Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense.] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics and there are many new abstractions from advances in mathematics. Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)

Psychopathy refers to a range of complex behaviors and personality traits, including callousness and antisocial behavior, typically studied in criminal populations. Recent studies have used self-reports to examine psychopathic traits among noncriminal samples. The goal of the current study was to examine the underlying factor structure of the Self-Report of Psychopathy Scale–Short Form (SRP-SF) across complementary samples and examine the impact of gender on factor structure. We examined the structure of the SRP-SF among 2,554 young adults from three undergraduate samples (...) and a high-risk young adult sample. Using confirmatory factor analysis, a four-correlated factor model and a four-bifactor model showed good fit to the data. Evidence of weak invariance was found for both models across gender. These findings highlight that the SRP-SF is a useful measure of low-level psychopathic traits in noncriminal samples, although the underlying factor structure may not fully translate across men and women. (shrink)

In this brief, we argue that there is a diversity of ways in which humans (Homo sapiens) are ‘persons’ and there are no non-arbitrary conceptions of ‘personhood’ that can include all humans and exclude all nonhuman animals. To do so we describe and assess the four most prominent conceptions of ‘personhood’ that can be found in the rulings concerning Kiko and Tommy, with particular focus on the most recent decision, Nonhuman Rights Project, Inc v Lavery.

Is it conceptually possible for an event, L, to be the cause of an earlier event, E? Some writers have employed the so-called bilking argument to attempt to show that the idea of such backwards causation is incoherent . According to this argument, if we are presented with what someone claims to be a case of backwards causation, it would be possible in principle to wait for E to occur, and then intervene to prevent the occurrence of L, thus demonstrating (...) that E could not have been caused by L after all. Moreover, if our attempts to bilk L-type events having observed E-type events always fail, we have grounds to argue that any causal relationship between the two is not one of backwards causation, but of ordinary, forwards, earlier-to-later causation.Does the bilking argument succeed in showing backwards causation to be incoherent? Before answering this question, let us deal with a far simpler reason for deeming backwards causation incoherent, whose elucidation now will be useful later. To those attracted to the view that temporal order is determined by causal order, 1 backwards causation may seem incoherent because on this view a cause is by definition earlier than its effect. I do not take issue with this view, and wish my conception of backwards causation to be compatible with it. 2 By ‘backwards causation’, I mean causation that runs in the opposite direction to some other causal processes, such that the temporal order entailed by such backwards causation is the reverse of that entailed by those other causal processes. In most philosophical discussions of backwards causation, we are at least implicitly given reasons to believe that these other causal processes dictate the …. (shrink)

Three years before the publication of L'Erotisme of George Bataille (1957), the bogotanian thinkerNicolas Gomez Davila, at instances of his brother, published his first work with the succinct and modest title ofNotes (1954). Two different philosophical traditions meet in the study of the same topic, showing that flesh, skin,sensuality, pleasure and other related themes connect each other with all dimensions of human life, and that no onereflect, in an honest and serious way about it, may relegate them or hide them (...) behind the folding screen of taboo.More than an erudition work, this will be the pretext to recognize the great input of them both to the history of theideas about the problem of eroticism. (shrink)

Cette étude défend l’idée que, contrairement à l’opinion de Latour sur la nécessité de laisser de côté l’épistémologie pour traiter de tout ce qui a de la valeur pour la science, Mario Bunge a systématiquement construit une épistémologie détaillée et approfondie. La stratégie argumentative consistera à montrer (a) qu’il est faux que nous n’avons jamais été modernes (b) que l’épistémologie est là pour de bon et (c) que Mario Bunge soutient un réalisme scientifique fort, une version du matérialisme, du systémisme (...) et de l’émergentisme, comportant une dimension morale (il existe des valeurs objectives comme la vérité, la paix et la justice qui méritent d’être étudiées). Ensuite, le réalisme de Bunge rejette la neutralité axiologique rendant les scientifiques responsables de leurs actions. Bunge a toujours été moderne et continue à enrichir ses propres positions. (shrink)

In this paper I respond to Rebecca Kukla's (2014) "Commentary on Karyn Freedman, "Testimony and Epistemic Risk: The Dependence Account."".

REPRODUÇÃO ANIMAL: O CICLO ESTRAL DE BOVINOS LEITEIROS – Desenvolvimento Folicular, Corpo Lúteo e Etapas do Estro ANIMAL REPRODUCTION: THE OESTROUS CYCLE OF DAIRY BOVINES -Follicular Development, Corpus Luteum and Stages of Estrus Apoio: Emanuel Isaque Cordeiro da Silva Departamento de Zootecnia da UFRPE E-mail: [email protected] WhatsApp: (82)98143-8399 FISIOLOGIA CLÍNICA DO CICLO ESTRAL DE BOVINOS LEITEIROS 1. RESUMO A fêmea bovina apresenta ciclos estrais em intervalos de 19 a 23 dias e estes só são interrompidos durante a gestação ou devido (...) a alguma patologia. O estro é o período de aceitação da cópula e tem uma duração de 8 a 18 horas. Durante o metaestro ocorre a ovulação e se desenvolve o corpo lúteo. O diestro é o estágio mais longo do ciclo e é caracterizado pela presença de um corpo lúteo. Se a gestação não for estabelecida, o endométrio segrega prostaglandina F2α(PGF2α) o que induz a luteólise, reiniciando assim um novo ciclo. 2. EIXO HIPOTÁLAMO-HIPÓFISE-OVÁRIO As hormonas são substâncias produzidas por diferentes células do organismo que exercem funções específicas em outras células (células brancas). Algumas hormonas atuam na mesma célula que a secreta (atividade autocrina), outras nas células vizinhas (atividade parácrina) e outras são transportadas pelo sangue e exercem a sua função em células de outros órgãos (atividade endócrina). Existem outros tipos de hormônios que comunicam a diferentes indivíduos e são conhecidos como feromônios. Os feromônios regulam diferentes funções, entre as quais se destacam as reprodutivas. O hipotálamo encontra-se na base do cérebro, é formado por núcleos pares de neurônios e comunica-se com a hipófise através de um sistema circulatório especializado conhecido como sistema porta-hipotálamo-hipofisário. Os neurônios da área ventromedial e da área pré-óptica do hipotálamo secretam a hormona libertadora das gonadotropinas (GnRH), que por sua vez chega à hipófise através do sistema porta-hipotálamo-hipofisário e estimula a secreção da hormona luteinizante (LH) e da hormona folículo estimulante (FSH). A LH mantém um padrão de secreção paralelo à secreção da GnRH; ou seja, uma parcela de GnRH corresponde a uma parcela de LH, ao contrário da FSH que tem uma produção basal elevada inibida pelo estradiol e inibina, por este motivo, a sua secreção não apresenta um padrão pulsante semelhante à LH. A GnRH tem duas formas de secreção: a primeira é pulsante ou tônica, regulada por estímulos externos (fotoperíodo, bioestimulação, amamentação) e por estímulos internos (metabolitos, hormonas metabólicas, hormonas sexuais); a segunda forma é pré-ovulatória ou cíclica e é estimulada pelos estrogênios durante o estro e inibida pela progesterona. A secreção de alguns hormônios, bem como diversos processos fisiológicos, são sincronizados com a duração do dia e da noite (ritmos endógenos). A luz é percebida pelos fotorreceptores da retina e o sinal luminoso chega à glândula pineal através de conexões neuronais (trato retino-hipotalâmico). Na glândula pineal, o estímulo produzido pela luz inibe a síntese da melatonina. Desta forma, a duração do dia e da noite (fotoperíodo) é registada pelas variações nas concentrações da melatonina. Na vaca, sabe-se que o fotoperíodo influencia alguns processos reprodutivos, embora não seja, em sentido estrito, uma espécie com um padrão reprodutivo sazonal. Os feromônios sexuais são excretados através da urina, fezes e fluidos corporais; eles são percebidos pelo epitélio olfatório e órgão vomeronasal. Posteriormente, algumas vias nervosas, estimulam no hipotálamo a frequência dos pulsos de secreção da GnRH. A exposição a feromonas femininas provoca no macho um aumento na frequência de secreção do LH e isto por sua vez aumenta as concentrações de testosterona. Os feromônios masculinos induzem na fêmea um aumento da frequência de secreção do LH, estimulando o crescimento folicular e a secreção de estradiol. A estimulação sexual provocada pelo macho ou pela fêmea é denominada bioestimulação. As alterações na condição corporal estão positivamente correlacionadas com as concentrações séricas de insulina, fator de crescimento semelhante à insulina tipo I (IGF- I) e leptina. Assim, quanto maior a classificação da condição corporal, maior é a concentração sérica destas hormonas, que atuam como sinais que chegam ao hipotálamo e modificam a frequência de secreção da GnRH. Por exemplo, a transição do anestro para a ciclicidade coincide com um aumento da condição corporal e das concentrações de insulina, IGF- I e leptina (figura 1). Figura 1. A transição do anestro para a ciclicidade coincide com um aumento da condição corporal e das concentrações de insulina, IGF- I e leptina. Estas hormonas atuam como sinais que chegam ao hipotálamo e aumentam a frequência de secreção da GnRH. Fonte: GALINA, et al. 2008. Os estrogênios podem ter um feedback positivo ou negativo sobre a secreção da GnRH, o que depende da fase do ciclo reprodutivo. Em animais pré-púberes e em anestro pós-parto, os estrogênios inibem a secreção de GnRH, mas durante o período de proestro e estro há uma estimulação para a secreção de GnRH. A progesterona reduz a secreção da GnRH, bem como a resposta da hipófise à GnRH, inibindo assim a maturação folicular e a ovulação. Por esta razão, a progesterona foi utilizada com sucesso como contraceptivo em humanos e para o controle artificial da reprodução em animais domésticos (figura 2). Figura 2. Retroalimentação entre o hipotálamo, hipófise e o ovário. A GnRH estimula na hipófise a síntese e secreção de LH e FSH. Na fase pré-púbere e no anestro pós-parto, os estrogênios inibem a secreção de GnRH, enquanto no proestro e estro, estimulam-na. A progesterona inibe a secreção da GnRH e diminui a resposta da hipófise à GnRH. Os estrogênios e a inibina suprimem a secreção de FSH diretamente na hipófise. Fonte: GALINA, et al. 2008. Os neurônios secretores da GnRH não têm receptores para estrogênios nem progesterona, pelo que estas hormonas não têm forma de regular diretamente a secreção da GnRH. Existe um grupo de neurônios hipotalâmicos que exprimem o gene Kiss-1 que codifica o peptídeo kisspeptina. Os neurônios secretores da GnRH têm receptores para este peptídeo, de modo que a kisspeptina fornece a informação aos neurônios secretores da GnRH em relação às concentrações de hormônios sexuais. A kisspeptina é um potente estimulador (secretagogo) da secreção da GnRH e é muito provável que nos próximos anos venha a fazer parte dos recursos hormonais para o controle artificial da reprodução, não só nos bovinos, mas em todas as espécies domésticas. 3. DESENVOLVIMENTO FOLICULAR O ovário é responsável pela produção de ovócitos e pela síntese de hormônios sexuais, estrogênios e progesterona, que promovem e regulam a fertilização do ovócito e a manutenção da gestação. O ovócito encontra-se no interior do folículo ovárico rodeado por células granulosas que participam de forma ativa no seu crescimento e maturação. As experiências in vitro demonstram a dependência dos ovócitos das células da granulosa, assim, quando os ovócitos são induzidos a amadurecer devem estar rodeados por várias camadas de células da granulosa para que este processo seja bem sucedido, caso contrário, não adquirem o potencial para desenvolver um embrião. Embora as células da teca interna não estejam em contato direto com o ovócito, seu papel na maturação deste o exercem mediante a produção de andrógenos, mesmos que são convertidos em estrogênios pelas células da granulosa. Além disso, as células da teca favorecem o estabelecimento da rede capilar que apoia o desenvolvimento folicular. Por outro lado, os novos conhecimentos indicam que o ovócito não é um elemento passivo no desenvolvimento folicular, mas regula a função das células foliculares; o que significa que ele próprio participa na criação de um microambiente ideal para a sua maturação. Além disso, é possível que o ovócito tenha um papel na ativação do desenvolvimento dos folículos primordiais. A fêmea bovina nasce com aproximadamente 200 mil folículos, dos quais muito poucos se ativam e iniciam seu crescimento, e a maior parte deles sofre atresia em diferentes etapas de desenvolvimento. Ao nascimento, os folículos estão na fase mais elementar e são conhecidos como folículos primordiais. Posteriormente estes folículos se ativam e se transformam em folículos primários e secundários; até este momento os folículos não têm antro (etapa pré-antral) e seu desenvolvimento é independente das gonadotropinas. Quando os folículos formam o antro são conhecidos como folículos terciários e seu desenvolvimento é dependente das gonadotropinas (etapa antral). O crescimento folicular no estágio antral ocorre em forma de ondas e cada onda começa com um aumento nos níveis de FSH, o qual promove o crescimento de um grupo de cinco a seis folículos (~4 mm de diâmetro); este processo é conhecido como recrutamento. Subsequentemente, um único folículo continua a crescer (folículo dominante), o que provoca um aumento das concentrações de estrogênios e inibina, uma diminuição das concentrações de FSH e atresia dos folículos subordinados, pois eles dependem totalmente desta hormona, enquanto o folículo dominante continua o seu desenvolvimento estimulado pela LH. O folículo dominante perdura de quatro a seis dias e se não chega a ovular, sofre atresia. Após a atresia do folículo dominante, diminuem-se os níveis de estrogênio e inibina, observa-se um aumento das concentrações de FSH e inicia-se uma nova onda folicular. O folículo dominante que está presente quando o corpo lúteo sofre regressão, continua seu desenvolvimento e ovula, em resposta ao pico pré-ovulatório de LH. Além de promover a liberação do ovócito, a secreção pré-ovulatória de LH regula a formação do corpo lúteo a partir das células foliculares, processo conhecido como luteinização. Durante o ciclo estral são apresentadas de duas a três ondas foliculares. As vacas com três ondas foliculares têm uma fase lútea mais longa e, consequentemente, um ciclo estral mais longo, de 22 a 23 dias; enquanto as vacas com duas ondas apresentam um ciclo estral de 18 a 21 dias. Nas vacas leiteiras, cerca de 70% apresentam duas ondas foliculares, enquanto 30% exibem três ondas (figura 3 e 4). Nas vacas com duas ondas foliculares, o período de dominação folicular é maior do que nas de três ondas. O tempo de dominação influencia o potencial dos ovócitos para desenvolver um embrião viável; assim, a porcentagem de concepção é menor quando ovulam folículos que tiveram mais dias de dominação dos que quando ovulam folículos com menor tempo de dominação (figura 5). Figura 5. O crescimento folicular no estágio antral ocorre na forma de ondas. Cada onda começa com um aumento nas concentrações de FSH, o que promove o recrutamento de cinco a seis folículos (~4 mm de diâmetro). Posteriormente um único folículo continua crescendo (folículo dominante), enquanto seus companheiros (subordinados) sofrem atresia. O folículo dominante perdura de quatro a seis dias e se não chega a ovular, sofre atresia. Após a atresia do folículo dominante observa-se um aumento das concentrações de FSH, iniciando-se uma nova onda folicular. 3.1 Ovulação múltipla Nos últimos anos tem-se observado um aumento na proporção de vacas com ovulação múltipla (20% x 1% em novilhas), o que tem provocado um aumento da proporção de partos gêmeos (8% x 1% em novilhas). A frequência de vacas com ovulação múltipla está associada com a alta produção de leite; de modo que, as vacas que produzem menos de 40 kg mostram 6% de ovulações múltiplas e aquelas que produzem mais de 50 kg alcançam até 50%. A causa deste fenômeno ainda é obscura, contudo, observaram-se diferenças nas concentrações de FSH, de tal forma que as vacas que desenvolvem de dois a três folículos dominantes numa onda folicular, apresentam níveis de FSH mais elevados que as vacas que têm apenas um folículo dominante. Em vacas em lactação, a concentração de progesterona é baixa devido ao aumento do metabolismo hepático, o que aumenta a sua taxa de eliminação. Foi observado que as vacas que tiveram uma fase lútea com níveis de progesterona mais elevados, no ciclo anterior à inseminação, apresentam menos ovulações múltiplas em comparação com as vacas que tiveram níveis de progesterona mais baixos. Propõe-se que as baixas concentrações de progesterona permitam um aumento da frequência de secreção da GnRH e, consequentemente, da LH e da FSH, favorecendo a predominância múltipla e, eventualmente, a ovulação de mais de um folículo. Nos rebanhos leiteiros, as gestações gêmeas não são desejáveis porque aumenta o risco de perda da gestação e, se esta chegar ao término, haverá o risco de perda da gestação e, se esta for concluída, o risco de distorcia é consideravelmente mais elevado (figuras 6, 7, 8 e 9). Figura 6. As baixas concentrações de progesterona sérica nas vacas em lactação permitem um aumento da frequência de secreção da GnRH, bem como o aumento da LH e da FSH. Isto favorece a dominação múltipla e eventualmente a ovulação de mais de um folículo. Esta figura mostra a dominância de dois folículos em cada onda folicular (codominância). Figura 7. Ovários de uma vaca leiteira em diestro com três folículos dominantes. Figura 8. Ovários de uma vaca leiteira com três corpos lúteos. Figura 9. Ovários de uma vaca leiteira com dois corpos hemorrágicos. Fonte: Acervo pessoal do autor. IFPE, 2017-18. 4. DESENVOLVIMENTO E CONTROLE DA FUNÇÃO DO CORPO LÚTEO Quando o folículo dominante completa sua maturação, ele produz níveis de estrogênio suficientes para provocar a liberação máxima da GnRH, o que desencadeia o pico pré-ovulatório da LH. Esta secreção de LH provoca a ovulação e inicia as mudanças para que o folículo se transforme em um corpo lúteo, processo conhecido como luteinização. A luteinização compreende todas as mudanças morfológicas, endócrinas e enzimáticas que ocorrem no folículo ovulatório até que este se transforme num corpo lúteo. O processo de luteinização começa a partir da elevação pré-ovulatória de LH; mesmo antes da ovulação. A luteinização do folículo dominante (≥8 mm de diâmetro) pode ser induzida hormonalmente pela injeção de GnRH ou gonadotropina coriónica humana (hCG). A ovulação ocorre em média 30 horas após o pico pré-ovulatório de LH. A secreção pré-ovulatória de LH desencadeia a liberação de enzimas proteolíticas e de mediadores da inflamação na parede folicular, as quais degradam o tecido conjuntivo e ocasionam morte celular. Posteriormente, a PGF2α induz contrações da teca externa, levando à ruptura folicular e à expulsão do ovócito. Após a ovulação, as células da teca interna e da granulosa migram e distribuem-se nas paredes do folículo. As células da teca interna se diferenciam e se multiplicam em células lúteas pequenas, enquanto que as células da granulosa se hipertrofiam e dão origem às células lúteas grandes. Estas alterações são facilitadas pela ruptura da membrana basal que separa a camada celular da granulosa da teca interna. Em forma paralela começa a formação de uma ampla rede de capilares que se distribuem em todo o corpo lúteo em formação, e chegam a constituir até 20% do volume desta estrutura (figuras 10 e 11). A progesterona é o principal produto de secreção do corpo lúteo. No quinto dia do ciclo estral, as concentrações séricas desta hormona são superiores a 1 ng/ ml, indicando que o corpo lúteo adquiriu a sua plena funcionalidade. A progesterona atua basicamente sobre os órgãos genitais da fêmea, sendo responsável pela preparação do útero para o estabelecimento e manutenção da gestação. Na mucosa do oviduto e do útero, estimula a secreção de substâncias que promovem o desenvolvimento do embrião, até que este comece a nutrir-se através da placenta. A progesterona suprime a resposta imunitária do útero, o que é necessário para tolerar o embrião, já que este é um tecido estranho para a vaca. Além disso, a progesterona evita as contrações do útero, fecha o colo do útero e modifica as características do muco cervical, tornando-o mais viscoso, impedindo a passagem de agentes estranhos para o interior do útero. Na glândula mamária estimula o desenvolvimento do sistema alveolar, preparando-a para a síntese e a secreção de leite. 5. REGRESSÃO DO CORPO LÚTEO A regressão lútea é um processo ativo ocasionado pela secreção uterina da PGF2α. O mecanismo pelo qual se inicia a síntese e secreção da PGF2α depende de uma interação entre o corpo lúteo, os folículos e o útero. Os estrogênios produzidos no folículo dominante desempenham um papel importante no início da secreção de PGF2α, uma vez que promovem a síntese de receptores para oxitocina. Além disso, os estrogénios estimulam no endométrio a produção da fosfolipase A e da ciclooxigenase; enzimas indispensáveis para a síntese da PGF2α. Durante o ciclo estral, a progesterona inibe a síntese da PGF2α através da supressão da formação de receptores para o estradiol. Após um período de 12 a 14 dias de exposição à progesterona, as células endometriais tornam-se insensíveis à progesterona. Quando isso ocorre, as células endometriais sintetizam receptores para estradiol, permitindo que o estradiol produzido no folículo dominante estimule a síntese de receptores para oxitocina. Neste momento, o endométrio está pronto para sintetizar e secretar PGF2α, em resposta ao estímulo da oxitocina. A primeira secreção de oxitocina é de origem hipotalâmica, o que desencadeia o primeiro pulso de PGF2α. Os seguintes episódios de PGF2α são induzidos pela oxitocina produzida no corpo lúteo. A PGF2α é secretada em episódios (pulsos) com intervalos de seis a oito horas, sendo necessários cinco a seis episódios para a luteólise ocorrer. Se a PGF2α não seguir este padrão de secreção, a regressão do corpo lúteo falhará. Além da PGF2α de origem uterina, o corpo lúteo também produz PGF2α, que aumenta o efeito luteolítico. A falta de sensibilidade à PGF2α observada nos corpos lúteos imaturos (primeiros cinco dias após a ovulação) deve-se ao fato de, neste período, o corpo lúteo ainda não produzir PGF2α (figura 12, 13 e 14). 6. ETAPAS DO CICLO ESTRAL O ciclo estral é dividido em quatro etapas bem definidas. 6.1 Estro Neste estágio a fêmea aceita a cópula ou a monta de outra vaca. O estro é provocado pelo aumento significativo das concentrações de estradiol produzido pelo folículo pré-ovulatório e pela ausência de um corpo lúteo. A duração desta etapa é de 8 a 18 horas. 6.2 Metaestro O metaestro é a etapa posterior ao estro, tem uma duração de quatro a cinco dias. Durante esta etapa ocorre a ovulação e se desenvolve o corpo de lúteo. Após a ovulação, observa-se uma depressão no lugar ocupado pelo folículo ovulatório (depressão ovulatória) e, posteriormente, se desenvolve o corpo hemorrágico (corpo lúteo em processo de formação). Durante o metaestro, as concentrações de progesterona começam a aumentar até atingirem níveis superiores a 1 ng/ml, momento a partir da qual considera-se que o corpo lúteo atingiu a maturidade. O momento em que as concentrações de progesterona são superiores a 1 ng/ml toma-se como critério fisiológico a determinação do fim do metaestro e o início do diestro. Um evento hormonal que se destaca neste período consiste na apresentação do pico pós-ovulatório de FSH, o qual desencadeia a primeira onda de desenvolvimento folicular. Algumas vacas apresentam sangramento conhecido como sangramento metaestral (figura 15). 6.3 Diestro O diestro é o estágio de maior duração do ciclo estral, de 12 a 14 dias. Durante este estágio o corpo lúteo mantém sua plena funcionalidade, o que se reflete em concentrações sanguíneas de progesterona, maiores que 1 ng/ml. Além disso, nesta fase, pode-se encontrar folículos de tamanho diferente devido às ondas foliculares. Após 12-14 dias de exposição à progesterona, o endométrio começa a secretar PGF2α em um padrão pulsátil, ao qual termina com a vida do corpo lúteo e com o diestro. Em termos endócrinos, quando o corpo lúteo perde a sua funcionalidade, ou seja, quando as concentrações de progesterona diminuem abaixo de 1 ng/ml, finaliza-se o diestro e começa o proestro. Convém mencionar que durante esta fase, a LH é secretada com uma frequência muito baixa e a FSH tem incrementos responsáveis pelas ondas foliculares. 6.4 Proestro O proestro caracteriza-se pela ausência de um corpo lúteo funcional e pelo desenvolvimento e maturação do folículo ovulatório. O proestro na vaca dura de dois a três dias. Um evento hormonal característico desta etapa é o aumento da frequência dos pulsos de secreção de LH que levam à maturação final do folículo ovulatório e ao aumento do estradiol sérico, que desencadeia o estro. Para além da classificação do ciclo estral acima descrita, existe outra que divide o ciclo em duas fases: progestacional (lútea) e estrogênica (folicular). A fase progestacional inclui o metaestro e o diestro, e a fase estrogênica ao proestro e estro (figura 16). Figura 16. Etapas do ciclo estral. Adaptado e elaborado a partir de FERREIRA, 2010. 7. CONCLUSÕES PRÉVIAS  O ciclo estral dura de 19 a 23 dias.  A vaca é receptiva durante 8 a 18 horas (estro).  Ao nascimento uma bezerra tem cerca de 200 mil folículos primordiais.  Durante o ciclo estral se apresentam de duas a três ondas foliculares.  De cinco a seis folículos são recrutados em cada onda folicular.  Cerca de 70% das vacas têm duas ondas foliculares e 30% apresentam três ondas.  Entre 10 e 20% das vacas têm ovulações múltiplas (dois a três folículos) e 8% têm partos gêmeos.  A ovulação ocorre 30 horas após o pico pré-ovulatório de LH.  A secreção pré-ovulatória de LH é de 15 a 30 ng/ml.  12 a 14 dias são necessários para que o endométrio se torne insensível à progesterona e comece a secretar PGF2α. - São necessários cinco a seis pulsos de PGF2α com um intervalo de oito horas para ocasionar a luteólise.  O corpo lúteo não é sensível à PGF2α nos primeiros cinco dias do ciclo estral. Emanuel Isaque Cordeiro da Silva – Departamento de Zootecnia da UFRPE Recife, 2020. REFERÊNCIAS BIBLIOGRÁFICAS ALVES, Nadja Gomes; PEREIRA, Marcos Neves; COELHO, Rodrigo Michelini. Nutrição e reprodução em vacas leiteiras. Revista Brasileira de Reprodução Animal, p. l1248-l1248, 2009. ARBOLEDA, José Leonardo Ruiz; URIBE-VELÁSQUEZ, Luis Fernando; OSORIO, José Henry. Factor de crecimiento semejante a insulina tipo 1 (IGF-1) en la reproducción de la hembra bovina. Vet. zootec, v. 5, n. 2, p. 68-81, 2011. BARUSELLI, Pietro Sampaio; GIMENES, Lindsay Unno; SALES, José Nélio de Sousa. Fisiologia reprodutiva de fêmeas taurinas e zebuínas. Revista Brasileira de Reprodução Animal, v. 31, n. 2, p. 205-211, 2007. COLE, H. H.; CUPPS, P. T. Reproduction in domestic animals. 1ª ed. Londres: Academic Press, 1977. DA SILVA, Emanuel Isaque Cordeiro. Características Gerais dos Bovinos/General Characteristics of Cattle Bovine. Disponível em: ———. Acesso em: Fevereiro de 2020. DA SILVA, Emanuel Isaque Cordeiro. Definição de Conceitos Básicos na Reprodução Animal: Fertilidade, Fecundidade e Prolificidade-Suínos. Philarchive. Disponível em: ———. Acesso em: Fevereiro de 2020. DA SILVA, Emanuel Isaque Cordeiro. REPRODUÇÃO ANIMAL: OVULAÇÃO, CONTROLE E SINCRONIZAÇÃO DO CIO. Disponível em: ———. Acesso em: Fevereiro de 2020. DO VALLE, Ezequlel Rodrigues. O ciclo estral de bovinos e métodos de controle. Campo Grande: EMBRAPA-CNPGC, 1991. FERREIRA, A. M. Reprodução da fêmea bovina: fisiologia aplicada e problemas mais comuns. Juiz de Fora: Editar, 2010. GALINA HIDALGO, Carlos et al. Reproducción de animales domésticos. México: Limusa, 1988. HAFEZ, E. S. E.; HAFEZ, B. Reprodução animal. São Paulo: Manole, 2004. McDONALD, L.E. Veterinary endocrinology and reproduction. 3.ed. Philadelphia: Lea & Febiger, 1980. MELLO, R. R. C. et al. Desenvolvimento folicular inicial em bovinos. Revista Brasileira de Reprodução Animal, v. 37, n. 4, p. 328-333, 2013. MELLO, Raquel Rodrigues Costa et al. Aspectos da dinâmica folicular em bovinos. Agropecuária Científica no Semiárido, v. 10, n. 4, p. 01-06, 2015. NEBEL, Ray; DEJARNETTE, M. Anatomía y fisiología de la reproducción bovina. SELECT SIRES INC, v. 6, 2011. PALMA, Gustavo A. Biotecnología de la reproducción. Balcarce: Instituto Nacional de Tecnología Agropecuaria, 2008. PEREIRA, Elias de Oliveira. Fisiologia da reprodução em vacas leiteiras: REVISÃO DE LITERATURA. TCC Medicina Veterinária. Ituverava: FAFRAM, 2019. PETERS, A. R.; BALL, P. J. H. Reprodução em bovinos. São Paulo: Editora Roca, 2006. PRIETO-GÓMEZ, Bertha; VELÁZQUEZ-PANIAGUA, Mireya. Fisiología de la reproducción: hormona liberadora de gonadotrofinas. Rev Fac Med UNAM, v. 45, n. 6, p. 252-57, 2002. SALISBURY, Glenn Wade; LODGE, J. R.; VANDEMARK, N. L. Fisiología de la reproducción e inseminación artificial de los bóvidos. Zaragoza: Acribia, 1978. VIVEIROS, Ana Tereza de Mendonça. Fisiologia da reprodução de bovinos. Lavras: UFLA, 1997. (shrink)

It is a truism that humans are social animals. Thus, it is no surprise that we understand the world, each other, and ourselves in terms of social kinds such as money and marriage, war and women, capitalists and cartels, races, recessions, and refugees. Social kinds condition our expectations, inform our preferences, and guide our behavior. Despite the prevalence and importance of social kinds, philosophy has historically devoted relatively little attention to them. With few exceptions, philosophers have given pride of place (...) to the kinds studied by the natural sciences, especially physics. However, philosophical interest in social kinds is growing in recent years. I critically examine answers to a cluster of related questions concerning the metaphysics of social kinds. Are social kinds natural kinds? Do social kinds have essences? Are social kinds mind dependent? Are social kinds real? (shrink)

Former NAACP chapter head Rachel Dolezal's attempted transition from the white to the black race occasioned heated controversy. Her story gained notoriety at the same time that Caitlyn Jenner graced the cover of Vanity Fair, signaling a growing acceptance of transgender identity. Yet criticisms of Dolezal for misrepresenting her birth race indicate a widespread social perception that it is neither possible nor acceptable to change one's race in the way it might be to change one's sex. Considerations that support transgenderism (...) seem to apply equally to transracialism. Although Dolezal herself may or may not represent a genuine case of a transracial person, her story and the public reaction to it serve helpful illustrative purposes. (shrink)

Quadruple Helix Collaborations (QHCs) is a cooperation model in which industry, government, academia, and the public interact to innovate. This paper analyses the impact of a training intervention to provide specific knowledge, skills, and attitudes to deal with barriers commonly found in the progress of QHCs. We designed, implemented, and evaluated three training programs in Austrian, Colombian, Danish, and Spanish institutions. We analysed trainees’ (n = 66) and trainers’ (n = 9) perceptions to identify the competencies acquired with the intervention (...) and the approach’s limitations. We used online questionnaires (35 trainees; 9 trainers), semi-structured interviews (10 trainees), and a focus group (6 trainers). Trainees answered positively regarding their self-perception about the impact of the course and highlighted the acquisition of inspiration for their practice (score 4.1 out of 5.0) and knowledge (3.7). In contrast, they perceived that a deeper interaction with other participants (2.7) was challenging. After the courses, 74% of respondents indicated that they know more about how QHCs work in practice, and 86% about collaboration or engagement methods. Moreover, participants plan to be more sensitive towards setting common goals (71%) and power imbalances (63%). Trainers’ perceptions align with those expressed by participants, except that they considered that the interaction amongst participants during the course was higher. Qualitative analysis of interviews with participants and the focus group with trainers provides more detail about the strengths and weaknesses of the intervention. Our study shows that the collaborative design and implementation of training impact the participant’s learning competencies, with potential implications in their medium- to long-term practice. (shrink)

Traditionally, social entities (i.e., social properties, facts, kinds, groups, institutions, and structures) have not fallen within the purview of mainstream metaphysics. In this chapter, we consider whether the exclusion of social entities from mainstream metaphysics is philosophically warranted or if it instead rests on historical accident or bias. We examine three ways one might attempt to justify excluding social metaphysics from the domain of metaphysical inquiry and argue that each fails. Thus, we conclude that social entities are not justifiably excluded (...) from metaphysical inquiry. Finally, we ask how focusing on social entities could change the character of metaphysical inquiry. We suggest that starting from examples of social entities might lead metaphysicians to rethink the assumption that describing reality in terms of intrinsic, independent, and individualistic features is preferable to describing it in terms of relational, dependent, and non-individualistic features. (shrink)

In this essay, I reply to critiques of my article “In Defense of Transracialism.” Echoing Chloë Taylor and Lewis Gordon’s remarks on the controversy over my article, I first reflect on the lack of intellectual generosity displayed in response to my paper. In reply to Kris Sealey, I next argue that it is dangerous to hinge the moral acceptability of a particular identity or practice on what she calls a collective co-signing. In reply to Sabrina Hom, I suggest that relying (...) on the language of passing to describe transracialism is potentially misleading. In reply to Tina Botts, I both defend analytic philosophy of race against her multiple criticisms and suggest that Botts’s remarks risk complicity with a form of transphobia that Talia Mae Bettcher calls the Basic Denial of Authenticity. I end by gesturing toward a more inclusive understanding of racial identity. (shrink)

1 Some philosophers defend the thesis that women are adult human females. Call this the adult human female thesis (AHF). There are two versions of this thesis—one modal and one definitional. Accord...

Previous work in Game Studies has centered on several loci of investigation in seeking to understand virtual gameworlds. First, researchers have scrutinized the concept of the virtual world itself and how it relates to the idea of “the magic circle”. Second, the field has outlined various forms of experienced “presence”. Third, scholarship has noted that the boundaries between the world of everyday life and virtual worlds are porous, and that this fosters a multiplicity of identities as players identify both with (...) themselves-offline and themselves-in-game. Despite widespread agreement that these topics are targets for research, so far those working on these topics do not have mutually agreed-upon framework. Here we draw upon the work of Alfred Schutz to take up this call. We provide a phenomenological framework which can be used to describe the phenomena of interest to Game Studies, as well as open new avenues of inquiry, in a way acceptable and useful to all. This helps to distinguish the core of the field from the supplemental theoretical and critical commitments which characterize diverse approaches within the field. (shrink)

Expressions of emotion pose a serious challenge to the view that we perceive other people’s emotions directly. If we must perceive expressions in order to perceive emotions, then it is only ever the expressions that we are directly aware of, not emotions themselves. This paper develops a new response to this challenge by drawing an analogy between expressions of emotion and perceptual media. It is through illumination and sound, the paradigmatic examples of perceptual media, that we can see and hear (...) objects around us. Instead of screening these objects from view, however, they enable our perception while being transparent to us. With reference to perceptual constancy and transparency, I show how expressions show up in our experience of emotions in a surprisingly similar way. Given this, we can understand expressions as the media _through_ which we perceive emotions and overcome the above challenge to an otherwise attractive view. (shrink)

Controversial and provocative, To Be Real is a blueprint for the creation of a new political force.

We consider the current debate between bioconservatives and their opponents—whom we dub bioliberals—about the moral acceptability of human enhancement and the policy implications of moral debates about enhancement. We argue that this debate has reached an impasse, largely because bioconservatives hold that we should honour intuitions about the special value of being human, even if we cannot identify reasons to ground those intuitions. We argue that although intuitions are often a reliable guide to belief and action, there are circumstances in (...) which they are not reliable. Intuitions—including intuitions about enhancement—are subject to various cognitive biases rendering them unreliable in some circumstances. We argue that many bioconservative intuitions about enhancement are examples of such unreliable intuitions. Given this, it is unrealistic of bioconservatives to expect others to rely on their unexamined intuitions. Furthermore, refusing to engage in debates about the reasons and values that underpin their intuitions about enhancement will have the effect of making bioconservative voices less relevant in policy debates about enhancement than they would otherwise be. (shrink)

Games Studies reveals the performative nature of playing a character in a virtual-game-world (Nitsche 2008, p.205; Pearce 2006, p.1; Taylor 2002, p.48). Tbe Player/Character relationship is typically understood in terms of the player’s in-game “presence” (Boellstorff 2008, p.89; Schroeder 2002, p.6). This gives the appearance that living-into a game-world is an all-or- nothing affair: either the player is “present” in the game-world, or they are not. I argue that, in fact, a constitutive phenomenology reveals the Player/Character relationship to be a (...) multi-dimensional matter of empathy. I advance a broadly Schutzian framework, drawing on his 1932 discussions of “face-to-face encounters” and ”historical predecessors,” showing how at- tention to empathy reveals a variety of “presences” that different kinds of Player/Character relationships afford. The central determinants of empathetic affordances which I focus on here are (i) how much players know about a character (especially the character’s past) and (ii) how players learn this information.The purpose of this discussion will be to show that a phenomenological analysis reveals that the relationship between a player and their character is complex, highly variable, and inherently social. Furthermore, it will add to the growing body of scholarship that demonstrates that video games are rich social objects deserving of study. (shrink)

Traditionally, discussions of moral participation – and in particular moral agency – have focused on fully formed human actors. There has been some interest in the development of morality in humans, as well as interest in cultural differences when it comes to moral practices, commitments, and actions. However, until relatively recently, there has been little focus on the possibility that nonhuman animals have any role to play in morality, save being the objects of moral concern. Moreover, when nonhuman cases are (...) considered as evidence of moral agency or subjecthood, there has been an anthropocentric tendency to focus on those behaviors that inform our attributions of moral agency to humans. For example, some argue that the ability to evaluate the principles upon which a moral norm is grounded is required for full moral agency. Certainly, if a moral agent must understand what makes an action right or wrong, then most nonhuman animals would not qualify (and perhaps some humans too). However, if we are to understand the evolution of moral psychology and moral practice, we need to turn our attention to the foundations of full moral agency. We must first pay attention to the more broadly normative practices of other animals. Here, we begin that project by considering evidence that great apes and cetaceans participate in normative practices. (shrink)

Defining the capital vice of sloth (acedia) is a difficult business in Thomas Aquinas and in the Christian tradition of thought from which he draws his account. In this article, I will raise three problems for interpreting Aquinas's account of sloth. They are all related, as are the resolutions to them I will offer. The three problems can be framed as questions: How, on Aquinas's account, can sloth consistently be categorized as, first, a capital vice and, second, a spiritual vice? (...) These two questions lead to a third, namely, how is the condition of sloth possible, given Aquinas's moral psychology and the nature of the will? The resolution of these interpretive issues can help do two things. It can help explain the apparent inconsistency between traditional (ancient and medieval) and contemporary conceptions of this vice, and —if Aquinas's account is right— it can help us diagnose contemporary moral and spiritual maladies that may either go unnoticed or be confused with distinctively modern "virtues" like diligence and industriousness. (shrink)

I argue that the direct perception of emotion (DP) is best conceived in terms of event perception, rather than fact perception or object perception. On neither of these two traditional models can the perception of emotion be as direct as its counterpart in ordinary perception; the proponent of DP must either drop the ‘direct’ claim or embrace a part-whole model of emotion perception and its problems. But our best account of how we perceive events directly can be applied to emotion (...) perception without any loss in directness. Not only this but there are good reasons to think that such a conception better respects both empirical evidence and the phenomenology of emotion perception. (shrink)

Over the course of its history, feminist standpoint theory has encountered a number of problems which reveal divisions among its supporters over certain fundamental philosophical commitments. This chapter sketches a phenomenological account of perception that can begin to address these problems, drawn largely from Maurice Merleau-Ponty’s Phenomenology of Perception. Merleau-Ponty can help us resolve these issues by providing an account of perspectival perception wherein a multiplicity of different perceptual standpoints all nonetheless put us in touch with a single external world, (...) and in which some standpoints may be better than others when it comes to accessing certain features of this world. For Merleau-Ponty, the proliferation of standpoints need not lead us into an unacceptably relativistic framework, as long as we are able to conceive of each of these standpoints as giving whoever occupies it access to some particular aspect of a singular, real, shared world. (shrink)

Heidegger’s engagement with the poet Friedrich Hölderlin often dwells on the issue of temporality. For Heidegger, Hölderlin is the most futural thinker (zukünftigster Denker) whose poetry is necessary for us now and must be wrested from being buried in the past. Heidegger frames his reading of Hölderlin in terms of past, present, and future and, more importantly, describes him as being able to poetize time. This paper examines what it means to poetize time and why Hölderlin’s poetry in particular allows (...) us to understand temporality as the interplay of presence and non-presence. (shrink)

This chapter explores two kinds of testimonial trust, what we call ‘evidential trust’ and ‘non-evidential trust’ with the aim of asking how testimonial trust could provide epistemic reasons for belief. We argue that neither evidential nor non-evidential trust can play a distinctive role in providing evidential reasons for belief, but we tentatively propose that non-evidential trust can in some circumstances provide a novel kind of epistemic reason for belief, a reason of epistemic facilitation. The chapter begins with an extensive discussion (...) of standard accounts of both kinds of trust and criticises especially the standard accounts of non-evidential trust. A new account of non-evidential trust is offered that avoids a number of difficulties that plague the standard accounts by rejecting what we call ‘attitude-liability assumptions’. (shrink)

Open peer commentary on the article “Constructivist Model Building: Empirical Examples From Mathematics Education” by Catherine Ulrich, Erik S. Tillema, Amy J. Hackenberg & Anderson Norton. Upshot: I argue that radical constructivism poses a series of deep methodological constraints on educational research. We focus on the work of Ulrich et al. to illustrate the practical implications of these constraints.

(No abstract is available for this citation).

Feminist standpoint theory is a variety of feminist epistemology that has been active since the 1980s. Its two central tenets are (1) that knowledge is necessarily situated within a socio-political context, and (2) that certain socio-political positions or standpoints are epistemically privileged when it comes to “reveal[ing] the truth of social reality” (Hekman 1997). Over the course of its history, standpoint theory has encountered a number of problems which have revealed divisions among its supporters over certain fundamental philosophical commitments. In (...) this paper, I sketch out a phenomenological account of perception that can begin to address these problems, drawn largely from Maurice Merleau-Ponty’s Phenomenology of Perception. There are two major issues that I believe a Merleau-Pontyan view of perception can help alleviate. One is that there has never been a thorough articulation of a theory of perception underlying standpoint theory’s central claims. This is surprising, since arguments in favor of standpoint theory often emphasize that occupying a certain standpoint enables one to see the world differently (see Hartsock 1983, among others). The other problem is the complex tension between standpoint theory’s two central theses. Positing that knowledge is necessarily situated seems to make it difficult to account for one single reality about which some particular group could be epistemically privileged (Hekman 1997). Merleau-Ponty can help us resolve these issues by providing an account of perspectival perception wherein a multiplicity of different perceptual standpoints all nonetheless put us in touch with a single "external" world. Merleau-Ponty’s account also explains how it could be that some standpoints are better than others when it comes to accessing certain features of this world. For Merleau-Ponty, it is not a problem if each perspective is incomplete, partial, or even apparently conflicting with other perspectives. The proliferation of standpoints need not lead us into an unacceptably relativistic framework, as long as we are able to conceive of each of these standpoints as giving whoever occupies it access to some particular aspect of a singular, real, shared world. (shrink)

The concept of the exception has heavily shaped modern political theory. In modernity, Kierkegaard was one of the first philosophers to propound the exception as a facilitator of metaphysical transcendence. Merging Kierkegaard’s metaphysical exception with early modern political theorist Jean Bodin’s theory of sovereignty, Carl Schmitt introduced sovereignty to metaphysics. He thereby made an early modern concept usable in a post-metaphysical world. This essay carries Schmitt’s appropriation one step further. Drawing on Walter Benjamin’s replacement of transcendental metaphysics with contingent creaturehood, (...) it reintroduces the anti-foundationalist concept of repetition that was implicit in Kierkegaard’s paradigm but which was not made lucid until Benjamin crafted from the Schmittian exception a vision of political life grounded in creaturely existence. -/- . (shrink)

What do we owe each other when we act together? According to normativists about collective action, necessarily something and potentially quite a bit. They contend that collective action inherently involves a special normative status amongst participants, which may, for example, involve mutual obligations to receive the concurrence of the others before leaving. We build on recent empirical work whose results lend plausibility to a normativist account by further investigating the specific package of mutual obligations associated with collective action according to (...) our everyday understanding. However, our results cast doubt on a proposed obligation to seek the permission of co-actors before exiting a collective action, and suggest instead that this obligation is a function of explicit promising. We then discuss how our results pave the path for a new normativism, a theory that neither under- nor overshoots the target given by our common conception of the interpersonal obligations present in collective action.*. (shrink)

Scholars have thoroughly discussed the visual aspects of Foucault’s archaeological and genealogical methods, as well as his own emphasis on how sight functions and what contexts and conditions shape how we see and what we can see. Yet while some of the images and visual devices he uses are frequently discussed, like Las Meninas and the panopticon, his diagrams in The Order of Things have received little attention. Why does Foucault diagram historical ways of thinking? What are we supposed to (...) see and understand through these diagrams? To examine the role of the diagram in Foucault’s archaeological method, this paper provides a close reading of how the classical quadrilateral visualizes the structure, function, content, principles, and underlying assumptions of language and thought. In analyzing the diagram as a way for visualizing history, this paper demonstrates how Foucault enacts a new visual language that emphasizes the contingency of thought. (shrink)

Recent events have revived questions about the circumstances that ought to trigger therapists' duty to warn or protect. There is extensive interstate variation in duty to warn or protect statutes enacted and rulings made in the wake of the California Tarasoff ruling. These duties may be codified in legislative statutes, established in common law through court rulings, or remain unspecified. Furthermore, the duty to warn or protect is not only variable between states but also has been dynamic across time. In (...) this article, we review the implications of this variability and dynamism, focusing on three sets of questions: first, what legal and ethics-related challenges do therapists in each of the three broad categories of states (states that mandate therapists to warn or protect, states that permit therapists to breach confidentiality for warnings but have no mandate, and states that give no guidance) face in handling threats of violence? Second, what training do therapists and other professionals involved in handling violent threats receive, and is this training adequate for the task that these professionals are charged with? Third, how have recent court cases changed the scope of the duty? We conclude by pointing to gaps in the empirical and conceptual scholarship surrounding the duty to warn or protect. (shrink)

This paper interprets von Trier’s Dogville as a suspension of belief that provokes a re-evaluation of contemporary moral values. Reading Dogville through the Stoic concept of phantasms and Nietzsche’s perspectivism, I analyze the plot and visual techniques as revealing how we form, evaluate, and re-evaluate our beliefs based on changing impressions and shifting perspectives. The philosophy of the Stoics and Nietzsche and the visual techniques of Dogville demonstrate that the recognition of the artificiality of appearances serves a moral purpose by (...) forcing us to examine our beliefs more deeply. In this way, von Trier presents film as a powerful art form for suspending and evaluating how we see and understand the world. (shrink)

In this essay I will contend that there is something called holy fear, which expresses love for God. First I distinguish holy fear from certain types of unholy fear and from the type of fear regulated by the virtue of courage. Next, relying on the work of Thomas Aquinas, I consider the roles love and power play in holy and unholy fear and extend his analysis of the passion of fear by analogy to the capital vices. I conclude that this (...) extension illuminates the moral significance of John PaulII’s call not to be afraid and shows how this theme of his pontificate is inextricably linked to another great theme of his teaching, that of love as a gift of oneself. (shrink)

This paper applies Karl Jaspers’ and Martin Heidegger’s accounts of transcendence to their descriptions of Van Gogh’s art. I will contrast Jaspers’ more vertical account of immanent transcendence to Heidegger’s horizontal one. This difference between their separate understandings of transcendence manifests itself in their estimations of the significance of Van Gogh’s art. Using phenomenology to understand Van Gogh’s art in light of immanent transcendence, moreover, illuminates a new understanding of transcendence as the ‘beyond’ that is always already here in the (...) immanent and reveals the ability of an object to point beyond itself. Both of these concepts are at work in Van Gogh’s art as well as modern art in general as the expansion of reality through new sight. Immanent transcendence and Van Gogh’s art are different but interconnected ways of rethinking experience beyond the limits of positivism and the myth of the given. Van Gogh’s art thus embodies a sensible world transformed. In particular, Van Gogh’s landscapes and still life series suggest the inexhaustibility of the things we so often overlook in our everyday experience. (shrink)

Among the most persuasive arguments against hate speech bans was made by Ronald Dworkin, who warned of the threat to political legitimacy posed by laws that deny those subject to them adequ...

This essay uses Arnaldo Momigliano's genealogy of antiquarianism and historiography to propose a new method for engaging the past. Momigliano traced antiquarianism from its advent in ancient Greece and later growth in Rome to its early modern efflorescence, its usurpation by history, and its transformation into anthropology and sociology in late modernity. Antiquarianism performed for Momigliano the work of excavating past archives while infusing historiographical inquiry with a much-needed dose of contingency. This essay aims to advance our understanding of the (...) mutual imbrications of antiquarian methods with modern conceptions of history, while also suggesting how antiquarianism can generate alternatives to historical inquiry. (shrink)

This paper is an exploration of the Thomistic vice of despair, one of two vices opposed to the theological virtue of hope. Aquinas's conception of despair as a vice, and a theological vice in particular, distances him from contemporary use of the term "despair" to describe an emotional state. His account nonetheless yields a compelling psychological portrait of moral degeneration, which I explain via despair's link to its "root," the capital vice of sloth. Cases in which sloth and its offspring (...) vices progress into full-fledged despair raise intersecting issues about whether and how despair might be remediable. I conclude by considering puzzles regarding despair's disordered effects on the intellect and will and weighing three possible means of remedying it. (shrink)

To what extent do aesthetic taste and our interest in the arts constitute who we are? In this paper, we present a series of empirical findings that suggest an Aesthetic Self Effect supporting the claim that our aesthetic engagements are a central component of our identity. Counterfactual changes in aesthetic preferences, for example, moving from liking classical music to liking pop, are perceived as altering us as a person. The Aesthetic Self Effect is as strong as the impact of moral (...) changes, such as altering political partisanship or religious orientation, and significantly stronger than for other categories of taste, such as food preferences. Using a multidimensional scaling technique to map perceived aesthetic similarities among musical genres, we determined that aesthetic distances between genres correlate highly with the perceived difference in identity. Further studies generalize the Aesthetic Self Effect beyond the musical domain: general changes in visual art preferences, for example from more traditional to abstract art, also elicited a strong Self Effect. Exploring the breadth of this effect we also found an Anaesthetic Self Effect. That is, hypothetical changes from aesthetic indifference to caring about music, art, or beauty are judged to have a significant impact on identity. This effect on identity is stronger for aesthetic fields compared to leisure activities, such as hiking or playing video games. Across our studies, the Anaesthetic Self Effect turns out to be stronger than the Aesthetic Self Effect. Taken together, we found evidence for a link between aesthetics and identity: we are aesthetic selves. When our tastes in music and the arts or our aesthetic interests change we take these to be transformative changes. (shrink)

Building on the multivalent meanings of the Arabo- Persian tarjama (‘to interpret’, ‘to translate’, ‘to narrate’), this essay argues for the relevance of Qur’ānic inimitability (i'jāz) to contemporary translation theory. I examine how the translation of Arabic rhetorical theory ('ilm al-balāgha) into Persian inaugurated new trends within the study of literary meaning. Finally, I show how Islamic aesthetics conceptualizes the translatability of literary texts along lines kindred to Walter Benjamin. -/- .

(Awarded the International Society for Intellectual History’s Charles Schmitt Prize) Mīrzā Fatḥ 'Alī Ākhūndzāda’s Letters from Prince Kamāl al-Dawla to the Prince Jalāl al-Dawla (1865) is often read as a Persian attempt to introduce European Enlightenment political thought to modern Iranian society. This essay frames Ākhūndzāda’s text within a broader intellectual tradition. I read Ākhūndzāda as a radical reformer whose intellectual ambition were shaped by prior Persian and Arabic endeavors to map the diversity of religious belief and to critically assess (...) the limits of religion. That Ākhūndzāda’s critique of religion reached further than that of his predecessors is due in part to the influence of the European Enlightenment, but Ākhūndzāda’s form of critical reasoning was also substantially shaped by prior early modern intellectual genealogies. -/- . (shrink)

This essay examines Giambattista Vico’s philology as a contribution to democratic legitimacy. I outline three steps in Vico’s account of the historical and political development of philological knowledge. First, his merger of philosophy and philology, and the effects of that merge on the relative claims of reason and authority. Second, his use of antiquarian knowledge to supersede historicist accounts of change in time and to position the plebian social class as the true arbiters of language. Third, his understanding of philological (...) knowledge as an instrument of political change, and a foundational element in the establishment of democracy. By treating the philological imagination as a tool for bringing about political change, Vico’s plebian philology is radically democratic, and a crucial instrument in the struggle against the elite, from antiquity to the present. -/- . (shrink)

Court cases involving sexual assault and police violence rely heavily on victim testimony. We consider what we call the “Traumatic Untrustworthiness Argument (TUA)” according to which we should be skeptical about victim testimony because people are particularly liable to misremember traumatic events. The TUA is not obviously based in mere distrust of women, people of color, disabled people, poor people, etc. Rather, it seeks to justify skepticism on epistemic and empirical grounds. We consider how the TUA might appeal to the (...) psychology and neuroscience of memory for empirical support. However, we argue that neither support the TUA. (shrink)