Creativity and innovation is very part of human nature (fitrah) which makes human beings different from other beings that are so far found on the planet. The outcome of creativity can be both harmful and beneficial. And most of it depends on the moral standing of those to whom end products of such creativity are available. Islam gives high importance to health and the Muslim civilization that flourished in Bagdad and Spain during the medieval period made original contributions to (...) medical science. The contributions of the scholars of the age were led by religious ethics and spirit in pursuing, using, and creating knowledge. On the other hand, with the advent of modernity, science has received freedom to a greater extent to be ethics-free, neutral, and value- free. This approach has produced new important innovations in medical science and ways of their applications. Some of these innovations and their applications are beneficial and some others are beneficial too if guarded by appropriate ethics, yet some of the applications are questionable. After discussing the ethical repercussions of these innovations and applications, a general ethical framework on the subject is formulated on Islamic guidelines. (shrink)

Innovative practice occurs when a clinician provides something new, untested, or nonstandard to a patient in the course of clinical care, rather than as part of a research study. Commentators have noted that patients engaged in innovative practice are at significant risk of suffering harm, exploitation, or autonomy violations. By creating a pathway for harmful or nonbeneficial interventions to spread within medical practice without being subjected to rigorous scientific evaluation, innovative practice poses similar risks to the wider community of (...) patients and society as a whole. Given these concerns, how should we control and oversee innovative practice, and in particular, how should we coordinate innovative practice and clinical research? In this article, I argue that an ethical approach to overseeing innovative practice must encourage the early transition to rigorous clinical research without delaying or deferring the development of beneficial innovations or violating the autonomy rights of clinicians and their patients. (shrink)

While every health care system stakeholder would seem to be concerned with obtaining the greatest value from a given technology, there is often a disconnect in the perception of value between a technology’s promoters and those responsible for the ultimate decision as to whether or not to pay for it. Adopting an empirical ethics approach, this paper examines how five Canadian medical device manufacturers, via their websites, frame the corporate “value proposition” of their innovation and seek to respond (...) to what they consider the key expectations of their customers. Our analysis shows that the manufacturers’ framing strategies combine claims that relate to valuable socio-technical goals and features such as prevention, efficiency, sense of security, real-time feedback, ease of use and flexibility, all elements that likely resonate with a large spectrum of health care system stakeholders. The websites do not describe, however, how the innovations may impact health care delivery and tend to obfuscate the decisional trade-offs these innovations represent from a health care system perspective. Such framing strategies, we argue, tend to bolster physicians’ and patients’ expectations and provide a large set of stakeholders with powerful rhetorical tools that may influence the health policy arena. Because these strategies are difficult to counter given the paucity of evidence and its limited use in policymaking, establishing sound collective health care priorities will require solid critiques of how certain kinds of medical devices may provide a better (i.e., more valuable) response to health care needs when compared to others. (shrink)

Results indicate substantial improvements in efficiency, accuracy, and personalized care, but also highlight the challenges of data privacy, ethical considerations, and system scalability. By providing a structured analysis, this research contributes insights into optimizing generative AI deployments for both banking and healthcare, ensuring a balance between innovation and risk management. The study concludes with recommendations for future research directions, including advanced model training, ethical guidelines, and enhanced privacy measures. These insights aim to inform practitioners on the benefits of generative (...) AI, ensuring sustainable integration into banking and healthcare ecosystems. (shrink)

This article suggests different approaches to the definition of the nature, types, and component elements of safety culture (SC) in the organization; given the possible method of evaluation; formulated the concept of professional safety culture by taking into account the features of the medical industry; suggested innovative ways to implement the SC and strengthen it to improve the efficiency of hospitals. -/- Запропоновано окремі підходи до трактування сутності, видів і складових елементів культури безпеки (КБ) в організації; надано можливий метод (...) оцінки; сформульовано поняття професійної культури безпеки з урахуванням особливостей медичної галузі; запропоновано інноваційні шляхи впровадження КБ і її зміцнення для підвищення ефективності діяльності медичного закладу. (shrink)

Innovative practice involves medical interventions that deviate from standard practice in significant ways. For many patients, innovative practice offers the best chance of successful treatment. Because little is known about most innovative treatments, clinicians who engage in innovative practice might consider including extra procedures, such as scans or blood draws, to gather information about the innovation. Such information-gathering interventions can yield valuable information for modifying the innovation to benefit future patients and for designing scientific studies of the (...) innovation. However, existing guidelines do not say when or whether it is appropriate to add potentially risky information-gathering interventions for these purposes. As a result, clinicians may assume that information-gathering interventions are ethically inappropriate and should not be used in innovative practice. This assumption can lead to seriously negative consequences, such as increasing the likelihood that harmful or ineffective innovations will be adopted and creating new barriers to the development of genuinely beneficial treatments. We argue that health care institutions need to promote the responsible use of information-gathering interventions as an adjunct to innovative practice, and that these interventions are not clinical research and should not be subject to research oversight. (shrink)

Introduction In 2013, Dr. J. Muizelaar and Dr. R. Schrot, two neurosurgeons at the University of California Davis Medical Center (UCDMC), were found guilty of research misconduct due to failure to comply with institutional policies as well as Food and Drug Administration (FDA) regulations governing human subjects research. At issue here, however, is the difference between research and innovative therapy in the clinical setting of patient care where clinical judgment is reasonably to be privileged. Methods The UCDMC investigative document (...) is reviewed along with standard literature on clinical ethics and clinical data about glioblastoma multiforme (GBM) cancer. Results In this paper I argue that, by tendentiously focusing on policies, regulations, and procedures governing human subjects research, the UCDMC investigation failed to account for the centrality of clinical judgment and clinical ethics pertinent to judicious review of this matter, especially given the unique clinical context of terminally ill patients having exhausted standard care treatment options for glioblastoma multiforme (GBM) cancer. Conclusions The UCDMC investigation raises serious problems for clinicians who are engaged in innovative therapy in the clinical setting, requiring a regulatory framework separate from the normal Institutional Review Board (IRB) process. (shrink)

The need for innovative development of healthcare institutions is determined by the necessity to increase the efficiency of organizational processes based on the formation of new models of cooperation, which will make it possible to get access to new technologies and knowledge. The goal of the study is to determine the parameters of the impact of innovative open cooperation strategy and the strategy of innovative closed cooperation of healthcare institutions on the effectiveness of their organizational structure in the context of (...) dissemination and the use of knowledge. Simulation modeling was applied to generate the most effective organizational management structure in the context of innovative cooperation and knowledge exchange within the organizational processes “Inside-out” and “Inside-in”. It is substantiated that the strategies of innovative cooperation “Open Innovation/Closed Innovation” have a significant impact on the organizational structure of management of healthcare institutions in terms of the “degree of centralization” (Dci), “degree of mediation” (Dii), and “degree of centralization of powers” (Dpi). The values of the selected criteria range from 25,52% to 61,50% in the case of Dii, and from 34,53% to 52,63% in the case of Dci, which indicates a higher efficiency of organizational knowledge exchange processes in healthcare institutions, which adhere to the Open Innovation strategy of innovative cooperation. Therefore, there are significant differences in the effectiveness of the management’s organizational structure depending on the degree of openness of innovative cooperation of healthcare institutions. The strategy of innovative openness allows increasing the number and quality of connections in the context of knowledge exchange between the subjects (actors, agents) of the organizational structure (in a broad sense, considering internal and external levels of externality) of healthcare institutions, regardless of the distance between them and the level of similarity. (shrink)

One of the Belmont Report’s most important contributions was the clear and serviceable distinction it drew between standard medical practice and biomedical research. A less well-known achievement of the Report was its conceptualization of innovative practice, a type of medical practice that is often mistaken for research because it is new, untested, or experimental. Although the discussion of innovative practice in Belmont is brief and somewhat cryptic, this does not reflect the significant progress its authors made in understanding (...) innovative practice and the distinctive ethical issues it raises. This article explores the history and broader context of Belmont’s conception of innovative practice, its strengths and weaknesses, and its contemporary relevance for scholars working in bioethics and health policy. While this conception of innovative practice deserves our attention, it is inherently limited in some important ways. (shrink)

To evaluate an innovative sonopelvimetry method for early prediction of obstructed labour. Methods: A prospective study was conducted in two centers.GPS-based sonopelvimetry, laborProTM (Trig Medical Inc., Yoqneam Ilit, Israel) devise, was used prior to labour in nulliparous women at 39 - 42 weeks gestation remote from labor. Maternal pelvic parameters, including inter-iliac transverse diameter, obstetric conjugate and interspinous diameter were evaluated. Fetal parameters included head station, biparietal diameter and occipitofrontal diameter. Data on delivery and outcome were collected from the (...) electronic files. Results: The innovative use of sonopelvimetry was applied to 154 consecutive women, none of the participants complained of discomfort or complications observed. The mean time of examination was 15 + 2 minutes. Mean time of examination to delivery interval was 4.8 days (range 0 - 16 days). Small interspinous diameter and high head station were the best predictors for obstructed labour. Analysis indicated 87% sensitivity and 61% specificity for birth weight fetal head station and ISD combined in predicting obstructed labour with an area under the curve of 0.77. Conclusions: Our results indicate that GPS-based sonopelvimetry combined with fetal estimated weight is a valuable tool in the risk assessment of obstructed labour. Parameters obtained by sonopelvimetry combined with birth weight may be useful. (shrink)

The mind is not structured anatomically, as emphasized by modern pathology. Instead, it is expanded as a whole in a subtle form behind the physical body. In the Indian system of medical philosophy, the mind is considered as the astral nerves made third body, which identified as the ‘Manomaya-sharira’ (subconscious mind). The mind is composed of millions of astralnadis, through which Pranic-energies circulate freely into the astral anatomy of mind. Seven-chakras are found parallel to the spine, serving as the (...) major seven innovation centres in the body. These Chakras facilitate the connection of the mind with the seven dimensions of the inner world. From these dimensions the Pranic-energies including Sattva, Raja, Tama are exported to the mind and its Nadi-tantras, influencing both the outer and inner subconscious minds. Subsequently, these elements, viz., Sattva, Raja and Tama are thrown from the mind to the outer world through the seven sense organs, manifesting as either constructive or destructive activities. Thus the mind exists due to ‘Prana’, (energy of Omkara) which increases through deeper meditation, sound sleep, and breathing exercises (O2). The positional behaviour of the mind shifts according to the physical and mental temperament, namely Triguna and Tridosha, or Panchavikara. The negative energy (Tama-guna) of the fourth dimension enters the astral Nadis-system of the mind via the interspace of the solar plexus, which crushes the mind’s structures, and consequently, all the Chakras are corrupted and the Nadis are blocked, so it generates a break in the circulation of ‘Prana’ into the Nadis. As a result, many socio-economic challenges and psychosomatic disorders occur. (shrink)

Additionally, privacy and security concerns surrounding medical data are addressed by ensuring compliance with stringent data protection standards such as HIPAA and GDPR, thereby ensuring users that their medical information is handled securely and confidentially. The solution aims to improve healthcare accessibility, reduce delays in diagnosis, and provide users with greater control over their health management. This report outlines the chatbot’s design, the integration of image processing techniques, the use of machine learning models for disease identification, and the (...) importance of data privacy in healthcare applications. (shrink)

The recent progression in AI, nanomedicine and robotics have increased concerns about ethics, policy and law. The increasing complexity and hybrid nature of AI and nanotechnologies impact the functionality of “law in action” which can lead to legal uncertainty and ultimately to a public distrust. There is an immediate need of collaboration between Central Asian biomedical scientists, AI engineers and academic lawyers for the harmonization of AI, nanomedicines and robotics in Central Asian legal system.

A self-fulfilling prophecy in neuroprognostication occurs when a patient in coma is predicted to have a poor outcome, and life-sustaining treatment is withdrawn on the basis of that prediction, thus directly bringing about a poor outcome for that patient. In contrast to the predominant emphasis in the bioethics literature, we look beyond the moral issues raised by the possibility that an erroneous prediction might lead to the death of a patient who otherwise would have lived. Instead, we focus on the (...) problematic epistemic consequences of neuroprognostic SFPs in settings where research and practice intersect. When this sort of SFP occurs, the problem is that physicians and researchers are never in a position to notice whether their original prognosis was correct or incorrect, since the patient dies anyway. Thus, SFPs keep us from discerning false positives from true positives, inhibiting proper assessment of novel prognostic tests. This epistemic problem of SFPs thus impedes learning, but ethical obligations of patient care make it difficult to avoid SFPs. We then show how the impediment to catching false positive indicators of poor outcome distorts research on novel techniques for neuroprognostication, allowing biases to persist in prognostic tests. We finally highlight a particular risk that a precautionary bias towards early withdrawal of life-sustaining treatment may be amplified. We conclude with guidelines about how researchers can mitigate the epistemic problems of SFPs, to achieve more responsible innovation of neuroprognostication for patients in coma. (shrink)

Reflection is widely acknowledged to play a crucial role in enhancing the competence of medical professionals. Developed countries have given importance to implementing reflective practices for professional development. In developing countries, reflective practices are not given much importance as a tool for professional growth. This article aims to uncover the existing practices of reflection and the challenges faced by medical professionals working at a government hospital in Nepal. It also promotes the practice of reflection to improve daily professional (...) practice. This article aims to uncover the existing practices of reflection and the challenges faced by medical professionals working at a government hospital in Nepal. This qualitative study utilized Narrative Inquiry as the research method and conducted semi-structured, in-depth interviews with two medical professionals selected through purposive sampling followed by content analysis of the collected data. The study was based on the theories of social constructivism and transformative learning. After analyzing the data, three significant themes emerged: empathizing through reflection, change in practice through reflection, and barriers to reflective practices. The study identified several barriers to reflective practices, including a negative attitude, sociocultural contexts, and a lack of support from the medical community. It is crucial to encourage self-reflection for medical professionals to enhance their professional growth and promote lifelong learning. This study provides valuable insights into the significance of reflective practices in the professional development of medical personnel, particularly in developing countries. (shrink)

Abstract: The integration of artificial intelligence (AI) into drug discovery is revolutionizing the pharmaceutical industry by accelerating the development of novel therapeutics. AI-powered tools enable researchers to process vast datasets, identify drug candidates, and predict their efficacy and safety with unprecedented speed and accuracy. This paper explores the transformative impact of AI on drug discovery, highlighting key advancements in machine learning algorithms, deep learning, and predictive modeling. Additionally, it addresses the challenges associated with AI implementation, including data quality, regulatory hurdles, (...) and ethical considerations. By analyzing case studies of AI-driven pharmaceutical breakthroughs, this paper underscores AI's potential to streamline drug development, reduce costs, and address unmet medical needs. The future of drug discovery is poised to shift dramatically as AI continues to advance, offering promising solutions for improving human health. (shrink)

The article presents the advantages and limitations of adaptive clinical trials for assessing the effectiveness of medical interventions and specifies the conditions that contributed to their development and implementation in clinical practice. I advance two arguments by discussing different cases of adaptive trials. The normative argument is that responsible adaptation should be taken seriously as a new way of doing clinical research insofar as a valid justification, sufficient understanding, and adequate operational conditions are provided. The second argument is historical. (...) The development of adaptive trials can be related to lessons learned from research in cases of urgency and to the decades-long efforts to end the productivity crisis of pharmaceutical research, which led to the emergence of translational, personalized, and, recently, precision medicine movements. (shrink)

The rapid advancement of digital health innovation, including Artificial Intelligence (AI), is transforming healthcare. The growing role the European Union (EU) plays in regulating the use of AI in healthcare renders national laws insufficient to safeguard patients from unique AIrelated risks. This underscores the urgent need for the recognition of a canon of patients' rights in the scope of EU law. This paper proposes the blueprint for an EU Charter for Digital Patients' Rights, consolidating and adapting existing rights for (...) patients to address these specific challenges. Traditional patients' rights such as the right to privacy and the right to informed consent are interpreted in light of the challenges posed by AI. It also proposes novel rights for patients, such as the right not to be subject to automated medical decision-making and the right to meaningful human contact. This paper highlights the EU's central role in protecting patients' rights and outlines strategies for effective implementation. This comprehensive approach aims to address the current shortcomings and enhance the legal framework governing digital health in Europe. (shrink)

Braun explores the use of digital twin technology in medicine with a particular emphasis on the question of how such simulations can represent a person.1 In defining some first conditions for ethically justifiable forms of representation of digital twins, he argues that digital twins do not threaten an embodied person, as long as that person retains control over their simulated representation via dynamic consent, and ideally with the option to choose both form and usage of the simulation. His thoughtful elaboration (...) provides insight into the challenges inherent in interactions between a person and their digital twin, emphasising the modes of control required to respect personal modes of freedom. This individual-centric approach to the question of representation leaves out the important ethical consideration of ensuring that all, not merely some, can be represented. Braun describes dynamic consent as a necessary mode of control, arguing that where a person is unable to give consent, ‘such simulations threaten to become illegitimate representations. They would then shift the kind of interaction from representation to illegitimate forms of prediction or surveillance and thereby could lead to infringements to individual modes of freedom.’ Consequently, the implementation of digital twin technology in healthcare would seem to exclude the most vulnerable members of society from participation in and benefiting from medical innovation, …. (shrink)

For the past three years, Coronavirus-19 (Covid-19) has become one of the major global health problems. Unlike any previous virus in the past decades, Covid-19 has shown its unprecedented spreading speed, infection rate, fatality rate, etc. Under this urgent disease outbursting event, scientists around the globe, through the myriad of research and experiments, successfully developed effective vaccines. However, like many other medical innovations, Covid-19 vaccines are categorized as intellectual properties and a scarce resource. As a consequence, the citizens of (...) developed and developing countries face an imbalanced distribution of affordable vaccines. The formation of this issue is not only due to manufacturing, transportation, and other infrastructures, but also strongly correlated with aspects in the legal field, such as intellectual property rights (IPRs). With a humane common sense of vaccination many people, through comparative research method, this article aims to discuss the conflicts between the global crisis of Force Majeure and the interests of certain countries or corporations, possible solutions to resolve this conflict, and future coping strategies that ought to be published. (shrink)

The current humanitarian use of drones is focused on two applications: disaster mapping and medical supply delivery. In response to the growing interest in drone deployment in the aid sector, we sought to develop a resource to support value sensitivity in humanitarian drone activities. Following a bottom-up approach encompassing a comprehensive literature review, two empirical studies, a review of guidance documents, and consultations with experts, this work illuminates the nature and scope of ethical challenges encountered by humanitarian organizations embarking (...) upon innovation programmes. The Framework for the Ethics Assessment of Humanitarian Drones (FEAHD) identifies five values and five key questions related to ethical considerations along the decision chain of humanitarian drone activities. It fills a gap between high-level, principle-based guidance related to humanitarian innovation, and detailed operation-oriented checklists for projects involving the use of drones. In this way, the FEAHD contributes to support value sensitivity in the humanitarian use of drones. (shrink)

This Viewpoint analyzes policies for covering GLP-1 receptor agonist drugs for obesity treatment across 13 high-income countries. It identifies four key lessons for developing coverage policies: 1) using up-to-date cost-effectiveness analyses that incorporate new evidence of benefits, 2) negotiating lower prices while preserving innovation incentives, 3) prioritizing coverage for specific populations rather than issuing blanket denials, and 4) treating obesity medications similarly to high-cost drugs for other conditions. It argues that blanket coverage denials are unethical and that countries should (...) implement targeted coverage policies that maximize benefits while managing costs. (shrink)

In this chapter, we analyze the relationship between Kondratieff waves and major technological revolutions on the basis of the theory of production principles and production revolutions, and offer some forecasts about the features of the Sixth Kondratieff Wave/the Fourth Industrial Revolution. We show that the technological breakthrough of the Sixth Kondratieff Wave may be interpreted as both the Fourth Industrial Revolution and as the final phase of the Cybernetic Revolution. We assume that the sixth K-wave in the 2030s and 2040s (...) will merge with the final phase of the Cybernetic Revolution (which we call a phase of selfregulating systems). This period will be characterized by the breakthrough in medical technologies which will be capable of combining a number of other technologies into a single system of new and innovative technologies (we denote this system as a system of MANBRIC-technologies—i.e. medical, additive, nano-, bio-, robo-, info-, and cogno-technologies). (shrink)

The issue of safety culture is one of the most important in a modern medical facility because any problems during the provision of services may lead to irreversible consequences. Not only the patient may suffer, but the doctor who assisted. Unfortunately, very little attention to this issue is paid in Ukraine. Based on this, we can say that the topic is relevant and requires studying. -/- The purpose of writing this article is the analysis of the ways of forming (...) professional safety culture in clinical medicine. The methods by which we carried out scientific research are observation, analysis, evaluation, comparison, generalization. -/- The work examined interpretation of the term "safety culture", types of innovation in which it belongs and the main methods of its creation in the medical field. -/- Safety culture in the medical field involves the right of all health care workers to use measures to prevent actions that can harm a patient or a colleague. Different approaches were considered in the interpretation of the term "safety culture" and we proposed our own: safety culture is a system of values, objectives, knowledge and skills, rules and procedures, convictions shared by representatives of a certain medical profession and supported by patients, creating a favourable working climate, atmosphere of trust and becoming an efficient tool for achieving the goals of the organization. -/- The main components of the safety culture were defined: responsibilities of managers, communication, performance, resources of safety, trust, the degree of job satisfaction, etc. Based on several studies, it was found that no country has a perfect medical system. Every system should be improved. -/- We proposed measures to fix the situation with the safety culture in health care facilities. The correct management of safety can eliminate or fix many medical errors. That is why the need for a clear program of implementation, execution and control of SC in the medical establishment is necessary. -/- Scientific novelty of this work lies in the interpretation of the term "safety culture" at medical institutions and in determining major steps towards its creation. Practical value of the work is the opportunity to implement these steps in medical institutions for improvement of the safety culture and, therefore, to reduce the risk of bad accidents during treatment. -/- Further research can address safety culture management in medical institutions on the examples from the experience of countries with effective systems of health care. (shrink)

Driven by technological innovations, newborn screening (NBS) panels have been expanded and the development of genomic NBS pilot programs is rapidly progressing. Decisions on disease selection for NBS are still based on the Wilson and Jungner (WJ) criteria published in 1968. Despite this uniform reference, interpretation of the WJ criteria and actual disease selection for NBS programs are highly variable. A systematic literature search [PubMED search “Wilson” AND “Jungner”; last search 16.07.22] was performed to evaluate the applicability of the WJ (...) criteria for current and future NBS programs and the need for adaptation. By at least two reviewers, 105 publications (systematic literature search, N = 77; manual search, N = 28) were screened for relevant content and, finally, 38 publications were evaluated. Limited by the study design of qualitative text analysis, no statistical evaluation was performed, but a structured collection of reported aspects of criticism and proposed improvements was instead collated. This revealed a set of general limitations of the WJ criteria, such as imprecise terminology, lack of measurability and objectivity, missing pediatric focus, and absent guidance on program management. Furthermore, it unraveled specific aspects of criticism on clinical, diagnostic, therapeutic, and economical aspects. A major obstacle was found to be the incompletely understood natural history and phenotypic diversity of rare diseases prior to NBS implementation, resulting in uncertainty about case definition, risk stratification, and indications for treatment. This gap could be closed through the systematic collection and evaluation of real-world evidence on the quality, safety, and (cost-)effectiveness of NBS, as well as the long-term benefits experienced by screened individuals. An integrated NBS public health program that is designed to continuously learn would fulfil these requirements, and a multi-dimensional framework for future NBS programs integrating medical, ethical, legal, and societal perspectives is overdue. (shrink)

The rapid adoption of digital technologies in healthcare has revolutionized patient care, enabling seamless data sharing, remote consultations, and enhanced medical record management. However, this digital transformation has also introduced significant challenges to network security and data protection. Healthcare institutions face a dual challenge: ensuring uninterrupted connectivity for critical operations and safeguarding sensitive patient information from cyber threats. These challenges are exacerbated by the increased use of interconnected devices, electronic health records (EHRs), and cloud-based solutions, which, while enhancing efficiency, (...) expand the attack surface for malicious actors. This research focuses on addressing the pressing need for robust network security in healthcare institutions. It examines the unique vulnerabilities of healthcare networks, including the risks posed by outdated infrastructure, insufficient encryption protocols, and the lack of standardized security practices across systems. The paper highlights the critical role of advanced cybersecurity frameworks, such as zero-trust architectures and realtime threat detection systems, in mitigating risks. Additionally, it explores the integration of artificial intelligence (AI) and machine learning (ML) in enhancing the predictive capabilities of security tools, enabling institutions to proactively identify and neutralize potential threats. Connectivity remains a cornerstone of modern healthcare operations, facilitating collaboration among healthcare providers and ensuring timely access to patient data. However, maintaining connectivity without compromising security is a complex task. This research delves into strategies for achieving this balance, such as implementing secure Virtual Private Networks (VPNs), multi-factor authentication (MFA), and end-to-end encryption. It also emphasizes the importance of regular network assessments, employee training programs, and the adoption of compliance standards like HIPAA to ensure a secure and resilient network environment. The study includes case analyses of healthcare institutions that successfully navigated cybersecurity challenges, providing actionable insights into effective practices and lessons learned. These examples underscore the importance of integrating technological solutions with a culture of security awareness, emphasizing collaboration between IT professionals and medical staff. As cyber threats continue to evolve, healthcare institutions must remain vigilant and adaptive, embracing innovative solutions to safeguard their networks and protect patient data. This paper contributes to the broader discourse on cybersecurity in healthcare by proposing a comprehensive approach that addresses connectivity and data protection challenges while fostering operational efficiency. By prioritizing network security, healthcare institutions can build trust with patients, comply with regulatory requirements, and ensure the uninterrupted delivery of quality care. This research provides a roadmap for healthcare organizations seeking to strengthen their cybersecurity posture, highlighting the necessity of adopting a proactive, multi-layered approach to combat emerging threats. It calls for continuous investment in advanced technologies and emphasizes the role of collaboration among stakeholders to create a secure and connected healthcare ecosystem. (shrink)

Psychedelics are currently being studied intensively for the treatment of various psychiatric disorders. Ayahuasca, a plant-based extract originating from the Amazonian area, is traditionally consumed in ritualistic group events. The related indigenous traditions date back hundreds of years and have amassed vast amounts of knowledge on the therapeutic use of psychedelic and non-psychedelic plant-based substances. -/- These traditions require a prospective ceremony facilitator to undergo years of intensive training to acquire knowledge, mental power or self-confidence, stability, sensitivity, intuitive treatment outcome (...) prediction skills, musical skills, and sufficient physical strength. These qualities of a facilitator, in the presence of integrity and love, largely determine treatment outcomes. -/- In Europe, predominantly in the first decade of the 2000s and in the early 2010s, some individuals began building connections with diverse indigenous groups and syncretic churches of the Amazonia in an attempt to find cures for their treatment-resistant psychiatric conditions. Small circles of other patients in need of similar treatment formed around them. This led to the formation of decentralized, diverse local ceremony cultures that either followed the principles of the traditional lineages of their origin or synthesized various influences. -/- These unofficial ceremony contexts appeared to complement official healthcare systems, offering efficient methods unavailable in the medical context and correcting the consequences of medical malpractice and neglect. These ceremony contexts appeared highly communal, were largely based on volunteering, and contained mechanisms for self-correcting possible emerging issues. They seemed to function as systems for collecting, preserving, storing, and distributing knowledge of psychedelic therapy methods; in other words, systems for knowledge base building and innovation. -/- doi: 10.13140/RG.2.2.27385.85602. (shrink)

New developments in biotechnology radically alter our relationship with our bodies. Body tissues can now be used for commercial purposes, while external objects, such as pacemakers, can become part of the body. Property in the Body: Feminist Perspectives transcends the everyday responses to such developments, suggesting that what we most fear is the feminisation of the body. We fear our bodies are becoming objects of property, turning us into things rather than persons. This book evaluates how well-grounded this fear is, (...) and suggests innovative models of regulating what has been called 'the new Gold Rush' in human tissue. This is an up-to-date and wide-ranging synthesis of market developments in body tissue, bringing together bioethics, feminist theory and lessons from countries that have resisted commercialisation of the body, in a theoretically sophisticated and practically significant approach. (shrink)

The rapid advancement of artificial intelligence (AI) and machine learning (ML) has led to significant innovations in the healthcare sector. One such development is AI-powered healthcare chatbots, which assist patients and medical professionals by providing medical guidance, symptom assessment, and appointment scheduling. This paper presents the design and implementation of an AI healthcare chatbot using machine learning techniques. The chatbot leverages natural language processing (NLP) and deep learning models to understand and respond to user queries effectively. Experimental results (...) demonstrate the chatbot's efficiency in delivering accurate and context-aware medical information. (shrink)

This project has been supported by the Australian Government through the Australian Research Council (project number CS170100008); the Department of Industry, Innovation and Science; and the Department of Prime Minister and Cabinet. ACOLA collaborates with the Australian Academy of Health and Medical Sciences and the New Zealand Royal Society Te Apārangi to deliver the interdisciplinary Horizon Scanning reports to government. The aims of the project which produced this report are: 1. Examine the transformative role that artificial intelligence may (...) play in different sectors of the economy, including the opportunities, risks and challenges that advancement presents. 2. Examine the ethical, legal and social considerations and frameworks required to enable and support broad development and uptake of artificial intelligence. 3. Assess the future education, skills and infrastructure requirements to manage workforce transition and support thriving and internationally competitive artificial intelligence industries. (shrink)

Generative AI is reshaping sectors like banking and healthcare by enabling innovative applications such as personalized service offerings, predictive analytics, and automated content generation. In banking, generative AI drives customer engagement through tailored financial advice, fraud detection, and streamlined customer service. Meanwhile, in healthcare, it enhances medical imaging analysis, drug discovery, and patient diagnostics, significantly impacting patient care and operational efficiency. This paper presents an experimental study examining the implementation and effectiveness of generative AI in these sectors.

The foundational gesture of New Materialism and Speculative Realism dismisses vast swaths of past philosophy and theory in order to signify their own avant-garde status. The violence of this gesture, which tries to corral difference within past texts in order to feign its own purity, can be considered as a theoretical quarantine. Examples of medical and spiritual quarantine, the 2014 ebola epidemic and Jesus’ temptation, are analyzed to show that the figure is inherently compromised – the harder one fights (...) to keep the other away, the more one becomes inseparable from it. Derrida's reflections on the reactions against deconstruction show that this desire for progress is always inherently conservative; Meillassoux and Jane Bennett are considered as contemporary examples. A deconstruction of corralation and the academico-capitalist forces driving these ‘innovations’ might open us to reading the never-simply-past text, and to the possibility of the event. (shrink)

Andrea Bidoli argues that ectogestation could be seen as an emancipatory intervention for women. Specifically, she claims that ectogestation would create unique conditions to reevaluate one’s reproductive preference, address certain specific negative social implications of gestation and childbirth, and that it is unfair to hold ectogestation to a higher standard than other innovations such as modern contraceptives and non-medical egg freezing. In this commentary, I claim that Bidoli—like so many others—unjustly bypasses men and their reproductive desires. For a long (...) time, the discussion of the ethics of ectogenesis has focused on women and their reproductive liberation. However, since in many countries, an increasing number of men in reproductive age face difficulties in finding a partner and lack access to other forms of assisted reproduction, it is men who need ectogestation the most. (shrink)

Abstract: The convergence of nanotechnology and artificial intelligence (AI) represents a transformative frontier in modern science, with the potential to revolutionize multiple industries, particularly healthcare. Nanotechnology enables the manipulation of matter at the atomic and molecular scale, while AI offers sophisticated data analysis, pattern recognition, and decision-making capabilities. This paper explores the synergies between these two fields, focusing on their impact on medical diagnostics, targeted drug delivery, and personalized treatments. By leveraging AI's predictive power and nanotechnology's precision, healthcare can (...) achieve unprecedented levels of accuracy in disease detection and treatment, leading to improved patient outcomes. Beyond healthcare, this convergence extends to environmental monitoring, smart materials, and manufacturing, offering solutions to some of the world’s most pressing challenges. The paper also discusses the ethical considerations and potential risks of integrating AI with nanotechnology, emphasizing the need for responsible innovation. Together, AI and nanotechnology hold the promise of reshaping industries and improving quality of life on a global . (shrink)

The conjunction of wireless computing, ubiquitous Internet access, and the miniaturisation of sensors have opened the door for technological applications that can monitor health and well-being outside of formal healthcare systems. The health-related Internet of Things (H-IoT) increasingly plays a key role in health management by providing real-time tele-monitoring of patients, testing of treatments, actuation of medical devices, and fitness and well-being monitoring. Given its numerous applications and proposed benefits, adoption by medical and social care institutions and consumers (...) may be rapid. However, a host of ethical concerns are also raised that must be addressed. The inherent sensitivity of health-related data being generated and latent risks of Internet-enabled devices pose serious challenges. Users, already in a vulnerable position as patients, face a seemingly impossible task to retain control over their data due to the scale, scope and complexity of systems that create, aggregate, and analyse personal health data. In response, the H-IoT must be designed to be technologically robust and scientifically reliable, while also remaining ethically responsible, trustworthy, and respectful of user rights and interests. To assist developers of the H-IoT, this paper describes nine principles and nine guidelines for ethical design of H-IoT devices and data protocols. (shrink)

Applying Modern Monetary Theory to the Philippines: Achieving Economic Balance Through Natural Laws -/- Introduction -/- The Philippines faces persistent economic challenges, including slow GDP growth, high income inequality, inflationary pressures, and overpopulation. Traditional economic policies often focus on austerity, borrowing limits, and foreign investments, but these approaches fail to address the root causes of economic imbalance. -/- Modern Monetary Theory (MMT) offers an alternative by allowing the government to issue money to finance public spending without relying on foreign debt (...) or excessive taxation. However, to prevent inflation and ensure long-term stability, government spending must be directed toward productive investments. This aligns with my universal formula, which is based on the universal law of balance in nature—ensuring that all systems, including economic ones, function without defects. -/- By integrating MMT with GDP growth, GDP per capita, the Gini coefficient (income equality), population regulation, and good governance, the Philippines can achieve sustainable economic progress while maintaining balance. -/- The Role of a Good and Non-Corrupt Government in Implementing MMT -/- MMT gives governments the power to create money, making it an incredibly powerful tool—but also a dangerous one if misused. A corrupt government can misallocate funds, cause hyperinflation, and worsen inequality. Therefore, strong leadership, transparency, and accountability are essential for MMT to work. -/- Eliminating corruption ensures that newly created money is invested in productive sectors rather than being stolen or wasted. -/- Strict financial oversight and independent institutions must monitor government spending. -/- A well-structured economic plan, free from political interests, must be followed to ensure MMT benefits all Filipinos, not just the elite. -/- If MMT is implemented by a corrupt government, it will only lead to inflation, economic collapse, and further inequality. The law of karma teaches that every action has consequences—if government spending is abused, the entire economy will suffer. -/- Using MMT to Increase the Philippines’ GDP Without Inflation -/- 1. Infrastructure Development -/- The Philippines suffers from poor infrastructure, leading to high transportation and electricity costs. Government investment in roads, ports, and energy projects would improve economic efficiency, reducing production costs and increasing business competitiveness. -/- The government can print money under MMT to fund major infrastructure projects, provided the projects enhance productivity. -/- Improved infrastructure will increase GDP by facilitating trade, reducing delays, and boosting industrial growth. -/- With proper planning, this investment will not cause inflation because it adds real value to the economy. -/- However, for infrastructure spending to be effective, the government must eliminate corruption in project implementation. Ghost projects, overpricing, and political kickbacks will waste public money and increase inflation without creating real economic value. -/- 2. Investing in Renewable Energy -/- The Philippines relies heavily on imported fossil fuels, making it vulnerable to price fluctuations. A shift toward solar, wind, and geothermal energy would: -/- Reduce long-term electricity costs, helping businesses expand without raising prices. -/- Make the country energy independent, lowering the need for foreign currency reserves. -/- Increase GDP by creating green energy jobs and technological innovations. -/- A good government will prioritize long-term energy security over short-term political interests. Corrupt officials, however, may block renewable energy projects in favor of profit-driven deals with fossil fuel industries, preventing the country from achieving energy independence. -/- 3. Expanding Manufacturing and Industrialization -/- The Philippine economy is heavily dependent on services (such as BPOs) and overseas remittances. To create long-term stability, the country must expand its manufacturing sector. -/- Government spending should prioritize local industries, such as electronics, semiconductors, and agribusiness processing. -/- Subsidies and incentives should be given to businesses that create jobs and produce high-value goods. -/- Export-oriented manufacturing would increase GDP while keeping money circulation within productive sectors, preventing inflation. -/- A corrupt government, however, may award subsidies and contracts based on political favors rather than economic merit, leading to inefficiency and wasted resources. A good and competent government will ensure that industrial policies are based on merit, efficiency, and long-term economic benefits. -/- 4. Research, Innovation, and Digital Transformation -/- Government investment in science, technology, and artificial intelligence (AI) would drive sustainable economic growth. -/- A national AI and automation strategy can improve industries such as agriculture, logistics, and healthcare, leading to higher GDP. -/- Government-funded research and technology parks can support Filipino startups and entrepreneurs. -/- This will help the country move from a consumer-driven economy to a technology and knowledge-based economy, increasing long-term wealth. -/- Without strong governance and anti-corruption measures, however, research funding may be misused, misallocated, or given to unqualified individuals. The universal law of balance requires that public resources be managed efficiently and fairly to maximize their benefits. -/- GDP Per Capita: Ensuring Growth Benefits Every Filipino -/- While GDP growth is important, it must translate to real improvements in people’s lives. A high GDP with a rapidly growing population leads to a lower GDP per capita, keeping the majority poor. -/- Government policies must regulate population growth through education and family planning. -/- Higher GDP per capita ensures that public investments in healthcare, education, and housing can meet the needs of citizens. -/- A well-balanced population ensures that economic growth does not lead to overconsumption of resources. -/- The Gini Coefficient: Reducing Income Inequality in the Philippines -/- The Philippines has one of the highest income inequality rates in Southeast Asia. The Gini coefficient reveals that wealth is concentrated in the hands of a few, while many struggle to survive. -/- MMT can be used to: -/- Fund free quality education and vocational training, allowing Filipinos to get better-paying jobs. -/- Provide universal healthcare, ensuring that people are not trapped in poverty due to medical expenses. -/- Invest in affordable housing and social safety nets for vulnerable populations. -/- Without addressing inequality, economic growth will only benefit the elite, leading to social unrest and instability. However, corrupt leaders often resist wealth redistribution because they benefit from maintaining economic inequality. A non-corrupt government is necessary to ensure fair wealth distribution. -/- Ensuring MMT Aligns with the Universal Law of Balance -/- The Philippines must apply MMT carefully to prevent economic imbalance. Simply printing money without strategic allocation will lead to inflation and instability. -/- Strict anti-corruption policies must be enforced to ensure MMT is used only for productive investments. -/- Public funds should be managed transparently, with regular audits and independent oversight. -/- Government leaders must be held accountable for economic decisions, ensuring they act in the best interest of all Filipinos. -/- A corrupt and incompetent government will lead to economic collapse under MMT, while a good, disciplined, and visionary government can use it to create lasting prosperity and stability. -/- Conclusion -/- Modern Monetary Theory, when properly applied, aligns with the universal law of balance in nature by ensuring that economic systems function without defects. The Philippines can use MMT to: -/- Increase GDP by investing in infrastructure, renewable energy, and industrialization. -/- Ensure GDP per capita growth by regulating population and creating sustainable jobs. -/- Reduce income inequality through education, healthcare, and wealth redistribution. -/- Maintain economic balance by applying feedback mechanisms such as taxation, productivity growth, and responsible government spending. -/- However, MMT requires a government that is competent, transparent, and corruption-free. Without ethical leadership, MMT will be abused and lead to inflation, economic collapse, and inequality. The law of balance demands that all systems—including governance—function properly to achieve economic stability. -/- By ensuring good governance, economic discipline, and strategic spending, the Philippines can use MMT to build a just, prosperous, and balanced society. -/- . (shrink)

The Holistic Governance Model (HGM): A Blueprint for the Future -/- Introduction -/- Governments today face increasing challenges, from economic instability and climate change to corruption and social inequality. No single government system has fully solved these issues, but by integrating the best aspects of existing models, we can create an optimal governance system. -/- The Holistic Governance Model (HGM) is a hybrid system that combines elements from Social Democracy, Technocracy, Semi-Direct Democracy, China’s Whole-Process People’s Democracy, and the Modified Westminster (...) System. It leverages AI-driven policy-making, technocratic expertise, direct citizen participation, and long-term national planning to create a balanced, efficient, and just government system. -/- 1. Core Foundations of the Holistic Governance Model -/- The HGM is built on six fundamental pillars, ensuring that governance is efficient, democratic, and sustainable. -/- 1.1. Economic System: A Hybrid of Capitalism and State Planning -/- Inspired by: Singapore (Technocracy), China (State-Controlled Development), Nordic Model (Social Welfare), and Switzerland (Financial Stability) ✅ Key Industries Under State Control: The government regulates healthcare, energy, and transportation while allowing free-market innovation. ✅ Smart Capitalism: Entrepreneurs and businesses thrive, but AI-driven economic planning ensures fair wealth distribution. ✅ Universal Basic Assets (UBA): Instead of universal basic income (UBI), citizens receive free housing, education, and healthcare, ensuring financial security. ✅ AI-Assisted Economy: AI predicts recessions, optimizes budgets, and prevents financial crises. -/- 1.2. Political System: A Dynamic Semi-Direct Democracy -/- Inspired by: Switzerland (Direct Democracy), Westminster System (Parliament), and Singapore (Meritocratic Leadership) ✅ Two-Tier Voting System: -/- General Elections: Citizens vote for representatives every 4-5 years. -/- National Referendums: Citizens directly vote on major policies twice a year. ✅ Technocratic Advisory Board (TAB): A non-political panel of scientists, economists, and AI experts advises the government. ✅ Decentralized Local Governance: Cities and regions have autonomy while aligning with national laws. -/- 1.3. Education & Human Development: AI-Powered Lifelong Learning -/- Inspired by: Nordic Model (Free Education), Singapore (STEM Focus), and China (AI Integration) ✅ Free Public Education for Life: Every citizen has access to continuous learning, including college and skill retraining. ✅ AI-Based Personalized Learning: Students use AI tutors that adapt to their learning pace. ✅ Ethics & Critical Thinking Curriculum: Courses in philosophy, logic, and decision-making prevent misinformation and ignorance. -/- 1.4. Healthcare & Social Welfare: AI-Driven Preventive Medicine -/- Inspired by: Nordic Model (Universal Healthcare), Singapore (Tech-Driven Healthcare), and China (Mass Coverage) ✅ Government-Funded Universal Healthcare: Citizens receive free basic healthcare, with private options available. ✅ AI & Robotics in Medicine: AI diagnoses diseases early, reducing medical costs. ✅ Preventive Healthcare Policy: Citizens receive incentives for maintaining good health (fitness programs, nutrition plans). -/- 1.5. Environmental & Energy Policies: The Green Industrial Revolution -/- Inspired by: China (Renewable Energy Expansion), Nordic Model (Sustainability Laws), and Singapore (Urban Planning) ✅ Mandatory Green Technology Adoption: Businesses must comply with strict eco-friendly policies. ✅ Carbon Credit Economy: Citizens and companies earn rewards for reducing carbon footprints. ✅ 100% Renewable Energy by 2050: The government funds solar, wind, and AI-optimized energy grids. -/- 1.6. Law & Order: AI-Governed Justice & Anti-Corruption Measures -/- Inspired by: Switzerland (Independent Judiciary), Singapore (Strict Law Enforcement), and China (AI in Governance) ✅ AI-Assisted Judiciary: AI helps judges analyze case laws for fair, unbiased rulings. ✅ Zero-Corruption Policy: Public officials caught in corruption face lifetime bans from government service. ✅ Balanced Civil Rights & Security: -/- Freedom of Speech: Citizens can express opinions, but disinformation is regulated. -/- AI Surveillance for Security: AI prevents crime while protecting privacy. -/- 2. Government Structure of HGM -/- 2.1. Executive Branch: The President, Prime Minister, and Technocrats -/- President (Elected by Public Vote) → Oversees national policies and international relations. -/- Prime Minister (Elected by Parliament) → Manages daily governance. -/- Technocratic Economic Council → Expert-led economic planning. -/- AI-Assisted Policy Bureau → Uses AI for healthcare, infrastructure, and environmental policies. -/- 2.2. Legislative Branch: Semi-Direct Parliament -/- Lower House (Elected Officials) → Creates laws based on citizen participation. -/- Upper House (Experts & Regional Representatives) → Reviews laws for scientific and ethical validity. -/- Referendum System → Citizens directly vote on key national issues. -/- 2.3. Judicial Branch: AI-Assisted Supreme Court -/- Independent Court System → Ensures justice and constitutional balance. -/- AI Legal Analysis → AI helps judges analyze previous cases and evidence. -/- 3. Implementation Strategy: How to Apply HGM Worldwide -/- To implement HGM, a phased approach is needed: -/- Phase 1 (0-5 Years): Research & AI Integration -/- ✅ Establish an HGM Global Research Center to develop AI governance models. ✅ Pilot AI-assisted economic planning in select countries. -/- Phase 2 (5-10 Years): Education & Public Awareness -/- ✅ Introduce HGM-based education systems (critical thinking, AI governance). ✅ Encourage political reforms to adopt hybrid governance models. -/- Phase 3 (10-20 Years): Nationwide Policy Implementation -/- ✅ Countries gradually adopt the HGM framework, with AI monitoring national progress. ✅ Global partnerships for climate change action and digital economy growth. -/- Phase 4 (Beyond 20 Years): Global Standardization -/- ✅ Establish an HGM Alliance for international cooperation. ✅ Implement AI-driven global policies on poverty, sustainability, and digital rights. -/- 4. Why the HGM is the Future of Governance -/- The Holistic Governance Model (HGM) offers the most advanced, efficient, and democratic government system by combining AI governance, citizen participation, economic stability, and social equality. -/- Conclusion: A Government System for the 21st Century -/- The Holistic Governance Model (HGM) combines the best government systems into a single, optimized model. By implementing AI, technocracy, direct democracy, and long-term planning, HGM ensures: ✅ Efficient economic management ✅ Social equality without excessive taxation ✅ Democratic participation with AI-driven transparency ✅ Sustainable environmental policies ✅ Corruption-free governance -/- If adopted globally, HGM could transform human civilization into a more just, advanced, and sustainable society. -/- . (shrink)

In this issue of the Report, James L. Bernat proposes an innovative and sophisticated distinction to justify the introduction of permanent cessation as a valid substitute standard for irreversible cessation in death determination. He differentiates two approaches to conceptualizing and determining death: the biological concept and the prevailing medical practice standard. While irreversibility is required by the biological concept, the weaker criterion of permanence, he claims, has always sufficed in the accepted standard medical practice to declare death. Bernat (...) argues that the medical practice standard may be acceptable on the ground that proving circulatory or brain permanence is sufficient to assure complete accuracy for death diagnosis. -/- The topic requires public deliberation: processes to survey people's opinions and mechanisms to channel their opinions into policy-making. What is at stake is the nature of our society. Do we want an expertocracy, in which an enlightened few design policies for the greater good of the majority and exploit the lack of public knowledge to achieve compliance? (shrink)

The Unified Theory of Free Will: The Three Universal Laws, Systemic Imbalance, and Nature’s Self-Correction -/- By Angelito Malicse -/- Introduction -/- For centuries, the concept of free will has been debated, with perspectives ranging from determinism to compatibilism and libertarianism. However, these traditional views fail to acknowledge the natural laws that govern human decision-making. By synthesizing the Universal Law of Balance in Nature, the Universal Feedback Loop Mechanism, and the Error-Free System, we establish a unified theory of free will—a (...) structured approach to human choices within the constraints of natural order. -/- Additionally, it is crucial to recognize the tolerance limits of hierarchical systems—both natural and man-made. When human decisions exceed these limits and imbalances persist, nature will automatically step in to restore equilibrium. This natural correction often manifests in disruptive ways, such as natural disasters, economic collapses, or social upheavals. Understanding these dynamics is essential to ensuring stability across all systems. -/- Furthermore, human emotions, which have evolved as essential survival mechanisms, play a dual role in maintaining or disrupting balance. Emotions influence decision-making, motivation, and social interactions. When properly regulated, they help individuals and societies adapt to challenges and maintain systemic harmony. However, when emotions exceed their tolerance limits—such as excessive fear leading to panic or unchecked anger causing conflict—they contribute to systemic imbalance and dysfunction. -/- The Three Universal Laws and Their Role in Decision-Making -/- 1. Universal Law of Balance in Nature -/- Every system—biological, social, and technological—operates within specific tolerance limits. Decisions that align with natural balance maintain stability, while those that exceed these limits lead to disruption. If humans fail to correct imbalances, nature will forcefully restore equilibrium, often through unpredictable and catastrophic means. -/- Examples of Balance, Systemic Imbalance, and Natural Correction: -/- Personal Health: A balanced diet sustains physical well-being, while excessive consumption leads to obesity and related diseases. If ignored, the body self-corrects through metabolic disorders and immune system responses. -/- Economic Stability: A balanced economy fosters growth, while financial mismanagement leads to economic crashes. Recessions and inflation serve as corrective mechanisms for financial excesses. -/- Environmental Sustainability: Responsible resource management ensures long-term survival, whereas overexploitation leads to climate change and natural disasters such as droughts and hurricanes, which force societies to adapt. -/- Ecosystem Regulation: Overfishing disrupts marine populations, but nature counters with species migration and ecological shifts that eventually restore stability. -/- Energy Consumption: Overuse of fossil fuels accelerates climate change, prompting extreme weather events and necessitating the shift to renewable energy sources. -/- 2. Universal Feedback Loop Mechanism -/- Decision-making must incorporate continuous feedback to ensure adaptation and refinement. Ignoring or distorting feedback results in inefficiencies and systemic collapse. -/- Examples of Feedback, Systemic Imbalance, and Nature’s Response: -/- Business Adaptation: Companies that respond to consumer feedback thrive, while those that ignore it collapse due to declining market relevance. -/- Political Governance: Leaders who suppress public concerns foster unrest, often leading to revolutions or government overhauls. -/- Technological Development: AI systems trained on biased or incomplete data develop flawed decision-making patterns, necessitating retraining and regulation. -/- 3. Error-Free System -/- Every decision has consequences, and ensuring 100 percent correct information is essential to maintaining systemic balance. Errors in data, assumptions, or implementation can trigger unintended disruptions. -/- Examples of Cause and Effect, Misinformation, and Systemic Collapse: -/- Academic Success: Proper study methods enhance learning, while reliance on ineffective strategies results in poor educational outcomes. -/- Industrialization and Environmental Impact: Sustainable practices protect ecosystems, while reliance on false environmental data accelerates degradation. -/- Global Resource Consumption: Inaccurate assessments of resource availability lead to economic and geopolitical instability. -/- The Evolution and Purpose of the Duality of Human Emotions -/- Human emotions have evolved as critical mechanisms for survival, adaptation, and social cohesion. They function as regulatory signals that guide decision-making, helping individuals and societies maintain equilibrium. However, emotions also possess a dual nature, where their misalignment or overexpression can lead to instability and dysfunction. -/- Positive Role of Emotions in Systemic Balance: -/- Empathy and Cooperation: Emotions such as compassion and trust foster social cohesion, strengthening communities and enhancing cooperation. -/- Fear and Caution: A moderate level of fear helps individuals assess risks and avoid dangerous situations, ensuring personal and collective safety. -/- Motivation and Ambition: Positive emotions such as enthusiasm and joy drive personal growth, innovation, and societal progress. -/- Negative Role of Emotions in Systemic Imbalance: -/- Excessive Fear and Panic: When fear surpasses a system’s tolerance limit, it leads to irrational decision-making, paranoia, and social instability. -/- Unchecked Anger and Conflict: Intense anger without regulation contributes to violence, political unrest, and societal fragmentation. -/- Despair and Apathy: Chronic negative emotions, such as depression and hopelessness, reduce individual productivity and can weaken societal resilience. -/- Examples of Emotional Duality in Decision-Making: -/- Public Health Responses: Balanced fear leads to precautionary health measures, while excessive panic results in chaos (e.g., misinformation-fueled reactions during pandemics). -/- Leadership and Governance: A compassionate leader fosters unity, while an authoritarian leader driven by anger and paranoia destabilizes societies. -/- Market Behavior: Optimistic investors drive economic growth, while fear-driven panic selling causes financial crashes. -/- Effects of Systemic Imbalances and Nature’s Automatic Correction -/- When human decisions disrupt equilibrium and corrective actions are not taken, nature enforces balance through forceful interventions. -/- Examples of Human-Induced Imbalances and Nature’s Response: -/- Healthcare Systems: Overuse of antibiotics results in drug-resistant bacteria, increasing disease severity and forcing new medical advancements. -/- Economic Systems: Financial bubbles burst, leading to recessions that correct speculative excesses. -/- Political Systems: Corrupt governance leads to revolutions, shifts in power, and societal restructuring. -/- Environmental Systems: Deforestation causes soil erosion and desertification, forcing human migrations and altering agriculture. -/- Overpopulation: Excessive growth strains resources, leading to food shortages, pandemics, and natural events that regulate population levels. -/- Urban Expansion: Overcrowding leads to declining infrastructure, pollution, and social conflicts, often prompting mass relocations and policy reforms. -/- Conclusion -/- Free will is not an arbitrary concept but a structured system governed by natural laws. By understanding the Universal Law of Balance in Nature, the Universal Feedback Loop Mechanism, and the Error-Free System, we can align human decisions with nature’s equilibrium. -/- Additionally, recognizing the evolution and duality of human emotions is essential for maintaining stability in personal and societal decision-making. If humanity fails to correct imbalances, nature will automatically restore equilibrium, often in ways that are catastrophic and beyond human control. -/- By integrating these principles into education, governance, and AI development, we pave the way for a rational, ethical, and self-correcting society. -/- . (shrink)

Genius Is Not About Popularity -/- Throughout history, the concept of genius has often been misunderstood. Many equate genius with fame, believing that the most recognized figures in science, art, and philosophy are necessarily the greatest minds. However, true genius is not about popularity; it is about depth of insight, originality of thought, and contributions to human progress, regardless of public recognition. Some of the most brilliant minds were overlooked in their time, yet their ideas shaped the future. This essay (...) explores why genius is independent of popularity and how history has proven that true intellectual greatness often transcends societal recognition. -/- The Nature of Genius -/- Genius is characterized by extraordinary intellectual ability, creativity, and the capacity to think beyond conventional wisdom. A true genius is not necessarily someone who seeks attention or public validation but someone who pursues knowledge and innovation for its own sake. Many geniuses are ahead of their time, which can result in their ideas being ignored or misunderstood. Unlike celebrities or influential public figures, a genius does not necessarily attract mass appeal because their work often requires a level of understanding that only a few can appreciate during their lifetime. -/- Unrecognized Geniuses in History -/- History is filled with examples of individuals whose genius was not recognized until long after their death. One of the most famous cases is Nikola Tesla, a brilliant inventor and engineer whose contributions to electrical engineering were largely overshadowed by more business-savvy figures like Thomas Edison. Tesla’s work on alternating current (AC) power revolutionized the world, yet he died in relative obscurity. -/- Another example is Gregor Mendel, the father of modern genetics. Mendel’s groundbreaking experiments with pea plants laid the foundation for genetic inheritance, yet his work was largely ignored during his lifetime. It was only decades later that scientists realized the significance of his discoveries, which are now fundamental to biology. -/- Similarly, Vincent van Gogh is celebrated today as one of the greatest painters in history, yet he sold only a few paintings during his lifetime. His artistic vision was not widely appreciated, and he struggled with poverty and mental illness. His posthumous fame is a testament to how genius is often ahead of its time and only recognized when society catches up with its vision. -/- The philosopher Søren Kierkegaard, who laid the foundation for existentialist thought, was largely dismissed during his lifetime. Today, his writings influence fields as diverse as philosophy, psychology, and theology. Similarly, Ada Lovelace, who worked on Charles Babbage’s early mechanical computer, was virtually unknown during her time but is now recognized as one of the first computer programmers. -/- Alan Turing, whose work in cryptography helped end World War II, was largely unrecognized in his lifetime due to prevailing social prejudices. His contributions to computer science and artificial intelligence were only widely acknowledged decades after his tragic death. Likewise, the works of Emily Dickinson, now considered some of the greatest poetry in American literature, remained unpublished until after her passing. -/- Another overlooked genius was Hypatia of Alexandria, a pioneering mathematician, astronomer, and philosopher in ancient Greece. Despite her immense contrib”tions to science and philosophy, she was largely erased from history due to political and religious turmoil. Similarly, Joseph Priestley, the scientist who discovered oxygen, did not receive immediate recognition because his findings conflicted with mainstream scientific beliefs at the time. -/- Another modern example is Rosalind Franklin, whose work in X-ray crystallography was crucial to the discovery of DNA’s double helix structure. However, her contributions were overshadowed by Watson and Crick, who received most of the credit for the discovery. Additionally, Ignaz Semmelweis, a 19th-century physician who introduced handwashing in medical practice to prevent infections, was dismissed and ridiculed during his time, only for his ideas to become foundational in modern medicine. -/- Other overlooked geniuses include Ludwig Boltzmann, who developed statistical mechanics, a cornerstone of modern physics. His work was dismissed by many during his lifetime, leading to his tragic death. Similarly, Emmy Noether, one of the greatest mathematicians in history, made groundbreaking contributions to abstract algebra and theoretical physics but was largely unrecognized due to gender biases. -/- Johan Sebastian Bach, now considered one of the greatest composers, was not widely appreciated during his lifetime and was overshadowed by more fashionable composers of his era. Likewise, Henri Poincaré, whose work in mathematics and theoretical physics laid the groundwork for chaos theory and relativity, was often overlooked in favor of his contemporaries. -/- Popularity vs. Impact -/- Popularity is often dictated by trends, media influence, and societal values, whereas genius is about intellectual contribution and long-term impact. Many popular figures may gain widespread recognition due to charisma, marketing, or entertainment value, but that does not necessarily mean they have made groundbreaking contributions to human knowledge. In contrast, some of the most transformative ideas in science, philosophy, and art have come from individuals who were not widely known in their era. -/- Moreover, some geniuses actively avoid the spotlight, preferring to focus on their work rather than public recognition. Albert Einstein, despite becoming famous later in life, initially worked in obscurity as a patent clerk before his theories revolutionized physics. Similarly, mathematician Srinivasa Ramanujan made astonishing contributions to number theory without formal education or widespread recognition during his lifetime. -/- The Importance of Recognizing True Genius -/- While popularity can bring attention to ideas, it is important to differentiate between recognition and true intellectual brilliance. Society should strive to support and acknowledge innovative thinkers even if their ideas are not immediately understood or appreciated. Educational institutions, scientific communities, and cultural organizations have a responsibility to foster environments where unconventional ideas can thrive, ensuring that genius is recognized based on merit rather than mass appeal. -/- Conclusion -/- Genius is not about popularity; it is about profound intellectual contributions that shape the world. Many great minds were overlooked in their time, only to be celebrated long after their deaths. History shows that true genius often works in obscurity, pushing the boundaries of knowledge regardless of societal recognition. Instead of equating fame with intelligence, we should value deep thinking, innovation, and originality, ensuring that future generations recognize and support those who truly advance human understanding. -/- . (shrink)

Precision medicine and molecular systems medicine (MSM) are highly utilized and successful approaches to improve understanding, diagnosis, and treatment of many diseases from bench-to-bedside. Especially in the COVID-19 pandemic, molecular techniques and biotechnological innovation have proven to be of utmost importance for rapid developments in disease diagnostics and treatment, including DNA and RNA sequencing technology, treatment with drugs and natural products and vaccine development. The COVID-19 crisis, however, has also demonstrated the need for systemic thinking and transdisciplinarity and the (...) limits of MSM: the neglect of the bio-psycho-social systemic nature of humans and their context as the object of individual therapeutic and population-oriented interventions. COVID-19 illustrates how a medical problem requires a transdisciplinary approach in epidemiology, pathology, internal medicine, public health, environmental medicine, and socio-economic modeling. Regarding the need for conceptual integration of these different kinds of knowledge we suggest the application of general system theory (GST). This approach endorses an organism-centered view on health and disease, which according to Ludwig von Bertalanffy who was the founder of GST, we call Organismal Systems Medicine (OSM). We argue that systems science offers wider applications in the field of pathology and can contribute to an integrative systems medicine by (i) integration of evidence across functional and structural differentially scaled subsystems, (ii) conceptualization of complex multilevel systems, and (iii) suggesting mechanisms and non-linear relationships underlying the observed phenomena. We underline these points with a proposal on multi-level systems pathology including neurophysiology, endocrinology, immune system, genetics, and general metabolism. An integration of these areas is necessary to understand excess mortality rates and polypharmacological treatments. In the pandemic era this multi-level systems pathology is most important to assess potential vaccines, their effectiveness, short-, and long-time adverse effects. We further argue that these conceptual frameworks are not only valid in the COVID-19 era but also important to be integrated in a medicinal curriculum. (shrink)

The World’s Leading Research and Development Institutions and Companies -/- Introduction -/- Research and Development (R&D) is the backbone of global innovation, driving technological progress, economic growth, and scientific discoveries. Across the world, top institutions and corporations invest billions of dollars into R&D to push the boundaries of human knowledge and create groundbreaking technologies. This essay explores the most influential research institutions and companies shaping the future through their contributions in science, engineering, medicine, and technology. -/- The Role of (...) Research Institutions in Global Innovation -/- Research institutions play a crucial role in advancing fundamental and applied sciences. Many of these institutions are publicly funded universities and government research agencies that focus on a wide range of disciplines, from medicine and engineering to artificial intelligence and space exploration. -/- 1. Leading Research Institutions -/- Some of the most prestigious research institutions include: -/- National Institutes of Health (NIH) – USA: The primary agency of the U.S. government responsible for biomedical and public health research. -/- National Aeronautics and Space Administration (NASA) – USA: A global leader in aerospace and space exploration, NASA continues to innovate in space technology and planetary science. -/- Centre National de la Recherche Scientifique (CNRS) – France: The largest governmental research organization in France, covering all scientific disciplines. -/- Max Planck Society – Germany: A network of research institutes in Germany, known for excellence in science and technology. -/- Chinese Academy of Sciences (CAS) – China: China’s premier research institution focuses on science and technology innovation across various fields. -/- Harvard University – USA: Leads in biomedical research, social sciences, and humanities. -/- Massachusetts Institute of Technology (MIT) – USA: At the forefront of engineering, robotics, artificial intelligence, and quantum computing research. -/- Stanford University – USA: Known for its deep ties to Silicon Valley, Stanford plays a key role in tech innovation. -/- University of Oxford & University of Cambridge – UK: Both institutions are among the oldest and most respected in the world, conducting high-impact research in medicine, engineering, and the humanities. -/- Swiss Federal Institute of Technology Zurich (ETH Zurich) – Switzerland: Excels in engineering and natural sciences research. -/- University of Tokyo – Japan: Japan’s leading university, known for its research in science and technology. -/- California Institute of Technology (Caltech) – USA: A leader in space science and physics. -/- Imperial College London – UK: Specializes in engineering, medical, and business research. -/- University of Toronto – Canada: A top institution in AI, robotics, and engineering. -/- 2. Engineering and Technology Research Leaders -/- Engineering research institutions contribute to infrastructure, automation, and digital transformation. Some of the most prominent ones include: -/- University of California, Berkeley – USA: Known for its research in engineering, computer science, and environmental science. -/- University of Pennsylvania – USA: Invests in innovative engineering projects. -/- University of Michigan – USA: Known for technological advancements in multiple fields. -/- Swiss Federal Institute of Technology Lausanne (EPFL) – Switzerland: Excels in engineering and digital research. -/- Tsinghua University – China: A leader in AI, renewable energy, and industrial automation research. -/- The Role of Private Companies in Research and Development -/- Private corporations play a major role in R&D, investing heavily in emerging technologies, pharmaceuticals, consumer electronics, and industrial innovations. Many of the world’s biggest companies spend billions to maintain leadership in their respective fields. -/- 1. Leading Technology Companies in R&D -/- Amazon ($73.2B in R&D spending, 2022): Focuses on cloud computing, AI, logistics, and automation. -/- Alphabet (Google) ($39.5B in R&D, 2022): Invests in AI, quantum computing, and search algorithms. -/- Meta (Facebook) ($35.3B in R&D, 2022): Focuses on AI, VR, and the Metaverse. -/- Apple ($27.7B in R&D, 2022): Leads in consumer electronics and semiconductor technology. -/- Microsoft ($26.6B in R&D, 2022): Invests in AI, cloud computing, and software innovation. -/- 2. Engineering and Industrial Companies in R&D -/- Volkswagen ($19.88B in R&D, 2022): A leader in automotive engineering and electric vehicles. -/- Samsung ($19.29B in R&D, 2022): Develops advanced semiconductors and electronics. -/- Intel ($17.53B in R&D, 2022): Focuses on microprocessors and AI hardware. -/- Huawei ($24B in R&D, 2022): Leads in telecommunications and 5G development. -/- Siemens – Germany: A global leader in industrial automation, medical technology, and smart infrastructure. -/- Nokia – Finland: Focuses on telecommunications infrastructure and technology development. -/- Sony – Japan: Invests in consumer electronics, gaming, and entertainment technologies. -/- Boeing – USA: Develops aerospace technology, defense systems, and commercial aircraft innovations. -/- General Electric (GE) – USA: Focuses on energy, aviation, and industrial automation R&D. -/- 3. Pharmaceutical and Biotech Research Leaders -/- Roche ($14.72B in R&D, 2022): A leading pharmaceutical company specializing in diagnostics and biotech innovations. -/- Pfizer: Known for vaccine development, including the COVID-19 vaccine. -/- Moderna: A pioneer in mRNA technology for medical treatments. -/- Johnson & Johnson: Invests heavily in medical devices and pharmaceuticals. -/- Bristol-Myers Squibb – USA: Focuses on biopharmaceutical research, including immunology and oncology. -/- AstraZeneca – UK/Sweden: Invests in pharmaceutical research, particularly in oncology and cardiovascular diseases. -/- The Impact of R&D on Society and the Future -/- The advancements driven by R&D have a profound impact on global society. Some of the most significant areas of innovation include: -/- Healthcare: Research in biotechnology, gene therapy, and medical AI is revolutionizing healthcare, leading to personalized medicine and new treatments for previously incurable diseases. -/- Artificial Intelligence: AI research in institutions and companies is driving automation, machine learning, and deep learning applications. -/- Sustainable Energy: Engineering research is focusing on renewable energy, electric vehicles, and smart grid technologies to combat climate change. -/- Space Exploration: Organizations like NASA, SpaceX, and ESA are expanding human exploration beyond Earth. -/- Telecommunications: Companies like Huawei, Nokia, and Qualcomm are leading the development of 5G and future wireless communication technologies. -/- Automotive Industry: Electric vehicles, hydrogen fuel cells, and autonomous driving are key research areas for companies like Tesla, Volkswagen, and Toyota. -/- Conclusion -/- The world’s leading R&D institutions and companies are shaping the future through their groundbreaking work in science, engineering, medicine, and technology. Universities and research centers provide the foundation for discovery, while corporations drive commercial applications of these innovations. As investments in R&D continue to grow, humanity will witness even greater advancements in fields such as artificial intelligence, biotechnology, and space exploration, ultimately improving lives and pushing the boundaries of what is possible. -/- . (shrink)

This paper explores the relation between victims’ stories and normativity. As a contribution to understanding how the stories of those who have been abused or oppressed can advance moral understanding, catalyze moral innovation, and guide social change, this paper focuses on narrative as a variegated form of representation and asks whether personal narratives of victimization play any distinctive role in human rights discourse. In view of the fact that a number of prominent students of narrative build normativity into their (...) accounts, it might seem obvious that there is a connection between victims’ stories and moral insight. However, the category of victims’ stories spans an enormous variety of texts – private diaries, memoirs written for publication, interviews with journalists or social scientists, depositions prepared by human rights workers, stories shared with like-minded activists or with support groups, stories told to medical professionals, and testimony in courts, truth commissions and asylum hearings, to mention just some of the possibilities. The different contexts of elicitation and the different rules governing expression in these sites should make us wary of ready generalizations about the nature of victims’ narratives. Moreover, I doubt that existing explications of the way in which norms figure in narratives yield satisfactory theories of the contribution victims’ stories can make to discovering and defending just policies and practices. I consider two of the most prominent accounts of the relation between narrative and normativity. For different reasons, the account Anthony Amsterdam and Jerome Bruner present in their work on narrative and law and the account Hayden White presents in his work on narrative and history fail to appreciate the capacity of victims’ stories of abuse to advance understanding of and increase respect for human rights. In defense of the value of victims’ stories, I propose an account of the relation between normativity and a salient type of victim’s narrative that seems especially resistant to integration into human rights discourse. -/- . (shrink)

This paper analyzes the underlying tendencies and attitudes toward reproductive medicine borrowing the Nietzschean concepts of nihilism: “death of God” with secularization; “will to power” with reproductive liberty and technological power; and the race of “supermen” with transhumanism. Medical science has advanced in leaps and bounds. In some way, technical innovations have given us unprecedented power to manipulate the way we reproduce. The indiscriminant use of medical technology is backed by a warped notion of human freedom. With secularization (...) in the West, freedom has taken on greater significance in society, but with a heavy emphasis on individual choices and rights. As technology joins forces with sexual liberty, it is not difficult to understand why the public accepts the latest novelty from the reproductive industry. As a result, many find Catholic teaching behind the times and incomprehensible, if not downright anti-scientific. In fact, this coupling of reproductive liberty (will) with reproductive technology (power) echoes the famous dictum “will to power” Nietzsche predicted would characterize post-modern societies. When liberty becomes absolute and technology unchecked, transhumanism is the logical outcome. As a response to these nihilistic tendencies, the paper will end with a critique drawing from theological insights. (shrink)

American writer William Carlos Williams (1883-1963 studied medicine at the University of Pennsylvania. Following the completion of his fellowships, he traveled to Germany to specialize in pediatrics. Upon returning to America, he established an independent medical practice. The experiences Williams acquired through his medical career provided a valuable source for his literary work, which focused on ordinary people and everyday situations. Williams endeavored to create a form of literature that accurately represented the American experience and he innovatively utilized (...) vernacular language. His literary output encompassed poetry, short stories, novels, essays, and plays, though he is primarily recognized as a poet. Among his significant works are Kora in Hell (1920), Spring and All (1923), Pictures from Brueghel and Other Poems (1962), the five-volume Paterson (1963, 1992), and Imaginations (1970). 'The Use of Force,' presented in translation here, originally appeared in the short story collection Life along the Passaic River. -/- [In Dutch: De Amerikaanse schrijver William Carlos Williams (1883-1963) studeerde geneeskunde aan de Universiteit van Pennsylvania. Na zijn coschappen ging hij naar Duitsland om zich in de kindergeneeskunde te specialiseren. Eenmaal terug in Amerika vestigde hij zich als zelfstandig arts. De ervaringen die Williams in zijn artsenpraktijk opdeed, vormden een dankbare bron voor zijn literaire werk waarin gewone mensen en alledaagse situaties centraal staan. Williams streefde naar een vorm van literatuur die recht deed aan de Amerikaanse ervaring en maakte op inventieve wijze gebruik van de taal van de straat. Hij schreef gedichten, verhalen, romans, essays en toneelstukken, maar staat voornamelijk bekend als dichter. Tot zijn belangrijkste werken horen Kora in Hell (1920), Spring and All (1923), Pictures from Brueghel and Other Poems (1962), het vijfdelige Paterson (1963, 1992) en Imaginations (1970). 'Het gebruik van geweld' ('The Use of Force'), dat hier is afgedrukt, komt oorspronkelijk uil de verhalenbundel Life along the Passaic River.]. (shrink)

The contribution aims to analyze the pathology of leprosy (al-ǧuḏām) and smallpox (al-ǧudarī) in the Arabic medical encyclopedia Kitāb al-Malakī, composed by the physician ʿAlī ibn al-ʿAbbas al-Maǧūsī, and in its two Latin translations, the Pantegni by Constantine the African and the Liber Regalis by Stephen of Antioch. The study of the Arabic text shows that the etiology of these diseases involves an interplay of different factors, including contagion, and explains to what extent the Kitāb al-Malakī presents original doctrines. (...) Secondly, by taking into account similarities and shifts in comparison with the Arabic original, the contribution shows how the two Latin translators faced the challenge of creating a new lexicon as a vehicle for the innovative translated ideas. (shrink)

Breast cancer is one of the leading causes of death among women worldwide. Early detection plays a crucial role in improving survival rates, and machine learning (ML) provides powerful tools for identifying cancerous tumors in medical imaging and diagnostic data. This paper explores various machine learning techniques used for breast cancer detection, with a particular focus on the Wisconsin Breast Cancer Dataset (WBCD). We evaluate several classification models, including Logistic Regression (LR), Support Vector Machine (SVM), k-Nearest Neighbors (k-NN), and (...) Random Forest (RF), for their ability to accurately classify benign and malignant tumors. The goal of this paper is to demonstrate the use of supervised learning techniques to enhance early breast cancer detection. (shrink)

Creativity and Intelligence: Emergent Properties of the Brain as a Balancing Mechanism for Overpopulation, Natural Disasters, and Diseases -/- The human brain is an extraordinary organ, capable of producing creativity and intelligence as emergent properties that allow humanity to address complex challenges. These traits are not merely tools for individual survival; they function as collective mechanisms to adapt to large-scale issues that threaten humanity’s balance with the environment. Overpopulation, natural disasters, and the prevalence of diseases and illnesses represent some of (...) the most significant pressures on human societies. Through the brain’s capacity for problem-solving and innovation, humanity has developed strategies to mitigate these challenges and maintain equilibrium within the universal law of balance. -/- The Brain as a Balancing Mechanism -/- At its essence, the brain operates as a dynamic system that processes external stimuli and generates adaptive responses. Creativity and intelligence arise from this system as tools to predict, analyze, and address challenges that disrupt balance. Overpopulation, natural disasters, and diseases disrupt human life on social, economic, and environmental levels, testing the brain’s ability to create solutions. -/- Creativity in Addressing Overpopulation -/- Overpopulation places immense strain on resources, ecosystems, and social structures, often leading to food shortages, environmental degradation, and urban overcrowding. The brain’s creative capacity has allowed humans to develop innovations to address these issues. Urban agriculture, such as vertical farming, is an example of how creativity has transformed food production in densely populated areas, reducing dependence on traditional farmland and conserving resources. Similarly, advancements in renewable energy technologies, such as solar and wind power, reduce the ecological footprint of growing populations, providing sustainable solutions to energy needs. -/- Creativity also plays a critical role in social policies and education. Family planning programs and reproductive health education have empowered individuals, particularly women, to make informed decisions, reducing population growth rates in many regions. These initiatives reflect the brain’s ability to create holistic solutions that align societal needs with the preservation of natural balance. -/- Intelligence in Managing Natural Disasters -/- Natural disasters, unpredictable and often catastrophic, require intelligent strategies to mitigate their impact. Intelligence enables humans to analyze data, predict disasters, and prepare for their consequences. Early warning systems for tsunamis, hurricanes, and earthquakes exemplify this, providing communities with critical time to evacuate and take protective measures. -/- Furthermore, intelligence drives the design of resilient infrastructure that can withstand disasters. For instance, earthquake-resistant buildings and flood mitigation systems demonstrate the brain’s capacity to transform scientific knowledge into practical solutions. These innovations save lives, reduce economic losses, and facilitate faster recovery after disasters, ensuring that human societies maintain their balance despite nature’s unpredictability. -/- Creativity and Intelligence in Combating Diseases and Illnesses -/- Diseases and illnesses have long been among humanity’s greatest challenges, especially in the context of overpopulation, which facilitates the rapid spread of infectious diseases. The brain’s emergent properties of creativity and intelligence have been critical in combating these threats through advancements in medicine, public health, and technology. -/- The development of vaccines, antibiotics, and antiviral drugs highlights humanity’s creative response to disease. For example, the eradication of smallpox and the near-elimination of polio are milestones achieved through creative and intelligent applications of medical science. During the COVID-19 pandemic, intelligence and creativity led to the rapid development of vaccines using mRNA technology, showcasing the brain’s ability to adapt to new challenges at an unprecedented pace. -/- Public health strategies, such as sanitation systems, clean water initiatives, and disease surveillance networks, also reflect the brain’s ability to create systemic solutions. These measures have significantly reduced the burden of communicable diseases, particularly in densely populated areas. Moreover, advancements in artificial intelligence and biotechnology continue to enhance humanity’s ability to detect, prevent, and treat illnesses. -/- The Interplay of Creativity, Intelligence, and Feedback Mechanisms -/- Creativity and intelligence act as feedback mechanisms that enable humans to respond to disruptions while maintaining balance within the universal law of nature. Overpopulation, natural disasters, and diseases disrupt this balance, prompting the brain to generate solutions that restore harmony. -/- For instance, urban planning that incorporates green spaces and sustainable infrastructure addresses the environmental strain caused by overpopulation. Similarly, the integration of traditional knowledge with modern technologies enhances disaster resilience. In the context of diseases, the collaboration of global institutions and local communities reflects the brain’s capacity to balance innovation with cultural and social considerations. -/- Challenges and Ethical Considerations -/- While creativity and intelligence empower humanity to address these challenges, they also carry significant ethical responsibilities. Technological advancements must align with principles of sustainability and equity. For example, while vaccines have saved millions of lives, unequal access to these innovations highlights the need for ethical distribution systems. Similarly, urban development projects must prioritize environmental conservation and community well-being to avoid exacerbating existing imbalances. -/- Additionally, the misuse of intelligence and creativity—such as the development of biological weapons or unsustainable industrial practices—can worsen the effects of overpopulation, natural disasters, and diseases. Ensuring that human ingenuity aligns with the principles of balance and harmony is essential to avoid unintended consequences. -/- Conclusion -/- Creativity and intelligence are emergent properties of the human brain that have enabled humanity to adapt to and mitigate the negative effects of overpopulation, natural disasters, and diseases. These traits function as balancing mechanisms, allowing humans to innovate and maintain harmony within the framework of natural laws. However, the application of these capabilities must be guided by ethical considerations and a commitment to sustainability. By aligning human creativity and intelligence with the universal law of balance, humanity can navigate its most pressing challenges and build a more resilient and equitable future. -/- . (shrink)

Recent evidence shows significant potential for therapies involving psychedelic substances such as psilocybin and MDMA to improve clinical outcomes for patients experiencing various mental disorders. However, research to date focuses almost exclusively on adults. I argue that adolescents should be included in research into psychedelic therapies. First, I demonstrate the pressing need for novel interventions to address the growing mental health burden of adolescents, and I draw on empirical evidence to show that research into psychedelic therapies presents an opportunity to (...) address this shortfall. Secondly, I argue that psychedelics pose low risk to young patients, particularly relative to existing psychiatric medications. I then address two major concerns specific to adolescent contexts. First, I address the risks of using psychedelic substances at earlier stages of physiological and cognitive development. I note that the lack of understanding of the risks underscores the need for including adolescents in research. I then address the added complexity of consent in the adolescent context. I highlight some additional concerns that should be addressed in an “enhanced” informed consent process for adolescents and defend the view that capable adolescents should be able to consent to psychedelic interventions. I ultimately hold that including adolescents in emerging psychedelic research has the potential to substantiate innovative treatments that could improve their clinical outcomes, long-term mental health and quality of life. (shrink)

This commentary examines the role of sustainability in the latest draft of the WHO pandemic accord, highlighting its notable absence from the official list of guiding principles despite being mentioned frequently throughout the text. It argues that sustainability should be explicitly acknowledged as a core principle and given a clear definition tailored to pandemic preparedness, and proposes defining sustainability as ensuring that immediate emergency responses don't compromise future pandemic preparedness and response capabilities. Including sustainability as a guiding principle would serve (...) two key purposes: validating the relevance of ethical principles in the accord's provisions and emphasizing the importance of long-term planning in pandemic preparedness. The commentary notes that while humans naturally discount future consequences, sustainable pandemic planning requires considering impacts beyond the next pandemic. It recommends coupling any reforms, such as intellectual property changes, with alternative innovation incentives to maintain a balanced approach to pandemic preparedness and response. (shrink)