilosophie der Gegenwart -/- 1. Konsequentialismus Shelly Kagan: (...) Ein Plädoyer gegen die Alltagsmoral Peter Railton: Entfremdung, Konsequentialismus und die Anforderungen der Moral -/- 2. Deontologie Thomas Nagel: Ethik William David Ross: Was macht richtige Handlungen richtig? -/- 3. Kontraktualismus David Gauthier: Warum Kontraktualismus? Thomas Scanlon: Die Struktur des Kontraktualismus -/- 4. Tugendethik Christine Swanton: Eine tugendethische Theorie des richtigen Handelns Michael Slote: Akteursbasierte Tugendethik -/- 5. Moralische Aggregation John Taurek: Zählt die Anzahl? Frances M. Kamm: Aggregation und zwei moralphilosophische Methoden -/- 6. Das Prinzip der Doppelwirkung Jonathan Bennett: Vorhergesehene Nebenwirkungen vs. beabsichtigte Folgen Ralph Wedgwood: Zur Verteidigung der Lehre von der Doppelwirkung -/- 7. Moralische Rechte H. L. A. Hart: Gibt es natürliche Rechte? Joseph Raz: Über die Beschaffenheit von Rechten -/- 8. Moralischer Zufall Thomas Nagel: Moralischer Zufall Susan Wolf: Die Moral des moralischen Zufalls. (shrink)

DESENVOLVIMENTO EMBRIONÁRIO E DIFERENCIAÇÃO SEXUAL -/- E. I. C. da Silva Departamento de Agropecuária – IFPE Campus Belo Jardim Departamento de Zootecnia – UFRPE sede -/- 1.1 INTRODUÇÃO O sexo foi definido como a soma das diferenças morfológicas, fisiológicas e psicológicas que distinguem o macho da fêmea permitindo a reprodução sexual e assegurando a continuidade das espécies. Os processos de diferenciação sexual são realizados durante o desenvolvimento embrionário, onde ocorre a proliferação, diferenciação e maturação das células germinativas e primordiais, precursoras (...) de ovócitos e espermatozoides em fêmeas e machos, respectivamente. Assim, os embriões machos e fêmeas iniciam o seu desenvolvimento de forma semelhante, de modo que em ambos os sexos se estabelecem em estruturas idênticas a partir das quais se formarão os órgãos reprodutores correspondentes a cada sexo. O conhecimento da origem e do desenvolvimento do aparelho genital é indispensável para entender sua função e as alterações que produzem infertilidade ou esterilidade. 1.2 DETERMINAÇÃO DO SEXO CROMOSSÔMICO Nos mamíferos, o sexo cromossômico é determinado no momento da fertilização, quando um óvulo, que contém um cromossomo X, é fecundado por um espermatozoide portador de um cromossomo X ou um cromossomo Y. No primeiro caso, o complemento cromossômico seria XX, o que originaria uma fêmea (sexo homogamético), e no segundo daria como resultado um macho com a fórmula cromossômica XY (sexo heterogâmico). 1.3 A GÔNADA INDIFERENCIADA A primeira manifestação das gônadas se aprecia no embrião em forma de um par de eminências longitudinais chamadas cristas ou dobras gonodais, situadas em ambos os lados da linha média entre os mesonefros (rins em desenvolvimento) e do mesentério dorsal. Nos embriões dos mamíferos, as células germinativas primordiais (CGP) manifestam-se em estágios precoces do desenvolvimento, podendo ser detectadas pela primeira vez na metade da gastrulação. As CGP são células grandes, de citoplasma claro e núcleo grande e redondo, localizadas na parede do saco vitelino, perto do alantoide. Essas células possuem grande capacidade de proliferação e vão migrar desde o endoderma do intestino e o epitélio do saco vitelino, através do mesentério, até as cristas gonodais. Isso ocorre por volta do 26° dia da gestação no bovino. Sua migração realiza-se graças aos movimentos de translocação passiva e deslocamento ameboide ativo. Desconhece-se o mecanismo pelo qual estas células são dirigidas para as cristas gonodais, porém foram estudadas algumas moléculas que se expressam durante sua migração e que poderiam desempenhar um papel importante na diferenciação deste tipo celular. A fosfatase alcalina é uma enzima que tem sido usada como marcador de CGP para determinar a sua origem e migração. Num estudo recente, foi inserido um marcador fluorescente que se exprime unicamente nas células germinativas primordiais de embriões transgênicos, e utilizando este marcador e a fosfatase alcalina determinou-se a origem e o padrão de migração destas células. O primeiro sinal de diferenciação das células germinativas primordiais é a expressão de fosfatase alcalina, e esta apareceu pela primeira vez na parte mais posterior da linha primitiva. No sétimo dia de desenvolvimento no embrião do camundongo, o endoderma visceral (AF+) é substituído pelo endoderma definitivo (AF-) originado na parte anterior da linha primitiva. O fator de transcrição Oct-4 é expresso nas CGP de ambos os sexos, pelo que acredita-se estar envolvido na mantença a totipotêncialidade das células. O receptor tirosina quinase, cujo ligante é o fator de Steel, é outra das moléculas que expressam as CGP. Tem sido demonstrado que este receptor possui um papel muito importante na sobrevivência deste tipo celular. Existem outros fatores que promovem a sobrevivência e/ou proliferação de CGP in vitro. Em experiências realizadas com o fator de transformação beta I (TGFβ-I), observou-se que este tem um efeito negativo sobre a proliferação das CGP. Outra atividade que tem sido postulada a este fator é o de um agente quimioatraente que possivelmente possa direcionar a migração destas células para a gônada. a) Um formado pelas células germinativas primordiais (precursoras dos gametas masculinos ou femininos), rodeadas de células somáticas das quais posteriormente se derivarão as células de Sertoli no macho e as células da granulosa na fêmea. b) O tecido que formará o estroma da gônada: tecido conjuntivo, vasos sanguíneos e as células intersticiais com atividade esteroidogênica (células de Leydig no testículo e a teca interna do ovário). As células somáticas do primórdio gonodal originam-se do mesoderma. Inicialmente são de três tipos: mesenquimáticas, mesoteliais e endoteliais. As células mesenquimáticas e mesoteliais iniciam grande atividade proliferativa ao chegar as CGP. Observa-se então uma condensação de células de origem mesotelial e mesenquimatoso que forma um agregado compacto denominado "blastema gonodal". A partir deste primórdio embrionário, diferenciam-se dois tecidos gonodais: os cordões sexuais e o estroma. Os cordões sexuais são arranjos epiteliais que se encontram delimitados por uma folha basal, e dentro deles encontramos as CGP. Por sua vez, no estroma encontram-se células do tipo mesenquimático e vasos sanguíneos. Neste momento, as gônadas são indiferenciadas e bipotencialmente sexuais, sendo impossível diferenciar, morfologicamente, uma gônada masculina de uma feminina, mas no caso dos machos genéticos já existe uma diferenciação da gônada a nível molecular. Nesta fase já se encontram presentes as estruturas das quais se desenvolvem os dutos mesonéfricos ou de Wolff precursores do aparelho genital masculino e os dutos paramesonéfricos ou de Müller que darão origem ao aparelho reprodutor feminino. Há uma série de fatores envolvidos no desenvolvimento precoce da gônada, entre os quais o fator esteroidogênico I (SFI: Steroidogenic fator l), que é um membro da subfamília de receptores nucleares, receptores órfãos. Este fator de transcrição tem um local de ligação ao DNA composto por dois dedos-de-Zinc. O SFI foi identificado como um ativador de genes envolvidos na biossíntese de esteroides em diferentes células. O SFI está presente durante o desenvolvimento embrionário em regiões associadas com funções endócrinas como gônadas, adrenais, pituitárias e hipotálamos. Os animais homozigotos para o gene SFI defeituoso, necessitam de gônadas e adrenais e têm a função gonadotrófica alterada. Os ratos sem SFI carecem de gonadotrofos e têm um desenvolvimento anormal do núcleo ventro-medial do hipotálamo; em particular as gônadas deixam de se desenvolver entre os dias 11 a 15 e degeneram-se por apoptose. No entanto, a crista genital forma-se e é colonizada pelas células germinativas, o que indica que estas continuam a receber o sinal adequado para a sua migração. Portanto, o SFI não está envolvido no desenvolvimento precoce da gônada e do sistema urogenital, mas parece estar envolvido na manutenção do crescimento das células somáticas presentes na gônada indiferenciada. O gene associado ao tumor de Wilms (WTI: Wilm's tumor Associated) está envolvido no desenvolvimento da gônada e do rim. Durante o desenvolvimento embrionário, WTI se expressa em todo o mesoderma intermediário e posteriormente na gônada indiferenciada, bem como no rim em formação. WTI regula o sinal indutivo do mesênquima para o epitélio celômico dos mesonefros. Se este for o caso, então WTI é responsável pelo crescimento da crista genital ao dirigir a entrada do epitélio celômico. Dado que estas células darão origem às células de Sertoli, a carência de WTI pode causar o desenvolvimento de embriões XY como fêmeas simplesmente porque não se formam as células de Sertoli. Em geral, todos os genes importantes na diferenciação do mesoderma intermediário e do sistema urogenital intervêm no desenvolvimento da gônada precoce. 1.4 DIFERENCIAÇÃO GONODAL O desenvolvimento das gônadas e ductos genitais descritos até o momento, é o mesmo para ambos os sexos. Igualmente, os genes descritos, que estão envolvidos no desenvolvimento das gônadas, ductos genitais e migração das células germinativas, afetam igualmente os embriões com genótipo XX ou XY. A gônada primitiva consiste anatomicamente de uma medula (interna) e uma crosta (externa), e de acordo com o local onde ocorre a colonização das células germinativas, diferenciara em testículo ou um ovário, respectivamente. Nos mamíferos, a primeira manifestação estrutural de diferenciação sexual é detectada na gônada dos machos, onde as células germinativas estão localizadas na medula. A diferenciação do testículo inicia-se quando os cordões sexuais se separam do epitélio celômico como consequência dos arranjos produzidos por uma invasão do mesênquima e vasos sanguíneos que provoca a compactação dos cordões, agora denominados cordões testiculares. As células que rodeiam os cordões se achatam e formam as células mioides, que são responsáveis pela formação das membranas basais. As células do epitélio interno, ou seja, as células de Sertoli, têm duas funções principais: o suporte das CGP e a síntese da hormona antimulleriana, responsável pela regressão dos ductos de Müller e secretada durante o período de diferenciação sexual. As células do estroma que rodeiam os cordões testiculares diferenciam-se para formar vários tipos de células: células mioides, fibroblastos, endotélio e células de Leydig, que são as mais importantes pela sua atividade endócrina. Posteriormente, os cordões testiculares dão origem aos túbulos seminíferos, que contêm o epitélio que produzirá os espermatozoides ao chegar à puberdade. Na fêmea, durante os estágios iniciais de diferenciação gonodal, não se observam mudanças em relação à gônada indiferenciada, só pode-se observar um certo crescimento devido à proliferação de células somáticas e germinativas. As células germinativas iniciam um período de proliferação, que termina com o início da meiose. Iniciada a meiose, dá-se o processo de foliculogênese; neste momento os cordões epiteliais se fragmentam, de tal maneira que cada ovócito fica rodeado de células epiteliais cobertas por uma folha basal fina (figura 1). Para que a gônada primitiva se desenvolva em testículo é indispensável a presença do cromossoma Y, independentemente do número de cromossomas X que contenha o genoma de um indivíduo. O gene determinante do testículo encontra-se localizado no cromossoma Y, denominado sry em ratos e SRY em humanos. O gene sry se expressa durante o desenvolvimento embrionário na crista genital de embriões de camundongos. A expressão é detectável no dia 10,5, pouco depois do aparecimento das cristas genitais, atinge o seu máximo durante o dia 11,5 e mantém-se até pouco depois de ocorrerem os primeiros sinais morfológicos de diferenciação testicular no dia 12,5. Este padrão de expressão é compatível com a teoria de que sry atua induzindo a ativação dos genes (figura 2) que conduzem ao desenvolvimento testicular, sem que exista a necessidade da expressão contínua de sry para manter a diferenciação do testículo após o dia 12,5. Como mencionado anteriormente, a gônada primitiva é composta por vários tipos de células. No entanto, as células germinativas primordiais não são o local de expressão do sry, já que os embriões que necessitam de células germinativas mantêm a expressão de sry e desenvolvem o sexo gonodal normalmente. As células somáticas na gônada em desenvolvimento incluem também as células de suporte. Sabe-se que é nestas células que o sry é expresso para que se diferenciem em células de Sertoli, e a expressão transitória de sry indica que deve ativar a outros genes para a manutenção das células de Sertoli. Uma vez diferenciadas as células de Sertoli, elas se encarregarão da diferenciação do resto das células na gônada. -/- Figura 1: Representação da diferenciação dos órgãos genitais internos. Adaptado de BRONSON, 1989. Figura 2: Cascada de genes envolvidos na diferenciação sexual, adaptado de KOOPMAN, 1999. O fator sry é necessário para a diferenciação do testículo. Embora não se conheçam os genes que provavelmente regulam esse gene, estudos realizados em camundongos demonstram que este gene parece coordenar-se com certos genes autossômicos. Entre estes genes autossômicos, o sox9, que é produzido pelas células de Sertoli uma vez que são estimuladas por sry, de modo que sox9 é um dos genes relacionados estruturalmente com sry. O Sox9 funciona como um fator de transcrição, mas não se sabe se a proteína tem qualquer outra função estrutural; este gene exprime-se abundantemente nos condrócitos e está relacionado com defeitos do aparelho ósseo chamados displasia campomélica. Curiosamente, os pacientes XY com esta condição sofrem frequentemente de reversão do sexo. O Sox9 é um dos poucos genes, além do SRY, do qual as mutações demonstraram interferir com a determinação sexual masculina. No entanto, apenas 75% dos pacientes com anomalias esqueléticas de tipo displasia campomélica têm reversão sexual e não foram encontrados casos de reversão sexual devido a um defeito de Sox9 que não seja acompanhado de defeitos esqueléticos. Isso indica que o Sox9 é apenas um membro da rede de genes que são ativados para determinar a diferenciação sexual, enquanto a rota que rege a condrogênese é mais sensível a perturbações deste. O momento em que se detecta a expressão do gene Sox9 (11dpc em ratos) coincide com a máxima expressão de sry, o que poderia indicar a possibilidade de que sry regule positivamente a Sox9. De fato, na região do promotor de Sox9 há um local de união ao que potencialmente se pode unir o sry. A expressão de Sox9 durante a diferenciação sexual sugere um papel abaixo de sry na diferenciação das células de Sertoli. O cromossoma X também é importante na diferenciação gonodal. O gene DAX-I foi isolado do lócus DSS (Dosage sensitive sex reversal) do cromossoma X. DAX-I é parte da cascata de determinação sexual, mas não é necessário para a formação do testículo. DAX-I é um membro dos receptores nucleares conhecidos como receptores órfãos. Este gene demonstrou ser um poderoso repressor da transcrição de SFI e de vários genes. Os padrões de expressão de DAX-I são complementares daqueles de SFI, ambos expressos nas cristas genitais. Em resumo, dada a evidência exposta, desenvolveu-se a hipótese de que DAX-I é um antagonista de sry; esse antagonismo é dependente dos níveis relativos de DAX-I e sry e de um limiar que varia de espécie para espécie. A DAX-I foi classificada como o gene antitestículo. Na fêmea (cariótipo XX) é importante que ocorra a inativação de um dos cromossomas sexuais X para que se mantenha o equilíbrio genético ao igualar o conteúdo de DNA dos cromossomas. Esse cromossoma inativado constitui o chamado corpúsculo de Barr. No entanto, para que a meiose se realize, é necessário dos dois cromossomas X ativos nos ovócitos para assegurar a diferenciação ovárica e a fertilidade. 1.5 DIFERENCIAÇÃO DOS DUCTOS SEXUAIS O embrião possui, além das gônadas indiferenciadas, dois sistemas de ductos: os de potencialidade masculina denominam-se ductos de Wolff ou mesonéfricos, e os de potencialidade feminina se chamam ductos de Müller ou paramesonéfricos (figura 1). Se a diferenciação gonodal levou à formação de um testículo, a partir do ducto mesonéfrico ou de Wolff se desenvolverão os ductos eferentes, o epidídimo, os ductos deferentes e as vesículas seminais. As hormonas importantes no desenvolvimento do aparelho genital masculino são a testosterona, produzida pelas células de Leydig, e sua forma 5α reduzida, a 5α di-hidrotestosterona. Acredita-se que a testosterona é responsável pela virilização dos ductos de Wolff, e a di-hidrotestosterona dos órgãos genitais externos. No macho, os canais de Müller atrofiam-se devido à ação de uma hormona fetal de origem testicular denominada hormona inibidora das estruturas de Müller (HIM) ou hormona antimulleriana. Este processo começa assim que os cordões espermáticos se formam e se diferenciam as células de Sertoli. A existência de HIM foi proposta baseada em estudos realizados em bezerras freemartin, devido à existência de uma hormona responsável pela atresia dos ductos de Müller que na fêmea dá origem ao útero e aos ovidutos. Essa hormona provoca a involução do aparelho genital do bovino nas gestações gemelares nas quais os produtos de diferente sexo têm comunicação sanguínea por ter ocorrido a anastomose dos vasos de ambas as placentas (figura 3). A HIM é uma glicoproteína pertencente à subfamília de TGFβ, é expressa pelas células que darão origem às células de Sertoli e é um dos primeiros marcadores de diferenciação nestas células. A HIM é secretada na vida adulta pelas células de Sertoli no testículo e por células da granulosa no ovário. No rato a HIM é expressa-se no 12° dia em um teste padrão que segue muito de perto o aumento na expressão de sry. No macho, esta secreção de HIM continua durante a vida fetal e adulta, contudo os níveis de HIM declinam na puberdade devido a um aumento na secreção de testosterona. Vários fatores intervêm na regulação do gene de HIM, incluindo os acima descritos SFI e Sox9. O gene HIM contém segmentos de DNA que são conservados em várias espécies de vertebrados. Existe um nexo de ligação para SFI, que ativa a transcrição de HIM. A mutação no local de ligação de SFI resulta em reversão do sexo em indivíduos XY incluindo genitais femininos normais, presença de um útero formado enfatizando a importância de SFI na determinação sexual e na expressão de HIM. Embora SFI seja um bom candidato como regulador de HIM, é expresso em outras células, como as de Leydig e adrenais, que não expressam HIM. Em contrapartida, Sox9 é expresso unicamente nas células de Sertoli que são as produtoras de HIM. O gene HIM também tem um nexo de ligação para Sox9. Além disso, Sox9 pode atuar sinergicamente com SFI para promover a secreção de HIM. Ao contrário destes dois fatores de transcrição, DAX-I antagoniza a ação de Sox9 e provavelmente SFI sobre o promotor de HIM. Assim, para que as células de Sertoli secretem HIM, a transcrição de DAX-I deve diminuir. Figura 3: Representação da diferenciação dos órgãos genitais externos. Adaptado de BRONSON, 1989. Os ductos de Wolff tornam-se o sistema de ejaculação do macho. A porção mais próxima dos testículos dá origem ao epidídimo, a parte central ao ducto deferente e a porção mais distal às vesículas seminais. A próstata e a parte membranosa da uretra do macho desenvolvem-se a partir da porção pélvica do seio urogenital. A virilização e diferenciação dos ductos de Wolff dependem da produção de testosterona pelo testículo. Quanto aos órgãos genitais externos do macho, o tubérculo genital é ampliado e as dobras uretrais se fundem para formar a uretra peniana. A fusão das dobras uretrais aproxima os tubérculos genitais para formar o escroto (figura 4). Figura 4: Diferenciação do aparelho genital da fêmea e do macho. Adaptado de KOOPMAN, 1989. A diferenciação dos órgãos genitais da fêmea ocorre de forma passiva, já que a ausência de testículos e por isso da hormona inibidora dos ductos de Müller (HIM), assim como dos andrógenos virilizantes, favorece o desenvolvimento dos ductos de Müller, enquanto os de Wolff sofrem atrofia. A porção cefálica dos ductos de Müller dá origem aos ovidutos, que na sua terminação caudal se fundem com o útero. O contato dos ductos de Müller com o seio urogenital induz uma intensa proliferação celular que resulta na formação da área uterovaginal localizado entre o seio urogenital e os ductos de Müller. As células do prato uterovaginal proliferam e aumentam a distância entre as duas estruturas criando o espaço que formará a vagina quando o prato é canalizado e forma um lúmen. Em contraste com o que ocorre no macho, na fêmea a maior parte do seio urogenital se mantém exposta na superfície da abertura onde desembocam a vagina e a uretra. O tubérculo urogenital da fêmea tem um crescimento limitado e forma o clitóris. A sequência de passos da diferenciação sexual do aparelho genital é resumida na tabela 1. Tabela 1: Destino em desenvolvimento dos rudimentos sexuais dos fetos macho e fêmea dos mamíferos -/- Rudimento sexual Macho Fêmea Gônada Testículo Ovário Ductos de Müller (Paramesonéfricos) Vestígios Útero, parte da vagina, ovidutos Ductos de Wolff (Mesonéfricos) Ductos eferentes deferentes, epidídimo, vesículas seminais Vestígios Seio urogenital Uretra, próstata, glândulas bulbouretrais Parte da vagina, uretra, vestíbulo, glândulas vestibulares Tubérculo genital Pênis Clitóris Pregas vestibulares Escroto Lábios vulvares Fonte: HAFEZ, 2004. 1.6 DIFERENCIAÇÃO SEXUAL DO HIPOTÁLAMO Os processos de diferenciação sexual não se limitam apenas às células somáticas do organismo do feto, mas incluem também os centros nervosos superiores do cérebro. Assim, da mesma maneira que a gônada e os ductos sexuais se desenvolvem para o tipo feminino ou masculino, propôs-se que o cérebro pode ser "masculinizado" ou permanecer "Feminizado". A diferenciação do hipotálamo vai depender do ambiente esteroidal do neonato e ocorre na fase perinatal. Estes eventos serão de grande transcendência na vida reprodutiva do indivíduo. Tanto a fêmea como o macho nascem com a capacidade de secreção de gonadotropinas de acordo com um padrão cíclico; contudo, no macho, a exposição do hipotálamo à ação dos andrógenos testiculares durante os primeiros dias da vida extrauterina provoca a masculinização, com o qual o hipotálamo do macho é programado para que a secreção de gonadotropinas se realize a um ritmo relativamente constante por parte da hipófise (secreção tônica). Na fêmea, tanto a secreção tônica como a cíclica se conservam. No entanto, observou-se que a injeção de testosterona ou o transplante de testículo na rata fêmea durante os primeiros dias de vida, suprime a sua futura atividade estral (secreção cíclica). Por outro lado, se os ovários forem transplantados para o rato macho normal castrado na idade adulta, o animal não desenvolve qualquer atividade cíclica, mas se os machos transplantados forem castrados ao nascer, o ovário é capaz de efetuar mudanças cíclicas e ovulações. Isto foi demonstrado em roedores, mas não em animais domésticos ou na espécie humana. Portanto, o padrão de secreção de gonadotropinas, seja cíclico ou tônico, não depende da hipófise, mas do hipotálamo e sua correta diferenciação. 1.7 CONCLUSÕES A maioria dos conhecimentos no campo da biologia do desenvolvimento e, muito especificamente, dos processos de diferenciação sexual têm sido originados de estudos relacionados com desordens congênitas, que na sua maioria devem-se a defeitos de genes específicos. A análise detalhada destas desordens permitiu entender alguns mecanismos endócrinos, moleculares e genéticos envolvidos na diferenciação sexual. A identificação do gene sry como determinante do testículo foi uma contribuição crucial e abriu as portas à compreensão dos mecanismos moleculares e celulares relacionados com o desenvolvimento do testículo. Se este gene não estiver presente, é criado um programa genético alternativo para levar a cabo a diferenciação gonodal para o ovário. Finalmente, devemos ter presente que é necessária uma correlação entre mudanças morfológicas e expressão de genes durante o desenvolvimento para entender os mecanismos relacionados com a diferenciação. -/- Apoio -/- Realização -/- REFERÊNCIAS BIBLIOGRÁFICAS ANDERSON, Robert et al. The onset of germ cell migration in the mouse embryo. Mechanisms of development, v. 91, n. 1-2, p. 61-68, 2000. AUSTIN, Colin Russell; SHORT, R. V. Reproduction in Mammals: Volume 1, Germ Cells and Fertilization. Londres: Cambridge University Press, 1972. BRONSON, Franklin H. Mammalian reproductive biology. Chicago: University of Chicago Press, 1989. BUEHR, Mia. The primordial germ cells of mammals: some current perspectives. Experimental cell research, v. 232, n. 2, p. 194-207, 1997. BYSKOV, Anne G. Differentiation of mammalian embryonic gonad. Physiological reviews, v. 66, n. 1, p. 71-117, 1986. CAPEL, Blanche et al. Migration of mesonephric cells into the mammalian gonad depends on Sry. Mechanisms of development, v. 84, n. 1-2, p. 127-131, 1999. CAPEL, Blanche. The battle of the sexes. Mechanisms of development, v. 92, n. 1, p. 89-103, 2000. DERIVAUX, Jules; BARNABÉ, Renato Campanarut. Reprodução dos animais domésticos. Zaragoza: Acribia, 1980. DOMENICE, Sorahia et al. Aspectos moleculares da determinação e diferenciação sexual. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 46, n. 4, p. 433-443, 2002. DONAHOE, Patricia K. et al. Mullerian inhibiting substance activity in bovine fetal, newborn and prepubertal testes. Biology of reproduction, v. 16, n. 2, p. 238-243, 1977. HAFEZ, Elsayed Saad Eldin; HAFEZ, B. Reprodução animal. São Paulo: Manole, 2004. HANLEY, Neil A. et al. Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Molecular and cellular endocrinology, v. 163, n. 1-2, p. 27-32, 2000. HIORT, Olaf; PAUL-MARTIN, H. The molecular basis of male sexual differentiation. European journal of endocrinology, v. 142, n. 2, p. 101-110, 2000. HOLY, Lubos; MARTÍNEZ JÚSTIZ, G. Colab. Biología de la reproducción bovina. Havana: Revolucionária, 1975. JOSSO, Nathalie et al. The role of anti-Müllerian hormone in gonadal development. Molecular and cellular endocrinology, v. 145, n. 1-2, p. 3-7, 1998. JOST, Alfred et al. Studies on sex differentiation in mammals. In: Proceedings of the 1972 Laurentian Hormone Conference. Londres: Academic Press, 1973. p. 1-41. KNOBIL, Ernst. Knobil and Neill's physiology of reproduction. EUA: Gulf Professional Publishing, 2006. KOFMAN ALFARO, S.; MERCHANT LARIOS, H.; PEREZ PALACIOS, G. Diferenciacion sexual. I. Bases biologicas del dimorfismo sexual. Rev. invest. clín, p. 349-59, 1982. KOOPMAN, Peter. Sry and Sox9: mammalian testis-determining genes. Cellular and Molecular Life Sciences CMLS, v. 55, n. 6-7, p. 839-856, 1999. MCDONALD, L. E. Veterinary endocrinology. Lea & Febiger, Philadelphia, Pa, 1969. MEIZEL, S.; JOHNSON, M. H. Development in mammals. MH Johnson, Ed, v. 3, p. 1-64, 1978. MELLO, Maricilda Palandi de; ASSUMPÇÃO, Juliana de G.; HACKEL, Christine. Genes envolvidos na determinação e diferenciação do sexo. Arquivos Brasileiros de Endocrinologia & Metabologia, v. 49, n. 1, p. 14-25, 2005. -/- REFERÊNCIAS BIBLIOGRÁFICAS MERCHANT-LARIOS, H. Ovarian differentiation. The Vertebrate Ovary, p. 47-81, 1978. MIES FILHO, Antonio. Reprodução dos animais. Porto Alegre: Sulina, 1987. NEF, Serge; PARADA, Luis F. Hormones in male sexual development. Genes & Development, v. 14, n. 24, p. 3075-3086, 2000. PARKER, Keith L.; SCHEDL, Andreas; SCHIMMER, Bernard P. Gene interactions in gonadal development. Annual review of physiology, v. 61, n. 1, p. 417-433, 1999. SWAIN, Amanda; LOVELL-BADGE, Robin. Mammalian sex determination: a molecular drama. Genes & development, v. 13, n. 7, p. 755-767, 1999. WILHELM, Dagmar; PALMER, Stephen; KOOPMAN, Peter. Sex determination and gonadal development in mammals. Physiological reviews, v. 87, n. 1, p. 1-28, 2007. WILSON, Jean D.; GRIFFIN, James E.; GEORGE, Fredrick W. Sexual differentiation: early hormone synthesis and action. Biology of reproduction, v. 22, n. 1, p. 9-17, 1980. -/- Emanuel Isaque Cordeiro da Silva Belo Jardim, 07 de Maio de 2020. (shrink)

COTENT -/- (April 2019) Why so many people (from so many countries/domains/on so many topics) have already plagiarized my ideas? (Gabriel Vacariu) -/- Some preliminary comments Introduction: The EDWs perspective in my article from 2005 and my book from 2008 -/- I. PHYSICS, COGNITIVE NEUROSCIENCE, PHILOSOPHY (‘REBORN DINOSAURS’) • (2016) Sean Carroll (California Institute of Technology, USA) • (2016) Frank Wilczek (Nobel Prize in Physics) • (2017-2019 - NEW March 2019) Carlo Rovelli in three books (2015, 2017) to my ideas (...) (2002-2008) + commentary February 2018! • (2016) Kastner + (2017) R. E. Kastner, Stuart Kauffman, Michael Epperson • (2017) Lee Smolin (2017) • (May 2018) ‘Thus spoke Zarathustra!’ - A fairy-tale with Eugen Ionesco and the Idiot about Nothingness -/- II. PHYSICS • (2011) Radu Ionicioiu (Physics, University of Bucharest, Romania) and Daniel R. Terno’s ideas (Physics, Macquarie University, Sydney • (2013) Côté B. Gilbert (Oontario, Canada) • (2015) Pikovski Igor, Zych Magdalena, Costa Fabio, and Brukner Časlav • (2015) Elisabetta Caffau (Center for Astronomy at the University of Heidelberg and the Paris Observatory) • (2015) Wolfram Schommers • (2015) Some astrophysicists • (2016) Dylan H. Mahler, Lee Rozema, Kent Fisher, Lydia Vermeyden, Kevin J. Resch, Howard M. Wiseman, and Aephraim Steinberg • (2016) Bill Poirier • (2016 or 2017) Adam Frank • (2017, 2017) Sebastian de Haro • (2017) Laura Condiotto • (2016) Hugo F. Alrøe and Egon Noe • (2017) Federico Zalamea • (2018) Unbelievable similarities between Peter J. Lewis’s ideas (2018) and my ideas (2002-2008) • (2018) Timothy Hollowood, ‘Classical from Quantum’ • (2018) Mario Hubert and Davide Romano, ‘The Wave-Function as a Multi-Field’ -/- III. COGNITIVE NEUROSCIENCE AND PHILOSOPHY OF MIND • (2011-2014) Did Georg Northoff (Psychoanalysis, Institute of Mental Health) plagiarize my ideas (2002-2008)? • (2011) Kalina Diego Cosmelli, Legrand Dorothée and Thompson Evan’s ideas (USA) • (2015) David Ludwig (Philosophy, University of Amsterdam) • (2016) Neil D. Theise (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA) and Kafatos C. Menas • David Bourget (2018) (or University of Western Ontario) + Chalmers • (2016) Dan Siegel (Mindsight Institute, USA) -/- IV. Philosophy (of science) • (2010) Alexey Alyushin (Moscow, Russia) • (2013 + 2017) Markus Gabriel (Bonn University) • (2013) Andrew Newman’s ideas (University of Nebraska, at Omaha, USA) • (2016) Tahko E. Tuomas (University of Helsinki, Finland) + Tahko E. Tuomas • (2017) Jani Hakkarainen (University of Tampere, Finland) + (2017) Markku Keinänen, Antti Keskinen & Jani Hakkarainen • (2017) Dean Rickles (HPS, Univ. of Sydney) • (2017) Did Dirk K. F. Meijer and Hans J. H. Geesink (University of Groningen, Netherlands) • (2018) Jason Winning’s ideas (2018) • (2018) David Mark Kovacs (Lecturer of philosophy at Tel Aviv University) -/- July 2018 • Oreste M. Fiocco • Baptiste Le Bihan (University of Geneva, forthcoming) • Antonella Mallozzi (The Graduate Center – CUNY, forthcoming in Synthese, penultimate draft) • Erik C. Banks (Wright State University, 2014) • Sami Pihlström (2009) • Katherin Koslicki’s ideas (2008) The Structure of Objects, Oxford University Press) and my ideas (2002-2005-2006) -/- November 2018 • Maurizio Ferraris (2014/2012) Manifesto of New Realism • Graham Harman (2017) : Object-Oriented Ontology: A New Theory of Everything (Penguin Books) -/- January 2019 • Philip Ball (2018) • Gerhard Grössing • Anne Sophie Meincke (November 2018) • Baptiste Le Bihana (University of Geneva) and James Read (Oxford Univ.) • Baptiste Le Bihan (University of Geneva) • Alexander Alexandrovich Antonov (2016) (Research Center of Information Technologies “TELAN Electronics”, Kiev, Ukraine): -/- February 2019 • James Barham (2019) • Giorgio Lando (2017) • (2018) Albrecht von M¨uller • Elias Zafiris • (2019) Flaminia Giacomini, Esteban Castro-Ruiz, & Časlav • (2019) Valia Allori, OUP (2019) • (2018) Paulo De Jesus Phenom Cogn Sci • (2016) TIMOTHY MORTON, For a Logic of Future Coexistence • (2017) Andrew Cooper, Two directions for teleology: naturalism and idealism, Synthese -/- March 2019 • (2019) Massimiliano Proietti,1 Alexander Pickston,1 Francesco Graffitti,1 Peter Barrow,1 Dmytro Kundys,1 Cyril Branciard,2 Martin Ringbauer,1, 3 and Alessandro Fedrizzi1: (2019) • (2015) Cˇaslav Brukner On the quantum measurement problem, at arXiv:1507.05255v1 [quant-ph] 19 Jul 2015 • (2015) Mateus Araújo, Cyril Branciard, Fabio Costa, Adrien Feix, Christina Giarmatzi, Časlav Brukner, Witnessing causal nonseparability, • (2008 + 2013) Giulio Chiribella,∗ Giacomo Mauro D’Ariano,† and Paolo Perinotti‡ QUIT Group, Dipartimento di Fisica “A. Volta” and INFM, via Bassi 6, 27100 Pavia, Italy§ (Dated: October 22, 2018): Transforming quantum operations: quantum supermaps arXiv:0804.0180v2 [quant-ph] (22 Oct 2008) + Giulio Chiribella,1, ∗ Giacomo Mauro D’Ariano,2, † Paolo Perinotti,2, ‡ and Benoit Valiron3, § (2013), Quantum computations without definite causal structure, at • (2013) Ognyan Oreshkov1;2, Fabio Costa1, Cˇ aslav Brukner1;3, Quantum correlations with no causal order, • (2018) Marcus Schmieke, Kränzlin, 17 July 2018 These articles are in this book: Reality and its Structure - Essays in Fundamentality, Ricki Bliss and Graham Priest (2018), -/- Gabriel Oak Rabin (2018) Grounding Orthodoxy and the Layered Conception Daniel Nolan (2018) Cosmic Loops Naomi Thompson (2018) Metaphysical Interdependence, Epistemic Coherentism, and Tuomas E. Tahko (2018) Holistic Explanation Fundamentality and Ontological Minimality Matteo Morganti (2018) The Structure of Physical Reality Beyond Foundationalism Nathan Wildman (2018) On Shaky Ground? Exploring the Contingent Fundamentality Thesis -/- April 2019 (2015) M. Ringbauer1;2, B. Du_us1;2, C. Branciard1;3, E. G. Cavalcanti4, A. G. White1;2 & A. Fedrizzi: “Measurements on the reality of the wavefunction” -/- June 2019 Timothy Morton (2013), Realist Magic: Objects, Ontology, Causality (2013) Open Humanities Press Ian Bogost, Alien Phenomenology or, What It’s Like to Be a Thing (Minneapolis: University of Minnesota Press, 2012), 1–34 “Ian Bogost thinks objects as units”: Unit Operations: An Approach to Videogame Criticism (Cambridge: MIT Press, 2008) in Timothy Morton 2013, Realist Magic: Objects, Ontology, Causality (2013) OPEN HUMANITIES PRESS (I have not read Bogost yet, but in Morton’s book, I found UNBELIEVABLE similarity between Bogost’s main ideas and my EDWs ideas!!) -/- [Obviously, there are other “specialists” that published UNBELIEVABLE similar ideas to my ideas but I have not discovered them yet…] -/- . (shrink)

COTENT -/- (April 2019) Why so many people (from so many countries/domains/on so many topics) have already plagiarized my ideas? (Gabriel Vacariu) -/- Some preliminary comments Introduction: The EDWs perspective in my article from 2005 and my book from 2008 -/- I. PHYSICS, COGNITIVE NEUROSCIENCE, PHILOSOPHY (‘REBORN DINOSAURS’) • (2016) Sean Carroll (California Institute of Technology, USA) • (2016) Frank Wilczek (Nobel Prize in Physics) • (2017-2019 - NEW March 2019) Carlo Rovelli in three books (2015, 2017) to my ideas (...) (2002-2008) + commentary February 2018! • (2016) Kastner + (2017) R. E. Kastner, Stuart Kauffman, Michael Epperson • (2017) Lee Smolin (2017) • (May 2018) ‘Thus spoke Zarathustra!’ - A fairy-tale with Eugen Ionesco and the Idiot about Nothingness -/- II. PHYSICS • (2011) Radu Ionicioiu (Physics, University of Bucharest, Romania) and Daniel R. Terno’s ideas (Physics, Macquarie University, Sydney • (2013) Côté B. Gilbert (Oontario, Canada) • (2015) Pikovski Igor, Zych Magdalena, Costa Fabio, and Brukner Časlav • (2015) Elisabetta Caffau (Center for Astronomy at the University of Heidelberg and the Paris Observatory) • (2015) Wolfram Schommers • (2015) Some astrophysicists • (2016) Dylan H. Mahler, Lee Rozema, Kent Fisher, Lydia Vermeyden, Kevin J. Resch, Howard M. Wiseman, and Aephraim Steinberg • (2016) Bill Poirier • (2016 or 2017) Adam Frank • (2017, 2017) Sebastian de Haro • (2017) Laura Condiotto • (2016) Hugo F. Alrøe and Egon Noe • (2017) Federico Zalamea • (2018) Unbelievable similarities between Peter J. Lewis’s ideas (2018) and my ideas (2002-2008) • (2018) Timothy Hollowood, ‘Classical from Quantum’ • (2018) Mario Hubert and Davide Romano, ‘The Wave-Function as a Multi-Field’ -/- III. COGNITIVE NEUROSCIENCE AND PHILOSOPHY OF MIND • (2011-2014) Did Georg Northoff (Psychoanalysis, Institute of Mental Health) plagiarize my ideas (2002-2008)? • (2011) Kalina Diego Cosmelli, Legrand Dorothée and Thompson Evan’s ideas (USA) • (2015) David Ludwig (Philosophy, University of Amsterdam) • (2016) Neil D. Theise (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA) and Kafatos C. Menas • David Bourget (2018) (or University of Western Ontario) + Chalmers • (2016) Dan Siegel (Mindsight Institute, USA) -/- IV. Philosophy (of science) • (2010) Alexey Alyushin (Moscow, Russia) • (2013 + 2017) Markus Gabriel (Bonn University) • (2013) Andrew Newman’s ideas (University of Nebraska, at Omaha, USA) • (2016) Tahko E. Tuomas (University of Helsinki, Finland) + Tahko E. Tuomas • (2017) Jani Hakkarainen (University of Tampere, Finland) + (2017) Markku Keinänen, Antti Keskinen & Jani Hakkarainen • (2017) Dean Rickles (HPS, Univ. of Sydney) • (2017) Did Dirk K. F. Meijer and Hans J. H. Geesink (University of Groningen, Netherlands) • (2018) Jason Winning’s ideas (2018) • (2018) David Mark Kovacs (Lecturer of philosophy at Tel Aviv University) -/- July 2018 • Oreste M. Fiocco • Baptiste Le Bihan (University of Geneva, forthcoming) • Antonella Mallozzi (The Graduate Center – CUNY, forthcoming in Synthese, penultimate draft) • Erik C. Banks (Wright State University, 2014) • Sami Pihlström (2009) • Katherin Koslicki’s ideas (2008) The Structure of Objects, Oxford University Press) and my ideas (2002-2005-2006) -/- November 2018 • Maurizio Ferraris (2014/2012) Manifesto of New Realism • Graham Harman (2017) : Object-Oriented Ontology: A New Theory of Everything (Penguin Books) -/- January 2019 • Philip Ball (2018) • Gerhard Grössing • Anne Sophie Meincke (November 2018) • Baptiste Le Bihana (University of Geneva) and James Read (Oxford Univ.) • Baptiste Le Bihan (University of Geneva) • Alexander Alexandrovich Antonov (2016) (Research Center of Information Technologies “TELAN Electronics”, Kiev, Ukraine): -/- February 2019 • James Barham (2019) • Giorgio Lando (2017) • (2018) Albrecht von M¨uller • Elias Zafiris • (2019) Flaminia Giacomini, Esteban Castro-Ruiz, & Časlav • (2019) Valia Allori, OUP (2019) • (2018) Paulo De Jesus Phenom Cogn Sci • (2016) TIMOTHY MORTON, For a Logic of Future Coexistence • (2017) Andrew Cooper, Two directions for teleology: naturalism and idealism, Synthese -/- March 2019 • (2019) Massimiliano Proietti,1 Alexander Pickston,1 Francesco Graffitti,1 Peter Barrow,1 Dmytro Kundys,1 Cyril Branciard,2 Martin Ringbauer,1, 3 and Alessandro Fedrizzi1: (2019) • (2015) Cˇaslav Brukner On the quantum measurement problem, at arXiv:1507.05255v1 [quant-ph] 19 Jul 2015 • (2015) Mateus Araújo, Cyril Branciard, Fabio Costa, Adrien Feix, Christina Giarmatzi, Časlav Brukner, Witnessing causal nonseparability, • (2008 + 2013) Giulio Chiribella,∗ Giacomo Mauro D’Ariano,† and Paolo Perinotti‡ QUIT Group, Dipartimento di Fisica “A. Volta” and INFM, via Bassi 6, 27100 Pavia, Italy§ (Dated: October 22, 2018): Transforming quantum operations: quantum supermaps arXiv:0804.0180v2 [quant-ph] (22 Oct 2008) + Giulio Chiribella,1, ∗ Giacomo Mauro D’Ariano,2, † Paolo Perinotti,2, ‡ and Benoit Valiron3, § (2013), Quantum computations without definite causal structure, at • (2013) Ognyan Oreshkov1;2, Fabio Costa1, Cˇ aslav Brukner1;3, Quantum correlations with no causal order, • (2018) Marcus Schmieke, Kränzlin, 17 July 2018 These articles are in this book: Reality and its Structure - Essays in Fundamentality, Ricki Bliss and Graham Priest (2018), -/- Gabriel Oak Rabin (2018) Grounding Orthodoxy and the Layered Conception Daniel Nolan (2018) Cosmic Loops Naomi Thompson (2018) Metaphysical Interdependence, Epistemic Coherentism, and Tuomas E. Tahko (2018) Holistic Explanation Fundamentality and Ontological Minimality Matteo Morganti (2018) The Structure of Physical Reality Beyond Foundationalism Nathan Wildman (2018) On Shaky Ground? Exploring the Contingent Fundamentality Thesis -/- April 2019 (2015) M. Ringbauer1;2, B. Du_us1;2, C. Branciard1;3, E. G. Cavalcanti4, A. G. White1;2 & A. Fedrizzi: “Measurements on the reality of the wavefunction” -/- June 2019 Timothy Morton (2013), Realist Magic: Objects, Ontology, Causality (2013) Open Humanities Press Ian Bogost, Alien Phenomenology or, What It’s Like to Be a Thing (Minneapolis: University of Minnesota Press, 2012), 1–34 “Ian Bogost thinks objects as units”: Unit Operations: An Approach to Videogame Criticism (Cambridge: MIT Press, 2008) in Timothy Morton 2013, Realist Magic: Objects, Ontology, Causality (2013) OPEN HUMANITIES PRESS (I have not read Bogost yet, but in Morton’s book, I found UNBELIEVABLE similarity between Bogost’s main ideas and my EDWs ideas!!) -/- [Obviously, there are other “specialists” that published UNBELIEVABLE similar ideas to my ideas but I have not discovered them yet…] -/- . (shrink)

Für ein Gespräch über die Themen Political Correctness, Identitätspolitik, Streitkultur und die Rolle der politischen Bildung kamen im Juli 2021 Saba-Nur Cheema von der Bildungsstätte Anne Frank und Dr. Karsten Schubert von der Universität Freiburg in einem Zoom-Raum zusammen. Die Fragen stellten Prof. Dr. Beate Rosenzweig und Petra Barz, beide Mitglieder im Redaktionsbeirat der "Außerschulischen Bildung". Der folgende Text ist eine bearbeitete und gekürzte Fassung des Gesprächs.

COTENT -/- (second April 2019) Why so many people (from so many countries/domains/on so many topics) have already plagiarized my ideas? (Gabriel Vacariu) -/- Some preliminary comments Introduction: The EDWs perspective in my article from 2005 and my book from 2008 -/- I. PHYSICS, COGNITIVE NEUROSCIENCE, PHILOSOPHY (‘REBORN DINOSAURS’ ) • (2016) Did Sean Carroll’s ideas (California Institute of Technology, USA) plagiarize my ideas (2002-2010) (within the EDWs framework)? • (2016) Frank Wilczek’s ideas (Nobel Prize in Physics) (Philosophy of Mind (...) and Quantum Mechanics) • (2017-2019 - NEW March 2019) Carlo Rovelli’s ideas (Italy) in three books (2015, 2017) to my ideas (2002-2008) + commentary February 2018! • (2016) Kastner + (2017) R. E. Kastner, Stuart Kauffman, Michael Epperson • (2017) A trick: Lee Smolin’s ideas (2017) and my ideas (2002-2008) • (May 2018) ‘Thus spoke Zarathustra!’ - A fairy-tale with Eugen Ionesco and the Idiot about Nothingness -/- II. PHYSICS • (2011) Radu Ionicioiu (Physics, University of Bucharest, Romania) and Daniel R. Terno (Physics, Macquarie University, Sydney, Australia) • (2013) Côté B. Gilbert (Oontario, Canada) • (2015) Pikovski Igor, Zych Magdalena, Costa Fabio, and Brukner Časlav’s ideas and my ideas (2006-2008) (Quantum Mechanics) • (2015) Elisabetta Caffau’s ideas (Center for Astronomy at the University of Heidelberg and the Paris Observatory) and my ideas (2011, 2014) • (2015) Did Wolfram Schommers (University of Texas at Arlington, USA & Karlsruhe Institute of Technology, Germany) (Physics) • (2015) "Dark Matter May be 'Another Dimension' - Or Even a Major Galactic Transport System" January 22, 2015 • (2016) Dylan H. Mahler, Lee Rozema, Kent Fisher, Lydia Vermeyden, Kevin J. Resch, Howard M. Wiseman, and Aephraim Steinberg’s ideas (USA) • (2016) Bill Poirier’s ‘Many Interacting Worlds’ (Quantum Mechanics) • (2016 or Adam Frank’s ideas (University of Rochester in New York , USA) • (2017, 2017) Did Sebastian de Haro (HPS, Cambridge, UK) plagiarize my ideas (2002-2008) • (2017) Laura Condiotto’s ideas and my ideas (2002-2008) • (2016) Hugo F. Alrøe and Egon Noe’s (Department of Agroecology, Aarhus University, Denmark) ideas (USA) • (2017) Federico Zalamea’s ideas and my ideas • (2018) Peter J. Lewis’s ideas (2018) and my ideas (2002-2008) • (2018) Timothy Hollowood, ‘Classical from Quantum’, [arXiv:1803.04700v1 [quant-ph] 13 March 2018] • (2018) Mario Hubert and Davide Romano, ‘The Wave-Function as a Multi-Field’ -/- III. COGNITIVE NEUROSCIENCE AND PHILOSOPHY OF MIND • (2011-2014) Did Georg Northoff (Psychoanalysis, Institute of Mental Health) plagiarize my ideas (2002-2008)? • (2011) Kalina Diego Cosmelli, Legrand Dorothée and Thompson Evan’s ideas (USA) and my ideas (Cognitive Neuroscience) • (2015) Did David Ludwig (Philosophy, University of Amsterdam) plagiarize many of my ideas? (Philosophy (of Mind) • (2016) Neil D. Theise (Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, USA) and Kafatos C. Menas (Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, USA) • David Bourget (2018) (Director, Centre for Digital Philosophy, Western University (or University of Western Ontario) + Chalmers • (2016) Dan Siegel’s ideas (Mindsight Institute, USA) -/- IV. Philosophy (of science) • (2010) Alexey Alyushin (Moscow, Russia) • (2013 + 2017) Did Markus Gabriel (Bonn University) • (2013) Andrew Newman’s ideas (University of Nebraska, at Omaha, USA) • (2016) Did Tahko E. Tuomas (University of Helsinki, Finland) plagiarize my ideas? + Tahko E. Tuomas (‘The Epistemology of Essence’) • (2017) Jani Hakkarainen (University of Tampere, Finland) + (2017) Markku Keinänen, Antti Keskinen & Jani Hakkarainen • (2017) Dean Rickles’s ideas (HPS, Univ. of Sydney) • (2017) Did Dirk K. F. Meijer and Hans J. H. Geesink (University of Groningen, Netherlands • (2018) Jason Winning’s ideas (2018) • (2018) David Mark Kovacs (Lecturer of philosophy at Tel Aviv University) -/- Conclusion Bibliography -/- July 2018 • Oreste M. Fiocco • Baptiste Le Bihan (University of Geneva, forthcoming) • Antonella Mallozzi (The Graduate Center – CUNY, forthcoming in Synthese, penultimate draft) • Erik C. Banks (Wright State University, 2014) • Sami Pihlström (2009) • Katherin Koslicki’s ideas (2008) -/- November 2018 • Maurizio Ferraris (2014/2012) Manifesto of New Realism • Graham Harman (2017) : Object-Oriented Ontology: -/- January 2019 • Philip Ball (2018): “Why everything you thought you knew about quantum physics is different” • Gerhard Grössing “Vacuum landscaping: cause of nonlocal influences without signaling” • Anne Sophie Meincke (November 2018) The Disappearance of Change (IJPS) • Baptiste Le Bihana (University of Geneva) and James Read (Oxford Univ.) “Duality and Ontology” • Baptiste Le Bihan (University of Geneva): “Space Emergence in Contemporary Physics: • Alexander Alexandrovich Antonov (2016) -/- February 2019 • James Barham (2019): “The Reality of Purpose and the Reform of Naturalism” • Giorgio Lando (2017) Mereology - A Philosophical Introduction, Bloomsbury Academic • (2018) Albrecht von M¨uller • Elias Zafiris, Concept and Formalization of Constellatory Self-Unfolding • (2019) Flaminia Giacomini, Esteban Castro-Ruiz, & Časlav Brukner • (2019) Valia Allori, “Scientific Realism without the Wave-Function: An Example of Naturalized Quantum Metaphysics” • (2018) Paulo De Jesus “Thinking through enactive agency: • (2016) TIMOTHY MORTON, For a Logic of Future Coexistence, (Columbia University Press) • (2017) Andrew Cooper, Two directions for teleology: -/- March 2019 • (2019) Massimiliano Proietti,1 Alexander Pickston,1 Francesco Graffitti,1 Peter Barrow,1 Dmytro Kundys,1 Cyril Branciard,2 Martin Ringbauer,1, 3 and Alessandro Fedrizzi1: (2019) “Experimental rejection of observer-independence in the quantum world” • (2015) Cˇaslav Brukner On the quantum measurement problem, • (2015) Mateus Araújo, Cyril Branciard, Fabio Costa, Adrien Feix, Christina Giarmatzi, Časlav Brukner, Witnessing causal nonseparability, • (2008 + 2013) Giulio Chiribella,∗ Giacomo Mauro D’Ariano,† and Paolo Perinotti‡ QUIT Group, Dipartimento di Fisica “A. Volta” and INFM, via Bassi 6, 27100 Pavia, Italy§ (Dated: October 22, 2018): Transforming quantum operations: quantum supermaps (22 Oct 2008) + Giulio Chiribella,1, ∗ Giacomo Mauro D’Ariano,2, † Paolo Perinotti,2, ‡ and Benoit Valiron3, § (2013), Quantum computations without definite causal structure, • (2013) Ognyan Oreshkov1;2, Fabio Costa1, Cˇ aslav Brukner1;3, Quantum correlations • (2018) Marcus Schmieke, Kränzlin, 17 July 2018, “Orthogonal Complementarity -/- April 2019 These articles are in this book: Reality and its Structure - Essays in Fundamentality, Ricki Bliss and Graham Priest (2018), Oxford Univ Press -/- Gabriel Oak Rabin (2018) Grounding Orthodoxy and the Layered Conception Daniel Nolan (2018) Cosmic Loops Naomi Thompson (2018) Metaphysical Interdependence, Epistemic Coherentism, and Tuomas E. Tahko (2018) Holistic Explanation Fundamentality and Ontological Minimality Matteo Morganti (2018) The Structure of Physical Reality Beyond Foundationalism Nathan Wildman (2018) On Shaky Ground? Exploring the Contingent Fundamentality Thesis -/- (2015) M. Ringbauer, B. Duffus, C. Branciard1;3, E. G. Cavalcanti4, A. G. White1;2 & A. Fedrizzi: “Measurements on the reality of the wavefunction” . (shrink)

På mange måter er dette en bok som blir utgitt alt for sent. Det er den første antologien av sitt slag, og retter fokus på kvinnelige metafysikere som virket i den tidlige moderne perioden (16. og tidlig 17. århundre). Redaktør Emily Thomas skriver i introduksjonen at til tross for at flere antologier om moderne metafysikk allerede finnes, er kvinnelige filosofer fortsatt underrepresentert og den filosofiske kanon mannsdominert. De ni filosofene som blir omtalt i totalt 13 kapitler var alle originale og (...) velkjente tenkere i sin samtid, men har blitt glemt i filosofihistoriens løp. (shrink)

The literature acknowledges a distinction between immoral, amoral and moral management. This paper makes a case for the employee (at any level) as a moral agent, even though the paper begins by highlighting a body of evidence which suggests that individual moral agency is sacrificed at work and is compromised in deference to other pressures. This leads to a discussion about the notion of discretion and an examination of a separate, contrary body of literature which indicates that some individuals in (...) corporations may use their discretion to behave in a socially entrepreneurial manner. My underlying assumption is that CSR isn’t solely driven by economics and that it may also be championed as a result of a personal morality, inspired by employees’ own socially oriented personal values. A conceptual framework is put forward and it is suggested that individuals may be categorized as Active or Frustrated Corporate Social Entrepreneurs; Conformists or Apathetics, distinguished by their individualistic or collectivist personal values. In a discussion of the nature of values, this paper highlights how values may act as drivers of our behavior and pays particular attention to the values of the entrepreneur, thereby linking the existing debate on moral agency with the field of corporate social responsibility. (shrink)

In the light of Philipp Sarasin's work in Darwin und Foucault: Genealogie und Geschichte im Zeitalter der Biologie, the article delineates a genealogically articulated naturally produced culture and a cultured nature and discusses the genealogical implications of a carnal, becoming self in a world that could rightly be justified "as an aesthetical phenomenon." The article demonstrates the historicity and processual materiality as a conceptual platform for a combination of the notions of experienced carnality and a socially constructed body, demonstrating such (...) a historically embedded carnal body as a binding agent for the "social constructivist" and "biologist" approaches in sciences. Thus, the article builds a framework for the articulation of senseful, processual materiality on the backdrop of a nature-culture continuum via genealogy, suggesting the necessity for change of tone in the communication of human and life sciences via the understanding of a culturally endowed biology. (shrink)

Emotions often misfire. We sometimes fear innocuous things, such as spiders or mice, and we do so even if we firmly believe that they are innocuous. This is true of all of us, and not only of phobics, who can be considered to suffer from extreme manifestations of a common tendency. We also feel too little or even sometimes no fear at all with respect to very fearsome things, and we do so even if we believe that they are fearsome. (...) Indeed, instead of shunning fearsome things, we might be attracted to them. Emotions that seem more thought-involving, such as shame, guilt or jealousy, can also misfire. You can be ashamed of your big ears even though we can agree that there is nothing shameful in having big ears, and even though you judge that having big ears does not warrant shame. And of course, it is also possible to experience too little or even no shame at all with respect to something that is really shameful. Many of these cases involve a conflict between one’s emotion and one’s evaluative judgement. Emotions that are thus conflicting with judgement can be called ‘recalcitrant emotions’. The question I am interested in is whether or not recalcitrant emotions amount to emotional illusions, that is, whether or not these cases are sufficiently similar to perceptual illusions to justify the claim that they fall under the same general heading. The answer to this depends on what emotions are. For instance, the view that emotions are evaluative judgments makes it difficult to make room for the claim that emotional errors are perceptual illusions. Fearing an innocuous spider would simply amount to making the error of judging that the spider is fearsome while it is in fact innocuous. This might involve an illusion of some sort, but it certainly does not amount to anything like a perceptual illusion. In this chapter, I argue that recalcitrant emotions are a kind of perceptual illusion.. (shrink)

In this paper, we consider the question of whether there exists an essential relation between emotions and wellbeing. We distinguish three ways in which emotions and wellbeing might be essentially related: constitutive, causal, and epistemic. We argue that, while there is some room for holding that emotions are constitutive ingredients of an individual’s wellbeing, all the attempts to characterise the causal and epistemic relations in an essentialist way are vulnerable to some important objections. We conclude that the causal and epistemic (...) relation between emotions and wellbeing is much less strong than is commonly thought. (shrink)

This research explores the carnal, experienced self as processual and becoming, situating life as zoe (as per Braidotti) in the context of the Western culture, characterized by alienation (Fromm, Foucault). The study first addresses the ontological disposition of the carnal self and then turns to the concepts of life and death (Freud, Fromm), to explicate the tie between materiality and discourse conditions. Erich Fromm’s classical distinction of having and being is restated as a distinction of having and becoming, which are (...) then explored as complimentary ontological, cultural, and characterological directionalities. A genealogy of their mutual dynamics then allows situating the relations of carnal bodies and inorganic prosthesis (e.g. technologies) in the light of life considered as the necessary synthesis of forces of preservation and perpetual change, beyond subject-object duality. (shrink)

One difficulty in understanding recent debates is that not only have many terms been used to refer to weakness of will – “akrasia” and “incontinence” have often been used as synonyms of “weakness of will” – but quite different phenomena have been discussed in the literature. This is why the present entry starts with taxonomic considerations. The second section turns to the question of whether it is possible to freely and intentionally act against one’s better judgment.

In this paper, I develop a metasemantics for relaxed moral realism. More precisely, I argue that relaxed realists should be inferentialists about meaning and explain that the role of evaluative moral vocabulary is to organise and structure language exit transitions, much as the role of theoretical vocabulary is to organise and structure language entry transitions.

According to recent suggestions within the global pragmatism discussion, metaethical debate must be fundamentally re-framed. Instead of carving out metaethical differences in representational terms, it has been argued that metaethics should be given an inferentialist footing. In this paper, I put inferentialist metaethics to the test by subjecting it to the following two criteria for success: Inferentialist metaethicists must be able to save the metaethical differences between moral realism and expressivism, and do so in a way that employs understandings of (...) these metaethical accounts which would be acceptable to moral realists or expressivists who endorse an inferentialist theory of meaning. Two results follow from my discussion. The first concerns inferentialist metaethics more narrowly, casting doubts on inferentialists’ ability to fulfil the two criteria for success by showing that proposed metaethical demarcation attempts either meet the first criterion but violate the second, or pass the second criterion but fail the first. The second upshot pertains to the global pragmatism debate more widely, pressing the point that inferentialists have not as yet provided a convincing account of ontological commitment. (shrink)

The moral error theory generally does not receive good press in metaethics. This paper adds to the bad news. In contrast to other critics, though, I do not attack error theorists’ characteristic thesis that no moral assertion is ever true. Instead, I develop a new counter-argument which questions error theorists’ ability to defend their claim that moral utterances are meaningful assertions. More precisely: Moral error theorists lack a convincing account of the meaning of deontic moral assertions, or so I will (...) argue. (shrink)

This paper argues for a conception of the natural rights of non-human animals grounded in Kant’s explanation of the foundation of human rights. The rights in question are rights that are in the first instance held against humanity collectively speaking—against our species conceived as an organized body capable of collective action. The argument proceeds by first developing a similar case for the right of every human individual who is in need of aid to get it, and then showing why the (...) situation of animals is similar. I first review some of the reasons why people are resistant to the idea that animals might have rights. I then explain Kant’s conception of natural rights. I challenge the idea that duties of aid and duties of kindness to animals fit the traditional category of “imperfect duties” and argue that they are instead cases of “imperfect right.” I explain how you can hold a right against a group, and why it is legitimate to conceive of humanity as such a group. I then argue that Kant’s account of the foundation of property rights is grounded in a conception of the common possession of the Earth that grounds a right to aid and the rights of animals to be treated in ways that are consistent with their good. Finally, I return to the objections to the idea that animals have rights and offer some responses to them. (shrink)

After discussing de Sousa's view of emotion in akrasia, I suggest that emotions be viewed as nonconceptual perceptions of value (see Tappolet 2000). It follows that they can render intelligible actions which are contrary to one's better judgment. An emotion can make one's action intelligible even when that action is opposed by one's all-things-considered judgment. Moreover, an akratic action prompted by an emotion may be more rational than following one's better judgement, for it may be the judgement and not the (...) perception which is in error. By contrast, "cool" akrasia is genuinely puzzling; it is not clear whether it exists. (shrink)

Evaluative concepts and emotions appear closely connected. According to a prominent account, this relation can be expressed by propositions of the form ‘something is admirable if and only if feeling admiration is appropriate in response to it’. The first section discusses various interpretations of such ‘Value-Emotion Equivalences’, for example the Fitting Attitude Analysis, and it offers a plausible way to read them. The main virtue of the proposed way to read them is that it is well-supported by a promising account (...) of emotions, namely the Perceptual Theory of Emotions, which emphasises the analogies between emotions and sensory perceptual experiences. The second section considers a worry about whether concepts such as admirable are really evaluative. It is maintained that even though the arguments used to show that thick terms and concepts are not inherently evaluative can be transposed to affective concepts, these arguments can be resisted. So there is no need to abandon the intuitive claim that affective concepts are inherently evaluative. (shrink)

Recent debate about the error theory has taken a ‘formal turn’. On the one hand, there are those who argue that the error theory should be rejected because of its difficulties in providing a convincing formal account of the logic and semantics of moral claims. On the other hand, there are those who claim that such formal objections fail, maintaining that arguments against the error theory must be of a substantive rather than a formal kind. In this paper, we argue (...) that formal objections to the error theory cannot be eschewed but must be met head-on. (shrink)

COVID-19 vaccine refusal seems like a paradigm case of irrationality. Vaccines are supposed to be the best way to get us out of the COVID-19 pandemic. And yet many people believe that they should not be vaccinated even though they are dissatisfied with the current situation. In this paper, we analyze COVID-19 vaccine refusal with the tools of contemporary philosophical theories of responsibility and rationality. The main outcome of this analysis is that many vaccine-refusers are responsible for the belief that (...) they should not be vaccinated and epistemically rational in holding it. This is an important result because it provides insights into the legitimacy of certain public health policies. In particular, this result shows that a public health policy that would abandon the project of convincing certain vaccine-refusers with reasons – e.g., by simply making vaccination compulsory – is prima facie illegitimate. (shrink)

As with all other moral realists, so-called relaxed moral realists believe that there are moral truths. Unlike metaphysical moral realists, they do not take themselves to be defending a substantively metaphysical position when espousing this view, but to be putting forward a moral thesis from within moral discourse. In this paper, I employ minimalism about truth to examine whether or not there is a semantic analysis of the claim ‘There are moral truths’ which can support this moral interpretation of one (...) of moral realism’s key theses. My results are both discouraging and encouraging: Whilst I will argue that the claim ‘There are moral truths’ cannot be shown to be both moral and capable of demarcating relaxed realism from irrealism on the basis of a convincing semantic analysis that would be compatible with relaxed commitments, the moral interpretation of moral realism can be secured by modifying our understanding of what distinguishes relaxed realism from error-theoretic irrealism. Yet, we will see that this moral interpretation of moral realism does not ‘tumble out’ of the semantics provided for its central claims. Rather, hard work needs to be done before we can fully relax. (shrink)

It is generally accepted that there are two kinds of normative concepts : evaluative concepts, such as good, and deontic concepts, such as ought. The question that is raised by this distinction is how it is possible to claim that evaluative concepts are normative. Given that deontic concepts appear to be at the heart of normativity, the bigger the gap between evaluative and deontic concepts, the less it appears plausible to say that evaluative concepts are normative. After having presented the (...) main differences between evaluative and deontic concepts, and shown that there is more than a superficial difference between the two kinds, the paper turns to the question of the normativity of evaluative concepts. It will become clear that, even if these concepts have different functions, there are a great many ties between evaluative concepts, on the one hand, and the concepts of ought and of reason, on the other. (shrink)

Access to surrogacy is often cast in the language of rights. Here, I examine what form such a right could take. I distinguish between surrogacy as a right to assisted procreation, and surrogacy as a contractual right. I find the first interpretation implausible: it would give rise to claims against the state that no state can fulfil, namely the provision of sufficient surrogates to satisfy the need. Instead, I argue that the right to surrogacy can only be plausibly understood as (...) a contractual right. I then investigate two different sets of harms that are often employed to argue against such a contractual interpretation of the right to surrogacy: harm to women's interests in a gendered society, and harm to the sense of self of the surrogate. I assess both of these through the analytical lens of vulnerability. I find neither of them to be convincing arguments against surrogacy contracts. In conclusion, I agree that surrogacy contracts should be carefully regulated, but I disagree with those who call for prohibition of the right to surrogacy as a contractual right. (shrink)

Democracy is the central political issue of our age, yet debates over its nature and goals rarely engage with feminist concerns. Now that women have the right to vote, they are thought to present no special problems of their own. But despite the seemingly gender-neutral categories of individual or citizen, democratic theory and practice continues to privilege the male. This book reconsiders dominant strands in democratic thinking - focusing on liberal democracy, participatory democracy, and twentieth century versions of civic republicanism (...) - and approaches these from a feminist perspective. Anne Phillips explores the under-representation of women in politics, the crucial relationship between public and private spheres, and the lessons of the contemporary women's movement as an experience in participatory democracy. (shrink)

Much thought has been devoted to how metaethical disagreement between moral realism and expressivism can be saved once minimalism starts creeping. Very little thought has been given to how creeping minimalism affects error-theories’ disagreement with their metaethical competitors. The reason for this omission, I suspect, is found in the belief that whilst locating distinctive moral realist and expressivist positions within a minimalist landscape poses a severe challenge, no such difficulties are encountered when differentiating error-theories from moral realism and expressivism. In (...) the first part of this paper, I show that this belief is mistaken: Insofar as moral realists and error-theorists are still taken to disagree, creeping minimalism renders their disagreement moral, but makes these positions metaethically indistinguishable. In the second part of the paper, I present a modified inferentialist solution to the problem of creeping minimalism which seeks to put error-theories back on the metaethical map. Yet, this too comes at a cost, in that it significantly modifies our interpretation of error-theories. Whichever way we turn, then, creeping minimalism not only forces us to re-phrase metaethical positions in a way that is compatible with minimalism, but also requires us to change our very understanding of these positions. (shrink)

Philosophical discussion about the reality of sensory perceptions has been hijacked by two tendencies. First, talk about perception has been largely centered on vision. Second, the realism question is traditionally approached by attaching objects or material structures to matching contents of sensory perceptions. These tendencies have resulted in an argumentative impasse between realists and anti-realists, discussing the reliability of means by which the supposed causal information transfer from object to perceiver takes place. Concerning the nature of sensory experiences and their (...) capacity to provide access to reality, this article challenges the standard categories through which most arguments in this debate have been framed to date. Drawing on the underexplored case of olfaction, I first show how the details of the perception process determine the modalities of sensory experiences. I specifically examine the role of measurement and analyze its influence on the characterization of perceptions in olfaction. My aim is to argue for an understanding of perception through a process view, rather than one pertaining to objects and properties of objects. (shrink)

Ascribing moral responsibility in collective action cases is notoriously difficult. After all, if my individual actions make no difference with regard to the prevention of climate change, the alleviation of poverty, or the outcome of national elections, why ought I to stop driving, donate money, or cast my vote? Neither consequentialist nor non-consequentialist moral theories have straightforward responses ready at hand. In this contribution, I present a new suggestion which, based on thoughts about causal overdetermination along the lines of Mackie’s (...) INUS account, aims to show that causally overdetermined collective action cases are morally arbitrary in a way that makes it possible to ascribe moral responsibility even if individual actions make no difference. (shrink)

Are values objective or subjective? To clarify this question we start with an overview of the main concepts and debates in the philosophy of values. We then discuss the arguments for and against value realism, the thesis that there are objective evaluative facts. By contrast with value anti-realism, which is generally associated with sentimentalism, according to which evaluative judgements are grounded in sentiments, value realism is commonly coupled with rationalism. Against this common view, we argue that value realism can be (...) combined with sentimentalism, and we suggest that a plausible account, which we call ‘sentimental realism’, and according to which evaluative judgements are closely related to emotions, can be developped. (shrink)

Dog whistling—speech that seems ordinary but sends a hidden, often derogatory message to a subset of the audience—is troubling not just for our political ideals, but also for our theories of communication. On the one hand, it seems possible to dog whistle unintentionally, merely by uttering certain expressions. On the other hand, the intention is typically assumed or even inferred from the act, and perhaps for good reason, for dog whistles seem misleading by design, not just by chance. In this (...) paper, I argue that, to understand when and why it’s possible to dog-whistle unintentionally (and indeed, intentionally), we’ll need to recognize the structure of our linguistic practices. For dog whistles and for covertly coded speech more generally, this structure is a pair of practices, one shared by all competent speakers and the other known only to some, but deployable in the same contexts. In trying to identify these enabling conditions, we’ll discover what existing theories of communicated content overlook by focusing on particular utterances in isolation, or on individual speakers’ mental states. The remedy, I argue, lies in attending to the ways in which what is said is shaped by the temporally extended, socio-politically structured linguistic practices that utterances instantiate. (shrink)

In this article, I will consider whether, and in what way, doxastic states can harm. I’ll first consider whether, and in what way, a person’s doxastic state can harm her, before turning to the question of whether, and in what way, it can harm someone else.

Despite the widespread use of the notion of moral intuition, its psychological features remain a matter of debate and it is unclear why the capacity to experience moral intuitions evolved in humans. We first survey standard accounts of moral intuition, pointing out their interesting and problematic aspects. Drawing lessons from this analysis, we propose a novel account of moral intuitions which captures their phenomenological, mechanistic, and evolutionary features. Moral intuitions are composed of two elements: an evaluative mental state and a (...) feeling of rightness (FOR). We illustrate the phenomenology of the FOR with examples of non-moral and moral cases, and provide a biological and mechanistic account: the emergence of human reasoning capacities created a need for the co-evolution of a psychological system producing the feeling of rightness (the FORs). This system is triggered when we experience conflicting evaluations. The FORs renders evaluations resulting from rational deliberation less compelling than the evaluations produced by simple evolved systems. It thus facilitates optimal decision-making, preventing excessive interference by rational deliberation. Our account sheds light on why moral intuitions are so frequently experienced and why they are so compelling and resistant to argument. In addition, the account fuels interesting speculations about common metaethical intuitions. (shrink)

The article explores the concept of ‘life’ via processual ontology, contrasting the approaches of substance and processual ontologies, and investigates the link between ontological assumptions and sociopolitical discourses, stating that the predominant substance ontologies also promote an objectifying and anthropocentric framework in sociopolitical discourses and ethical approaches. Arguing for a necessary shift in the ontological conceptualization of life to enable environmentally-minded ethics for the future, the article explores the tie between the sociopolitical discourses embedded in a worldview that is grounded (...) in substance ontology and ethical frameworks. Whilst affirming this tie, this study also explicates the limitations and potential feasibility of a processual understanding of life, in the context of the existential disposition of the self-alienated lived-body self that is ontologically predisposed to objectification as a necessary pre-condition to human self-awareness. (shrink)

Metaethics is traditionally understood as a non-moral discipline that examines moral judgements from a standpoint outside of ethics. This orthodox understanding has recently come under pressure from anti-Archimedeans, such as Ronald Dworkin and Matthew Kramer, who proclaim that rather than assessing morality from an external perspective, metaethical theses are themselves substantive moral claims. In this paper, I scrutinise this anti-Archimedean challenge as applied to the metaethical position of expressivism. More precisely, I examine the claim that expressivists do not avoid moral (...) commitments when accounting for moral thought, but instead presuppose them; they do not look at ethics from the outside, but operate from within ethics. This paper defends the non-moral status of expressivism against anti-Archimedeanism by rejecting a new anti-Archimedean challenge which, on the basis of Hume’s Law, aims to exploit expressivist explanations of supervenience in order to show that expressivism is a substantive moral position. (shrink)

Most of those who hold that emotions involve appraisals also accept that the content of emotions is nonconceptual. The main motivation for nonconceptulism regarding emotions is that it accounts for the difference between emotions and evaluative judgements. This paper argues that if one assumes a broadly Fregean account of concepts, there are good reasons to accept that emotions have nonconceptual contents. All the main arguments for nonconceptualism regarding sensory perception easily transpose to the case of emotions. The paper ends by (...) responding to two important objections: firstly, that nonconceptualism rules out the possibility that emotions justify evaluative judgements and secondly, that nonconceptualism cannot account for the fact that some emotions have conceptually articulated cognitive bases. (shrink)